BTK (Tyrosine-protein kinase BTK)

Group: TYR
Uniprot: BTK_HUMAN
Domain boundary: 402 - 653


Total number of chains: 141
Spatial Dihedral Chains Representative
DFGin BLAminus 1 AF-Q06187-K1A
DFGin BLAplus 4 1K2PA
DFGin BLBplus 128 6DI1A
DFGin None 2 3PIYA
DFGinter BABtrans 4 7YC9A
DFGinter None 1 6NFIA
None None 1 3PJ3A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-Q06187-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 394 - 659 None None 0
1K2PA 2.1 Inactive DFGin BLAplus out-out in-out No_ligand No_ligand 397 - 654 None None 0
3K54A 1.94 Inactive DFGin BLAplus in-out none-out 1N1 Type1 392 - 658 Y551E None 17
3PIZA 2.21 Inactive DFGin BLAplus in-in none-out 03C Type1 391 - 659 None None 16
3PJ1A 2.0 Inactive DFGin BLAplus in-in none-out LHL LHL Type1 Allosteric 391 - 659 None None 16
1K2PB 2.1 Inactive DFGin BLBplus out-out in-in No_ligand No_ligand 397 - 654 None None 0
3P08A 2.3 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 394 - 658 None None 13
3P08B 2.3 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 395 - 658 None None 6
6W8IA 3.8 Inactive DFGin BLBplus out-none out-out No_ligand No_ligand 393 - 657 None None 11
6W8IB 3.8 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 395 - 657 None None 12
4NWMA 2.03 Inactive DFGin BLBplus out-none out-out 2P5 Type1 396 - 657 None None 0
4NWMB 2.03 Inactive DFGin BLBplus out-none out-out 2P5 Type1 396 - 657 None None 0
6AUBA 1.65 Inactive DFGin BLBplus out-out out-out BXM Type1 395 - 657 None None 0
6S90A 1.82 Inactive DFGin BLBplus out-out out-out L0Z Type1 395 - 656 None None 0
6S90B 1.82 Inactive DFGin BLBplus out-out out-out L0Z Type1 395 - 656 None None 0
5BPYA 2.31 Inactive DFGin BLBplus out-out out-out 4UQ Type1 396 - 657 None None 0
5BPYB 2.31 Inactive DFGin BLBplus out-none out-out 4UQ Type1 396 - 657 None None 11
5JRSA 1.97 Inactive DFGin BLBplus out-out out-out 6MV Type1 396 - 656 None None 0
5JRSB 1.97 Inactive DFGin BLBplus out-none out-out 6MV Type1 396 - 655 None None 11
5T18A 1.5 Inactive DFGin BLBplus out-out out-out 73T Type1 396 - 658 None None 0
7KXNA 1.34 Inactive DFGin BLBplus out-out out-out X9P Type1 394 - 659 None None 0
7KXOA 1.94 Inactive DFGin BLBplus out-out out-out X9S Type1 395 - 659 None None 0
7LTYA 1.69 Inactive DFGin BLBplus out-out out-out YD7 Type1 393 - 658 None None 11
7LTZA 1.53 Inactive DFGin BLBplus out-out out-out YDA Type1 394 - 658 None None 0
7KXLA 1.84 Inactive DFGin BLBplus out-out out-out X9J Type1 392 - 658 None None 0
5ZZ4A 2.9 Inactive DFGin BLBplus out-none out-out 9M3 Type1 395 - 655 None None 0
5ZZ4B 2.9 Inactive DFGin BLBplus out-out out-out 9M3 Type1 393 - 655 None None 0
5ZZ4C 2.9 Inactive DFGin BLBplus out-none out-out 9M3 Type1 394 - 655 None None 0
5ZZ4D 2.9 Inactive DFGin BLBplus out-none out-out 9M3 Type1 393 - 655 None None 0
5ZZ4E 2.9 Inactive DFGin BLBplus out-out out-out 9M3 Type1 394 - 655 None None 0
5ZZ4F 2.9 Inactive DFGin BLBplus out-none out-out 9M3 Type1 393 - 655 None None 0
6O8IA 1.42 Inactive DFGin BLBplus out-out out-out LTJ Type1 391 - 658 None None 0
7N4QA 1.5 Inactive DFGin BLBplus out-out out-out 0B9 Type1 392 - 658 None None 7
7N4RA 1.62 Inactive DFGin BLBplus out-out out-out 0BG Type1 393 - 658 None None 9
7N4SA 2.05 Inactive DFGin BLBplus out-out out-out 0B0 Type1 394 - 658 None None 8
4RX5A 1.356 Inactive DFGin BLBplus out-out out-out 3YO Type1 394 - 657 None None 0
5KUPA 1.389 Inactive DFGin BLBplus out-out out-out 6XL Type1 394 - 657 None None 0
5VGOA 1.621 Inactive DFGin BLBplus out-out out-out 9B1 Type1 394 - 657 None None 0
7KXQA 1.38 Inactive DFGin BLBplus out-out out-out X9Y Type1 390 - 659 None None 0
3OCSA 1.8 Inactive DFGin BLBplus out-none out-out 746 Type1 395 - 656 None None 0
4OTFA 1.95 Inactive DFGin BLBplus out-out out-out 2VL Type1 396 - 657 None None 0
4ZLYA 1.65 Inactive DFGin BLBplus out-out out-out 4RU Type1 389 - 658 None None 0
4ZLZA 2.0 Inactive DFGin BLBplus out-out out-out 4RV Type1 389 - 658 None None 0
8GC7A 1.9 Inactive DFGin BLBplus out-out out-out YXJ Type1 389 - 658 None None 0
8U2DA 1.95 Inactive DFGin BLBplus out-out out-out UQX Type1 389 - 658 None None 0
