6D5Y

MAPK1 (Mitogen-activated protein kinase 1)
Group: CMGC
Uniprot: MK01_HUMAN
Organism: Homo sapiens
Domain boundary: 25 - 313
Resolu: 2.86

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLAminus in-out in-out No_ligand No_ligand 13 - 357 8
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain A
        22         32         42         52 
MVRGQVFDVG PRYTNLSYIG EGAYGMVCSA YDNVNKVRVA 
        62         72         82         92 
IKKISPFEHQ TYCQRTLREI KILLRFRHEN IIGINDIIRA 
       102        112        122        132 
PTIEQMKDVY IVQDLMETDL YKLLKTQHLS NDHICYFLYQ 
       142        152        162        172 
ILRGLKYIHS ANVLHRDLKP SNLLLNTTCD LKICDFDLAR 
       182        192        202        212 
VADpdhdhtg fLTEYVATRW YRAPEIMLNS KGYTKSIDIW 
       222        232        242        252 
SVGCILAEML SNRPIFPGKH YLDQLNHILG ILGSPSQEDL 
       262        272        282        292 
NCIINLKARN YLLSLPHKNK VPWNRLFPNA DSKALDLLDK 
       302        312        322        332 
MLTFNPHKRI EVEQALAHPY LEQYYDPSDE PIAEAPFKFD 
       342        352 
MELDDLPKEK LKELIFEETA RFQPGyrs
Lower-case residues are disordered in structure.
Mutations: G169D
Phosphorylation: None