2Y4I

MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1)
KSR2 (Kinase suppressor of Ras 2)
Pseudokinase
Group: TKL STE
Uniprot: KSR2_HUMAN MP2K1_RABIT
Organism: Oryctolagus cuniculus Homo sapiens
Domain boundary: 68 - 361 666 - 930
Resolution: 3.46

Chain id Group Gene UniprotID Protein Organism Activity Spatial Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
C STE MAP2K1 MP2K1_RABIT Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus Inactive DFGin BLBplus out-out out-out ATP Type1 37 - 381 0
B TKL KSR2 KSR2_HUMAN Kinase suppressor of Ras 2 Homo sapiens Inactive DFGin BLBplus out-none out-out ATP Type1 653 - 931 10
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
       641        651        661        671 
gpemnlslls arsfprkasq tSIFLQEWDI PFEQLEIGEL 
       681        691        701        711 
IGKGRFGQVY HGRWHGEVAI RLIDIERDNE DQLKAFKREV 
       721        731        741        751 
MAYRQTRHEN VVLFMGACMS PPHLAIITSL CKGRTLYSVV 
       761        771        781        791 
RDAKIVLDVN KTRQIAQEIV KGMGYLHAKG ILHKDLKSKN 
       801        811        821        831 
VFYDngKVVI TDFGLFSisg vlqagrrEDK LRIQNGWLCH 
       841        851        861        871 
LAPEIIRQLS PDteEDKLPF SKHSDVFALG TIWYELHARE 
       881        891        901        911 
WPFKTQPAEA IIWQMGTGMK PNLSQIGMGK EISDILLFCW 
       921        931        941 
AFEQEERPTF TKLMDMLEKL pkrnrrlshp ghfwksael
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: None