8U2EA 1.9 Inactive DFGin BLBplus out-out out-out UP9 Type1 389 - 658 None None 0
5U9DA 1.33 Inactive DFGin BLBplus out-out out-out 83P Type1 389 - 659 None None 0
5VFIA 1.59 Inactive DFGin BLBplus out-out out-out 9AJ Type1 389 - 659 None None 0
6DI0A 1.3 Inactive DFGin BLBplus out-out out-out GJG Type1 389 - 659 None None 0
6DI1A 1.1 Inactive DFGin BLBplus out-out out-out GJD Type1 389 - 659 None None 0
6DI9A 1.25 Inactive DFGin BLBplus out-none out-out GJJ Type1 392 - 659 None None 10
6NFHA 1.4 Inactive DFGin BLBplus out-out out-out KLM Type1 389 - 659 None None 0
7KXMA 1.33 Inactive DFGin BLBplus out-out out-out X9M Type1 389 - 659 None None 0
7KXPA 1.83 Inactive DFGin BLBplus out-out out-out X9V Type1 389 - 659 None None 0
3PIXA 1.85 Inactive DFGin BLBplus out-out out-out 027 Type1 391 - 658 None None 0
5J87A 1.59 Inactive DFGin BLBplus out-out out-out N42 Type1 396 - 658 None None 0
5J87B 1.59 Inactive DFGin BLBplus out-out out-out N42 Type1 385 - 658 None None 0
5J87C 1.59 Inactive DFGin BLBplus out-out out-out N42 Type1 396 - 656 None None 0
5J87D 1.59 Inactive DFGin BLBplus out-out out-out N42 Type1 396 - 658 None None 0
6TFPA 2.0 Inactive DFGin BLBplus out-out out-out N6Z Type1 393 - 658 None None 0
6TFPB 2.0 Inactive DFGin BLBplus out-out out-out N6Z Type1 385 - 658 None None 0
6TFPC 2.0 Inactive DFGin BLBplus out-none out-out N6Z Type1 394 - 657 None None 0
6TFPD 2.0 Inactive DFGin BLBplus out-none out-out N6Z Type1 392 - 657 None None 0
6TFPE 2.0 Inactive DFGin BLBplus out-none out-out N6Z Type1 394 - 657 None None 0
5P9FA 1.71 Inactive DFGin BLBplus out-out out-out 2VL Type1 394 - 659 None None 0
5P9GA 1.75 Inactive DFGin BLBplus out-out out-out 7G6 Type1 394 - 658 None None 0
5P9HA 1.95 Inactive DFGin BLBplus out-none out-out 7G7 Type1 395 - 658 None None 0
5P9KA 1.28 Inactive DFGin BLBplus out-out out-out 7G8 Type1 389 - 659 None None 0
5P9LA 1.25 Inactive DFGin BLBplus out-none out-out 7G9 Type1 392 - 657 None None 10
6AUAA 1.66 Inactive DFGin BLBplus out-out out-out BXJ Type1 394 - 656 None None 0
6NZMA 1.72 Inactive DFGin BLBplus out-none out-out L9S Type1 395 - 659 None None 0
6NZMD 1.72 Inactive DFGin BLBplus out-none out-out L9S Type1 395 - 659 None None 0
5BQ0A 1.57 Inactive DFGin BLBplus out-out out-out 4US Type1 389 - 659 None None 6
8FLHA 1.55 Inactive DFGin BLBplus out-out out-out Y8H Type1 392 - 658 None None 1
8FLVA 1.3 Inactive DFGin BLBplus out-out out-out ZB9 Type1 393 - 659 None None 0
4Z3VA 1.6 Inactive DFGin BLBplus out-out out-out 4L6 Type1 389 - 659 None None 0
7N5OA 1.25 Inactive DFGin BLBplus out-out out-out 0BQ Type1 389 - 658 None None 0
7N5RA 1.55 Inactive DFGin BLBplus out-out out-out 0UW Type1 389 - 658 None None 0
7N5XA 1.6 Inactive DFGin BLBplus out-out out-out 0GW Type1 389 - 658 None None 1
7N5YA 1.85 Inactive DFGin BLBplus out-out out-out 0CI Type1 389 - 658 None None 0
6BIKA 1.901 Inactive DFGin BLBplus out-none out-out DTJ Type1 395 - 657 None None 0
6BKEA 1.95 Inactive DFGin BLBplus out-none out-out DVJ Type1 395 - 657 None None 0
6BKHA 1.792 Inactive DFGin BLBplus out-none out-out DVD Type1 396 - 657 None None 0
6BLNA 1.3 Inactive DFGin BLBplus out-none out-out DY4 Type1 395 - 657 None None 0
6XE4A 1.6 Inactive DFGin BLBplus out-out out-out V1G Type1 395 - 657 None None 0
6VXQA 1.4 Inactive DFGin BLBplus out-out out-out RQS Type1 392 - 658 None None 9
6W06A 1.55 Inactive DFGin BLBplus out-out out-out S5M Type1 393 - 659 None None 0
6W07A 1.51 Inactive DFGin BLBplus out-out out-out S9A Type1 393 - 658 None None 0
8FLGA 2.2 Inactive DFGin BLBplus out-out out-out Y8C Type1 395 - 659 None None 0
4OT5A 1.55 Inactive DFGin BLBplus out-out out-out 481 Type1 396 - 658 M489A,R492A,E624A,K625A None 0
4OT6A 2.05 Inactive DFGin BLBplus out-out out-out 2V1 Type1 394 - 658 M489A,R492A,E624A,K625A None 0
4OTQA 1.55 Inactive DFGin BLBplus out-out out-out 2V2 Type1 396 - 658 M489A,R492A,E624A,K625A None 0
4OTRA 1.95 Inactive DFGin BLBplus out-out out-out 2V3 Type1 396 - 658 M489A,R492A,E624A,K625A None 0
4RFYA 1.7 Inactive DFGin BLBplus out-out out-out 3OU Type1 396 - 658 M489A,R492A,E624A,K625A None 0
