CAMK_AURKA (Aurora kinase A)

Total number of chains: 235
Active chains: 7
Uniprot: AURKA_HUMAN
Kinase Domain Residues: 133 - 383
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 103 43.8% AF-O14965-K1A
DFGinter None 67 28.5% 5L8LA
DFGin None 19 8.1% 2J4ZB
DFGin ABAminus 18 7.7% 3E5AA
None None 18 7.7% 5OBRA
DFGout None 7 3.0% 6VPHA
DFGin BLAplus 1 0.4% 4J8MA
DFGin BLBminus 1 0.4% 8PR7D
DFGout BBAminus 1 0.4% 2C6EA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AURKA 1OL5A O14965 123 388 403.0 ADP:1388 ATPlike Active DFGin 5.5782 15.0961 BLAminus -139.2, -172.08 52.22, 80.16 -90.83, 24.66 282.61, 72.55 -49.87, -44.18 in-in in 9.4508 Saltbr-in 2.9117 HRD-in -63.28, -60.88 73.6, 1.59 in-in-in SNCiii in-in ActLoopNT-in 2.9276 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.42, 162.5 APE9-dihe-na 119.45, -153.19 APE8-dihe-in -110.77, 140.24 APE8-rot-in 313.06 APE67-dihe-in -62.23, -14.3 -43.16, -62.5 APE12-dist-in 8.1744 APE11-dist-in 10.9573 APE10-dist-in 5.2741 APE9-dist-in 3.683 None TPO287,TPO288 TPO287,TPO288 XRAY 2.5 0.194 0.252 A 282.0 266.0 0 26 26 0 [[133, 383]] 1.0 1ol5 CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 6VPGA O14965 7 389 403.0 ANP:60401 ATPlike Active DFGin 5.3184 15.0701 BLAminus -133.54, 176.05 56.91, 81.54 -90.61, 23.9 286.39, 75.22 -62.73, -9.76 in-in in 9.8844 Saltbr-in 2.9538 HRD-in -72.51, -51.0 67.55, 11.3 in-in-in SNCiii in-in ActLoopNT-in 3.0433 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.96, 159.16 APE9-dihe-na 122.67, -152.53 APE8-dihe-in -117.94, 146.39 APE8-rot-in 309.68 APE67-dihe-in -61.83, -12.97 -52.19, -62.88 APE12-dist-in 8.5172 APE11-dist-in 11.4274 APE10-dist-in 5.7242 APE9-dist-in 3.8329 None TPO287,TPO288 TPO287,TPO288 XRAY 2.64 0.204 0.245 A 292.0 267.0 0 26 26 0 [[133, 383]] 1.0 6vpg CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5LXMA O14965 126 392 403.0 ADP:60501 ATPlike Active DFGin 5.3906 14.9756 BLAminus -135.45, -179.78 54.7, 80.97 -90.8, 30.12 283.16, 71.51 -72.4, -3.16 in-in in 9.2473 Saltbr-in 2.7237 HRD-in -74.23, -48.55 66.99, 5.01 in-in-in SNCiii in-in ActLoopNT-in 3.1136 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.91, 137.37 APE9-dihe-na 128.62, -150.21 APE8-dihe-in -129.87, 142.81 APE8-rot-in 303.47 APE67-dihe-in -69.71, -10.62 -37.99, -61.07 APE12-dist-in 8.2574 APE11-dist-in 10.6918 APE10-dist-in 5.2126 APE9-dist-in 3.2978 C290A,C393A TPO288 TPO288 XRAY 2.08 0.202 0.243 A 283.0 267.0 0 26 26 0 [[133, 383]] 1.0 5lxm CAMK_AURKA_HUMAN CAMK 9.2e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5G1XA O14965 126 389 403.0 ADP:1390 ATPlike Active DFGin 5.3433 15.03 BLAminus -132.86, -170.57 52.68, 76.5 -90.96, 13.96 279.12, 78.43 -59.51, -20.51 in-in in 9.2783 Saltbr-in 2.828 HRD-in -82.61, -50.12 70.7, 5.33 in-in-in SNCiii in-in ActLoopNT-in 2.9632 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.42, -179.26 APE9-dihe-na 65.74, -155.89 APE8-dihe-in -128.23, 121.78 APE8-rot-in 304.75 APE67-dihe-in -61.27, -19.7 -46.07, -47.67 APE12-dist-in 8.2472 APE11-dist-in 10.7994 APE10-dist-in 5.5303 APE9-dist-in 3.699 C290A,C393A TPO288 TPO288 XRAY 1.72 0.177 0.195 A 285.0 264.0 0 26 26 0 [[133, 383]] 1.0 5g1x CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 7ZTLA O14965 126 389 403.0 ADP:501,BCN:506 ATPlike,Allosteric Active DFGin 5.6229 15.1084 BLAminus -131.55, 179.55 58.91, 75.38 -87.97, 22.52 281.42, 69.29 -65.3, -21.25 in-in in 9.2252 Saltbr-in 2.815 HRD-in -81.87, -52.88 75.2, 3.05 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.79, 177.44 APE9-dihe-na 70.08, -157.96 APE8-dihe-in -126.05, 125.84 APE8-rot-in 309.73 APE67-dihe-in -58.88, -23.16 -51.84, -48.56 APE12-dist-in 8.1263 APE11-dist-in 10.6011 APE10-dist-in 5.3541 APE9-dist-in 3.7652 C290A,K339C,C393A TPO288 TPO288 XRAY 1.9 0.165 0.193 A 309.0 264.0 0 26 26 0 [[133, 383]] 1.0 7ztl CAMK_AURKA_HUMAN CAMK 4.2e-78 268.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AF-O14965-K1A O14965 125 391 403.0 No_ligand No_ligand Active DFGin 5.5289 14.8803 BLAminus -132.48, -179.84 57.24, 70.17 -79.24, 16.4 282.35, 77.01 -58.05, -32.04 in-in in 9.2276 Saltbr-in 2.708 HRD-in -80.88, -51.09 67.96, 12.7 in-in-in SNCiii in-in ActLoopNT-in 2.9572 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.18, 173.11 APE9-dihe-na 86.42, -161.65 APE8-dihe-in -116.22, 122.78 APE8-rot-in 305.5 APE67-dihe-in -58.7, -20.28 -46.82, -49.92 APE12-dist-in 8.4312 APE11-dist-in 11.2268 APE10-dist-in 5.5558 APE9-dist-in 3.551 None None None AF2 -1.0 1.0 1.0 A 267.0 267.0 0 26 26 0 [[133, 383]] 1.0 AF-O14965-K1 CAMK_AURKA_HUMAN CAMK 6e-80 274.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AF-O14965-K3A O14965 125 391 403.0 No_ligand No_ligand Active DFGin 5.6976 15.2161 BLAminus -127.1, 175.03 53.67, 75.17 -77.09, 18.89 286.79, 79.82 -57.24, -36.78 in-in in 9.9525 Saltbr-in 2.8263 HRD-in -82.42, -50.55 68.17, 14.97 in-in-in SNCiii in-in ActLoopNT-in 2.9389 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.94, 160.76 APE9-dihe-na 99.46, -154.48 APE8-dihe-in -120.71, 133.3 APE8-rot-in 307.63 APE67-dihe-in -63.76, -17.86 -47.79, -50.9 APE12-dist-in 8.7606 APE11-dist-in 11.2833 APE10-dist-in 5.5717 APE9-dist-in 3.5882 None None None AF2 -1.0 1.0 1.0 A 267.0 267.0 0 26 26 0 [[133, 383]] 1.0 AF-O14965-K3 CAMK_AURKA_HUMAN CAMK 6e-80 274.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4C3PD O14965 125 390 403.0 ACP:1391 ATPlike Inactive DFGin 5.0797 15.0907 ABAminus -119.78, -23.96 -110.92, 146.31 -144.29, 22.56 288.75, 97.88 -63.46, -34.21 out-out out 11.1639 Saltbr-out 5.9729 HRD-out -75.78, -41.12 71.55, -101.13 out-in-out SNCoio in-out ActLoopNT-in 3.1113 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nooo APE10-dihe-na -140.51, -146.18 APE9-dihe-na 83.68, 6.59 APE8-dihe-out -140.3, 13.24 APE8-rot-out 207.12 APE67-dihe-in -44.87, -30.51 -70.19, -27.98 APE12-dist-none 999.0 APE11-dist-out 20.8704 APE10-dist-out 24.1292 APE9-dist-out 28.582 None None None XRAY 2.69 0.205 0.289 D 282.0 260.0 6 26 20 6 [[133, 383]] 1.0 4c3p CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 8GUWA O14965 506 388 403.0 ADP:60501 ATPlike Inactive DFGin 5.4961 16.0011 ABAminus -116.4, -50.49 -101.78, 116.28 -108.31, 28.43 281.67, 88.04 -72.88, -24.68 out-out out 11.7793 Saltbr-out 6.9626 HRD-out -52.32, 144.81 -137.03, 32.44 out-in-out SNCoio in-out ActLoopNT-in 2.989 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 154.24 APE8-dihe-in -135.99, 160.18 APE8-rot-out 182.57 APE67-dihe-in -45.22, -30.26 -102.15, -5.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 22.8351 C290A,C393A None None XRAY 2.7 0.216 0.258 A 304.0 259.0 7 26 19 7 [[133, 383]] 1.0 8guw CAMK_AURKA_HUMAN CAMK 1.2e-78 270.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 8GUWB O14965 507 390 403.0 ADP:60501 ATPlike Inactive DFGin 5.2903 15.6844 ABAminus -103.46, -56.86 -84.59, 164.71 -149.11, 43.73 280.55, 102.4 -37.77, -51.78 out-out out 11.2219 Saltbr-out 10.1241 HRD-out -88.2, 114.65 -57.32, -35.01 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 120.59 APE8-rot-out 188.97 APE67-dihe-out 79.95, -4.59 -68.08, -173.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C290A,C393A None None XRAY 2.7 0.216 0.258 B 304.0 250.0 13 26 13 13 [[133, 383]] 1.0 8guw CAMK_AURKA_HUMAN CAMK 1.2e-78 270.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 8GUWC O14965 506 388 403.0 ADP:60501 ATPlike Inactive DFGin 5.7941 16.123 ABAminus -112.39, -57.42 -66.39, 155.71 -143.31, 23.7 266.43, 102.44 -50.18, -24.58 out-out out 11.5307 Saltbr-out 6.1466 HRD-out -98.37, 113.81 -121.54, 28.92 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -46.16 APE8-rot-in 299.01 APE67-dihe-in -63.17, -8.64 -58.96, -54.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C290A,C393A None None XRAY 2.7 0.216 0.258 C 304.0 248.0 18 26 12 14 [[133, 383]] 1.0 8guw CAMK_AURKA_HUMAN CAMK 1.2e-78 270.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5DPVA O14965 127 389 403.0 5DN:401,SKE:402 Allosteric,Type1 Inactive DFGin 6.2227 16.2094 ABAminus -110.93, -43.26 -110.84, 101.02 -87.51, 23.53 278.79, 82.59 -59.61, -51.22 out-in out 10.5383 Saltbr-in 3.388 HRD-in -62.88, -51.13 56.61, 19.56 in-in-out SNCiio in-out ActLoopNT-in 3.1231 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 144.36 APE9-dihe-na -94.43, -124.73 APE8-dihe-in -73.05, 138.31 APE8-rot-in 266.66 APE67-dihe-in -36.64, -38.36 -81.1, -11.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.4807 APE9-dist-out 10.3541 T287A None None XRAY 2.285 0.225 0.28 A 273.0 257.0 6 26 20 6 [[133, 383]] 1.0 5dpv CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5DR6A O14965 127 390 403.0 5E1:401,SKE:402 Allosteric,Type1 Inactive DFGin 6.2554 16.2435 ABAminus -109.16, -45.28 -112.39, 100.25 -88.77, 25.04 278.19, 83.44 -61.53, -50.53 out-in out 10.5931 Saltbr-in 3.4325 HRD-in -66.11, -48.32 65.82, 8.05 in-in-out SNCiio in-out ActLoopNT-in 2.9691 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 145.11 APE9-dihe-na -94.91, -119.28 APE8-dihe-in -76.91, 137.76 APE8-rot-in 267.0 APE67-dihe-in -38.0, -37.59 -81.57, -10.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.3936 APE9-dist-out 10.6234 T287A None None XRAY 2.534 0.221 0.278 A 273.0 257.0 7 26 19 7 [[133, 383]] 1.0 5dr6 CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2WTWA O14965 128 389 403.0 ZZL:1390 Type1 Inactive DFGin 5.0295 15.5299 ABAminus -106.44, -45.36 -104.13, 150.11 -135.47, 26.63 287.92, 83.14 -51.9, -25.54 out-out out 11.468 Saltbr-out 6.0234 HRD-in -69.03, -60.65 76.28, -17.41 out-in-out SNCoio in-out ActLoopNT-in 2.8667 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 10.4 APE9-dihe-na -133.69, -108.65 APE8-dihe-in -91.45, 126.3 APE8-rot-in 315.62 APE67-dihe-in -56.65, -42.97 -87.39, -8.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.6426 APE9-dist-out 10.3699 L215R,T217E,R220K None None XRAY 3.302 0.236 0.288 A 285.0 256.0 6 26 20 6 [[133, 383]] 1.0 2wtw CAMK_AURKA_HUMAN CAMK 2.7e-81 278.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3E5AA O14965 125 389 403.0 VX6:500 Type1 Inactive DFGin 5.6075 15.6633 ABAminus -111.1, -40.76 -107.64, 114.77 -109.11, 20.41 286.45, 70.32 -57.36, -21.14 out-out out 10.6576 Saltbr-out 4.0692 HRD-in -71.98, -58.6 78.66, 11.03 out-in-in SNCoii in-in ActLoopNT-in 2.9414 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.8, 157.55 APE9-dihe-na 131.17, -154.51 APE8-dihe-in -121.72, 132.24 APE8-rot-in 299.23 APE67-dihe-in -74.97, -7.03 -28.17, -59.24 APE12-dist-in 8.1153 APE11-dist-in 10.9246 APE10-dist-in 5.2926 APE9-dist-in 3.622 None TPO288 TPO288 XRAY 2.3 0.206 0.256 A 268.0 265.0 0 26 26 0 [[133, 383]] 1.0 3e5a CAMK_AURKA_HUMAN CAMK 6.1e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2NP8A O14965 127 388 403.0 CC3:394 Type1 Inactive DFGin 5.2721 16.0857 ABAminus -73.9, -44.35 -158.46, -167.75 -112.0, 8.62 282.84, 84.47 66.12, -157.5 out-out out 10.2017 Saltbr-out 5.7237 HRD-in -71.77, -64.08 70.23, 8.33 out-out-out SNCooo out-out ActLoopNT-out 5.8433 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 150.46 APE8-rot-out 190.14 APE67-dihe-in -48.96, -32.22 -85.8, -12.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.25 0.246 0.283 A 272.0 256.0 6 26 20 6 [[133, 383]] 1.0 2np8 CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4BYIA O14965 126 388 403.0 FH3:1 Type1 Inactive DFGin 6.0053 15.1891 ABAminus -141.66, 21.53 -149.09, 143.7 -145.26, 27.8 296.46, 87.08 -78.42, -3.39 out-out out 10.1407 Saltbr-out 6.2062 HRD-in -80.19, -45.02 73.31, -36.35 out-in-out SNCoio in-out ActLoopNT-in 3.401 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -173.73 APE8-dihe-in -124.98, 116.87 APE8-rot-out 67.62 APE67-dihe-in -34.41, -45.4 -74.23, -30.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.2654 None None None XRAY 2.6 0.228 0.253 A 285.0 254.0 9 26 17 9 [[133, 383]] 1.0 4byi CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5ONEA O14965 127 391 403.0 9YQ:501 Type1 Inactive DFGin 4.5128 14.1346 ABAminus -105.31, -16.61 -81.48, 101.61 -122.99, 46.52 291.01, 77.01 95.14, 137.46 out-out out 11.5001 Saltbr-out 10.444 HRD-out -147.52, 134.98 -129.66, 144.77 out-out-out SNCooo out-out ActLoopNT-out 20.0081 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nooo APE10-dihe-na -112.99, 40.69 APE9-dihe-na -63.7, -27.3 APE8-dihe-out -60.7, -55.87 APE8-rot-out 51.63 APE67-dihe-in -60.28, -29.51 -61.01, -28.3 APE12-dist-none 999.0 APE11-dist-out 21.8053 APE10-dist-out 20.4835 APE9-dist-out 14.8011 None None None XRAY 2.6 0.211 0.26 A 285.0 257.0 8 26 18 8 [[133, 383]] 1.0 5one CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5DT0A O14965 127 390 403.0 SKE:401 Type1 Inactive DFGin 6.5507 16.3624 ABAminus -112.57, -43.63 -110.17, 94.56 -84.52, 17.21 279.45, 83.16 -58.42, -46.55 in-in in 9.1873 Saltbr-in 2.524 HRD-in -64.82, -50.09 61.67, 8.23 in-in-out SNCiio in-out ActLoopNT-in 3.1265 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 140.94 APE9-dihe-na -97.93, -126.07 APE8-dihe-in -73.71, 138.78 APE8-rot-in 266.46 APE67-dihe-in -37.39, -37.4 -82.91, -12.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.0428 APE9-dist-out 10.5837 None None None XRAY 2.15 0.211 0.225 A 273.0 259.0 5 26 21 5 [[133, 383]] 1.0 5dt0 CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3UODA O14965 124 389 403.0 0C3:1 Type1 Inactive DFGin 5.6651 15.2943 ABAminus -104.18, -60.78 -102.1, 108.06 -93.68, 11.03 272.93, 73.56 -44.02, -46.62 out-out out 10.1446 Saltbr-out 3.9294 HRD-in -79.65, -64.13 75.58, -18.62 out-in-out SNCoio in-out ActLoopNT-in 2.8871 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -98.48, 5.26 APE9-dihe-na 100.33, 142.31 APE8-dihe-in -67.88, 163.0 APE8-rot-out 221.97 APE67-dihe-in -55.37, -29.0 -54.05, -38.29 APE12-dist-in 12.8602 APE11-dist-in 9.3556 APE10-dist-in 6.3401 APE9-dist-out 6.0529 T287D None None XRAY 2.5 0.205 0.262 A 279.0 266.0 0 26 26 0 [[133, 383]] 1.0 3uod CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3UP2A O14965 124 389 403.0 0C8:1 Type1 Inactive DFGin 5.5895 15.653 ABAminus -108.06, -50.92 -103.25, 118.74 -107.45, 26.55 279.5, 74.04 -56.09, -30.67 out-out out 10.2757 Saltbr-out 3.8134 HRD-in -77.31, -62.33 77.13, 0.55 out-in-out SNCoio in-out ActLoopNT-in 2.9148 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -109.08, -27.68 APE9-dihe-na -96.57, -165.23 APE8-dihe-in -53.13, 139.16 APE8-rot-out 185.41 APE67-dihe-in -51.24, -31.12 -79.62, -9.19 APE12-dist-in 12.2079 APE11-dist-in 10.7242 APE10-dist-out 11.2807 APE9-dist-out 10.3496 T287D None None XRAY 2.3 0.208 0.249 A 279.0 266.0 0 26 26 0 [[133, 383]] 1.0 3up2 CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4DEAA O14965 124 389 403.0 NHI:504 Type1 Inactive DFGin 5.6269 15.4778 ABAminus -117.07, -34.04 -114.57, 105.92 -93.81, 27.91 288.17, 68.74 -50.21, -53.74 out-out out 10.4648 Saltbr-out 4.506 HRD-in -81.18, -46.28 61.2, 2.92 out-in-out SNCoio in-out ActLoopNT-in 2.8982 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -100.72, -36.57 APE9-dihe-na -78.58, -159.26 APE8-dihe-in -78.39, 167.49 APE8-rot-out 61.53 APE67-dihe-in -35.68, -36.82 -94.96, -2.96 APE12-dist-in 11.6423 APE11-dist-in 10.7252 APE10-dist-out 10.9639 APE9-dist-out 10.1521 T287D None None XRAY 2.45 0.218 0.262 A 279.0 266.0 0 26 26 0 [[133, 383]] 1.0 4dea CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5AAFA O14965 126 388 403.0 NL4:1001 Type1 Inactive DFGin 5.5084 15.7194 ABAminus -104.3, -69.43 -80.91, 136.22 -128.28, 19.02 282.29, 79.75 -69.18, -0.39 in-out in 9.8684 Saltbr-out 4.1218 HRD-in -74.86, -18.1 40.15, -49.95 out-in-out SNCoio in-out ActLoopNT-in 3.0723 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -175.93 APE8-dihe-in -99.34, 126.72 APE8-rot-out 58.55 APE67-dihe-in -42.07, -35.54 -95.24, -28.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.6377 C290A,C393A None None XRAY 2.78 0.242 0.287 A 285.0 254.0 9 26 17 9 [[133, 383]] 1.0 5aaf CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5AAGA O14965 127 388 403.0 6F2:1389 Type1 Inactive DFGin 5.5441 15.7627 ABAminus -109.01, -72.62 -67.08, 138.0 -133.77, 27.29 277.09, 81.16 -59.87, -35.8 out-none out 10.5895 Saltbr-none 999.0 HRD-in -77.69, -43.47 68.09, -55.11 none-in-out SNCnio in-out ActLoopNT-in 3.0359 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -177.15 APE8-dihe-in -100.49, 120.02 APE8-rot-out 59.29 APE67-dihe-in -48.12, -28.49 -91.69, -17.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2644 C290A,C393A None None XRAY 2.85 0.216 0.26 A 285.0 253.0 9 26 17 9 [[133, 383]] 1.0 5aag CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 6GRAA O14965 126 389 403.0 F8Z:501 Type1.5_Front Inactive DFGin 5.0091 16.6676 ABAminus -83.94, -29.2 -118.43, -178.38 -109.45, -4.58 278.61, 93.03 97.03, -121.48 out-out out 11.0182 Saltbr-out 9.6394 HRD-in -78.52, -51.2 68.01, 5.59 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 67.95 APE8-rot-none 999.0 APE67-dihe-in -48.59, -35.52 -71.59, -26.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.213 0.269 A 285.0 250.0 14 26 12 14 [[133, 383]] 1.0 6gra CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4BN1A O14965 126 388 403.0 ADP:1391 ATPlike Inactive DFGin 5.7586 14.9619 BLAminus -135.76, 176.64 57.4, 85.44 -97.06, 20.67 283.26, 70.95 -48.27, -40.43 in-in in 9.2277 Saltbr-in 2.7169 HRD-in -70.78, -55.66 70.88, -1.02 in-in-out SNCiio in-out ActLoopNT-in 2.8 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 16.45, -154.0 APE9-dihe-na 66.92, -173.53 APE8-dihe-in -66.46, 155.86 APE8-rot-out 182.79 APE67-dihe-in -44.49, -32.18 -93.83, -6.12 APE12-dist-in 12.1139 APE11-dist-in 8.7308 APE10-dist-out 13.7066 APE9-dist-out 11.1591 V174M TPO287,TPO288 TPO287,TPO288 XRAY 2.499 0.195 0.244 A 285.0 263.0 0 26 26 0 [[133, 383]] 1.0 4bn1 CAMK_AURKA_HUMAN CAMK 7.5e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 1MQ4A O14965 126 388 403.0 ADP:2001 ATPlike Inactive DFGin 5.607 15.2135 BLAminus -132.59, 179.34 62.49, 72.25 -91.07, 21.51 279.91, 70.01 -61.32, -27.71 in-in in 9.0551 Saltbr-in 2.8803 HRD-in -82.66, -49.31 72.48, -1.39 in-in-out SNCiio in-out ActLoopNT-in 2.9232 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -97.21, -164.83 APE9-dihe-na -146.02, -127.82 APE8-dihe-in -61.49, 131.42 APE8-rot-out 178.11 APE67-dihe-in -51.42, -34.84 -86.66, -6.25 APE12-dist-in 7.6815 APE11-dist-in 11.8468 APE10-dist-out 10.5866 APE9-dist-out 9.9776 None None None XRAY 1.9 0.229 0.273 A 272.0 261.0 2 26 24 2 [[133, 383]] 1.0 1mq4 CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5DNRA O14965 126 390 403.0 ATP:403 ATPlike Inactive DFGin 5.6553 15.0245 BLAminus -132.27, -179.72 60.78, 76.64 -90.12, 18.66 275.93, 74.44 -56.64, -35.89 in-in in 9.1663 Saltbr-in 2.7468 HRD-in -79.07, -53.73 71.53, 2.24 in-in-out SNCiio in-out ActLoopNT-in 2.9452 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -125.56, 5.88 APE9-dihe-na -79.83, -178.97 APE8-dihe-in -49.83, 123.63 APE8-rot-in 300.84 APE67-dihe-in -48.83, -30.32 -94.71, -13.22 APE12-dist-in 9.3475 APE11-dist-in 13.1152 APE10-dist-out 15.9471 APE9-dist-out 11.2037 None TPO288 TPO288 XRAY 1.95 0.206 0.226 A 272.0 265.0 0 26 26 0 [[133, 383]] 1.0 5dnr CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5DT3A O14965 127 390 403.0 ATP:403 ATPlike Inactive DFGin 5.7307 15.0475 BLAminus -138.47, 178.42 59.62, 78.35 -90.84, 24.83 281.41, 74.26 -61.06, -31.68 in-in in 9.4512 Saltbr-in 2.9168 HRD-in -69.42, -55.99 70.31, -3.53 in-in-out SNCiio in-out ActLoopNT-in 2.8923 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -112.53, -5.85 APE9-dihe-na -110.59, -164.26 APE8-dihe-in -61.03, 149.68 APE8-rot-out 193.86 APE67-dihe-in -45.37, -39.19 -93.82, -1.33 APE12-dist-in 12.1815 APE11-dist-in 10.015 APE10-dist-out 11.6945 APE9-dist-out 10.4874 None TPO287 TPO287 XRAY 2.33 0.21 0.243 A 273.0 264.0 0 26 26 0 [[133, 383]] 1.0 5dt3 CAMK_AURKA_HUMAN CAMK 6.5e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 1OL7A O14965 127 390 403.0 ADP:531 ATPlike Inactive DFGin 5.4287 15.0428 BLAminus -133.12, -167.56 48.98, 74.14 -88.94, 32.44 285.93, 64.91 -57.61, -36.14 in-in in 9.5058 Saltbr-in 3.0551 HRD-in -75.56, -48.34 63.05, 5.8 in-in-out SNCiio in-out ActLoopNT-in 2.9785 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -104.11, 138.56 APE9-dihe-na 156.93, 143.05 APE8-dihe-in -89.37, 102.83 APE8-rot-out 182.11 APE67-dihe-in -15.17, -56.94 -45.24, -37.82 APE12-dist-in 11.2666 APE11-dist-in 11.2056 APE10-dist-out 10.4649 APE9-dist-out 8.2689 None TPO287,TPO288 TPO287,TPO288 XRAY 2.75 0.257 0.296 A 282.0 264.0 0 26 26 0 [[133, 383]] 1.0 1ol7 CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5G15A O14965 126 390 403.0 ACP:1391 ATPlike Inactive DFGin 5.983 16.3862 BLAminus -138.69, -169.03 59.87, 67.73 -86.51, 18.94 284.94, 72.05 -48.14, -38.59 out-out out 10.2958 Saltbr-out 5.1725 HRD-in -73.28, -52.04 69.95, 14.4 out-in-in SNCoii in-in ActLoopNT-in 2.9265 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.64, 165.4 APE9-dihe-na 125.58, -148.7 APE8-dihe-in -133.46, 135.34 APE8-rot-in 292.83 APE67-dihe-in -71.67, -13.58 -36.11, -59.51 APE12-dist-in 10.3189 APE11-dist-in 11.1833 APE10-dist-in 5.6098 APE9-dist-in 3.4626 None None None XRAY 2.06 0.229 0.274 A 282.0 265.0 0 26 26 0 [[133, 383]] 1.0 5g15 CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2DWBA O14965 126 389 403.0 ANP:502 ATPlike Inactive DFGin 5.6048 15.1145 BLAminus -136.11, 177.41 60.85, 78.38 -89.15, 29.26 286.88, 68.88 -66.25, -4.03 in-in in 9.2398 Saltbr-in 3.1689 HRD-in -70.6, -46.07 60.68, 4.1 in-in-out SNCiio in-out ActLoopNT-in 3.0356 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -134.99, -178.03 APE9-dihe-na -132.27, -116.26 APE8-dihe-in -79.37, 134.9 APE8-rot-out 179.73 APE67-dihe-in -26.2, -44.84 -85.0, -15.78 APE12-dist-in 8.0361 APE11-dist-in 12.1391 APE10-dist-out 11.1616 APE9-dist-out 10.8267 None None MSE300,MSE305,MSE373 XRAY 2.5 0.227 0.275 A 285.0 262.0 2 26 24 2 [[133, 383]] 1.0 2dwb CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 6CPFA O14965 128 392 403.0 ACP:501 ATPlike Inactive DFGin 5.8515 16.0756 BLAminus -125.44, -173.01 51.86, 75.65 -92.36, 20.23 261.59, 77.98 -63.75, -18.06 out-none out 11.2478 Saltbr-none 999.0 HRD-in -104.84, -51.34 76.83, -36.49 none-in-out SNCnio in-out ActLoopNT-in 3.2019 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -168.9 APE8-dihe-in -78.28, 136.09 APE8-rot-out 59.9 APE67-dihe-in -54.01, -29.69 -75.21, 5.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7077 None None None XRAY 2.3 0.222 0.259 A 285.0 259.0 6 26 20 6 [[133, 383]] 1.0 6cpf CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5DRDA O14965 127 390 403.0 ATP:402 ATPlike Inactive DFGin 6.1794 15.4902 BLAminus -124.75, -173.07 54.37, 73.03 -91.89, 14.82 276.39, 76.92 -60.47, -27.86 in-in in 9.0942 Saltbr-in 2.7117 HRD-in -86.49, -50.72 75.89, 5.8 in-in-out SNCiio in-out ActLoopNT-in 3.0093 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -110.08 APE9-dihe-na -77.61, -136.85 APE8-dihe-in -63.84, 145.87 APE8-rot-out 199.39 APE67-dihe-in -52.56, -31.45 -96.52, -6.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.8473 APE9-dist-out 10.6226 T287A None None XRAY 2.13 0.209 0.262 A 273.0 259.0 5 26 21 5 [[133, 383]] 1.0 5drd CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4DEEA O14965 124 394 403.0 ADP:503 ATPlike Inactive DFGin 5.9771 15.579 BLAminus -131.54, -177.86 61.33, 72.14 -88.35, 17.45 278.56, 69.2 -56.76, -24.29 in-in in 9.2363 Saltbr-in 2.8355 HRD-in -80.53, -51.88 66.61, 1.43 in-in-out SNCiio in-out ActLoopNT-in 2.6858 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -125.87, -53.37 APE9-dihe-na -86.66, -134.63 APE8-dihe-in -80.8, 152.73 APE8-rot-out 187.03 APE67-dihe-in -37.34, -40.8 -92.92, -9.81 APE12-dist-in 12.1076 APE11-dist-in 10.7866 APE10-dist-out 10.7625 APE9-dist-out 10.5323 T287D None None XRAY 2.3 0.213 0.259 A 279.0 271.0 0 26 26 0 [[133, 383]] 1.0 4dee CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 6VPIA O14965 104 389 403.0 ANP:60601 ATPlike Inactive DFGin 5.4078 15.3189 BLAminus -130.78, 176.39 58.02, 80.51 -93.54, 25.65 284.58, 75.71 -64.44, -24.62 in-in in 9.8845 Saltbr-in 3.1969 HRD-in -68.95, -50.99 70.99, 3.21 in-in-out SNCiio in-out ActLoopNT-in 2.8207 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -142.04, 146.83 APE9-dihe-na 91.87, 167.2 APE8-dihe-in -74.18, 122.94 APE8-rot-in 319.25 APE67-dihe-in -55.59, -26.7 -100.93, -9.45 APE12-dist-in 10.0099 APE11-dist-in 12.8345 APE10-dist-out 16.1495 APE9-dist-out 20.0557 None None None XRAY 2.0 0.188 0.215 A 292.0 264.0 0 26 26 0 [[133, 383]] 1.0 6vpi CAMK_AURKA_HUMAN CAMK 6.9e-78 267.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4CEGA O14965 127 391 403.0 ADP:1392 ATPlike Inactive DFGin 6.3211 15.6655 BLAminus -126.79, -176.42 60.85, 65.85 -88.73, 20.26 276.07, 70.68 -62.71, -30.16 in-in in 8.907 Saltbr-in 2.7521 HRD-in -80.9, -50.34 70.05, 0.74 in-in-out SNCiio in-out ActLoopNT-in 2.8816 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -88.79, -42.25 APE9-dihe-na -103.79, -144.9 APE8-dihe-in -67.83, 148.92 APE8-rot-out 184.96 APE67-dihe-in -49.78, -34.34 -90.88, -2.74 APE12-dist-in 12.0347 APE11-dist-in 10.9906 APE10-dist-out 11.5002 APE9-dist-out 10.933 C290A,C393A TPO288 TPO288 XRAY 2.1 0.202 0.237 A 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 4ceg CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 1OL6A O14965 128 388 403.0 ATP:1388 ATPlike Inactive DFGin 5.8513 15.6403 BLAminus -135.92, 178.5 52.45, 77.03 -92.23, 24.52 292.21, 75.73 -61.17, -14.48 in-out in 9.9117 Saltbr-out 4.6692 HRD-in -62.99, -55.9 71.29, 3.18 out-in-none SNCoin in-none ActLoopNT-in 3.0994 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.06 APE8-rot-in 336.17 APE67-dihe-in -65.51, -21.75 -47.85, -55.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D274N None None XRAY 3.0 0.277 0.301 A 282.0 246.0 15 26 15 11 [[133, 383]] 1.0 1ol6 CAMK_AURKA_HUMAN CAMK 4.4e-79 271.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 6VPLA O14965 7 389 403.0 ANP:60602,R7D:60606 ATPlike,Allosteric Inactive DFGin 5.4712 15.7016 BLAminus -128.47, 179.47 64.6, 81.81 -95.02, 21.48 283.88, 78.68 -63.38, -17.61 out-out out 10.4098 Saltbr-out 4.4992 HRD-in -80.46, -54.34 74.63, 5.06 out-in-out SNCoio in-out ActLoopNT-in 2.9665 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -88.44, -6.25 APE9-dihe-na -62.06, -23.8 APE8-dihe-in -134.19, 108.37 APE8-rot-in 311.29 APE67-dihe-in -61.89, -28.27 -86.38, -9.29 APE12-dist-out 25.8944 APE11-dist-out 21.3249 APE10-dist-out 23.1598 APE9-dist-out 28.0042 None TPO288 TPO288 XRAY 1.86 0.169 0.201 A 292.0 262.0 4 26 22 4 [[133, 383]] 1.0 6vpl CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 6VPLB O14965 7 389 403.0 ANP:60601,R7D:60605 ATPlike,Allosteric Inactive DFGin 5.5835 16.0448 BLAminus -127.84, 176.75 65.51, 80.18 -93.8, 23.88 286.09, 77.69 -67.93, -15.19 out-out out 10.6562 Saltbr-out 4.5577 HRD-in -79.97, -52.06 71.02, 4.97 out-in-out SNCoio in-out ActLoopNT-in 2.9438 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -84.27, -7.56 APE9-dihe-na -59.65, -24.89 APE8-dihe-in -135.15, 99.87 APE8-rot-in 315.26 APE67-dihe-in -58.26, -30.91 -76.18, -13.07 APE12-dist-out 25.8592 APE11-dist-out 21.4014 APE10-dist-out 23.5627 APE9-dist-out 28.2448 None TPO288 TPO288 XRAY 1.86 0.169 0.201 B 292.0 262.0 4 26 22 4 [[133, 383]] 1.0 6vpl CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 6VPMA O14965 7 389 403.0 AMP:60602,R74:60603 ATPlike,Allosteric Inactive DFGin 5.5106 15.7854 BLAminus -126.3, 179.56 64.46, 79.19 -94.31, 22.45 283.25, 78.95 -62.44, -22.15 out-out out 10.4649 Saltbr-out 4.6318 HRD-in -82.12, -50.43 74.02, 3.7 out-in-out SNCoio in-out ActLoopNT-in 2.9505 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -94.21, -5.66 APE9-dihe-na -50.93, -40.67 APE8-dihe-in -122.63, 120.42 APE8-rot-out 167.52 APE67-dihe-in -61.47, -28.56 -78.55, -11.77 APE12-dist-out 25.8473 APE11-dist-out 21.3063 APE10-dist-out 23.1902 APE9-dist-out 28.0965 None TPO288 TPO288 XRAY 1.58 0.17 0.203 A 292.0 261.0 4 26 22 4 [[133, 383]] 1.0 6vpm CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 6VPMB O14965 7 389 403.0 AMP:60601,R74:60602 ATPlike,Allosteric Inactive DFGin 5.618 16.1711 BLAminus -126.47, 179.26 64.24, 79.8 -93.68, 23.42 285.18, 79.92 -68.14, -17.47 out-out out 10.727 Saltbr-out 4.7852 HRD-in -77.29, -52.49 74.53, -0.08 out-in-out SNCoio in-out ActLoopNT-in 2.9546 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -95.93, -6.99 APE9-dihe-na -61.27, -34.46 APE8-dihe-in -116.01, 94.69 APE8-rot-in 318.22 APE67-dihe-in -54.76, -31.62 -74.36, -14.23 APE12-dist-out 26.0157 APE11-dist-out 21.5194 APE10-dist-out 23.6303 APE9-dist-out 28.4313 None TPO288 TPO288 XRAY 1.58 0.17 0.203 B 292.0 261.0 4 26 22 4 [[133, 383]] 1.0 6vpm CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5ORLA O14965 127 391 403.0 ADP:401,A4W:407 ATPlike,Allosteric Inactive DFGin 7.0659 16.6489 BLAminus -127.84, -172.28 56.81, 60.19 -82.35, 15.9 271.2, 75.61 -63.85, -28.67 in-in in 9.0488 Saltbr-in 2.7502 HRD-in -78.27, -48.5 74.34, -1.48 in-in-out SNCiio in-out ActLoopNT-in 2.9772 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -99.11, -104.69 APE9-dihe-na -74.24, -110.44 APE8-dihe-in -76.15, 148.12 APE8-rot-out 189.45 APE67-dihe-in -56.74, -24.81 -85.95, -8.4 APE12-dist-in 12.0723 APE11-dist-in 10.971 APE10-dist-out 10.3882 APE9-dist-out 11.2888 C290A TPO288 TPO288 XRAY 1.69 0.206 0.238 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orl CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5ORNA O14965 127 391 403.0 ADP:401,A5E:404 ATPlike,Allosteric Inactive DFGin 5.6718 15.4032 BLAminus -130.34, -174.38 54.92, 79.97 -94.37, 17.54 279.26, 75.58 -55.07, -30.09 in-in in 9.3539 Saltbr-in 2.9285 HRD-in -81.32, -50.86 72.88, 0.4 in-in-out SNCiio in-out ActLoopNT-in 3.025 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -63.8, -59.63 APE9-dihe-na -97.49, -117.04 APE8-dihe-in -91.34, 143.03 APE8-rot-out 191.17 APE67-dihe-in -51.25, -26.05 -82.57, -15.54 APE12-dist-in 12.3855 APE11-dist-in 10.4017 APE10-dist-out 11.4938 APE9-dist-out 11.3568 None TPO288 TPO288 XRAY 2.19 0.203 0.262 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orn CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5OROA O14965 127 391 403.0 ADP:401,A5H:404 ATPlike,Allosteric Inactive DFGin 5.6776 15.3373 BLAminus -140.88, -178.26 60.46, 77.77 -94.07, 18.69 277.24, 76.82 -52.63, -39.97 in-in in 9.2726 Saltbr-in 3.0567 HRD-in -74.27, -52.41 74.24, -3.23 in-in-out SNCiio in-out ActLoopNT-in 2.8427 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -87.43, -63.56 APE9-dihe-na -103.72, -111.07 APE8-dihe-in -78.78, 141.92 APE8-rot-out 181.93 APE67-dihe-in -53.21, -24.39 -89.75, -10.63 APE12-dist-in 12.176 APE11-dist-in 10.5588 APE10-dist-out 11.0011 APE9-dist-out 11.5009 None TPO288 TPO288 XRAY 2.12 0.223 0.281 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5oro CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5ORPA O14965 127 391 403.0 ADP:401,A5K:404 ATPlike,Allosteric Inactive DFGin 5.8123 15.4919 BLAminus -139.84, -179.78 59.55, 79.52 -94.35, 18.72 278.85, 73.24 -45.22, -42.84 in-in in 9.3871 Saltbr-in 2.908 HRD-in -83.1, -49.94 72.65, -1.94 in-in-out SNCiio in-out ActLoopNT-in 3.0344 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -75.76, -64.68 APE9-dihe-na -107.0, -110.58 APE8-dihe-in -81.78, 136.28 APE8-rot-out 180.06 APE67-dihe-in -57.19, -28.31 -85.06, -6.26 APE12-dist-in 12.3511 APE11-dist-in 10.944 APE10-dist-out 10.7661 APE9-dist-out 11.3666 None TPO288 TPO288 XRAY 2.19 0.21 0.273 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orp CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5ORRA O14965 127 391 403.0 ADP:401,A5Q:404 ATPlike,Allosteric Inactive DFGin 5.6648 15.4968 BLAminus -133.78, -179.48 60.85, 73.72 -91.04, 29.58 281.03, 75.21 -67.99, -25.16 in-in in 9.4213 Saltbr-in 3.055 HRD-in -80.95, -50.87 71.36, -2.01 in-in-out SNCiio in-out ActLoopNT-in 3.0207 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -79.12, -78.89 APE9-dihe-na -94.43, -116.97 APE8-dihe-in -78.43, 147.39 APE8-rot-out 182.93 APE67-dihe-in -56.59, -23.94 -94.11, -3.91 APE12-dist-in 12.2613 APE11-dist-in 11.0201 APE10-dist-out 10.4273 APE9-dist-out 11.0664 None TPO288 TPO288 XRAY 2.09 0.202 0.256 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orr CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5ORSA O14965 127 391 403.0 ADP:401,A5W:404 ATPlike,Allosteric Inactive DFGin 5.9555 15.6826 BLAminus -133.47, -175.79 56.95, 73.99 -92.77, 17.89 276.34, 75.78 -60.0, -24.97 in-in in 9.1746 Saltbr-in 2.899 HRD-in -79.83, -50.16 70.98, -0.5 in-in-out SNCiio in-out ActLoopNT-in 3.0015 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -90.64, -79.2 APE9-dihe-na -92.74, -115.85 APE8-dihe-in -81.19, 144.15 APE8-rot-out 184.83 APE67-dihe-in -58.67, -28.41 -85.39, -4.34 APE12-dist-in 12.1926 APE11-dist-in 10.9556 APE10-dist-out 10.6259 APE9-dist-out 11.291 None TPO288 TPO288 XRAY 1.98 0.209 0.257 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5ors CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5ORTA O14965 127 391 403.0 ADP:401,A5Z:406 ATPlike,Allosteric Inactive DFGin 5.9989 15.7538 BLAminus -125.96, -170.73 54.43, 75.09 -90.85, 19.73 277.07, 68.86 -49.78, -34.73 in-in in 9.1957 Saltbr-in 3.0255 HRD-in -79.74, -50.38 68.95, 1.55 in-in-out SNCiio in-out ActLoopNT-in 3.0837 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -85.06, -64.36 APE9-dihe-na -96.27, -115.21 APE8-dihe-in -89.65, 146.92 APE8-rot-out 194.22 APE67-dihe-in -52.62, -22.53 -93.73, -12.57 APE12-dist-in 12.5307 APE11-dist-in 10.9187 APE10-dist-out 10.824 APE9-dist-out 11.0185 None TPO288 TPO288 XRAY 2.56 0.208 0.275 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5ort CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5ORVA O14965 127 391 403.0 ADP:401,A65:406 ATPlike,Allosteric Inactive DFGin 5.6645 15.44 BLAminus -136.16, -176.05 58.92, 71.82 -89.03, 22.25 278.38, 76.78 -63.69, -25.31 in-in in 9.2454 Saltbr-in 2.8863 HRD-in -82.57, -52.35 73.38, 1.05 in-in-out SNCiio in-out ActLoopNT-in 3.0056 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -75.39, -87.03 APE9-dihe-na -89.16, -112.46 APE8-dihe-in -77.62, 139.73 APE8-rot-out 181.74 APE67-dihe-in -57.59, -25.24 -84.67, -4.17 APE12-dist-in 12.3135 APE11-dist-in 10.8773 APE10-dist-out 10.4209 APE9-dist-out 11.2549 None TPO288 TPO288 XRAY 1.88 0.214 0.268 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orv CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5ORWA O14965 127 391 403.0 ADP:401,A6E:404 ATPlike,Allosteric Inactive DFGin 5.7064 15.413 BLAminus -131.01, -175.69 56.41, 78.46 -94.05, 21.38 277.67, 78.36 -59.98, -27.55 in-in in 9.316 Saltbr-in 3.0048 HRD-in -84.25, -51.01 70.55, 2.29 in-in-out SNCiio in-out ActLoopNT-in 3.0694 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -84.32, -59.08 APE9-dihe-na -102.85, -110.93 APE8-dihe-in -86.24, 134.05 APE8-rot-out 178.0 APE67-dihe-in -62.04, -25.17 -80.18, -4.89 APE12-dist-in 12.2689 APE11-dist-in 10.8105 APE10-dist-out 10.9798 APE9-dist-out 11.1995 None TPO288 TPO288 XRAY 2.0 0.217 0.27 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orw CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5ORXA O14965 127 391 403.0 ADP:401,A6H:404 ATPlike,Allosteric Inactive DFGin 5.4831 15.3325 BLAminus -135.37, -175.69 58.5, 74.51 -88.48, 21.31 281.01, 74.45 -55.7, -31.23 in-in in 9.3916 Saltbr-in 2.8871 HRD-in -84.87, -52.92 73.65, 2.44 in-in-out SNCiio in-out ActLoopNT-in 2.9566 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -81.41, -75.31 APE9-dihe-na -97.77, -112.93 APE8-dihe-in -77.56, 136.59 APE8-rot-out 185.81 APE67-dihe-in -60.3, -23.27 -81.45, -7.22 APE12-dist-in 12.2711 APE11-dist-in 10.9764 APE10-dist-out 10.2482 APE9-dist-out 10.9212 None TPO288 TPO288 XRAY 1.88 0.222 0.27 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orx CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5ORYA O14965 127 391 403.0 ADP:401,AY4:406 ATPlike,Allosteric Inactive DFGin 5.665 15.4321 BLAminus -133.35, -178.83 58.64, 81.27 -98.02, 26.99 280.05, 73.77 -66.34, -26.48 in-in in 9.4129 Saltbr-in 3.0153 HRD-in -83.1, -49.94 67.85, 0.8 in-in-out SNCiio in-out ActLoopNT-in 2.9683 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -85.35, -78.87 APE9-dihe-na -90.27, -119.1 APE8-dihe-in -76.79, 146.69 APE8-rot-out 180.58 APE67-dihe-in -53.43, -25.94 -95.91, -5.0 APE12-dist-in 12.4465 APE11-dist-in 11.0475 APE10-dist-out 10.7427 APE9-dist-out 11.1533 None TPO288 TPO288 XRAY 1.99 0.207 0.265 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5ory CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5ORZA O14965 127 391 403.0 ADP:401,A6W:407 ATPlike,Allosteric Inactive DFGin 5.6745 15.4067 BLAminus -135.57, -175.22 57.46, 80.66 -98.54, 24.2 276.77, 79.7 -65.5, -21.43 in-in in 9.2536 Saltbr-in 3.1111 HRD-in -80.39, -48.42 71.09, -2.39 in-in-out SNCiio in-out ActLoopNT-in 3.0623 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -82.59, -77.55 APE9-dihe-na -100.89, -113.21 APE8-dihe-in -76.47, 144.8 APE8-rot-out 177.65 APE67-dihe-in -57.19, -24.65 -94.21, -4.24 APE12-dist-in 12.3009 APE11-dist-in 10.8877 APE10-dist-out 10.4018 APE9-dist-out 11.2099 None TPO288 TPO288 XRAY 1.92 0.199 0.244 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orz CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5OS0A O14965 127 391 403.0 ADP:401,A6Z:404 ATPlike,Allosteric Inactive DFGin 5.6629 15.4407 BLAminus -133.76, -174.78 57.78, 75.99 -91.75, 21.09 277.99, 75.39 -60.35, -28.95 in-in in 9.311 Saltbr-in 2.7878 HRD-in -86.51, -49.56 71.53, 0.91 in-in-out SNCiio in-out ActLoopNT-in 2.9596 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -90.57, -76.63 APE9-dihe-na -103.27, -112.09 APE8-dihe-in -75.93, 143.74 APE8-rot-out 179.33 APE67-dihe-in -59.48, -25.37 -86.69, -3.69 APE12-dist-in 12.1557 APE11-dist-in 10.864 APE10-dist-out 10.2569 APE9-dist-out 11.2043 None TPO288 TPO288 XRAY 1.74 0.22 0.264 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5os0 CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5OS1A O14965 127 391 403.0 ADP:401,A7H:407 ATPlike,Allosteric Inactive DFGin 5.601 15.3207 BLAminus -135.04, -179.66 61.87, 77.96 -95.19, 22.65 277.87, 73.62 -63.45, -26.73 in-in in 9.2237 Saltbr-in 2.9199 HRD-in -84.64, -47.57 66.67, 4.82 in-in-out SNCiio in-out ActLoopNT-in 3.0164 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -71.95, -77.41 APE9-dihe-na -100.69, -116.41 APE8-dihe-in -72.42, 138.52 APE8-rot-out 177.77 APE67-dihe-in -60.13, -26.29 -83.6, -2.57 APE12-dist-in 12.2392 APE11-dist-in 10.8166 APE10-dist-out 10.5993 APE9-dist-out 11.2579 None TPO288 TPO288 XRAY 1.9 0.203 0.25 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5os1 CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5OS2A O14965 127 391 403.0 ADP:401,A7K:404 ATPlike,Allosteric Inactive DFGin 5.6983 15.5293 BLAminus -131.21, -175.25 58.7, 76.84 -90.56, 21.45 276.93, 76.69 -62.35, -9.35 in-in in 9.3094 Saltbr-in 2.9759 HRD-in -79.13, -51.53 72.78, 2.45 in-in-out SNCiio in-out ActLoopNT-in 3.0182 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -27.53 APE9-dihe-na -109.52, -133.64 APE8-dihe-in -78.79, 129.87 APE8-rot-out 174.59 APE67-dihe-in -60.88, -25.02 -78.66, -3.