Protein kinases in complex with 1N1 (Dasatinib)

Total number of genes: 11
Total number of chains: 23
Spatial Dihedral Chains Representative
DFGin BLAminus 6 4QMSA
DFGin BLAplus 1 3K54A
DFGin BLBminus 2 5I9YA
DFGin BLBplus 4 5H2UA
DFGinter BABtrans 4 3SXRA
DFGinter None 4 4XEYA
DFGout None 1 5BVWA
None None 1 3LFAA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 3LFAA 2.1 Inactive None None in-in none-out 1N1 Type1
OTHER PKMYT1 PMYT1_HUMAN Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 5VCVA 1.92 Active DFGin BLAminus in-in in-in 1N1 Type1
STE STK10 STK10_HUMAN Serine/threonine-protein kinase 10 5OWRA 2.3 None DFGin BLAminus out-out out-none 1N1 Type1
STE STK24 STK24_HUMAN Serine/threonine-protein kinase 24 4QMSA 1.883 Inactive DFGin BLAminus in-out in-in 1N1 Type1
TYR ABL1 ABL1_HUMAN Tyrosine-protein kinase ABL1 7N9GB 2.2 Active DFGin BLAminus in-in in-in STI 1N1 Allosteric Type1
TYR ABL1 ABL1_HUMAN Tyrosine-protein kinase ABL1 2GQGA 2.4 Active DFGin BLAminus in-in in-in 1N1 Type1
TYR ABL1 ABL1_HUMAN Tyrosine-protein kinase ABL1 2GQGB 2.4 Active DFGin BLAminus in-in in-in 1N1 Type1.5_Back
TYR ABL1 ABL1_HUMAN Tyrosine-protein kinase ABL1 4XEYB 2.891 Inactive DFGinter BABtrans in-out out-in 1N1 Type1
TYR ABL1 ABL1_HUMAN Tyrosine-protein kinase ABL1 7N9GA 2.2 Inactive DFGinter None in-out out-in STI 1N1 Allosteric Type1
TYR ABL1 ABL1_HUMAN Tyrosine-protein kinase ABL1 7N9GC 2.2 Inactive DFGinter None in-none out-in STI 1N1 Allosteric Type1
TYR ABL1 ABL1_HUMAN Tyrosine-protein kinase ABL1 4XEYA 2.891 Inactive DFGinter None in-out out-in 1N1 Type1
TYR BMX BMX_HUMAN Cytoplasmic tyrosine-protein kinase BMX 3SXRA 2.4 Inactive DFGinter BABtrans out-out in-in 1N1 Type1
TYR BMX BMX_HUMAN Cytoplasmic tyrosine-protein kinase BMX 3SXRB 2.4 Inactive DFGinter BABtrans out-out in-in 1N1 Type1
TYR BTK BTK_HUMAN Tyrosine-protein kinase BTK 3K54A 1.94 Inactive DFGin BLAplus in-out none-out 1N1 Type1
TYR BTK BTK_HUMAN Tyrosine-protein kinase BTK 3OCTA 1.95 Inactive DFGinter BABtrans in-out out-in 1N1 Type1
TYR DDR1 DDR1_HUMAN Epithelial discoidin domain-containing receptor 1 6BSDA 2.606 Inactive DFGinter None in-in out-in 1N1 Type1
TYR DDR1 DDR1_HUMAN Epithelial discoidin domain-containing receptor 1 5BVWA 1.94 Inactive DFGout None in-in none-in 1N1 Type1
TYR EPHA2 EPHA2_HUMAN Ephrin type-A receptor 2 5I9YA 1.228 Inactive DFGin BLBminus in-in out-none 1N1 Type1
TYR EPHB4 EPHB4_HUMAN Ephrin type-B receptor 4 6FNMA 1.157 Inactive DFGin BLBminus in-in out-in 1N1 Type1
TYR PTK6 PTK6_HUMAN Protein-tyrosine kinase 6 5H2UA 2.24 Inactive DFGin BLBplus out-out out-out 1N1 Type1
TYR PTK6 PTK6_HUMAN Protein-tyrosine kinase 6 5H2UB 2.24 Inactive DFGin BLBplus out-out out-out 1N1 Type1
TYR PTK6 PTK6_HUMAN Protein-tyrosine kinase 6 5H2UC 2.24 Inactive DFGin BLBplus out-out out-out 1N1 Type1
TYR PTK6 PTK6_HUMAN Protein-tyrosine kinase 6 5H2UD 2.24 Inactive DFGin BLBplus out-out out-out 1N1 Type1

