ABL1 (Tyrosine-protein kinase ABL1)

Group: TYR
Uniprot: ABL1_HUMAN
Domain boundary: 242 - 495


Total number of chains: 87
Spatial Dihedral Chains Representative
DFGin BLAminus 15 AF-P00519-K1A
DFGin BLBplus 6 2G1TA
DFGinter BABtrans 3 7W7XA
DFGinter None 20 2G2HA
DFGout BBAminus 29 3QRJB
DFGout None 13 2HZIA
None None 1 4WA9A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
2HZ4A 2.8 Inactive DFGin BLAminus in-out in-in 4ST Allosteric 234 - 500 None None 0
2HZ4C 2.8 Active DFGin BLAminus in-in in-in 4ST Allosteric 234 - 500 None None 0
7N9GB 2.2 Active DFGin BLAminus in-in in-in STI 1N1 Allosteric Type1 233 - 498 None None 0
AF-P00519-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 234 - 503 None None 0
6XR6A 999.0 Inactive DFGin BLAminus in-in out-in No_ligand No_ligand 229 - 515 None None 0
4TWPA 2.4 Active DFGin BLAminus in-in in-in AXI Type1 233 - 503 T315I None 0
4TWPB 2.4 Active DFGin BLAminus in-in in-in AXI Type1 233 - 503 T315I None 0
2V7AA 2.5 Active DFGin BLAminus in-in in-in 627 Type1 233 - 503 T315I X393 0
2V7AB 2.5 Active DFGin BLAminus in-in in-in 627 Type1 234 - 503 T315I X393 0
2HZ4B 2.8 Active DFGin BLAminus in-in in-in 4ST Type1 233 - 498 None None 0
2GQGA 2.4 Active DFGin BLAminus in-in in-in 1N1 Type1 229 - 500 None X393 0
2F4JA 1.91 Active DFGin BLAminus in-in in-in VX6 Type1 227 - 513 H396P None 0
2G2IA 3.12 Active DFGin BLAminus in-in in-in ADP Type1 229 - 502 H396P None 0
2G2IB 3.12 Active DFGin BLAminus in-in in-in ADP Type1 232 - 500 H396P None 0
2GQGB 2.4 Active DFGin BLAminus in-in in-in 1N1 Type1.5_Back 229 - 499 None X393 0
8SSNB 2.86 Inactive DFGin BLBplus out-out none-none AY7 SKI Allosteric Type1 64 - 506 None None 18
8SSNA 2.86 Inactive DFGin BLBplus out-out out-none AY7 SKI Allosteric Type1.5_Back 64 - 507 None None 11
2G1TA 1.8 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 232 - 502 None None 0
2G1TB 1.8 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 230 - 502 None None 0
2G1TC 1.8 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 232 - 507 None None 0
2G1TD 1.8 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 229 - 502 None None 0
7W7XA 2.0 Inactive DFGinter BABtrans in-out out-in 8DW Type1 232 - 500 None X393 0
7W7XB 2.0 Inactive DFGinter BABtrans in-out out-in 8DW Type1 232 - 500 None X393 0
4XEYB 2.891 Inactive DFGinter BABtrans in-out out-in 1N1 Type1 122 - 504 None None 0
7N9GA 2.2 Inactive DFGinter None in-out out-in STI 1N1 Allosteric Type1 233 - 498 None None 13
7N9GC 2.2 Inactive DFGinter None in-none out-in STI 1N1 Allosteric Type1 234 - 499 None None 5
2G2FA 2.7 Inactive DFGinter None in-out out-in No_ligand No_ligand 232 - 506 H396P None 0
6BL8A 2.5 Inactive DFGinter None in-out out-in PVB Type1 233 - 502 None None 0
6BL8B 2.5 Inactive DFGinter None in-none out-in PVB Type1 233 - 504 None None 1
7W7YA 2.2 Inactive DFGinter None in-out out-in 8IW Type1 232 - 500 None X393 0
7W7YB 2.2 Inactive DFGinter None in-out out-in 8IW Type1 232 - 500 None X393 0