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.8302 APE9-dist-out 10.9565 None None None XRAY 1.92 0.213 0.251 A 265.0 261.0 4 26 22 4 [[133, 383]] 1.0 5os2 CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5OS3A O14965 127 391 403.0 ADP:401,A7N:404 ATPlike,Allosteric Inactive DFGin 5.8534 15.6154 BLAminus -132.65, -178.67 63.71, 72.3 -91.21, 21.81 276.12, 75.45 -58.53, -29.86 in-in in 9.1686 Saltbr-in 2.9283 HRD-in -82.57, -48.69 69.82, -0.73 in-in-out SNCiio in-out ActLoopNT-in 2.9663 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -97.05, -71.52 APE9-dihe-na -103.15, -115.69 APE8-dihe-in -76.83, 145.54 APE8-rot-out 186.8 APE67-dihe-in -55.71, -28.81 -87.14, -3.16 APE12-dist-in 12.1833 APE11-dist-in 10.9495 APE10-dist-out 10.3755 APE9-dist-out 11.239 None TPO288 TPO288 XRAY 1.81 0.203 0.238 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5os3 CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5OS4A O14965 127 391 403.0 ADP:401,A8H:404 ATPlike,Allosteric Inactive DFGin 5.5617 15.3883 BLAminus -130.51, -177.66 61.48, 75.55 -91.39, 22.5 279.03, 76.09 -60.73, -28.57 in-in in 9.2451 Saltbr-in 2.8621 HRD-in -82.71, -48.02 68.35, 3.92 in-in-out SNCiio in-out ActLoopNT-in 2.9591 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -77.92, -67.81 APE9-dihe-na -96.69, -121.48 APE8-dihe-in -75.57, 137.34 APE8-rot-out 180.49 APE67-dihe-in -57.86, -25.07 -81.82, -5.88 APE12-dist-in 12.2565 APE11-dist-in 10.8031 APE10-dist-out 10.9355 APE9-dist-out 11.2587 None TPO288 TPO288 XRAY 1.88 0.205 0.24 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5os4 CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5OS6A O14965 127 391 403.0 ADP:401,A7Q:404 ATPlike,Allosteric Inactive DFGin 6.0291 15.7815 BLAminus -126.13, -169.53 51.73, 76.81 -92.36, 19.58 272.42, 79.82 -57.78, -34.45 in-in in 9.2445 Saltbr-in 2.995 HRD-in -81.41, -52.88 69.05, 4.37 in-in-out SNCiio in-out ActLoopNT-in 3.0404 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -77.03, -70.53 APE9-dihe-na -90.32, -115.88 APE8-dihe-in -84.85, 141.6 APE8-rot-out 180.13 APE67-dihe-in -64.32, -26.41 -86.27, 0.74 APE12-dist-in 12.2131 APE11-dist-in 10.8263 APE10-dist-out 10.7401 APE9-dist-out 10.9916 None TPO288 TPO288 XRAY 2.2 0.216 0.277 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5os6 CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5OSEA O14965 127 391 403.0 ADP:401,A98:404 ATPlike,Allosteric Inactive DFGin 5.6464 15.4407 BLAminus -134.11, -176.47 59.39, 78.15 -96.43, 21.72 274.12, 77.75 -65.33, -24.45 in-in in 9.1368 Saltbr-in 2.8845 HRD-in -78.93, -49.87 70.59, 0.35 in-in-out SNCiio in-out ActLoopNT-in 2.9592 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -81.25, -72.54 APE9-dihe-na -105.09, -114.94 APE8-dihe-in -73.18, 141.65 APE8-rot-out 184.53 APE67-dihe-in -56.53, -26.26 -88.57, -5.48 APE12-dist-in 12.1504 APE11-dist-in 10.9758 APE10-dist-out 10.508 APE9-dist-out 11.2527 None TPO288 TPO288 XRAY 1.9 0.192 0.237 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5ose CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5OSFA O14965 127 391 403.0 ADP:401,A9E:404 ATPlike,Allosteric Inactive DFGin 5.7593 15.6562 BLAminus -131.88, -178.74 65.35, 71.33 -84.84, 21.28 278.92, 73.36 -65.0, -27.04 in-in in 9.3139 Saltbr-in 2.8266 HRD-in -85.08, -46.49 62.7, 8.17 in-in-out SNCiio in-out ActLoopNT-in 2.9651 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -87.68, -61.8 APE9-dihe-na -106.59, -110.06 APE8-dihe-in -85.81, 135.3 APE8-rot-out 180.39 APE67-dihe-in -56.65, -25.75 -79.56, -7.54 APE12-dist-in 12.2037 APE11-dist-in 10.6895 APE10-dist-out 10.9134 APE9-dist-out 11.4534 None TPO288 TPO288 XRAY 1.89 0.204 0.254 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5osf CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5OSDA O14965 125 391 403.0 ADP:401,A9B:404 ATPlike,Allosteric Inactive DFGin 5.672 15.4437 BLAminus -133.73, -178.01 59.76, 77.67 -95.6, 25.32 277.59, 73.38 -66.16, -23.93 in-in in 9.1535 Saltbr-in 2.9136 HRD-in -79.03, -50.3 71.01, -1.56 in-in-out SNCiio in-out ActLoopNT-in 3.0371 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -81.55, -62.64 APE9-dihe-na -107.55, -120.42 APE8-dihe-in -75.26, 143.45 APE8-rot-out 177.88 APE67-dihe-in -54.13, -27.04 -91.57, -4.8 APE12-dist-in 12.2502 APE11-dist-in 11.0743 APE10-dist-out 10.8059 APE9-dist-out 11.1972 None TPO288 TPO288 XRAY 1.99 0.198 0.239 A 267.0 267.0 0 26 26 0 [[133, 383]] 1.0 5osd CAMK_AURKA_HUMAN CAMK 7.4e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5OS5A O14965 125 392 403.0 ADP:401,A8K:404 ATPlike,Allosteric Inactive DFGin 5.536 15.2749 BLAminus -135.35, -174.05 58.1, 79.63 -93.47, 22.72 276.13, 73.04 -64.31, -25.3 in-in in 9.3797 Saltbr-in 2.8681 HRD-in -80.2, -52.69 73.71, 2.64 in-in-out SNCiio in-out ActLoopNT-in 2.8801 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -96.33, -47.43 APE9-dihe-na -104.6, -130.88 APE8-dihe-in -73.88, 139.12 APE8-rot-out 187.09 APE67-dihe-in -61.32, -25.92 -83.14, -4.09 APE12-dist-in 12.2806 APE11-dist-in 10.8451 APE10-dist-out 11.3572 APE9-dist-out 10.9535 None TPO288 TPO288 XRAY 1.74 0.199 0.236 A 268.0 268.0 0 26 26 0 [[133, 383]] 1.0 5os5 CAMK_AURKA_HUMAN CAMK 7.5e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 6R49A O14965 127 391 403.0 ADP:501,JSB:504 ATPlike,Allosteric Inactive DFGin 5.6142 15.4571 BLAminus -138.43, -175.42 57.6, 78.22 -94.44, 21.89 276.25, 76.24 -57.77, -33.65 in-in in 9.3806 Saltbr-in 2.8938 HRD-in -87.16, -51.58 76.44, -3.34 in-in-out SNCiio in-out ActLoopNT-in 3.1015 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -122.85 APE8-dihe-in -81.14, 140.15 APE8-rot-out 187.07 APE67-dihe-in -51.76, -30.76 -84.84, -7.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0529 C290A,C393A TPO288 TPO288 XRAY 2.209 0.194 0.24 A 285.0 260.0 5 26 21 5 [[133, 383]] 1.0 6r49 CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 6R4AA O14965 127 391 403.0 ADP:501,JRT:510 ATPlike,Allosteric Inactive DFGin 6.1565 15.9493 BLAminus -128.43, -176.18 59.16, 64.31 -84.29, 19.22 274.78, 74.05 -63.59, -28.66 in-in in 9.1016 Saltbr-in 2.8252 HRD-in -85.32, -47.41 69.85, -3.89 in-in-out SNCiio in-out ActLoopNT-in 3.0232 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -103.23, -102.89 APE9-dihe-na -87.4, -108.97 APE8-dihe-in -74.29, 145.29 APE8-rot-out 184.87 APE67-dihe-in -57.97, -25.59 -89.08, -1.69 APE12-dist-in 12.109 APE11-dist-in 10.8679 APE10-dist-out 9.9425 APE9-dist-out 11.4483 C290A,C393A TPO288 TPO288 XRAY 1.937 0.193 0.234 A 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 6r4a CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 6R4BA O14965 127 391 403.0 ADP:501,JSN:508 ATPlike,Allosteric Inactive DFGin 5.8943 15.6634 BLAminus -137.57, -177.62 60.57, 72.93 -89.1, 20.04 274.87, 75.15 -57.71, -33.47 in-in in 9.285 Saltbr-in 2.8908 HRD-in -83.52, -48.93 71.64, -3.16 in-in-out SNCiio in-out ActLoopNT-in 2.9599 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -86.33, -81.37 APE9-dihe-na -105.19, -110.27 APE8-dihe-in -73.56, 134.57 APE8-rot-out 182.29 APE67-dihe-in -52.75, -29.28 -80.52, -6.55 APE12-dist-in 12.1859 APE11-dist-in 10.9551 APE10-dist-out 10.1562 APE9-dist-out 11.3762 None TPO288 TPO288 XRAY 2.15 0.191 0.23 A 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 6r4b CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 6R4CA O14965 127 391 403.0 ADP:501,JRQ:507 ATPlike,Allosteric Inactive DFGin 6.0205 15.666 BLAminus -134.91, -179.34 60.98, 67.5 -85.83, 17.59 275.41, 71.94 -60.31, -30.9 in-in in 9.0676 Saltbr-in 2.7695 HRD-in -80.73, -51.78 76.01, -7.95 in-in-out SNCiio in-out ActLoopNT-in 2.8911 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -93.37, -96.1 APE9-dihe-na -98.19, -111.55 APE8-dihe-in -67.65, 142.09 APE8-rot-out 185.03 APE67-dihe-in -56.49, -28.95 -89.55, -1.14 APE12-dist-in 12.1917 APE11-dist-in 10.8889 APE10-dist-out 9.9307 APE9-dist-out 11.3954 C290A,C393A TPO288 TPO288 XRAY 2.04 0.188 0.226 A 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 6r4c CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 6R4DA O14965 127 391 403.0 ADP:501,JRW:505 ATPlike,Allosteric Inactive DFGin 5.4128 15.0606 BLAminus -136.32, -175.95 60.26, 82.3 -97.39, 21.73 280.16, 71.96 -61.32, -30.02 in-in in 9.3772 Saltbr-in 2.9356 HRD-in -84.35, -49.77 70.9, 2.54 in-in-out SNCiio in-out ActLoopNT-in 2.8984 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -109.88, -49.72 APE9-dihe-na -75.41, -134.11 APE8-dihe-in -89.35, 144.76 APE8-rot-out 181.5 APE67-dihe-in -55.31, -28.98 -80.38, -7.16 APE12-dist-in 12.1691 APE11-dist-in 10.3905 APE10-dist-out 11.4777 APE9-dist-out 10.5886 C290A,C393A TPO288 TPO288 XRAY 2.009 0.197 0.233 A 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 6r4d CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 8OF5A O14965 126 390 403.0 ADP:501,MPO:505 ATPlike,Allosteric Inactive DFGin 5.5613 15.0734 BLAminus -147.6, 177.58 63.9, 71.93 -82.69, 26.74 280.62, 72.05 -50.28, -40.53 in-in in 9.3763 Saltbr-in 2.7388 HRD-in -82.42, -53.84 70.6, 7.86 in-in-out SNCiio in-out ActLoopNT-in 2.9866 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na 65.3, 47.54 APE9-dihe-na -68.67, -176.82 APE8-dihe-in -69.15, 145.4 APE8-rot-out 54.1 APE67-dihe-in -51.26, -26.94 -88.64, -16.45 APE12-dist-out 18.2387 APE11-dist-out 20.5865 APE10-dist-out 23.6119 APE9-dist-out 27.9049 C290A,N332A,Q335A,C393A None None XRAY 1.97 0.186 0.235 A 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 8of5 CAMK_AURKA_HUMAN CAMK 3.1e-78 268.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 8C14A O14965 126 389 403.0 ADP:417,T5L:418,T0L:424 ATPlike,Allosteric,Allosteric Inactive DFGin 5.6307 14.7937 BLAminus -132.92, -178.64 59.29, 78.11 -87.91, 19.69 280.37, 75.08 -49.0, -40.94 in-in in 9.3228 Saltbr-in 2.7489 HRD-in -74.47, -52.26 68.72, 1.37 in-in-out SNCiio in-out ActLoopNT-in 2.8228 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -125.05, 2.89 APE9-dihe-na -76.04, 173.54 APE8-dihe-in -47.98, 133.45 APE8-rot-in 311.24 APE67-dihe-in -48.21, -32.08 -100.5, -9.07 APE12-dist-in 9.0819 APE11-dist-in 13.0305 APE10-dist-out 15.5933 APE9-dist-out 10.8925 None TPO288 TPO288 XRAY 1.93 0.182 0.194 A 272.0 264.0 0 26 26 0 [[133, 383]] 1.0 8c14 CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 8C15A O14965 126 388 403.0 ADP:401,T4C:404,T5L:405 ATPlike,Allosteric,Allosteric Inactive DFGin 5.6579 14.941 BLAminus -128.39, 176.76 57.21, 80.94 -90.54, 19.4 280.16, 77.64 -46.89, -42.14 in-in in 9.3562 Saltbr-in 2.9117 HRD-in -70.87, -48.88 65.09, -5.38 in-in-out SNCiio in-out ActLoopNT-in 2.8481 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -170.75 APE8-dihe-in -66.3, 161.07 APE8-rot-out 73.39 APE67-dihe-in -37.43, -35.12 -85.37, -6.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.144 C290A None None XRAY 2.41 0.199 0.207 A 265.0 259.0 4 26 22 4 [[133, 383]] 1.0 8c15 CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 8C1FA O14965 126 388 403.0 ADP:401,T5L:409,T2O:417 ATPlike,Allosteric,Allosteric Inactive DFGin 5.4716 14.6337 BLAminus -130.51, -175.69 56.68, 77.24 -89.7, 19.52 279.6, 79.65 -52.03, -32.93 in-in in 9.3024 Saltbr-in 2.8107 HRD-in -73.98, -48.91 69.8, -1.54 in-in-out SNCiio in-out ActLoopNT-in 2.8765 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -138.04 APE8-dihe-in -67.54, 164.12 APE8-rot-out 77.8 APE67-dihe-in -44.07, -35.33 -85.42, 0.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.5223 C290A None None XRAY 1.924 0.206 0.234 A 265.0 258.0 5 26 21 5 [[133, 383]] 1.0 8c1f CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 8C1IA O14965 126 388 403.0 ADP:401,T1L:404,T5L:405 ATPlike,Allosteric,Allosteric Inactive DFGin 5.5241 14.838 BLAminus -129.39, -179.52 57.08, 78.15 -89.88, 20.87 280.11, 76.95 -51.9, -37.66 in-in in 9.3549 Saltbr-in 2.9056 HRD-in -72.05, -49.31 67.09, -4.7 in-in-out SNCiio in-out ActLoopNT-in 2.8215 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -172.24 APE8-dihe-in -59.73, 161.33 APE8-rot-out 79.24 APE67-dihe-in -39.82, -36.32 -87.05, -1.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.3413 C290A None None XRAY 2.81 0.213 0.234 A 265.0 260.0 3 26 23 3 [[133, 383]] 1.0 8c1i CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5DN3A O14965 125 389 403.0 5DN:402,ATP:404 Allosteric,ATPlike Inactive DFGin 5.6992 15.0424 BLAminus -130.89, -174.42 55.28, 74.81 -88.98, 14.12 275.51, 75.93 -51.92, -35.15 in-in in 9.1659 Saltbr-in 2.7201 HRD-in -77.57, -53.05 71.13, 1.06 in-in-out SNCiio in-out ActLoopNT-in 2.9564 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -118.61, -13.13 APE9-dihe-na -74.86, -176.69 APE8-dihe-in -54.45, 125.21 APE8-rot-in 310.73 APE67-dihe-in -44.24, -34.14 -96.33, -16.24 APE12-dist-in 9.4351 APE11-dist-in 13.2348 APE10-dist-out 15.6674 APE9-dist-out 11.2317 None TPO288 TPO288 XRAY 2.05 0.192 0.203 A 272.0 265.0 0 26 26 0 [[133, 383]] 1.0 5dn3 CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 8C1EA O14965 127 388 403.0 T0X:401,ATP:403 Allosteric,ATPlike Inactive DFGin 5.7981 14.8074 BLAminus -150.0, 179.01 57.43, 76.53 -96.95, 20.99 278.49, 67.97 -56.09, -34.21 in-in in 9.1906 Saltbr-in 2.8469 HRD-in -74.81, -56.51 74.42, -5.07 in-in-out SNCiio in-out ActLoopNT-in 2.6152 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -165.45, 99.75 APE9-dihe-na -118.34, -95.63 APE8-dihe-in -111.54, 127.78 APE8-rot-in 354.95 APE67-dihe-in -38.77, -37.51 -96.45, -21.24 APE12-dist-in 9.259 APE11-dist-in 13.5443 APE10-dist-out 15.2592 APE9-dist-out 10.8956 None TPO288 TPO288 XRAY 2.798 0.176 0.239 A 272.0 262.0 0 26 26 0 [[133, 383]] 1.0 8c1e CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5DT4A O14965 127 390 403.0 5DN:402,ATP:403 Allosteric,ATPlike Inactive DFGin 6.0226 15.016 BLAminus -131.6, -179.1 56.58, 87.02 -103.91, 25.71 282.11, 78.42 -59.32, -42.3 in-in in 9.5441 Saltbr-in 3.0038 HRD-in -66.18, -52.21 66.74, -14.36 in-in-out SNCiio in-out ActLoopNT-in 2.9439 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -57.69 APE9-dihe-na -89.02, -152.47 APE8-dihe-in -67.56, 141.58 APE8-rot-out 191.42 APE67-dihe-in -59.88, -41.29 -85.27, 2.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.1589 APE9-dist-out 9.9725 None None None XRAY 2.86 0.193 0.256 A 273.0 259.0 5 26 21 5 [[133, 383]] 1.0 5dt4 CAMK_AURKA_HUMAN CAMK 6.5e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 8C1MA O14965 127 389 403.0 T4X:402,ADP:404 Allosteric,ATPlike Inactive DFGin 5.6001 15.2723 BLAminus -122.0, 174.82 64.71, 68.72 -82.42, 30.82 279.23, 73.39 -59.87, -38.7 in-in in 9.6473 Saltbr-in 3.0527 HRD-in -66.75, -51.37 63.02, 9.93 in-in-out SNCiio in-out ActLoopNT-in 2.8953 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -144.61, 52.2 APE9-dihe-na -98.47, -158.53 APE8-dihe-in -77.97, 114.41 APE8-rot-out 83.32 APE67-dihe-in -36.94, -36.23 -77.28, -23.95 APE12-dist-in 9.5276 APE11-dist-in 12.9895 APE10-dist-out 15.7549 APE9-dist-out 10.6188 None TPO288 TPO288 XRAY 2.84 0.253 0.269 A 273.0 263.0 0 26 26 0 [[133, 383]] 1.0 8c1m CAMK_AURKA_HUMAN CAMK 6.5e-80 274.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5DOSA O14965 127 390 403.0 5DN:402,ATP:403 Allosteric,ATPlike Inactive DFGin 5.9 15.0444 BLAminus -141.11, -178.41 56.44, 85.64 -101.51, 29.55 282.61, 75.97 -61.45, -42.65 in-in in 9.4934 Saltbr-in 2.8607 HRD-in -75.29, -42.25 59.65, -8.83 in-in-out SNCiio in-out ActLoopNT-in 3.0424 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -79.83 APE9-dihe-na -91.08, -144.18 APE8-dihe-in -65.26, 123.97 APE8-rot-out 190.75 APE67-dihe-in -25.49, -64.25 -63.86, -31.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.0331 APE9-dist-out 9.7933 T287A None None XRAY 2.98 0.201 0.273 A 273.0 259.0 5 26 21 5 [[133, 383]] 1.0 5dos CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5DR2A O14965 128 390 403.0 5E1:60401,ATP:60403 Allosteric,ATPlike Inactive DFGin 5.7419 15.1483 BLAminus -112.74, -178.24 59.1, 85.93 -103.74, 31.08 282.48, 80.94 -64.76, -39.96 in-in in 9.2247 Saltbr-in 2.8451 HRD-in -83.01, -54.44 78.2, -2.4 in-in-out SNCiio in-out ActLoopNT-in 2.8713 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -117.43, 59.62 APE9-dihe-na -131.57, -163.05 APE8-dihe-in -74.95, 143.42 APE8-rot-out 161.96 APE67-dihe-in -60.88, -32.64 -91.05, 11.96 APE12-dist-in 12.5259 APE11-dist-in 9.1209 APE10-dist-out 12.6318 APE9-dist-out 10.0391 T287A None None XRAY 2.46 0.225 0.285 A 273.0 263.0 0 26 26 0 [[133, 383]] 1.0 5dr2 CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 8C1DA O14965 127 388 403.0 T2F:401,ADP:402,T5L:405 Allosteric,ATPlike,Allosteric Inactive DFGin 5.5903 14.7701 BLAminus -129.39, 179.64 57.3, 80.97 -92.88, 23.53 280.13, 79.47 -56.16, -33.44 in-in in 9.3061 Saltbr-in 2.9364 HRD-in -72.1, -50.49 67.69, -1.24 in-in-out SNCiio in-out ActLoopNT-in 2.7964 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 144.85 APE8-dihe-in -64.26, 154.27 APE8-rot-out 88.6 APE67-dihe-in -39.49, -36.75 -82.32, -6.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.088 C290A None None XRAY 2.115 0.212 0.238 A 265.0 259.0 3 26 23 3 [[133, 383]] 1.0 8c1d CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 8C1GA O14965 127 388 403.0 T3I:401,ADP:402,T5L:406 Allosteric,ATPlike,Allosteric Inactive DFGin 5.5437 14.882 BLAminus -128.11, -179.39 58.87, 76.11 -85.79, 22.41 279.68, 78.85 -51.87, -42.67 in-in in 9.2229 Saltbr-in 2.92 HRD-in -78.13, -46.93 64.28, -1.01 in-in-out SNCiio in-out ActLoopNT-in 2.8594 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -158.88 APE8-dihe-in -70.7, 159.97 APE8-rot-out 74.34 APE67-dihe-in -36.07, -37.71 -84.84, -3.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.3547 C290A None None XRAY 1.96 0.2 0.225 A 265.0 258.0 4 26 22 4 [[133, 383]] 1.0 8c1g CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 8C1HA O14965 127 388 403.0 T3U:401,ADP:402,T5L:405 Allosteric,ATPlike,Allosteric Inactive DFGin 5.6033 14.806 BLAminus -133.2, 171.3 67.89, 80.13 -90.96, 20.95 279.09, 80.15 -47.86, -43.49 in-in in 9.2738 Saltbr-in 3.0016 HRD-in -69.34, -50.65 67.03, -6.54 in-in-out SNCiio in-out ActLoopNT-in 2.8653 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -157.54 APE8-dihe-in -70.83, 158.42 APE8-rot-out 74.14 APE67-dihe-in -36.91, -39.82 -81.98, -5.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.5277 C290A None None XRAY 2.233 0.213 0.245 A 265.0 258.0 4 26 22 4 [[133, 383]] 1.0 8c1h CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 8C1KA O14965 127 388 403.0 T4O:401,ADP:402,T5L:405 Allosteric,ATPlike,Allosteric Inactive DFGin 5.3967 14.7974 BLAminus -136.92, -175.3 58.28, 79.92 -93.28, 13.0 269.57, 89.35 -50.4, -38.71 in-in in 9.6032 Saltbr-in 3.1142 HRD-in -64.38, -56.58 69.39, -9.24 in-in-out SNCiio in-out ActLoopNT-in 3.0088 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 39.31, -114.48 APE9-dihe-na 117.85, -67.49 APE8-dihe-in -136.08, 128.66 APE8-rot-out 19.12 APE67-dihe-in -37.03, -29.23 -73.31, -14.52 APE12-dist-in 9.2582 APE11-dist-in 12.9138 APE10-dist-out 12.6881 APE9-dist-out 10.8352 C290A None None XRAY 2.43 0.219 0.242 A 273.0 262.0 0 26 26 0 [[133, 383]] 1.0 8c1k CAMK_AURKA_HUMAN CAMK 8e-79 270.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 8SSPA O14965 126 389 403.0 PDO:507,627:510 Allosteric,Type1 Inactive DFGin 5.8271 16.0973 BLAminus -128.28, -176.57 55.06, 88.12 -104.67, 28.54 279.82, 74.62 -68.31, -32.7 out-out out 10.4075 Saltbr-out 5.1218 HRD-in -77.88, -49.99 65.51, 20.52 out-in-in SNCoii in-in ActLoopNT-in 2.9682 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.81, 156.13 APE9-dihe-na 124.75, -152.05 APE8-dihe-in -113.82, 146.04 APE8-rot-in 319.01 APE67-dihe-in -74.25, -9.45 -51.04, -52.82 APE12-dist-in 10.2144 APE11-dist-in 11.1637 APE10-dist-in 5.5695 APE9-dist-in 3.5982 None None None XRAY 2.6 0.202 0.257 A 284.0 264.0 0 26 26 0 [[133, 383]] 1.0 8ssp CAMK_AURKA_HUMAN CAMK 7.6e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 6CPEA O14965 127 389 403.0 No_ligand No_ligand Inactive DFGin 5.8487 15.4403 BLAminus -129.83, -177.34 58.21, 74.96 -91.4, 25.99 287.47, 70.66 -51.13, -60.41 in-in in 9.4954 Saltbr-in 2.6354 HRD-in -74.98, -53.23 69.96, 5.5 in-in-out SNCiio in-out ActLoopNT-in 3.0171 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -168.54 APE8-rot-out 73.87 APE67-dihe-in -48.92, -35.31 -91.44, -3.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.45 0.218 0.254 A 285.0 256.0 7 26 19 7 [[133, 383]] 1.0 6cpe CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4J8NA O14965 125 390 403.0 No_ligand No_ligand Inactive DFGin 5.9253 16.1592 BLAminus -129.5, -176.93 54.9, 81.06 -100.42, 18.24 277.9, 77.09 -55.57, -42.6 in-in in 9.6503 Saltbr-in 3.0411 HRD-in -71.66, -48.7 72.48, -23.07 in-in-out SNCiio in-out ActLoopNT-in 3.0709 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioo APE10-dihe-na -108.65, -134.85 APE9-dihe-na 51.07, -90.35 APE8-dihe-out 166.34, 127.33 APE8-rot-out 177.69 APE67-dihe-out -103.98, -33.6 -75.82, 64.16 APE12-dist-in 11.4112 APE11-dist-in 11.2704 APE10-dist-out 11.1537 APE9-dist-out 10.413 None None None XRAY 3.135 0.188 0.234 A 279.0 266.0 0 26 26 0 [[133, 383]] 1.0 4j8n CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4J8NB O14965 125 390 403.0 No_ligand No_ligand Inactive DFGin 5.9082 16.2093 BLAminus -129.59, -174.78 53.22, 81.35 -99.27, 18.15 277.26, 76.69 -54.47, -45.17 in-in in 9.7192 Saltbr-in 3.006 HRD-in -72.1, -48.2 71.96, -19.42 in-in-out SNCiio in-out ActLoopNT-in 3.1111 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -94.27, -131.7 APE9-dihe-na 72.09, -72.86 APE8-dihe-out 115.97, 127.78 APE8-rot-out 202.98 APE67-dihe-in -54.47, -40.45 -100.94, 29.6 APE12-dist-in 11.4087 APE11-dist-in 11.0348 APE10-dist-out 10.938 APE9-dist-out 9.9423 None None None XRAY 3.135 0.188 0.234 B 279.0 266.0 0 26 26 0 [[133, 383]] 1.0 4j8n CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4J8NC O14965 125 390 403.0 No_ligand No_ligand Inactive DFGin 5.93 16.2969 BLAminus -130.96, -172.88 51.49, 76.65 -93.62, 21.08 277.44, 74.97 -50.35, -43.64 in-in in 9.7588 Saltbr-in 3.1568 HRD-in -75.43, -46.61 71.17, -20.57 in-in-out SNCiio in-out ActLoopNT-in 3.1709 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -100.15, -18.01 APE9-dihe-na -95.51, 167.33 APE8-dihe-in -58.1, 137.58 APE8-rot-out 194.0 APE67-dihe-in -58.5, -42.08 -97.99, 30.31 APE12-dist-in 11.516 APE11-dist-in 11.236 APE10-dist-out 11.0009 APE9-dist-out 9.9942 None None None XRAY 3.135 0.188 0.234 C 279.0 266.0 0 26 26 0 [[133, 383]] 1.0 4j8n CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4J8ND O14965 126 390 403.0 No_ligand No_ligand Inactive DFGin 5.9704 16.2752 BLAminus -130.78, -174.78 51.83, 76.2 -93.32, 22.06 277.06, 75.74 -52.13, -43.63 in-in in 9.6704 Saltbr-in 3.1674 HRD-in -75.14, -47.48 71.69, -20.75 in-in-out SNCiio in-out ActLoopNT-in 3.0974 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -97.15, -26.99 APE9-dihe-na -90.54, 167.49 APE8-dihe-in -56.97, 140.7 APE8-rot-out 192.37 APE67-dihe-in -54.7, -36.7 -101.24, 28.7 APE12-dist-in 11.4427 APE11-dist-in 11.1882 APE10-dist-out 11.1015 APE9-dist-out 10.1571 None None None XRAY 3.135 0.188 0.234 D 279.0 265.0 0 26 26 0 [[133, 383]] 1.0 4j8n CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 8JG8A O14965 127 389 403.0 C74:401 Type1 Inactive DFGin 5.933 15.8241 BLAminus -128.49, 174.99 59.88, 99.05 -108.87, 38.26 286.14, 82.22 -57.46, -43.7 out-out out 11.9975 Saltbr-out 6.1676 HRD-in -95.62, -54.63 73.57, -39.54 out-in-out SNCoio in-out ActLoopNT-in 2.9683 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 127.44 APE9-dihe-na -110.98, -144.43 APE8-dihe-in -54.82, 132.81 APE8-rot-out 40.07 APE67-dihe-in -46.54, -36.9 -94.8, -4.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.1933 APE9-dist-out 11.4335 None None None XRAY 2.9 0.24 0.27 A 263.0 254.0 9 26 18 8 [[133, 383]] 1.0 8jg8 CAMK_AURKA_HUMAN CAMK 5.7e-80 274.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3HA6A O14965 125 388 403.0 2JZ:60001 Type1 Inactive DFGin 5.6459 15.6001 BLAminus -141.58, -150.58 44.95, 71.07 -95.98, 24.45 275.33, 82.1 -69.8, -23.79 in-out in 9.8233 Saltbr-out 5.1728 HRD-in -80.25, -46.58 72.24, 2.41 out-in-in SNCoii in-in ActLoopNT-in 2.9331 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.19, 168.57 APE9-dihe-na 119.45, -143.59 APE8-dihe-in -142.6, 136.84 APE8-rot-in 301.05 APE67-dihe-in -73.19, -14.37 -23.68, -69.02 APE12-dist-in 7.8833 APE11-dist-in 11.0719 APE10-dist-in 5.4982 APE9-dist-in 3.5229 None TPO287,TPO288 TPO287,TPO288 XRAY 2.36 0.225 0.252 A 268.0 264.0 0 26 26 0 [[133, 383]] 1.0 3ha6 CAMK_AURKA_HUMAN CAMK 6.1e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3VAPA O14965 127 388 403.0 0FY:1 Type1 Inactive DFGin 7.0112 16.5649 BLAminus -124.23, 172.43 53.89, 74.52 -90.45, 3.76 278.46, 77.35 -61.19, -14.68 in-in in 9.3773 Saltbr-in 2.8664 HRD-in -70.63, -46.43 60.81, 3.63 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 139.0 APE8-dihe-in -69.08, 141.35 APE8-rot-out 192.77 APE67-dihe-in -34.3, -47.94 -84.11, -19.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.0909 None None None XRAY 2.66 0.205 0.246 A 272.0 249.0 13 26 13 13 [[133, 383]] 1.0 3vap CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2W1CA O14965 127 389 403.0 L0C:61391 Type1 Inactive DFGin 5.8817 15.7724 BLAminus -97.54, -171.65 46.97, 95.02 -107.87, 39.71 281.94, 64.97 -60.69, -63.22 out-out out 10.0089 Saltbr-out 4.9609 HRD-in -80.1, -60.42 81.68, -30.47 out-in-out SNCoio in-out ActLoopNT-in 2.6291 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -60.97, 82.12 APE9-dihe-na -172.55, 143.93 APE8-dihe-in -52.57, 121.38 APE8-rot-out 184.61 APE67-dihe-in -46.28, -28.66 -83.22, -14.63 APE12-dist-in 11.6996 APE11-dist-out 14.9012 APE10-dist-out 14.0995 APE9-dist-out 10.7258 None TPO287,TPO288 TPO287,TPO288 XRAY 3.24 0.246 0.288 A 275.0 263.0 0 26 26 0 [[133, 383]] 1.0 2w1c CAMK_AURKA_HUMAN CAMK 6.7e-80 274.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2W1DA O14965 127 389 403.0 L0D:61391 Type1 Inactive DFGin 5.6701 15.6371 BLAminus -98.71, 177.07 59.81, 110.8 -129.83, 40.36 283.05, 72.78 -60.79, -58.22 in-out in 9.7057 Saltbr-out 4.7121 HRD-in -85.97, -78.13 96.93, -30.07 out-in-out SNCoio in-out ActLoopNT-in 2.8117 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 157.63 APE8-dihe-in -55.14, 99.56 APE8-rot-out 187.42 APE67-dihe-in -48.58, -23.35 -66.04, -18.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.1651 None None None XRAY 2.97 0.241 0.308 A 275.0 251.0 12 26 15 11 [[133, 383]] 1.0 2w1d CAMK_AURKA_HUMAN CAMK 6.7e-80 274.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2W1EA O14965 127 389 403.0 L0E:61390 Type1 Inactive DFGin 5.3343 15.2815 BLAminus -88.39, 176.43 54.42, 134.09 -145.65, 35.35 288.57, 71.15 -59.93, -38.53 out-out out 10.0778 Saltbr-out 4.8837 HRD-in -93.32, -52.74 80.56, -19.82 out-in-out SNCoio in-out ActLoopNT-in 2.7346 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 153.28 APE8-dihe-in -60.09, 131.73 APE8-rot-out 186.14 APE67-dihe-in -42.44, -28.83 -84.72, -20.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.4643 None None None XRAY 2.93 0.237 0.302 A 275.0 252.0 11 26 15 11 [[133, 383]] 1.0 2w1e CAMK_AURKA_HUMAN CAMK 6.7e-80 274.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2W1FA O14965 127 389 403.0 L0F:61390 Type1 Inactive DFGin 5.6549 15.7027 BLAminus -96.26, 172.45 62.06, 107.69 -118.91, 38.89 289.12, 66.42 -59.62, -48.4 out-out out 10.1385 Saltbr-out 5.1197 HRD-in -78.79, -54.88 78.03, -25.41 out-in-out SNCoio in-out ActLoopNT-in 2.6762 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -157.03 APE8-dihe-in -58.47, 105.92 APE8-rot-out 190.33 APE67-dihe-in -42.4, -27.58 -64.36, -20.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7745 None None None XRAY 2.85 0.246 0.348 A 275.0 253.0 10 26 16 10 [[133, 383]] 1.0 2w1f CAMK_AURKA_HUMAN CAMK 6.7e-80 274.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2W1GA O14965 127 389 403.0 L0G:61390 Type1 Inactive DFGin 5.7066 15.9532 BLAminus -102.36, -172.29 37.95, 92.18 -96.86, 32.84 280.6, 71.33 -53.02, -62.72 in-out in 9.8021 Saltbr-out 4.5733 HRD-in -76.37, -58.52 85.2, -46.3 out-in-out SNCoio in-out ActLoopNT-in 2.7065 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 171.28 APE8-dihe-in -49.55, 126.01 APE8-rot-out 191.62 APE67-dihe-in -58.12, -27.65 -91.48, -7.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.4433 None TPO287,TPO288 TPO287,TPO288 XRAY 2.71 0.229 0.297 A 275.0 254.0 9 26 17 9 [[133, 383]] 1.0 2w1g CAMK_AURKA_HUMAN CAMK 6.7e-80 274.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5ZANA O14965 127 389 403.0 9A6:501 Type1 Inactive DFGin 5.9215 15.7552 BLAminus -92.99, 175.48 46.37, 87.77 -88.95, 50.65 283.16, 69.59 -62.46, -35.37 out-none out 10.6249 Saltbr-none 999.0 HRD-in -84.0, -47.07 74.85, -53.4 none-in-out SNCnio in-out ActLoopNT-in 2.8869 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -158.12 APE8-dihe-in -77.87, 151.9 APE8-rot-out 71.81 APE67-dihe-in -45.51, -33.68 -101.83, 2.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1205 None None None XRAY 2.85 0.256 0.281 A 281.0 258.0 5 26 21 5 [[133, 383]] 1.0 5zan CAMK_AURKA_HUMAN CAMK 7.3e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4O0SA O14965 126 391 403.0 ADN:500 Type1 Inactive DFGin 6.0576 16.5586 BLAminus -149.62, -178.05 57.82, 65.99 -83.76, 4.5 260.08, 87.32 -48.25, -52.63 out-out out 10.5115 Saltbr-out 4.1117 HRD-in -67.13, -53.86 77.45, -15.34 out-in-out SNCoio in-out ActLoopNT-in 2.9445 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -80.39, -35.33 APE9-dihe-na -145.46, 176.17 APE8-dihe-in -59.32, 141.88 APE8-rot-out 196.74 APE67-dihe-in -51.21, -41.15 -95.86, -1.7 APE12-dist-in 12.4771 APE11-dist-in 13.4802 APE10-dist-out 10.7317 APE9-dist-out 11.0274 None None None XRAY 2.5 0.238 0.25 A 282.0 265.0 1 26 25 1 [[133, 383]] 1.0 4o0s CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2XNGA O14965 127 390 403.0 A0H:1391 Type1 Inactive DFGin 5.4826 15.5926 BLAminus -120.46, 176.57 56.36, 70.43 -73.62, 38.13 281.39, 65.5 -44.8, -64.31 in-out in 9.9179 Saltbr-out 4.1567 HRD-in -72.76, -59.76 78.84, -21.18 out-in-none SNCoin in-none ActLoopNT-in 3.1002 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -31.34 APE8-rot-in 245.35 APE67-dihe-in -47.83, -38.92 -81.58, -10.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.605 0.224 0.271 A 283.0 254.0 10 26 16 10 [[133, 383]] 1.0 2xng CAMK_AURKA_HUMAN CAMK 7.5e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4JAJA O14965 125 389 403.0 XU1:900 Type1 Inactive DFGin 5.7863 15.2661 BLAminus -130.79, -179.22 60.79, 74.26 -92.96, 19.38 279.35, 69.28 -57.12, -30.9 in-in in 9.3292 Saltbr-in 3.5366 HRD-in -77.96, -53.2 74.51, -4.28 in-in-out SNCiio in-out ActLoopNT-in 2.9018 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -121.8, 178.09 APE9-dihe-na -147.27, -129.97 APE8-dihe-in -58.84, 128.06 APE8-rot-out 191.16 APE67-dihe-in -49.67, -35.58 -96.31, -4.37 APE12-dist-in 11.235 APE11-dist-in 12.4446 APE10-dist-out 11.4822 APE9-dist-out 10.8381 None None None XRAY 2.7 0.238 0.323 A 284.0 265.0 0 26 26 0 [[133, 383]] 1.0 4jaj CAMK_AURKA_HUMAN CAMK 7.6e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2X6DA O14965 126 388 403.0 X6D:1391 Type1 Inactive DFGin 5.9409 15.0877 BLAminus -133.34, 178.89 66.11, 63.22 -78.84, 41.16 290.11, 72.3 -67.23, -32.17 in-out in 9.7614 Saltbr-out 3.7055 HRD-in -67.43, -47.15 74.62, -4.79 out-in-out SNCoio in-out ActLoopNT-in 2.9537 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -30.7 APE9-dihe-na 132.04, 170.08 APE8-dihe-in -58.22, 141.84 APE8-rot-out 194.18 APE67-dihe-in -56.15, -39.96 -97.87, -10.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.8166 APE9-dist-out 10.3813 None None None XRAY 2.796 0.22 0.264 A 285.0 255.0 8 26 22 4 [[133, 383]] 1.0 2x6d CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2X6EA O14965 126 388 403.0 YM4:1389 Type1 Inactive DFGin 5.3479 14.229 BLAminus -133.54, -165.49 47.01, 97.41 -106.94, 55.35 290.48, 60.79 -55.55, -43.91 in-out in 9.6199 Saltbr-out 3.9324 HRD-in -76.72, -65.71 73.76, 16.48 out-in-out SNCoio in-out ActLoopNT-in 2.9886 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 133.39 APE8-rot-out 167.74 APE67-dihe-in -39.2, -32.78 -108.28, -16.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.35 0.231 0.299 A 285.0 249.0 14 26 15 11 [[133, 383]] 1.0 2x6e CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4ZS0A O14965 127 388 403.0 4QV:501 Type1 Inactive DFGin 5.7775 15.3382 BLAminus -135.77, -170.35 51.72, 73.89 -87.94, 25.14 280.59, 69.39 -52.43, -36.14 out-out out 10.0384 Saltbr-out 4.0538 HRD-in -78.33, -50.96 66.12, -1.97 out-in-none SNCoin in-none ActLoopNT-in 2.8481 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 56.86 APE8-rot-in 353.63 APE67-dihe-in -54.02, -31.18 -108.57, -3.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.205 0.251 A 285.0 257.0 5 26 21 5 [[133, 383]] 1.0 4zs0 CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 6I2UA O14965 127 391 403.0 COA:501 Type1 Inactive DFGin 5.5262 14.9893 BLAminus -140.44, 177.56 64.83, 76.33 -90.26, 27.46 278.08, 68.91 -57.42, -31.8 in-in in 9.1646 Saltbr-in 2.9821 HRD-in -75.81, -51.2 63.39, 7.96 in-in-out SNCiio in-out ActLoopNT-in 2.9162 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -63.93, -34.08 APE9-dihe-na -96.67, -156.35 APE8-dihe-in -64.78, 150.87 APE8-rot-out 178.16 APE67-dihe-in -46.91, -34.21 -90.55, -4.34 APE12-dist-in 11.8012 APE11-dist-in 10.3 APE10-dist-out 11.1914 APE9-dist-out 10.2286 None TPO287,TPO288 TPO287,TPO288 XRAY 2.5 0.207 0.252 A 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 6i2u CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2XRUA O14965 126 389 403.0 400:1389 Type1 Inactive DFGin 6.1494 15.6457 BLAminus -125.16, 155.4 69.4, 129.42 -125.84, -55.47 276.35, 73.58 -8.05, 69.57 in-out in 9.97 Saltbr-out 4.3638 HRD-in -88.84, -45.6 72.75, -79.27 out-in-out SNCoio in-out ActLoopNT-in 2.9362 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 173.9 APE9-dihe-na 96.75, -152.28 APE8-dihe-in -102.76, 132.26 APE8-rot-in 267.24 APE67-dihe-in -30.79, -36.85 -72.99, -23.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.2081 APE9-dist-out 12.1191 T288E None None XRAY 2.9 0.247 0.344 A 280.0 254.0 10 26 16 10 [[133, 383]] 1.0 2xru CAMK_AURKA_HUMAN CAMK 1.7e-79 272.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3UO4A O14965 124 389 403.0 0C0:1 Type1 Inactive DFGin 6.2315 16.3784 BLAminus -126.04, -172.68 53.05, 69.73 -90.42, 6.21 269.6, 80.64 -48.08, -48.65 out-out out 10.0827 Saltbr-out 3.6201 HRD-in -70.53, -55.35 72.71, -18.06 out-in-out SNCoio in-out ActLoopNT-in 2.9804 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -118.54, -77.7 APE9-dihe-na -66.0, 113.52 APE8-dihe-out 41.71, -150.3 APE8-rot-in 344.62 APE67-dihe-in -48.42, -37.12 -114.97, -5.05 APE12-dist-in 11.8382 APE11-dist-in 10.7213 APE10-dist-out 10.0956 APE9-dist-out 9.2219 T287D None None XRAY 2.45 0.22 0.257 A 279.0 266.0 0 26 26 0 [[133, 383]] 1.0 3uo4 CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3UO5A O14965 124 390 403.0 0BX:501 Type1 Inactive DFGin 5.7654 15.6342 BLAminus -112.49, -174.84 56.04, 76.01 -85.73, 17.59 274.77, 67.57 -44.32, -44.34 in-out in 9.8969 Saltbr-out 4.1143 HRD-in -75.88, -52.17 75.0, -19.1 out-in-out SNCoio in-out ActLoopNT-in 2.7873 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -81.4, -63.65 APE9-dihe-na -91.09, -150.37 APE8-dihe-in -65.51, 136.03 APE8-rot-out 189.54 APE67-dihe-in -47.26, -39.02 -76.56, -5.95 APE12-dist-in 12.4918 APE11-dist-in 10.9019 APE10-dist-out 9.6516 APE9-dist-out 10.0285 T287D None None XRAY 2.701 0.22 0.273 A 279.0 267.0 0 26 26 0 [[133, 383]] 1.0 3uo5 CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3UP7A O14965 124 387 403.0 0C9:1 Type1 Inactive DFGin 5.8193 16.3646 BLAminus -130.09, 178.76 54.57, 64.0 -79.21, 24.67 284.67, 66.9 -53.78, -49.48 in-out in 9.968 Saltbr-out 3.6332 HRD-in -77.47, -60.24 71.29, 19.44 out-in-out SNCoio in-out ActLoopNT-in 3.0058 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -38.78, -81.56 APE9-dihe-na -54.71, -160.19 APE8-dihe-in -68.17, 153.89 APE8-rot-out 200.11 APE67-dihe-in -39.24, -30.76 -95.24, -4.8 APE12-dist-in 11.5263 APE11-dist-in 9.7601 APE10-dist-out 10.8795 APE9-dist-out 10.3866 T287D None None XRAY 3.05 0.233 0.292 A 279.0 264.0 0 26 26 0 [[133, 383]] 1.0 3up7 CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4DEBA O14965 125 388 403.0 NHJ:501 Type1 Inactive DFGin 5.8906 15.8517 BLAminus -118.01, 177.65 55.3, 79.43 -92.09, 27.01 282.13, 72.04 -55.45, -60.69 out-out out 10.0658 Saltbr-out 5.3839 HRD-in -81.24, -53.46 65.85, 22.78 out-in-out SNCoio in-out ActLoopNT-in 2.9159 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -66.58, 171.46 APE9-dihe-na -61.86, -44.53 APE8-dihe-in -110.19, 126.78 APE8-rot-in 317.95 APE67-dihe-in -22.11, -26.3 -79.6, -25.01 APE12-dist-in 11.9502 APE11-dist-in 10.8791 APE10-dist-out 8.6089 APE9-dist-out 11.7347 T287D None None XRAY 3.05 0.224 0.283 A 279.0 264.0 0 26 26 0 [[133, 383]] 1.0 4deb CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4DEDA O14965 124 388 403.0 NHU:501 Type1 Inactive DFGin 6.072 16.0816 BLAminus -138.76, 173.27 68.31, 59.98 -87.91, 21.59 291.07, 72.61 -64.04, -43.33 in-out in 9.4883 Saltbr-out 4.3842 HRD-in -67.29, -48.42 56.74, 25.08 out-in-out SNCoio in-out ActLoopNT-in 2.8551 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -130.4, 153.53 APE9-dihe-na -61.97, -49.69 APE8-dihe-in -129.11, 146.11 APE8-rot-out 199.74 APE67-dihe-in -53.92, -43.68 -92.26, 7.7 APE12-dist-in 12.4778 APE11-dist-in 12.0621 APE10-dist-out 8.768 APE9-dist-out 10.6151 T287D None None XRAY 3.05 0.224 0.282 A 279.0 265.0 0 26 26 0 [[133, 383]] 1.0 4ded CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4JBOA O14965 126 391 403.0 WPH:501 Type1 Inactive DFGin 6.9176 16.3349 BLAminus -121.96, 170.2 69.47, 92.47 -109.1, 25.94 282.47, 79.53 -73.3, -12.56 out-out out 10.5859 Saltbr-out 7.2839 HRD-in -69.78, -56.56 69.03, 0.72 out-in-out SNCoio in-out ActLoopNT-in 3.2014 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -88.96, 151.68 APE9-dihe-na 80.94, 165.59 APE8-dihe-in -59.72, 148.42 APE8-rot-out 55.11 APE67-dihe-in -45.81, -36.47 -90.07, -0.97 APE12-dist-in 7.5558 APE11-dist-in 12.071 APE10-dist-out 13.0397 APE9-dist-out 11.3997 T288D None None XRAY 2.493 0.221 0.236 A 279.0 266.0 0 26 26 0 [[133, 383]] 1.0 4jbo CAMK_AURKA_HUMAN CAMK 1.6e-79 272.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3NRMA O14965 126 388 403.0 NRM:1 Type1 Inactive DFGin 6.0716 15.0961 BLAminus -130.09, -178.19 51.16, 66.82 -80.62, 35.58 277.25, 74.79 -64.12, -46.77 in-in in 9.4352 Saltbr-in 3.4443 HRD-in -74.32, -41.78 69.11, -35.94 in-in-out SNCiio in-out ActLoopNT-in 2.8743 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -92.01, -151.58 APE9-dihe-na 69.72, -164.73 APE8-dihe-in -74.0, 133.98 APE8-rot-out 208.3 APE67-dihe-in -38.38, -36.32 -102.81, -1.38 APE12-dist-out 6.7273 APE11-dist-in 10.5789 APE10-dist-out 13.3005 APE9-dist-out 11.7 T287A,T288A None None XRAY 3.05 0.223 0.258 A 283.0 263.0 0 26 26 0 [[133, 383]] 1.0 3nrm CAMK_AURKA_HUMAN CAMK 4.7e-79 271.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3R21A O14965 127 389 403.0 D36:1 Type1 Inactive DFGin 6.4052 16.2492 BLAminus -119.2, 169.1 74.52, 71.15 -87.23, 26.31 291.35, 83.38 -45.72, -73.9 out-out out 10.143 Saltbr-out 3.6157 HRD-in -70.84, -47.21 71.45, -18.55 out-in-out SNCoio in-out ActLoopNT-in 3.0202 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na 106.81, 117.36 APE9-dihe-na 96.25, 137.51 APE8-dihe-in -45.73, 125.62 APE8-rot-out 178.81 APE67-dihe-in -38.05, -36.45 -80.95, -20.64 APE12-dist-none 999.0 APE11-dist-out 16.1671 APE10-dist-out 13.0563 APE9-dist-out 10.6547 T287D,T288D None None XRAY 2.9 0.26 0.305 A 271.0 254.0 9 26 17 9 [[133, 383]] 1.0 3r21 CAMK_AURKA_HUMAN CAMK 1.8e-79 272.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5AADA O14965 127 388 403.0 5GX:1389 Type1 Inactive DFGin 5.2465 15.0832 BLAminus -160.19, -169.78 46.44, 81.28 -88.9, 36.75 281.82, 83.2 -69.2, -12.18 in-in in 9.6596 Saltbr-in 3.5063 HRD-in -67.01, -43.23 68.2, -42.63 in-in-out SNCiio in-out ActLoopNT-in 2.9077 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 148.29 APE8-rot-out 201.58 APE67-dihe-in -45.45, -35.82 -107.8, -3.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C290A,C393A None None XRAY 3.1 0.205 0.283 A 285.0 252.0 10 26 16 10 [[133, 383]] 1.0 5aad CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2XNEA O14965 127 388 403.0 ASH:1389 Type1 Inactive DFGin 5.6738 14.9931 BLAminus -132.18, -174.52 57.91, 85.26 -105.96, 29.74 295.12, 67.89 -63.37, -29.37 out-out out 10.2605 Saltbr-out 4.6119 HRD-in -76.3, -55.45 66.89, 8.78 out-in-out SNCoio in-out ActLoopNT-in 3.2762 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 145.72 APE8-rot-out 185.25 APE67-dihe-in -38.84, -32.2 -88.97, -18.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D274N None None XRAY 2.8 0.24 0.281 A 272.0 246.0 16 26 17 9 [[133, 383]] 1.0 2xne CAMK_AURKA_HUMAN CAMK 3.8e-79 271.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5DR9A O14965 127 390 403.0 SKE:401,5E2:402 Type1,Allosteric Inactive DFGin 6.2605 16.4955 BLAminus -123.32, -163.78 43.59, 60.53 -66.54, -12.27 260.09, 81.94 -59.8, 149.1 out-out out 10.8322 Saltbr-out 5.8361 HRD-in -75.67, -56.88 79.45, -32.13 out-out-out SNCooo out-out ActLoopNT-out 3.7494 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 153.82 APE9-dihe-na -93.74, -139.43 APE8-dihe-in -48.63, 139.94 APE8-rot-in 276.28 APE67-dihe-in -58.38, -35.92 -97.04, 14.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.1214 APE9-dist-out 10.8202 T287A None None XRAY 2.47 0.227 0.262 A 273.0 257.0 7 26 19 7 [[133, 383]] 1.0 5dr9 CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3M11A O14965 126 391 403.0 AKI:1 Type1.5_Front Inactive DFGin 6.9635 16.7044 BLAminus -121.88, 165.26 64.27, 67.3 -73.83, 6.74 288.37, 76.5 -59.9, -23.24 out-out out 11.1421 Saltbr-out 7.507 HRD-out -96.16, 99.79 -59.97, -43.23 out-in-out SNCoio in-out ActLoopNT-in 3.4008 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 148.15 APE8-dihe-in -53.14, 136.39 APE8-rot-in 259.54 APE67-dihe-in -40.98, -33.42 -92.04, -9.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.2546 T288D None None XRAY 2.75 0.221 0.299 A 279.0 256.0 10 26 16 10 [[133, 383]] 1.0 3m11 CAMK_AURKA_HUMAN CAMK 1.6e-79 272.