5YT3

MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1)
Group: STE
Uniprot: MP2K1_HUMAN
Organism: Homo sapiens
Domain boundary: 68 - 361
Resolu: 2.9

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGinter None out-out none-none ANP Type1 39 - 382 14
B Inactive DFGin None out-out out-out ANP Type1 40 - 382 0
C Inactive DFGin BLBplus out-none none-none ANP Type1 40 - 382 17
D Inactive DFGin None out-out out-out ANP Type1 39 - 382 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain D
        48         58         68         78 
ELELDEQQRK RLEAFLTQKQ KVGELKDDDF EKISELGAGN 
        88         98        108        118 
GGVVFKVSHK PSGLVMARKL IHLeiKPAIR NQIIRELQVL 
       128        138        148        158 
HECNSPYIVG FYGAFYSDGE ISICMEHMDG GSLDQVLKKA 
       168        178        188        198 
GRIPEQILGK VSIAVIKGLT YLREKHKIMH RDVKPSNILV 
       208        218        228        238 
NSRGEIKLCD FGVSGQLIDD MANDFVGTRS YMSPERLQGT 
       248        258        268        278 
HYSVQSDIWS MGLSLVEMAV GRYPIPPPDA KELELMFgcq 
       288        298        308        318 
vegdaaetpp rprapgrpla sygmdsrppm AIFELLDYIV 
       328        338        348        358 
NEPPPKLPSG VFSLEFQDFV NKCLIKNPAE RADLKQLMVH 
       368        378          - 
AFIKRSDAEE VDFAGWLCST IGLNhhhhhh
Lower-case residues are disordered in structure.
Mutations: S218D,S222D,T292A,S298A
Phosphorylation: None