8H7FA 2.45 Inactive DFGinter None in-none out-in QEW Type1 232 - 500 None X393 0
8H7FB 2.45 Inactive DFGinter None in-none out-in QEW Type1 233 - 500 None X393 0
8H7HA 2.278 Inactive DFGinter None in-none out-in QH9 Type1 232 - 500 None X393 0
8H7HB 2.278 Inactive DFGinter None in-none out-in QH9 Type1 232 - 500 None X393 0
4ZOGA 2.3 Inactive DFGinter None out-out out-in VX6 Type1 233 - 501 None None 0
7CC2A 2.723 Inactive DFGinter None out-out out-in FVC Type1 233 - 501 None None 0
7CC2B 2.723 Inactive DFGinter None in-none out-in FVC Type1 232 - 501 None None 0
7DT2A 2.3 Inactive DFGinter None in-out out-in HJ9 Type1 233 - 500 None None 0
7DT2B 2.3 Inactive DFGinter None in-out out-in HJ9 Type1 233 - 500 None None 0
2G2HA 2.0 Inactive DFGinter None in-out out-in P16 Type1 233 - 504 H396P None 0
4XEYA 2.891 Inactive DFGinter None in-out out-in 1N1 Type1 231 - 503 None None 0
4YC8A 2.9 Inactive DFGinter None out-none out-in 4B7 Type1.5_Front 233 - 501 None None 0
4YC8B 2.9 Inactive DFGinter None out-none out-in 4B7 Type1.5_Front 233 - 502 None None 0
6XRGA 999.0 Inactive DFGout BBAminus in-in out-in No_ligand No_ligand 229 - 515 G250E,M290L,T389Y None 0
3QRJA 1.82 Inactive DFGout BBAminus in-in out-in 919 Type2 234 - 496 T315I None 0
3QRJB 1.82 Inactive DFGout BBAminus in-in out-in 919 Type2 233 - 497 T315I None 0
2HZ0A 2.1 Inactive DFGout BBAminus in-in out-in GIN Type2 233 - 497 None None 0
2HZ0B 2.1 Inactive DFGout BBAminus in-in none-none GIN Type2 228 - 497 None None 17
2HYYA 2.4 Inactive DFGout BBAminus in-in out-in STI Type2 235 - 498 None None 0
2HYYB 2.4 Inactive DFGout BBAminus in-in out-in STI Type2 233 - 498 None None 0
2HYYC 2.4 Inactive DFGout BBAminus in-in out-in STI Type2 233 - 498 None None 3
2HYYD 2.4 Inactive DFGout BBAminus in-in out-in STI Type2 233 - 498 None None 0
3CS9A 2.21 Inactive DFGout BBAminus in-in out-in NIL Type2 233 - 500 None None 0
3CS9B 2.21 Inactive DFGout BBAminus in-in none-none NIL Type2 233 - 500 None None 18
3CS9C 2.21 Inactive DFGout BBAminus in-in none-none NIL Type2 232 - 497 None None 18
3CS9D 2.21 Inactive DFGout BBAminus in-in out-in NIL Type2 233 - 500 None None 0
3QRIA 2.1 Inactive DFGout BBAminus in-in out-in 919 Type2 229 - 498 None None 0
3QRIB 2.1 Inactive DFGout BBAminus in-in out-in 919 Type2 232 - 498 None None 0
2HIWA 2.2 Inactive DFGout BBAminus in-out out-in 7MP Type2 230 - 499 None None 0
2HIWB 2.2 Inactive DFGout BBAminus in-in out-in 7MP Type2 230 - 499 None None 0
2E2BA 2.2 Inactive DFGout BBAminus in-in out-in 406 Type2 229 - 502 None None 4
2E2BB 2.2 Inactive DFGout BBAminus in-in none-in 406 Type2 229 - 497 None None 6
5HU9A 1.529 Inactive DFGout BBAminus in-in out-out 66K 66K Type2 Allosteric 229 - 499 None None 5
3PYYA 1.85 Inactive DFGout BBAminus in-in out-in STI 3YY Type2 Allosteric 232 - 500 None None 0
3PYYB 1.85 Inactive DFGout BBAminus in-in none-out STI 3YY Type2 Allosteric 233 - 510 None None 15
6NPEA 2.15 Inactive DFGout BBAminus in-in out-in STI KWD Type2 Allosteric 232 - 500 None None 0