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4JBPA O14965 126 390 403.0 YPH:501 Type1.5_Front Inactive DFGin 5.8133 16.2215 BLAminus -117.4, 167.72 63.38, 95.52 -104.02, 27.08 282.25, 81.8 -62.06, -18.61 out-out out 10.8244 Saltbr-out 7.1644 HRD-in -70.59, -54.13 72.42, 1.53 out-in-out SNCoio in-out ActLoopNT-in 3.4752 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 161.17 APE8-dihe-in -73.05, 143.32 APE8-rot-out 208.85 APE67-dihe-in -51.16, -32.61 -84.83, -4.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5621 T288D None None XRAY 2.45 0.226 0.291 A 279.0 255.0 10 26 16 10 [[133, 383]] 1.0 4jbp CAMK_AURKA_HUMAN CAMK 1.6e-79 272.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4J8MA O14965 125 390 403.0 CJ5:501 Type1 Inactive DFGin 5.3602 13.8055 BLAplus -146.29, 170.29 51.53, 44.81 -106.0, -2.95 55.0, 80.32 -73.54, 148.11 out-out out 11.7319 Saltbr-out 6.9352 HRD-out -150.5, 159.01 -82.32, 165.77 out-out-out SNCooo out-out ActLoopNT-out 10.6784 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na 70.04, -65.32 APE9-dihe-na 76.22, 9.18 APE8-dihe-out -83.72, -40.53 APE8-rot-in 297.35 APE67-dihe-in -53.15, -21.55 -46.81, -40.82 APE12-dist-out 21.5394 APE11-dist-out 19.6974 APE10-dist-out 14.9139 APE9-dist-out 13.6225 T287D None CAF247 XRAY 1.853 0.178 0.218 A 279.0 266.0 0 26 26 0 [[133, 383]] 1.0 4j8m CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 8PR7D O14965 126 388 403.0 ADP:501 ATPlike Inactive DFGin 6.9163 17.6819 BLBminus -119.47, -172.43 57.55, 67.82 -98.5, 138.77 288.48, 69.88 152.2, -37.73 out-none out 11.7807 Saltbr-none 999.0 HRD-in -89.57, -45.69 63.63, 4.27 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, 178.01 APE9-dihe-na 51.17, 13.86 APE8-dihe-out -88.74, -9.17 APE8-rot-none 999.0 APE67-dihe-in -65.89, -30.04 -136.83, 2.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.9294 APE9-dist-out 11.3958 D274N,C290A,N332A,Q335A,T347A,D350A,C393A None None XRAY 2.76 0.205 0.256 D 283.0 251.0 12 26 14 12 [[133, 383]] 1.0 8pr7 CAMK_AURKA_HUMAN CAMK 3e-77 265.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4C3PA O14965 125 388 403.0 ACP:1389 ATPlike Inactive DFGin 5.1209 15.3112 None -143.16, 44.14 -117.33, -72.7 63.16, 22.36 309.54, 103.5 -71.05, -27.42 out-out out 10.7129 Saltbr-out 4.9547 HRD-out -79.39, 150.41 -121.39, -68.05 out-in-out SNCoio in-out ActLoopNT-in 2.8189 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -49.34, 122.38 APE9-dihe-na 116.03, -35.9 APE8-dihe-out -100.65, -0.54 APE8-rot-out 177.69 APE67-dihe-in -57.5, -32.82 -45.19, -41.29 APE12-dist-out 20.9276 APE11-dist-out 21.1759 APE10-dist-out 26.1561 APE9-dist-out 28.5914 None None None XRAY 2.69 0.205 0.289 A 282.0 264.0 0 26 26 0 [[133, 383]] 1.0 4c3p CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2C6DA O14965 126 390 403.0 ANP:61391 ATPlike Inactive DFGin 6.2574 16.4224 None -70.12, 150.14 -40.51, 101.21 -55.1, 131.85 61.77, 102.87 98.63, -164.78 out-out out 13.1601 Saltbr-out 13.9978 HRD-out -91.98, 166.93 -128.47, 87.17 out-out-out SNCooo out-out ActLoopNT-out 17.9333 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 134.8 APE8-dihe-in -71.63, 167.98 APE8-rot-out 60.54 APE67-dihe-in -57.74, -18.95 -51.64, -36.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.0437 None None None XRAY 2.2 0.23 0.28 A 275.0 255.0 10 26 16 10 [[133, 383]] 1.0 2c6d CAMK_AURKA_HUMAN CAMK 1.5e-79 272.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5ODTA O14965 126 392 403.0 ADP:501 ATPlike Inactive DFGin 6.7171 16.9598 None -121.13, 4.47 -111.78, 32.81 -79.52, 164.76 286.94, 96.78 78.48, -128.28 out-out out 11.7478 Saltbr-out 10.767 HRD-out -137.93, 83.59 -73.55, -34.72 out-out-out SNCooo out-out ActLoopNT-out 17.7885 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, -15.28 APE9-dihe-na -98.55, 177.35 APE8-dihe-out 65.78, -46.63 APE8-rot-none 999.0 APE67-dihe-in -47.55, -29.4 -45.89, -32.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 24.8668 APE9-dist-out 13.4366 D274N,C290A,C393A None None XRAY 2.021 0.179 0.211 A 283.0 258.0 9 26 17 9 [[133, 383]] 1.0 5odt CAMK_AURKA_HUMAN CAMK 5.4e-78 267.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5OBJA O14965 127 390 403.0 ATP:404,9QK:405 ATPlike,Allosteric Inactive DFGin 6.016 15.9671 None -127.31, -156.34 57.9, -96.92 69.6, 25.6 277.68, 99.91 -74.82, -34.09 out-out out 10.8688 Saltbr-out 3.9746 HRD-in -84.35, -43.15 67.43, 1.86 out-in-out SNCoio in-out ActLoopNT-in 2.747 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -85.06 APE9-dihe-na -106.73, -153.17 APE8-dihe-in -86.88, 144.13 APE8-rot-in 279.73 APE67-dihe-in -52.07, -35.29 -66.02, -11.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.3791 APE9-dist-out 10.1992 None None None XRAY 2.901 0.215 0.245 A 272.0 260.0 4 26 22 4 [[133, 383]] 1.0 5obj CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 9GUCA O14965 124 391 403.0 ADP:501,AMP:503 ATPlike,Allosteric Inactive DFGin 7.1772 17.543 None -98.47, -53.8 -99.76, 123.69 -123.57, 999.0 272.41, 116.36 999.0, 999.0 out-none out 10.8811 Saltbr-none 999.0 HRD-in -77.17, -58.19 77.29, 1.39 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na -78.2, -27.21 APE9-dihe-na 141.47, -167.5 APE8-dihe-in -95.93, 123.55 APE8-rot-in 299.51 APE67-dihe-in -57.72, -20.14 -51.84, -47.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.7077 C290A,C393A None None XRAY 2.1 0.193 0.232 A 285.0 256.0 12 26 14 12 [[133, 383]] 1.0 9guc CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 8JF4A O14965 127 389 403.0 C0N:401 Type1 Inactive DFGin 7.2529 17.8729 None -135.45, -161.79 63.9, -97.55 64.54, 6.09 245.37, 117.13 -63.89, -23.61 out-none out 12.6402 Saltbr-none 999.0 HRD-out -120.1, 149.54 -137.31, -168.1 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -130.74 APE9-dihe-na -95.79, -164.69 APE8-dihe-in -61.45, 121.57 APE8-rot-in 284.06 APE67-dihe-in -41.63, -35.05 -74.97, -8.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.8848 APE9-dist-out 12.0317 None None None XRAY 2.893 0.241 0.3 A 263.0 252.0 11 26 15 11 [[133, 383]] 1.0 8jf4 CAMK_AURKA_HUMAN CAMK 5.7e-80 274.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 8JMXA O14965 127 389 403.0 E47:401 Type1 Inactive DFGin 8.1479 17.9382 None -66.97, -135.61 -86.55, 178.72 -114.61, 4.13 278.35, 26.61 128.02, 999.0 out-none out 12.4603 Saltbr-none 999.0 HRD-out -175.92, -143.93 -146.96, -121.49 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, -148.55 APE9-dihe-na -86.45, -174.61 APE8-dihe-out -81.39, -14.34 APE8-rot-out 176.74 APE67-dihe-out -64.27, -11.38 79.63, -40.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.3418 None None None XRAY 2.95 0.231 0.306 A 263.0 250.0 13 26 13 13 [[133, 383]] 1.0 8jmx CAMK_AURKA_HUMAN CAMK 5.7e-80 274.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 7AYIA O14965 125 392 403.0 S9K:501 Type1 Inactive DFGin 5.4193 15.6223 None -144.41, -177.78 68.28, 27.25 -31.37, 999.0 286.89, 77.45 999.0, 999.0 out-out out 11.6263 Saltbr-out 5.2735 HRD-out -134.3, 170.16 -127.02, -53.3 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -25.37 APE8-rot-out 50.94 APE67-dihe-in -37.9, -35.61 -58.22, -27.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.86 0.254 0.297 A 285.0 252.0 16 26 10 16 [[133, 383]] 1.0 7ayi CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2J4ZB O14965 126 395 403.0 626:1395 Type1 Inactive DFGin 4.2178 13.6848 None -135.88, 74.16 -114.29, 33.41 -89.42, 114.89 302.17, 82.01 -8.53, 159.28 out-out out 11.4154 Saltbr-out 7.1624 HRD-out 58.44, 64.77 -95.37, 159.29 out-out-out SNCooo out-out ActLoopNT-out 18.7148 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -94.91, -9.28 APE9-dihe-na 130.48, -157.55 APE8-dihe-in -66.91, 118.34 APE8-rot-in 305.65 APE67-dihe-in -61.18, -13.87 -47.83, -58.47 APE12-dist-out 16.9419 APE11-dist-out 16.0005 APE10-dist-out 16.5324 APE9-dist-out 8.9625 None None None XRAY 2.0 0.214 0.249 B 306.0 270.0 0 26 26 0 [[133, 383]] 1.0 2j4z CAMK_AURKA_HUMAN CAMK 9.9e-80 273.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4O0WA O14965 125 391 403.0 ADN:501 Type1 Inactive DFGin 6.2719 16.5981 None -99.25, -54.63 -80.04, -74.28 72.86, -1.54 279.35, 93.09 -53.76, -20.49 out-out out 11.3192 Saltbr-out 4.9936 HRD-in -77.36, -61.61 76.79, -35.67 out-in-out SNCoio in-out ActLoopNT-in 2.7811 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -96.78, 99.9 APE9-dihe-na 173.74, 169.14 APE8-dihe-in -81.74, 143.07 APE8-rot-out 200.15 APE67-dihe-in -47.45, -41.6 -91.34, -9.3 APE12-dist-none 999.0 APE11-dist-in 12.2482 APE10-dist-out 14.98 APE9-dist-out 11.7548 H254Y None None XRAY 2.6 0.246 0.277 A 282.0 259.0 8 26 18 8 [[133, 383]] 1.0 4o0w CAMK_AURKA_HUMAN CAMK 1.5e-78 269.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3H0ZA O14965 128 388 403.0 45B:1 Type1 Inactive DFGin 7.3472 16.083 None -89.96, 161.55 64.52, -172.92 -163.13, -57.24 280.93, 123.29 171.24, 120.64 out-out out 10.3185 Saltbr-out 7.3796 HRD-out -71.52, 144.0 -92.02, -55.66 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 126.34 APE8-rot-out 164.31 APE67-dihe-in -55.12, -32.9 -104.49, -8.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K124A,T287A,T288A None None XRAY 2.92 0.221 0.286 A 268.0 248.0 13 26 13 13 [[133, 383]] 1.0 3h0z CAMK_AURKA_HUMAN CAMK 3.9e-79 271.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4DHFA O14965 128 389 403.0 0K6:401 Type1 Inactive DFGin 6.0606 15.9561 None -124.92, -165.4 70.7, -102.39 69.61, 140.83 290.26, 89.34 63.95, 95.41 in-in in 8.9889 Saltbr-in 2.893 HRD-in -73.28, -47.83 72.66, -2.67 in-in-out SNCiio in-out ActLoopNT-in 3.5586 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -6.14 APE9-dihe-na -59.01, 54.1 APE8-dihe-out 19.82, 17.91 APE8-rot-out 105.73 APE67-dihe-out -28.21, -43.1 61.5, -49.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.7292 APE9-dist-out 7.9962 T287D,T288D None None XRAY 2.8 0.21 0.299 A 271.0 258.0 4 26 22 4 [[133, 383]] 1.0 4dhf CAMK_AURKA_HUMAN CAMK 1.8e-79 272.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4DHFB O14965 128 389 403.0 0K6:401 Type1 Inactive DFGin 6.2133 16.1482 None -129.3, -166.63 71.78, -102.87 78.31, 163.45 277.6, 93.12 43.8, 85.35 in-in in 9.3755 Saltbr-in 3.1006 HRD-in -78.27, -44.01 67.72, -6.17 in-in-out SNCiio in-out ActLoopNT-in 2.9195 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -62.03 APE9-dihe-na -175.18, -54.66 APE8-dihe-out 61.81, -74.57 APE8-rot-out 81.7 APE67-dihe-out -53.34, -26.37 96.06, -28.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.9693 APE9-dist-out 10.0958 T287D,T288D None None XRAY 2.8 0.21 0.299 B 271.0 258.0 4 26 22 4 [[133, 383]] 1.0 4dhf CAMK_AURKA_HUMAN CAMK 1.8e-79 272.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4PRJA O14965 125 388 403.0 2VU:401 Type1 Inactive DFGin 5.9517 15.2568 None -87.9, -78.85 -67.3, 132.08 -130.02, 25.75 273.54, 81.31 -60.0, -22.81 in-in in 9.9032 Saltbr-in 3.107 HRD-in -70.35, -53.13 72.43, -26.65 in-in-out SNCiio in-out ActLoopNT-in 3.0892 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnoo APE10-dihe-na 999.0, 60.06 APE9-dihe-na -85.89, -100.42 APE8-dihe-in -76.32, 127.81 APE8-rot-out 186.15 APE67-dihe-out -49.54, 145.49 -72.25, -20.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.5199 APE9-dist-out 11.3043 K124A,Q154N,A203S,R251K,T287A,T288A,E336D None None XRAY 2.8 0.233 0.275 A 269.0 251.0 13 26 16 10 [[133, 383]] 1.0 4prj CAMK_AURKA_HUMAN CAMK 6.9e-79 270.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5AAEA O14965 126 388 403.0 7HD:1389 Type1 Inactive DFGin 5.9398 15.1503 None -95.89, -104.86 -82.25, 148.83 -122.78, 23.14 291.0, 74.49 -53.63, -36.45 out-none out 10.8697 Saltbr-none 999.0 HRD-in -83.0, -21.45 60.1, -65.55 none-in-out SNCnio in-out ActLoopNT-in 3.0061 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -177.84 APE8-dihe-in -88.91, 121.07 APE8-rot-out 73.44 APE67-dihe-in -49.15, -25.21 -87.19, -36.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0803 C290A,C393A None None XRAY 3.11 0.241 0.291 A 285.0 252.0 11 26 15 11 [[133, 383]] 1.0 5aae CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4O0UA O14965 126 391 403.0 ADN:501 Type1 Inactive DFGin 6.2642 11.4304 None -100.67, -17.12 -134.58, 129.02 -80.64, -37.58 28.72, 51.86 64.49, -126.4 out-out out 12.2241 Saltbr-out 10.2319 HRD-out -138.46, 154.69 -78.12, -46.1 out-in-out SNCoio in-out ActLoopNT-in 3.5193 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -78.11, -47.49 APE9-dihe-na -96.12, 155.1 APE8-dihe-in -73.36, 140.7 APE8-rot-out 180.88 APE67-dihe-in -47.54, -36.76 -84.86, -11.52 APE12-dist-out 18.1413 APE11-dist-out 15.8917 APE10-dist-out 13.345 APE9-dist-out 11.2984 H254R None None XRAY 2.6 0.236 0.273 A 282.0 259.0 7 26 19 7 [[133, 383]] 1.0 4o0u CAMK_AURKA_HUMAN CAMK 3.5e-78 268.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4UZDA O14965 127 388 403.0 QMN:1389 Type1.5_Front Inactive DFGin 4.7703 14.7373 None -129.81, 37.03 -50.55, -31.01 -53.57, 125.59 325.32, 89.96 118.13, 999.0 out-out out 11.6146 Saltbr-out 8.8418 HRD-out 53.57, 64.67 -94.14, 134.34 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -65.57, -29.93 APE9-dihe-na 142.25, -148.89 APE8-dihe-in -77.46, 105.91 APE8-rot-in 292.33 APE67-dihe-in -60.25, -12.9 -39.34, -60.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.5975 None None None XRAY 3.2 0.215 0.262 A 287.0 254.0 8 26 18 8 [[133, 383]] 1.0 4uzd CAMK_AURKA_HUMAN CAMK 7.9e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4UZDB O14965 125 389 403.0 QMN:1390 Type1.5_Front Inactive DFGin 4.5757 14.7196 None -129.5, 39.33 -48.31, -42.14 -43.39, 138.93 326.34, 95.13 97.81, -168.36 out-out out 11.585 Saltbr-out 9.3972 HRD-out 50.88, 59.12 -92.12, 140.19 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -64.7, -29.88 APE9-dihe-na 143.96, -147.24 APE8-dihe-in -77.35, 106.49 APE8-rot-in 291.41 APE67-dihe-in -62.64, -12.41 -49.18, -49.73 APE12-dist-out 16.5866 APE11-dist-out 15.4049 APE10-dist-out 16.5271 APE9-dist-out 9.5026 None None None XRAY 3.2 0.215 0.262 B 287.0 258.0 7 26 19 7 [[133, 383]] 1.0 4uzd CAMK_AURKA_HUMAN CAMK 7.9e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4UYNA O14965 125 391 403.0 Y3M:1392 Type1.5_Front Inactive DFGin 4.6948 14.0105 None -129.71, 33.27 -11.88, -124.06 104.64, 86.61 36.8, 56.54 29.97, 999.0 out-out out 11.4313 Saltbr-out 9.4418 HRD-out 56.55, 66.12 -91.27, 149.56 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -53.31, -27.51 999.0, -36.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.201 0.234 A 287.0 249.0 18 26 10 16 [[133, 383]] 1.0 4uyn CAMK_AURKA_HUMAN CAMK 1.8e-79 272.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4C3RA O14965 127 388 403.0 ACP:1389 ATPlike Inactive DFGinter 6.0871 8.639 None -114.31, -7.36 -87.64, 130.6 -72.8, -47.16 285.43, 29.08 69.28, 138.63 out-out out 11.9632 Saltbr-out 7.7849 HRD-out -148.79, 112.09 -68.12, -80.01 out-out-out SNCooo out-out ActLoopNT-out 8.0165 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 137.49 APE8-dihe-in -74.84, 138.8 APE8-rot-out 199.32 APE67-dihe-in -50.64, -36.72 -89.13, -8.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.2314 None None None XRAY 2.79 0.229 0.306 A 282.0 252.0 10 26 16 10 [[133, 383]] 1.0 4c3r CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 6C83B O14965 127 388 403.0 ACP:501 ATPlike Inactive DFGinter 7.3169 8.5877 None -129.69, 90.85 -100.04, 101.37 -135.34, 999.0 303.1, 99.49 999.0, 999.0 out-out out 12.1149 Saltbr-out 10.0494 HRD-out -96.09, 116.19 -110.78, 111.97 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -90.23 APE8-dihe-out -77.58, -0.58 APE8-rot-out 85.03 APE67-dihe-in -69.49, -5.14 -61.84, -44.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.4721 None None None XRAY 2.55 0.268 0.322 B 285.0 247.0 15 26 11 15 [[133, 383]] 1.0 6c83 CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5L8JA O14965 126 391 403.0 ADP:60501 ATPlike Inactive DFGinter 6.0388 8.8115 None -121.42, -0.81 -92.81, -3.45 60.99, 19.44 297.14, 26.84 -77.84, 60.22 out-out out 13.2014 Saltbr-out 9.5877 HRD-out -100.39, 154.9 -77.66, -154.82 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 16.48 APE8-rot-out 62.75 APE67-dihe-in -57.65, -20.32 -54.21, -40.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C290A,C393A TPO288 TPO288 XRAY 1.68 0.201 0.231 A 285.0 253.0 13 26 13 13 [[133, 383]] 1.0 5l8j CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5L8KA O14965 126 392 403.0 ADP:60501 ATPlike Inactive DFGinter 5.9336 8.6956 None -123.53, 3.87 -94.88, 4.13 51.12, 25.43 307.6, 8.65 -83.23, 69.32 out-out out 12.9065 Saltbr-out 9.1369 HRD-out -94.24, 154.96 -82.75, -161.39 out-out-out SNCooo out-out ActLoopNT-out 5.2619 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -60.54, 152.13 APE9-dihe-na 121.57, -104.82 APE8-dihe-in -138.45, 120.03 APE8-rot-in 300.38 APE67-dihe-in -56.47, -22.96 -75.46, -21.38 APE12-dist-out 14.1901 APE11-dist-out 17.8848 APE10-dist-out 19.7221 APE9-dist-out 13.7291 C290A,C393A TPO288 TPO288 XRAY 1.79 0.192 0.235 A 285.0 267.0 0 26 26 0 [[133, 383]] 1.0 5l8k CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5L8LA O14965 126 389 403.0 ADP:60501 ATPlike Inactive DFGinter 5.6468 8.8822 None -117.8, 6.57 -92.89, -1.12 53.22, 20.44 289.58, 36.26 -84.0, 68.46 out-out out 12.5405 Saltbr-out 9.0265 HRD-out -99.09, 148.91 -94.35, -164.8 out-out-out SNCooo out-out ActLoopNT-out 5.3927 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -75.26, -165.41 APE9-dihe-na -67.89, -63.26 APE8-dihe-out -124.39, -179.64 APE8-rot-out 64.28 APE67-dihe-in -57.8, -26.84 -83.02, -0.31 APE12-dist-in 11.1091 APE11-dist-out 16.5204 APE10-dist-out 14.4907 APE9-dist-out 14.6386 C290A,C393A TPO288 TPO288 XRAY 1.67 0.193 0.223 A 285.0 264.0 0 26 26 0 [[133, 383]] 1.0 5l8l CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 8PR7A O14965 124 389 403.0 ADP:501 ATPlike Inactive DFGinter 5.0698 10.2727 None -105.95, 148.75 -124.79, 28.7 -129.06, 999.0 303.51, 120.23 999.0, 999.0 out-out out 12.4819 Saltbr-out 11.7057 HRD-out 52.78, 71.6 -97.43, 142.22 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 47.95, -115.05 APE9-dihe-na -125.01, 9.37 APE8-dihe-out -40.29, -50.01 APE8-rot-out 85.86 APE67-dihe-in -55.11, -34.07 -62.49, -38.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.8319 D274N,C290A,N332A,Q335A,T347A,D350A,C393A None None XRAY 2.76 0.205 0.256 A 283.0 253.0 13 26 13 13 [[133, 383]] 1.0 8pr7 CAMK_AURKA_HUMAN CAMK 3e-77 265.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 6XKAA O14965 127 388 403.0 No_ligand No_ligand Inactive DFGinter 8.9294 7.5102 None -127.13, 56.47 -140.31, 176.96 -101.27, 7.78 308.94, 105.52 -69.78, 61.67 out-out out 12.6318 Saltbr-out 9.0191 HRD-out -107.58, 148.94 -95.64, -139.96 out-out-out SNCooo out-out ActLoopNT-out 5.4147 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -48.95 APE8-dihe-out -61.69, -24.7 APE8-rot-in 274.82 APE67-dihe-in -56.0, -24.76 -53.72, -21.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 35.0529 None None None XRAY 2.65 0.226 0.279 A 292.0 252.0 10 26 16 10 [[133, 383]] 1.0 6xka CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2WTVA O14965 125 389 403.0 ZZL:1390 Type1 Inactive DFGinter 5.7006 9.4543 None -75.22, 156.08 -105.21, 156.98 57.55, 45.32 319.02, 110.91 -59.58, -21.68 out-out out 12.2244 Saltbr-out 9.7382 HRD-out 56.62, 39.51 -65.34, 136.35 out-out-out SNCooo out-out ActLoopNT-out 17.312 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -58.52, -47.8 APE9-dihe-na -54.18, -45.12 APE8-dihe-out -70.51, -43.3 APE8-rot-in 297.14 APE67-dihe-in -48.3, -25.92 -57.93, -45.43 APE12-dist-in 8.2869 APE11-dist-in 12.3199 APE10-dist-out 15.0391 APE9-dist-out 12.5887 L215R,T217E,R220K TPO287,TPO288 TPO287,TPO288,CME290 XRAY 2.4 0.167 0.211 A 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 2wtv CAMK_AURKA_HUMAN CAMK 2.7e-81 278.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2WTVB O14965 126 389 403.0 ZZL:1390 Type1 Inactive DFGinter 5.619 9.4225 None -74.68, 158.58 -101.8, 146.26 63.97, 49.3 317.28, 114.07 -55.55, -26.4 out-out out 12.4193 Saltbr-out 10.2967 HRD-out -138.44, 123.91 -119.97, 134.75 out-out-out SNCooo out-out ActLoopNT-out 19.5109 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na 85.02, 1.5 APE9-dihe-na 116.84, -135.44 APE8-dihe-in -82.25, 112.82 APE8-rot-in 306.92 APE67-dihe-in -64.29, -12.84 -49.83, -55.07 APE12-dist-out 14.754 APE11-dist-out 14.7502 APE10-dist-out 12.235 APE9-dist-out 12.2869 L215R,T217E,R220K TPO287,TPO288 TPO287,TPO288,CME290 XRAY 2.4 0.167 0.211 B 285.0 264.0 0 26 26 0 [[133, 383]] 1.0 2wtv CAMK_AURKA_HUMAN CAMK 2.7e-81 278.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2WTVC O14965 126 389 403.0 ZZL:1392 Type1 Inactive DFGinter 5.6558 9.3615 None -73.47, 155.34 -96.85, 146.28 67.08, 43.87 316.19, 116.1 -46.77, -31.93 out-out out 12.3893 Saltbr-out 10.3055 HRD-out -138.88, 125.11 -124.14, 137.81 out-out-out SNCooo out-out ActLoopNT-out 19.519 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na 85.46, 1.21 APE9-dihe-na 119.13, -135.87 APE8-dihe-in -82.97, 108.09 APE8-rot-in 299.33 APE67-dihe-in -62.27, -12.5 -42.96, -58.15 APE12-dist-out 14.7656 APE11-dist-out 14.7278 APE10-dist-out 12.2667 APE9-dist-out 12.403 L215R,T217E,R220K TPO287,TPO288 TPO287,TPO288,CME290 XRAY 2.4 0.167 0.211 C 285.0 264.0 0 26 26 0 [[133, 383]] 1.0 2wtv CAMK_AURKA_HUMAN CAMK 2.7e-81 278.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2WTVD O14965 125 389 403.0 ZZL:1390 Type1 Inactive DFGinter 5.688 9.4465 None -74.49, 159.41 -108.43, 161.13 55.07, 43.29 317.21, 115.65 -58.54, -27.22 out-out out 12.1938 Saltbr-out 9.7964 HRD-out 49.31, 42.91 -68.48, 131.43 out-out-out SNCooo out-out ActLoopNT-out 17.0587 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -57.61, -41.18 APE9-dihe-na -56.01, -51.32 APE8-dihe-out -76.54, -36.16 APE8-rot-out 70.56 APE67-dihe-in -47.19, -33.07 -56.26, -46.95 APE12-dist-in 8.3139 APE11-dist-in 12.4802 APE10-dist-out 15.096 APE9-dist-out 12.4934 L215R,T217E,R220K TPO287,TPO288 TPO287,TPO288,CME290 XRAY 2.4 0.167 0.211 D 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 2wtv CAMK_AURKA_HUMAN CAMK 2.7e-81 278.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5EW9A O14965 127 390 403.0 5VC:1000 Type1 Inactive DFGinter 7.1431 9.1464 None -125.76, 68.03 -116.07, 111.14 -114.04, 30.21 299.83, 98.64 76.42, 31.17 out-out out 12.2084 Saltbr-out 14.928 HRD-out 51.87, 61.64 -81.46, 128.2 out-out-out SNCooo out-out ActLoopNT-out 13.1788 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -81.31, 136.15 APE9-dihe-na 106.85, -151.62 APE8-dihe-in -130.38, 126.41 APE8-rot-in 294.67 APE67-dihe-in -61.4, -16.67 -41.18, -56.68 APE12-dist-in 12.1083 APE11-dist-in 12.3747 APE10-dist-out 8.7535 APE9-dist-out 7.2605 None TPO287,TPO288 TPO287,TPO288 XRAY 2.181 0.191 0.237 A 271.0 259.0 5 26 21 5 [[133, 383]] 1.0 5ew9 CAMK_AURKA_HUMAN CAMK 6.3e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 6C2RA O14965 128 389 403.0 EG7:404 Type1 Inactive DFGinter 9.1622 6.9873 None -129.68, 71.59 -143.19, 175.42 -111.66, 41.6 306.56, 98.21 -112.1, 49.9 out-none out 12.5467 Saltbr-none 999.0 HRD-out -119.24, 148.11 -82.73, -152.25 none-out-out SNCnoo out-out ActLoopNT-out 5.5402 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -49.7 APE8-rot-out 174.63 APE67-dihe-in -50.05, -30.9 -49.27, -45.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.96 0.187 0.228 A 272.0 250.0 12 26 14 12 [[133, 383]] 1.0 6c2r CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 6C2TA O14965 128 388 403.0 EGJ:401 Type1 Inactive DFGinter 5.758 8.6067 None -125.5, 12.46 -90.2, -9.56 59.46, 21.11 281.41, 42.78 -76.77, 51.45 out-out out 12.1381 Saltbr-out 8.2211 HRD-out -119.45, 155.85 -86.58, -149.59 out-out-out SNCooo out-out ActLoopNT-out 5.4123 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -68.15, 136.69 APE9-dihe-na 71.69, 6.8 APE8-dihe-out -94.33, -26.09 APE8-rot-out 197.45 APE67-dihe-in -52.44, -25.84 -48.85, -45.94 APE12-dist-out 23.1217 APE11-dist-out 26.7222 APE10-dist-out 30.388 APE9-dist-out 34.8387 None None None XRAY 1.73 0.185 0.22 A 272.0 253.0 8 26 18 8 [[133, 383]] 1.0 6c2t CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3W16A O14965 126 388 403.0 P9J:501 Type1 Inactive DFGinter 8.4189 7.0708 None -121.69, 15.12 -95.95, 166.06 -111.07, 78.29 312.23, 83.01 -146.87, 73.18 out-out out 12.3431 Saltbr-out 10.3281 HRD-out -113.79, 141.39 -72.7, -138.65 out-out-out SNCooo out-out ActLoopNT-out 5.3951 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 65.19 APE8-dihe-in -37.14, 90.48 APE8-rot-out 235.25 APE67-dihe-out -39.45, -35.35 47.17, -54.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.4937 None None None XRAY 2.8 0.235 0.322 A 278.0 249.0 14 26 15 11 [[133, 383]] 1.0 3w16 CAMK_AURKA_HUMAN CAMK 7e-80 274.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2J50A O14965 128 389 403.0 627:1390 Type1 Inactive DFGinter 9.2461 7.0202 None -113.57, -10.87 -64.28, 174.0 -114.87, 30.19 305.8, 146.38 -88.31, 66.84 out-out out 12.5095 Saltbr-out 9.2938 HRD-out -123.95, 152.65 -81.99, -145.81 out-out-out SNCooo out-out ActLoopNT-out 5.4444 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -105.31, 129.43 APE9-dihe-na 72.62, 27.27 APE8-dihe-out -102.11, -34.98 APE8-rot-in 309.79 APE67-dihe-in -58.95, -17.94 -50.8, -43.26 APE12-dist-out 19.5659 APE11-dist-out 16.6559 APE10-dist-out 20.8024 APE9-dist-out 14.6959 None None None XRAY 3.0 0.221 0.268 A 280.0 250.0 12 26 18 8 [[133, 383]] 1.0 2j50 CAMK_AURKA_HUMAN CAMK 7.2e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2J50B O14965 128 389 403.0 627:1390 Type1 Inactive DFGinter 9.2456 7.02 None -113.53, -10.86 -64.28, 174.02 -114.89, 30.13 305.81, 146.41 -88.25, 66.85 out-out out 12.5096 Saltbr-out 9.2936 HRD-out -123.96, 152.62 -82.01, -145.78 out-out-out SNCooo out-out ActLoopNT-out 5.4447 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -105.31, 129.37 APE9-dihe-na 72.63, 27.29 APE8-dihe-out -102.14, -34.97 APE8-rot-in 309.77 APE67-dihe-in -58.91, -17.97 -50.79, -43.31 APE12-dist-out 19.5656 APE11-dist-out 16.6557 APE10-dist-out 20.8022 APE9-dist-out 14.6957 None None None XRAY 3.0 0.221 0.268 B 280.0 250.0 12 26 18 8 [[133, 383]] 1.0 2j50 CAMK_AURKA_HUMAN CAMK 7.2e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4ZTRA O14965 127 388 403.0 4RJ:501 Type1 Inactive DFGinter 8.9966 8.6737 None -145.71, 65.97 -113.49, 176.73 -135.74, 26.63 211.29, 77.47 -104.42, 142.78 out-out out 13.0732 Saltbr-out 9.5025 HRD-out 62.28, 87.69 -105.24, 141.97 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -99.17 APE8-dihe-in -82.2, 138.42 APE8-rot-out 194.18 APE67-dihe-in -47.8, -30.35 -87.76, -14.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.4904 None None None XRAY 2.85 0.215 0.268 A 285.0 249.0 13 26 13 13 [[133, 383]] 1.0 4ztr CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 6Z4YA O14965 124 389 403.0 Q7Q:508 Type1 Inactive DFGinter 5.7933 8.4854 None -99.87, -29.52 -56.3, 117.27 -64.91, 155.66 280.74, 8.23 -48.06, 135.67 out-out out 12.2611 Saltbr-out 8.7243 HRD-out -130.04, 168.56 -116.49, -65.11 out-out-out SNCooo out-out ActLoopNT-out 8.298 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 118.23 APE9-dihe-na -146.9, 152.55 APE8-dihe-in -65.96, 130.4 APE8-rot-in 311.48 APE67-dihe-in -49.06, -39.99 -82.96, -11.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.1746 APE9-dist-out 11.1005 None None None XRAY 2.25 0.209 0.257 A 285.0 259.0 7 26 19 7 [[133, 383]] 1.0 6z4y CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 6CPGA O14965 127 387 403.0 35R:501 Type1 Inactive DFGinter 6.711 9.4851 None -140.02, 96.03 -108.44, 103.16 -141.15, -67.9 302.74, 112.44 175.19, -125.6 out-out out 12.4294 Saltbr-out 10.9407 HRD-out 55.39, 71.59 -104.21, 123.45 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, -80.02 APE9-dihe-na 97.77, -146.55 APE8-dihe-out -62.97, -12.48 APE8-rot-none 999.0 APE67-dihe-in -58.41, -29.26 -54.85, -41.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.0413 APE9-dist-out 13.6566 None None None XRAY 2.8 0.285 0.335 A 285.0 249.0 12 26 14 12 [[133, 383]] 1.0 6cpg CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 6CPGD O14965 127 388 403.0 35R:501 Type1 Inactive DFGinter 6.4037 9.7723 None -125.89, 77.36 -98.94, 84.58 -127.68, 52.17 302.92, 103.94 97.64, -149.27 out-out out 11.6201 Saltbr-out 12.7753 HRD-out 61.84, 98.64 -116.43, 122.15 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nooo APE10-dihe-na -115.97, 178.85 APE9-dihe-na -115.52, -132.49 APE8-dihe-out -76.59, 1.28 APE8-rot-out 68.27 APE67-dihe-in -65.85, -12.72 -75.15, -27.74 APE12-dist-none 999.0 APE11-dist-out 19.3876 APE10-dist-out 16.4598 APE9-dist-out 14.8298 None None None XRAY 2.8 0.285 0.335 D 285.0 252.0 10 26 16 10 [[133, 383]] 1.0 6cpg CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 8SSOA O14965 127 389 403.0 627:503 Type1 Inactive DFGinter 5.3986 10.215 None -108.08, -33.36 50.1, -154.98 50.19, 34.56 301.31, 89.86 -57.19, -31.19 out-out out 12.3336 Saltbr-out 8.6183 HRD-out 58.03, 59.93 -81.1, 151.47 out-out-out SNCooo out-out ActLoopNT-out 16.6026 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na -77.17, 142.4 APE9-dihe-na -91.52, -9.13 APE8-dihe-out -58.73, -51.63 APE8-rot-in 325.37 APE67-dihe-in -60.47, -22.49 -51.35, -46.12 APE12-dist-none 999.0 APE11-dist-out 14.2442 APE10-dist-out 9.6966 APE9-dist-out 11.7439 None None None XRAY 1.97 0.194 0.234 A 285.0 256.0 7 26 19 7 [[133, 383]] 1.0 8sso CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 8SSOD O14965 127 389 403.0 627:501 Type1 Inactive DFGinter 5.2809 10.1223 None -105.7, -31.6 53.01, -156.16 52.08, 37.65 306.05, 89.37 -57.92, -31.1 out-out out 12.2914 Saltbr-out 8.4761 HRD-out 56.18, 68.26 -87.55, 151.34 out-out-none SNCoon out-none ActLoopNT-out 16.7335 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -51.48 APE8-rot-in 286.23 APE67-dihe-in -64.32, -21.7 -60.98, -32.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.97 0.194 0.234 D 285.0 252.0 11 26 15 11 [[133, 383]] 1.0 8sso CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 1MUOA O14965 128 388 403.0 ADN:1 Type1 Inactive DFGinter 5.924 9.0061 None -137.2, 91.65 -102.67, 104.14 -141.95, -158.0 317.38, 80.93 -72.97, -80.68 out-out out 11.3153 Saltbr-out 7.8585 HRD-out -71.01, -147.46 164.07, -11.44 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na -39.4, -7.29 APE9-dihe-na -9.41, -37.67 APE8-dihe-out -44.74, -65.33 APE8-rot-in 311.2 APE67-dihe-in -15.91, -41.07 -76.59, -51.98 APE12-dist-none 999.0 APE11-dist-out 18.1963 APE10-dist-out 19.8486 APE9-dist-out 11.811 None None None XRAY 2.9 0.26 0.29 A 297.0 251.0 10 26 16 10 [[133, 383]] 1.0 1muo CAMK_AURKA_HUMAN CAMK 8.9e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2J4ZA O14965 126 389 403.0 626:1389 Type1 Inactive DFGinter 6.6272 9.7164 None -134.66, 62.98 -108.04, 40.82 -66.1, -23.24 173.81, 60.57 87.3, -158.48 out-out out 12.4364 Saltbr-out 8.0569 HRD-out 53.27, 78.66 -109.39, 156.45 out-out-out SNCooo out-out ActLoopNT-out 18.6354 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -90.61, -7.12 APE9-dihe-na 129.6, -174.7 APE8-dihe-in -67.83, 122.81 APE8-rot-in 307.59 APE67-dihe-in -55.64, -29.26 -49.16, -49.7 APE12-dist-out 15.5335 APE11-dist-in 13.8401 APE10-dist-out 16.3737 APE9-dist-out 7.6149 None None None XRAY 2.0 0.214 0.249 A 306.0 264.0 0 26 26 0 [[133, 383]] 1.0 2j4z CAMK_AURKA_HUMAN CAMK 9.9e-80 273.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3UNZA O14965 127 389 403.0 0BZ:2 Type1 Inactive DFGinter 5.99 8.9219 None -84.5, -63.75 54.99, -138.14 56.38, -121.0 215.05, 157.51 -49.6, 129.64 out-out out 11.6353 Saltbr-out 8.5069 HRD-out 65.37, 47.67 -71.53, 145.54 out-out-out SNCooo out-out ActLoopNT-out 17.1615 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 99.65, -2.93 APE9-dihe-na -89.71, 20.26 APE8-dihe-out -80.64, -73.77 APE8-rot-out 51.18 APE67-dihe-in -55.59, -35.44 -82.63, -1.22 APE12-dist-out 14.5531 APE11-dist-in 10.8394 APE10-dist-out 15.946 APE9-dist-out 14.0456 T287D None None XRAY 2.8 0.231 0.278 A 279.0 263.0 0 26 26 0 [[133, 383]] 1.0 3unz CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3UNZB O14965 127 389 403.0 0BZ:1 Type1 Inactive DFGinter 5.9852 8.919 None -84.43, -63.71 55.14, -138.06 56.46, -120.92 215.0, 157.19 -49.66, 129.46 out-out out 11.6396 Saltbr-out 8.5001 HRD-out 65.25, 47.84 -72.14, 146.01 out-out-out SNCooo out-out ActLoopNT-out 17.1541 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 99.26, -2.89 APE9-dihe-na -90.04, 20.41 APE8-dihe-out -81.04, -73.69 APE8-rot-out 50.59 APE67-dihe-in -55.45, -35.38 -82.74, -1.38 APE12-dist-out 14.5607 APE11-dist-in 10.842 APE10-dist-out 15.9499 APE9-dist-out 14.036 T287D None None XRAY 2.8 0.231 0.278 B 279.0 263.0 0 26 26 0 [[133, 383]] 1.0 3unz CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3UO6A O14965 126 389 403.0 0BY:1 Type1 Inactive DFGinter 6.0888 8.9465 None -92.08, -63.22 55.79, -136.4 58.35, -117.73 204.46, 160.17 -58.84, 166.86 out-out out 11.3025 Saltbr-out 11.4219 HRD-out 44.35, 72.76 -98.46, 135.56 out-out-out SNCooo out-out ActLoopNT-out 17.2272 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 76.96, -17.98 APE9-dihe-na -113.29, 10.31 APE8-dihe-out -74.35, -72.68 APE8-rot-out 36.75 APE67-dihe-in -49.94, -38.95 -75.25, -15.59 APE12-dist-out 14.6421 APE11-dist-in 12.2047 APE10-dist-out 16.5919 APE9-dist-out 14.1631 T287D None None XRAY 2.8 0.229 0.276 A 279.0 264.0 0 26 26 0 [[133, 383]] 1.0 3uo6 CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3UO6B O14965 126 389 403.0 0BY:2 Type1 Inactive DFGinter 6.0878 8.9354 None -92.34, -63.27 55.7, -136.72 58.91, -118.35 204.74, 161.14 -58.96, 166.79 out-out out 11.2723 Saltbr-out 11.476 HRD-out 44.24, 73.02 -98.37, 136.49 out-out-out SNCooo out-out ActLoopNT-out 17.2321 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 75.5, -18.28 APE9-dihe-na -114.49, 10.92 APE8-dihe-out -74.12, -73.35 APE8-rot-out 38.72 APE67-dihe-in -50.19, -38.98 -73.97, -15.63 APE12-dist-out 14.6515 APE11-dist-in 12.2094 APE10-dist-out 16.5925 APE9-dist-out 14.1537 T287D None None XRAY 2.8 0.229 0.276 B 279.0 264.0 0 26 26 0 [[133, 383]] 1.0 3uo6 CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3UOHA O14965 126 389 403.0 0C4:2 Type1 Inactive DFGinter 6.0378 8.9143 None -93.18, -63.37 54.89, -130.23 58.47, -116.07 202.5, 1.54 -59.86, 169.88 out-out out 12.2033 Saltbr-out 10.6415 HRD-out 60.57, 51.18 -70.61, 154.26 out-out-out SNCooo out-out ActLoopNT-out 17.2971 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 97.37, -1.48 APE9-dihe-na -94.0, 16.64 APE8-dihe-out -73.09, -72.62 APE8-rot-out 34.55 APE67-dihe-in -54.13, -35.68 -91.14, -1.84 APE12-dist-out 14.3491 APE11-dist-in 11.496 APE10-dist-out 16.5595 APE9-dist-out 14.0026 T287D None None XRAY 2.8 0.23 0.288 A 279.0 264.0 0 26 26 0 [[133, 383]] 1.0 3uoh CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3UOHB O14965 126 389 403.0 0C4:1 Type1 Inactive DFGinter 6.0345 8.9001 None -93.16, -63.34 54.68, -130.86 58.94, -116.29 202.73, 0.89 -60.04, 170.49 out-out out 12.2519 Saltbr-out 10.4593 HRD-out 56.43, 52.93 -71.71, 154.95 out-out-out SNCooo out-out ActLoopNT-out 17.2863 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 97.52, -1.59 APE9-dihe-na -93.94, 16.64 APE8-dihe-out -72.82, -72.33 APE8-rot-out 34.94 APE67-dihe-in -54.2, -36.03 -91.21, -1.67 APE12-dist-out 14.3532 APE11-dist-in 11.5068 APE10-dist-out 16.5755 APE9-dist-out 14.0104 T287D None None XRAY 2.8 0.23 0.288 B 279.0 264.0 0 26 26 0 [[133, 383]] 1.0 3uoh CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3UOJA O14965 127 389 403.0 0C5:1 Type1 Inactive DFGinter 6.2496 8.6517 None -89.03, -64.22 49.6, -140.48 55.65, -113.8 181.43, 6.66 -48.52, 138.84 out-out out 12.9006 Saltbr-out 10.1671 HRD-out 77.34, -11.89 -40.57, 125.77 out-out-out SNCooo out-out ActLoopNT-out 16.7655 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 98.97, 1.26 APE9-dihe-na -102.25, -2.44 APE8-dihe-out -61.85, -58.87 APE8-rot-out 33.31 APE67-dihe-in -56.59, -30.78 -67.25, -33.49 APE12-dist-out 15.3881 APE11-dist-in 12.5887 APE10-dist-out 17.4172 APE9-dist-out 14.292 T287D None None XRAY 2.9 0.227 0.274 A 279.0 263.0 0 26 26 0 [[133, 383]] 1.0 3uoj CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3UOJB O14965 127 389 403.0 0C5:2 Type1 Inactive DFGinter 6.2636 8.6447 None -88.87, -64.57 49.7, -140.5 55.59, -113.73 181.06, 6.55 -48.5, 138.54 out-out out 12.9094 Saltbr-out 10.1475 HRD-out 77.24, -11.84 -40.35, 125.95 out-out-out SNCooo out-out ActLoopNT-out 16.7603 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 98.86, 1.29 APE9-dihe-na -101.95, -2.75 APE8-dihe-out -62.17, -58.93 APE8-rot-out 33.01 APE67-dihe-in -57.8, -30.14 -66.39, -33.04 APE12-dist-out 15.3867 APE11-dist-in 12.5858 APE10-dist-out 17.4158 APE9-dist-out 14.2887 T287D None None XRAY 2.9 0.227 0.274 B 279.0 263.0 0 26 26 0 [[133, 383]] 1.0 3uoj CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3UOKA O14965 125 389 403.0 0C6:2 Type1 Inactive DFGinter 5.7502 9.2837 None -87.48, -71.36 58.97, -135.37 54.65, -117.02 195.51, 34.07 -55.93, 122.72 out-out out 11.8975 Saltbr-out 12.9164 HRD-out 40.64, 72.07 -97.16, 132.51 out-out-out SNCooo out-out ActLoopNT-out 17.0984 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 75.79, -21.51 APE9-dihe-na -114.86, 8.46 APE8-dihe-out -81.91, -68.59 APE8-rot-out 58.99 APE67-dihe-in -48.81, -38.43 -66.52, -22.51 APE12-dist-out 14.1012 APE11-dist-in 12.2923 APE10-dist-out 16.9657 APE9-dist-out 14.8589 T287D None None XRAY 2.951 0.223 0.276 A 279.0 265.0 0 26 26 0 [[133, 383]] 1.0 3uok CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3UOKB O14965 125 389 403.0 0C6:1 Type1 Inactive DFGinter 5.7492 9.2769 None -88.85, -71.53 59.08, -134.89 54.38, -116.99 195.48, 34.01 -56.06, 122.86 out-out out 11.8774 Saltbr-out 12.919 HRD-out 40.28, 71.92 -97.4, 131.84 out-out-out SNCooo out-out ActLoopNT-out 17.0785 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 75.7, -21.55 APE9-dihe-na -114.97, 8.84 APE8-dihe-out -82.0, -69.27 APE8-rot-out 58.99 APE67-dihe-in -49.23, -38.63 -66.58, -21.59 APE12-dist-out 14.0964 APE11-dist-in 12.283 APE10-dist-out 16.9628 APE9-dist-out 14.861 T287D None None XRAY 2.951 0.223 0.276 B 279.0 265.0 0 26 26 0 [[133, 383]] 1.0 3uok CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3UOLA O14965 127 389 403.0 0C7:2 Type1 Inactive DFGinter 6.0688 8.6574 None -80.65, -49.91 38.66, -132.1 60.59, -110.72 197.86, 22.76 -76.74, 23.35 out-out out 13.7802 Saltbr-out 9.949 HRD-out 53.65, 45.58 -63.49, 138.74 out-out-out SNCooo out-out ActLoopNT-out 17.0956 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 91.11, -3.8 APE9-dihe-na -96.74, -20.87 APE8-dihe-out -56.71, -68.79 APE8-rot-out 61.79 APE67-dihe-in -54.04, -24.57 -47.13, -38.35 APE12-dist-out 15.1122 APE11-dist-in 13.7844 APE10-dist-out 17.7242 APE9-dist-out 14.4029 T287D None None XRAY 2.4 0.237 0.283 A 279.0 263.0 0 26 26 0 [[133, 383]] 1.0 3uol CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3UOLB O14965 127 389 403.0 0C7:1 Type1 Inactive DFGinter 5.9903 8.6597 None -80.74, -49.45 38.08, -131.75 60.44, -110.58 198.19, 22.88 -77.08, 23.2 out-out out 13.7763 Saltbr-out 9.9593 HRD-out 54.22, 44.36 -62.05, 139.57 out-out-out SNCooo out-out ActLoopNT-out 17.0935 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 91.25, -3.95 APE9-dihe-na -95.92, -22.22 APE8-dihe-out -56.1, -68.18 APE8-rot-out 62.15 APE67-dihe-in -54.2, -24.78 -47.47, -38.07 APE12-dist-out 15.1229 APE11-dist-in 13.7913 APE10-dist-out 17.7315 APE9-dist-out 14.3906 T287D None None XRAY 2.4 0.237 0.283 B 279.0 263.0 0 26 26 0 [[133, 383]] 1.0 3uol CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3FDNA O14965 126 394 403.0 MMH:1 Type1 Inactive DFGinter 5.8355 8.6997 None -113.83, -12.3 -83.93, 150.0 -89.96, 27.39 288.28, 8.62 -77.57, 62.14 out-out out 12.1684 Saltbr-out 8.3471 HRD-out -96.45, 141.44 -71.53, -154.43 out-out-out SNCooo out-out ActLoopNT-out 5.673 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -102.73 APE9-dihe-na 114.27, 146.94 APE8-dihe-in -67.7, 139.44 APE8-rot-in 273.96 APE67-dihe-in -48.36, -34.0 -88.05, -6.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.5747 APE9-dist-out 13.3401 T288D None None XRAY 1.9 0.231 0.287 A 279.0 261.0 8 26 18 8 [[133, 383]] 1.0 3fdn CAMK_AURKA_HUMAN CAMK 1.6e-79 272.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3K5UA O14965 126 394 403.0 PFQ:1001 Type1 Inactive DFGinter 5.7075 8.8247 None -107.52, -18.97 -91.45, 151.1 -94.09, 23.54 298.73, 177.78 -72.02, 54.86 out-out out 12.1242 Saltbr-out 8.7194 HRD-out -88.39, 148.19 -76.48, -155.88 out-out-out SNCooo out-out ActLoopNT-out 5.3654 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -121.1 APE9-dihe-na 103.03, 152.44 APE8-dihe-in -66.2, 143.09 APE8-rot-in 275.11 APE67-dihe-in -49.38, -31.53 -92.54, -7.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.4606 APE9-dist-out 13.4355 T288D None None XRAY 2.35 0.242 0.26 A 279.0 260.0 9 26 17 9 [[133, 383]] 1.0 3k5u CAMK_AURKA_HUMAN CAMK 1.6e-79 272.