4RFZA 1.17 Inactive DFGin BLBplus out-out out-out 3OV Type1 396 - 658 M489A,R492A,E624A,K625A None 0
4RG0A 2.5 Inactive DFGin BLBplus out-out out-out 3P0 Type1 396 - 658 M489A,R492A,E624A,K625A None 0
6EP9A 2.01 Inactive DFGin BLBplus out-out out-out BNB Type1 396 - 658 M489A,R492A,E624A,K625A None 0
6HRPA 1.12 Inactive DFGin BLBplus out-out out-out GMQ Type1 396 - 658 M489A,R492A,E624A,K625A None 0
6HRTA 1.36 Inactive DFGin BLBplus out-out out-out GMW Type1 396 - 658 M489A,R492A,E624A,K625A None 0
8GC8A 1.75 Inactive DFGin BLBplus out-none none-out YXJ Type1 392 - 658 L528W None 14
8EJBA 1.58 Inactive DFGin BLBplus out-out out-out WKC PD Type1 Allosteric 389 - 658 None None 0
6X3NA 1.95 Inactive DFGin BLBplus out-out none-in ULV 5WE Type1 Allosteric 392 - 659 None None 14
6BKWA 1.499 Inactive DFGin BLBplus out-out out-out DXM FPZ Type1 Type1 393 - 657 None None 0
6J6MA 1.25 Inactive DFGin BLBplus out-out out-out BA0 Type1.5_Back 393 - 659 None None 0
7R61A 1.52 Inactive DFGin BLBplus out-out out-out 2IJ Type1.5_Back 390 - 659 None None 2
6DI3A 2.0 Inactive DFGin BLBplus out-out out-out GJA Type1.5_Back 393 - 659 None None 9
6DI5A 1.42 Inactive DFGin BLBplus out-out out-out GJ7 Type1.5_Back 389 - 659 None None 0
6N9PA 2.23 Inactive DFGin BLBplus out-out out-out KHD Type1.5_Back 389 - 659 None None 0
6OMUA 1.41 Inactive DFGin BLBplus out-out out-out MZJ Type1.5_Back 389 - 659 None None 0
7L5OA 1.21 Inactive DFGin BLBplus out-out out-out R1L Type1.5_Back 389 - 658 None None 0
7L5PA 2.14 Inactive DFGin BLBplus out-out out-out R1L Type1.5_Back 392 - 659 None None 0
7L5PB 2.14 Inactive DFGin BLBplus out-out out-out R1L Type1.5_Back 393 - 658 None None 0
7R60A 1.94 Inactive DFGin BLBplus out-out out-out 2IE Type1.5_Back 389 - 659 None None 0
8E2MA 1.904 Inactive DFGin BLBplus out-out out-out UB6 Type1.5_Back 389 - 658 None None 0
6W7OA 2.17 Inactive DFGin BLBplus out-out out-out TL7 Type1.5_Back 396 - 656 None None 0
6W7OB 2.17 Inactive DFGin BLBplus out-out out-out TL7 Type1.5_Back 396 - 658 None None 0
6W8IC 3.8 Inactive DFGin BLBplus out-out out-out TKY Type1.5_Back 395 - 657 None None 0
8DSOB 2.334 Inactive DFGin BLBplus out-none out-out TOO Type1.5_Back 392 - 659 None None 8
4YHFA 2.2 Inactive DFGin BLBplus out-none out-out 4C9 Type1.5_Back 391 - 658 None None 0
4YHFB 2.2 Inactive DFGin BLBplus out-out out-out 4C9 Type1.5_Back 390 - 658 None None 0
5P9IA 1.11 Inactive DFGin BLBplus out-out out-out 1E8 Type1.5_Back 389 - 659 None None 0
5P9JA 1.08 Inactive DFGin BLBplus out-out out-out 8E8 Type1.5_Back 394 - 659 None None 3
5P9MA 1.41 Inactive DFGin BLBplus out-out out-out 7GB Type1.5_Back 389 - 659 None None 0
3GENA 1.6 Inactive DFGin BLBplus out-out out-out B43 Type1.5_Back 392 - 658 None None 0
6E4FA 1.15 Inactive DFGin BLBplus out-out out-out HRA Type1.5_Back 389 - 658 None None 0
5FBOA 1.894 Inactive DFGin BLBplus out-out none-out 5WH 5WE Type1.5_Back Allosteric 392 - 659 None None 13
8FLNA 1.334 Inactive DFGin BLBplus out-out out-out Y7W BTB Type1.5_Front Allosteric 395 - 657 None None 0
5FBNC 1.8 Inactive DFGin BLBplus out-out out-out 5WF 5WE Type1.5_Front Allosteric 395 - 658 None None 8
6X3OA 1.9 Inactive DFGin BLBplus out-out out-out ULY 5WE Type1.5_Front Allosteric 395 - 659 None None 0
6X3OB 1.9 Inactive DFGin BLBplus out-out out-out ULY 5WE Type1.5_Front Allosteric 393 - 659 None None 0
8FLLA 1.498 Inactive DFGin BLBplus out-none out-out Y7W BTB Type1.5_Front Allosteric 395 - 658 None None 0
5FBND 1.8 Inactive DFGin BLBplus out-out out-in 5WF 5WE 5WE 5WE Type1.5_Front Allosteric Allosteric Allosteric 394 - 658 None None 10
6X3PA 1.34 Inactive DFGin BLBplus out-out out-out UM4 UM4 BTB Type1.5_Front Allosteric Type1 394 - 659 None None 0
3PIYA 2.55 Inactive DFGin None out-out out-out 585 Type1 391 - 658 None None 0
3PJ2A 1.75 Inactive DFGin None out-out none-out 04K Type1.5_Back 391 - 659 None None 18
5XYZA 2.64 Inactive DFGinter BABtrans out-out out-in GYL Type1 394 - 656 None None 14
5XYZB 2.64 Inactive DFGinter BABtrans out-out out-in GYL Type1 394 - 656 None None 14