6NPEB 2.15 Inactive DFGout BBAminus in-in none-in STI KWD Type2 Allosteric 233 - 511 None None 17
6NPUA 2.33 Inactive DFGout BBAminus in-in out-in STI KWV Type2 Allosteric 232 - 500 None None 0
6NPUB 2.33 Inactive DFGout BBAminus in-in none-in STI KWV Type2 Allosteric 233 - 510 None None 15
6NPVA 1.86 Inactive DFGout BBAminus in-in out-in STI KWP Type2 Allosteric 232 - 500 None None 0
6NPVB 1.86 Inactive DFGout BBAminus in-in none-in STI KWP Type2 Allosteric 233 - 510 None None 15
3QRKA 2.3 Inactive DFGout BBAminus in-in out-in 9DP Type3 229 - 496 None None 0
6XR7A 999.0 Inactive DFGout None in-in out-in No_ligand No_ligand 229 - 515 None None 0
2HZIA 1.7 Inactive DFGout None in-in out-in JIN Type1 233 - 500 None None 0
4ZOGB 2.3 Inactive DFGout None in-in out-in VX6 Type1 234 - 503 None None 2
4WA9B 2.2 Inactive DFGout None in-in out-in AXI Type1 246 - 508 None None 0
3UE4A 2.424 Inactive DFGout None in-out out-in DB8 Type1 233 - 502 None None 0
3UE4B 2.424 Inactive DFGout None in-out out-in DB8 Type1 233 - 502 None None 0
2G2FB 2.7 Inactive DFGout None in-in out-in AGS Type1 234 - 502 H396P None 0
2HZIB 1.7 Inactive DFGout None in-in out-in JIN Type1.5_Back 233 - 500 None None 0
2G2HB 2.0 Inactive DFGout None in-out out-in P16 Type1.5_Back 233 - 504 H396P None 0
2FO0A 2.27 Inactive DFGout None in-in out-in P16 Type1.5_Back 46 - 511 D363N X50 0
1OPLA 3.42 Inactive DFGout None in-in out-in P16 Type1.5_Back 62 - 512 K12R,D363N None 0
1OPLB 3.42 Inactive DFGout None in-in out-in P16 Type1.5_Back 121 - 499 K12R,D363N None 0
5MO4A 2.17 Inactive DFGout None in-in none-out NIL AY7 Type2 Allosteric 64 - 512 None None 18
4WA9A 2.2 Inactive None None none-none out-in AXI Type1 246 - 504 None None 0

ABL1 (Tyrosine-protein kinase ABL1)

Group: TYR
Total number of chains: 127
Spatial Dihedral Chains Representative
DFGin BLAminus 20 AF-P00519-K1A
DFGin BLBplus 6 2G1TA
DFGinter BABtrans 3 7W7XA
DFGinter None 25 2G2HA
DFGout BBAminus 55 3KFAA
DFGout None 16 2HZIA
None None 2 3DK7B
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens ABL1_HUMAN 2HZ4A 2.8 Inactive DFGin BLAminus in-out in-in 4ST Allosteric 234 - 500 None None 0
Homo sapiens ABL1_HUMAN 2HZ4C 2.8 Active DFGin BLAminus in-in in-in 4ST Allosteric 234 - 500 None None 0
Homo sapiens ABL1_HUMAN 7N9GB 2.2 Active DFGin BLAminus in-in in-in STI 1N1 Allosteric Type1 233 - 498 None None 0
Homo sapiens ABL1_HUMAN AF-P00519-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 234 - 503 None None 0
Homo sapiens ABL1_HUMAN 6XR6A 999.0 Inactive DFGin BLAminus in-in out-in No_ligand No_ligand 229 - 515 None None 0
Homo sapiens ABL1_HUMAN 4TWPA 2.4 Active DFGin BLAminus in-in in-in AXI Type1 233 - 503 T315I None 0
Homo sapiens ABL1_HUMAN 4TWPB 2.4 Active DFGin BLAminus in-in in-in AXI Type1 233 - 503 T315I None 0
Homo sapiens ABL1_HUMAN 2V7AA 2.5 Active DFGin BLAminus in-in in-in 627 Type1 233 - 503 T315I X393 0
Homo sapiens ABL1_HUMAN 2V7AB 2.5 Active DFGin BLAminus in-in in-in 627 Type1 234 - 503 T315I X393 0