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4JBQA O14965 126 391 403.0 VX6:501 Type1 Inactive DFGinter 5.8629 8.9774 None -117.17, -3.86 -81.51, -172.59 -125.34, 20.35 277.47, 29.16 -74.78, 56.29 out-out out 12.3249 Saltbr-out 9.4595 HRD-out -106.24, 150.32 -82.52, -162.88 out-out-out SNCooo out-out ActLoopNT-out 5.4198 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 124.19 APE9-dihe-na 110.15, 136.99 APE8-dihe-in -65.42, 141.32 APE8-rot-out 182.94 APE67-dihe-in -48.15, -34.26 -90.56, -13.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.7182 APE9-dist-out 13.3126 T288D None None XRAY 2.3 0.227 0.282 A 279.0 257.0 9 26 17 9 [[133, 383]] 1.0 4jbq CAMK_AURKA_HUMAN CAMK 1.6e-79 272.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3LAUA O14965 125 391 403.0 OFI:60001 Type1 Inactive DFGinter 4.8739 9.4699 None -122.68, 72.55 -135.5, 105.71 -124.13, 999.0 233.96, 104.58 999.0, 999.0 out-out out 11.6122 Saltbr-out 10.8505 HRD-out 60.88, 64.76 -92.19, 140.49 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.81, -17.37 999.0, -42.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T288D None None XRAY 2.1 0.203 0.248 A 287.0 250.0 17 26 9 17 [[133, 383]] 1.0 3lau CAMK_AURKA_HUMAN CAMK 1.8e-79 272.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4UZHA O14965 125 392 403.0 JVE:61392 Type1 Inactive DFGinter 6.1645 8.8467 None -134.4, 63.5 -102.61, 61.53 -163.5, 999.0 153.81, 66.79 999.0, 999.0 out-out out 11.6163 Saltbr-out 7.1967 HRD-out 56.64, 70.94 -95.92, 131.49 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.98, -11.66 999.0, -76.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.205 0.235 A 287.0 251.0 17 26 9 17 [[133, 383]] 1.0 4uzh CAMK_AURKA_HUMAN CAMK 1.8e-79 272.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3H0YA O14965 126 388 403.0 48B:1 Type1 Inactive DFGinter 6.252 8.4177 None -109.47, -26.38 -75.33, 137.27 -77.12, 162.45 293.82, 171.84 -85.27, 155.38 out-out out 11.7561 Saltbr-out 8.4071 HRD-out -128.83, 133.48 -56.66, -46.86 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 129.6 APE8-rot-out 181.19 APE67-dihe-in -47.87, -33.3 -84.26, -9.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K124A,T287A,T288A None None XRAY 2.5 0.216 0.285 A 268.0 250.0 13 26 13 13 [[133, 383]] 1.0 3h0y CAMK_AURKA_HUMAN CAMK 3.9e-79 271.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3H10A O14965 124 391 403.0 97B:1 Type1 Inactive DFGinter 5.9492 9.2917 None -85.74, 156.36 -96.9, 153.5 66.79, 45.29 317.78, 104.47 -57.91, -32.92 out-out out 11.6847 Saltbr-out 10.3175 HRD-out 59.2, 41.52 -65.77, 140.34 out-out-out SNCooo out-out ActLoopNT-out 17.4337 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -128.56, 51.89 APE9-dihe-na 117.04, -170.29 APE8-dihe-in -90.19, 120.52 APE8-rot-in 294.83 APE67-dihe-in -57.04, -32.9 -46.43, -51.7 APE12-dist-in 10.2759 APE11-dist-out 14.6013 APE10-dist-out 13.5368 APE9-dist-out 10.4758 K124A,T287A,T288A None None XRAY 2.2 0.197 0.24 A 268.0 268.0 0 26 26 0 [[133, 383]] 1.0 3h10 CAMK_AURKA_HUMAN CAMK 3.9e-79 271.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3H10B O14965 125 391 403.0 97B:2 Type1 Inactive DFGinter 6.0858 9.0997 None -84.1, 155.64 -96.32, 147.85 67.68, 47.0 313.1, 101.31 -64.96, -29.8 out-out out 11.3478 Saltbr-out 9.7368 HRD-out 52.62, 55.73 -75.29, 145.84 out-out-out SNCooo out-out ActLoopNT-out 17.5945 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -164.73, 70.51 APE9-dihe-na 110.59, 173.85 APE8-dihe-in -85.08, 117.86 APE8-rot-in 292.57 APE67-dihe-in -65.77, -24.94 -40.25, -55.5 APE12-dist-in 10.3774 APE11-dist-out 14.4906 APE10-dist-out 13.0909 APE9-dist-out 10.6735 K124A,T287A,T288A None None XRAY 2.2 0.197 0.24 B 268.0 267.0 0 26 26 0 [[133, 383]] 1.0 3h10 CAMK_AURKA_HUMAN CAMK 3.9e-79 271.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3H10D O14965 126 388 403.0 97B:3 Type1 Inactive DFGinter 5.6519 9.3506 None -78.35, 156.2 -102.03, 146.36 61.53, 46.31 320.5, 110.27 -53.35, -35.87 out-out out 12.2711 Saltbr-out 10.4052 HRD-out 47.1, 36.06 -65.28, 120.88 out-out-none SNCoon out-none ActLoopNT-out 16.9329 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 130.75 APE8-rot-in 285.65 APE67-dihe-in -49.42, -30.99 -50.38, -44.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K124A,T287A,T288A None None XRAY 2.2 0.197 0.24 D 268.0 255.0 8 26 18 8 [[133, 383]] 1.0 3h10 CAMK_AURKA_HUMAN CAMK 3.9e-79 271.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3P9JA O14965 126 388 403.0 P9J:1 Type1 Inactive DFGinter 6.8837 7.9415 None -102.4, -6.03 -81.85, 156.26 -90.38, 17.14 289.53, 9.94 -77.54, 34.79 out-out out 12.3724 Saltbr-out 9.8794 HRD-out -106.04, 150.63 -81.01, -161.23 out-out-out SNCooo out-out ActLoopNT-out 5.3497 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 98.73 APE8-dihe-in -129.65, 90.21 APE8-rot-out 170.24 APE67-dihe-in -44.1, -38.87 -140.2, 19.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.1027 T287A,T288A None None XRAY 2.8 0.204 0.271 A 268.0 249.0 14 26 15 11 [[133, 383]] 1.0 3p9j CAMK_AURKA_HUMAN CAMK 3.9e-79 271.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3W10A O14965 126 388 403.0 RO9:501 Type1 Inactive DFGinter 6.3733 9.6946 None -119.04, 54.38 -98.61, 30.05 -138.73, 164.74 58.12, 85.11 47.87, 16.56 out-out out 11.8006 Saltbr-out 10.3331 HRD-out 62.97, 65.74 -95.42, 130.99 out-out-out SNCooo out-out ActLoopNT-out 17.4801 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -81.52, 14.87 APE9-dihe-na -42.97, -40.22 APE8-dihe-out -121.83, 17.25 APE8-rot-out 76.19 APE67-dihe-in -68.64, -18.29 -61.37, -40.89 APE12-dist-in 9.7517 APE11-dist-out 14.7144 APE10-dist-out 16.0551 APE9-dist-out 11.7746 T287A,T288A None None XRAY 2.7 0.249 0.309 A 278.0 263.0 0 26 26 0 [[133, 383]] 1.0 3w10 CAMK_AURKA_HUMAN CAMK 4.4e-79 271.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3R22A O14965 126 389 403.0 D37:1 Type1 Inactive DFGinter 6.4723 8.5569 None -142.77, -34.51 -91.78, -141.21 -154.74, 60.2 276.78, 88.9 -152.2, 21.14 out-out out 11.924 Saltbr-out 7.8942 HRD-out -77.07, 147.44 -101.45, -61.81 out-out-out SNCooo out-out ActLoopNT-out 4.7862 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 163.54 APE8-dihe-in -57.16, 146.3 APE8-rot-out 184.12 APE67-dihe-in -47.8, -31.62 -95.89, 1.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.996 T287D,T288D None None XRAY 2.9 0.271 0.313 A 271.0 255.0 9 26 17 9 [[133, 383]] 1.0 3r22 CAMK_AURKA_HUMAN CAMK 1.8e-79 272.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 9KDSA O14965 126 391 403.0 A1EFT:220 Type1 Inactive DFGinter 5.8406 9.0606 None -115.36, -22.96 -73.25, 150.65 -96.11, 14.3 285.47, 2.42 -64.22, 74.88 out-out out 12.2623 Saltbr-out 9.1038 HRD-out -98.78, 149.89 -79.07, -155.21 out-out-out SNCooo out-out ActLoopNT-out 5.2001 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -139.65 APE8-dihe-in -67.03, 136.06 APE8-rot-in 265.66 APE67-dihe-in -47.15, -28.7 -90.01, -5.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.6429 C290A None A1EFT220 XRAY 2.5 0.217 0.253 A 266.0 257.0 9 26 17 9 [[133, 383]] 1.0 9kds CAMK_AURKA_HUMAN CAMK 1e-78 270.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2BMCA O14965 127 394 403.0 MPY:1395 Type1 Inactive DFGinter 6.5807 8.6492 None -120.22, 2.69 -79.74, 177.87 -120.44, 28.65 279.36, 74.44 -63.39, 54.99 out-out out 12.7119 Saltbr-out 9.6481 HRD-out -124.67, 146.35 -86.18, -146.55 out-out-out SNCooo out-out ActLoopNT-out 5.3993 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -132.56 APE8-rot-out 47.16 APE67-dihe-in -49.36, -30.39 -47.35, -35.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.228 0.252 A 306.0 256.0 12 26 14 12 [[133, 383]] 1.0 2bmc CAMK_AURKA_HUMAN CAMK 2.8e-79 272.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2BMCB O14965 125 394 403.0 MPY:1395 Type1 Inactive DFGinter 6.807 8.5295 None -121.32, 0.27 -78.21, 179.92 -122.08, 26.9 281.74, 72.08 -64.82, 57.86 out-out out 12.7424 Saltbr-out 9.3491 HRD-out -129.07, 147.12 -89.63, -143.13 out-out-out SNCooo out-out ActLoopNT-out 5.3349 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -148.66 APE8-rot-out 47.86 APE67-dihe-in -45.98, -40.8 -48.24, -32.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.228 0.252 B 306.0 258.0 12 26 14 12 [[133, 383]] 1.0 2bmc CAMK_AURKA_HUMAN CAMK 2.8e-79 272.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2BMCC O14965 125 393 403.0 MPY:1394 Type1 Inactive DFGinter 6.84 8.5631 None -111.71, -8.17 -78.0, 176.81 -119.82, 27.04 283.62, 65.51 -62.65, 57.16 out-out out 12.7588 Saltbr-out 9.2905 HRD-out -129.54, 151.84 -86.76, -144.72 out-out-out SNCooo out-out ActLoopNT-out 5.4531 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -175.11 APE8-rot-out 45.5 APE67-dihe-in -27.05, -38.79 -54.18, -36.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.228 0.252 C 306.0 257.0 12 26 14 12 [[133, 383]] 1.0 2bmc CAMK_AURKA_HUMAN CAMK 2.8e-79 272.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2BMCD O14965 127 394 403.0 MPY:1395 Type1 Inactive DFGinter 6.7974 8.666 None -115.73, -0.95 -79.88, 179.36 -120.07, 22.55 284.5, 74.5 -63.99, 59.56 out-out out 12.6807 Saltbr-out 9.214 HRD-out -128.93, 150.36 -86.55, -146.18 out-out-out SNCooo out-out ActLoopNT-out 5.4478 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -170.43 APE8-rot-out 54.46 APE67-dihe-in -29.4, -31.11 -37.9, -57.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.228 0.252 D 306.0 256.0 12 26 14 12 [[133, 383]] 1.0 2bmc CAMK_AURKA_HUMAN CAMK 2.8e-79 272.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2BMCE O14965 127 394 403.0 MPY:1395 Type1 Inactive DFGinter 6.8258 8.4887 None -115.38, -3.61 -77.32, 179.54 -120.22, 21.67 284.65, 76.22 -63.51, 61.05 out-out out 12.6416 Saltbr-out 9.4342 HRD-out -126.37, 151.8 -84.41, -148.69 out-out-out SNCooo out-out ActLoopNT-out 5.4524 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -151.66 APE8-rot-out 63.51 APE67-dihe-in -26.62, -34.28 -40.09, -60.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.228 0.252 E 306.0 256.0 12 26 14 12 [[133, 383]] 1.0 2bmc CAMK_AURKA_HUMAN CAMK 2.8e-79 272.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2BMCF O14965 126 394 403.0 MPY:1395 Type1 Inactive DFGinter 6.5085 8.8222 None -115.69, -5.93 -78.56, 177.32 -122.14, 28.38 282.23, 67.06 -65.82, 60.75 out-out out 12.7531 Saltbr-out 9.2711 HRD-out -127.86, 148.46 -84.63, -148.84 out-out-out SNCooo out-out ActLoopNT-out 5.4126 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -159.21 APE8-rot-out 48.76 APE67-dihe-in -12.19, -42.56 -50.87, -58.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.228 0.252 F 306.0 257.0 12 26 14 12 [[133, 383]] 1.0 2bmc CAMK_AURKA_HUMAN CAMK 2.8e-79 272.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 7FICA O14965 127 391 403.0 5YZ:401 Type1 Inactive DFGinter 6.6562 8.6983 None -127.87, 74.52 -84.56, 58.76 -143.59, 98.4 223.5, 108.01 121.48, 144.52 out-none out 11.4309 Saltbr-none 999.0 HRD-out -142.2, 146.4 -144.31, 136.82 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 142.56 APE9-dihe-na -122.69, 31.13 APE8-dihe-out -54.83, -47.63 APE8-rot-out 52.3 APE67-dihe-in -64.7, -30.85 -67.62, -21.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.1675 APE9-dist-out 15.1036 C290A None None XRAY 2.32 0.237 0.274 A 265.0 254.0 11 26 15 11 [[133, 383]] 1.0 7fic CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 9BZGA O14965 127 388 403.0 OG0:501 Type1 Inactive DFGinter 5.5742 8.9545 None -138.21, 40.41 -80.38, -6.22 -58.44, 128.99 169.82, 66.7 87.71, 11.81 out-out out 12.011 Saltbr-out 11.35 HRD-out 57.43, 61.28 -82.68, 137.68 out-out-out SNCooo out-out ActLoopNT-out 16.9054 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -68.5, -47.56 APE9-dihe-na -63.47, -40.24 APE8-dihe-out -67.43, -41.81 APE8-rot-in 291.8 APE67-dihe-in -55.03, -25.33 -61.13, -40.77 APE12-dist-in 8.031 APE11-dist-in 12.1759 APE10-dist-out 14.8132 APE9-dist-out 11.6538 C290A,C393S TPO288 TPO288 XRAY 1.8 0.188 0.22 A 285.0 262.0 0 26 26 0 [[133, 383]] 1.0 9bzg CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 9BZLB O14965 127 388 403.0 OGR:501 Type1 Inactive DFGinter 5.6518 8.9243 None -136.55, 35.09 -77.99, -4.99 -64.56, 136.29 165.56, 68.13 84.66, 11.21 out-out out 12.1448 Saltbr-out 11.5085 HRD-out 58.91, 63.34 -81.19, 137.19 out-out-out SNCooo out-out ActLoopNT-out 16.8417 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -64.8, -45.23 APE9-dihe-na -65.62, -37.14 APE8-dihe-out -65.61, -42.19 APE8-rot-in 287.26 APE67-dihe-in -56.13, -23.23 -60.59, -40.07 APE12-dist-in 8.118 APE11-dist-in 11.6758 APE10-dist-out 14.6215 APE9-dist-out 11.7014 C290A,C393S TPO288 TPO288 XRAY 1.81 0.192 0.214 B 285.0 262.0 0 26 26 0 [[133, 383]] 1.0 9bzl CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 9KS6A O14965 127 391 403.0 A1EG1:162 Type1 Inactive DFGinter 5.888 9.1061 None -147.81, 30.43 -100.08, -15.16 61.73, 18.3 290.83, 10.75 -77.9, 72.48 out-na out 12.4716 Saltbr-na 9.13 HRD-out -111.85, 134.04 -63.11, -66.03 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 127.23 APE8-rot-in 299.78 APE67-dihe-in -48.85, -29.53 -94.69, -1.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None A1EG1162 XRAY 2.75 0.232 0.267 A 265.0 251.0 14 26 12 14 [[133, 383]] 1.0 9ks6 CAMK_AURKA_HUMAN CAMK 2.5e-78 268.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4ZTQA O14965 127 388 403.0 4RM:501 Type1.5_Back Inactive DFGinter 9.794 7.5502 None -128.95, 86.44 -158.65, -177.96 -107.17, 35.48 297.86, 94.26 -105.4, 22.98 out-out out 11.7775 Saltbr-out 13.1482 HRD-out -111.76, 156.87 -90.96, -144.93 out-out-out SNCooo out-out ActLoopNT-out 5.2656 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -178.64 APE8-dihe-in -81.15, 143.47 APE8-rot-out 185.07 APE67-dihe-in -33.25, -44.07 -77.96, -26.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.9414 None None None XRAY 2.8 0.203 0.246 A 285.0 247.0 15 26 15 11 [[133, 383]] 1.0 4ztq CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4ZTSA O14965 127 388 403.0 4RK:501 Type1.5_Back Inactive DFGinter 9.8568 7.6116 None -142.98, 93.02 -162.47, -179.72 -105.27, 64.86 290.53, 116.01 159.83, 107.65 out-out out 12.2378 Saltbr-out 12.5393 HRD-out -124.72, 145.07 -84.3, -151.71 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 133.6 APE8-rot-out 180.3 APE67-dihe-in -43.16, -25.38 -86.65, -10.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.213 0.249 A 285.0 249.0 13 26 13 13 [[133, 383]] 1.0 4zts CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3EFWA O14965 126 388 403.0 AK8:404 Type1.5_Front Inactive DFGinter 6.1659 9.1924 None -114.69, 29.1 -93.31, 98.64 -72.68, 999.0 277.06, 45.29 999.0, 999.0 out-none out 12.5044 Saltbr-none 999.0 HRD-out -100.96, 129.93 -74.44, -133.77 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -49.97, -16.9 999.0, -48.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.29 0.26 0.295 A 267.0 240.0 23 26 9 17 [[133, 383]] 1.0 3efw CAMK_AURKA_HUMAN CAMK 6e-80 274.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3EFWB O14965 126 389 403.0 AK8:404 Type1.5_Front Inactive DFGinter 6.8431 8.7182 None -97.71, -18.22 -58.8, 127.67 -71.64, 999.0 297.41, 150.5 999.0, 999.0 out-out out 12.831 Saltbr-out 9.7516 HRD-out -122.37, 142.08 -72.73, -61.12 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -56.59, -24.0 999.0, -41.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.29 0.26 0.295 B 267.0 242.0 22 26 9 17 [[133, 383]] 1.0 3efw CAMK_AURKA_HUMAN CAMK 6e-80 274.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3O50A O14965 126 388 403.0 LJE:1 Type1.5_Front Inactive DFGinter 6.9257 8.5897 None -120.45, 57.47 -126.6, 83.94 -51.28, 45.89 305.79, 65.53 -47.9, 167.61 out-out out 12.7711 Saltbr-out 9.6877 HRD-out -105.95, -54.24 71.67, 50.89 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.18 APE8-rot-out 177.59 APE67-dihe-in -53.46, -33.48 -54.98, -22.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.285 0.351 A 267.0 246.0 17 26 12 14 [[133, 383]] 1.0 3o50 CAMK_AURKA_HUMAN CAMK 6e-80 274.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3O50B O14965 126 389 403.0 LJE:1 Type1.5_Front Inactive DFGinter 7.1294 8.8014 None -108.79, 36.5 -105.08, 99.13 -72.4, 999.0 308.79, 175.58 999.0, 999.0 out-out out 12.8682 Saltbr-out 9.6362 HRD-out -123.96, 166.98 -117.96, 27.18 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -123.8, 136.42 APE9-dihe-na -70.48, -112.85 APE8-dihe-in -82.24, 115.2 APE8-rot-out 163.63 APE67-dihe-in -35.05, -31.99 -65.91, -24.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.3267 None None None XRAY 2.0 0.285 0.351 B 267.0 249.0 15 26 15 11 [[133, 383]] 1.0 3o50 CAMK_AURKA_HUMAN CAMK 6e-80 274.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 6HJJA O14965 127 393 403.0 G7T:501 Type1.5_Front Inactive DFGinter 6.251 8.4927 None -112.85, -19.21 -86.09, 145.25 -81.54, -160.25 301.92, 166.71 41.76, 103.89 out-out out 12.3082 Saltbr-out 9.3111 HRD-out -108.67, 152.78 -84.21, -142.85 out-out-out SNCooo out-out ActLoopNT-out 5.7023 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.9 APE8-dihe-in -60.46, 140.32 APE8-rot-out 182.81 APE67-dihe-in -42.69, -33.03 -85.17, -13.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.2199 L210C,C290A,C393A None None XRAY 2.13 0.212 0.269 A 285.0 256.0 11 26 15 11 [[133, 383]] 1.0 6hjj CAMK_AURKA_HUMAN CAMK 4.1e-78 268.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2C6EA O14965 127 389 403.0 HPM:61389 Type1.5_Back Inactive DFGout 13.8284 10.5042 BBAminus -107.5, 166.44 -107.98, 77.13 -86.33, -35.22 287.99, 100.84 -90.9, 43.1 out-out out 12.2357 Saltbr-out 11.4051 HRD-in -84.92, -60.14 72.68, 11.22 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 89.24 APE8-dihe-in -59.23, 168.18 APE8-rot-out 37.94 APE67-dihe-in -43.87, -36.15 -54.57, -39.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.3931 None None None XRAY 2.1 0.2 0.27 A 283.0 251.0 12 26 14 12 [[133, 383]] 1.0 2c6e CAMK_AURKA_HUMAN CAMK 1.7e-79 272.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 6VPJA O14965 104 389 403.0 ANP:60401 ATPlike Inactive DFGout 12.8705 10.5737 None -110.21, 156.22 -91.65, 36.01 -66.52, 152.83 298.69, 154.8 77.13, 20.04 out-out out 11.1099 Saltbr-out 9.2857 HRD-out -138.11, 171.42 -106.7, -171.48 out-out-out SNCooo out-out ActLoopNT-out 12.6593 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -97.02, 1.42 APE9-dihe-na 78.4, 140.83 APE8-dihe-out -96.06, -166.39 APE8-rot-out 60.44 APE67-dihe-in -59.33, -27.82 -96.84, 6.17 APE12-dist-in 11.6479 APE11-dist-in 13.2558 APE10-dist-out 10.9109 APE9-dist-out 17.2151 None None None XRAY 2.1 0.192 0.215 A 292.0 263.0 3 26 23 3 [[133, 383]] 1.0 6vpj CAMK_AURKA_HUMAN CAMK 7.7e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 6VPHA O14965 7 389 403.0 ANP:60604 ATPlike Inactive DFGout 13.6713 11.5565 None -98.71, -169.93 -135.39, 50.18 -66.9, 153.36 295.81, 141.3 65.48, 29.39 out-out out 11.3786 Saltbr-out 9.7752 HRD-out -105.53, 132.54 -112.81, 142.85 out-out-out SNCooo out-out ActLoopNT-out 14.5801 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na -129.35, -34.6 APE9-dihe-na -51.22, -37.08 APE8-dihe-out -65.53, -18.81 APE8-rot-out 65.19 APE67-dihe-in -56.69, -28.96 -65.95, -34.72 APE12-dist-out 14.7601 APE11-dist-in 9.582 APE10-dist-out 12.2573 APE9-dist-out 21.2222 None TPO287,TPO288 CAS247,TPO287,TPO288,CAS290 XRAY 2.14 0.189 0.216 A 292.0 267.0 0 26 26 0 [[133, 383]] 1.0 6vph CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4JAIA O14965 126 390 403.0 XU2:401 Type1 Inactive DFGout 13.4027 10.2629 None -152.02, 87.23 -129.85, 140.53 -120.2, 999.0 47.34, 110.12 999.0, 999.0 out-out out 12.2973 Saltbr-out 11.3549 HRD-out 48.66, 43.27 -47.21, 145.24 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 116.6 APE8-rot-none 999.0 APE67-dihe-out -39.38, -34.35 148.2, -90.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.231 0.318 A 284.0 249.0 16 26 10 16 [[133, 383]] 1.0 4jai CAMK_AURKA_HUMAN CAMK 7.6e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 7AYHA O14965 125 390 403.0 S9H:501 Type1 Inactive DFGout 13.2217 10.4516 None -95.37, 143.61 -150.54, 155.43 -134.42, 999.0 174.18, 77.34 999.0, 999.0 out-out out 11.6983 Saltbr-out 8.8043 HRD-out -139.13, 166.73 -120.69, -52.37 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -40.89 APE8-rot-out 55.24 APE67-dihe-in -44.53, -29.55 -58.37, -31.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.275 0.313 A 285.0 250.0 16 26 10 16 [[133, 383]] 1.0 7ayh CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 7O2VA O14965 117 390 403.0 V0K:501 Type1 Inactive DFGout 12.6363 13.6464 None -115.24, -11.79 -83.13, 152.19 -88.8, 25.64 80.27, 118.54 -80.07, 61.89 out-out out 12.5796 Saltbr-out 11.4396 HRD-out -97.73, 141.11 -72.32, -153.11 out-out-out SNCooo out-out ActLoopNT-out 5.824 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -102.92 APE9-dihe-na 47.32, -129.13 APE8-dihe-in -68.33, 139.24 APE8-rot-in 291.4 APE67-dihe-in -46.53, -31.36 -88.23, -5.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.9763 APE9-dist-out 12.3162 None None None XRAY 3.1 0.275 0.329 A 299.0 264.0 10 26 16 10 [[133, 383]] 1.0 7o2v CAMK_AURKA_HUMAN CAMK 9.1e-80 273.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3O51A O14965 126 388 403.0 LJF:1 Type1.5_Front Inactive DFGout 12.9209 9.2148 None -125.94, 46.56 -78.14, 156.47 -164.09, 999.0 59.42, 112.33 999.0, 999.0 out-none out 12.8625 Saltbr-none 999.0 HRD-out -126.02, 153.87 -92.88, -115.51 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -57.91, -10.7 999.0, -51.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.288 0.304 A 267.0 246.0 17 26 9 17 [[133, 383]] 1.0 3o51 CAMK_AURKA_HUMAN CAMK 6e-80 274.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 6HJKA O14965 127 391 403.0 G7W:501 Type1.5_Front Inactive DFGout 16.1697 11.0281 None -98.89, -43.18 56.05, 51.38 -26.46, 122.09 241.09, 49.93 -75.8, 146.41 out-none out 11.5126 Saltbr-none 999.0 HRD-out -101.06, -164.07 153.73, -179.93 none-out-out SNCnoo out-out ActLoopNT-out 20.1842 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -66.21 APE9-dihe-na -150.91, 1.99 APE8-dihe-out -109.25, 19.55 APE8-rot-in 313.76 APE67-dihe-in -56.8, -21.9 -54.42, -38.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.6518 APE9-dist-out 13.8287 L210C,C290A,C393A None None XRAY 2.4 0.219 0.252 A 285.0 255.0 10 26 16 10 [[133, 383]] 1.0 6hjk CAMK_AURKA_HUMAN CAMK 4.1e-78 268.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 6C83A O14965 127 389 403.0 ACP:501 ATPlike Inactive None 999.0 999.0 None -115.58, 146.0 -134.74, 164.64 -155.95, 999.0 999.0, 999.0 999.0, 999.0 out-none out 12.2939 Saltbr-none 999.0 HRD-out 57.31, 86.65 -118.52, 133.44 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -76.52 APE8-dihe-out -81.29, 5.34 APE8-rot-out 166.86 APE67-dihe-in -68.45, -16.44 -75.67, -23.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.2563 None None None XRAY 2.55 0.268 0.322 A 285.0 248.0 15 26 11 15 [[133, 383]] 1.0 6c83 CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2WQEA O14965 127 388 403.0 ADP:1389,ADP:1390,ADP:1391 ATPlike,ATPlike,ATPlike Inactive None 999.0 999.0 None -107.12, -44.35 28.24, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 12.4276 Saltbr-none 999.0 HRD-out -82.99, 160.23 -97.32, -44.1 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -56.47 APE8-dihe-out -79.62, -22.51 APE8-rot-in 267.0 APE67-dihe-in -40.62, -26.16 -46.48, -55.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.7962 S155R None None XRAY 2.5 0.206 0.251 A 262.0 241.0 21 26 10 16 [[133, 383]] 1.0 2wqe CAMK_AURKA_HUMAN CAMK 9.7e-80 273.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 5OBRA O14965 126 390 403.0 9QT:401,SKE:402 Allosteric,Type1 Inactive None 11.9936 14.1133 None -120.85, 175.9 49.64, 111.5 91.55, -154.11 257.58, 58.97 124.57, 54.88 out-out out 11.6699 Saltbr-out 7.51 HRD-in -87.06, -37.27 63.65, 5.21 out-out-out SNCooo out-out ActLoopNT-out 5.706 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 174.71 APE8-dihe-in -48.88, 148.85 APE8-rot-out 188.4 APE67-dihe-in -53.11, -27.71 -92.05, -5.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6313 None None None XRAY 2.62 0.226 0.292 A 272.0 255.0 10 26 16 10 [[133, 383]] 1.0 5obr CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3W2CC O14965 128 388 403.0 N15:401 Type1 Inactive None 999.0 999.0 None -119.65, 152.46 84.37, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 13.8507 Saltbr-out 14.4223 HRD-none 999.0, 999.0 999.0, 999.0 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -102.95 APE8-rot-in 346.67 APE67-dihe-in -33.77, -43.59 -64.85, -45.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.45 0.256 0.32 C 261.0 202.0 59 26 9 17 [[133, 383]] 1.0 3w2c CAMK_AURKA_HUMAN CAMK 5.5e-80 274.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3W2CE O14965 128 388 403.0 N15:401 Type1 Inactive None 999.0 999.0 None -123.91, 159.82 65.31, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 12.9062 Saltbr-out 10.7606 HRD-none 999.0, 999.0 999.0, 999.0 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -62.35 APE8-rot-in 314.5 APE67-dihe-in -33.57, -39.05 -86.05, -41.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.45 0.256 0.32 E 261.0 202.0 59 26 9 17 [[133, 383]] 1.0 3w2c CAMK_AURKA_HUMAN CAMK 5.5e-80 274.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2X81A O14965 127 388 403.0 ZZL:1389 Type1 Inactive None 999.0 999.0 None -101.61, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 11.6574 Saltbr-none 999.0 HRD-in -75.09, -52.06 78.45, -27.83 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -158.98 APE8-dihe-in -83.83, 140.8 APE8-rot-out 188.92 APE67-dihe-in -38.04, -33.42 -91.87, -17.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2972 None None None XRAY 2.91 0.247 0.303 A 272.0 242.0 20 26 9 17 [[133, 383]] 1.0 2x81 CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3W18A O14965 126 388 403.0 N13:501 Type1 Inactive None 999.0 999.0 None -149.38, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 13.4813 Saltbr-out 16.091 HRD-out -82.01, 154.07 -81.44, -109.81 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -171.61 APE8-dihe-out -85.64, -13.77 APE8-rot-out 180.75 APE67-dihe-in -53.11, -25.2 -58.82, -47.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.9572 None None None XRAY 2.5 0.244 0.315 A 278.0 234.0 29 26 9 17 [[133, 383]] 1.0 3w18 CAMK_AURKA_HUMAN CAMK 7e-80 274.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3W18B O14965 126 388 403.0 N13:501 Type1 Inactive None 999.0 999.0 None -134.47, -22.52 -99.45, 108.96 24.17, -97.42 999.0, 999.0 76.76, 11.53 none-none none 999.0 Saltbr-none 999.0 HRD-out -88.0, 136.09 -55.61, -107.06 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -45.74 APE8-dihe-out -74.68, -8.8 APE8-rot-out 190.63 APE67-dihe-in -49.12, -35.84 -75.77, -37.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.6107 None None None XRAY 2.5 0.244 0.315 B 278.0 236.0 27 26 13 13 [[133, 383]] 1.0 3w18 CAMK_AURKA_HUMAN CAMK 7e-80 274.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4B0GA O14965 126 391 403.0 VEK:1392 Type1 Inactive None 999.0 999.0 None -124.76, 65.78 -126.11, 153.32 -100.51, 32.83 999.0, 999.0 -102.67, 15.93 out-out out 11.7537 Saltbr-out 9.485 HRD-out -122.36, 147.21 -84.03, -142.19 out-out-out SNCooo out-out ActLoopNT-out 5.3495 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.07 APE8-rot-out 159.6 APE67-dihe-in -43.66, -29.16 -52.83, -44.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.205 0.263 A 283.0 247.0 19 26 14 12 [[133, 383]] 1.0 4b0g CAMK_AURKA_HUMAN CAMK 7.5e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 4BYJA O14965 126 388 403.0 FH5:1 Type1 Inactive None 999.0 999.0 None -109.39, 158.27 56.84, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 11.9983 Saltbr-out 7.845 HRD-out -133.37, 10.3 42.08, -54.53 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -4.7 APE8-rot-out 202.32 APE67-dihe-in -55.76, -21.63 -64.81, -35.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.232 0.248 A 285.0 246.0 17 26 9 17 [[133, 383]] 1.0 4byj CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3H0ZB O14965 126 388 403.0 45B:1 Type1 Inactive None 999.0 999.0 None -73.44, -144.2 -78.25, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 11.4286 Saltbr-out 6.8707 HRD-out 62.03, 82.81 -108.53, 139.38 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 101.15 APE8-rot-out 186.62 APE67-dihe-in -39.91, -40.23 -75.74, -20.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K124A,T287A,T288A None None XRAY 2.92 0.221 0.286 B 268.0 240.0 23 26 9 17 [[133, 383]] 1.0 3h0z CAMK_AURKA_HUMAN CAMK 3.9e-79 271.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3H0ZC O14965 126 388 403.0 45B:1 Type1 Inactive None 999.0 999.0 None -154.11, 41.53 -98.85, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 12.8049 Saltbr-out 10.0054 HRD-out -67.65, 130.12 -81.39, -32.74 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 109.45 APE8-rot-out 167.45 APE67-dihe-in -45.08, -49.33 -107.53, 4.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K124A,T287A,T288A None None XRAY 2.92 0.221 0.286 C 268.0 246.0 17 26 9 17 [[133, 383]] 1.0 3h0z CAMK_AURKA_HUMAN CAMK 3.9e-79 271.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3COHA O14965 128 388 403.0 83H:1 Type1 Inactive None 999.0 999.0 None -152.33, 69.84 -83.9, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 10.9213 Saltbr-out 5.518 HRD-out 59.23, 23.98 -59.97, 130.51 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 157.25, -27.9 APE9-dihe-na -72.13, -171.14 APE8-dihe-in -87.76, 105.63 APE8-rot-in 312.46 APE67-dihe-in -38.16, -47.94 -61.77, -30.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.4094 K124A,Q154N,A203S,R251K,T287A,T288A,E336D None None XRAY 2.7 0.249 0.28 A 268.0 247.0 14 26 12 14 [[133, 383]] 1.0 3coh CAMK_AURKA_HUMAN CAMK 6.8e-79 270.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3COHB O14965 128 388 403.0 83H:2 Type1 Inactive None 999.0 999.0 None -152.27, 69.79 -84.21, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 10.8967 Saltbr-out 5.5574 HRD-out 57.18, 24.4 -60.63, 130.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 156.6, -25.86 APE9-dihe-na -73.98, -172.9 APE8-dihe-in -86.31, 108.51 APE8-rot-in 309.97 APE67-dihe-in -38.32, -45.55 -61.11, -32.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.4236 K124A,Q154N,A203S,R251K,T287A,T288A,E336D None None XRAY 2.7 0.249 0.28 B 268.0 247.0 14 26 12 14 [[133, 383]] 1.0 3coh CAMK_AURKA_HUMAN CAMK 6.8e-79 270.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3QBNA O14965 126 388 403.0 E9Z:1 Type1 Inactive None 999.0 999.0 None -129.73, 92.91 -54.77, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 12.8923 Saltbr-out 9.6775 HRD-out -87.09, 152.8 -108.3, -67.47 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -136.83, -66.52 APE9-dihe-na -169.05, -176.59 APE8-dihe-in -73.14, 145.1 APE8-rot-in 328.56 APE67-dihe-in -69.55, -10.29 -123.67, 37.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.1803 V279C,C290S,C393S None None XRAY 3.5 0.257 0.334 A 281.0 250.0 13 26 13 13 [[133, 383]] 1.0 3qbn CAMK_AURKA_HUMAN CAMK 7.6e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3W2CA O14965 128 388 403.0 N15:401 Type1.5_Back Inactive None 999.0 999.0 None -119.68, 158.18 72.13, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 13.333 Saltbr-out 13.2922 HRD-none 999.0, 999.0 999.0, 999.0 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -105.03 APE8-rot-out 176.61 APE67-dihe-in -28.13, -45.18 -62.37, -55.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.45 0.256 0.32 A 261.0 203.0 58 26 9 17 [[133, 383]] 1.0 3w2c CAMK_AURKA_HUMAN CAMK 5.5e-80 274.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3W2CG O14965 128 388 403.0 N15:401 Type1.5_Back Inactive None 999.0 999.0 None -124.56, -177.92 59.84, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 12.9554 Saltbr-out 11.8849 HRD-none 999.0, 999.0 999.0, 999.0 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -79.06 APE8-rot-out 175.53 APE67-dihe-in -38.36, -27.94 -71.96, -40.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.45 0.256 0.32 G 261.0 202.0 59 26 9 17 [[133, 383]] 1.0 3w2c CAMK_AURKA_HUMAN CAMK 5.5e-80 274.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 2C6EB O14965 127 388 403.0 HPM:61388 Type1.5_Front Inactive None 999.0 999.0 None -108.73, 147.84 100.58, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 12.3335 Saltbr-out 11.7069 HRD-in -74.71, -88.37 86.19, 28.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -90.56 APE8-dihe-out -69.38, -179.33 APE8-rot-out 55.29 APE67-dihe-in -54.24, -12.3 -58.45, -38.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.5658 None None None XRAY 2.1 0.2 0.27 B 283.0 246.0 16 26 10 16 [[133, 383]] 1.0 2c6e CAMK_AURKA_HUMAN CAMK 1.7e-79 272.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA 3MYGA O14965 126 388 403.0 EML:1 Type1 None DFGin 6.6394 15.8274 BLAminus -122.31, -179.48 56.93, 60.99 -81.36, 19.85 281.57, 75.82 -60.89, -48.59 in-in in 8.8952 Saltbr-in 2.9006 HRD-in -65.99, -46.93 66.41, -15.04 in-in-none SNCiin in-none ActLoopNT-in 2.9842 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 158.04 APE8-rot-in 313.0 APE67-dihe-in -30.25, -41.2 -89.45, -15.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.222 0.245 A 272.0 252.0 11 26 15 11 [[133, 383]] 1.0 3myg CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A

CAMK_AURKA (Aurora kinase A)

Total number of chains: 243
Active chains: 7
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 108 44.4% AF-O14965-K1A
DFGinter None 68 28.0% 5L8LA
DFGin None 21 8.6% 2J4ZB
DFGin ABAminus 18 7.4% 3E5AA
None None 18 7.4% 5OBRA
DFGout None 7 2.9% 6VPHA
DFGin BLAplus 1 0.4% 4J8MA
DFGin BLBminus 1 0.4% 8PR7D
DFGout BBAminus 1 0.4% 2C6EA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AURKA AURKA_HUMAN 1OL5A O14965 123 388 403.0 ADP:1388 ATPlike Active DFGin 5.5782 15.0961 BLAminus -139.2, -172.08 52.22, 80.16 -90.83, 24.66 282.61, 72.55 -49.87, -44.18 in-in in 9.4508 Saltbr-in 2.9117 HRD-in -63.28, -60.88 73.6, 1.59 in-in-in SNCiii in-in ActLoopNT-in 2.9276 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.42, 162.5 APE9-dihe-na 119.45, -153.19 APE8-dihe-in -110.77, 140.24 APE8-rot-in 313.06 APE67-dihe-in -62.23, -14.3 -43.16, -62.5 APE12-dist-in 8.1744 APE11-dist-in 10.9573 APE10-dist-in 5.2741 APE9-dist-in 3.683 None TPO287,TPO288 TPO287,TPO288 XRAY 2.5 0.194 0.252 A 282.0 266.0 0 26 26 0 [[133, 383]] 1.0 1ol5 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 6VPGA O14965 7 389 403.0 ANP:60401 ATPlike Active DFGin 5.3184 15.0701 BLAminus -133.54, 176.05 56.91, 81.54 -90.61, 23.9 286.39, 75.22 -62.73, -9.76 in-in in 9.8844 Saltbr-in 2.9538 HRD-in -72.51, -51.0 67.55, 11.3 in-in-in SNCiii in-in ActLoopNT-in 3.0433 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.96, 159.16 APE9-dihe-na 122.67, -152.53 APE8-dihe-in -117.94, 146.39 APE8-rot-in 309.68 APE67-dihe-in -61.83, -12.97 -52.19, -62.88 APE12-dist-in 8.5172 APE11-dist-in 11.4274 APE10-dist-in 5.7242 APE9-dist-in 3.8329 None TPO287,TPO288 TPO287,TPO288 XRAY 2.64 0.204 0.245 A 292.0 267.0 0 26 26 0 [[133, 383]] 1.0 6vpg Homo sapiens CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5LXMA O14965 126 392 403.0 ADP:60501 ATPlike Active DFGin 5.3906 14.9756 BLAminus -135.45, -179.78 54.7, 80.97 -90.8, 30.12 283.16, 71.51 -72.4, -3.16 in-in in 9.2473 Saltbr-in 2.7237 HRD-in -74.23, -48.55 66.99, 5.01 in-in-in SNCiii in-in ActLoopNT-in 3.1136 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.91, 137.37 APE9-dihe-na 128.62, -150.21 APE8-dihe-in -129.87, 142.81 APE8-rot-in 303.47 APE67-dihe-in -69.71, -10.62 -37.99, -61.07 APE12-dist-in 8.2574 APE11-dist-in 10.6918 APE10-dist-in 5.2126 APE9-dist-in 3.2978 C290A,C393A TPO288 TPO288 XRAY 2.08 0.202 0.243 A 283.0 267.0 0 26 26 0 [[133, 383]] 1.0 5lxm Homo sapiens CAMK_AURKA_HUMAN CAMK 9.2e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5G1XA O14965 126 389 403.0 ADP:1390 ATPlike Active DFGin 5.3433 15.03 BLAminus -132.86, -170.57 52.68, 76.5 -90.96, 13.96 279.12, 78.43 -59.51, -20.51 in-in in 9.2783 Saltbr-in 2.828 HRD-in -82.61, -50.12 70.7, 5.33 in-in-in SNCiii in-in ActLoopNT-in 2.9632 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.42, -179.26 APE9-dihe-na 65.74, -155.89 APE8-dihe-in -128.23, 121.78 APE8-rot-in 304.75 APE67-dihe-in -61.27, -19.7 -46.07, -47.67 APE12-dist-in 8.2472 APE11-dist-in 10.7994 APE10-dist-in 5.5303 APE9-dist-in 3.699 C290A,C393A TPO288 TPO288 XRAY 1.72 0.177 0.195 A 285.0 264.0 0 26 26 0 [[133, 383]] 1.0 5g1x Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 7ZTLA O14965 126 389 403.0 ADP:501,BCN:506 ATPlike,Allosteric Active DFGin 5.6229 15.1084 BLAminus -131.55, 179.55 58.91, 75.38 -87.97, 22.52 281.42, 69.29 -65.3, -21.25 in-in in 9.2252 Saltbr-in 2.815 HRD-in -81.87, -52.88 75.2, 3.05 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.79, 177.44 APE9-dihe-na 70.08, -157.96 APE8-dihe-in -126.05, 125.84 APE8-rot-in 309.73 APE67-dihe-in -58.88, -23.16 -51.84, -48.56 APE12-dist-in 8.1263 APE11-dist-in 10.6011 APE10-dist-in 5.3541 APE9-dist-in 3.7652 C290A,K339C,C393A TPO288 TPO288 XRAY 1.9 0.165 0.193 A 309.0 264.0 0 26 26 0 [[133, 383]] 1.0 7ztl Homo sapiens CAMK_AURKA_HUMAN CAMK 4.2e-78 268.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN AF-O14965-K1A O14965 125 391 403.0 No_ligand No_ligand Active DFGin 5.5289 14.8803 BLAminus -132.48, -179.84 57.24, 70.17 -79.24, 16.4 282.35, 77.01 -58.05, -32.04 in-in in 9.2276 Saltbr-in 2.708 HRD-in -80.88, -51.09 67.96, 12.7 in-in-in SNCiii in-in ActLoopNT-in 2.9572 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.18, 173.11 APE9-dihe-na 86.42, -161.65 APE8-dihe-in -116.22, 122.78 APE8-rot-in 305.5 APE67-dihe-in -58.7, -20.28 -46.82, -49.92 APE12-dist-in 8.4312 APE11-dist-in 11.2268 APE10-dist-in 5.5558 APE9-dist-in 3.551 None None None AF2 -1.0 1.0 1.0 A 267.0 267.0 0 26 26 0 [[133, 383]] 1.0 AF-O14965-K1 Homo sapiens CAMK_AURKA_HUMAN CAMK 6e-80 274.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN AF-O14965-K3A O14965 125 391 403.0 No_ligand No_ligand Active DFGin 5.6976 15.2161 BLAminus -127.1, 175.03 53.67, 75.17 -77.09, 18.89 286.79, 79.82 -57.24, -36.78 in-in in 9.9525 Saltbr-in 2.8263 HRD-in -82.42, -50.55 68.17, 14.97 in-in-in SNCiii in-in ActLoopNT-in 2.9389 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.94, 160.76 APE9-dihe-na 99.46, -154.48 APE8-dihe-in -120.71, 133.3 APE8-rot-in 307.63 APE67-dihe-in -63.76, -17.86 -47.79, -50.9 APE12-dist-in 8.7606 APE11-dist-in 11.2833 APE10-dist-in 5.5717 APE9-dist-in 3.5882 None None None AF2 -1.0 1.0 1.0 A 267.0 267.0 0 26 26 0 [[133, 383]] 1.0 AF-O14965-K3 Homo sapiens CAMK_AURKA_HUMAN CAMK 6e-80 274.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4C3PD O14965 125 390 403.0 ACP:1391 ATPlike Inactive DFGin 5.0797 15.0907 ABAminus -119.78, -23.96 -110.92, 146.31 -144.29, 22.56 288.75, 97.88 -63.46, -34.21 out-out out 11.1639 Saltbr-out 5.9729 HRD-out -75.78, -41.12 71.55, -101.13 out-in-out SNCoio in-out ActLoopNT-in 3.1113 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nooo APE10-dihe-na -140.51, -146.18 APE9-dihe-na 83.68, 6.59 APE8-dihe-out -140.3, 13.24 APE8-rot-out 207.12 APE67-dihe-in -44.87, -30.51 -70.19, -27.98 APE12-dist-none 999.0 APE11-dist-out 20.8704 APE10-dist-out 24.1292 APE9-dist-out 28.582 None None None XRAY 2.69 0.205 0.289 D 282.0 260.0 6 26 20 6 [[133, 383]] 1.0 4c3p Homo sapiens CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 8GUWA O14965 506 388 403.0 ADP:60501 ATPlike Inactive DFGin 5.4961 16.0011 ABAminus -116.4, -50.49 -101.78, 116.28 -108.31, 28.43 281.67, 88.04 -72.88, -24.68 out-out out 11.7793 Saltbr-out 6.9626 HRD-out -52.32, 144.81 -137.03, 32.44 out-in-out SNCoio in-out ActLoopNT-in 2.989 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 154.24 APE8-dihe-in -135.99, 160.18 APE8-rot-out 182.57 APE67-dihe-in -45.22, -30.26 -102.15, -5.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 22.8351 C290A,C393A None None XRAY 2.7 0.216 0.258 A 304.0 259.0 7 26 19 7 [[133, 383]] 1.0 8guw Homo sapiens CAMK_AURKA_HUMAN CAMK 1.2e-78 270.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 8GUWB O14965 507 390 403.0 ADP:60501 ATPlike Inactive DFGin 5.2903 15.6844 ABAminus -103.46, -56.86 -84.59, 164.71 -149.11, 43.73 280.55, 102.4 -37.77, -51.78 out-out out 11.2219 Saltbr-out 10.1241 HRD-out -88.2, 114.65 -57.32, -35.01 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 120.59 APE8-rot-out 188.97 APE67-dihe-out 79.95, -4.59 -68.08, -173.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C290A,C393A None None XRAY 2.7 0.216 0.258 B 304.0 250.0 13 26 13 13 [[133, 383]] 1.0 8guw Homo sapiens CAMK_AURKA_HUMAN CAMK 1.2e-78 270.