Protein kinases in complex with 1N1

Total number of genes: 16
Total number of chains: 35
Spatial Dihedral Chains Representative
DFGin BLAminus 13 4QMSA
DFGin BLAplus 1 3K54A
DFGin BLBminus 2 5I9YA
DFGin BLBplus 4 5H2UA
DFGin None 1 2Y6OA
DFGinter BABtrans 6 3SXRA
DFGinter None 4 4XEYA
DFGout None 3 3OHTA
None None 1 3LFAA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Gallus gallus TYR SRC SRC_CHICK Proto-oncogene tyrosine-protein kinase Src 3QLGA 2.75 None DFGin BLAminus in-in none-out 1N1 Type1.5_Back
Gallus gallus TYR SRC SRC_CHICK Proto-oncogene tyrosine-protein kinase Src 3QLGB 2.75 Inactive DFGin BLAminus in-in in-out 1N1 Type1.5_Back
Gallus gallus TYR SRC SRC_CHICK Proto-oncogene tyrosine-protein kinase Src 3G5DA 2.2 Active DFGin BLAminus in-in in-in 1N1 Type1.5_Back
Gallus gallus TYR SRC SRC_CHICK Proto-oncogene tyrosine-protein kinase Src 3G5DB 2.2 Active DFGin BLAminus in-in in-in 1N1 Type1.5_Back
Homo sapiens CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 3LFAA 2.1 Inactive None None in-in none-out 1N1 Type1
Homo sapiens OTHER PKMYT1 PMYT1_HUMAN Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 5VCVA 1.92 Active DFGin BLAminus in-in in-in 1N1 Type1
Homo sapiens STE STK10 STK10_HUMAN Serine/threonine-protein kinase 10 5OWRA 2.3 None DFGin BLAminus out-out out-none 1N1 Type1
Homo sapiens STE STK24 STK24_HUMAN Serine/threonine-protein kinase 24 4QMSA 1.883 Inactive DFGin BLAminus in-out in-in 1N1 Type1
Homo sapiens TYR ABL1 ABL1_HUMAN Tyrosine-protein kinase ABL1 7N9GB 2.2 Active DFGin BLAminus in-in in-in STI 1N1 Allosteric Type1
Homo sapiens TYR ABL1 ABL1_HUMAN Tyrosine-protein kinase ABL1 2GQGA 2.4 Active DFGin BLAminus in-in in-in 1N1 Type1
Homo sapiens TYR ABL1 ABL1_HUMAN Tyrosine-protein kinase ABL1 2GQGB 2.4 Active DFGin BLAminus in-in in-in 1N1 Type1.5_Back
Homo sapiens TYR ABL1 ABL1_HUMAN Tyrosine-protein kinase ABL1 4XEYB 2.891 Inactive DFGinter BABtrans in-out out-in 1N1 Type1
Homo sapiens TYR ABL1 ABL1_HUMAN Tyrosine-protein kinase ABL1 7N9GA 2.2 Inactive DFGinter None in-out out-in STI 1N1 Allosteric Type1
Homo sapiens TYR ABL1 ABL1_HUMAN Tyrosine-protein kinase ABL1 7N9GC 2.2 Inactive DFGinter None in-none out-in STI 1N1 Allosteric Type1
Homo sapiens TYR ABL1 ABL1_HUMAN Tyrosine-protein kinase ABL1 4XEYA 2.891 Inactive DFGinter None in-out out-in 1N1 Type1
Homo sapiens TYR BMX BMX_HUMAN Cytoplasmic tyrosine-protein kinase BMX 3SXRA 2.4 Inactive DFGinter BABtrans out-out in-in 1N1 Type1
Homo sapiens TYR BMX BMX_HUMAN Cytoplasmic tyrosine-protein kinase BMX 3SXRB 2.4 Inactive DFGinter BABtrans out-out in-in 1N1 Type1
Homo sapiens TYR BTK BTK_HUMAN Tyrosine-protein kinase BTK 3K54A 1.94 Inactive DFGin BLAplus in-out none-out 1N1 Type1
Homo sapiens TYR BTK BTK_HUMAN Tyrosine-protein kinase BTK 3OCTA 1.95 Inactive DFGinter BABtrans in-out out-in 1N1 Type1
Homo sapiens TYR DDR1 DDR1_HUMAN Epithelial discoidin domain-containing receptor 1 6BSDA 2.606 Inactive DFGinter None in-in out-in 1N1 Type1
Homo sapiens TYR DDR1 DDR1_HUMAN Epithelial discoidin domain-containing receptor 1 5BVWA 1.94 Inactive DFGout None in-in none-in 1N1 Type1
Homo sapiens TYR EPHA2 EPHA2_HUMAN Ephrin type-A receptor 2 5I9YA 1.228 Inactive DFGin BLBminus in-in out-none 1N1 Type1
Homo sapiens TYR EPHB4 EPHB4_HUMAN Ephrin type-B receptor 4 6FNMA 1.157 Inactive DFGin BLBminus in-in out-in 1N1 Type1
Homo sapiens TYR PTK6 PTK6_HUMAN Protein-tyrosine kinase 6 5H2UA 2.24 Inactive DFGin BLBplus out-out out-out 1N1 Type1
Homo sapiens TYR PTK6 PTK6_HUMAN Protein-tyrosine kinase 6 5H2UB 2.24 Inactive DFGin BLBplus out-out out-out 1N1 Type1
Homo sapiens TYR PTK6 PTK6_HUMAN Protein-tyrosine kinase 6 5H2UC 2.24 Inactive DFGin BLBplus out-out out-out 1N1 Type1
Homo sapiens TYR PTK6 PTK6_HUMAN Protein-tyrosine kinase 6 5H2UD 2.24 Inactive DFGin BLBplus out-out out-out 1N1 Type1
Mus musculus TYR ABL2 ABL2_MOUSE Tyrosine-protein kinase ABL2 4XLIA 2.5 Inactive DFGin BLAminus in-out in-in 1N1 Type1.5_Back
Mus musculus TYR ABL2 ABL2_MOUSE Tyrosine-protein kinase ABL2 4XLIB 2.5 Active DFGin BLAminus in-in in-in 1N1 Type1.5_Back
Mus musculus TYR BTK BTK_MOUSE Tyrosine-protein kinase BTK 8S9FA 2.6 Inactive DFGinter BABtrans out-out out-none 1N1 Type1
Mus musculus TYR BTK BTK_MOUSE Tyrosine-protein kinase BTK 8S9FB 2.6 Inactive DFGinter BABtrans out-out out-out 1N1 Type1
Mus musculus TYR EPHA4 EPHA4_MOUSE Ephrin type-A receptor 4 2Y6OA 1.543 Inactive DFGin None in-in none-in 1N1 Type1
Mus musculus TYR LYN LYN_MOUSE Tyrosine-protein kinase Lyn 2ZVAA 2.6 Active DFGin BLAminus in-in in-in 1N1 Type1.5_Back
Salmo salar CMGC P38A A9UJZ9_SALSA mitogen-activated protein kinase 3OHTA 2.7 Inactive DFGout None in-in none-none 1N1 1N1 Type1.5_Back Allosteric
Salmo salar CMGC P38A A9UJZ9_SALSA mitogen-activated protein kinase 3OHTB 2.7 Inactive DFGout None in-in none-none 1N1 1N1 Type1.5_Back Allosteric