Homo sapiens ABL1_HUMAN 2HZ4B 2.8 Active DFGin BLAminus in-in in-in 4ST Type1 233 - 498 None None 0
Homo sapiens ABL1_HUMAN 2GQGA 2.4 Active DFGin BLAminus in-in in-in 1N1 Type1 229 - 500 None X393 0
Homo sapiens ABL1_HUMAN 2F4JA 1.91 Active DFGin BLAminus in-in in-in VX6 Type1 227 - 513 H396P None 0
Homo sapiens ABL1_HUMAN 2G2IA 3.12 Active DFGin BLAminus in-in in-in ADP Type1 229 - 502 H396P None 0
Homo sapiens ABL1_HUMAN 2G2IB 3.12 Active DFGin BLAminus in-in in-in ADP Type1 232 - 500 H396P None 0
Homo sapiens ABL1_HUMAN 2GQGB 2.4 Active DFGin BLAminus in-in in-in 1N1 Type1.5_Back 229 - 499 None X393 0
Homo sapiens ABL1_HUMAN 8SSNB 2.86 Inactive DFGin BLBplus out-out none-none AY7 SKI Allosteric Type1 64 - 506 None None 18
Homo sapiens ABL1_HUMAN 8SSNA 2.86 Inactive DFGin BLBplus out-out out-none AY7 SKI Allosteric Type1.5_Back 64 - 507 None None 11
Homo sapiens ABL1_HUMAN 2G1TA 1.8 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 232 - 502 None None 0
Homo sapiens ABL1_HUMAN 2G1TB 1.8 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 230 - 502 None None 0
Homo sapiens ABL1_HUMAN 2G1TC 1.8 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 232 - 507 None None 0
Homo sapiens ABL1_HUMAN 2G1TD 1.8 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 229 - 502 None None 0
Homo sapiens ABL1_HUMAN 7W7XA 2.0 Inactive DFGinter BABtrans in-out out-in 8DW Type1 232 - 500 None X393 0
Homo sapiens ABL1_HUMAN 7W7XB 2.0 Inactive DFGinter BABtrans in-out out-in 8DW Type1 232 - 500 None X393 0
Homo sapiens ABL1_HUMAN 4XEYB 2.891 Inactive DFGinter BABtrans in-out out-in 1N1 Type1 122 - 504 None None 0
Homo sapiens ABL1_HUMAN 7N9GA 2.2 Inactive DFGinter None in-out out-in STI 1N1 Allosteric Type1 233 - 498 None None 13
Homo sapiens ABL1_HUMAN 7N9GC 2.2 Inactive DFGinter None in-none out-in STI 1N1 Allosteric Type1 234 - 499 None None 5
Homo sapiens ABL1_HUMAN 2G2FA 2.7 Inactive DFGinter None in-out out-in No_ligand No_ligand 232 - 506 H396P None 0
Homo sapiens ABL1_HUMAN 6BL8A 2.5 Inactive DFGinter None in-out out-in PVB Type1 233 - 502 None None 0
Homo sapiens ABL1_HUMAN 6BL8B 2.5 Inactive DFGinter None in-none out-in PVB Type1 233 - 504 None None 1
Homo sapiens ABL1_HUMAN 7W7YA 2.2 Inactive DFGinter None in-out out-in 8IW Type1 232 - 500 None X393 0
Homo sapiens ABL1_HUMAN 7W7YB 2.2 Inactive DFGinter None in-out out-in 8IW Type1 232 - 500 None X393 0
Homo sapiens ABL1_HUMAN 8H7FA 2.45 Inactive DFGinter None in-none out-in QEW Type1 232 - 500 None X393 0
Homo sapiens ABL1_HUMAN 8H7FB 2.45 Inactive DFGinter None in-none out-in QEW Type1 233 - 500 None X393 0
Homo sapiens ABL1_HUMAN 8H7HA 2.278 Inactive DFGinter None in-none out-in QH9 Type1 232 - 500 None X393 0
Homo sapiens ABL1_HUMAN 8H7HB 2.278 Inactive DFGinter None in-none out-in QH9 Type1 232 - 500 None X393 0
Homo sapiens ABL1_HUMAN 4ZOGA 2.3 Inactive DFGinter None out-out out-in VX6 Type1 233 - 501 None None 0
Homo sapiens ABL1_HUMAN 7CC2A 2.723 Inactive DFGinter None out-out out-in FVC Type1 233 - 501 None None 0