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 8GUWC O14965 506 388 403.0 ADP:60501 ATPlike Inactive DFGin 5.7941 16.123 ABAminus -112.39, -57.42 -66.39, 155.71 -143.31, 23.7 266.43, 102.44 -50.18, -24.58 out-out out 11.5307 Saltbr-out 6.1466 HRD-out -98.37, 113.81 -121.54, 28.92 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -46.16 APE8-rot-in 299.01 APE67-dihe-in -63.17, -8.64 -58.96, -54.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C290A,C393A None None XRAY 2.7 0.216 0.258 C 304.0 248.0 18 26 12 14 [[133, 383]] 1.0 8guw Homo sapiens CAMK_AURKA_HUMAN CAMK 1.2e-78 270.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5DPVA O14965 127 389 403.0 5DN:401,SKE:402 Allosteric,Type1 Inactive DFGin 6.2227 16.2094 ABAminus -110.93, -43.26 -110.84, 101.02 -87.51, 23.53 278.79, 82.59 -59.61, -51.22 out-in out 10.5383 Saltbr-in 3.388 HRD-in -62.88, -51.13 56.61, 19.56 in-in-out SNCiio in-out ActLoopNT-in 3.1231 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 144.36 APE9-dihe-na -94.43, -124.73 APE8-dihe-in -73.05, 138.31 APE8-rot-in 266.66 APE67-dihe-in -36.64, -38.36 -81.1, -11.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.4807 APE9-dist-out 10.3541 T287A None None XRAY 2.285 0.225 0.28 A 273.0 257.0 6 26 20 6 [[133, 383]] 1.0 5dpv Homo sapiens CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5DR6A O14965 127 390 403.0 5E1:401,SKE:402 Allosteric,Type1 Inactive DFGin 6.2554 16.2435 ABAminus -109.16, -45.28 -112.39, 100.25 -88.77, 25.04 278.19, 83.44 -61.53, -50.53 out-in out 10.5931 Saltbr-in 3.4325 HRD-in -66.11, -48.32 65.82, 8.05 in-in-out SNCiio in-out ActLoopNT-in 2.9691 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 145.11 APE9-dihe-na -94.91, -119.28 APE8-dihe-in -76.91, 137.76 APE8-rot-in 267.0 APE67-dihe-in -38.0, -37.59 -81.57, -10.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.3936 APE9-dist-out 10.6234 T287A None None XRAY 2.534 0.221 0.278 A 273.0 257.0 7 26 19 7 [[133, 383]] 1.0 5dr6 Homo sapiens CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2WTWA O14965 128 389 403.0 ZZL:1390 Type1 Inactive DFGin 5.0295 15.5299 ABAminus -106.44, -45.36 -104.13, 150.11 -135.47, 26.63 287.92, 83.14 -51.9, -25.54 out-out out 11.468 Saltbr-out 6.0234 HRD-in -69.03, -60.65 76.28, -17.41 out-in-out SNCoio in-out ActLoopNT-in 2.8667 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 10.4 APE9-dihe-na -133.69, -108.65 APE8-dihe-in -91.45, 126.3 APE8-rot-in 315.62 APE67-dihe-in -56.65, -42.97 -87.39, -8.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.6426 APE9-dist-out 10.3699 L215R,T217E,R220K None None XRAY 3.302 0.236 0.288 A 285.0 256.0 6 26 20 6 [[133, 383]] 1.0 2wtw Homo sapiens CAMK_AURKA_HUMAN CAMK 2.7e-81 278.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3E5AA O14965 125 389 403.0 VX6:500 Type1 Inactive DFGin 5.6075 15.6633 ABAminus -111.1, -40.76 -107.64, 114.77 -109.11, 20.41 286.45, 70.32 -57.36, -21.14 out-out out 10.6576 Saltbr-out 4.0692 HRD-in -71.98, -58.6 78.66, 11.03 out-in-in SNCoii in-in ActLoopNT-in 2.9414 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.8, 157.55 APE9-dihe-na 131.17, -154.51 APE8-dihe-in -121.72, 132.24 APE8-rot-in 299.23 APE67-dihe-in -74.97, -7.03 -28.17, -59.24 APE12-dist-in 8.1153 APE11-dist-in 10.9246 APE10-dist-in 5.2926 APE9-dist-in 3.622 None TPO288 TPO288 XRAY 2.3 0.206 0.256 A 268.0 265.0 0 26 26 0 [[133, 383]] 1.0 3e5a Homo sapiens CAMK_AURKA_HUMAN CAMK 6.1e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2NP8A O14965 127 388 403.0 CC3:394 Type1 Inactive DFGin 5.2721 16.0857 ABAminus -73.9, -44.35 -158.46, -167.75 -112.0, 8.62 282.84, 84.47 66.12, -157.5 out-out out 10.2017 Saltbr-out 5.7237 HRD-in -71.77, -64.08 70.23, 8.33 out-out-out SNCooo out-out ActLoopNT-out 5.8433 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 150.46 APE8-rot-out 190.14 APE67-dihe-in -48.96, -32.22 -85.8, -12.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.25 0.246 0.283 A 272.0 256.0 6 26 20 6 [[133, 383]] 1.0 2np8 Homo sapiens CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4BYIA O14965 126 388 403.0 FH3:1 Type1 Inactive DFGin 6.0053 15.1891 ABAminus -141.66, 21.53 -149.09, 143.7 -145.26, 27.8 296.46, 87.08 -78.42, -3.39 out-out out 10.1407 Saltbr-out 6.2062 HRD-in -80.19, -45.02 73.31, -36.35 out-in-out SNCoio in-out ActLoopNT-in 3.401 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -173.73 APE8-dihe-in -124.98, 116.87 APE8-rot-out 67.62 APE67-dihe-in -34.41, -45.4 -74.23, -30.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.2654 None None None XRAY 2.6 0.228 0.253 A 285.0 254.0 9 26 17 9 [[133, 383]] 1.0 4byi Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5ONEA O14965 127 391 403.0 9YQ:501 Type1 Inactive DFGin 4.5128 14.1346 ABAminus -105.31, -16.61 -81.48, 101.61 -122.99, 46.52 291.01, 77.01 95.14, 137.46 out-out out 11.5001 Saltbr-out 10.444 HRD-out -147.52, 134.98 -129.66, 144.77 out-out-out SNCooo out-out ActLoopNT-out 20.0081 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nooo APE10-dihe-na -112.99, 40.69 APE9-dihe-na -63.7, -27.3 APE8-dihe-out -60.7, -55.87 APE8-rot-out 51.63 APE67-dihe-in -60.28, -29.51 -61.01, -28.3 APE12-dist-none 999.0 APE11-dist-out 21.8053 APE10-dist-out 20.4835 APE9-dist-out 14.8011 None None None XRAY 2.6 0.211 0.26 A 285.0 257.0 8 26 18 8 [[133, 383]] 1.0 5one Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5DT0A O14965 127 390 403.0 SKE:401 Type1 Inactive DFGin 6.5507 16.3624 ABAminus -112.57, -43.63 -110.17, 94.56 -84.52, 17.21 279.45, 83.16 -58.42, -46.55 in-in in 9.1873 Saltbr-in 2.524 HRD-in -64.82, -50.09 61.67, 8.23 in-in-out SNCiio in-out ActLoopNT-in 3.1265 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 140.94 APE9-dihe-na -97.93, -126.07 APE8-dihe-in -73.71, 138.78 APE8-rot-in 266.46 APE67-dihe-in -37.39, -37.4 -82.91, -12.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.0428 APE9-dist-out 10.5837 None None None XRAY 2.15 0.211 0.225 A 273.0 259.0 5 26 21 5 [[133, 383]] 1.0 5dt0 Homo sapiens CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3UODA O14965 124 389 403.0 0C3:1 Type1 Inactive DFGin 5.6651 15.2943 ABAminus -104.18, -60.78 -102.1, 108.06 -93.68, 11.03 272.93, 73.56 -44.02, -46.62 out-out out 10.1446 Saltbr-out 3.9294 HRD-in -79.65, -64.13 75.58, -18.62 out-in-out SNCoio in-out ActLoopNT-in 2.8871 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -98.48, 5.26 APE9-dihe-na 100.33, 142.31 APE8-dihe-in -67.88, 163.0 APE8-rot-out 221.97 APE67-dihe-in -55.37, -29.0 -54.05, -38.29 APE12-dist-in 12.8602 APE11-dist-in 9.3556 APE10-dist-in 6.3401 APE9-dist-out 6.0529 T287D None None XRAY 2.5 0.205 0.262 A 279.0 266.0 0 26 26 0 [[133, 383]] 1.0 3uod Homo sapiens CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3UP2A O14965 124 389 403.0 0C8:1 Type1 Inactive DFGin 5.5895 15.653 ABAminus -108.06, -50.92 -103.25, 118.74 -107.45, 26.55 279.5, 74.04 -56.09, -30.67 out-out out 10.2757 Saltbr-out 3.8134 HRD-in -77.31, -62.33 77.13, 0.55 out-in-out SNCoio in-out ActLoopNT-in 2.9148 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -109.08, -27.68 APE9-dihe-na -96.57, -165.23 APE8-dihe-in -53.13, 139.16 APE8-rot-out 185.41 APE67-dihe-in -51.24, -31.12 -79.62, -9.19 APE12-dist-in 12.2079 APE11-dist-in 10.7242 APE10-dist-out 11.2807 APE9-dist-out 10.3496 T287D None None XRAY 2.3 0.208 0.249 A 279.0 266.0 0 26 26 0 [[133, 383]] 1.0 3up2 Homo sapiens CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4DEAA O14965 124 389 403.0 NHI:504 Type1 Inactive DFGin 5.6269 15.4778 ABAminus -117.07, -34.04 -114.57, 105.92 -93.81, 27.91 288.17, 68.74 -50.21, -53.74 out-out out 10.4648 Saltbr-out 4.506 HRD-in -81.18, -46.28 61.2, 2.92 out-in-out SNCoio in-out ActLoopNT-in 2.8982 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -100.72, -36.57 APE9-dihe-na -78.58, -159.26 APE8-dihe-in -78.39, 167.49 APE8-rot-out 61.53 APE67-dihe-in -35.68, -36.82 -94.96, -2.96 APE12-dist-in 11.6423 APE11-dist-in 10.7252 APE10-dist-out 10.9639 APE9-dist-out 10.1521 T287D None None XRAY 2.45 0.218 0.262 A 279.0 266.0 0 26 26 0 [[133, 383]] 1.0 4dea Homo sapiens CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5AAFA O14965 126 388 403.0 NL4:1001 Type1 Inactive DFGin 5.5084 15.7194 ABAminus -104.3, -69.43 -80.91, 136.22 -128.28, 19.02 282.29, 79.75 -69.18, -0.39 in-out in 9.8684 Saltbr-out 4.1218 HRD-in -74.86, -18.1 40.15, -49.95 out-in-out SNCoio in-out ActLoopNT-in 3.0723 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -175.93 APE8-dihe-in -99.34, 126.72 APE8-rot-out 58.55 APE67-dihe-in -42.07, -35.54 -95.24, -28.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.6377 C290A,C393A None None XRAY 2.78 0.242 0.287 A 285.0 254.0 9 26 17 9 [[133, 383]] 1.0 5aaf Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5AAGA O14965 127 388 403.0 6F2:1389 Type1 Inactive DFGin 5.5441 15.7627 ABAminus -109.01, -72.62 -67.08, 138.0 -133.77, 27.29 277.09, 81.16 -59.87, -35.8 out-none out 10.5895 Saltbr-none 999.0 HRD-in -77.69, -43.47 68.09, -55.11 none-in-out SNCnio in-out ActLoopNT-in 3.0359 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -177.15 APE8-dihe-in -100.49, 120.02 APE8-rot-out 59.29 APE67-dihe-in -48.12, -28.49 -91.69, -17.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2644 C290A,C393A None None XRAY 2.85 0.216 0.26 A 285.0 253.0 9 26 17 9 [[133, 383]] 1.0 5aag Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 6GRAA O14965 126 389 403.0 F8Z:501 Type1.5_Front Inactive DFGin 5.0091 16.6676 ABAminus -83.94, -29.2 -118.43, -178.38 -109.45, -4.58 278.61, 93.03 97.03, -121.48 out-out out 11.0182 Saltbr-out 9.6394 HRD-in -78.52, -51.2 68.01, 5.59 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 67.95 APE8-rot-none 999.0 APE67-dihe-in -48.59, -35.52 -71.59, -26.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.213 0.269 A 285.0 250.0 14 26 12 14 [[133, 383]] 1.0 6gra Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4BN1A O14965 126 388 403.0 ADP:1391 ATPlike Inactive DFGin 5.7586 14.9619 BLAminus -135.76, 176.64 57.4, 85.44 -97.06, 20.67 283.26, 70.95 -48.27, -40.43 in-in in 9.2277 Saltbr-in 2.7169 HRD-in -70.78, -55.66 70.88, -1.02 in-in-out SNCiio in-out ActLoopNT-in 2.8 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 16.45, -154.0 APE9-dihe-na 66.92, -173.53 APE8-dihe-in -66.46, 155.86 APE8-rot-out 182.79 APE67-dihe-in -44.49, -32.18 -93.83, -6.12 APE12-dist-in 12.1139 APE11-dist-in 8.7308 APE10-dist-out 13.7066 APE9-dist-out 11.1591 V174M TPO287,TPO288 TPO287,TPO288 XRAY 2.499 0.195 0.244 A 285.0 263.0 0 26 26 0 [[133, 383]] 1.0 4bn1 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.5e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 1MQ4A O14965 126 388 403.0 ADP:2001 ATPlike Inactive DFGin 5.607 15.2135 BLAminus -132.59, 179.34 62.49, 72.25 -91.07, 21.51 279.91, 70.01 -61.32, -27.71 in-in in 9.0551 Saltbr-in 2.8803 HRD-in -82.66, -49.31 72.48, -1.39 in-in-out SNCiio in-out ActLoopNT-in 2.9232 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -97.21, -164.83 APE9-dihe-na -146.02, -127.82 APE8-dihe-in -61.49, 131.42 APE8-rot-out 178.11 APE67-dihe-in -51.42, -34.84 -86.66, -6.25 APE12-dist-in 7.6815 APE11-dist-in 11.8468 APE10-dist-out 10.5866 APE9-dist-out 9.9776 None None None XRAY 1.9 0.229 0.273 A 272.0 261.0 2 26 24 2 [[133, 383]] 1.0 1mq4 Homo sapiens CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5DNRA O14965 126 390 403.0 ATP:403 ATPlike Inactive DFGin 5.6553 15.0245 BLAminus -132.27, -179.72 60.78, 76.64 -90.12, 18.66 275.93, 74.44 -56.64, -35.89 in-in in 9.1663 Saltbr-in 2.7468 HRD-in -79.07, -53.73 71.53, 2.24 in-in-out SNCiio in-out ActLoopNT-in 2.9452 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -125.56, 5.88 APE9-dihe-na -79.83, -178.97 APE8-dihe-in -49.83, 123.63 APE8-rot-in 300.84 APE67-dihe-in -48.83, -30.32 -94.71, -13.22 APE12-dist-in 9.3475 APE11-dist-in 13.1152 APE10-dist-out 15.9471 APE9-dist-out 11.2037 None TPO288 TPO288 XRAY 1.95 0.206 0.226 A 272.0 265.0 0 26 26 0 [[133, 383]] 1.0 5dnr Homo sapiens CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5DT3A O14965 127 390 403.0 ATP:403 ATPlike Inactive DFGin 5.7307 15.0475 BLAminus -138.47, 178.42 59.62, 78.35 -90.84, 24.83 281.41, 74.26 -61.06, -31.68 in-in in 9.4512 Saltbr-in 2.9168 HRD-in -69.42, -55.99 70.31, -3.53 in-in-out SNCiio in-out ActLoopNT-in 2.8923 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -112.53, -5.85 APE9-dihe-na -110.59, -164.26 APE8-dihe-in -61.03, 149.68 APE8-rot-out 193.86 APE67-dihe-in -45.37, -39.19 -93.82, -1.33 APE12-dist-in 12.1815 APE11-dist-in 10.015 APE10-dist-out 11.6945 APE9-dist-out 10.4874 None TPO287 TPO287 XRAY 2.33 0.21 0.243 A 273.0 264.0 0 26 26 0 [[133, 383]] 1.0 5dt3 Homo sapiens CAMK_AURKA_HUMAN CAMK 6.5e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 1OL7A O14965 127 390 403.0 ADP:531 ATPlike Inactive DFGin 5.4287 15.0428 BLAminus -133.12, -167.56 48.98, 74.14 -88.94, 32.44 285.93, 64.91 -57.61, -36.14 in-in in 9.5058 Saltbr-in 3.0551 HRD-in -75.56, -48.34 63.05, 5.8 in-in-out SNCiio in-out ActLoopNT-in 2.9785 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -104.11, 138.56 APE9-dihe-na 156.93, 143.05 APE8-dihe-in -89.37, 102.83 APE8-rot-out 182.11 APE67-dihe-in -15.17, -56.94 -45.24, -37.82 APE12-dist-in 11.2666 APE11-dist-in 11.2056 APE10-dist-out 10.4649 APE9-dist-out 8.2689 None TPO287,TPO288 TPO287,TPO288 XRAY 2.75 0.257 0.296 A 282.0 264.0 0 26 26 0 [[133, 383]] 1.0 1ol7 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5G15A O14965 126 390 403.0 ACP:1391 ATPlike Inactive DFGin 5.983 16.3862 BLAminus -138.69, -169.03 59.87, 67.73 -86.51, 18.94 284.94, 72.05 -48.14, -38.59 out-out out 10.2958 Saltbr-out 5.1725 HRD-in -73.28, -52.04 69.95, 14.4 out-in-in SNCoii in-in ActLoopNT-in 2.9265 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.64, 165.4 APE9-dihe-na 125.58, -148.7 APE8-dihe-in -133.46, 135.34 APE8-rot-in 292.83 APE67-dihe-in -71.67, -13.58 -36.11, -59.51 APE12-dist-in 10.3189 APE11-dist-in 11.1833 APE10-dist-in 5.6098 APE9-dist-in 3.4626 None None None XRAY 2.06 0.229 0.274 A 282.0 265.0 0 26 26 0 [[133, 383]] 1.0 5g15 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2DWBA O14965 126 389 403.0 ANP:502 ATPlike Inactive DFGin 5.6048 15.1145 BLAminus -136.11, 177.41 60.85, 78.38 -89.15, 29.26 286.88, 68.88 -66.25, -4.03 in-in in 9.2398 Saltbr-in 3.1689 HRD-in -70.6, -46.07 60.68, 4.1 in-in-out SNCiio in-out ActLoopNT-in 3.0356 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -134.99, -178.03 APE9-dihe-na -132.27, -116.26 APE8-dihe-in -79.37, 134.9 APE8-rot-out 179.73 APE67-dihe-in -26.2, -44.84 -85.0, -15.78 APE12-dist-in 8.0361 APE11-dist-in 12.1391 APE10-dist-out 11.1616 APE9-dist-out 10.8267 None None MSE300,MSE305,MSE373 XRAY 2.5 0.227 0.275 A 285.0 262.0 2 26 24 2 [[133, 383]] 1.0 2dwb Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 6CPFA O14965 128 392 403.0 ACP:501 ATPlike Inactive DFGin 5.8515 16.0756 BLAminus -125.44, -173.01 51.86, 75.65 -92.36, 20.23 261.59, 77.98 -63.75, -18.06 out-none out 11.2478 Saltbr-none 999.0 HRD-in -104.84, -51.34 76.83, -36.49 none-in-out SNCnio in-out ActLoopNT-in 3.2019 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -168.9 APE8-dihe-in -78.28, 136.09 APE8-rot-out 59.9 APE67-dihe-in -54.01, -29.69 -75.21, 5.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7077 None None None XRAY 2.3 0.222 0.259 A 285.0 259.0 6 26 20 6 [[133, 383]] 1.0 6cpf Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5DRDA O14965 127 390 403.0 ATP:402 ATPlike Inactive DFGin 6.1794 15.4902 BLAminus -124.75, -173.07 54.37, 73.03 -91.89, 14.82 276.39, 76.92 -60.47, -27.86 in-in in 9.0942 Saltbr-in 2.7117 HRD-in -86.49, -50.72 75.89, 5.8 in-in-out SNCiio in-out ActLoopNT-in 3.0093 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -110.08 APE9-dihe-na -77.61, -136.85 APE8-dihe-in -63.84, 145.87 APE8-rot-out 199.39 APE67-dihe-in -52.56, -31.45 -96.52, -6.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.8473 APE9-dist-out 10.6226 T287A None None XRAY 2.13 0.209 0.262 A 273.0 259.0 5 26 21 5 [[133, 383]] 1.0 5drd Homo sapiens CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4DEEA O14965 124 394 403.0 ADP:503 ATPlike Inactive DFGin 5.9771 15.579 BLAminus -131.54, -177.86 61.33, 72.14 -88.35, 17.45 278.56, 69.2 -56.76, -24.29 in-in in 9.2363 Saltbr-in 2.8355 HRD-in -80.53, -51.88 66.61, 1.43 in-in-out SNCiio in-out ActLoopNT-in 2.6858 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -125.87, -53.37 APE9-dihe-na -86.66, -134.63 APE8-dihe-in -80.8, 152.73 APE8-rot-out 187.03 APE67-dihe-in -37.34, -40.8 -92.92, -9.81 APE12-dist-in 12.1076 APE11-dist-in 10.7866 APE10-dist-out 10.7625 APE9-dist-out 10.5323 T287D None None XRAY 2.3 0.213 0.259 A 279.0 271.0 0 26 26 0 [[133, 383]] 1.0 4dee Homo sapiens CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 6VPIA O14965 104 389 403.0 ANP:60601 ATPlike Inactive DFGin 5.4078 15.3189 BLAminus -130.78, 176.39 58.02, 80.51 -93.54, 25.65 284.58, 75.71 -64.44, -24.62 in-in in 9.8845 Saltbr-in 3.1969 HRD-in -68.95, -50.99 70.99, 3.21 in-in-out SNCiio in-out ActLoopNT-in 2.8207 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -142.04, 146.83 APE9-dihe-na 91.87, 167.2 APE8-dihe-in -74.18, 122.94 APE8-rot-in 319.25 APE67-dihe-in -55.59, -26.7 -100.93, -9.45 APE12-dist-in 10.0099 APE11-dist-in 12.8345 APE10-dist-out 16.1495 APE9-dist-out 20.0557 None None None XRAY 2.0 0.188 0.215 A 292.0 264.0 0 26 26 0 [[133, 383]] 1.0 6vpi Homo sapiens CAMK_AURKA_HUMAN CAMK 6.9e-78 267.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4CEGA O14965 127 391 403.0 ADP:1392 ATPlike Inactive DFGin 6.3211 15.6655 BLAminus -126.79, -176.42 60.85, 65.85 -88.73, 20.26 276.07, 70.68 -62.71, -30.16 in-in in 8.907 Saltbr-in 2.7521 HRD-in -80.9, -50.34 70.05, 0.74 in-in-out SNCiio in-out ActLoopNT-in 2.8816 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -88.79, -42.25 APE9-dihe-na -103.79, -144.9 APE8-dihe-in -67.83, 148.92 APE8-rot-out 184.96 APE67-dihe-in -49.78, -34.34 -90.88, -2.74 APE12-dist-in 12.0347 APE11-dist-in 10.9906 APE10-dist-out 11.5002 APE9-dist-out 10.933 C290A,C393A TPO288 TPO288 XRAY 2.1 0.202 0.237 A 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 4ceg Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 1OL6A O14965 128 388 403.0 ATP:1388 ATPlike Inactive DFGin 5.8513 15.6403 BLAminus -135.92, 178.5 52.45, 77.03 -92.23, 24.52 292.21, 75.73 -61.17, -14.48 in-out in 9.9117 Saltbr-out 4.6692 HRD-in -62.99, -55.9 71.29, 3.18 out-in-none SNCoin in-none ActLoopNT-in 3.0994 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.06 APE8-rot-in 336.17 APE67-dihe-in -65.51, -21.75 -47.85, -55.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D274N None None XRAY 3.0 0.277 0.301 A 282.0 246.0 15 26 15 11 [[133, 383]] 1.0 1ol6 Homo sapiens CAMK_AURKA_HUMAN CAMK 4.4e-79 271.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 6VPLA O14965 7 389 403.0 ANP:60602,R7D:60606 ATPlike,Allosteric Inactive DFGin 5.4712 15.7016 BLAminus -128.47, 179.47 64.6, 81.81 -95.02, 21.48 283.88, 78.68 -63.38, -17.61 out-out out 10.4098 Saltbr-out 4.4992 HRD-in -80.46, -54.34 74.63, 5.06 out-in-out SNCoio in-out ActLoopNT-in 2.9665 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -88.44, -6.25 APE9-dihe-na -62.06, -23.8 APE8-dihe-in -134.19, 108.37 APE8-rot-in 311.29 APE67-dihe-in -61.89, -28.27 -86.38, -9.29 APE12-dist-out 25.8944 APE11-dist-out 21.3249 APE10-dist-out 23.1598 APE9-dist-out 28.0042 None TPO288 TPO288 XRAY 1.86 0.169 0.201 A 292.0 262.0 4 26 22 4 [[133, 383]] 1.0 6vpl Homo sapiens CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 6VPLB O14965 7 389 403.0 ANP:60601,R7D:60605 ATPlike,Allosteric Inactive DFGin 5.5835 16.0448 BLAminus -127.84, 176.75 65.51, 80.18 -93.8, 23.88 286.09, 77.69 -67.93, -15.19 out-out out 10.6562 Saltbr-out 4.5577 HRD-in -79.97, -52.06 71.02, 4.97 out-in-out SNCoio in-out ActLoopNT-in 2.9438 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -84.27, -7.56 APE9-dihe-na -59.65, -24.89 APE8-dihe-in -135.15, 99.87 APE8-rot-in 315.26 APE67-dihe-in -58.26, -30.91 -76.18, -13.07 APE12-dist-out 25.8592 APE11-dist-out 21.4014 APE10-dist-out 23.5627 APE9-dist-out 28.2448 None TPO288 TPO288 XRAY 1.86 0.169 0.201 B 292.0 262.0 4 26 22 4 [[133, 383]] 1.0 6vpl Homo sapiens CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 6VPMA O14965 7 389 403.0 AMP:60602,R74:60603 ATPlike,Allosteric Inactive DFGin 5.5106 15.7854 BLAminus -126.3, 179.56 64.46, 79.19 -94.31, 22.45 283.25, 78.95 -62.44, -22.15 out-out out 10.4649 Saltbr-out 4.6318 HRD-in -82.12, -50.43 74.02, 3.7 out-in-out SNCoio in-out ActLoopNT-in 2.9505 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -94.21, -5.66 APE9-dihe-na -50.93, -40.67 APE8-dihe-in -122.63, 120.42 APE8-rot-out 167.52 APE67-dihe-in -61.47, -28.56 -78.55, -11.77 APE12-dist-out 25.8473 APE11-dist-out 21.3063 APE10-dist-out 23.1902 APE9-dist-out 28.0965 None TPO288 TPO288 XRAY 1.58 0.17 0.203 A 292.0 261.0 4 26 22 4 [[133, 383]] 1.0 6vpm Homo sapiens CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 6VPMB O14965 7 389 403.0 AMP:60601,R74:60602 ATPlike,Allosteric Inactive DFGin 5.618 16.1711 BLAminus -126.47, 179.26 64.24, 79.8 -93.68, 23.42 285.18, 79.92 -68.14, -17.47 out-out out 10.727 Saltbr-out 4.7852 HRD-in -77.29, -52.49 74.53, -0.08 out-in-out SNCoio in-out ActLoopNT-in 2.9546 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -95.93, -6.99 APE9-dihe-na -61.27, -34.46 APE8-dihe-in -116.01, 94.69 APE8-rot-in 318.22 APE67-dihe-in -54.76, -31.62 -74.36, -14.23 APE12-dist-out 26.0157 APE11-dist-out 21.5194 APE10-dist-out 23.6303 APE9-dist-out 28.4313 None TPO288 TPO288 XRAY 1.58 0.17 0.203 B 292.0 261.0 4 26 22 4 [[133, 383]] 1.0 6vpm Homo sapiens CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5ORLA O14965 127 391 403.0 ADP:401,A4W:407 ATPlike,Allosteric Inactive DFGin 7.0659 16.6489 BLAminus -127.84, -172.28 56.81, 60.19 -82.35, 15.9 271.2, 75.61 -63.85, -28.67 in-in in 9.0488 Saltbr-in 2.7502 HRD-in -78.27, -48.5 74.34, -1.48 in-in-out SNCiio in-out ActLoopNT-in 2.9772 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -99.11, -104.69 APE9-dihe-na -74.24, -110.44 APE8-dihe-in -76.15, 148.12 APE8-rot-out 189.45 APE67-dihe-in -56.74, -24.81 -85.95, -8.4 APE12-dist-in 12.0723 APE11-dist-in 10.971 APE10-dist-out 10.3882 APE9-dist-out 11.2888 C290A TPO288 TPO288 XRAY 1.69 0.206 0.238 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orl Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5ORNA O14965 127 391 403.0 ADP:401,A5E:404 ATPlike,Allosteric Inactive DFGin 5.6718 15.4032 BLAminus -130.34, -174.38 54.92, 79.97 -94.37, 17.54 279.26, 75.58 -55.07, -30.09 in-in in 9.3539 Saltbr-in 2.9285 HRD-in -81.32, -50.86 72.88, 0.4 in-in-out SNCiio in-out ActLoopNT-in 3.025 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -63.8, -59.63 APE9-dihe-na -97.49, -117.04 APE8-dihe-in -91.34, 143.03 APE8-rot-out 191.17 APE67-dihe-in -51.25, -26.05 -82.57, -15.54 APE12-dist-in 12.3855 APE11-dist-in 10.4017 APE10-dist-out 11.4938 APE9-dist-out 11.3568 None TPO288 TPO288 XRAY 2.19 0.203 0.262 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orn Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5OROA O14965 127 391 403.0 ADP:401,A5H:404 ATPlike,Allosteric Inactive DFGin 5.6776 15.3373 BLAminus -140.88, -178.26 60.46, 77.77 -94.07, 18.69 277.24, 76.82 -52.63, -39.97 in-in in 9.2726 Saltbr-in 3.0567 HRD-in -74.27, -52.41 74.24, -3.23 in-in-out SNCiio in-out ActLoopNT-in 2.8427 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -87.43, -63.56 APE9-dihe-na -103.72, -111.07 APE8-dihe-in -78.78, 141.92 APE8-rot-out 181.93 APE67-dihe-in -53.21, -24.39 -89.75, -10.63 APE12-dist-in 12.176 APE11-dist-in 10.5588 APE10-dist-out 11.0011 APE9-dist-out 11.5009 None TPO288 TPO288 XRAY 2.12 0.223 0.281 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5oro Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5ORPA O14965 127 391 403.0 ADP:401,A5K:404 ATPlike,Allosteric Inactive DFGin 5.8123 15.4919 BLAminus -139.84, -179.78 59.55, 79.52 -94.35, 18.72 278.85, 73.24 -45.22, -42.84 in-in in 9.3871 Saltbr-in 2.908 HRD-in -83.1, -49.94 72.65, -1.94 in-in-out SNCiio in-out ActLoopNT-in 3.0344 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -75.76, -64.68 APE9-dihe-na -107.0, -110.58 APE8-dihe-in -81.78, 136.28 APE8-rot-out 180.06 APE67-dihe-in -57.19, -28.31 -85.06, -6.26 APE12-dist-in 12.3511 APE11-dist-in 10.944 APE10-dist-out 10.7661 APE9-dist-out 11.3666 None TPO288 TPO288 XRAY 2.19 0.21 0.273 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orp Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5ORRA O14965 127 391 403.0 ADP:401,A5Q:404 ATPlike,Allosteric Inactive DFGin 5.6648 15.4968 BLAminus -133.78, -179.48 60.85, 73.72 -91.04, 29.58 281.03, 75.21 -67.99, -25.16 in-in in 9.4213 Saltbr-in 3.055 HRD-in -80.95, -50.87 71.36, -2.01 in-in-out SNCiio in-out ActLoopNT-in 3.0207 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -79.12, -78.89 APE9-dihe-na -94.43, -116.97 APE8-dihe-in -78.43, 147.39 APE8-rot-out 182.93 APE67-dihe-in -56.59, -23.94 -94.11, -3.91 APE12-dist-in 12.2613 APE11-dist-in 11.0201 APE10-dist-out 10.4273 APE9-dist-out 11.0664 None TPO288 TPO288 XRAY 2.09 0.202 0.256 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orr Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5ORSA O14965 127 391 403.0 ADP:401,A5W:404 ATPlike,Allosteric Inactive DFGin 5.9555 15.6826 BLAminus -133.47, -175.79 56.95, 73.99 -92.77, 17.89 276.34, 75.78 -60.0, -24.97 in-in in 9.1746 Saltbr-in 2.899 HRD-in -79.83, -50.16 70.98, -0.5 in-in-out SNCiio in-out ActLoopNT-in 3.0015 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -90.64, -79.2 APE9-dihe-na -92.74, -115.85 APE8-dihe-in -81.19, 144.15 APE8-rot-out 184.83 APE67-dihe-in -58.67, -28.41 -85.39, -4.34 APE12-dist-in 12.1926 APE11-dist-in 10.9556 APE10-dist-out 10.6259 APE9-dist-out 11.291 None TPO288 TPO288 XRAY 1.98 0.209 0.257 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5ors Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5ORTA O14965 127 391 403.0 ADP:401,A5Z:406 ATPlike,Allosteric Inactive DFGin 5.9989 15.7538 BLAminus -125.96, -170.73 54.43, 75.09 -90.85, 19.73 277.07, 68.86 -49.78, -34.73 in-in in 9.1957 Saltbr-in 3.0255 HRD-in -79.74, -50.38 68.95, 1.55 in-in-out SNCiio in-out ActLoopNT-in 3.0837 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -85.06, -64.36 APE9-dihe-na -96.27, -115.21 APE8-dihe-in -89.65, 146.92 APE8-rot-out 194.22 APE67-dihe-in -52.62, -22.53 -93.73, -12.57 APE12-dist-in 12.5307 APE11-dist-in 10.9187 APE10-dist-out 10.824 APE9-dist-out 11.0185 None TPO288 TPO288 XRAY 2.56 0.208 0.275 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5ort Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5ORVA O14965 127 391 403.0 ADP:401,A65:406 ATPlike,Allosteric Inactive DFGin 5.6645 15.44 BLAminus -136.16, -176.05 58.92, 71.82 -89.03, 22.25 278.38, 76.78 -63.69, -25.31 in-in in 9.2454 Saltbr-in 2.8863 HRD-in -82.57, -52.35 73.38, 1.05 in-in-out SNCiio in-out ActLoopNT-in 3.0056 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -75.39, -87.03 APE9-dihe-na -89.16, -112.46 APE8-dihe-in -77.62, 139.73 APE8-rot-out 181.74 APE67-dihe-in -57.59, -25.24 -84.67, -4.17 APE12-dist-in 12.3135 APE11-dist-in 10.8773 APE10-dist-out 10.4209 APE9-dist-out 11.2549 None TPO288 TPO288 XRAY 1.88 0.214 0.268 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orv Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5ORWA O14965 127 391 403.0 ADP:401,A6E:404 ATPlike,Allosteric Inactive DFGin 5.7064 15.413 BLAminus -131.01, -175.69 56.41, 78.46 -94.05, 21.38 277.67, 78.36 -59.98, -27.55 in-in in 9.316 Saltbr-in 3.0048 HRD-in -84.25, -51.01 70.55, 2.29 in-in-out SNCiio in-out ActLoopNT-in 3.0694 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -84.32, -59.08 APE9-dihe-na -102.85, -110.93 APE8-dihe-in -86.24, 134.05 APE8-rot-out 178.0 APE67-dihe-in -62.04, -25.17 -80.18, -4.89 APE12-dist-in 12.2689 APE11-dist-in 10.8105 APE10-dist-out 10.9798 APE9-dist-out 11.1995 None TPO288 TPO288 XRAY 2.0 0.217 0.27 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orw Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5ORXA O14965 127 391 403.0 ADP:401,A6H:404 ATPlike,Allosteric Inactive DFGin 5.4831 15.3325 BLAminus -135.37, -175.69 58.5, 74.51 -88.48, 21.31 281.01, 74.45 -55.7, -31.23 in-in in 9.3916 Saltbr-in 2.8871 HRD-in -84.87, -52.92 73.65, 2.44 in-in-out SNCiio in-out ActLoopNT-in 2.9566 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -81.41, -75.31 APE9-dihe-na -97.77, -112.93 APE8-dihe-in -77.56, 136.59 APE8-rot-out 185.81 APE67-dihe-in -60.3, -23.27 -81.45, -7.22 APE12-dist-in 12.2711 APE11-dist-in 10.9764 APE10-dist-out 10.2482 APE9-dist-out 10.9212 None TPO288 TPO288 XRAY 1.88 0.222 0.27 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orx Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5ORYA O14965 127 391 403.0 ADP:401,AY4:406 ATPlike,Allosteric Inactive DFGin 5.665 15.4321 BLAminus -133.35, -178.83 58.64, 81.27 -98.02, 26.99 280.05, 73.77 -66.34, -26.48 in-in in 9.4129 Saltbr-in 3.0153 HRD-in -83.1, -49.94 67.85, 0.8 in-in-out SNCiio in-out ActLoopNT-in 2.9683 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -85.35, -78.87 APE9-dihe-na -90.27, -119.1 APE8-dihe-in -76.79, 146.69 APE8-rot-out 180.58 APE67-dihe-in -53.43, -25.94 -95.91, -5.0 APE12-dist-in 12.4465 APE11-dist-in 11.0475 APE10-dist-out 10.7427 APE9-dist-out 11.1533 None TPO288 TPO288 XRAY 1.99 0.207 0.265 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5ory Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5ORZA O14965 127 391 403.0 ADP:401,A6W:407 ATPlike,Allosteric Inactive DFGin 5.6745 15.4067 BLAminus -135.57, -175.22 57.46, 80.66 -98.54, 24.2 276.77, 79.7 -65.5, -21.43 in-in in 9.2536 Saltbr-in 3.1111 HRD-in -80.39, -48.42 71.09, -2.39 in-in-out SNCiio in-out ActLoopNT-in 3.0623 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -82.59, -77.55 APE9-dihe-na -100.89, -113.21 APE8-dihe-in -76.47, 144.8 APE8-rot-out 177.65 APE67-dihe-in -57.19, -24.65 -94.21, -4.24 APE12-dist-in 12.3009 APE11-dist-in 10.8877 APE10-dist-out 10.4018 APE9-dist-out 11.2099 None TPO288 TPO288 XRAY 1.92 0.199 0.244 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orz Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5OS0A O14965 127 391 403.0 ADP:401,A6Z:404 ATPlike,Allosteric Inactive DFGin 5.6629 15.4407 BLAminus -133.76, -174.78 57.78, 75.99 -91.75, 21.09 277.99, 75.39 -60.35, -28.95 in-in in 9.311 Saltbr-in 2.7878 HRD-in -86.51, -49.56 71.53, 0.91 in-in-out SNCiio in-out ActLoopNT-in 2.9596 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -90.57, -76.63 APE9-dihe-na -103.27, -112.09 APE8-dihe-in -75.93, 143.74 APE8-rot-out 179.33 APE67-dihe-in -59.48, -25.37 -86.69, -3.69 APE12-dist-in 12.1557 APE11-dist-in 10.864 APE10-dist-out 10.2569 APE9-dist-out 11.2043 None TPO288 TPO288 XRAY 1.74 0.22 0.264 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5os0 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5OS1A O14965 127 391 403.0 ADP:401,A7H:407 ATPlike,Allosteric Inactive DFGin 5.601 15.3207 BLAminus -135.04, -179.66 61.87, 77.96 -95.19, 22.65 277.87, 73.62 -63.45, -26.73 in-in in 9.2237 Saltbr-in 2.9199 HRD-in -84.64, -47.57 66.67, 4.82 in-in-out SNCiio in-out ActLoopNT-in 3.0164 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -71.95, -77.41 APE9-dihe-na -100.69, -116.41 APE8-dihe-in -72.42, 138.52 APE8-rot-out 177.77 APE67-dihe-in -60.13, -26.29 -83.6, -2.57 APE12-dist-in 12.2392 APE11-dist-in 10.8166 APE10-dist-out 10.5993 APE9-dist-out 11.2579 None TPO288 TPO288 XRAY 1.9 0.203 0.25 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5os1 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5OS2A O14965 127 391 403.0 ADP:401,A7K:404 ATPlike,Allosteric Inactive DFGin 5.6983 15.5293 BLAminus -131.21, -175.25 58.7, 76.84 -90.56, 21.45 276.93, 76.69 -62.35, -9.35 in-in in 9.3094 Saltbr-in 2.9759 HRD-in -79.13, -51.53 72.78, 2.45 in-in-out SNCiio in-out ActLoopNT-in 3.0182 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -27.53 APE9-dihe-na -109.52, -133.64 APE8-dihe-in -78.79, 129.87 APE8-rot-out 174.59 APE67-dihe-in -60.88, -25.02 -78.66, -3.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.8302 APE9-dist-out 10.9565 None None None XRAY 1.92 0.213 0.251 A 265.0 261.0 4 26 22 4 [[133, 383]] 1.0 5os2 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5OS3A O14965 127 391 403.0 ADP:401,A7N:404 ATPlike,Allosteric Inactive DFGin 5.8534 15.6154 BLAminus -132.65, -178.67 63.71, 72.3 -91.21, 21.81 276.12, 75.45 -58.53, -29.86 in-in in 9.1686 Saltbr-in 2.9283 HRD-in -82.57, -48.69 69.82, -0.73 in-in-out SNCiio in-out ActLoopNT-in 2.9663 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -97.05, -71.52 APE9-dihe-na -103.15, -115.69 APE8-dihe-in -76.83, 145.54 APE8-rot-out 186.8 APE67-dihe-in -55.71, -28.81 -87.14, -3.16 APE12-dist-in 12.1833 APE11-dist-in 10.9495 APE10-dist-out 10.3755 APE9-dist-out 11.239 None TPO288 TPO288 XRAY 1.81 0.203 0.238 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5os3 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5OS4A O14965 127 391 403.0 ADP:401,A8H:404 ATPlike,Allosteric Inactive DFGin 5.5617 15.3883 BLAminus -130.51, -177.66 61.48, 75.55 -91.39, 22.5 279.03, 76.09 -60.73, -28.57 in-in in 9.2451 Saltbr-in 2.8621 HRD-in -82.71, -48.02 68.35, 3.92 in-in-out SNCiio in-out ActLoopNT-in 2.9591 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -77.92, -67.81 APE9-dihe-na -96.69, -121.48 APE8-dihe-in -75.57, 137.34 APE8-rot-out 180.49 APE67-dihe-in -57.86, -25.07 -81.82, -5.88 APE12-dist-in 12.2565 APE11-dist-in 10.8031 APE10-dist-out 10.9355 APE9-dist-out 11.2587 None TPO288 TPO288 XRAY 1.88 0.205 0.24 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5os4 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5OS6A O14965 127 391 403.0 ADP:401,A7Q:404 ATPlike,Allosteric Inactive DFGin 6.0291 15.7815 BLAminus -126.13, -169.53 51.73, 76.81 -92.36, 19.58 272.42, 79.82 -57.78, -34.45 in-in in 9.2445 Saltbr-in 2.995 HRD-in -81.41, -52.88 69.05, 4.37 in-in-out SNCiio in-out ActLoopNT-in 3.0404 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -77.03, -70.53 APE9-dihe-na -90.32, -115.88 APE8-dihe-in -84.85, 141.6 APE8-rot-out 180.13 APE67-dihe-in -64.32, -26.41 -86.27, 0.74 APE12-dist-in 12.2131 APE11-dist-in 10.8263 APE10-dist-out 10.7401 APE9-dist-out 10.9916 None TPO288 TPO288 XRAY 2.2 0.216 0.277 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5os6 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5OSEA O14965 127 391 403.0 ADP:401,A98:404 ATPlike,Allosteric Inactive DFGin 5.6464 15.4407 BLAminus -134.11, -176.47 59.39, 78.15 -96.43, 21.72 274.12, 77.75 -65.33, -24.45 in-in in 9.1368 Saltbr-in 2.8845 HRD-in -78.93, -49.87 70.59, 0.35 in-in-out SNCiio in-out ActLoopNT-in 2.9592 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -81.25, -72.54 APE9-dihe-na -105.09, -114.94 APE8-dihe-in -73.18, 141.65 APE8-rot-out 184.53 APE67-dihe-in -56.53, -26.26 -88.57, -5.48 APE12-dist-in 12.1504 APE11-dist-in 10.9758 APE10-dist-out 10.508 APE9-dist-out 11.2527 None TPO288 TPO288 XRAY 1.9 0.192 0.237 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5ose Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5OSFA O14965 127 391 403.0 ADP:401,A9E:404 ATPlike,Allosteric Inactive DFGin 5.7593 15.6562 BLAminus -131.88, -178.74 65.35, 71.33 -84.84, 21.28 278.92, 73.36 -65.0, -27.04 in-in in 9.3139 Saltbr-in 2.8266 HRD-in -85.08, -46.49 62.7, 8.17 in-in-out SNCiio in-out ActLoopNT-in 2.9651 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -87.68, -61.8 APE9-dihe-na -106.59, -110.06 APE8-dihe-in -85.81, 135.3 APE8-rot-out 180.39 APE67-dihe-in -56.65, -25.75 -79.56, -7.54 APE12-dist-in 12.2037 APE11-dist-in 10.6895 APE10-dist-out 10.9134 APE9-dist-out 11.4534 None TPO288 TPO288 XRAY 1.89 0.204 0.254 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5osf Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5OSDA O14965 125 391 403.0 ADP:401,A9B:404 ATPlike,Allosteric Inactive DFGin 5.672 15.4437 BLAminus -133.73, -178.01 59.76, 77.67 -95.6, 25.32 277.59, 73.38 -66.16, -23.93 in-in in 9.1535 Saltbr-in 2.9136 HRD-in -79.03, -50.3 71.01, -1.56 in-in-out SNCiio in-out ActLoopNT-in 3.0371 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -81.55, -62.64 APE9-dihe-na -107.55, -120.42 APE8-dihe-in -75.26, 143.45 APE8-rot-out 177.88 APE67-dihe-in -54.13, -27.04 -91.57, -4.8 APE12-dist-in 12.2502 APE11-dist-in 11.0743 APE10-dist-out 10.8059 APE9-dist-out 11.1972 None TPO288 TPO288 XRAY 1.99 0.198 0.239 A 267.0 267.0 0 26 26 0 [[133, 383]] 1.0 5osd Homo sapiens CAMK_AURKA_HUMAN CAMK 7.4e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5OS5A O14965 125 392 403.0 ADP:401,A8K:404 ATPlike,Allosteric Inactive DFGin 5.536 15.2749 BLAminus -135.35, -174.05 58.1, 79.63 -93.47, 22.72 276.13, 73.04 -64.31, -25.3 in-in in 9.3797 Saltbr-in 2.8681 HRD-in -80.2, -52.69 73.71, 2.64 in-in-out SNCiio in-out ActLoopNT-in 2.8801 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -96.33, -47.43 APE9-dihe-na -104.6, -130.88 APE8-dihe-in -73.88, 139.12 APE8-rot-out 187.09 APE67-dihe-in -61.32, -25.92 -83.14, -4.09 APE12-dist-in 12.2806 APE11-dist-in 10.8451 APE10-dist-out 11.3572 APE9-dist-out 10.9535 None TPO288 TPO288 XRAY 1.74 0.199 0.236 A 268.0 268.0 0 26 26 0 [[133, 383]] 1.0 5os5 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.5e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 6R49A O14965 127 391 403.0 ADP:501,JSB:504 ATPlike,Allosteric Inactive DFGin 5.6142 15.4571 BLAminus -138.43, -175.42 57.6, 78.22 -94.44, 21.89 276.25, 76.24 -57.77, -33.65 in-in in 9.3806 Saltbr-in 2.8938 HRD-in -87.16, -51.58 76.44, -3.34 in-in-out SNCiio in-out ActLoopNT-in 3.1015 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -122.85 APE8-dihe-in -81.14, 140.15 APE8-rot-out 187.07 APE67-dihe-in -51.76, -30.76 -84.84, -7.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0529 C290A,C393A TPO288 TPO288 XRAY 2.209 0.194 0.24 A 285.0 260.0 5 26 21 5 [[133, 383]] 1.0 6r49 Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 6R4AA O14965 127 391 403.0 ADP:501,JRT:510 ATPlike,Allosteric Inactive DFGin 6.1565 15.9493 BLAminus -128.43, -176.18 59.16, 64.31 -84.29, 19.22 274.78, 74.05 -63.59, -28.66 in-in in 9.1016 Saltbr-in 2.8252 HRD-in -85.32, -47.41 69.85, -3.89 in-in-out SNCiio in-out ActLoopNT-in 3.0232 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -103.23, -102.89 APE9-dihe-na -87.4, -108.97 APE8-dihe-in -74.29, 145.29 APE8-rot-out 184.87 APE67-dihe-in -57.97, -25.59 -89.08, -1.69 APE12-dist-in 12.109 APE11-dist-in 10.8679 APE10-dist-out 9.9425 APE9-dist-out 11.4483 C290A,C393A TPO288 TPO288 XRAY 1.937 0.193 0.234 A 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 6r4a Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 6R4BA O14965 127 391 403.0 ADP:501,JSN:508 ATPlike,Allosteric Inactive DFGin 5.8943 15.6634 BLAminus -137.57, -177.62 60.57, 72.93 -89.1, 20.04 274.87, 75.15 -57.71, -33.47 in-in in 9.285 Saltbr-in 2.8908 HRD-in -83.52, -48.93 71.64, -3.16 in-in-out SNCiio in-out ActLoopNT-in 2.9599 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -86.33, -81.37 APE9-dihe-na -105.19, -110.27 APE8-dihe-in -73.56, 134.57 APE8-rot-out 182.29 APE67-dihe-in -52.75, -29.28 -80.52, -6.55 APE12-dist-in 12.1859 APE11-dist-in 10.9551 APE10-dist-out 10.1562 APE9-dist-out 11.3762 None TPO288 TPO288 XRAY 2.15 0.191 0.23 A 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 6r4b Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 6R4CA O14965 127 391 403.0 ADP:501,JRQ:507 ATPlike,Allosteric Inactive DFGin 6.0205 15.666 BLAminus -134.91, -179.34 60.98, 67.5 -85.83, 17.59 275.41, 71.94 -60.31, -30.9 in-in in 9.0676 Saltbr-in 2.7695 HRD-in -80.73, -51.78 76.01, -7.95 in-in-out SNCiio in-out ActLoopNT-in 2.8911 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -93.37, -96.1 APE9-dihe-na -98.19, -111.55 APE8-dihe-in -67.65, 142.09 APE8-rot-out 185.03 APE67-dihe-in -56.49, -28.95 -89.55, -1.14 APE12-dist-in 12.1917 APE11-dist-in 10.8889 APE10-dist-out 9.9307 APE9-dist-out 11.3954 C290A,C393A TPO288 TPO288 XRAY 2.04 0.188 0.226 A 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 6r4c Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 6R4DA O14965 127 391 403.0 ADP:501,JRW:505 ATPlike,Allosteric Inactive DFGin 5.4128 15.0606 BLAminus -136.32, -175.95 60.26, 82.3 -97.39, 21.73 280.16, 71.96 -61.32, -30.02 in-in in 9.3772 Saltbr-in 2.9356 HRD-in -84.35, -49.77 70.9, 2.54 in-in-out SNCiio in-out ActLoopNT-in 2.8984 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -109.88, -49.72 APE9-dihe-na -75.41, -134.11 APE8-dihe-in -89.35, 144.76 APE8-rot-out 181.5 APE67-dihe-in -55.31, -28.98 -80.38, -7.16 APE12-dist-in 12.1691 APE11-dist-in 10.3905 APE10-dist-out 11.4777 APE9-dist-out 10.5886 C290A,C393A TPO288 TPO288 XRAY 2.009 0.197 0.233 A 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 6r4d Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 8OF5A O14965 126 390 403.0 ADP:501,MPO:505 ATPlike,Allosteric Inactive DFGin 5.5613 15.0734 BLAminus -147.6, 177.58 63.9, 71.93 -82.69, 26.74 280.62, 72.05 -50.28, -40.53 in-in in 9.3763 Saltbr-in 2.7388 HRD-in -82.42, -53.84 70.6, 7.86 in-in-out SNCiio in-out ActLoopNT-in 2.9866 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na 65.3, 47.54 APE9-dihe-na -68.67, -176.82 APE8-dihe-in -69.15, 145.4 APE8-rot-out 54.1 APE67-dihe-in -51.26, -26.94 -88.64, -16.45 APE12-dist-out 18.2387 APE11-dist-out 20.5865 APE10-dist-out 23.6119 APE9-dist-out 27.9049 C290A,N332A,Q335A,C393A None None XRAY 1.97 0.186 0.235 A 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 8of5 Homo sapiens CAMK_AURKA_HUMAN CAMK 3.1e-78 268.