Protein kinases in complex with 1N1

Total number of genes: 6
Total number of chains: 12
Spatial Dihedral Chains Representative
DFGin BLAminus 7 4XLIA
DFGin None 1 2Y6OA
DFGinter BABtrans 2 8S9FB
DFGout None 2 3OHTA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Gallus gallus TYR SRC SRC_CHICK Proto-oncogene tyrosine-protein kinase Src 3QLGA 2.75 None DFGin BLAminus in-in none-out 1N1 Type1.5_Back
Gallus gallus TYR SRC SRC_CHICK Proto-oncogene tyrosine-protein kinase Src 3QLGB 2.75 Inactive DFGin BLAminus in-in in-out 1N1 Type1.5_Back
Gallus gallus TYR SRC SRC_CHICK Proto-oncogene tyrosine-protein kinase Src 3G5DA 2.2 Active DFGin BLAminus in-in in-in 1N1 Type1.5_Back
Gallus gallus TYR SRC SRC_CHICK Proto-oncogene tyrosine-protein kinase Src 3G5DB 2.2 Active DFGin BLAminus in-in in-in 1N1 Type1.5_Back
Mus musculus TYR ABL2 ABL2_MOUSE Tyrosine-protein kinase ABL2 4XLIA 2.5 Inactive DFGin BLAminus in-out in-in 1N1 Type1.5_Back
Mus musculus TYR ABL2 ABL2_MOUSE Tyrosine-protein kinase ABL2 4XLIB 2.5 Active DFGin BLAminus in-in in-in 1N1 Type1.5_Back
Mus musculus TYR BTK BTK_MOUSE Tyrosine-protein kinase BTK 8S9FA 2.6 Inactive DFGinter BABtrans out-out out-none 1N1 Type1
Mus musculus TYR BTK BTK_MOUSE Tyrosine-protein kinase BTK 8S9FB 2.6 Inactive DFGinter BABtrans out-out out-out 1N1 Type1
Mus musculus TYR EPHA4 EPHA4_MOUSE Ephrin type-A receptor 4 2Y6OA 1.543 Inactive DFGin None in-in none-in 1N1 Type1
Mus musculus TYR LYN LYN_MOUSE Tyrosine-protein kinase Lyn 2ZVAA 2.6 Active DFGin BLAminus in-in in-in 1N1 Type1.5_Back
Salmo salar CMGC P38A A9UJZ9_SALSA mitogen-activated protein kinase 3OHTA 2.7 Inactive DFGout None in-in none-none 1N1 1N1 Type1.5_Back Allosteric
Salmo salar CMGC P38A A9UJZ9_SALSA mitogen-activated protein kinase 3OHTB 2.7 Inactive DFGout None in-in none-none 1N1 1N1 Type1.5_Back Allosteric