Homo sapiens ABL1_HUMAN 7CC2B 2.723 Inactive DFGinter None in-none out-in FVC Type1 232 - 501 None None 0
Homo sapiens ABL1_HUMAN 7DT2A 2.3 Inactive DFGinter None in-out out-in HJ9 Type1 233 - 500 None None 0
Homo sapiens ABL1_HUMAN 7DT2B 2.3 Inactive DFGinter None in-out out-in HJ9 Type1 233 - 500 None None 0
Homo sapiens ABL1_HUMAN 2G2HA 2.0 Inactive DFGinter None in-out out-in P16 Type1 233 - 504 H396P None 0
Homo sapiens ABL1_HUMAN 4XEYA 2.891 Inactive DFGinter None in-out out-in 1N1 Type1 231 - 503 None None 0
Homo sapiens ABL1_HUMAN 4YC8A 2.9 Inactive DFGinter None out-none out-in 4B7 Type1.5_Front 233 - 501 None None 0
Homo sapiens ABL1_HUMAN 4YC8B 2.9 Inactive DFGinter None out-none out-in 4B7 Type1.5_Front 233 - 502 None None 0
Homo sapiens ABL1_HUMAN 6XRGA 999.0 Inactive DFGout BBAminus in-in out-in No_ligand No_ligand 229 - 515 G250E,M290L,T389Y None 0
Homo sapiens ABL1_HUMAN 3QRJA 1.82 Inactive DFGout BBAminus in-in out-in 919 Type2 234 - 496 T315I None 0
Homo sapiens ABL1_HUMAN 3QRJB 1.82 Inactive DFGout BBAminus in-in out-in 919 Type2 233 - 497 T315I None 0
Homo sapiens ABL1_HUMAN 2HZ0A 2.1 Inactive DFGout BBAminus in-in out-in GIN Type2 233 - 497 None None 0
Homo sapiens ABL1_HUMAN 2HZ0B 2.1 Inactive DFGout BBAminus in-in none-none GIN Type2 228 - 497 None None 17
Homo sapiens ABL1_HUMAN 2HYYA 2.4 Inactive DFGout BBAminus in-in out-in STI Type2 235 - 498 None None 0
Homo sapiens ABL1_HUMAN 2HYYB 2.4 Inactive DFGout BBAminus in-in out-in STI Type2 233 - 498 None None 0
Homo sapiens ABL1_HUMAN 2HYYC 2.4 Inactive DFGout BBAminus in-in out-in STI Type2 233 - 498 None None 3
Homo sapiens ABL1_HUMAN 2HYYD 2.4 Inactive DFGout BBAminus in-in out-in STI Type2 233 - 498 None None 0
Homo sapiens ABL1_HUMAN 3CS9A 2.21 Inactive DFGout BBAminus in-in out-in NIL Type2 233 - 500 None None 0
Homo sapiens ABL1_HUMAN 3CS9B 2.21 Inactive DFGout BBAminus in-in none-none NIL Type2 233 - 500 None None 18
Homo sapiens ABL1_HUMAN 3CS9C 2.21 Inactive DFGout BBAminus in-in none-none NIL Type2 232 - 497 None None 18
Homo sapiens ABL1_HUMAN 3CS9D 2.21 Inactive DFGout BBAminus in-in out-in NIL Type2 233 - 500 None None 0
Homo sapiens ABL1_HUMAN 3QRIA 2.1 Inactive DFGout BBAminus in-in out-in 919 Type2 229 - 498 None None 0
Homo sapiens ABL1_HUMAN 3QRIB 2.1 Inactive DFGout BBAminus in-in out-in 919 Type2 232 - 498 None None 0
Homo sapiens ABL1_HUMAN 2HIWA 2.2 Inactive DFGout BBAminus in-out out-in 7MP Type2 230 - 499 None None 0
Homo sapiens ABL1_HUMAN 2HIWB 2.2 Inactive DFGout BBAminus in-in out-in 7MP Type2 230 - 499 None None 0
Homo sapiens ABL1_HUMAN 2E2BA 2.2 Inactive DFGout BBAminus in-in out-in 406 Type2 229 - 502 None None 4
Homo sapiens ABL1_HUMAN 2E2BB 2.2 Inactive DFGout BBAminus in-in none-in 406 Type2 229 - 497 None None 6
Homo sapiens ABL1_HUMAN 5HU9A 1.529 Inactive DFGout BBAminus in-in out-out 66K 66K Type2 Allosteric 229 - 499 None None 5
Homo sapiens ABL1_HUMAN 3PYYA 1.85 Inactive DFGout BBAminus in-in out-in STI 3YY Type2 Allosteric 232 - 500 None None 0