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 8C14A O14965 126 389 403.0 ADP:417,T5L:418,T0L:424 ATPlike,Allosteric,Allosteric Inactive DFGin 5.6307 14.7937 BLAminus -132.92, -178.64 59.29, 78.11 -87.91, 19.69 280.37, 75.08 -49.0, -40.94 in-in in 9.3228 Saltbr-in 2.7489 HRD-in -74.47, -52.26 68.72, 1.37 in-in-out SNCiio in-out ActLoopNT-in 2.8228 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -125.05, 2.89 APE9-dihe-na -76.04, 173.54 APE8-dihe-in -47.98, 133.45 APE8-rot-in 311.24 APE67-dihe-in -48.21, -32.08 -100.5, -9.07 APE12-dist-in 9.0819 APE11-dist-in 13.0305 APE10-dist-out 15.5933 APE9-dist-out 10.8925 None TPO288 TPO288 XRAY 1.93 0.182 0.194 A 272.0 264.0 0 26 26 0 [[133, 383]] 1.0 8c14 Homo sapiens CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 8C15A O14965 126 388 403.0 ADP:401,T4C:404,T5L:405 ATPlike,Allosteric,Allosteric Inactive DFGin 5.6579 14.941 BLAminus -128.39, 176.76 57.21, 80.94 -90.54, 19.4 280.16, 77.64 -46.89, -42.14 in-in in 9.3562 Saltbr-in 2.9117 HRD-in -70.87, -48.88 65.09, -5.38 in-in-out SNCiio in-out ActLoopNT-in 2.8481 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -170.75 APE8-dihe-in -66.3, 161.07 APE8-rot-out 73.39 APE67-dihe-in -37.43, -35.12 -85.37, -6.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.144 C290A None None XRAY 2.41 0.199 0.207 A 265.0 259.0 4 26 22 4 [[133, 383]] 1.0 8c15 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 8C1FA O14965 126 388 403.0 ADP:401,T5L:409,T2O:417 ATPlike,Allosteric,Allosteric Inactive DFGin 5.4716 14.6337 BLAminus -130.51, -175.69 56.68, 77.24 -89.7, 19.52 279.6, 79.65 -52.03, -32.93 in-in in 9.3024 Saltbr-in 2.8107 HRD-in -73.98, -48.91 69.8, -1.54 in-in-out SNCiio in-out ActLoopNT-in 2.8765 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -138.04 APE8-dihe-in -67.54, 164.12 APE8-rot-out 77.8 APE67-dihe-in -44.07, -35.33 -85.42, 0.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.5223 C290A None None XRAY 1.924 0.206 0.234 A 265.0 258.0 5 26 21 5 [[133, 383]] 1.0 8c1f Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 8C1IA O14965 126 388 403.0 ADP:401,T1L:404,T5L:405 ATPlike,Allosteric,Allosteric Inactive DFGin 5.5241 14.838 BLAminus -129.39, -179.52 57.08, 78.15 -89.88, 20.87 280.11, 76.95 -51.9, -37.66 in-in in 9.3549 Saltbr-in 2.9056 HRD-in -72.05, -49.31 67.09, -4.7 in-in-out SNCiio in-out ActLoopNT-in 2.8215 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -172.24 APE8-dihe-in -59.73, 161.33 APE8-rot-out 79.24 APE67-dihe-in -39.82, -36.32 -87.05, -1.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.3413 C290A None None XRAY 2.81 0.213 0.234 A 265.0 260.0 3 26 23 3 [[133, 383]] 1.0 8c1i Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5DN3A O14965 125 389 403.0 5DN:402,ATP:404 Allosteric,ATPlike Inactive DFGin 5.6992 15.0424 BLAminus -130.89, -174.42 55.28, 74.81 -88.98, 14.12 275.51, 75.93 -51.92, -35.15 in-in in 9.1659 Saltbr-in 2.7201 HRD-in -77.57, -53.05 71.13, 1.06 in-in-out SNCiio in-out ActLoopNT-in 2.9564 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -118.61, -13.13 APE9-dihe-na -74.86, -176.69 APE8-dihe-in -54.45, 125.21 APE8-rot-in 310.73 APE67-dihe-in -44.24, -34.14 -96.33, -16.24 APE12-dist-in 9.4351 APE11-dist-in 13.2348 APE10-dist-out 15.6674 APE9-dist-out 11.2317 None TPO288 TPO288 XRAY 2.05 0.192 0.203 A 272.0 265.0 0 26 26 0 [[133, 383]] 1.0 5dn3 Homo sapiens CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 8C1EA O14965 127 388 403.0 T0X:401,ATP:403 Allosteric,ATPlike Inactive DFGin 5.7981 14.8074 BLAminus -150.0, 179.01 57.43, 76.53 -96.95, 20.99 278.49, 67.97 -56.09, -34.21 in-in in 9.1906 Saltbr-in 2.8469 HRD-in -74.81, -56.51 74.42, -5.07 in-in-out SNCiio in-out ActLoopNT-in 2.6152 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -165.45, 99.75 APE9-dihe-na -118.34, -95.63 APE8-dihe-in -111.54, 127.78 APE8-rot-in 354.95 APE67-dihe-in -38.77, -37.51 -96.45, -21.24 APE12-dist-in 9.259 APE11-dist-in 13.5443 APE10-dist-out 15.2592 APE9-dist-out 10.8956 None TPO288 TPO288 XRAY 2.798 0.176 0.239 A 272.0 262.0 0 26 26 0 [[133, 383]] 1.0 8c1e Homo sapiens CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5DT4A O14965 127 390 403.0 5DN:402,ATP:403 Allosteric,ATPlike Inactive DFGin 6.0226 15.016 BLAminus -131.6, -179.1 56.58, 87.02 -103.91, 25.71 282.11, 78.42 -59.32, -42.3 in-in in 9.5441 Saltbr-in 3.0038 HRD-in -66.18, -52.21 66.74, -14.36 in-in-out SNCiio in-out ActLoopNT-in 2.9439 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -57.69 APE9-dihe-na -89.02, -152.47 APE8-dihe-in -67.56, 141.58 APE8-rot-out 191.42 APE67-dihe-in -59.88, -41.29 -85.27, 2.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.1589 APE9-dist-out 9.9725 None None None XRAY 2.86 0.193 0.256 A 273.0 259.0 5 26 21 5 [[133, 383]] 1.0 5dt4 Homo sapiens CAMK_AURKA_HUMAN CAMK 6.5e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 8C1MA O14965 127 389 403.0 T4X:402,ADP:404 Allosteric,ATPlike Inactive DFGin 5.6001 15.2723 BLAminus -122.0, 174.82 64.71, 68.72 -82.42, 30.82 279.23, 73.39 -59.87, -38.7 in-in in 9.6473 Saltbr-in 3.0527 HRD-in -66.75, -51.37 63.02, 9.93 in-in-out SNCiio in-out ActLoopNT-in 2.8953 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -144.61, 52.2 APE9-dihe-na -98.47, -158.53 APE8-dihe-in -77.97, 114.41 APE8-rot-out 83.32 APE67-dihe-in -36.94, -36.23 -77.28, -23.95 APE12-dist-in 9.5276 APE11-dist-in 12.9895 APE10-dist-out 15.7549 APE9-dist-out 10.6188 None TPO288 TPO288 XRAY 2.84 0.253 0.269 A 273.0 263.0 0 26 26 0 [[133, 383]] 1.0 8c1m Homo sapiens CAMK_AURKA_HUMAN CAMK 6.5e-80 274.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5DOSA O14965 127 390 403.0 5DN:402,ATP:403 Allosteric,ATPlike Inactive DFGin 5.9 15.0444 BLAminus -141.11, -178.41 56.44, 85.64 -101.51, 29.55 282.61, 75.97 -61.45, -42.65 in-in in 9.4934 Saltbr-in 2.8607 HRD-in -75.29, -42.25 59.65, -8.83 in-in-out SNCiio in-out ActLoopNT-in 3.0424 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -79.83 APE9-dihe-na -91.08, -144.18 APE8-dihe-in -65.26, 123.97 APE8-rot-out 190.75 APE67-dihe-in -25.49, -64.25 -63.86, -31.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.0331 APE9-dist-out 9.7933 T287A None None XRAY 2.98 0.201 0.273 A 273.0 259.0 5 26 21 5 [[133, 383]] 1.0 5dos Homo sapiens CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5DR2A O14965 128 390 403.0 5E1:60401,ATP:60403 Allosteric,ATPlike Inactive DFGin 5.7419 15.1483 BLAminus -112.74, -178.24 59.1, 85.93 -103.74, 31.08 282.48, 80.94 -64.76, -39.96 in-in in 9.2247 Saltbr-in 2.8451 HRD-in -83.01, -54.44 78.2, -2.4 in-in-out SNCiio in-out ActLoopNT-in 2.8713 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -117.43, 59.62 APE9-dihe-na -131.57, -163.05 APE8-dihe-in -74.95, 143.42 APE8-rot-out 161.96 APE67-dihe-in -60.88, -32.64 -91.05, 11.96 APE12-dist-in 12.5259 APE11-dist-in 9.1209 APE10-dist-out 12.6318 APE9-dist-out 10.0391 T287A None None XRAY 2.46 0.225 0.285 A 273.0 263.0 0 26 26 0 [[133, 383]] 1.0 5dr2 Homo sapiens CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 8C1DA O14965 127 388 403.0 T2F:401,ADP:402,T5L:405 Allosteric,ATPlike,Allosteric Inactive DFGin 5.5903 14.7701 BLAminus -129.39, 179.64 57.3, 80.97 -92.88, 23.53 280.13, 79.47 -56.16, -33.44 in-in in 9.3061 Saltbr-in 2.9364 HRD-in -72.1, -50.49 67.69, -1.24 in-in-out SNCiio in-out ActLoopNT-in 2.7964 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 144.85 APE8-dihe-in -64.26, 154.27 APE8-rot-out 88.6 APE67-dihe-in -39.49, -36.75 -82.32, -6.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.088 C290A None None XRAY 2.115 0.212 0.238 A 265.0 259.0 3 26 23 3 [[133, 383]] 1.0 8c1d Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 8C1GA O14965 127 388 403.0 T3I:401,ADP:402,T5L:406 Allosteric,ATPlike,Allosteric Inactive DFGin 5.5437 14.882 BLAminus -128.11, -179.39 58.87, 76.11 -85.79, 22.41 279.68, 78.85 -51.87, -42.67 in-in in 9.2229 Saltbr-in 2.92 HRD-in -78.13, -46.93 64.28, -1.01 in-in-out SNCiio in-out ActLoopNT-in 2.8594 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -158.88 APE8-dihe-in -70.7, 159.97 APE8-rot-out 74.34 APE67-dihe-in -36.07, -37.71 -84.84, -3.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.3547 C290A None None XRAY 1.96 0.2 0.225 A 265.0 258.0 4 26 22 4 [[133, 383]] 1.0 8c1g Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 8C1HA O14965 127 388 403.0 T3U:401,ADP:402,T5L:405 Allosteric,ATPlike,Allosteric Inactive DFGin 5.6033 14.806 BLAminus -133.2, 171.3 67.89, 80.13 -90.96, 20.95 279.09, 80.15 -47.86, -43.49 in-in in 9.2738 Saltbr-in 3.0016 HRD-in -69.34, -50.65 67.03, -6.54 in-in-out SNCiio in-out ActLoopNT-in 2.8653 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -157.54 APE8-dihe-in -70.83, 158.42 APE8-rot-out 74.14 APE67-dihe-in -36.91, -39.82 -81.98, -5.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.5277 C290A None None XRAY 2.233 0.213 0.245 A 265.0 258.0 4 26 22 4 [[133, 383]] 1.0 8c1h Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 8C1KA O14965 127 388 403.0 T4O:401,ADP:402,T5L:405 Allosteric,ATPlike,Allosteric Inactive DFGin 5.3967 14.7974 BLAminus -136.92, -175.3 58.28, 79.92 -93.28, 13.0 269.57, 89.35 -50.4, -38.71 in-in in 9.6032 Saltbr-in 3.1142 HRD-in -64.38, -56.58 69.39, -9.24 in-in-out SNCiio in-out ActLoopNT-in 3.0088 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 39.31, -114.48 APE9-dihe-na 117.85, -67.49 APE8-dihe-in -136.08, 128.66 APE8-rot-out 19.12 APE67-dihe-in -37.03, -29.23 -73.31, -14.52 APE12-dist-in 9.2582 APE11-dist-in 12.9138 APE10-dist-out 12.6881 APE9-dist-out 10.8352 C290A None None XRAY 2.43 0.219 0.242 A 273.0 262.0 0 26 26 0 [[133, 383]] 1.0 8c1k Homo sapiens CAMK_AURKA_HUMAN CAMK 8e-79 270.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 8SSPA O14965 126 389 403.0 PDO:507,627:510 Allosteric,Type1 Inactive DFGin 5.8271 16.0973 BLAminus -128.28, -176.57 55.06, 88.12 -104.67, 28.54 279.82, 74.62 -68.31, -32.7 out-out out 10.4075 Saltbr-out 5.1218 HRD-in -77.88, -49.99 65.51, 20.52 out-in-in SNCoii in-in ActLoopNT-in 2.9682 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.81, 156.13 APE9-dihe-na 124.75, -152.05 APE8-dihe-in -113.82, 146.04 APE8-rot-in 319.01 APE67-dihe-in -74.25, -9.45 -51.04, -52.82 APE12-dist-in 10.2144 APE11-dist-in 11.1637 APE10-dist-in 5.5695 APE9-dist-in 3.5982 None None None XRAY 2.6 0.202 0.257 A 284.0 264.0 0 26 26 0 [[133, 383]] 1.0 8ssp Homo sapiens CAMK_AURKA_HUMAN CAMK 7.6e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 6CPEA O14965 127 389 403.0 No_ligand No_ligand Inactive DFGin 5.8487 15.4403 BLAminus -129.83, -177.34 58.21, 74.96 -91.4, 25.99 287.47, 70.66 -51.13, -60.41 in-in in 9.4954 Saltbr-in 2.6354 HRD-in -74.98, -53.23 69.96, 5.5 in-in-out SNCiio in-out ActLoopNT-in 3.0171 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -168.54 APE8-rot-out 73.87 APE67-dihe-in -48.92, -35.31 -91.44, -3.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.45 0.218 0.254 A 285.0 256.0 7 26 19 7 [[133, 383]] 1.0 6cpe Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4J8NA O14965 125 390 403.0 No_ligand No_ligand Inactive DFGin 5.9253 16.1592 BLAminus -129.5, -176.93 54.9, 81.06 -100.42, 18.24 277.9, 77.09 -55.57, -42.6 in-in in 9.6503 Saltbr-in 3.0411 HRD-in -71.66, -48.7 72.48, -23.07 in-in-out SNCiio in-out ActLoopNT-in 3.0709 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioo APE10-dihe-na -108.65, -134.85 APE9-dihe-na 51.07, -90.35 APE8-dihe-out 166.34, 127.33 APE8-rot-out 177.69 APE67-dihe-out -103.98, -33.6 -75.82, 64.16 APE12-dist-in 11.4112 APE11-dist-in 11.2704 APE10-dist-out 11.1537 APE9-dist-out 10.413 None None None XRAY 3.135 0.188 0.234 A 279.0 266.0 0 26 26 0 [[133, 383]] 1.0 4j8n Homo sapiens CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4J8NB O14965 125 390 403.0 No_ligand No_ligand Inactive DFGin 5.9082 16.2093 BLAminus -129.59, -174.78 53.22, 81.35 -99.27, 18.15 277.26, 76.69 -54.47, -45.17 in-in in 9.7192 Saltbr-in 3.006 HRD-in -72.1, -48.2 71.96, -19.42 in-in-out SNCiio in-out ActLoopNT-in 3.1111 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -94.27, -131.7 APE9-dihe-na 72.09, -72.86 APE8-dihe-out 115.97, 127.78 APE8-rot-out 202.98 APE67-dihe-in -54.47, -40.45 -100.94, 29.6 APE12-dist-in 11.4087 APE11-dist-in 11.0348 APE10-dist-out 10.938 APE9-dist-out 9.9423 None None None XRAY 3.135 0.188 0.234 B 279.0 266.0 0 26 26 0 [[133, 383]] 1.0 4j8n Homo sapiens CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4J8NC O14965 125 390 403.0 No_ligand No_ligand Inactive DFGin 5.93 16.2969 BLAminus -130.96, -172.88 51.49, 76.65 -93.62, 21.08 277.44, 74.97 -50.35, -43.64 in-in in 9.7588 Saltbr-in 3.1568 HRD-in -75.43, -46.61 71.17, -20.57 in-in-out SNCiio in-out ActLoopNT-in 3.1709 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -100.15, -18.01 APE9-dihe-na -95.51, 167.33 APE8-dihe-in -58.1, 137.58 APE8-rot-out 194.0 APE67-dihe-in -58.5, -42.08 -97.99, 30.31 APE12-dist-in 11.516 APE11-dist-in 11.236 APE10-dist-out 11.0009 APE9-dist-out 9.9942 None None None XRAY 3.135 0.188 0.234 C 279.0 266.0 0 26 26 0 [[133, 383]] 1.0 4j8n Homo sapiens CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4J8ND O14965 126 390 403.0 No_ligand No_ligand Inactive DFGin 5.9704 16.2752 BLAminus -130.78, -174.78 51.83, 76.2 -93.32, 22.06 277.06, 75.74 -52.13, -43.63 in-in in 9.6704 Saltbr-in 3.1674 HRD-in -75.14, -47.48 71.69, -20.75 in-in-out SNCiio in-out ActLoopNT-in 3.0974 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -97.15, -26.99 APE9-dihe-na -90.54, 167.49 APE8-dihe-in -56.97, 140.7 APE8-rot-out 192.37 APE67-dihe-in -54.7, -36.7 -101.24, 28.7 APE12-dist-in 11.4427 APE11-dist-in 11.1882 APE10-dist-out 11.1015 APE9-dist-out 10.1571 None None None XRAY 3.135 0.188 0.234 D 279.0 265.0 0 26 26 0 [[133, 383]] 1.0 4j8n Homo sapiens CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 8JG8A O14965 127 389 403.0 C74:401 Type1 Inactive DFGin 5.933 15.8241 BLAminus -128.49, 174.99 59.88, 99.05 -108.87, 38.26 286.14, 82.22 -57.46, -43.7 out-out out 11.9975 Saltbr-out 6.1676 HRD-in -95.62, -54.63 73.57, -39.54 out-in-out SNCoio in-out ActLoopNT-in 2.9683 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 127.44 APE9-dihe-na -110.98, -144.43 APE8-dihe-in -54.82, 132.81 APE8-rot-out 40.07 APE67-dihe-in -46.54, -36.9 -94.8, -4.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.1933 APE9-dist-out 11.4335 None None None XRAY 2.9 0.24 0.27 A 263.0 254.0 9 26 18 8 [[133, 383]] 1.0 8jg8 Homo sapiens CAMK_AURKA_HUMAN CAMK 5.7e-80 274.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3HA6A O14965 125 388 403.0 2JZ:60001 Type1 Inactive DFGin 5.6459 15.6001 BLAminus -141.58, -150.58 44.95, 71.07 -95.98, 24.45 275.33, 82.1 -69.8, -23.79 in-out in 9.8233 Saltbr-out 5.1728 HRD-in -80.25, -46.58 72.24, 2.41 out-in-in SNCoii in-in ActLoopNT-in 2.9331 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.19, 168.57 APE9-dihe-na 119.45, -143.59 APE8-dihe-in -142.6, 136.84 APE8-rot-in 301.05 APE67-dihe-in -73.19, -14.37 -23.68, -69.02 APE12-dist-in 7.8833 APE11-dist-in 11.0719 APE10-dist-in 5.4982 APE9-dist-in 3.5229 None TPO287,TPO288 TPO287,TPO288 XRAY 2.36 0.225 0.252 A 268.0 264.0 0 26 26 0 [[133, 383]] 1.0 3ha6 Homo sapiens CAMK_AURKA_HUMAN CAMK 6.1e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3VAPA O14965 127 388 403.0 0FY:1 Type1 Inactive DFGin 7.0112 16.5649 BLAminus -124.23, 172.43 53.89, 74.52 -90.45, 3.76 278.46, 77.35 -61.19, -14.68 in-in in 9.3773 Saltbr-in 2.8664 HRD-in -70.63, -46.43 60.81, 3.63 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 139.0 APE8-dihe-in -69.08, 141.35 APE8-rot-out 192.77 APE67-dihe-in -34.3, -47.94 -84.11, -19.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.0909 None None None XRAY 2.66 0.205 0.246 A 272.0 249.0 13 26 13 13 [[133, 383]] 1.0 3vap Homo sapiens CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2W1CA O14965 127 389 403.0 L0C:61391 Type1 Inactive DFGin 5.8817 15.7724 BLAminus -97.54, -171.65 46.97, 95.02 -107.87, 39.71 281.94, 64.97 -60.69, -63.22 out-out out 10.0089 Saltbr-out 4.9609 HRD-in -80.1, -60.42 81.68, -30.47 out-in-out SNCoio in-out ActLoopNT-in 2.6291 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -60.97, 82.12 APE9-dihe-na -172.55, 143.93 APE8-dihe-in -52.57, 121.38 APE8-rot-out 184.61 APE67-dihe-in -46.28, -28.66 -83.22, -14.63 APE12-dist-in 11.6996 APE11-dist-out 14.9012 APE10-dist-out 14.0995 APE9-dist-out 10.7258 None TPO287,TPO288 TPO287,TPO288 XRAY 3.24 0.246 0.288 A 275.0 263.0 0 26 26 0 [[133, 383]] 1.0 2w1c Homo sapiens CAMK_AURKA_HUMAN CAMK 6.7e-80 274.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2W1DA O14965 127 389 403.0 L0D:61391 Type1 Inactive DFGin 5.6701 15.6371 BLAminus -98.71, 177.07 59.81, 110.8 -129.83, 40.36 283.05, 72.78 -60.79, -58.22 in-out in 9.7057 Saltbr-out 4.7121 HRD-in -85.97, -78.13 96.93, -30.07 out-in-out SNCoio in-out ActLoopNT-in 2.8117 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 157.63 APE8-dihe-in -55.14, 99.56 APE8-rot-out 187.42 APE67-dihe-in -48.58, -23.35 -66.04, -18.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.1651 None None None XRAY 2.97 0.241 0.308 A 275.0 251.0 12 26 15 11 [[133, 383]] 1.0 2w1d Homo sapiens CAMK_AURKA_HUMAN CAMK 6.7e-80 274.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2W1EA O14965 127 389 403.0 L0E:61390 Type1 Inactive DFGin 5.3343 15.2815 BLAminus -88.39, 176.43 54.42, 134.09 -145.65, 35.35 288.57, 71.15 -59.93, -38.53 out-out out 10.0778 Saltbr-out 4.8837 HRD-in -93.32, -52.74 80.56, -19.82 out-in-out SNCoio in-out ActLoopNT-in 2.7346 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 153.28 APE8-dihe-in -60.09, 131.73 APE8-rot-out 186.14 APE67-dihe-in -42.44, -28.83 -84.72, -20.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.4643 None None None XRAY 2.93 0.237 0.302 A 275.0 252.0 11 26 15 11 [[133, 383]] 1.0 2w1e Homo sapiens CAMK_AURKA_HUMAN CAMK 6.7e-80 274.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2W1FA O14965 127 389 403.0 L0F:61390 Type1 Inactive DFGin 5.6549 15.7027 BLAminus -96.26, 172.45 62.06, 107.69 -118.91, 38.89 289.12, 66.42 -59.62, -48.4 out-out out 10.1385 Saltbr-out 5.1197 HRD-in -78.79, -54.88 78.03, -25.41 out-in-out SNCoio in-out ActLoopNT-in 2.6762 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -157.03 APE8-dihe-in -58.47, 105.92 APE8-rot-out 190.33 APE67-dihe-in -42.4, -27.58 -64.36, -20.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7745 None None None XRAY 2.85 0.246 0.348 A 275.0 253.0 10 26 16 10 [[133, 383]] 1.0 2w1f Homo sapiens CAMK_AURKA_HUMAN CAMK 6.7e-80 274.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2W1GA O14965 127 389 403.0 L0G:61390 Type1 Inactive DFGin 5.7066 15.9532 BLAminus -102.36, -172.29 37.95, 92.18 -96.86, 32.84 280.6, 71.33 -53.02, -62.72 in-out in 9.8021 Saltbr-out 4.5733 HRD-in -76.37, -58.52 85.2, -46.3 out-in-out SNCoio in-out ActLoopNT-in 2.7065 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 171.28 APE8-dihe-in -49.55, 126.01 APE8-rot-out 191.62 APE67-dihe-in -58.12, -27.65 -91.48, -7.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.4433 None TPO287,TPO288 TPO287,TPO288 XRAY 2.71 0.229 0.297 A 275.0 254.0 9 26 17 9 [[133, 383]] 1.0 2w1g Homo sapiens CAMK_AURKA_HUMAN CAMK 6.7e-80 274.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5ZANA O14965 127 389 403.0 9A6:501 Type1 Inactive DFGin 5.9215 15.7552 BLAminus -92.99, 175.48 46.37, 87.77 -88.95, 50.65 283.16, 69.59 -62.46, -35.37 out-none out 10.6249 Saltbr-none 999.0 HRD-in -84.0, -47.07 74.85, -53.4 none-in-out SNCnio in-out ActLoopNT-in 2.8869 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -158.12 APE8-dihe-in -77.87, 151.9 APE8-rot-out 71.81 APE67-dihe-in -45.51, -33.68 -101.83, 2.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1205 None None None XRAY 2.85 0.256 0.281 A 281.0 258.0 5 26 21 5 [[133, 383]] 1.0 5zan Homo sapiens CAMK_AURKA_HUMAN CAMK 7.3e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4O0SA O14965 126 391 403.0 ADN:500 Type1 Inactive DFGin 6.0576 16.5586 BLAminus -149.62, -178.05 57.82, 65.99 -83.76, 4.5 260.08, 87.32 -48.25, -52.63 out-out out 10.5115 Saltbr-out 4.1117 HRD-in -67.13, -53.86 77.45, -15.34 out-in-out SNCoio in-out ActLoopNT-in 2.9445 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -80.39, -35.33 APE9-dihe-na -145.46, 176.17 APE8-dihe-in -59.32, 141.88 APE8-rot-out 196.74 APE67-dihe-in -51.21, -41.15 -95.86, -1.7 APE12-dist-in 12.4771 APE11-dist-in 13.4802 APE10-dist-out 10.7317 APE9-dist-out 11.0274 None None None XRAY 2.5 0.238 0.25 A 282.0 265.0 1 26 25 1 [[133, 383]] 1.0 4o0s Homo sapiens CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2XNGA O14965 127 390 403.0 A0H:1391 Type1 Inactive DFGin 5.4826 15.5926 BLAminus -120.46, 176.57 56.36, 70.43 -73.62, 38.13 281.39, 65.5 -44.8, -64.31 in-out in 9.9179 Saltbr-out 4.1567 HRD-in -72.76, -59.76 78.84, -21.18 out-in-none SNCoin in-none ActLoopNT-in 3.1002 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -31.34 APE8-rot-in 245.35 APE67-dihe-in -47.83, -38.92 -81.58, -10.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.605 0.224 0.271 A 283.0 254.0 10 26 16 10 [[133, 383]] 1.0 2xng Homo sapiens CAMK_AURKA_HUMAN CAMK 7.5e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4JAJA O14965 125 389 403.0 XU1:900 Type1 Inactive DFGin 5.7863 15.2661 BLAminus -130.79, -179.22 60.79, 74.26 -92.96, 19.38 279.35, 69.28 -57.12, -30.9 in-in in 9.3292 Saltbr-in 3.5366 HRD-in -77.96, -53.2 74.51, -4.28 in-in-out SNCiio in-out ActLoopNT-in 2.9018 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -121.8, 178.09 APE9-dihe-na -147.27, -129.97 APE8-dihe-in -58.84, 128.06 APE8-rot-out 191.16 APE67-dihe-in -49.67, -35.58 -96.31, -4.37 APE12-dist-in 11.235 APE11-dist-in 12.4446 APE10-dist-out 11.4822 APE9-dist-out 10.8381 None None None XRAY 2.7 0.238 0.323 A 284.0 265.0 0 26 26 0 [[133, 383]] 1.0 4jaj Homo sapiens CAMK_AURKA_HUMAN CAMK 7.6e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2X6DA O14965 126 388 403.0 X6D:1391 Type1 Inactive DFGin 5.9409 15.0877 BLAminus -133.34, 178.89 66.11, 63.22 -78.84, 41.16 290.11, 72.3 -67.23, -32.17 in-out in 9.7614 Saltbr-out 3.7055 HRD-in -67.43, -47.15 74.62, -4.79 out-in-out SNCoio in-out ActLoopNT-in 2.9537 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -30.7 APE9-dihe-na 132.04, 170.08 APE8-dihe-in -58.22, 141.84 APE8-rot-out 194.18 APE67-dihe-in -56.15, -39.96 -97.87, -10.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.8166 APE9-dist-out 10.3813 None None None XRAY 2.796 0.22 0.264 A 285.0 255.0 8 26 22 4 [[133, 383]] 1.0 2x6d Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2X6EA O14965 126 388 403.0 YM4:1389 Type1 Inactive DFGin 5.3479 14.229 BLAminus -133.54, -165.49 47.01, 97.41 -106.94, 55.35 290.48, 60.79 -55.55, -43.91 in-out in 9.6199 Saltbr-out 3.9324 HRD-in -76.72, -65.71 73.76, 16.48 out-in-out SNCoio in-out ActLoopNT-in 2.9886 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 133.39 APE8-rot-out 167.74 APE67-dihe-in -39.2, -32.78 -108.28, -16.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.35 0.231 0.299 A 285.0 249.0 14 26 15 11 [[133, 383]] 1.0 2x6e Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4ZS0A O14965 127 388 403.0 4QV:501 Type1 Inactive DFGin 5.7775 15.3382 BLAminus -135.77, -170.35 51.72, 73.89 -87.94, 25.14 280.59, 69.39 -52.43, -36.14 out-out out 10.0384 Saltbr-out 4.0538 HRD-in -78.33, -50.96 66.12, -1.97 out-in-none SNCoin in-none ActLoopNT-in 2.8481 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 56.86 APE8-rot-in 353.63 APE67-dihe-in -54.02, -31.18 -108.57, -3.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.205 0.251 A 285.0 257.0 5 26 21 5 [[133, 383]] 1.0 4zs0 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 6I2UA O14965 127 391 403.0 COA:501 Type1 Inactive DFGin 5.5262 14.9893 BLAminus -140.44, 177.56 64.83, 76.33 -90.26, 27.46 278.08, 68.91 -57.42, -31.8 in-in in 9.1646 Saltbr-in 2.9821 HRD-in -75.81, -51.2 63.39, 7.96 in-in-out SNCiio in-out ActLoopNT-in 2.9162 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -63.93, -34.08 APE9-dihe-na -96.67, -156.35 APE8-dihe-in -64.78, 150.87 APE8-rot-out 178.16 APE67-dihe-in -46.91, -34.21 -90.55, -4.34 APE12-dist-in 11.8012 APE11-dist-in 10.3 APE10-dist-out 11.1914 APE9-dist-out 10.2286 None TPO287,TPO288 TPO287,TPO288 XRAY 2.5 0.207 0.252 A 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 6i2u Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2XRUA O14965 126 389 403.0 400:1389 Type1 Inactive DFGin 6.1494 15.6457 BLAminus -125.16, 155.4 69.4, 129.42 -125.84, -55.47 276.35, 73.58 -8.05, 69.57 in-out in 9.97 Saltbr-out 4.3638 HRD-in -88.84, -45.6 72.75, -79.27 out-in-out SNCoio in-out ActLoopNT-in 2.9362 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 173.9 APE9-dihe-na 96.75, -152.28 APE8-dihe-in -102.76, 132.26 APE8-rot-in 267.24 APE67-dihe-in -30.79, -36.85 -72.99, -23.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.2081 APE9-dist-out 12.1191 T288E None None XRAY 2.9 0.247 0.344 A 280.0 254.0 10 26 16 10 [[133, 383]] 1.0 2xru Homo sapiens CAMK_AURKA_HUMAN CAMK 1.7e-79 272.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3UO4A O14965 124 389 403.0 0C0:1 Type1 Inactive DFGin 6.2315 16.3784 BLAminus -126.04, -172.68 53.05, 69.73 -90.42, 6.21 269.6, 80.64 -48.08, -48.65 out-out out 10.0827 Saltbr-out 3.6201 HRD-in -70.53, -55.35 72.71, -18.06 out-in-out SNCoio in-out ActLoopNT-in 2.9804 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -118.54, -77.7 APE9-dihe-na -66.0, 113.52 APE8-dihe-out 41.71, -150.3 APE8-rot-in 344.62 APE67-dihe-in -48.42, -37.12 -114.97, -5.05 APE12-dist-in 11.8382 APE11-dist-in 10.7213 APE10-dist-out 10.0956 APE9-dist-out 9.2219 T287D None None XRAY 2.45 0.22 0.257 A 279.0 266.0 0 26 26 0 [[133, 383]] 1.0 3uo4 Homo sapiens CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3UO5A O14965 124 390 403.0 0BX:501 Type1 Inactive DFGin 5.7654 15.6342 BLAminus -112.49, -174.84 56.04, 76.01 -85.73, 17.59 274.77, 67.57 -44.32, -44.34 in-out in 9.8969 Saltbr-out 4.1143 HRD-in -75.88, -52.17 75.0, -19.1 out-in-out SNCoio in-out ActLoopNT-in 2.7873 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -81.4, -63.65 APE9-dihe-na -91.09, -150.37 APE8-dihe-in -65.51, 136.03 APE8-rot-out 189.54 APE67-dihe-in -47.26, -39.02 -76.56, -5.95 APE12-dist-in 12.4918 APE11-dist-in 10.9019 APE10-dist-out 9.6516 APE9-dist-out 10.0285 T287D None None XRAY 2.701 0.22 0.273 A 279.0 267.0 0 26 26 0 [[133, 383]] 1.0 3uo5 Homo sapiens CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3UP7A O14965 124 387 403.0 0C9:1 Type1 Inactive DFGin 5.8193 16.3646 BLAminus -130.09, 178.76 54.57, 64.0 -79.21, 24.67 284.67, 66.9 -53.78, -49.48 in-out in 9.968 Saltbr-out 3.6332 HRD-in -77.47, -60.24 71.29, 19.44 out-in-out SNCoio in-out ActLoopNT-in 3.0058 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -38.78, -81.56 APE9-dihe-na -54.71, -160.19 APE8-dihe-in -68.17, 153.89 APE8-rot-out 200.11 APE67-dihe-in -39.24, -30.76 -95.24, -4.8 APE12-dist-in 11.5263 APE11-dist-in 9.7601 APE10-dist-out 10.8795 APE9-dist-out 10.3866 T287D None None XRAY 3.05 0.233 0.292 A 279.0 264.0 0 26 26 0 [[133, 383]] 1.0 3up7 Homo sapiens CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4DEBA O14965 125 388 403.0 NHJ:501 Type1 Inactive DFGin 5.8906 15.8517 BLAminus -118.01, 177.65 55.3, 79.43 -92.09, 27.01 282.13, 72.04 -55.45, -60.69 out-out out 10.0658 Saltbr-out 5.3839 HRD-in -81.24, -53.46 65.85, 22.78 out-in-out SNCoio in-out ActLoopNT-in 2.9159 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -66.58, 171.46 APE9-dihe-na -61.86, -44.53 APE8-dihe-in -110.19, 126.78 APE8-rot-in 317.95 APE67-dihe-in -22.11, -26.3 -79.6, -25.01 APE12-dist-in 11.9502 APE11-dist-in 10.8791 APE10-dist-out 8.6089 APE9-dist-out 11.7347 T287D None None XRAY 3.05 0.224 0.283 A 279.0 264.0 0 26 26 0 [[133, 383]] 1.0 4deb Homo sapiens CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4DEDA O14965 124 388 403.0 NHU:501 Type1 Inactive DFGin 6.072 16.0816 BLAminus -138.76, 173.27 68.31, 59.98 -87.91, 21.59 291.07, 72.61 -64.04, -43.33 in-out in 9.4883 Saltbr-out 4.3842 HRD-in -67.29, -48.42 56.74, 25.08 out-in-out SNCoio in-out ActLoopNT-in 2.8551 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -130.4, 153.53 APE9-dihe-na -61.97, -49.69 APE8-dihe-in -129.11, 146.11 APE8-rot-out 199.74 APE67-dihe-in -53.92, -43.68 -92.26, 7.7 APE12-dist-in 12.4778 APE11-dist-in 12.0621 APE10-dist-out 8.768 APE9-dist-out 10.6151 T287D None None XRAY 3.05 0.224 0.282 A 279.0 265.0 0 26 26 0 [[133, 383]] 1.0 4ded Homo sapiens CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4JBOA O14965 126 391 403.0 WPH:501 Type1 Inactive DFGin 6.9176 16.3349 BLAminus -121.96, 170.2 69.47, 92.47 -109.1, 25.94 282.47, 79.53 -73.3, -12.56 out-out out 10.5859 Saltbr-out 7.2839 HRD-in -69.78, -56.56 69.03, 0.72 out-in-out SNCoio in-out ActLoopNT-in 3.2014 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -88.96, 151.68 APE9-dihe-na 80.94, 165.59 APE8-dihe-in -59.72, 148.42 APE8-rot-out 55.11 APE67-dihe-in -45.81, -36.47 -90.07, -0.97 APE12-dist-in 7.5558 APE11-dist-in 12.071 APE10-dist-out 13.0397 APE9-dist-out 11.3997 T288D None None XRAY 2.493 0.221 0.236 A 279.0 266.0 0 26 26 0 [[133, 383]] 1.0 4jbo Homo sapiens CAMK_AURKA_HUMAN CAMK 1.6e-79 272.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3NRMA O14965 126 388 403.0 NRM:1 Type1 Inactive DFGin 6.0716 15.0961 BLAminus -130.09, -178.19 51.16, 66.82 -80.62, 35.58 277.25, 74.79 -64.12, -46.77 in-in in 9.4352 Saltbr-in 3.4443 HRD-in -74.32, -41.78 69.11, -35.94 in-in-out SNCiio in-out ActLoopNT-in 2.8743 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -92.01, -151.58 APE9-dihe-na 69.72, -164.73 APE8-dihe-in -74.0, 133.98 APE8-rot-out 208.3 APE67-dihe-in -38.38, -36.32 -102.81, -1.38 APE12-dist-out 6.7273 APE11-dist-in 10.5789 APE10-dist-out 13.3005 APE9-dist-out 11.7 T287A,T288A None None XRAY 3.05 0.223 0.258 A 283.0 263.0 0 26 26 0 [[133, 383]] 1.0 3nrm Homo sapiens CAMK_AURKA_HUMAN CAMK 4.7e-79 271.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3R21A O14965 127 389 403.0 D36:1 Type1 Inactive DFGin 6.4052 16.2492 BLAminus -119.2, 169.1 74.52, 71.15 -87.23, 26.31 291.35, 83.38 -45.72, -73.9 out-out out 10.143 Saltbr-out 3.6157 HRD-in -70.84, -47.21 71.45, -18.55 out-in-out SNCoio in-out ActLoopNT-in 3.0202 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na 106.81, 117.36 APE9-dihe-na 96.25, 137.51 APE8-dihe-in -45.73, 125.62 APE8-rot-out 178.81 APE67-dihe-in -38.05, -36.45 -80.95, -20.64 APE12-dist-none 999.0 APE11-dist-out 16.1671 APE10-dist-out 13.0563 APE9-dist-out 10.6547 T287D,T288D None None XRAY 2.9 0.26 0.305 A 271.0 254.0 9 26 17 9 [[133, 383]] 1.0 3r21 Homo sapiens CAMK_AURKA_HUMAN CAMK 1.8e-79 272.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5AADA O14965 127 388 403.0 5GX:1389 Type1 Inactive DFGin 5.2465 15.0832 BLAminus -160.19, -169.78 46.44, 81.28 -88.9, 36.75 281.82, 83.2 -69.2, -12.18 in-in in 9.6596 Saltbr-in 3.5063 HRD-in -67.01, -43.23 68.2, -42.63 in-in-out SNCiio in-out ActLoopNT-in 2.9077 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 148.29 APE8-rot-out 201.58 APE67-dihe-in -45.45, -35.82 -107.8, -3.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C290A,C393A None None XRAY 3.1 0.205 0.283 A 285.0 252.0 10 26 16 10 [[133, 383]] 1.0 5aad Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2XNEA O14965 127 388 403.0 ASH:1389 Type1 Inactive DFGin 5.6738 14.9931 BLAminus -132.18, -174.52 57.91, 85.26 -105.96, 29.74 295.12, 67.89 -63.37, -29.37 out-out out 10.2605 Saltbr-out 4.6119 HRD-in -76.3, -55.45 66.89, 8.78 out-in-out SNCoio in-out ActLoopNT-in 3.2762 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 145.72 APE8-rot-out 185.25 APE67-dihe-in -38.84, -32.2 -88.97, -18.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D274N None None XRAY 2.8 0.24 0.281 A 272.0 246.0 16 26 17 9 [[133, 383]] 1.0 2xne Homo sapiens CAMK_AURKA_HUMAN CAMK 3.8e-79 271.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5DR9A O14965 127 390 403.0 SKE:401,5E2:402 Type1,Allosteric Inactive DFGin 6.2605 16.4955 BLAminus -123.32, -163.78 43.59, 60.53 -66.54, -12.27 260.09, 81.94 -59.8, 149.1 out-out out 10.8322 Saltbr-out 5.8361 HRD-in -75.67, -56.88 79.45, -32.13 out-out-out SNCooo out-out ActLoopNT-out 3.7494 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 153.82 APE9-dihe-na -93.74, -139.43 APE8-dihe-in -48.63, 139.94 APE8-rot-in 276.28 APE67-dihe-in -58.38, -35.92 -97.04, 14.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.1214 APE9-dist-out 10.8202 T287A None None XRAY 2.47 0.227 0.262 A 273.0 257.0 7 26 19 7 [[133, 383]] 1.0 5dr9 Homo sapiens CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3M11A O14965 126 391 403.0 AKI:1 Type1.5_Front Inactive DFGin 6.9635 16.7044 BLAminus -121.88, 165.26 64.27, 67.3 -73.83, 6.74 288.37, 76.5 -59.9, -23.24 out-out out 11.1421 Saltbr-out 7.507 HRD-out -96.16, 99.79 -59.97, -43.23 out-in-out SNCoio in-out ActLoopNT-in 3.4008 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 148.15 APE8-dihe-in -53.14, 136.39 APE8-rot-in 259.54 APE67-dihe-in -40.98, -33.42 -92.04, -9.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.2546 T288D None None XRAY 2.75 0.221 0.299 A 279.0 256.0 10 26 16 10 [[133, 383]] 1.0 3m11 Homo sapiens CAMK_AURKA_HUMAN CAMK 1.6e-79 272.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4JBPA O14965 126 390 403.0 YPH:501 Type1.5_Front Inactive DFGin 5.8133 16.2215 BLAminus -117.4, 167.72 63.38, 95.52 -104.02, 27.08 282.25, 81.8 -62.06, -18.61 out-out out 10.8244 Saltbr-out 7.1644 HRD-in -70.59, -54.13 72.42, 1.53 out-in-out SNCoio in-out ActLoopNT-in 3.4752 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 161.17 APE8-dihe-in -73.05, 143.32 APE8-rot-out 208.85 APE67-dihe-in -51.16, -32.61 -84.83, -4.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5621 T288D None None XRAY 2.45 0.226 0.291 A 279.0 255.0 10 26 16 10 [[133, 383]] 1.0 4jbp Homo sapiens CAMK_AURKA_HUMAN CAMK 1.6e-79 272.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4J8MA O14965 125 390 403.0 CJ5:501 Type1 Inactive DFGin 5.3602 13.8055 BLAplus -146.29, 170.29 51.53, 44.81 -106.0, -2.95 55.0, 80.32 -73.54, 148.11 out-out out 11.7319 Saltbr-out 6.9352 HRD-out -150.5, 159.01 -82.32, 165.77 out-out-out SNCooo out-out ActLoopNT-out 10.6784 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na 70.04, -65.32 APE9-dihe-na 76.22, 9.18 APE8-dihe-out -83.72, -40.53 APE8-rot-in 297.35 APE67-dihe-in -53.15, -21.55 -46.81, -40.82 APE12-dist-out 21.5394 APE11-dist-out 19.6974 APE10-dist-out 14.9139 APE9-dist-out 13.6225 T287D None CAF247 XRAY 1.853 0.178 0.218 A 279.0 266.0 0 26 26 0 [[133, 383]] 1.0 4j8m Homo sapiens CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 8PR7D O14965 126 388 403.0 ADP:501 ATPlike Inactive DFGin 6.9163 17.6819 BLBminus -119.47, -172.43 57.55, 67.82 -98.5, 138.77 288.48, 69.88 152.2, -37.73 out-none out 11.7807 Saltbr-none 999.0 HRD-in -89.57, -45.69 63.63, 4.27 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, 178.01 APE9-dihe-na 51.17, 13.86 APE8-dihe-out -88.74, -9.17 APE8-rot-none 999.0 APE67-dihe-in -65.89, -30.04 -136.83, 2.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.9294 APE9-dist-out 11.3958 D274N,C290A,N332A,Q335A,T347A,D350A,C393A None None XRAY 2.76 0.205 0.256 D 283.0 251.0 12 26 14 12 [[133, 383]] 1.0 8pr7 Homo sapiens CAMK_AURKA_HUMAN CAMK 3e-77 265.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4C3PA O14965 125 388 403.0 ACP:1389 ATPlike Inactive DFGin 5.1209 15.3112 None -143.16, 44.14 -117.33, -72.7 63.16, 22.36 309.54, 103.5 -71.05, -27.42 out-out out 10.7129 Saltbr-out 4.9547 HRD-out -79.39, 150.41 -121.39, -68.05 out-in-out SNCoio in-out ActLoopNT-in 2.8189 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -49.34, 122.38 APE9-dihe-na 116.03, -35.9 APE8-dihe-out -100.65, -0.54 APE8-rot-out 177.69 APE67-dihe-in -57.5, -32.82 -45.19, -41.29 APE12-dist-out 20.9276 APE11-dist-out 21.1759 APE10-dist-out 26.1561 APE9-dist-out 28.5914 None None None XRAY 2.69 0.205 0.289 A 282.0 264.0 0 26 26 0 [[133, 383]] 1.0 4c3p Homo sapiens CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2C6DA O14965 126 390 403.0 ANP:61391 ATPlike Inactive DFGin 6.2574 16.4224 None -70.12, 150.14 -40.51, 101.21 -55.1, 131.85 61.77, 102.87 98.63, -164.78 out-out out 13.1601 Saltbr-out 13.9978 HRD-out -91.98, 166.93 -128.47, 87.17 out-out-out SNCooo out-out ActLoopNT-out 17.9333 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 134.8 APE8-dihe-in -71.63, 167.98 APE8-rot-out 60.54 APE67-dihe-in -57.74, -18.95 -51.64, -36.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.0437 None None None XRAY 2.2 0.23 0.28 A 275.0 255.0 10 26 16 10 [[133, 383]] 1.0 2c6d Homo sapiens CAMK_AURKA_HUMAN CAMK 1.5e-79 272.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5ODTA O14965 126 392 403.0 ADP:501 ATPlike Inactive DFGin 6.7171 16.9598 None -121.13, 4.47 -111.78, 32.81 -79.52, 164.76 286.94, 96.78 78.48, -128.28 out-out out 11.7478 Saltbr-out 10.767 HRD-out -137.93, 83.59 -73.55, -34.72 out-out-out SNCooo out-out ActLoopNT-out 17.7885 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, -15.28 APE9-dihe-na -98.55, 177.35 APE8-dihe-out 65.78, -46.63 APE8-rot-none 999.0 APE67-dihe-in -47.55, -29.4 -45.89, -32.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 24.8668 APE9-dist-out 13.4366 D274N,C290A,C393A None None XRAY 2.021 0.179 0.211 A 283.0 258.0 9 26 17 9 [[133, 383]] 1.0 5odt Homo sapiens CAMK_AURKA_HUMAN CAMK 5.4e-78 267.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5OBJA O14965 127 390 403.0 ATP:404,9QK:405 ATPlike,Allosteric Inactive DFGin 6.016 15.9671 None -127.31, -156.34 57.9, -96.92 69.6, 25.6 277.68, 99.91 -74.82, -34.09 out-out out 10.8688 Saltbr-out 3.9746 HRD-in -84.35, -43.15 67.43, 1.86 out-in-out SNCoio in-out ActLoopNT-in 2.747 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -85.06 APE9-dihe-na -106.73, -153.17 APE8-dihe-in -86.88, 144.13 APE8-rot-in 279.73 APE67-dihe-in -52.07, -35.29 -66.02, -11.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.3791 APE9-dist-out 10.1992 None None None XRAY 2.901 0.215 0.245 A 272.0 260.0 4 26 22 4 [[133, 383]] 1.0 5obj Homo sapiens CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 9GUCA O14965 124 391 403.0 ADP:501,AMP:503 ATPlike,Allosteric Inactive DFGin 7.1772 17.543 None -98.47, -53.8 -99.76, 123.69 -123.57, 999.0 272.41, 116.36 999.0, 999.0 out-none out 10.8811 Saltbr-none 999.0 HRD-in -77.17, -58.19 77.29, 1.39 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na -78.2, -27.21 APE9-dihe-na 141.47, -167.5 APE8-dihe-in -95.93, 123.55 APE8-rot-in 299.51 APE67-dihe-in -57.72, -20.14 -51.84, -47.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.7077 C290A,C393A None None XRAY 2.1 0.193 0.232 A 285.0 256.0 12 26 14 12 [[133, 383]] 1.0 9guc Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 8JF4A O14965 127 389 403.0 C0N:401 Type1 Inactive DFGin 7.2529 17.8729 None -135.45, -161.79 63.9, -97.55 64.54, 6.09 245.37, 117.13 -63.89, -23.61 out-none out 12.6402 Saltbr-none 999.0 HRD-out -120.1, 149.54 -137.31, -168.1 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -130.74 APE9-dihe-na -95.79, -164.69 APE8-dihe-in -61.45, 121.57 APE8-rot-in 284.06 APE67-dihe-in -41.63, -35.05 -74.97, -8.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.8848 APE9-dist-out 12.0317 None None None XRAY 2.893 0.241 0.3 A 263.0 252.0 11 26 15 11 [[133, 383]] 1.0 8jf4 Homo sapiens CAMK_AURKA_HUMAN CAMK 5.7e-80 274.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 8JMXA O14965 127 389 403.0 E47:401 Type1 Inactive DFGin 8.1479 17.9382 None -66.97, -135.61 -86.55, 178.72 -114.61, 4.13 278.35, 26.61 128.02, 999.0 out-none out 12.4603 Saltbr-none 999.0 HRD-out -175.92, -143.93 -146.96, -121.49 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, -148.55 APE9-dihe-na -86.45, -174.61 APE8-dihe-out -81.39, -14.34 APE8-rot-out 176.74 APE67-dihe-out -64.27, -11.38 79.63, -40.