7MFD

BRAF (Serine/threonine-protein kinase B-raf)
MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1)
Group: TKL STE
Uniprot: MP2K1_HUMAN BRAF_HUMAN
Organism: Homo sapiens
Domain boundary: 68 - 361 457 - 716
Resolution: 3.66

Chain id Group Gene UniprotID Protein Organism Activity Spatial Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
B STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens Inactive DFGin BLBplus out-out out-out CHU Type3 52 - 383 0
A TKL BRAF BRAF_HUMAN Serine/threonine-protein kinase B-raf Homo sapiens Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 156 - 738 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain A
        10         20         30         40 
maalsggggg gaepgqalfn gdmepeagag agaaassaad 
        50         60         70         80 
paipeevwni kqmikltqeh iealldkfgg ehnppsiyle 
        90        100        110        120 
ayeeytskld alqqreqqll eslgngtdfs vsssasmdtv 
       130        140        150        160 
tsssssslsv lpsslsvfqn ptdvarsnpk spqkpIVRVF 
       170        180        190        200 
LPNKQRTVVP ARCGVTVRDS LKKALMMRGL IPECCAVYRI 
       210        220        230        240 
QdgEKKPIGW DTDISWLTGE ELHVEVLenv plttHNFVRK 
       250        260        270        280 
TFFTLAFCDF CRKLLFQGFR CQTCGYKFHQ RCStevplmc 
       290        300        310        320 
vnydqldllf vskffehhpi pqeeaslaet altsgsspsa 
       330        340        350        360 
pasdsigpqi ltspspsksi pipqpfrpad edhrnqfgqR 
       370        380        390        400 
DRSSSAPNVH intiepvnid dlirdqgfrg dggsttglsa 
       410        420        430        440 
tppaslpgsl tnvkalqksp gpqrerksss ssedrnrmkt 
       450        460        470        480 
lgrrdssdDW EIPDGQITVG QRIGSGSFGT VYKGKWHGDV 
       490        500        510        520 
AVKMLNVTAP TPQQLQAFKN EVGVLRKTRH VNILLFMGYS 
       530        540        550        560 
TKPQLAIVTQ WCEGSSLYHH LHIIETKFEM IKLIDIARQT 
       570        580        590        600 
AQGMDYLHAK SIIHRDLKSN NIFLHEDLTV KIGDFGLATV 
       610        620        630        640 
KSRWSGSHQF EQLSGSILWM APEVIRMQDK NPYSFQSDVY 
       650        660        670        680 
AFGIVLYELM TGQLPYSNIN NRDQIIFMVG RGYLSPDLSK 
       690        700        710        720 
VRSNCPKAMK RLMAECLKKK RDERPLFPQI LASIELLARS 
       730        740        750        760 
LPKIHRSASE PSLNRAGFqt edfslyacas pktpiqaggy 

gafpvh
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: X365,X729