STK10 (Serine/threonine-protein kinase 10)

Group: STE
Uniprot: STK10_HUMAN
Domain boundary: 36 - 294


Total number of chains: 26
Spatial Dihedral Chains Representative
DFGin BLAminus 8 AF-O94804-K1A
DFGin ABAminus 2 4USEA
DFGin BLBminus 1 7QGPA
DFGin None 2 5AJQA
DFGout BBAminus 3 6EIMB
DFGout None 8 4EQUB
None None 2 5OWQB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
4USEA 2.65 Inactive DFGin ABAminus in-out out-none R09 Type1 24 - 316 None None 7
4USEB 2.65 Inactive DFGin ABAminus in-out out-none R09 Type1 24 - 316 None None 6
AF-O94804-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 28 - 302 None None 0
4BC6A 2.2 None DFGin BLAminus in-out out-none XZN Type1 24 - 316 None None 8
2J7TA 2.0 None DFGin BLAminus in-none out-out 274 Type1 25 - 317 None None 4
5OWRA 2.3 None DFGin BLAminus out-out out-none 1N1 Type1 23 - 317 None None 7
6HXFA 2.09 Inactive DFGin BLAminus in-in out-out R70 Type1 24 - 313 None X185,X191,X208 3
6HXFB 2.09 Inactive DFGin BLAminus in-in out-out R70 Type1 24 - 314 None X185,X191,X208 0
6HXFC 2.09 Active DFGin BLAminus in-in in-in R70 Type1 24 - 312 None X185,X191,X208 0
6HXFD 2.09 Inactive DFGin BLAminus in-in out-out R70 Type1 23 - 312 None X185,X191,X208 0
7QGPA 1.9 Inactive DFGin BLBminus in-out out-out DJ8 Type1.5_Front 23 - 313 None None 0
5AJQA 2.2 Inactive DFGin None out-out out-out DB8 Type1 24 - 312 None None 6
5AJQB 2.2 Inactive DFGin None out-none out-none DB8 Type1 25 - 312 None None 13
6GTTA 2.25 Inactive DFGout BBAminus in-in none-none B96 Type2 18 - 316 None None 17
6EIMA 1.43 Inactive DFGout BBAminus in-in out-out B6E Type2 26 - 317 None None 0
6EIMB 1.43 Inactive DFGout BBAminus in-in out-out B6E Type2 23 - 317 None None 0
4AOTA 2.33 Inactive DFGout None out-out out-out GW8 Type1 18 - 314 None None 13
4AOTB 2.33 Inactive DFGout None out-out out-out GW8 Type1 18 - 314 None None 11
4USDA 3.05 Inactive DFGout None out-out none-out R09 Type1 24 - 314 None None 15
4USDB 3.05 Inactive DFGout None out-out none-out R09 Type1 24 - 314 None None 15
4EQUA 2.0 Inactive DFGout None in-in out-out G6I Type2 24 - 317 None None 9
4EQUB 2.0 Inactive DFGout None in-in out-out G6I Type2 24 - 317 None None 8
6I2YA 2.56 Inactive DFGout None out-out in-out 88Z Type2 24 - 317 None None 10
6I2YB 2.56 Inactive DFGout None out-none out-out 88Z Type2 24 - 317 None None 10
5OWQA 2.7 Inactive None None out-none none-none 38O Type1 30 - 317 None None 20
5OWQB 2.7 Inactive None None out-out none-none 38O Type1 32 - 317 None None 20

STK10 (Serine/threonine-protein kinase 10)