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.3418 None None None XRAY 2.95 0.231 0.306 A 263.0 250.0 13 26 13 13 [[133, 383]] 1.0 8jmx Homo sapiens CAMK_AURKA_HUMAN CAMK 5.7e-80 274.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 7AYIA O14965 125 392 403.0 S9K:501 Type1 Inactive DFGin 5.4193 15.6223 None -144.41, -177.78 68.28, 27.25 -31.37, 999.0 286.89, 77.45 999.0, 999.0 out-out out 11.6263 Saltbr-out 5.2735 HRD-out -134.3, 170.16 -127.02, -53.3 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -25.37 APE8-rot-out 50.94 APE67-dihe-in -37.9, -35.61 -58.22, -27.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.86 0.254 0.297 A 285.0 252.0 16 26 10 16 [[133, 383]] 1.0 7ayi Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2J4ZB O14965 126 395 403.0 626:1395 Type1 Inactive DFGin 4.2178 13.6848 None -135.88, 74.16 -114.29, 33.41 -89.42, 114.89 302.17, 82.01 -8.53, 159.28 out-out out 11.4154 Saltbr-out 7.1624 HRD-out 58.44, 64.77 -95.37, 159.29 out-out-out SNCooo out-out ActLoopNT-out 18.7148 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -94.91, -9.28 APE9-dihe-na 130.48, -157.55 APE8-dihe-in -66.91, 118.34 APE8-rot-in 305.65 APE67-dihe-in -61.18, -13.87 -47.83, -58.47 APE12-dist-out 16.9419 APE11-dist-out 16.0005 APE10-dist-out 16.5324 APE9-dist-out 8.9625 None None None XRAY 2.0 0.214 0.249 B 306.0 270.0 0 26 26 0 [[133, 383]] 1.0 2j4z Homo sapiens CAMK_AURKA_HUMAN CAMK 9.9e-80 273.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4O0WA O14965 125 391 403.0 ADN:501 Type1 Inactive DFGin 6.2719 16.5981 None -99.25, -54.63 -80.04, -74.28 72.86, -1.54 279.35, 93.09 -53.76, -20.49 out-out out 11.3192 Saltbr-out 4.9936 HRD-in -77.36, -61.61 76.79, -35.67 out-in-out SNCoio in-out ActLoopNT-in 2.7811 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -96.78, 99.9 APE9-dihe-na 173.74, 169.14 APE8-dihe-in -81.74, 143.07 APE8-rot-out 200.15 APE67-dihe-in -47.45, -41.6 -91.34, -9.3 APE12-dist-none 999.0 APE11-dist-in 12.2482 APE10-dist-out 14.98 APE9-dist-out 11.7548 H254Y None None XRAY 2.6 0.246 0.277 A 282.0 259.0 8 26 18 8 [[133, 383]] 1.0 4o0w Homo sapiens CAMK_AURKA_HUMAN CAMK 1.5e-78 269.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3H0ZA O14965 128 388 403.0 45B:1 Type1 Inactive DFGin 7.3472 16.083 None -89.96, 161.55 64.52, -172.92 -163.13, -57.24 280.93, 123.29 171.24, 120.64 out-out out 10.3185 Saltbr-out 7.3796 HRD-out -71.52, 144.0 -92.02, -55.66 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 126.34 APE8-rot-out 164.31 APE67-dihe-in -55.12, -32.9 -104.49, -8.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K124A,T287A,T288A None None XRAY 2.92 0.221 0.286 A 268.0 248.0 13 26 13 13 [[133, 383]] 1.0 3h0z Homo sapiens CAMK_AURKA_HUMAN CAMK 3.9e-79 271.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4DHFA O14965 128 389 403.0 0K6:401 Type1 Inactive DFGin 6.0606 15.9561 None -124.92, -165.4 70.7, -102.39 69.61, 140.83 290.26, 89.34 63.95, 95.41 in-in in 8.9889 Saltbr-in 2.893 HRD-in -73.28, -47.83 72.66, -2.67 in-in-out SNCiio in-out ActLoopNT-in 3.5586 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -6.14 APE9-dihe-na -59.01, 54.1 APE8-dihe-out 19.82, 17.91 APE8-rot-out 105.73 APE67-dihe-out -28.21, -43.1 61.5, -49.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.7292 APE9-dist-out 7.9962 T287D,T288D None None XRAY 2.8 0.21 0.299 A 271.0 258.0 4 26 22 4 [[133, 383]] 1.0 4dhf Homo sapiens CAMK_AURKA_HUMAN CAMK 1.8e-79 272.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4DHFB O14965 128 389 403.0 0K6:401 Type1 Inactive DFGin 6.2133 16.1482 None -129.3, -166.63 71.78, -102.87 78.31, 163.45 277.6, 93.12 43.8, 85.35 in-in in 9.3755 Saltbr-in 3.1006 HRD-in -78.27, -44.01 67.72, -6.17 in-in-out SNCiio in-out ActLoopNT-in 2.9195 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -62.03 APE9-dihe-na -175.18, -54.66 APE8-dihe-out 61.81, -74.57 APE8-rot-out 81.7 APE67-dihe-out -53.34, -26.37 96.06, -28.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.9693 APE9-dist-out 10.0958 T287D,T288D None None XRAY 2.8 0.21 0.299 B 271.0 258.0 4 26 22 4 [[133, 383]] 1.0 4dhf Homo sapiens CAMK_AURKA_HUMAN CAMK 1.8e-79 272.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4PRJA O14965 125 388 403.0 2VU:401 Type1 Inactive DFGin 5.9517 15.2568 None -87.9, -78.85 -67.3, 132.08 -130.02, 25.75 273.54, 81.31 -60.0, -22.81 in-in in 9.9032 Saltbr-in 3.107 HRD-in -70.35, -53.13 72.43, -26.65 in-in-out SNCiio in-out ActLoopNT-in 3.0892 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnoo APE10-dihe-na 999.0, 60.06 APE9-dihe-na -85.89, -100.42 APE8-dihe-in -76.32, 127.81 APE8-rot-out 186.15 APE67-dihe-out -49.54, 145.49 -72.25, -20.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.5199 APE9-dist-out 11.3043 K124A,Q154N,A203S,R251K,T287A,T288A,E336D None None XRAY 2.8 0.233 0.275 A 269.0 251.0 13 26 16 10 [[133, 383]] 1.0 4prj Homo sapiens CAMK_AURKA_HUMAN CAMK 6.9e-79 270.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5AAEA O14965 126 388 403.0 7HD:1389 Type1 Inactive DFGin 5.9398 15.1503 None -95.89, -104.86 -82.25, 148.83 -122.78, 23.14 291.0, 74.49 -53.63, -36.45 out-none out 10.8697 Saltbr-none 999.0 HRD-in -83.0, -21.45 60.1, -65.55 none-in-out SNCnio in-out ActLoopNT-in 3.0061 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -177.84 APE8-dihe-in -88.91, 121.07 APE8-rot-out 73.44 APE67-dihe-in -49.15, -25.21 -87.19, -36.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0803 C290A,C393A None None XRAY 3.11 0.241 0.291 A 285.0 252.0 11 26 15 11 [[133, 383]] 1.0 5aae Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4O0UA O14965 126 391 403.0 ADN:501 Type1 Inactive DFGin 6.2642 11.4304 None -100.67, -17.12 -134.58, 129.02 -80.64, -37.58 28.72, 51.86 64.49, -126.4 out-out out 12.2241 Saltbr-out 10.2319 HRD-out -138.46, 154.69 -78.12, -46.1 out-in-out SNCoio in-out ActLoopNT-in 3.5193 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -78.11, -47.49 APE9-dihe-na -96.12, 155.1 APE8-dihe-in -73.36, 140.7 APE8-rot-out 180.88 APE67-dihe-in -47.54, -36.76 -84.86, -11.52 APE12-dist-out 18.1413 APE11-dist-out 15.8917 APE10-dist-out 13.345 APE9-dist-out 11.2984 H254R None None XRAY 2.6 0.236 0.273 A 282.0 259.0 7 26 19 7 [[133, 383]] 1.0 4o0u Homo sapiens CAMK_AURKA_HUMAN CAMK 3.5e-78 268.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4UZDA O14965 127 388 403.0 QMN:1389 Type1.5_Front Inactive DFGin 4.7703 14.7373 None -129.81, 37.03 -50.55, -31.01 -53.57, 125.59 325.32, 89.96 118.13, 999.0 out-out out 11.6146 Saltbr-out 8.8418 HRD-out 53.57, 64.67 -94.14, 134.34 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -65.57, -29.93 APE9-dihe-na 142.25, -148.89 APE8-dihe-in -77.46, 105.91 APE8-rot-in 292.33 APE67-dihe-in -60.25, -12.9 -39.34, -60.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.5975 None None None XRAY 3.2 0.215 0.262 A 287.0 254.0 8 26 18 8 [[133, 383]] 1.0 4uzd Homo sapiens CAMK_AURKA_HUMAN CAMK 7.9e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4UZDB O14965 125 389 403.0 QMN:1390 Type1.5_Front Inactive DFGin 4.5757 14.7196 None -129.5, 39.33 -48.31, -42.14 -43.39, 138.93 326.34, 95.13 97.81, -168.36 out-out out 11.585 Saltbr-out 9.3972 HRD-out 50.88, 59.12 -92.12, 140.19 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -64.7, -29.88 APE9-dihe-na 143.96, -147.24 APE8-dihe-in -77.35, 106.49 APE8-rot-in 291.41 APE67-dihe-in -62.64, -12.41 -49.18, -49.73 APE12-dist-out 16.5866 APE11-dist-out 15.4049 APE10-dist-out 16.5271 APE9-dist-out 9.5026 None None None XRAY 3.2 0.215 0.262 B 287.0 258.0 7 26 19 7 [[133, 383]] 1.0 4uzd Homo sapiens CAMK_AURKA_HUMAN CAMK 7.9e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4UYNA O14965 125 391 403.0 Y3M:1392 Type1.5_Front Inactive DFGin 4.6948 14.0105 None -129.71, 33.27 -11.88, -124.06 104.64, 86.61 36.8, 56.54 29.97, 999.0 out-out out 11.4313 Saltbr-out 9.4418 HRD-out 56.55, 66.12 -91.27, 149.56 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -53.31, -27.51 999.0, -36.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.201 0.234 A 287.0 249.0 18 26 10 16 [[133, 383]] 1.0 4uyn Homo sapiens CAMK_AURKA_HUMAN CAMK 1.8e-79 272.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4C3RA O14965 127 388 403.0 ACP:1389 ATPlike Inactive DFGinter 6.0871 8.639 None -114.31, -7.36 -87.64, 130.6 -72.8, -47.16 285.43, 29.08 69.28, 138.63 out-out out 11.9632 Saltbr-out 7.7849 HRD-out -148.79, 112.09 -68.12, -80.01 out-out-out SNCooo out-out ActLoopNT-out 8.0165 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 137.49 APE8-dihe-in -74.84, 138.8 APE8-rot-out 199.32 APE67-dihe-in -50.64, -36.72 -89.13, -8.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.2314 None None None XRAY 2.79 0.229 0.306 A 282.0 252.0 10 26 16 10 [[133, 383]] 1.0 4c3r Homo sapiens CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 6C83B O14965 127 388 403.0 ACP:501 ATPlike Inactive DFGinter 7.3169 8.5877 None -129.69, 90.85 -100.04, 101.37 -135.34, 999.0 303.1, 99.49 999.0, 999.0 out-out out 12.1149 Saltbr-out 10.0494 HRD-out -96.09, 116.19 -110.78, 111.97 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -90.23 APE8-dihe-out -77.58, -0.58 APE8-rot-out 85.03 APE67-dihe-in -69.49, -5.14 -61.84, -44.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.4721 None None None XRAY 2.55 0.268 0.322 B 285.0 247.0 15 26 11 15 [[133, 383]] 1.0 6c83 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5L8JA O14965 126 391 403.0 ADP:60501 ATPlike Inactive DFGinter 6.0388 8.8115 None -121.42, -0.81 -92.81, -3.45 60.99, 19.44 297.14, 26.84 -77.84, 60.22 out-out out 13.2014 Saltbr-out 9.5877 HRD-out -100.39, 154.9 -77.66, -154.82 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 16.48 APE8-rot-out 62.75 APE67-dihe-in -57.65, -20.32 -54.21, -40.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C290A,C393A TPO288 TPO288 XRAY 1.68 0.201 0.231 A 285.0 253.0 13 26 13 13 [[133, 383]] 1.0 5l8j Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5L8KA O14965 126 392 403.0 ADP:60501 ATPlike Inactive DFGinter 5.9336 8.6956 None -123.53, 3.87 -94.88, 4.13 51.12, 25.43 307.6, 8.65 -83.23, 69.32 out-out out 12.9065 Saltbr-out 9.1369 HRD-out -94.24, 154.96 -82.75, -161.39 out-out-out SNCooo out-out ActLoopNT-out 5.2619 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -60.54, 152.13 APE9-dihe-na 121.57, -104.82 APE8-dihe-in -138.45, 120.03 APE8-rot-in 300.38 APE67-dihe-in -56.47, -22.96 -75.46, -21.38 APE12-dist-out 14.1901 APE11-dist-out 17.8848 APE10-dist-out 19.7221 APE9-dist-out 13.7291 C290A,C393A TPO288 TPO288 XRAY 1.79 0.192 0.235 A 285.0 267.0 0 26 26 0 [[133, 383]] 1.0 5l8k Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5L8LA O14965 126 389 403.0 ADP:60501 ATPlike Inactive DFGinter 5.6468 8.8822 None -117.8, 6.57 -92.89, -1.12 53.22, 20.44 289.58, 36.26 -84.0, 68.46 out-out out 12.5405 Saltbr-out 9.0265 HRD-out -99.09, 148.91 -94.35, -164.8 out-out-out SNCooo out-out ActLoopNT-out 5.3927 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -75.26, -165.41 APE9-dihe-na -67.89, -63.26 APE8-dihe-out -124.39, -179.64 APE8-rot-out 64.28 APE67-dihe-in -57.8, -26.84 -83.02, -0.31 APE12-dist-in 11.1091 APE11-dist-out 16.5204 APE10-dist-out 14.4907 APE9-dist-out 14.6386 C290A,C393A TPO288 TPO288 XRAY 1.67 0.193 0.223 A 285.0 264.0 0 26 26 0 [[133, 383]] 1.0 5l8l Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 8PR7A O14965 124 389 403.0 ADP:501 ATPlike Inactive DFGinter 5.0698 10.2727 None -105.95, 148.75 -124.79, 28.7 -129.06, 999.0 303.51, 120.23 999.0, 999.0 out-out out 12.4819 Saltbr-out 11.7057 HRD-out 52.78, 71.6 -97.43, 142.22 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 47.95, -115.05 APE9-dihe-na -125.01, 9.37 APE8-dihe-out -40.29, -50.01 APE8-rot-out 85.86 APE67-dihe-in -55.11, -34.07 -62.49, -38.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.8319 D274N,C290A,N332A,Q335A,T347A,D350A,C393A None None XRAY 2.76 0.205 0.256 A 283.0 253.0 13 26 13 13 [[133, 383]] 1.0 8pr7 Homo sapiens CAMK_AURKA_HUMAN CAMK 3e-77 265.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 6XKAA O14965 127 388 403.0 No_ligand No_ligand Inactive DFGinter 8.9294 7.5102 None -127.13, 56.47 -140.31, 176.96 -101.27, 7.78 308.94, 105.52 -69.78, 61.67 out-out out 12.6318 Saltbr-out 9.0191 HRD-out -107.58, 148.94 -95.64, -139.96 out-out-out SNCooo out-out ActLoopNT-out 5.4147 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -48.95 APE8-dihe-out -61.69, -24.7 APE8-rot-in 274.82 APE67-dihe-in -56.0, -24.76 -53.72, -21.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 35.0529 None None None XRAY 2.65 0.226 0.279 A 292.0 252.0 10 26 16 10 [[133, 383]] 1.0 6xka Homo sapiens CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2WTVA O14965 125 389 403.0 ZZL:1390 Type1 Inactive DFGinter 5.7006 9.4543 None -75.22, 156.08 -105.21, 156.98 57.55, 45.32 319.02, 110.91 -59.58, -21.68 out-out out 12.2244 Saltbr-out 9.7382 HRD-out 56.62, 39.51 -65.34, 136.35 out-out-out SNCooo out-out ActLoopNT-out 17.312 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -58.52, -47.8 APE9-dihe-na -54.18, -45.12 APE8-dihe-out -70.51, -43.3 APE8-rot-in 297.14 APE67-dihe-in -48.3, -25.92 -57.93, -45.43 APE12-dist-in 8.2869 APE11-dist-in 12.3199 APE10-dist-out 15.0391 APE9-dist-out 12.5887 L215R,T217E,R220K TPO287,TPO288 TPO287,TPO288,CME290 XRAY 2.4 0.167 0.211 A 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 2wtv Homo sapiens CAMK_AURKA_HUMAN CAMK 2.7e-81 278.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2WTVB O14965 126 389 403.0 ZZL:1390 Type1 Inactive DFGinter 5.619 9.4225 None -74.68, 158.58 -101.8, 146.26 63.97, 49.3 317.28, 114.07 -55.55, -26.4 out-out out 12.4193 Saltbr-out 10.2967 HRD-out -138.44, 123.91 -119.97, 134.75 out-out-out SNCooo out-out ActLoopNT-out 19.5109 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na 85.02, 1.5 APE9-dihe-na 116.84, -135.44 APE8-dihe-in -82.25, 112.82 APE8-rot-in 306.92 APE67-dihe-in -64.29, -12.84 -49.83, -55.07 APE12-dist-out 14.754 APE11-dist-out 14.7502 APE10-dist-out 12.235 APE9-dist-out 12.2869 L215R,T217E,R220K TPO287,TPO288 TPO287,TPO288,CME290 XRAY 2.4 0.167 0.211 B 285.0 264.0 0 26 26 0 [[133, 383]] 1.0 2wtv Homo sapiens CAMK_AURKA_HUMAN CAMK 2.7e-81 278.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2WTVC O14965 126 389 403.0 ZZL:1392 Type1 Inactive DFGinter 5.6558 9.3615 None -73.47, 155.34 -96.85, 146.28 67.08, 43.87 316.19, 116.1 -46.77, -31.93 out-out out 12.3893 Saltbr-out 10.3055 HRD-out -138.88, 125.11 -124.14, 137.81 out-out-out SNCooo out-out ActLoopNT-out 19.519 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na 85.46, 1.21 APE9-dihe-na 119.13, -135.87 APE8-dihe-in -82.97, 108.09 APE8-rot-in 299.33 APE67-dihe-in -62.27, -12.5 -42.96, -58.15 APE12-dist-out 14.7656 APE11-dist-out 14.7278 APE10-dist-out 12.2667 APE9-dist-out 12.403 L215R,T217E,R220K TPO287,TPO288 TPO287,TPO288,CME290 XRAY 2.4 0.167 0.211 C 285.0 264.0 0 26 26 0 [[133, 383]] 1.0 2wtv Homo sapiens CAMK_AURKA_HUMAN CAMK 2.7e-81 278.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2WTVD O14965 125 389 403.0 ZZL:1390 Type1 Inactive DFGinter 5.688 9.4465 None -74.49, 159.41 -108.43, 161.13 55.07, 43.29 317.21, 115.65 -58.54, -27.22 out-out out 12.1938 Saltbr-out 9.7964 HRD-out 49.31, 42.91 -68.48, 131.43 out-out-out SNCooo out-out ActLoopNT-out 17.0587 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -57.61, -41.18 APE9-dihe-na -56.01, -51.32 APE8-dihe-out -76.54, -36.16 APE8-rot-out 70.56 APE67-dihe-in -47.19, -33.07 -56.26, -46.95 APE12-dist-in 8.3139 APE11-dist-in 12.4802 APE10-dist-out 15.096 APE9-dist-out 12.4934 L215R,T217E,R220K TPO287,TPO288 TPO287,TPO288,CME290 XRAY 2.4 0.167 0.211 D 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 2wtv Homo sapiens CAMK_AURKA_HUMAN CAMK 2.7e-81 278.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5EW9A O14965 127 390 403.0 5VC:1000 Type1 Inactive DFGinter 7.1431 9.1464 None -125.76, 68.03 -116.07, 111.14 -114.04, 30.21 299.83, 98.64 76.42, 31.17 out-out out 12.2084 Saltbr-out 14.928 HRD-out 51.87, 61.64 -81.46, 128.2 out-out-out SNCooo out-out ActLoopNT-out 13.1788 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -81.31, 136.15 APE9-dihe-na 106.85, -151.62 APE8-dihe-in -130.38, 126.41 APE8-rot-in 294.67 APE67-dihe-in -61.4, -16.67 -41.18, -56.68 APE12-dist-in 12.1083 APE11-dist-in 12.3747 APE10-dist-out 8.7535 APE9-dist-out 7.2605 None TPO287,TPO288 TPO287,TPO288 XRAY 2.181 0.191 0.237 A 271.0 259.0 5 26 21 5 [[133, 383]] 1.0 5ew9 Homo sapiens CAMK_AURKA_HUMAN CAMK 6.3e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 6C2RA O14965 128 389 403.0 EG7:404 Type1 Inactive DFGinter 9.1622 6.9873 None -129.68, 71.59 -143.19, 175.42 -111.66, 41.6 306.56, 98.21 -112.1, 49.9 out-none out 12.5467 Saltbr-none 999.0 HRD-out -119.24, 148.11 -82.73, -152.25 none-out-out SNCnoo out-out ActLoopNT-out 5.5402 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -49.7 APE8-rot-out 174.63 APE67-dihe-in -50.05, -30.9 -49.27, -45.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.96 0.187 0.228 A 272.0 250.0 12 26 14 12 [[133, 383]] 1.0 6c2r Homo sapiens CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 6C2TA O14965 128 388 403.0 EGJ:401 Type1 Inactive DFGinter 5.758 8.6067 None -125.5, 12.46 -90.2, -9.56 59.46, 21.11 281.41, 42.78 -76.77, 51.45 out-out out 12.1381 Saltbr-out 8.2211 HRD-out -119.45, 155.85 -86.58, -149.59 out-out-out SNCooo out-out ActLoopNT-out 5.4123 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -68.15, 136.69 APE9-dihe-na 71.69, 6.8 APE8-dihe-out -94.33, -26.09 APE8-rot-out 197.45 APE67-dihe-in -52.44, -25.84 -48.85, -45.94 APE12-dist-out 23.1217 APE11-dist-out 26.7222 APE10-dist-out 30.388 APE9-dist-out 34.8387 None None None XRAY 1.73 0.185 0.22 A 272.0 253.0 8 26 18 8 [[133, 383]] 1.0 6c2t Homo sapiens CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3W16A O14965 126 388 403.0 P9J:501 Type1 Inactive DFGinter 8.4189 7.0708 None -121.69, 15.12 -95.95, 166.06 -111.07, 78.29 312.23, 83.01 -146.87, 73.18 out-out out 12.3431 Saltbr-out 10.3281 HRD-out -113.79, 141.39 -72.7, -138.65 out-out-out SNCooo out-out ActLoopNT-out 5.3951 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 65.19 APE8-dihe-in -37.14, 90.48 APE8-rot-out 235.25 APE67-dihe-out -39.45, -35.35 47.17, -54.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.4937 None None None XRAY 2.8 0.235 0.322 A 278.0 249.0 14 26 15 11 [[133, 383]] 1.0 3w16 Homo sapiens CAMK_AURKA_HUMAN CAMK 7e-80 274.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2J50A O14965 128 389 403.0 627:1390 Type1 Inactive DFGinter 9.2461 7.0202 None -113.57, -10.87 -64.28, 174.0 -114.87, 30.19 305.8, 146.38 -88.31, 66.84 out-out out 12.5095 Saltbr-out 9.2938 HRD-out -123.95, 152.65 -81.99, -145.81 out-out-out SNCooo out-out ActLoopNT-out 5.4444 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -105.31, 129.43 APE9-dihe-na 72.62, 27.27 APE8-dihe-out -102.11, -34.98 APE8-rot-in 309.79 APE67-dihe-in -58.95, -17.94 -50.8, -43.26 APE12-dist-out 19.5659 APE11-dist-out 16.6559 APE10-dist-out 20.8024 APE9-dist-out 14.6959 None None None XRAY 3.0 0.221 0.268 A 280.0 250.0 12 26 18 8 [[133, 383]] 1.0 2j50 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2J50B O14965 128 389 403.0 627:1390 Type1 Inactive DFGinter 9.2456 7.02 None -113.53, -10.86 -64.28, 174.02 -114.89, 30.13 305.81, 146.41 -88.25, 66.85 out-out out 12.5096 Saltbr-out 9.2936 HRD-out -123.96, 152.62 -82.01, -145.78 out-out-out SNCooo out-out ActLoopNT-out 5.4447 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -105.31, 129.37 APE9-dihe-na 72.63, 27.29 APE8-dihe-out -102.14, -34.97 APE8-rot-in 309.77 APE67-dihe-in -58.91, -17.97 -50.79, -43.31 APE12-dist-out 19.5656 APE11-dist-out 16.6557 APE10-dist-out 20.8022 APE9-dist-out 14.6957 None None None XRAY 3.0 0.221 0.268 B 280.0 250.0 12 26 18 8 [[133, 383]] 1.0 2j50 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4ZTRA O14965 127 388 403.0 4RJ:501 Type1 Inactive DFGinter 8.9966 8.6737 None -145.71, 65.97 -113.49, 176.73 -135.74, 26.63 211.29, 77.47 -104.42, 142.78 out-out out 13.0732 Saltbr-out 9.5025 HRD-out 62.28, 87.69 -105.24, 141.97 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -99.17 APE8-dihe-in -82.2, 138.42 APE8-rot-out 194.18 APE67-dihe-in -47.8, -30.35 -87.76, -14.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.4904 None None None XRAY 2.85 0.215 0.268 A 285.0 249.0 13 26 13 13 [[133, 383]] 1.0 4ztr Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 6Z4YA O14965 124 389 403.0 Q7Q:508 Type1 Inactive DFGinter 5.7933 8.4854 None -99.87, -29.52 -56.3, 117.27 -64.91, 155.66 280.74, 8.23 -48.06, 135.67 out-out out 12.2611 Saltbr-out 8.7243 HRD-out -130.04, 168.56 -116.49, -65.11 out-out-out SNCooo out-out ActLoopNT-out 8.298 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 118.23 APE9-dihe-na -146.9, 152.55 APE8-dihe-in -65.96, 130.4 APE8-rot-in 311.48 APE67-dihe-in -49.06, -39.99 -82.96, -11.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.1746 APE9-dist-out 11.1005 None None None XRAY 2.25 0.209 0.257 A 285.0 259.0 7 26 19 7 [[133, 383]] 1.0 6z4y Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 6CPGA O14965 127 387 403.0 35R:501 Type1 Inactive DFGinter 6.711 9.4851 None -140.02, 96.03 -108.44, 103.16 -141.15, -67.9 302.74, 112.44 175.19, -125.6 out-out out 12.4294 Saltbr-out 10.9407 HRD-out 55.39, 71.59 -104.21, 123.45 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, -80.02 APE9-dihe-na 97.77, -146.55 APE8-dihe-out -62.97, -12.48 APE8-rot-none 999.0 APE67-dihe-in -58.41, -29.26 -54.85, -41.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.0413 APE9-dist-out 13.6566 None None None XRAY 2.8 0.285 0.335 A 285.0 249.0 12 26 14 12 [[133, 383]] 1.0 6cpg Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 6CPGD O14965 127 388 403.0 35R:501 Type1 Inactive DFGinter 6.4037 9.7723 None -125.89, 77.36 -98.94, 84.58 -127.68, 52.17 302.92, 103.94 97.64, -149.27 out-out out 11.6201 Saltbr-out 12.7753 HRD-out 61.84, 98.64 -116.43, 122.15 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nooo APE10-dihe-na -115.97, 178.85 APE9-dihe-na -115.52, -132.49 APE8-dihe-out -76.59, 1.28 APE8-rot-out 68.27 APE67-dihe-in -65.85, -12.72 -75.15, -27.74 APE12-dist-none 999.0 APE11-dist-out 19.3876 APE10-dist-out 16.4598 APE9-dist-out 14.8298 None None None XRAY 2.8 0.285 0.335 D 285.0 252.0 10 26 16 10 [[133, 383]] 1.0 6cpg Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 8SSOA O14965 127 389 403.0 627:503 Type1 Inactive DFGinter 5.3986 10.215 None -108.08, -33.36 50.1, -154.98 50.19, 34.56 301.31, 89.86 -57.19, -31.19 out-out out 12.3336 Saltbr-out 8.6183 HRD-out 58.03, 59.93 -81.1, 151.47 out-out-out SNCooo out-out ActLoopNT-out 16.6026 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na -77.17, 142.4 APE9-dihe-na -91.52, -9.13 APE8-dihe-out -58.73, -51.63 APE8-rot-in 325.37 APE67-dihe-in -60.47, -22.49 -51.35, -46.12 APE12-dist-none 999.0 APE11-dist-out 14.2442 APE10-dist-out 9.6966 APE9-dist-out 11.7439 None None None XRAY 1.97 0.194 0.234 A 285.0 256.0 7 26 19 7 [[133, 383]] 1.0 8sso Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 8SSOD O14965 127 389 403.0 627:501 Type1 Inactive DFGinter 5.2809 10.1223 None -105.7, -31.6 53.01, -156.16 52.08, 37.65 306.05, 89.37 -57.92, -31.1 out-out out 12.2914 Saltbr-out 8.4761 HRD-out 56.18, 68.26 -87.55, 151.34 out-out-none SNCoon out-none ActLoopNT-out 16.7335 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -51.48 APE8-rot-in 286.23 APE67-dihe-in -64.32, -21.7 -60.98, -32.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.97 0.194 0.234 D 285.0 252.0 11 26 15 11 [[133, 383]] 1.0 8sso Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 1MUOA O14965 128 388 403.0 ADN:1 Type1 Inactive DFGinter 5.924 9.0061 None -137.2, 91.65 -102.67, 104.14 -141.95, -158.0 317.38, 80.93 -72.97, -80.68 out-out out 11.3153 Saltbr-out 7.8585 HRD-out -71.01, -147.46 164.07, -11.44 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na -39.4, -7.29 APE9-dihe-na -9.41, -37.67 APE8-dihe-out -44.74, -65.33 APE8-rot-in 311.2 APE67-dihe-in -15.91, -41.07 -76.59, -51.98 APE12-dist-none 999.0 APE11-dist-out 18.1963 APE10-dist-out 19.8486 APE9-dist-out 11.811 None None None XRAY 2.9 0.26 0.29 A 297.0 251.0 10 26 16 10 [[133, 383]] 1.0 1muo Homo sapiens CAMK_AURKA_HUMAN CAMK 8.9e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2J4ZA O14965 126 389 403.0 626:1389 Type1 Inactive DFGinter 6.6272 9.7164 None -134.66, 62.98 -108.04, 40.82 -66.1, -23.24 173.81, 60.57 87.3, -158.48 out-out out 12.4364 Saltbr-out 8.0569 HRD-out 53.27, 78.66 -109.39, 156.45 out-out-out SNCooo out-out ActLoopNT-out 18.6354 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -90.61, -7.12 APE9-dihe-na 129.6, -174.7 APE8-dihe-in -67.83, 122.81 APE8-rot-in 307.59 APE67-dihe-in -55.64, -29.26 -49.16, -49.7 APE12-dist-out 15.5335 APE11-dist-in 13.8401 APE10-dist-out 16.3737 APE9-dist-out 7.6149 None None None XRAY 2.0 0.214 0.249 A 306.0 264.0 0 26 26 0 [[133, 383]] 1.0 2j4z Homo sapiens CAMK_AURKA_HUMAN CAMK 9.9e-80 273.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3UNZA O14965 127 389 403.0 0BZ:2 Type1 Inactive DFGinter 5.99 8.9219 None -84.5, -63.75 54.99, -138.14 56.38, -121.0 215.05, 157.51 -49.6, 129.64 out-out out 11.6353 Saltbr-out 8.5069 HRD-out 65.37, 47.67 -71.53, 145.54 out-out-out SNCooo out-out ActLoopNT-out 17.1615 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 99.65, -2.93 APE9-dihe-na -89.71, 20.26 APE8-dihe-out -80.64, -73.77 APE8-rot-out 51.18 APE67-dihe-in -55.59, -35.44 -82.63, -1.22 APE12-dist-out 14.5531 APE11-dist-in 10.8394 APE10-dist-out 15.946 APE9-dist-out 14.0456 T287D None None XRAY 2.8 0.231 0.278 A 279.0 263.0 0 26 26 0 [[133, 383]] 1.0 3unz Homo sapiens CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3UNZB O14965 127 389 403.0 0BZ:1 Type1 Inactive DFGinter 5.9852 8.919 None -84.43, -63.71 55.14, -138.06 56.46, -120.92 215.0, 157.19 -49.66, 129.46 out-out out 11.6396 Saltbr-out 8.5001 HRD-out 65.25, 47.84 -72.14, 146.01 out-out-out SNCooo out-out ActLoopNT-out 17.1541 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 99.26, -2.89 APE9-dihe-na -90.04, 20.41 APE8-dihe-out -81.04, -73.69 APE8-rot-out 50.59 APE67-dihe-in -55.45, -35.38 -82.74, -1.38 APE12-dist-out 14.5607 APE11-dist-in 10.842 APE10-dist-out 15.9499 APE9-dist-out 14.036 T287D None None XRAY 2.8 0.231 0.278 B 279.0 263.0 0 26 26 0 [[133, 383]] 1.0 3unz Homo sapiens CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3UO6A O14965 126 389 403.0 0BY:1 Type1 Inactive DFGinter 6.0888 8.9465 None -92.08, -63.22 55.79, -136.4 58.35, -117.73 204.46, 160.17 -58.84, 166.86 out-out out 11.3025 Saltbr-out 11.4219 HRD-out 44.35, 72.76 -98.46, 135.56 out-out-out SNCooo out-out ActLoopNT-out 17.2272 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 76.96, -17.98 APE9-dihe-na -113.29, 10.31 APE8-dihe-out -74.35, -72.68 APE8-rot-out 36.75 APE67-dihe-in -49.94, -38.95 -75.25, -15.59 APE12-dist-out 14.6421 APE11-dist-in 12.2047 APE10-dist-out 16.5919 APE9-dist-out 14.1631 T287D None None XRAY 2.8 0.229 0.276 A 279.0 264.0 0 26 26 0 [[133, 383]] 1.0 3uo6 Homo sapiens CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3UO6B O14965 126 389 403.0 0BY:2 Type1 Inactive DFGinter 6.0878 8.9354 None -92.34, -63.27 55.7, -136.72 58.91, -118.35 204.74, 161.14 -58.96, 166.79 out-out out 11.2723 Saltbr-out 11.476 HRD-out 44.24, 73.02 -98.37, 136.49 out-out-out SNCooo out-out ActLoopNT-out 17.2321 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 75.5, -18.28 APE9-dihe-na -114.49, 10.92 APE8-dihe-out -74.12, -73.35 APE8-rot-out 38.72 APE67-dihe-in -50.19, -38.98 -73.97, -15.63 APE12-dist-out 14.6515 APE11-dist-in 12.2094 APE10-dist-out 16.5925 APE9-dist-out 14.1537 T287D None None XRAY 2.8 0.229 0.276 B 279.0 264.0 0 26 26 0 [[133, 383]] 1.0 3uo6 Homo sapiens CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3UOHA O14965 126 389 403.0 0C4:2 Type1 Inactive DFGinter 6.0378 8.9143 None -93.18, -63.37 54.89, -130.23 58.47, -116.07 202.5, 1.54 -59.86, 169.88 out-out out 12.2033 Saltbr-out 10.6415 HRD-out 60.57, 51.18 -70.61, 154.26 out-out-out SNCooo out-out ActLoopNT-out 17.2971 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 97.37, -1.48 APE9-dihe-na -94.0, 16.64 APE8-dihe-out -73.09, -72.62 APE8-rot-out 34.55 APE67-dihe-in -54.13, -35.68 -91.14, -1.84 APE12-dist-out 14.3491 APE11-dist-in 11.496 APE10-dist-out 16.5595 APE9-dist-out 14.0026 T287D None None XRAY 2.8 0.23 0.288 A 279.0 264.0 0 26 26 0 [[133, 383]] 1.0 3uoh Homo sapiens CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3UOHB O14965 126 389 403.0 0C4:1 Type1 Inactive DFGinter 6.0345 8.9001 None -93.16, -63.34 54.68, -130.86 58.94, -116.29 202.73, 0.89 -60.04, 170.49 out-out out 12.2519 Saltbr-out 10.4593 HRD-out 56.43, 52.93 -71.71, 154.95 out-out-out SNCooo out-out ActLoopNT-out 17.2863 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 97.52, -1.59 APE9-dihe-na -93.94, 16.64 APE8-dihe-out -72.82, -72.33 APE8-rot-out 34.94 APE67-dihe-in -54.2, -36.03 -91.21, -1.67 APE12-dist-out 14.3532 APE11-dist-in 11.5068 APE10-dist-out 16.5755 APE9-dist-out 14.0104 T287D None None XRAY 2.8 0.23 0.288 B 279.0 264.0 0 26 26 0 [[133, 383]] 1.0 3uoh Homo sapiens CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3UOJA O14965 127 389 403.0 0C5:1 Type1 Inactive DFGinter 6.2496 8.6517 None -89.03, -64.22 49.6, -140.48 55.65, -113.8 181.43, 6.66 -48.52, 138.84 out-out out 12.9006 Saltbr-out 10.1671 HRD-out 77.34, -11.89 -40.57, 125.77 out-out-out SNCooo out-out ActLoopNT-out 16.7655 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 98.97, 1.26 APE9-dihe-na -102.25, -2.44 APE8-dihe-out -61.85, -58.87 APE8-rot-out 33.31 APE67-dihe-in -56.59, -30.78 -67.25, -33.49 APE12-dist-out 15.3881 APE11-dist-in 12.5887 APE10-dist-out 17.4172 APE9-dist-out 14.292 T287D None None XRAY 2.9 0.227 0.274 A 279.0 263.0 0 26 26 0 [[133, 383]] 1.0 3uoj Homo sapiens CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3UOJB O14965 127 389 403.0 0C5:2 Type1 Inactive DFGinter 6.2636 8.6447 None -88.87, -64.57 49.7, -140.5 55.59, -113.73 181.06, 6.55 -48.5, 138.54 out-out out 12.9094 Saltbr-out 10.1475 HRD-out 77.24, -11.84 -40.35, 125.95 out-out-out SNCooo out-out ActLoopNT-out 16.7603 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 98.86, 1.29 APE9-dihe-na -101.95, -2.75 APE8-dihe-out -62.17, -58.93 APE8-rot-out 33.01 APE67-dihe-in -57.8, -30.14 -66.39, -33.04 APE12-dist-out 15.3867 APE11-dist-in 12.5858 APE10-dist-out 17.4158 APE9-dist-out 14.2887 T287D None None XRAY 2.9 0.227 0.274 B 279.0 263.0 0 26 26 0 [[133, 383]] 1.0 3uoj Homo sapiens CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3UOKA O14965 125 389 403.0 0C6:2 Type1 Inactive DFGinter 5.7502 9.2837 None -87.48, -71.36 58.97, -135.37 54.65, -117.02 195.51, 34.07 -55.93, 122.72 out-out out 11.8975 Saltbr-out 12.9164 HRD-out 40.64, 72.07 -97.16, 132.51 out-out-out SNCooo out-out ActLoopNT-out 17.0984 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 75.79, -21.51 APE9-dihe-na -114.86, 8.46 APE8-dihe-out -81.91, -68.59 APE8-rot-out 58.99 APE67-dihe-in -48.81, -38.43 -66.52, -22.51 APE12-dist-out 14.1012 APE11-dist-in 12.2923 APE10-dist-out 16.9657 APE9-dist-out 14.8589 T287D None None XRAY 2.951 0.223 0.276 A 279.0 265.0 0 26 26 0 [[133, 383]] 1.0 3uok Homo sapiens CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3UOKB O14965 125 389 403.0 0C6:1 Type1 Inactive DFGinter 5.7492 9.2769 None -88.85, -71.53 59.08, -134.89 54.38, -116.99 195.48, 34.01 -56.06, 122.86 out-out out 11.8774 Saltbr-out 12.919 HRD-out 40.28, 71.92 -97.4, 131.84 out-out-out SNCooo out-out ActLoopNT-out 17.0785 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 75.7, -21.55 APE9-dihe-na -114.97, 8.84 APE8-dihe-out -82.0, -69.27 APE8-rot-out 58.99 APE67-dihe-in -49.23, -38.63 -66.58, -21.59 APE12-dist-out 14.0964 APE11-dist-in 12.283 APE10-dist-out 16.9628 APE9-dist-out 14.861 T287D None None XRAY 2.951 0.223 0.276 B 279.0 265.0 0 26 26 0 [[133, 383]] 1.0 3uok Homo sapiens CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3UOLA O14965 127 389 403.0 0C7:2 Type1 Inactive DFGinter 6.0688 8.6574 None -80.65, -49.91 38.66, -132.1 60.59, -110.72 197.86, 22.76 -76.74, 23.35 out-out out 13.7802 Saltbr-out 9.949 HRD-out 53.65, 45.58 -63.49, 138.74 out-out-out SNCooo out-out ActLoopNT-out 17.0956 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 91.11, -3.8 APE9-dihe-na -96.74, -20.87 APE8-dihe-out -56.71, -68.79 APE8-rot-out 61.79 APE67-dihe-in -54.04, -24.57 -47.13, -38.35 APE12-dist-out 15.1122 APE11-dist-in 13.7844 APE10-dist-out 17.7242 APE9-dist-out 14.4029 T287D None None XRAY 2.4 0.237 0.283 A 279.0 263.0 0 26 26 0 [[133, 383]] 1.0 3uol Homo sapiens CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3UOLB O14965 127 389 403.0 0C7:1 Type1 Inactive DFGinter 5.9903 8.6597 None -80.74, -49.45 38.08, -131.75 60.44, -110.58 198.19, 22.88 -77.08, 23.2 out-out out 13.7763 Saltbr-out 9.9593 HRD-out 54.22, 44.36 -62.05, 139.57 out-out-out SNCooo out-out ActLoopNT-out 17.0935 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 91.25, -3.95 APE9-dihe-na -95.92, -22.22 APE8-dihe-out -56.1, -68.18 APE8-rot-out 62.15 APE67-dihe-in -54.2, -24.78 -47.47, -38.07 APE12-dist-out 15.1229 APE11-dist-in 13.7913 APE10-dist-out 17.7315 APE9-dist-out 14.3906 T287D None None XRAY 2.4 0.237 0.283 B 279.0 263.0 0 26 26 0 [[133, 383]] 1.0 3uol Homo sapiens CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3FDNA O14965 126 394 403.0 MMH:1 Type1 Inactive DFGinter 5.8355 8.6997 None -113.83, -12.3 -83.93, 150.0 -89.96, 27.39 288.28, 8.62 -77.57, 62.14 out-out out 12.1684 Saltbr-out 8.3471 HRD-out -96.45, 141.44 -71.53, -154.43 out-out-out SNCooo out-out ActLoopNT-out 5.673 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -102.73 APE9-dihe-na 114.27, 146.94 APE8-dihe-in -67.7, 139.44 APE8-rot-in 273.96 APE67-dihe-in -48.36, -34.0 -88.05, -6.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.5747 APE9-dist-out 13.3401 T288D None None XRAY 1.9 0.231 0.287 A 279.0 261.0 8 26 18 8 [[133, 383]] 1.0 3fdn Homo sapiens CAMK_AURKA_HUMAN CAMK 1.6e-79 272.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3K5UA O14965 126 394 403.0 PFQ:1001 Type1 Inactive DFGinter 5.7075 8.8247 None -107.52, -18.97 -91.45, 151.1 -94.09, 23.54 298.73, 177.78 -72.02, 54.86 out-out out 12.1242 Saltbr-out 8.7194 HRD-out -88.39, 148.19 -76.48, -155.88 out-out-out SNCooo out-out ActLoopNT-out 5.3654 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -121.1 APE9-dihe-na 103.03, 152.44 APE8-dihe-in -66.2, 143.09 APE8-rot-in 275.11 APE67-dihe-in -49.38, -31.53 -92.54, -7.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.4606 APE9-dist-out 13.4355 T288D None None XRAY 2.35 0.242 0.26 A 279.0 260.0 9 26 17 9 [[133, 383]] 1.0 3k5u Homo sapiens CAMK_AURKA_HUMAN CAMK 1.6e-79 272.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4JBQA O14965 126 391 403.0 VX6:501 Type1 Inactive DFGinter 5.8629 8.9774 None -117.17, -3.86 -81.51, -172.59 -125.34, 20.35 277.47, 29.16 -74.78, 56.29 out-out out 12.3249 Saltbr-out 9.4595 HRD-out -106.24, 150.32 -82.52, -162.88 out-out-out SNCooo out-out ActLoopNT-out 5.4198 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 124.19 APE9-dihe-na 110.15, 136.99 APE8-dihe-in -65.42, 141.32 APE8-rot-out 182.94 APE67-dihe-in -48.15, -34.26 -90.56, -13.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.7182 APE9-dist-out 13.3126 T288D None None XRAY 2.3 0.227 0.282 A 279.0 257.0 9 26 17 9 [[133, 383]] 1.0 4jbq Homo sapiens CAMK_AURKA_HUMAN CAMK 1.6e-79 272.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3LAUA O14965 125 391 403.0 OFI:60001 Type1 Inactive DFGinter 4.8739 9.4699 None -122.68, 72.55 -135.5, 105.71 -124.13, 999.0 233.96, 104.58 999.0, 999.0 out-out out 11.6122 Saltbr-out 10.8505 HRD-out 60.88, 64.76 -92.19, 140.49 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.81, -17.37 999.0, -42.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T288D None None XRAY 2.1 0.203 0.248 A 287.0 250.0 17 26 9 17 [[133, 383]] 1.0 3lau Homo sapiens CAMK_AURKA_HUMAN CAMK 1.8e-79 272.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4UZHA O14965 125 392 403.0 JVE:61392 Type1 Inactive DFGinter 6.1645 8.8467 None -134.4, 63.5 -102.61, 61.53 -163.5, 999.0 153.81, 66.79 999.0, 999.0 out-out out 11.6163 Saltbr-out 7.1967 HRD-out 56.64, 70.94 -95.92, 131.49 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.98, -11.66 999.0, -76.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.205 0.235 A 287.0 251.0 17 26 9 17 [[133, 383]] 1.0 4uzh Homo sapiens CAMK_AURKA_HUMAN CAMK 1.8e-79 272.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3H0YA O14965 126 388 403.0 48B:1 Type1 Inactive DFGinter 6.252 8.4177 None -109.47, -26.38 -75.33, 137.27 -77.12, 162.45 293.82, 171.84 -85.27, 155.38 out-out out 11.7561 Saltbr-out 8.4071 HRD-out -128.83, 133.48 -56.66, -46.86 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 129.6 APE8-rot-out 181.19 APE67-dihe-in -47.87, -33.3 -84.26, -9.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K124A,T287A,T288A None None XRAY 2.5 0.216 0.285 A 268.0 250.0 13 26 13 13 [[133, 383]] 1.0 3h0y Homo sapiens CAMK_AURKA_HUMAN CAMK 3.9e-79 271.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3H10A O14965 124 391 403.0 97B:1 Type1 Inactive DFGinter 5.9492 9.2917 None -85.74, 156.36 -96.9, 153.5 66.79, 45.29 317.78, 104.47 -57.91, -32.92 out-out out 11.6847 Saltbr-out 10.3175 HRD-out 59.2, 41.52 -65.77, 140.34 out-out-out SNCooo out-out ActLoopNT-out 17.4337 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -128.56, 51.89 APE9-dihe-na 117.04, -170.29 APE8-dihe-in -90.19, 120.52 APE8-rot-in 294.83 APE67-dihe-in -57.04, -32.9 -46.43, -51.7 APE12-dist-in 10.2759 APE11-dist-out 14.6013 APE10-dist-out 13.5368 APE9-dist-out 10.4758 K124A,T287A,T288A None None XRAY 2.2 0.197 0.24 A 268.0 268.0 0 26 26 0 [[133, 383]] 1.0 3h10 Homo sapiens CAMK_AURKA_HUMAN CAMK 3.9e-79 271.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3H10B O14965 125 391 403.0 97B:2 Type1 Inactive DFGinter 6.0858 9.0997 None -84.1, 155.64 -96.32, 147.85 67.68, 47.0 313.1, 101.31 -64.96, -29.8 out-out out 11.3478 Saltbr-out 9.7368 HRD-out 52.62, 55.73 -75.29, 145.84 out-out-out SNCooo out-out ActLoopNT-out 17.5945 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -164.73, 70.51 APE9-dihe-na 110.59, 173.85 APE8-dihe-in -85.08, 117.86 APE8-rot-in 292.57 APE67-dihe-in -65.77, -24.94 -40.25, -55.5 APE12-dist-in 10.3774 APE11-dist-out 14.4906 APE10-dist-out 13.0909 APE9-dist-out 10.6735 K124A,T287A,T288A None None XRAY 2.2 0.197 0.24 B 268.0 267.0 0 26 26 0 [[133, 383]] 1.0 3h10 Homo sapiens CAMK_AURKA_HUMAN CAMK 3.9e-79 271.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3H10D O14965 126 388 403.0 97B:3 Type1 Inactive DFGinter 5.6519 9.3506 None -78.35, 156.2 -102.03, 146.36 61.53, 46.31 320.5, 110.27 -53.35, -35.87 out-out out 12.2711 Saltbr-out 10.4052 HRD-out 47.1, 36.06 -65.28, 120.88 out-out-none SNCoon out-none ActLoopNT-out 16.9329 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 130.75 APE8-rot-in 285.65 APE67-dihe-in -49.42, -30.99 -50.38, -44.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K124A,T287A,T288A None None XRAY 2.2 0.197 0.24 D 268.0 255.0 8 26 18 8 [[133, 383]] 1.0 3h10 Homo sapiens CAMK_AURKA_HUMAN CAMK 3.9e-79 271.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3P9JA O14965 126 388 403.0 P9J:1 Type1 Inactive DFGinter 6.8837 7.9415 None -102.4, -6.03 -81.85, 156.26 -90.38, 17.14 289.53, 9.94 -77.54, 34.79 out-out out 12.3724 Saltbr-out 9.8794 HRD-out -106.04, 150.63 -81.01, -161.23 out-out-out SNCooo out-out ActLoopNT-out 5.3497 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 98.73 APE8-dihe-in -129.65, 90.21 APE8-rot-out 170.24 APE67-dihe-in -44.1, -38.87 -140.2, 19.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.1027 T287A,T288A None None XRAY 2.8 0.204 0.271 A 268.0 249.0 14 26 15 11 [[133, 383]] 1.0 3p9j Homo sapiens CAMK_AURKA_HUMAN CAMK 3.9e-79 271.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3W10A O14965 126 388 403.0 RO9:501 Type1 Inactive DFGinter 6.3733 9.6946 None -119.04, 54.38 -98.61, 30.05 -138.73, 164.74 58.12, 85.11 47.87, 16.56 out-out out 11.8006 Saltbr-out 10.3331 HRD-out 62.97, 65.74 -95.42, 130.99 out-out-out SNCooo out-out ActLoopNT-out 17.4801 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -81.52, 14.87 APE9-dihe-na -42.97, -40.22 APE8-dihe-out -121.83, 17.25 APE8-rot-out 76.19 APE67-dihe-in -68.64, -18.29 -61.37, -40.89 APE12-dist-in 9.7517 APE11-dist-out 14.7144 APE10-dist-out 16.0551 APE9-dist-out 11.7746 T287A,T288A None None XRAY 2.7 0.249 0.309 A 278.0 263.0 0 26 26 0 [[133, 383]] 1.0 3w10 Homo sapiens CAMK_AURKA_HUMAN CAMK 4.4e-79 271.