7XLP

MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1)
Group: STE
Uniprot: MP2K1_HUMAN
Organism: Homo sapiens
Domain boundary: 68 - 361
Resolu: 2.1

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLBplus out-out out-out FZC Type1.5_Back 37 - 382 4
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain A
        45         55         65         75 
gLEELELDEQ QRKRLEAFLT QKQKVGELKD DDFEKISELG 
        85         95        105        115 
AGNGGVVFKV SHKPSGLVMA RKLIHLEIKP AIRNQIIREL 
       125        135        145        155 
QVLHECNSPY IVGFYGAFYS DGEISICMEH MDGGSLDQVL 
       165        175        185        195 
KKAGRIPEQI LGKVSIAVIK GLTYLREKHK IMHRDVKPSN 
       205        215        225        235 
ILVNSRGEIK LCDFGVSGQL IDSMAnsfvG TRSYMSPERL 
       245        255        265        275 
QGTHYSVQSD IWSMGLSLVE MAVGRYPIPP PDAKELELMF 
       285        295        305        315 
Gcqvegdaae tpprprtpgr plnkkgmdsr pPMAIFELLD 
       325        335        345        355 
YIVNEPPPKL PSGVFSLEFQ DFVNKCLIKN PAERADLKQL 
       365        375 
MVHAFIKRSD AEEVDFAGWL CSTIGLNq
Lower-case residues are disordered in structure.
Mutations: S298N,S299K,Y300K
Phosphorylation: None