Group: STE
Total number of chains: 26
Spatial Dihedral Chains Representative
DFGin BLAminus 8 AF-O94804-K1A
DFGin ABAminus 2 4USEA
DFGin BLBminus 1 7QGPA
DFGin None 2 5AJQA
DFGout BBAminus 3 6EIMB
DFGout None 8 4EQUB
None None 2 5OWQB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens STK10_HUMAN 4USEA 2.65 Inactive DFGin ABAminus in-out out-none R09 Type1 24 - 316 None None 7
Homo sapiens STK10_HUMAN 4USEB 2.65 Inactive DFGin ABAminus in-out out-none R09 Type1 24 - 316 None None 6
Homo sapiens STK10_HUMAN AF-O94804-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 28 - 302 None None 0
Homo sapiens STK10_HUMAN 4BC6A 2.2 None DFGin BLAminus in-out out-none XZN Type1 24 - 316 None None 8
Homo sapiens STK10_HUMAN 2J7TA 2.0 None DFGin BLAminus in-none out-out 274 Type1 25 - 317 None None 4
Homo sapiens STK10_HUMAN 5OWRA 2.3 None DFGin BLAminus out-out out-none 1N1 Type1 23 - 317 None None 7
Homo sapiens STK10_HUMAN 6HXFA 2.09 Inactive DFGin BLAminus in-in out-out R70 Type1 24 - 313 None X185,X191,X208 3
Homo sapiens STK10_HUMAN 6HXFB 2.09 Inactive DFGin BLAminus in-in out-out R70 Type1 24 - 314 None X185,X191,X208 0
Homo sapiens STK10_HUMAN 6HXFC 2.09 Active DFGin BLAminus in-in in-in R70 Type1 24 - 312 None X185,X191,X208 0
Homo sapiens STK10_HUMAN 6HXFD 2.09 Inactive DFGin BLAminus in-in out-out R70 Type1 23 - 312 None X185,X191,X208 0
Homo sapiens STK10_HUMAN 7QGPA 1.9 Inactive DFGin BLBminus in-out out-out DJ8 Type1.5_Front 23 - 313 None None 0
Homo sapiens STK10_HUMAN 5AJQA 2.2 Inactive DFGin None out-out out-out DB8 Type1 24 - 312 None None 6
Homo sapiens STK10_HUMAN 5AJQB 2.2 Inactive DFGin None out-none out-none DB8 Type1 25 - 312 None None 13
Homo sapiens STK10_HUMAN 6GTTA 2.25 Inactive DFGout BBAminus in-in none-none B96 Type2 18 - 316 None None 17
Homo sapiens STK10_HUMAN 6EIMA 1.43 Inactive DFGout BBAminus in-in out-out B6E Type2 26 - 317 None None 0
Homo sapiens STK10_HUMAN 6EIMB 1.43 Inactive DFGout BBAminus in-in out-out B6E Type2 23 - 317 None None 0
Homo sapiens STK10_HUMAN 4AOTA 2.33 Inactive DFGout None out-out out-out GW8 Type1 18 - 314 None None 13
Homo sapiens STK10_HUMAN 4AOTB 2.33 Inactive DFGout None out-out out-out GW8 Type1 18 - 314 None None 11
Homo sapiens STK10_HUMAN 4USDA 3.05 Inactive DFGout None out-out none-out R09 Type1 24 - 314 None None 15
Homo sapiens STK10_HUMAN 4USDB 3.05 Inactive DFGout None out-out none-out R09 Type1 24 - 314 None None 15
Homo sapiens STK10_HUMAN 4EQUA 2.0 Inactive DFGout None in-in out-out G6I Type2 24 - 317 None None 9
Homo sapiens STK10_HUMAN 4EQUB 2.0 Inactive DFGout None in-in out-out G6I Type2 24 - 317 None None 8
Homo sapiens STK10_HUMAN 6I2YA 2.56 Inactive DFGout None out-out in-out 88Z Type2 24 - 317 None None 10
Homo sapiens STK10_HUMAN 6I2YB 2.56 Inactive DFGout None out-none out-out 88Z Type2 24 - 317 None None 10
Homo sapiens STK10_HUMAN 5OWQA 2.7 Inactive None None out-none none-none 38O Type1 30 - 317 None None 20
Homo sapiens STK10_HUMAN 5OWQB 2.7 Inactive None None out-out none-none 38O Type1 32 - 317 None None 20

STK10 (Serine/threonine-protein kinase 10)

No non-human structures known.