Homo sapiens ABL1_HUMAN 3PYYB 1.85 Inactive DFGout BBAminus in-in none-out STI 3YY Type2 Allosteric 233 - 510 None None 15
Homo sapiens ABL1_HUMAN 6NPEA 2.15 Inactive DFGout BBAminus in-in out-in STI KWD Type2 Allosteric 232 - 500 None None 0
Homo sapiens ABL1_HUMAN 6NPEB 2.15 Inactive DFGout BBAminus in-in none-in STI KWD Type2 Allosteric 233 - 511 None None 17
Homo sapiens ABL1_HUMAN 6NPUA 2.33 Inactive DFGout BBAminus in-in out-in STI KWV Type2 Allosteric 232 - 500 None None 0
Homo sapiens ABL1_HUMAN 6NPUB 2.33 Inactive DFGout BBAminus in-in none-in STI KWV Type2 Allosteric 233 - 510 None None 15
Homo sapiens ABL1_HUMAN 6NPVA 1.86 Inactive DFGout BBAminus in-in out-in STI KWP Type2 Allosteric 232 - 500 None None 0
Homo sapiens ABL1_HUMAN 6NPVB 1.86 Inactive DFGout BBAminus in-in none-in STI KWP Type2 Allosteric 233 - 510 None None 15
Homo sapiens ABL1_HUMAN 3QRKA 2.3 Inactive DFGout BBAminus in-in out-in 9DP Type3 229 - 496 None None 0
Homo sapiens ABL1_HUMAN 6XR7A 999.0 Inactive DFGout None in-in out-in No_ligand No_ligand 229 - 515 None None 0
Homo sapiens ABL1_HUMAN 2HZIA 1.7 Inactive DFGout None in-in out-in JIN Type1 233 - 500 None None 0
Homo sapiens ABL1_HUMAN 4ZOGB 2.3 Inactive DFGout None in-in out-in VX6 Type1 234 - 503 None None 2
Homo sapiens ABL1_HUMAN 4WA9B 2.2 Inactive DFGout None in-in out-in AXI Type1 246 - 508 None None 0
Homo sapiens ABL1_HUMAN 3UE4A 2.424 Inactive DFGout None in-out out-in DB8 Type1 233 - 502 None None 0
Homo sapiens ABL1_HUMAN 3UE4B 2.424 Inactive DFGout None in-out out-in DB8 Type1 233 - 502 None None 0
Homo sapiens ABL1_HUMAN 2G2FB 2.7 Inactive DFGout None in-in out-in AGS Type1 234 - 502 H396P None 0
Homo sapiens ABL1_HUMAN 2HZIB 1.7 Inactive DFGout None in-in out-in JIN Type1.5_Back 233 - 500 None None 0
Homo sapiens ABL1_HUMAN 2G2HB 2.0 Inactive DFGout None in-out out-in P16 Type1.5_Back 233 - 504 H396P None 0
Homo sapiens ABL1_HUMAN 2FO0A 2.27 Inactive DFGout None in-in out-in P16 Type1.5_Back 46 - 511 D363N X50 0
Homo sapiens ABL1_HUMAN 1OPLA 3.42 Inactive DFGout None in-in out-in P16 Type1.5_Back 62 - 512 K12R,D363N None 0
Homo sapiens ABL1_HUMAN 1OPLB 3.42 Inactive DFGout None in-in out-in P16 Type1.5_Back 121 - 499 K12R,D363N None 0
Homo sapiens ABL1_HUMAN 5MO4A 2.17 Inactive DFGout None in-in none-out NIL AY7 Type2 Allosteric 64 - 512 None None 18
Homo sapiens ABL1_HUMAN 4WA9A 2.2 Inactive None None none-none out-in AXI Type1 246 - 504 None None 0
Mus musculus ABL1_MOUSE 2Z60A 1.95 Active DFGin BLAminus in-in in-in P3Y Type1 229 - 511 T315I None 0
Mus musculus ABL1_MOUSE 2QOHA 1.95 Active DFGin BLAminus in-in in-in P3Y Type1 229 - 501 None None 0
Mus musculus ABL1_MOUSE 2QOHB 1.95 Active DFGin BLAminus in-in in-in P3Y Type1 229 - 511 None None 0
Mus musculus ABL1_MOUSE 3KF4A 1.9 Active DFGin BLAminus in-in in-in B90 Type1.5_Back 229 - 514 None None 0
Mus musculus ABL1_MOUSE 3KF4B 1.9 Active DFGin BLAminus in-in in-in B90 Type1.5_Back 229 - 501 None None 0