7YC9A 1.4 Inactive DFGinter BABtrans out-out out-in IS4 Type1 395 - 658 None None 0
3OCTA 1.95 Inactive DFGinter BABtrans in-out out-in 1N1 Type1 394 - 656 V555R None 14
6NFIA 2.41 Inactive DFGinter None out-out none-out KLP Type1 392 - 659 None None 16
3PJ3A 1.85 Inactive None None in-in none-out 04L Type1 391 - 659 None None 19

BTK (Tyrosine-protein kinase BTK)

Group: TYR
Total number of chains: 155
Spatial Dihedral Chains Representative
DFGin BLAminus 1 AF-Q06187-K1A
DFGin BLAplus 4 1K2PA
DFGin BLBplus 140 6DI1A
DFGin None 2 3PIYA
DFGinter BABtrans 6 7YC9A
DFGinter None 1 6NFIA
None None 1 3PJ3A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Bos taurus Q3ZC95_BOVIN 4Y95A 1.599 Inactive DFGin BLBplus out-out out-out 746 Type1 395 - 659 L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P None 0
Bos taurus Q3ZC95_BOVIN 4Y95D 1.599 Inactive DFGin BLBplus out-out out-out 746 Type1 395 - 659 L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P None 0
Bos taurus Q3ZC95_BOVIN 4Y93A 1.695 Inactive DFGin BLBplus out-out out-out 746 Type1 1 - 658 L542M,S543T,V555T,R562K,S564A,P565S,Y617P None 0
Bos taurus Q3ZC95_BOVIN 4Y95B 1.599 Inactive DFGin BLBplus out-out out-out 746 PE4 Type1 Allosteric 395 - 659 L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P None 0
Bos taurus Q3ZC95_BOVIN 4Y95C 1.599 Inactive DFGin BLBplus out-out out-out 746 PE4 Type1 Allosteric 395 - 659 L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P None 0
Homo sapiens BTK_HUMAN AF-Q06187-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 394 - 659 None None 0
Homo sapiens BTK_HUMAN 1K2PA 2.1 Inactive DFGin BLAplus out-out in-out No_ligand No_ligand 397 - 654 None None 0
Homo sapiens BTK_HUMAN 3K54A 1.94 Inactive DFGin BLAplus in-out none-out 1N1 Type1 392 - 658 Y551E None 17
Homo sapiens BTK_HUMAN 3PIZA 2.21 Inactive DFGin BLAplus in-in none-out 03C Type1 391 - 659 None None 16
Homo sapiens BTK_HUMAN 3PJ1A 2.0 Inactive DFGin BLAplus in-in none-out LHL LHL Type1 Allosteric 391 - 659 None None 16
Homo sapiens BTK_HUMAN 1K2PB 2.1 Inactive DFGin BLBplus out-out in-in No_ligand No_ligand 397 - 654 None None 0
Homo sapiens BTK_HUMAN 3P08A 2.3 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 394 - 658 None None 13
Homo sapiens BTK_HUMAN 3P08B 2.3 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 395 - 658 None None 6
Homo sapiens BTK_HUMAN 6W8IA 3.8 Inactive DFGin BLBplus out-none out-out No_ligand No_ligand 393 - 657 None None 11
Homo sapiens BTK_HUMAN 6W8IB 3.8 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 395 - 657 None None 12
Homo sapiens BTK_HUMAN 4NWMA 2.03 Inactive DFGin BLBplus out-none out-out 2P5 Type1 396 - 657 None None 0
Homo sapiens BTK_HUMAN 4NWMB 2.03 Inactive DFGin BLBplus out-none out-out 2P5 Type1 396 - 657 None None 0
Homo sapiens BTK_HUMAN 6AUBA 1.65 Inactive DFGin BLBplus out-out out-out BXM Type1 395 - 657 None None 0
Homo sapiens BTK_HUMAN 6S90A 1.82 Inactive DFGin BLBplus out-out out-out L0Z Type1 395 - 656 None None 0
Homo sapiens BTK_HUMAN 6S90B 1.82 Inactive DFGin BLBplus out-out out-out L0Z Type1 395 - 656 None None 0
Homo sapiens BTK_HUMAN 5BPYA 2.31 Inactive DFGin BLBplus out-out out-out 4UQ Type1 396 - 657 None None 0
Homo sapiens BTK_HUMAN 5BPYB 2.31 Inactive DFGin BLBplus out-none out-out 4UQ Type1 396 - 657 None None 11
Homo sapiens BTK_HUMAN 5JRSA 1.97 Inactive DFGin BLBplus out-out out-out 6MV Type1 396 - 656 None None 0
Homo sapiens BTK_HUMAN 5JRSB 1.97 Inactive DFGin BLBplus out-none out-out 6MV Type1 396 - 655 None None 11
Homo sapiens BTK_HUMAN 5T18A 1.5 Inactive DFGin BLBplus out-out out-out 73T Type1 396 - 658 None None 0
Homo sapiens BTK_HUMAN 7KXNA 1.34 Inactive DFGin BLBplus out-out out-out X9P Type1 394 - 659 None None 0
Homo sapiens BTK_HUMAN 7KXOA 1.94 Inactive DFGin BLBplus out-out out-out X9S Type1 395 - 659 None None 0
Homo sapiens BTK_HUMAN 7LTYA 1.69 Inactive DFGin BLBplus out-out out-out YD7 Type1 393 - 658 None None 11
Homo sapiens BTK_HUMAN 7LTZA 1.53 Inactive DFGin BLBplus out-out out-out YDA Type1 394 - 658 None None 0
Homo sapiens BTK_HUMAN 7KXLA 1.84 Inactive DFGin BLBplus out-out out-out X9J Type1 392 - 658 None None 0
