3EQC

MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1)
Group: STE
Uniprot: MP2K1_HUMAN
Organism: Homo sapiens
Domain boundary: 68 - 361
Resolu: 1.8

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLBplus out-out out-out 3BM AGS Type3 Type1 39 - 382 3
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain A
        43         53         63         73 
gkkleELELD EQQRKRLEAF LTQKQKVGEL KDDDFEKISE 
        83         93        103        113 
LGAGNGGVVF KVSHKPSGLV MARKLIHLEI KPAIRNQIIR 
       123        133        143        153 
ELQVLHECNS PYIVGFYGAF YSDGEISICM EHMDGGSLDQ 
       163        173        183        193 
VLKKAGRIPE QILGKVSIAV IKGLTYLREK HKIMHRDVKP 
       203        213        223        233 
SNILVNSRGE IKLCDFGVSG QLIDSMAnsf VGTRSYMSPE 
       243        253        263        273 
RLQGTHYSVQ SDIWSMGLSL VEMAVGRYPI PPPDAKELEL 
       283        293        303        313 
MFGCqvegda aetpprprtp grplnkfgmd srpPMAIFEL 
       323        333        343        353 
LDYIVNEPPP KLPSGVFSLE FQDFVNKCLI KNPAERADLK 
       363        373        383        393 
QLMVHAFIKR SDAEEVDFAG WLCSTIGLNq pstpthaagv


Lower-case residues are disordered in structure.
Mutations: S298N,S299K,Y300F
Phosphorylation: None