7JV0

MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1)
KSR1 (Kinase suppressor of Ras 1)
Pseudokinase
Group: TKL STE
Uniprot: MP2K1_RABIT KSR1_HUMAN
Organism: Homo sapiens Oryctolagus cuniculus
Domain boundary: 68 - 361 613 - 879
Resolution: 3.63

Chain id Group Gene UniprotID Protein Organism Activity Spatial Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
C STE MAP2K1 MP2K1_RABIT Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus Inactive DFGin BLBplus out-out out-out ANP 4BM Type1 Type3 40 - 382 0
A TKL KSR1 KSR1_HUMAN Kinase suppressor of Ras 1 Homo sapiens Inactive DFGin BLBplus out-none out-out ANP Type1 601 - 881 5
Representative sequence - Chain A
- - 595 605
msyyhhhhhh dydipttenl yfqgapisrk asqtsVYLQE
615 625 635 645
WDIPFEQVEL GEPIGQGRWG RVHRGRWHGE VAIRLLEMDG
655 665 675 685
HNQDHLKLFK KEVMNYRQTR HENVVLFMGA CMNPPHLAII
695 705 715 725
TSFCKGRTLH SFVRDPKTSL DINKTRQIAQ EIIKGMGYLH
735 745 755 765
AKGIVHKDLK SKNVFYDNGK VVITDFGLFG ISGVVregrr
775 785 795 805
ENQLKLSHDW LCYLAPEIVR EMTPGKDEDQ LPFSKAADVY
815 825 835 845
AFGTVWYELQ ARDWPLKNQA AEASIWQIGS GEGMKRVLTS
855 865 875 885
VSLGKEVSEI LSACWAFDLQ ERPSFSLLMD MLEKLPklnr
895
rlshpghfwk saei
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: None