Homo sapiens BTK_HUMAN 5ZZ4A 2.9 Inactive DFGin BLBplus out-none out-out 9M3 Type1 395 - 655 None None 0
Homo sapiens BTK_HUMAN 5ZZ4B 2.9 Inactive DFGin BLBplus out-out out-out 9M3 Type1 393 - 655 None None 0
Homo sapiens BTK_HUMAN 5ZZ4C 2.9 Inactive DFGin BLBplus out-none out-out 9M3 Type1 394 - 655 None None 0
Homo sapiens BTK_HUMAN 5ZZ4D 2.9 Inactive DFGin BLBplus out-none out-out 9M3 Type1 393 - 655 None None 0
Homo sapiens BTK_HUMAN 5ZZ4E 2.9 Inactive DFGin BLBplus out-out out-out 9M3 Type1 394 - 655 None None 0
Homo sapiens BTK_HUMAN 5ZZ4F 2.9 Inactive DFGin BLBplus out-none out-out 9M3 Type1 393 - 655 None None 0
Homo sapiens BTK_HUMAN 6O8IA 1.42 Inactive DFGin BLBplus out-out out-out LTJ Type1 391 - 658 None None 0
Homo sapiens BTK_HUMAN 7N4QA 1.5 Inactive DFGin BLBplus out-out out-out 0B9 Type1 392 - 658 None None 7
Homo sapiens BTK_HUMAN 7N4RA 1.62 Inactive DFGin BLBplus out-out out-out 0BG Type1 393 - 658 None None 9
Homo sapiens BTK_HUMAN 7N4SA 2.05 Inactive DFGin BLBplus out-out out-out 0B0 Type1 394 - 658 None None 8
Homo sapiens BTK_HUMAN 4RX5A 1.356 Inactive DFGin BLBplus out-out out-out 3YO Type1 394 - 657 None None 0
Homo sapiens BTK_HUMAN 5KUPA 1.389 Inactive DFGin BLBplus out-out out-out 6XL Type1 394 - 657 None None 0
Homo sapiens BTK_HUMAN 5VGOA 1.621 Inactive DFGin BLBplus out-out out-out 9B1 Type1 394 - 657 None None 0
Homo sapiens BTK_HUMAN 7KXQA 1.38 Inactive DFGin BLBplus out-out out-out X9Y Type1 390 - 659 None None 0
Homo sapiens BTK_HUMAN 3OCSA 1.8 Inactive DFGin BLBplus out-none out-out 746 Type1 395 - 656 None None 0
Homo sapiens BTK_HUMAN 4OTFA 1.95 Inactive DFGin BLBplus out-out out-out 2VL Type1 396 - 657 None None 0
Homo sapiens BTK_HUMAN 4ZLYA 1.65 Inactive DFGin BLBplus out-out out-out 4RU Type1 389 - 658 None None 0
Homo sapiens BTK_HUMAN 4ZLZA 2.0 Inactive DFGin BLBplus out-out out-out 4RV Type1 389 - 658 None None 0
Homo sapiens BTK_HUMAN 8GC7A 1.9 Inactive DFGin BLBplus out-out out-out YXJ Type1 389 - 658 None None 0
Homo sapiens BTK_HUMAN 8U2DA 1.95 Inactive DFGin BLBplus out-out out-out UQX Type1 389 - 658 None None 0
Homo sapiens BTK_HUMAN 8U2EA 1.9 Inactive DFGin BLBplus out-out out-out UP9 Type1 389 - 658 None None 0
Homo sapiens BTK_HUMAN 5U9DA 1.33 Inactive DFGin BLBplus out-out out-out 83P Type1 389 - 659 None None 0
Homo sapiens BTK_HUMAN 5VFIA 1.59 Inactive DFGin BLBplus out-out out-out 9AJ Type1 389 - 659 None None 0
Homo sapiens BTK_HUMAN 6DI0A 1.3 Inactive DFGin BLBplus out-out out-out GJG Type1 389 - 659 None None 0
Homo sapiens BTK_HUMAN 6DI1A 1.1 Inactive DFGin BLBplus out-out out-out GJD Type1 389 - 659 None None 0
Homo sapiens BTK_HUMAN 6DI9A 1.25 Inactive DFGin BLBplus out-none out-out GJJ Type1 392 - 659 None None 10
Homo sapiens BTK_HUMAN 6NFHA 1.4 Inactive DFGin BLBplus out-out out-out KLM Type1 389 - 659 None None 0
Homo sapiens BTK_HUMAN 7KXMA 1.33 Inactive DFGin BLBplus out-out out-out X9M Type1 389 - 659 None None 0
Homo sapiens BTK_HUMAN 7KXPA 1.83 Inactive DFGin BLBplus out-out out-out X9V Type1 389 - 659 None None 0
Homo sapiens BTK_HUMAN 3PIXA 1.85 Inactive DFGin BLBplus out-out out-out 027 Type1 391 - 658 None None 0
Homo sapiens BTK_HUMAN 5J87A 1.59 Inactive DFGin BLBplus out-out out-out N42 Type1 396 - 658 None None 0
Homo sapiens BTK_HUMAN 5J87B 1.59 Inactive DFGin BLBplus out-out out-out N42 Type1 385 - 658 None None 0
Homo sapiens BTK_HUMAN 5J87C 1.59 Inactive DFGin BLBplus out-out out-out N42 Type1 396 - 656 None None 0
Homo sapiens BTK_HUMAN 5J87D 1.59 Inactive DFGin BLBplus out-out out-out N42 Type1 396 - 658 None None 0
Homo sapiens BTK_HUMAN 6TFPA 2.0 Inactive DFGin BLBplus out-out out-out N6Z Type1 393 - 658 None None 0
Homo sapiens BTK_HUMAN 6TFPB 2.0 Inactive DFGin BLBplus out-out out-out N6Z Type1 385 - 658 None None 0
Homo sapiens BTK_HUMAN 6TFPC 2.0 Inactive DFGin BLBplus out-none out-out N6Z Type1 394 - 657 None None 0
Homo sapiens BTK_HUMAN 6TFPD 2.0 Inactive DFGin BLBplus out-none out-out N6Z Type1 392 - 657 None None 0
Homo sapiens BTK_HUMAN 6TFPE 2.0 Inactive DFGin BLBplus out-none out-out N6Z Type1 394 - 657 None None 0
