7UMB

KSR2 (Kinase suppressor of Ras 2)
MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1)
Pseudokinase
Group: STE TKL
Uniprot: MP2K1_HUMAN KSR2_HUMAN
Organism: Homo sapiens
Domain boundary: 68 - 361 666 - 930
Resolution: 3.231

Chain id Group Gene UniprotID Protein Organism Activity Spatial Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
C STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens Inactive DFGin BLBplus out-out out-out ANP U9F Type1 Type3 41 - 381 0
B TKL KSR2 KSR2_HUMAN Kinase suppressor of Ras 2 Homo sapiens Inactive DFGin BLBplus out-none out-out ANP Type1 652 - 932 3
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
         -          -        638        648 
msyyhhhhhh dydipttenl yfqgaemnls llsarsfprk 
       658        668        678        688 
asqTSIFLQE WDIPFEQLEI GELIGKGRFG QVYHGRWhGE 
       698        708        718        728 
VAIRLIDIER DNEDQLKAFK REVMAYRQTR HENVVLFMGA 
       738        748        758        768 
CMSPPHLAII TSLCKGRTLY SVVRDAKIVL DVNKTRQIAQ 
       778        788        798        808 
EIVKGMGYLH AKGILHKDLK SKNVFYDNGK VVITDFGLFS 
       818        828        838        848 
ISGVLQagrR EDKLRIQNGW LCHLAPEIIR QLSPDTEEDK 
       858        868        878        888 
LPFSKHSDVF ALGTIWYELH AREWPFKTQP AEAIIWQMGT 
       898        908        918        928 
GMKPNLSQIG MGKEISDILL FCWAFEQEER PTFTKLMDML 
       938        948 
EKLPkrnrrl shpghfwksa el
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: None