Mus musculus ABL1_MOUSE 3DK7A 2.01 Inactive DFGinter None in-in out-in SX7 Type1 233 - 502 T315I,L445P X393 0
Mus musculus ABL1_MOUSE 3DK6A 2.02 Inactive DFGinter None in-in out-in SX7 Type1 233 - 502 Y253F,L445P X393 0
Mus musculus ABL1_MOUSE 3DK6B 2.02 Inactive DFGinter None in-none out-in SX7 Type1 234 - 505 Y253F,L445P X393 0
Mus musculus ABL1_MOUSE 3DK3A 2.02 Inactive DFGinter None in-in out-in SX7 Type1 233 - 502 Y393F,L445P None 0
Mus musculus ABL1_MOUSE 3DK3B 2.02 Inactive DFGinter None in-in out-in SX7 Type1 233 - 505 Y393F,L445P None 0
Mus musculus ABL1_MOUSE 3K5VA 1.74 Inactive DFGout BBAminus in-in out-in STJ STI Allosteric Type2 229 - 510 None None 0
Mus musculus ABL1_MOUSE 3K5VB 1.74 Inactive DFGout BBAminus in-in out-in STJ STI Allosteric Type2 229 - 510 None None 0
Mus musculus ABL1_MOUSE 6HD4A 2.03 Inactive DFGout BBAminus in-in out-in FYW STI Allosteric Type2 229 - 510 None None 0
Mus musculus ABL1_MOUSE 6HD4B 2.03 Inactive DFGout BBAminus in-in out-in FYW STI Allosteric Type2 229 - 510 None None 0
Mus musculus ABL1_MOUSE 6HD6A 2.3 Inactive DFGout BBAminus in-in out-in FYH STI Allosteric Type2 229 - 510 None None 0
Mus musculus ABL1_MOUSE 3OY3A 1.95 Inactive DFGout BBAminus in-in out-in XY3 Type2 229 - 511 T315I None 0
Mus musculus ABL1_MOUSE 3OY3B 1.95 Inactive DFGout BBAminus in-in out-in XY3 Type2 229 - 511 T315I None 0
Mus musculus ABL1_MOUSE 3IK3A 1.9 Inactive DFGout BBAminus in-in none-in 0LI Type2 229 - 513 T315I None 6
Mus musculus ABL1_MOUSE 3IK3B 1.9 Inactive DFGout BBAminus in-in out-in 0LI Type2 229 - 513 T315I None 0
Mus musculus ABL1_MOUSE 3OXZA 2.2 Inactive DFGout BBAminus in-in none-out 0LI Type2 229 - 511 None None 10
Mus musculus ABL1_MOUSE 3KFAA 1.22 Inactive DFGout BBAminus in-in out-in B91 Type2 229 - 511 None None 0
Mus musculus ABL1_MOUSE 3KFAB 1.22 Inactive DFGout BBAminus in-in out-in B91 Type2 229 - 511 None None 0
Mus musculus ABL1_MOUSE 1FPUA 2.4 Inactive DFGout BBAminus in-in out-in PRC Type2 229 - 499 None None 0
Mus musculus ABL1_MOUSE 1FPUB 2.4 Inactive DFGout BBAminus in-in out-in PRC Type2 229 - 499 None None 5
Mus musculus ABL1_MOUSE 1IEPA 2.1 Inactive DFGout BBAminus in-in out-in STI Type2 229 - 498 None None 0
Mus musculus ABL1_MOUSE 1IEPB 2.1 Inactive DFGout BBAminus in-out out-in STI Type2 229 - 498 None None 0
Mus musculus ABL1_MOUSE 1OPJA 1.75 Inactive DFGout BBAminus in-in out-out STI Type2 229 - 510 None None 0
Mus musculus ABL1_MOUSE 1OPJB 1.75 Inactive DFGout BBAminus in-in out-in STI Type2 229 - 512 None None 0
Mus musculus ABL1_MOUSE 2HZNA 2.7 Inactive DFGout BBAminus in-in out-in KIN Type2 229 - 502 None None 0
Mus musculus ABL1_MOUSE 6HD6B 2.3 Inactive DFGout BBAminus in-in out-in STI Type2 229 - 510 None None 0
Mus musculus ABL1_MOUSE 3MS9A 1.8 Inactive DFGout BBAminus in-in out-in STI MS9 Type2 Allosteric 230 - 498 None None 2
Mus musculus ABL1_MOUSE 3MS9B 1.8 Inactive DFGout BBAminus in-in out-in STI MS9 Type2 Allosteric 229 - 498 None None 0