Homo sapiens BTK_HUMAN 5P9FA 1.71 Inactive DFGin BLBplus out-out out-out 2VL Type1 394 - 659 None None 0
Homo sapiens BTK_HUMAN 5P9GA 1.75 Inactive DFGin BLBplus out-out out-out 7G6 Type1 394 - 658 None None 0
Homo sapiens BTK_HUMAN 5P9HA 1.95 Inactive DFGin BLBplus out-none out-out 7G7 Type1 395 - 658 None None 0
Homo sapiens BTK_HUMAN 5P9KA 1.28 Inactive DFGin BLBplus out-out out-out 7G8 Type1 389 - 659 None None 0
Homo sapiens BTK_HUMAN 5P9LA 1.25 Inactive DFGin BLBplus out-none out-out 7G9 Type1 392 - 657 None None 10
Homo sapiens BTK_HUMAN 6AUAA 1.66 Inactive DFGin BLBplus out-out out-out BXJ Type1 394 - 656 None None 0
Homo sapiens BTK_HUMAN 6NZMA 1.72 Inactive DFGin BLBplus out-none out-out L9S Type1 395 - 659 None None 0
Homo sapiens BTK_HUMAN 6NZMD 1.72 Inactive DFGin BLBplus out-none out-out L9S Type1 395 - 659 None None 0
Homo sapiens BTK_HUMAN 5BQ0A 1.57 Inactive DFGin BLBplus out-out out-out 4US Type1 389 - 659 None None 6
Homo sapiens BTK_HUMAN 8FLHA 1.55 Inactive DFGin BLBplus out-out out-out Y8H Type1 392 - 658 None None 1
Homo sapiens BTK_HUMAN 8FLVA 1.3 Inactive DFGin BLBplus out-out out-out ZB9 Type1 393 - 659 None None 0
Homo sapiens BTK_HUMAN 4Z3VA 1.6 Inactive DFGin BLBplus out-out out-out 4L6 Type1 389 - 659 None None 0
Homo sapiens BTK_HUMAN 7N5OA 1.25 Inactive DFGin BLBplus out-out out-out 0BQ Type1 389 - 658 None None 0
Homo sapiens BTK_HUMAN 7N5RA 1.55 Inactive DFGin BLBplus out-out out-out 0UW Type1 389 - 658 None None 0
Homo sapiens BTK_HUMAN 7N5XA 1.6 Inactive DFGin BLBplus out-out out-out 0GW Type1 389 - 658 None None 1
Homo sapiens BTK_HUMAN 7N5YA 1.85 Inactive DFGin BLBplus out-out out-out 0CI Type1 389 - 658 None None 0
Homo sapiens BTK_HUMAN 6BIKA 1.901 Inactive DFGin BLBplus out-none out-out DTJ Type1 395 - 657 None None 0
Homo sapiens BTK_HUMAN 6BKEA 1.95 Inactive DFGin BLBplus out-none out-out DVJ Type1 395 - 657 None None 0
Homo sapiens BTK_HUMAN 6BKHA 1.792 Inactive DFGin BLBplus out-none out-out DVD Type1 396 - 657 None None 0
Homo sapiens BTK_HUMAN 6BLNA 1.3 Inactive DFGin BLBplus out-none out-out DY4 Type1 395 - 657 None None 0
Homo sapiens BTK_HUMAN 6XE4A 1.6 Inactive DFGin BLBplus out-out out-out V1G Type1 395 - 657 None None 0
Homo sapiens BTK_HUMAN 6VXQA 1.4 Inactive DFGin BLBplus out-out out-out RQS Type1 392 - 658 None None 9
Homo sapiens BTK_HUMAN 6W06A 1.55 Inactive DFGin BLBplus out-out out-out S5M Type1 393 - 659 None None 0
Homo sapiens BTK_HUMAN 6W07A 1.51 Inactive DFGin BLBplus out-out out-out S9A Type1 393 - 658 None None 0
Homo sapiens BTK_HUMAN 8FLGA 2.2 Inactive DFGin BLBplus out-out out-out Y8C Type1 395 - 659 None None 0
Homo sapiens BTK_HUMAN 4OT5A 1.55 Inactive DFGin BLBplus out-out out-out 481 Type1 396 - 658 M489A,R492A,E624A,K625A None 0
Homo sapiens BTK_HUMAN 4OT6A 2.05 Inactive DFGin BLBplus out-out out-out 2V1 Type1 394 - 658 M489A,R492A,E624A,K625A None 0
Homo sapiens BTK_HUMAN 4OTQA 1.55 Inactive DFGin BLBplus out-out out-out 2V2 Type1 396 - 658 M489A,R492A,E624A,K625A None 0
Homo sapiens BTK_HUMAN 4OTRA 1.95 Inactive DFGin BLBplus out-out out-out 2V3 Type1 396 - 658 M489A,R492A,E624A,K625A None 0
Homo sapiens BTK_HUMAN 4RFYA 1.7 Inactive DFGin BLBplus out-out out-out 3OU Type1 396 - 658 M489A,R492A,E624A,K625A None 0
Homo sapiens BTK_HUMAN 4RFZA 1.17 Inactive DFGin BLBplus out-out out-out 3OV Type1 396 - 658 M489A,R492A,E624A,K625A None 0
Homo sapiens BTK_HUMAN 4RG0A 2.5 Inactive DFGin BLBplus out-out out-out 3P0 Type1 396 - 658 M489A,R492A,E624A,K625A None 0
Homo sapiens BTK_HUMAN 6EP9A 2.01 Inactive DFGin BLBplus out-out out-out BNB Type1 396 - 658 M489A,R492A,E624A,K625A None 0
Homo sapiens BTK_HUMAN 6HRPA 1.12 Inactive DFGin BLBplus out-out out-out GMQ Type1 396 - 658 M489A,R492A,E624A,K625A None 0
Homo sapiens BTK_HUMAN 6HRTA 1.36 Inactive DFGin BLBplus out-out out-out GMW Type1 396 - 658 M489A,R492A,E624A,K625A None 0
Homo sapiens BTK_HUMAN 8GC8A 1.75 Inactive DFGin BLBplus out-none none-out YXJ Type1 392 - 658 L528W None 14
Homo sapiens BTK_HUMAN 8EJBA 1.58 Inactive DFGin BLBplus out-out out-out WKC PD Type1 Allosteric 389 - 658 None None 0