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3R22A O14965 126 389 403.0 D37:1 Type1 Inactive DFGinter 6.4723 8.5569 None -142.77, -34.51 -91.78, -141.21 -154.74, 60.2 276.78, 88.9 -152.2, 21.14 out-out out 11.924 Saltbr-out 7.8942 HRD-out -77.07, 147.44 -101.45, -61.81 out-out-out SNCooo out-out ActLoopNT-out 4.7862 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 163.54 APE8-dihe-in -57.16, 146.3 APE8-rot-out 184.12 APE67-dihe-in -47.8, -31.62 -95.89, 1.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.996 T287D,T288D None None XRAY 2.9 0.271 0.313 A 271.0 255.0 9 26 17 9 [[133, 383]] 1.0 3r22 Homo sapiens CAMK_AURKA_HUMAN CAMK 1.8e-79 272.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 9KDSA O14965 126 391 403.0 A1EFT:220 Type1 Inactive DFGinter 5.8406 9.0606 None -115.36, -22.96 -73.25, 150.65 -96.11, 14.3 285.47, 2.42 -64.22, 74.88 out-out out 12.2623 Saltbr-out 9.1038 HRD-out -98.78, 149.89 -79.07, -155.21 out-out-out SNCooo out-out ActLoopNT-out 5.2001 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -139.65 APE8-dihe-in -67.03, 136.06 APE8-rot-in 265.66 APE67-dihe-in -47.15, -28.7 -90.01, -5.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.6429 C290A None A1EFT220 XRAY 2.5 0.217 0.253 A 266.0 257.0 9 26 17 9 [[133, 383]] 1.0 9kds Homo sapiens CAMK_AURKA_HUMAN CAMK 1e-78 270.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2BMCA O14965 127 394 403.0 MPY:1395 Type1 Inactive DFGinter 6.5807 8.6492 None -120.22, 2.69 -79.74, 177.87 -120.44, 28.65 279.36, 74.44 -63.39, 54.99 out-out out 12.7119 Saltbr-out 9.6481 HRD-out -124.67, 146.35 -86.18, -146.55 out-out-out SNCooo out-out ActLoopNT-out 5.3993 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -132.56 APE8-rot-out 47.16 APE67-dihe-in -49.36, -30.39 -47.35, -35.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.228 0.252 A 306.0 256.0 12 26 14 12 [[133, 383]] 1.0 2bmc Homo sapiens CAMK_AURKA_HUMAN CAMK 2.8e-79 272.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2BMCB O14965 125 394 403.0 MPY:1395 Type1 Inactive DFGinter 6.807 8.5295 None -121.32, 0.27 -78.21, 179.92 -122.08, 26.9 281.74, 72.08 -64.82, 57.86 out-out out 12.7424 Saltbr-out 9.3491 HRD-out -129.07, 147.12 -89.63, -143.13 out-out-out SNCooo out-out ActLoopNT-out 5.3349 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -148.66 APE8-rot-out 47.86 APE67-dihe-in -45.98, -40.8 -48.24, -32.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.228 0.252 B 306.0 258.0 12 26 14 12 [[133, 383]] 1.0 2bmc Homo sapiens CAMK_AURKA_HUMAN CAMK 2.8e-79 272.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2BMCC O14965 125 393 403.0 MPY:1394 Type1 Inactive DFGinter 6.84 8.5631 None -111.71, -8.17 -78.0, 176.81 -119.82, 27.04 283.62, 65.51 -62.65, 57.16 out-out out 12.7588 Saltbr-out 9.2905 HRD-out -129.54, 151.84 -86.76, -144.72 out-out-out SNCooo out-out ActLoopNT-out 5.4531 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -175.11 APE8-rot-out 45.5 APE67-dihe-in -27.05, -38.79 -54.18, -36.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.228 0.252 C 306.0 257.0 12 26 14 12 [[133, 383]] 1.0 2bmc Homo sapiens CAMK_AURKA_HUMAN CAMK 2.8e-79 272.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2BMCD O14965 127 394 403.0 MPY:1395 Type1 Inactive DFGinter 6.7974 8.666 None -115.73, -0.95 -79.88, 179.36 -120.07, 22.55 284.5, 74.5 -63.99, 59.56 out-out out 12.6807 Saltbr-out 9.214 HRD-out -128.93, 150.36 -86.55, -146.18 out-out-out SNCooo out-out ActLoopNT-out 5.4478 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -170.43 APE8-rot-out 54.46 APE67-dihe-in -29.4, -31.11 -37.9, -57.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.228 0.252 D 306.0 256.0 12 26 14 12 [[133, 383]] 1.0 2bmc Homo sapiens CAMK_AURKA_HUMAN CAMK 2.8e-79 272.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2BMCE O14965 127 394 403.0 MPY:1395 Type1 Inactive DFGinter 6.8258 8.4887 None -115.38, -3.61 -77.32, 179.54 -120.22, 21.67 284.65, 76.22 -63.51, 61.05 out-out out 12.6416 Saltbr-out 9.4342 HRD-out -126.37, 151.8 -84.41, -148.69 out-out-out SNCooo out-out ActLoopNT-out 5.4524 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -151.66 APE8-rot-out 63.51 APE67-dihe-in -26.62, -34.28 -40.09, -60.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.228 0.252 E 306.0 256.0 12 26 14 12 [[133, 383]] 1.0 2bmc Homo sapiens CAMK_AURKA_HUMAN CAMK 2.8e-79 272.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2BMCF O14965 126 394 403.0 MPY:1395 Type1 Inactive DFGinter 6.5085 8.8222 None -115.69, -5.93 -78.56, 177.32 -122.14, 28.38 282.23, 67.06 -65.82, 60.75 out-out out 12.7531 Saltbr-out 9.2711 HRD-out -127.86, 148.46 -84.63, -148.84 out-out-out SNCooo out-out ActLoopNT-out 5.4126 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -159.21 APE8-rot-out 48.76 APE67-dihe-in -12.19, -42.56 -50.87, -58.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.228 0.252 F 306.0 257.0 12 26 14 12 [[133, 383]] 1.0 2bmc Homo sapiens CAMK_AURKA_HUMAN CAMK 2.8e-79 272.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 7FICA O14965 127 391 403.0 5YZ:401 Type1 Inactive DFGinter 6.6562 8.6983 None -127.87, 74.52 -84.56, 58.76 -143.59, 98.4 223.5, 108.01 121.48, 144.52 out-none out 11.4309 Saltbr-none 999.0 HRD-out -142.2, 146.4 -144.31, 136.82 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 142.56 APE9-dihe-na -122.69, 31.13 APE8-dihe-out -54.83, -47.63 APE8-rot-out 52.3 APE67-dihe-in -64.7, -30.85 -67.62, -21.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.1675 APE9-dist-out 15.1036 C290A None None XRAY 2.32 0.237 0.274 A 265.0 254.0 11 26 15 11 [[133, 383]] 1.0 7fic Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 9BZGA O14965 127 388 403.0 OG0:501 Type1 Inactive DFGinter 5.5742 8.9545 None -138.21, 40.41 -80.38, -6.22 -58.44, 128.99 169.82, 66.7 87.71, 11.81 out-out out 12.011 Saltbr-out 11.35 HRD-out 57.43, 61.28 -82.68, 137.68 out-out-out SNCooo out-out ActLoopNT-out 16.9054 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -68.5, -47.56 APE9-dihe-na -63.47, -40.24 APE8-dihe-out -67.43, -41.81 APE8-rot-in 291.8 APE67-dihe-in -55.03, -25.33 -61.13, -40.77 APE12-dist-in 8.031 APE11-dist-in 12.1759 APE10-dist-out 14.8132 APE9-dist-out 11.6538 C290A,C393S TPO288 TPO288 XRAY 1.8 0.188 0.22 A 285.0 262.0 0 26 26 0 [[133, 383]] 1.0 9bzg Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 9BZLB O14965 127 388 403.0 OGR:501 Type1 Inactive DFGinter 5.6518 8.9243 None -136.55, 35.09 -77.99, -4.99 -64.56, 136.29 165.56, 68.13 84.66, 11.21 out-out out 12.1448 Saltbr-out 11.5085 HRD-out 58.91, 63.34 -81.19, 137.19 out-out-out SNCooo out-out ActLoopNT-out 16.8417 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -64.8, -45.23 APE9-dihe-na -65.62, -37.14 APE8-dihe-out -65.61, -42.19 APE8-rot-in 287.26 APE67-dihe-in -56.13, -23.23 -60.59, -40.07 APE12-dist-in 8.118 APE11-dist-in 11.6758 APE10-dist-out 14.6215 APE9-dist-out 11.7014 C290A,C393S TPO288 TPO288 XRAY 1.81 0.192 0.214 B 285.0 262.0 0 26 26 0 [[133, 383]] 1.0 9bzl Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 9KS6A O14965 127 391 403.0 A1EG1:162 Type1 Inactive DFGinter 5.888 9.1061 None -147.81, 30.43 -100.08, -15.16 61.73, 18.3 290.83, 10.75 -77.9, 72.48 out-na out 12.4716 Saltbr-na 9.13 HRD-out -111.85, 134.04 -63.11, -66.03 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 127.23 APE8-rot-in 299.78 APE67-dihe-in -48.85, -29.53 -94.69, -1.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None A1EG1162 XRAY 2.75 0.232 0.267 A 265.0 251.0 14 26 12 14 [[133, 383]] 1.0 9ks6 Homo sapiens CAMK_AURKA_HUMAN CAMK 2.5e-78 268.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4ZTQA O14965 127 388 403.0 4RM:501 Type1.5_Back Inactive DFGinter 9.794 7.5502 None -128.95, 86.44 -158.65, -177.96 -107.17, 35.48 297.86, 94.26 -105.4, 22.98 out-out out 11.7775 Saltbr-out 13.1482 HRD-out -111.76, 156.87 -90.96, -144.93 out-out-out SNCooo out-out ActLoopNT-out 5.2656 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -178.64 APE8-dihe-in -81.15, 143.47 APE8-rot-out 185.07 APE67-dihe-in -33.25, -44.07 -77.96, -26.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.9414 None None None XRAY 2.8 0.203 0.246 A 285.0 247.0 15 26 15 11 [[133, 383]] 1.0 4ztq Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4ZTSA O14965 127 388 403.0 4RK:501 Type1.5_Back Inactive DFGinter 9.8568 7.6116 None -142.98, 93.02 -162.47, -179.72 -105.27, 64.86 290.53, 116.01 159.83, 107.65 out-out out 12.2378 Saltbr-out 12.5393 HRD-out -124.72, 145.07 -84.3, -151.71 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 133.6 APE8-rot-out 180.3 APE67-dihe-in -43.16, -25.38 -86.65, -10.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.213 0.249 A 285.0 249.0 13 26 13 13 [[133, 383]] 1.0 4zts Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3EFWA O14965 126 388 403.0 AK8:404 Type1.5_Front Inactive DFGinter 6.1659 9.1924 None -114.69, 29.1 -93.31, 98.64 -72.68, 999.0 277.06, 45.29 999.0, 999.0 out-none out 12.5044 Saltbr-none 999.0 HRD-out -100.96, 129.93 -74.44, -133.77 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -49.97, -16.9 999.0, -48.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.29 0.26 0.295 A 267.0 240.0 23 26 9 17 [[133, 383]] 1.0 3efw Homo sapiens CAMK_AURKA_HUMAN CAMK 6e-80 274.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3EFWB O14965 126 389 403.0 AK8:404 Type1.5_Front Inactive DFGinter 6.8431 8.7182 None -97.71, -18.22 -58.8, 127.67 -71.64, 999.0 297.41, 150.5 999.0, 999.0 out-out out 12.831 Saltbr-out 9.7516 HRD-out -122.37, 142.08 -72.73, -61.12 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -56.59, -24.0 999.0, -41.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.29 0.26 0.295 B 267.0 242.0 22 26 9 17 [[133, 383]] 1.0 3efw Homo sapiens CAMK_AURKA_HUMAN CAMK 6e-80 274.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3O50A O14965 126 388 403.0 LJE:1 Type1.5_Front Inactive DFGinter 6.9257 8.5897 None -120.45, 57.47 -126.6, 83.94 -51.28, 45.89 305.79, 65.53 -47.9, 167.61 out-out out 12.7711 Saltbr-out 9.6877 HRD-out -105.95, -54.24 71.67, 50.89 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.18 APE8-rot-out 177.59 APE67-dihe-in -53.46, -33.48 -54.98, -22.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.285 0.351 A 267.0 246.0 17 26 12 14 [[133, 383]] 1.0 3o50 Homo sapiens CAMK_AURKA_HUMAN CAMK 6e-80 274.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3O50B O14965 126 389 403.0 LJE:1 Type1.5_Front Inactive DFGinter 7.1294 8.8014 None -108.79, 36.5 -105.08, 99.13 -72.4, 999.0 308.79, 175.58 999.0, 999.0 out-out out 12.8682 Saltbr-out 9.6362 HRD-out -123.96, 166.98 -117.96, 27.18 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -123.8, 136.42 APE9-dihe-na -70.48, -112.85 APE8-dihe-in -82.24, 115.2 APE8-rot-out 163.63 APE67-dihe-in -35.05, -31.99 -65.91, -24.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.3267 None None None XRAY 2.0 0.285 0.351 B 267.0 249.0 15 26 15 11 [[133, 383]] 1.0 3o50 Homo sapiens CAMK_AURKA_HUMAN CAMK 6e-80 274.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 6HJJA O14965 127 393 403.0 G7T:501 Type1.5_Front Inactive DFGinter 6.251 8.4927 None -112.85, -19.21 -86.09, 145.25 -81.54, -160.25 301.92, 166.71 41.76, 103.89 out-out out 12.3082 Saltbr-out 9.3111 HRD-out -108.67, 152.78 -84.21, -142.85 out-out-out SNCooo out-out ActLoopNT-out 5.7023 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.9 APE8-dihe-in -60.46, 140.32 APE8-rot-out 182.81 APE67-dihe-in -42.69, -33.03 -85.17, -13.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.2199 L210C,C290A,C393A None None XRAY 2.13 0.212 0.269 A 285.0 256.0 11 26 15 11 [[133, 383]] 1.0 6hjj Homo sapiens CAMK_AURKA_HUMAN CAMK 4.1e-78 268.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2C6EA O14965 127 389 403.0 HPM:61389 Type1.5_Back Inactive DFGout 13.8284 10.5042 BBAminus -107.5, 166.44 -107.98, 77.13 -86.33, -35.22 287.99, 100.84 -90.9, 43.1 out-out out 12.2357 Saltbr-out 11.4051 HRD-in -84.92, -60.14 72.68, 11.22 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 89.24 APE8-dihe-in -59.23, 168.18 APE8-rot-out 37.94 APE67-dihe-in -43.87, -36.15 -54.57, -39.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.3931 None None None XRAY 2.1 0.2 0.27 A 283.0 251.0 12 26 14 12 [[133, 383]] 1.0 2c6e Homo sapiens CAMK_AURKA_HUMAN CAMK 1.7e-79 272.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 6VPJA O14965 104 389 403.0 ANP:60401 ATPlike Inactive DFGout 12.8705 10.5737 None -110.21, 156.22 -91.65, 36.01 -66.52, 152.83 298.69, 154.8 77.13, 20.04 out-out out 11.1099 Saltbr-out 9.2857 HRD-out -138.11, 171.42 -106.7, -171.48 out-out-out SNCooo out-out ActLoopNT-out 12.6593 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -97.02, 1.42 APE9-dihe-na 78.4, 140.83 APE8-dihe-out -96.06, -166.39 APE8-rot-out 60.44 APE67-dihe-in -59.33, -27.82 -96.84, 6.17 APE12-dist-in 11.6479 APE11-dist-in 13.2558 APE10-dist-out 10.9109 APE9-dist-out 17.2151 None None None XRAY 2.1 0.192 0.215 A 292.0 263.0 3 26 23 3 [[133, 383]] 1.0 6vpj Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 6VPHA O14965 7 389 403.0 ANP:60604 ATPlike Inactive DFGout 13.6713 11.5565 None -98.71, -169.93 -135.39, 50.18 -66.9, 153.36 295.81, 141.3 65.48, 29.39 out-out out 11.3786 Saltbr-out 9.7752 HRD-out -105.53, 132.54 -112.81, 142.85 out-out-out SNCooo out-out ActLoopNT-out 14.5801 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na -129.35, -34.6 APE9-dihe-na -51.22, -37.08 APE8-dihe-out -65.53, -18.81 APE8-rot-out 65.19 APE67-dihe-in -56.69, -28.96 -65.95, -34.72 APE12-dist-out 14.7601 APE11-dist-in 9.582 APE10-dist-out 12.2573 APE9-dist-out 21.2222 None TPO287,TPO288 CAS247,TPO287,TPO288,CAS290 XRAY 2.14 0.189 0.216 A 292.0 267.0 0 26 26 0 [[133, 383]] 1.0 6vph Homo sapiens CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4JAIA O14965 126 390 403.0 XU2:401 Type1 Inactive DFGout 13.4027 10.2629 None -152.02, 87.23 -129.85, 140.53 -120.2, 999.0 47.34, 110.12 999.0, 999.0 out-out out 12.2973 Saltbr-out 11.3549 HRD-out 48.66, 43.27 -47.21, 145.24 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 116.6 APE8-rot-none 999.0 APE67-dihe-out -39.38, -34.35 148.2, -90.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.231 0.318 A 284.0 249.0 16 26 10 16 [[133, 383]] 1.0 4jai Homo sapiens CAMK_AURKA_HUMAN CAMK 7.6e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 7AYHA O14965 125 390 403.0 S9H:501 Type1 Inactive DFGout 13.2217 10.4516 None -95.37, 143.61 -150.54, 155.43 -134.42, 999.0 174.18, 77.34 999.0, 999.0 out-out out 11.6983 Saltbr-out 8.8043 HRD-out -139.13, 166.73 -120.69, -52.37 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -40.89 APE8-rot-out 55.24 APE67-dihe-in -44.53, -29.55 -58.37, -31.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.275 0.313 A 285.0 250.0 16 26 10 16 [[133, 383]] 1.0 7ayh Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 7O2VA O14965 117 390 403.0 V0K:501 Type1 Inactive DFGout 12.6363 13.6464 None -115.24, -11.79 -83.13, 152.19 -88.8, 25.64 80.27, 118.54 -80.07, 61.89 out-out out 12.5796 Saltbr-out 11.4396 HRD-out -97.73, 141.11 -72.32, -153.11 out-out-out SNCooo out-out ActLoopNT-out 5.824 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -102.92 APE9-dihe-na 47.32, -129.13 APE8-dihe-in -68.33, 139.24 APE8-rot-in 291.4 APE67-dihe-in -46.53, -31.36 -88.23, -5.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.9763 APE9-dist-out 12.3162 None None None XRAY 3.1 0.275 0.329 A 299.0 264.0 10 26 16 10 [[133, 383]] 1.0 7o2v Homo sapiens CAMK_AURKA_HUMAN CAMK 9.1e-80 273.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3O51A O14965 126 388 403.0 LJF:1 Type1.5_Front Inactive DFGout 12.9209 9.2148 None -125.94, 46.56 -78.14, 156.47 -164.09, 999.0 59.42, 112.33 999.0, 999.0 out-none out 12.8625 Saltbr-none 999.0 HRD-out -126.02, 153.87 -92.88, -115.51 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -57.91, -10.7 999.0, -51.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.288 0.304 A 267.0 246.0 17 26 9 17 [[133, 383]] 1.0 3o51 Homo sapiens CAMK_AURKA_HUMAN CAMK 6e-80 274.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 6HJKA O14965 127 391 403.0 G7W:501 Type1.5_Front Inactive DFGout 16.1697 11.0281 None -98.89, -43.18 56.05, 51.38 -26.46, 122.09 241.09, 49.93 -75.8, 146.41 out-none out 11.5126 Saltbr-none 999.0 HRD-out -101.06, -164.07 153.73, -179.93 none-out-out SNCnoo out-out ActLoopNT-out 20.1842 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -66.21 APE9-dihe-na -150.91, 1.99 APE8-dihe-out -109.25, 19.55 APE8-rot-in 313.76 APE67-dihe-in -56.8, -21.9 -54.42, -38.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.6518 APE9-dist-out 13.8287 L210C,C290A,C393A None None XRAY 2.4 0.219 0.252 A 285.0 255.0 10 26 16 10 [[133, 383]] 1.0 6hjk Homo sapiens CAMK_AURKA_HUMAN CAMK 4.1e-78 268.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 6C83A O14965 127 389 403.0 ACP:501 ATPlike Inactive None 999.0 999.0 None -115.58, 146.0 -134.74, 164.64 -155.95, 999.0 999.0, 999.0 999.0, 999.0 out-none out 12.2939 Saltbr-none 999.0 HRD-out 57.31, 86.65 -118.52, 133.44 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -76.52 APE8-dihe-out -81.29, 5.34 APE8-rot-out 166.86 APE67-dihe-in -68.45, -16.44 -75.67, -23.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.2563 None None None XRAY 2.55 0.268 0.322 A 285.0 248.0 15 26 11 15 [[133, 383]] 1.0 6c83 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2WQEA O14965 127 388 403.0 ADP:1389,ADP:1390,ADP:1391 ATPlike,ATPlike,ATPlike Inactive None 999.0 999.0 None -107.12, -44.35 28.24, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 12.4276 Saltbr-none 999.0 HRD-out -82.99, 160.23 -97.32, -44.1 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -56.47 APE8-dihe-out -79.62, -22.51 APE8-rot-in 267.0 APE67-dihe-in -40.62, -26.16 -46.48, -55.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.7962 S155R None None XRAY 2.5 0.206 0.251 A 262.0 241.0 21 26 10 16 [[133, 383]] 1.0 2wqe Homo sapiens CAMK_AURKA_HUMAN CAMK 9.7e-80 273.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 5OBRA O14965 126 390 403.0 9QT:401,SKE:402 Allosteric,Type1 Inactive None 11.9936 14.1133 None -120.85, 175.9 49.64, 111.5 91.55, -154.11 257.58, 58.97 124.57, 54.88 out-out out 11.6699 Saltbr-out 7.51 HRD-in -87.06, -37.27 63.65, 5.21 out-out-out SNCooo out-out ActLoopNT-out 5.706 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 174.71 APE8-dihe-in -48.88, 148.85 APE8-rot-out 188.4 APE67-dihe-in -53.11, -27.71 -92.05, -5.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6313 None None None XRAY 2.62 0.226 0.292 A 272.0 255.0 10 26 16 10 [[133, 383]] 1.0 5obr Homo sapiens CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3W2CC O14965 128 388 403.0 N15:401 Type1 Inactive None 999.0 999.0 None -119.65, 152.46 84.37, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 13.8507 Saltbr-out 14.4223 HRD-none 999.0, 999.0 999.0, 999.0 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -102.95 APE8-rot-in 346.67 APE67-dihe-in -33.77, -43.59 -64.85, -45.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.45 0.256 0.32 C 261.0 202.0 59 26 9 17 [[133, 383]] 1.0 3w2c Homo sapiens CAMK_AURKA_HUMAN CAMK 5.5e-80 274.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3W2CE O14965 128 388 403.0 N15:401 Type1 Inactive None 999.0 999.0 None -123.91, 159.82 65.31, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 12.9062 Saltbr-out 10.7606 HRD-none 999.0, 999.0 999.0, 999.0 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -62.35 APE8-rot-in 314.5 APE67-dihe-in -33.57, -39.05 -86.05, -41.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.45 0.256 0.32 E 261.0 202.0 59 26 9 17 [[133, 383]] 1.0 3w2c Homo sapiens CAMK_AURKA_HUMAN CAMK 5.5e-80 274.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2X81A O14965 127 388 403.0 ZZL:1389 Type1 Inactive None 999.0 999.0 None -101.61, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 11.6574 Saltbr-none 999.0 HRD-in -75.09, -52.06 78.45, -27.83 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -158.98 APE8-dihe-in -83.83, 140.8 APE8-rot-out 188.92 APE67-dihe-in -38.04, -33.42 -91.87, -17.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2972 None None None XRAY 2.91 0.247 0.303 A 272.0 242.0 20 26 9 17 [[133, 383]] 1.0 2x81 Homo sapiens CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3W18A O14965 126 388 403.0 N13:501 Type1 Inactive None 999.0 999.0 None -149.38, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 13.4813 Saltbr-out 16.091 HRD-out -82.01, 154.07 -81.44, -109.81 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -171.61 APE8-dihe-out -85.64, -13.77 APE8-rot-out 180.75 APE67-dihe-in -53.11, -25.2 -58.82, -47.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.9572 None None None XRAY 2.5 0.244 0.315 A 278.0 234.0 29 26 9 17 [[133, 383]] 1.0 3w18 Homo sapiens CAMK_AURKA_HUMAN CAMK 7e-80 274.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3W18B O14965 126 388 403.0 N13:501 Type1 Inactive None 999.0 999.0 None -134.47, -22.52 -99.45, 108.96 24.17, -97.42 999.0, 999.0 76.76, 11.53 none-none none 999.0 Saltbr-none 999.0 HRD-out -88.0, 136.09 -55.61, -107.06 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -45.74 APE8-dihe-out -74.68, -8.8 APE8-rot-out 190.63 APE67-dihe-in -49.12, -35.84 -75.77, -37.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.6107 None None None XRAY 2.5 0.244 0.315 B 278.0 236.0 27 26 13 13 [[133, 383]] 1.0 3w18 Homo sapiens CAMK_AURKA_HUMAN CAMK 7e-80 274.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4B0GA O14965 126 391 403.0 VEK:1392 Type1 Inactive None 999.0 999.0 None -124.76, 65.78 -126.11, 153.32 -100.51, 32.83 999.0, 999.0 -102.67, 15.93 out-out out 11.7537 Saltbr-out 9.485 HRD-out -122.36, 147.21 -84.03, -142.19 out-out-out SNCooo out-out ActLoopNT-out 5.3495 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.07 APE8-rot-out 159.6 APE67-dihe-in -43.66, -29.16 -52.83, -44.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.205 0.263 A 283.0 247.0 19 26 14 12 [[133, 383]] 1.0 4b0g Homo sapiens CAMK_AURKA_HUMAN CAMK 7.5e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 4BYJA O14965 126 388 403.0 FH5:1 Type1 Inactive None 999.0 999.0 None -109.39, 158.27 56.84, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 11.9983 Saltbr-out 7.845 HRD-out -133.37, 10.3 42.08, -54.53 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -4.7 APE8-rot-out 202.32 APE67-dihe-in -55.76, -21.63 -64.81, -35.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.232 0.248 A 285.0 246.0 17 26 9 17 [[133, 383]] 1.0 4byj Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3H0ZB O14965 126 388 403.0 45B:1 Type1 Inactive None 999.0 999.0 None -73.44, -144.2 -78.25, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 11.4286 Saltbr-out 6.8707 HRD-out 62.03, 82.81 -108.53, 139.38 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 101.15 APE8-rot-out 186.62 APE67-dihe-in -39.91, -40.23 -75.74, -20.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K124A,T287A,T288A None None XRAY 2.92 0.221 0.286 B 268.0 240.0 23 26 9 17 [[133, 383]] 1.0 3h0z Homo sapiens CAMK_AURKA_HUMAN CAMK 3.9e-79 271.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3H0ZC O14965 126 388 403.0 45B:1 Type1 Inactive None 999.0 999.0 None -154.11, 41.53 -98.85, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 12.8049 Saltbr-out 10.0054 HRD-out -67.65, 130.12 -81.39, -32.74 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 109.45 APE8-rot-out 167.45 APE67-dihe-in -45.08, -49.33 -107.53, 4.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K124A,T287A,T288A None None XRAY 2.92 0.221 0.286 C 268.0 246.0 17 26 9 17 [[133, 383]] 1.0 3h0z Homo sapiens CAMK_AURKA_HUMAN CAMK 3.9e-79 271.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3COHA O14965 128 388 403.0 83H:1 Type1 Inactive None 999.0 999.0 None -152.33, 69.84 -83.9, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 10.9213 Saltbr-out 5.518 HRD-out 59.23, 23.98 -59.97, 130.51 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 157.25, -27.9 APE9-dihe-na -72.13, -171.14 APE8-dihe-in -87.76, 105.63 APE8-rot-in 312.46 APE67-dihe-in -38.16, -47.94 -61.77, -30.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.4094 K124A,Q154N,A203S,R251K,T287A,T288A,E336D None None XRAY 2.7 0.249 0.28 A 268.0 247.0 14 26 12 14 [[133, 383]] 1.0 3coh Homo sapiens CAMK_AURKA_HUMAN CAMK 6.8e-79 270.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3COHB O14965 128 388 403.0 83H:2 Type1 Inactive None 999.0 999.0 None -152.27, 69.79 -84.21, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 10.8967 Saltbr-out 5.5574 HRD-out 57.18, 24.4 -60.63, 130.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 156.6, -25.86 APE9-dihe-na -73.98, -172.9 APE8-dihe-in -86.31, 108.51 APE8-rot-in 309.97 APE67-dihe-in -38.32, -45.55 -61.11, -32.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.4236 K124A,Q154N,A203S,R251K,T287A,T288A,E336D None None XRAY 2.7 0.249 0.28 B 268.0 247.0 14 26 12 14 [[133, 383]] 1.0 3coh Homo sapiens CAMK_AURKA_HUMAN CAMK 6.8e-79 270.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3QBNA O14965 126 388 403.0 E9Z:1 Type1 Inactive None 999.0 999.0 None -129.73, 92.91 -54.77, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 12.8923 Saltbr-out 9.6775 HRD-out -87.09, 152.8 -108.3, -67.47 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -136.83, -66.52 APE9-dihe-na -169.05, -176.59 APE8-dihe-in -73.14, 145.1 APE8-rot-in 328.56 APE67-dihe-in -69.55, -10.29 -123.67, 37.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.1803 V279C,C290S,C393S None None XRAY 3.5 0.257 0.334 A 281.0 250.0 13 26 13 13 [[133, 383]] 1.0 3qbn Homo sapiens CAMK_AURKA_HUMAN CAMK 7.6e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3W2CA O14965 128 388 403.0 N15:401 Type1.5_Back Inactive None 999.0 999.0 None -119.68, 158.18 72.13, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 13.333 Saltbr-out 13.2922 HRD-none 999.0, 999.0 999.0, 999.0 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -105.03 APE8-rot-out 176.61 APE67-dihe-in -28.13, -45.18 -62.37, -55.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.45 0.256 0.32 A 261.0 203.0 58 26 9 17 [[133, 383]] 1.0 3w2c Homo sapiens CAMK_AURKA_HUMAN CAMK 5.5e-80 274.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3W2CG O14965 128 388 403.0 N15:401 Type1.5_Back Inactive None 999.0 999.0 None -124.56, -177.92 59.84, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 12.9554 Saltbr-out 11.8849 HRD-none 999.0, 999.0 999.0, 999.0 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -79.06 APE8-rot-out 175.53 APE67-dihe-in -38.36, -27.94 -71.96, -40.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.45 0.256 0.32 G 261.0 202.0 59 26 9 17 [[133, 383]] 1.0 3w2c Homo sapiens CAMK_AURKA_HUMAN CAMK 5.5e-80 274.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 2C6EB O14965 127 388 403.0 HPM:61388 Type1.5_Front Inactive None 999.0 999.0 None -108.73, 147.84 100.58, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 12.3335 Saltbr-out 11.7069 HRD-in -74.71, -88.37 86.19, 28.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -90.56 APE8-dihe-out -69.38, -179.33 APE8-rot-out 55.29 APE67-dihe-in -54.24, -12.3 -58.45, -38.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.5658 None None None XRAY 2.1 0.2 0.27 B 283.0 246.0 16 26 10 16 [[133, 383]] 1.0 2c6e Homo sapiens CAMK_AURKA_HUMAN CAMK 1.7e-79 272.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_HUMAN 3MYGA O14965 126 388 403.0 EML:1 Type1 None DFGin 6.6394 15.8274 BLAminus -122.31, -179.48 56.93, 60.99 -81.36, 19.85 281.57, 75.82 -60.89, -48.59 in-in in 8.8952 Saltbr-in 2.9006 HRD-in -65.99, -46.93 66.41, -15.04 in-in-none SNCiin in-none ActLoopNT-in 2.9842 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 158.04 APE8-rot-in 313.0 APE67-dihe-in -30.25, -41.2 -89.45, -15.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.222 0.245 A 272.0 252.0 11 26 15 11 [[133, 383]] 1.0 3myg Homo sapiens CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
AURKA AURKA_MOUSE 3D14A P97477 117 379 395.0 AK1:60001 Type1.5_Front Inactive DFGin 6.8294 16.1153 BLAminus -139.07, 172.86 70.75, 85.85 -101.44, 25.77 290.86, 79.7 -66.74, -24.1 out-out out 10.9784 Saltbr-out 7.7774 HRD-in -71.22, -52.01 70.27, -4.3 out-in-out SNCoio in-out ActLoopNT-in 2.8937 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -30.43 APE9-dihe-na -158.18, -138.37 APE8-dihe-in -81.17, 171.47 APE8-rot-out 71.66 APE67-dihe-in -52.26, -34.35 -85.54, 0.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.7127 APE9-dist-out 10.8821 N164G,K218R,M280L None None XRAY 1.9 0.213 0.257 A 272.0 257.0 6 26 20 6 [[124, 374]] 1.0 3d14 Mus musculus CAMK_AURKA_MOUSE CAMK 4.9e-80 274.5 1.0 256.0 256.0 264 265 266 268 270 153 172 176 244 246 245 247.0 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
AURKA AURKA_MOUSE 3D15A P97477 117 379 395.0 AK2:60001 Type1.5_Front Inactive DFGin 7.3413 16.5475 BLAminus -133.09, 171.12 62.7, 82.59 -93.04, 24.05 278.36, 81.94 -66.36, -33.72 out-out out 11.2602 Saltbr-out 7.4147 HRD-in -74.96, -54.78 78.32, -11.59 out-in-out SNCoio in-out ActLoopNT-in 2.8707 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -154.13 APE8-dihe-in -61.43, 168.75 APE8-rot-out 172.07 APE67-dihe-in -47.97, -35.28 -92.1, -4.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6283 N164G,K218R,M280L None None XRAY 2.3 0.238 0.287 A 272.0 256.0 7 26 19 7 [[124, 374]] 1.0 3d15 Mus musculus CAMK_AURKA_MOUSE CAMK 4.9e-80 274.5 1.0 256.0 256.0 264 265 266 268 270 153 172 176 244 246 245 247.0 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
AURKA AURKA_MOUSE 3D2IA P97477 118 379 395.0 AK3:60001 Type1.5_Front Inactive DFGin 6.9299 16.1516 BLAminus -138.38, 171.61 68.82, 84.95 -100.0, 33.08 285.24, 81.68 -70.28, -40.3 out-out out 11.0409 Saltbr-out 7.9092 HRD-in -79.0, -48.65 68.62, -9.76 out-in-out SNCoio in-out ActLoopNT-in 3.1489 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -64.89 APE9-dihe-na -137.07, -130.76 APE8-dihe-in -91.86, 172.43 APE8-rot-out 65.59 APE67-dihe-in -40.2, -35.42 -84.93, -8.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.3363 APE9-dist-out 10.4162 N164G,K218R,M280L None None XRAY 2.9 0.245 0.298 A 272.0 255.0 7 26 19 7 [[124, 374]] 1.0 3d2i Mus musculus CAMK_AURKA_MOUSE CAMK 4.9e-80 274.5 1.0 256.0 256.0 264 265 266 268 270 153 172 176 244 246 245 247.0 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
AURKA AURKA_MOUSE 3D2KA P97477 119 379 395.0 AK4:60001 Type1.5_Front Inactive DFGin 7.1535 16.0992 BLAminus -121.9, 166.39 73.54, 78.63 -94.98, 32.39 279.69, 79.25 -71.49, -37.35 out-out out 10.9394 Saltbr-out 7.2749 HRD-in -71.67, -45.16 66.48, -9.73 out-in-out SNCoio in-out ActLoopNT-in 3.2389 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 163.82 APE8-rot-out 51.06 APE67-dihe-in -54.24, -21.42 -103.79, -17.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 N164G,K218R,M280L None None XRAY 2.5 0.223 0.273 A 272.0 245.0 16 26 15 11 [[124, 374]] 1.0 3d2k Mus musculus CAMK_AURKA_MOUSE CAMK 4.9e-80 274.5 1.0 256.0 256.0 264 265 266 268 270 153 172 176 244 246 245 247.0 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
AURKA AURKA_MOUSE 3DJ7A P97477 117 379 395.0 AK7:60001 Type1.5_Front Inactive DFGin 6.747 16.2637 BLAminus -136.71, 173.78 65.51, 86.14 -100.61, 22.92 284.54, 84.94 -64.18, -29.0 out-out out 11.1438 Saltbr-out 7.5015 HRD-in -76.06, -47.14 68.45, -12.93 out-in-out SNCoio in-out ActLoopNT-in 2.8447 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -39.63 APE9-dihe-na -153.17, -157.42 APE8-dihe-in -67.83, 166.09 APE8-rot-out 60.32 APE67-dihe-in -43.83, -37.54 -88.19, -6.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.6443 APE9-dist-out 10.4942 N164G,K218R,M280L None None XRAY 2.8 0.269 0.296 A 272.0 257.0 6 26 20 6 [[124, 374]] 1.0 3dj7 Mus musculus CAMK_AURKA_MOUSE CAMK 4.9e-80 274.5 1.0 256.0 256.0 264 265 266 268 270 153 172 176 244 246 245 247.0 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
AURKA AURKA_MOUSE 3DJ5A P97477 119 379 395.0 AK5:60001 Type1.5_Front Inactive DFGin 7.6284 14.0475 None -136.29, 19.35 -86.03, 63.82 -110.83, -25.4 302.03, 108.73 -69.83, 159.06 out-out out 12.978 Saltbr-out 9.961 HRD-out -131.01, 157.62 -122.24, -24.88 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -101.12, -1.39 APE9-dihe-na 118.23, -161.25 APE8-dihe-in -83.03, 126.77 APE8-rot-in 300.87 APE67-dihe-in -53.36, -22.0 -45.96, -54.49 APE12-dist-out 14.9045 APE11-dist-out 15.549 APE10-dist-out 15.4089 APE9-dist-out 17.2512 N164G,K218R,M280L None None XRAY 1.8 0.21 0.243 A 272.0 252.0 9 26 17 9 [[124, 374]] 1.0 3dj5 Mus musculus CAMK_AURKA_MOUSE CAMK 4.9e-80 274.5 1.0 256.0 256.0 264 265 266 268 270 153 172 176 244 246 245 247.0 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
AURKA AURKA_MOUSE 3DJ6A P97477 119 379 395.0 AK6:60001 Type1.5_Front Inactive DFGin 7.5112 14.321 None -137.4, 19.75 -87.35, 63.1 -109.74, -19.59 301.75, 109.1 -74.07, 159.87 out-out out 12.9421 Saltbr-out 9.941 HRD-out -131.2, 158.79 -119.8, -29.43 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -104.43, 1.85 APE9-dihe-na 118.27, -159.99 APE8-dihe-in -81.23, 128.14 APE8-rot-in 303.03 APE67-dihe-in -53.67, -23.26 -47.45, -53.56 APE12-dist-out 15.1307 APE11-dist-out 15.7144 APE10-dist-out 15.886 APE9-dist-out 17.3598 N164G,K218R,M280L None None XRAY 1.7 0.217 0.261 A 272.0 252.0 9 26 17 9 [[124, 374]] 1.0 3dj6 Mus musculus CAMK_AURKA_MOUSE CAMK 4.9e-80 274.5 1.0 256.0 256.0 264 265 266 268 270 153 172 176 244 246 245 247.0 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
AURKA AURKA_MOUSE 3DAJA P97477 118 379 395.0 FXG:60001 Type1 Inactive DFGinter 9.5599 7.4022 None -134.29, 76.42 -147.47, -168.09 -117.97, 39.39 298.8, 92.41 -105.61, 25.6 out-out out 12.1112 Saltbr-out 11.1441 HRD-out -117.62, 145.96 -85.7, -149.13 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.61 APE8-rot-in 314.8 APE67-dihe-in -53.82, -22.73 -58.61, -35.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 N164G,K218R,T278D,M280L None None XRAY 2.0 0.253 0.284 A 272.0 245.0 17 26 13 13 [[124, 374]] 1.0 3daj Mus musculus CAMK_AURKA_MOUSE CAMK 6e-80 274.2 1.0 256.0 256.0 264 265 266 268 270 153 172 176 244 246 245 247.0 302 290 285 284 283 282 281 280 279 202 Aurora kinase A

CAMK_AURKA (Aurora kinase A)

Total number of chains: 8
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 62.5% 3D14A
DFGin None 2 25.0% 3DJ6A
DFGinter None 1 12.5% 3DAJA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AURKA AURKA_MOUSE 3D14A P97477 117 379 395.0 AK1:60001 Type1.5_Front Inactive DFGin 6.8294 16.1153 BLAminus -139.07, 172.86 70.75, 85.85 -101.44, 25.77 290.86, 79.7 -66.74, -24.1 out-out out 10.9784 Saltbr-out 7.7774 HRD-in -71.22, -52.01 70.27, -4.3 out-in-out SNCoio in-out ActLoopNT-in 2.8937 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -30.43 APE9-dihe-na -158.18, -138.37 APE8-dihe-in -81.17, 171.47 APE8-rot-out 71.66 APE67-dihe-in -52.26, -34.35 -85.54, 0.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.7127 APE9-dist-out 10.8821 N164G,K218R,M280L None None XRAY 1.9 0.213 0.257 A 272.0 257.0 6 26 20 6 [[124, 374]] 1.0 3d14 Mus musculus CAMK_AURKA_MOUSE CAMK 4.9e-80 274.5 1.0 256.0 256.0 264 265 266 268 270 153 172 176 244 246 245 247.0 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
AURKA AURKA_MOUSE 3D15A P97477 117 379 395.0 AK2:60001 Type1.5_Front Inactive DFGin 7.3413 16.5475 BLAminus -133.09, 171.12 62.7, 82.59 -93.04, 24.05 278.36, 81.94 -66.36, -33.72 out-out out 11.2602 Saltbr-out 7.4147 HRD-in -74.96, -54.78 78.32, -11.59 out-in-out SNCoio in-out ActLoopNT-in 2.8707 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -154.13 APE8-dihe-in -61.43, 168.75 APE8-rot-out 172.07 APE67-dihe-in -47.97, -35.28 -92.1, -4.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6283 N164G,K218R,M280L None None XRAY 2.3 0.238 0.287 A 272.0 256.0 7 26 19 7 [[124, 374]] 1.0 3d15 Mus musculus CAMK_AURKA_MOUSE CAMK 4.9e-80 274.5 1.0 256.0 256.0 264 265 266 268 270 153 172 176 244 246 245 247.0 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
AURKA AURKA_MOUSE 3D2IA P97477 118 379 395.0 AK3:60001 Type1.5_Front Inactive DFGin 6.9299 16.1516 BLAminus -138.38, 171.61 68.82, 84.95 -100.0, 33.08 285.24, 81.68 -70.28, -40.3 out-out out 11.0409 Saltbr-out 7.9092 HRD-in -79.0, -48.65 68.62, -9.76 out-in-out SNCoio in-out ActLoopNT-in 3.1489 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -64.89 APE9-dihe-na -137.07, -130.76 APE8-dihe-in -91.86, 172.43 APE8-rot-out 65.59 APE67-dihe-in -40.2, -35.42 -84.93, -8.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.3363 APE9-dist-out 10.4162 N164G,K218R,M280L None None XRAY 2.9 0.245 0.298 A 272.0 255.0 7 26 19 7 [[124, 374]] 1.0 3d2i Mus musculus CAMK_AURKA_MOUSE CAMK 4.9e-80 274.5 1.0 256.0 256.0 264 265 266 268 270 153 172 176 244 246 245 247.0 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
AURKA AURKA_MOUSE 3D2KA P97477 119 379 395.0 AK4:60001 Type1.5_Front Inactive DFGin 7.1535 16.0992 BLAminus -121.9, 166.39 73.54, 78.63 -94.98, 32.39 279.69, 79.25 -71.49, -37.35 out-out out 10.9394 Saltbr-out 7.2749 HRD-in -71.67, -45.16 66.48, -9.73 out-in-out SNCoio in-out ActLoopNT-in 3.2389 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 163.82 APE8-rot-out 51.06 APE67-dihe-in -54.24, -21.42 -103.79, -17.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 N164G,K218R,M280L None None XRAY 2.5 0.223 0.273 A 272.0 245.0 16 26 15 11 [[124, 374]] 1.0 3d2k Mus musculus CAMK_AURKA_MOUSE CAMK 4.9e-80 274.5 1.0 256.0 256.0 264 265 266 268 270 153 172 176 244 246 245 247.0 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
AURKA AURKA_MOUSE 3DJ7A P97477 117 379 395.0 AK7:60001 Type1.5_Front Inactive DFGin 6.747 16.2637 BLAminus -136.71, 173.78 65.51, 86.14 -100.61, 22.92 284.54, 84.94 -64.18, -29.0 out-out out 11.1438 Saltbr-out 7.5015 HRD-in -76.06, -47.14 68.45, -12.93 out-in-out SNCoio in-out ActLoopNT-in 2.8447 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -39.63 APE9-dihe-na -153.17, -157.42 APE8-dihe-in -67.83, 166.09 APE8-rot-out 60.32 APE67-dihe-in -43.83, -37.54 -88.19, -6.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.6443 APE9-dist-out 10.4942 N164G,K218R,M280L None None XRAY 2.8 0.269 0.296 A 272.0 257.0 6 26 20 6 [[124, 374]] 1.0 3dj7 Mus musculus CAMK_AURKA_MOUSE CAMK 4.9e-80 274.5 1.0 256.0 256.0 264 265 266 268 270 153 172 176 244 246 245 247.0 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
AURKA AURKA_MOUSE 3DJ5A P97477 119 379 395.0 AK5:60001 Type1.5_Front Inactive DFGin 7.6284 14.0475 None -136.29, 19.35 -86.03, 63.82 -110.83, -25.4 302.03, 108.73 -69.83, 159.06 out-out out 12.978 Saltbr-out 9.961 HRD-out -131.01, 157.62 -122.24, -24.88 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -101.12, -1.39 APE9-dihe-na 118.23, -161.25 APE8-dihe-in -83.03, 126.77 APE8-rot-in 300.87 APE67-dihe-in -53.36, -22.0 -45.96, -54.49 APE12-dist-out 14.9045 APE11-dist-out 15.549 APE10-dist-out 15.4089 APE9-dist-out 17.2512 N164G,K218R,M280L None None XRAY 1.8 0.21 0.243 A 272.0 252.0 9 26 17 9 [[124, 374]] 1.0 3dj5 Mus musculus CAMK_AURKA_MOUSE CAMK 4.9e-80 274.5 1.0 256.0 256.0 264 265 266 268 270 153 172 176 244 246 245 247.0 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
AURKA AURKA_MOUSE 3DJ6A P97477 119 379 395.0 AK6:60001 Type1.5_Front Inactive DFGin 7.5112 14.321 None -137.4, 19.75 -87.35, 63.1 -109.74, -19.59 301.75, 109.1 -74.07, 159.87 out-out out 12.9421 Saltbr-out 9.941 HRD-out -131.2, 158.79 -119.8, -29.43 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -104.43, 1.85 APE9-dihe-na 118.27, -159.99 APE8-dihe-in -81.23, 128.14 APE8-rot-in 303.03 APE67-dihe-in -53.67, -23.26 -47.45, -53.56 APE12-dist-out 15.1307 APE11-dist-out 15.7144 APE10-dist-out 15.886 APE9-dist-out 17.3598 N164G,K218R,M280L None None XRAY 1.7 0.217 0.261 A 272.0 252.0 9 26 17 9 [[124, 374]] 1.0 3dj6 Mus musculus CAMK_AURKA_MOUSE CAMK 4.9e-80 274.5 1.0 256.0 256.0 264 265 266 268 270 153 172 176 244 246 245 247.0 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
AURKA AURKA_MOUSE 3DAJA P97477 118 379 395.0 FXG:60001 Type1 Inactive DFGinter 9.5599 7.4022 None -134.29, 76.42 -147.47, -168.09 -117.97, 39.39 298.8, 92.41 -105.61, 25.6 out-out out 12.1112 Saltbr-out 11.1441 HRD-out -117.62, 145.96 -85.7, -149.13 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.61 APE8-rot-in 314.8 APE67-dihe-in -53.82, -22.73 -58.61, -35.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 N164G,K218R,T278D,M280L None None XRAY 2.0 0.253 0.284 A 272.0 245.0 17 26 13 13 [[124, 374]] 1.0 3daj Mus musculus CAMK_AURKA_MOUSE CAMK 6e-80 274.2 1.0 256.0 256.0 264 265 266 268 270 153 172 176 244 246 245 247.0 302 290 285 284 283 282 281 280 279 202 Aurora kinase A