Homo sapiens BTK_HUMAN 6X3NA 1.95 Inactive DFGin BLBplus out-out none-in ULV 5WE Type1 Allosteric 392 - 659 None None 14
Homo sapiens BTK_HUMAN 6BKWA 1.499 Inactive DFGin BLBplus out-out out-out DXM FPZ Type1 Type1 393 - 657 None None 0
Homo sapiens BTK_HUMAN 6J6MA 1.25 Inactive DFGin BLBplus out-out out-out BA0 Type1.5_Back 393 - 659 None None 0
Homo sapiens BTK_HUMAN 7R61A 1.52 Inactive DFGin BLBplus out-out out-out 2IJ Type1.5_Back 390 - 659 None None 2
Homo sapiens BTK_HUMAN 6DI3A 2.0 Inactive DFGin BLBplus out-out out-out GJA Type1.5_Back 393 - 659 None None 9
Homo sapiens BTK_HUMAN 6DI5A 1.42 Inactive DFGin BLBplus out-out out-out GJ7 Type1.5_Back 389 - 659 None None 0
Homo sapiens BTK_HUMAN 6N9PA 2.23 Inactive DFGin BLBplus out-out out-out KHD Type1.5_Back 389 - 659 None None 0
Homo sapiens BTK_HUMAN 6OMUA 1.41 Inactive DFGin BLBplus out-out out-out MZJ Type1.5_Back 389 - 659 None None 0
Homo sapiens BTK_HUMAN 7L5OA 1.21 Inactive DFGin BLBplus out-out out-out R1L Type1.5_Back 389 - 658 None None 0
Homo sapiens BTK_HUMAN 7L5PA 2.14 Inactive DFGin BLBplus out-out out-out R1L Type1.5_Back 392 - 659 None None 0
Homo sapiens BTK_HUMAN 7L5PB 2.14 Inactive DFGin BLBplus out-out out-out R1L Type1.5_Back 393 - 658 None None 0
Homo sapiens BTK_HUMAN 7R60A 1.94 Inactive DFGin BLBplus out-out out-out 2IE Type1.5_Back 389 - 659 None None 0
Homo sapiens BTK_HUMAN 8E2MA 1.904 Inactive DFGin BLBplus out-out out-out UB6 Type1.5_Back 389 - 658 None None 0
Homo sapiens BTK_HUMAN 6W7OA 2.17 Inactive DFGin BLBplus out-out out-out TL7 Type1.5_Back 396 - 656 None None 0
Homo sapiens BTK_HUMAN 6W7OB 2.17 Inactive DFGin BLBplus out-out out-out TL7 Type1.5_Back 396 - 658 None None 0
Homo sapiens BTK_HUMAN 6W8IC 3.8 Inactive DFGin BLBplus out-out out-out TKY Type1.5_Back 395 - 657 None None 0
Homo sapiens BTK_HUMAN 8DSOB 2.334 Inactive DFGin BLBplus out-none out-out TOO Type1.5_Back 392 - 659 None None 8
Homo sapiens BTK_HUMAN 4YHFA 2.2 Inactive DFGin BLBplus out-none out-out 4C9 Type1.5_Back 391 - 658 None None 0
Homo sapiens BTK_HUMAN 4YHFB 2.2 Inactive DFGin BLBplus out-out out-out 4C9 Type1.5_Back 390 - 658 None None 0
Homo sapiens BTK_HUMAN 5P9IA 1.11 Inactive DFGin BLBplus out-out out-out 1E8 Type1.5_Back 389 - 659 None None 0
Homo sapiens BTK_HUMAN 5P9JA 1.08 Inactive DFGin BLBplus out-out out-out 8E8 Type1.5_Back 394 - 659 None None 3
Homo sapiens BTK_HUMAN 5P9MA 1.41 Inactive DFGin BLBplus out-out out-out 7GB Type1.5_Back 389 - 659 None None 0
Homo sapiens BTK_HUMAN 3GENA 1.6 Inactive DFGin BLBplus out-out out-out B43 Type1.5_Back 392 - 658 None None 0
Homo sapiens BTK_HUMAN 6E4FA 1.15 Inactive DFGin BLBplus out-out out-out HRA Type1.5_Back 389 - 658 None None 0
Homo sapiens BTK_HUMAN 5FBOA 1.894 Inactive DFGin BLBplus out-out none-out 5WH 5WE Type1.5_Back Allosteric 392 - 659 None None 13
Homo sapiens BTK_HUMAN 8FLNA 1.334 Inactive DFGin BLBplus out-out out-out Y7W BTB Type1.5_Front Allosteric 395 - 657 None None 0
Homo sapiens BTK_HUMAN 5FBNC 1.8 Inactive DFGin BLBplus out-out out-out 5WF 5WE Type1.5_Front Allosteric 395 - 658 None None 8
Homo sapiens BTK_HUMAN 6X3OA 1.9 Inactive DFGin BLBplus out-out out-out ULY 5WE Type1.5_Front Allosteric 395 - 659 None None 0
Homo sapiens BTK_HUMAN 6X3OB 1.9 Inactive DFGin BLBplus out-out out-out ULY 5WE Type1.5_Front Allosteric 393 - 659 None None 0
Homo sapiens BTK_HUMAN 8FLLA 1.498 Inactive DFGin BLBplus out-none out-out Y7W BTB Type1.5_Front Allosteric 395 - 658 None None 0
Homo sapiens BTK_HUMAN 5FBND 1.8 Inactive DFGin BLBplus out-out out-in 5WF 5WE 5WE 5WE Type1.5_Front Allosteric Allosteric Allosteric 394 - 658 None None 10
Homo sapiens BTK_HUMAN 6X3PA 1.34 Inactive DFGin BLBplus out-out out-out UM4 UM4 BTB Type1.5_Front Allosteric Type1 394 - 659 None None 0
Homo sapiens BTK_HUMAN 3PIYA 2.55 Inactive DFGin None out-out out-out 585 Type1 391 - 658 None None 0
Homo sapiens BTK_HUMAN 3PJ2A 1.75 Inactive DFGin None out-out none-out 04K Type1.5_Back 391 - 659 None None 18
Homo sapiens BTK_HUMAN 5XYZA 2.64 Inactive DFGinter BABtrans out-out out-in GYL Type1 394 - 656 None None 14
Homo sapiens BTK_HUMAN 5XYZB 2.64 Inactive DFGinter BABtrans out-out out-in GYL Type1 394 - 656 None None 14
Homo sapiens BTK_HUMAN 7YC9A 1.4 Inactive DFGinter BABtrans out-out out-in IS4 Type1 395 - 658 None None 0
Homo sapiens BTK_HUMAN 3OCTA 1.95 Inactive DFGinter BABtrans in-out out-in 1N1 Type1 394 - 656 V555R None 14
Homo sapiens BTK_HUMAN 6NFIA 2.41 Inactive DFGinter None out-out none-out KLP Type1 392 - 659 None None 16
Homo sapiens BTK_HUMAN 3PJ3A 1.85 Inactive None None in-in none-out 04L Type1 391 - 659 None None 19
Mus musculus BTK_MOUSE 6MNYB 2.8 Inactive DFGin BLBplus out-out out-in No_ligand No_ligand 395 - 656 None None 9
Mus musculus BTK_MOUSE 4XI2A 2.6 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 214 - 657 None None 0
Mus musculus BTK_MOUSE 8S93A 2.1 Inactive DFGin BLBplus out-none out-out 9AJ Type1 1 - 659 Q91A,I92A,I94A,I95A,K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None 0
Mus musculus BTK_MOUSE 8GMBA 3.4 Inactive DFGin BLBplus out-none out-out 9AJ Type1 214 - 659 E298A,K300A,E301A,A384P,S386P,T387P,A388P,L390F,K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None 0
Mus musculus BTK_MOUSE 6MNYA 2.8 Inactive DFGin BLBplus out-out out-out JVP Type1.5_Back 395 - 656 None None 10
Mus musculus BTK_MOUSE 8FD9A 1.7 Inactive DFGin BLBplus out-none out-out XQQ Type1.5_Back 396 - 659 K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None 0
Mus musculus BTK_MOUSE 8FF0A 2.6 Inactive DFGin BLBplus out-none out-out 7GB Type1.5_Back 396 - 659 K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None 0
Mus musculus BTK_MOUSE 8S9FA 2.6 Inactive DFGinter BABtrans out-out out-none 1N1 Type1 392 - 659 L390G,Y551E,Y617P None 14
Mus musculus BTK_MOUSE 8S9FB 2.6 Inactive DFGinter BABtrans out-out out-out 1N1 Type1 392 - 659 L390G,Y551E,Y617P None 12

BTK (Tyrosine-protein kinase BTK)

Group: TYR
Total number of chains: 14
Spatial Dihedral Chains Representative
DFGin BLBplus 12 4Y95A
DFGinter BABtrans 2 8S9FB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Bos taurus Q3ZC95_BOVIN 4Y95A 1.599 Inactive DFGin BLBplus out-out out-out 746 Type1 395 - 659 L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P None 0
Bos taurus Q3ZC95_BOVIN 4Y95D 1.599 Inactive DFGin BLBplus out-out out-out 746 Type1 395 - 659 L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P None 0
Bos taurus Q3ZC95_BOVIN 4Y93A 1.695 Inactive DFGin BLBplus out-out out-out 746 Type1 1 - 658 L542M,S543T,V555T,R562K,S564A,P565S,Y617P None 0
Bos taurus Q3ZC95_BOVIN 4Y95B 1.599 Inactive DFGin BLBplus out-out out-out 746 PE4 Type1 Allosteric 395 - 659 L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P None 0
Bos taurus Q3ZC95_BOVIN 4Y95C 1.599 Inactive DFGin BLBplus out-out out-out 746 PE4 Type1 Allosteric 395 - 659 L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P None 0
Mus musculus BTK_MOUSE 6MNYB 2.8 Inactive DFGin BLBplus out-out out-in No_ligand No_ligand 395 - 656 None None 9
Mus musculus BTK_MOUSE 4XI2A 2.6 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 214 - 657 None None 0
Mus musculus BTK_MOUSE 8S93A 2.1 Inactive DFGin BLBplus out-none out-out 9AJ Type1 1 - 659 Q91A,I92A,I94A,I95A,K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None 0
Mus musculus BTK_MOUSE 8GMBA 3.4 Inactive DFGin BLBplus out-none out-out 9AJ Type1 214 - 659 E298A,K300A,E301A,A384P,S386P,T387P,A388P,L390F,K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None 0
Mus musculus BTK_MOUSE 6MNYA 2.8 Inactive DFGin BLBplus out-out out-out JVP Type1.5_Back 395 - 656 None None 10
Mus musculus BTK_MOUSE 8FD9A 1.7 Inactive DFGin BLBplus out-none out-out XQQ Type1.5_Back 396 - 659 K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None 0
Mus musculus BTK_MOUSE 8FF0A 2.6 Inactive DFGin BLBplus out-none out-out 7GB Type1.5_Back 396 - 659 K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None 0
Mus musculus BTK_MOUSE 8S9FA 2.6 Inactive DFGinter BABtrans out-out out-none 1N1 Type1 392 - 659 L390G,Y551E,Y617P None 14
Mus musculus BTK_MOUSE 8S9FB 2.6 Inactive DFGinter BABtrans out-out out-out 1N1 Type1 392 - 659 L390G,Y551E,Y617P None 12