Mus musculus ABL1_MOUSE 3MSSA 1.95 Inactive DFGout BBAminus in-in out-in STI MS7 Type2 Allosteric 232 - 498 None None 1
Mus musculus ABL1_MOUSE 3MSSB 1.95 Inactive DFGout BBAminus in-in out-in STI MS7 Type2 Allosteric 232 - 498 None None 1
Mus musculus ABL1_MOUSE 3MSSC 1.95 Inactive DFGout BBAminus in-in out-in STI MS7 Type2 Allosteric 232 - 498 None None 1
Mus musculus ABL1_MOUSE 3MSSD 1.95 Inactive DFGout BBAminus in-in out-in STI MS7 Type2 Allosteric 232 - 498 None None 1
Mus musculus ABL1_MOUSE 1M52A 2.6 Inactive DFGout None in-in out-in P17 Type1.5_Back 232 - 502 None None 0
Mus musculus ABL1_MOUSE 1M52B 2.6 Inactive DFGout None in-in out-in P17 Type1.5_Back 232 - 503 None None 0
Mus musculus ABL1_MOUSE 1OPKA 1.8 Inactive DFGout None in-in out-in P16 Type1.5_Back 64 - 512 D363N None 0
Mus musculus ABL1_MOUSE 3DK7B 2.01 Inactive None None in-none out-in SX7 Type1 233 - 505 T315I,L445P X393 0

ABL1 (Tyrosine-protein kinase ABL1)

Group: TYR
Total number of chains: 40
Spatial Dihedral Chains Representative
DFGin BLAminus 5 3KF4B
DFGinter None 5 3DK7A
DFGout BBAminus 26 3KFAA
DFGout None 3 1OPKA
None None 1 3DK7B
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Mus musculus ABL1_MOUSE 2Z60A 1.95 Active DFGin BLAminus in-in in-in P3Y Type1 229 - 511 T315I None 0
Mus musculus ABL1_MOUSE 2QOHA 1.95 Active DFGin BLAminus in-in in-in P3Y Type1 229 - 501 None None 0
Mus musculus ABL1_MOUSE 2QOHB 1.95 Active DFGin BLAminus in-in in-in P3Y Type1 229 - 511 None None 0
Mus musculus ABL1_MOUSE 3KF4A 1.9 Active DFGin BLAminus in-in in-in B90 Type1.5_Back 229 - 514 None None 0
Mus musculus ABL1_MOUSE 3KF4B 1.9 Active DFGin BLAminus in-in in-in B90 Type1.5_Back 229 - 501 None None 0
Mus musculus ABL1_MOUSE 3DK7A 2.01 Inactive DFGinter None in-in out-in SX7 Type1 233 - 502 T315I,L445P X393 0
Mus musculus ABL1_MOUSE 3DK6A 2.02 Inactive DFGinter None in-in out-in SX7 Type1 233 - 502 Y253F,L445P X393 0
Mus musculus ABL1_MOUSE 3DK6B 2.02 Inactive DFGinter None in-none out-in SX7 Type1 234 - 505 Y253F,L445P X393 0
Mus musculus ABL1_MOUSE 3DK3A 2.02 Inactive DFGinter None in-in out-in SX7 Type1 233 - 502 Y393F,L445P None 0
Mus musculus ABL1_MOUSE 3DK3B 2.02 Inactive DFGinter None in-in out-in SX7 Type1 233 - 505 Y393F,L445P None 0
Mus musculus ABL1_MOUSE 3K5VA 1.74 Inactive DFGout BBAminus in-in out-in STJ STI Allosteric Type2 229 - 510 None None 0
Mus musculus ABL1_MOUSE 3K5VB 1.74 Inactive DFGout BBAminus in-in out-in STJ STI Allosteric Type2 229 - 510 None None 0
Mus musculus ABL1_MOUSE 6HD4A 2.03 Inactive DFGout BBAminus in-in out-in FYW STI Allosteric Type2 229 - 510 None None 0
Mus musculus ABL1_MOUSE 6HD4B 2.03 Inactive DFGout BBAminus in-in out-in FYW STI Allosteric Type2 229 - 510 None None 0
Mus musculus ABL1_MOUSE 6HD6A 2.3 Inactive DFGout BBAminus in-in out-in FYH STI Allosteric Type2 229 - 510 None None 0
Mus musculus ABL1_MOUSE 3OY3A 1.95 Inactive DFGout BBAminus in-in out-in XY3 Type2 229 - 511 T315I None 0
Mus musculus ABL1_MOUSE 3OY3B 1.95 Inactive DFGout BBAminus in-in out-in XY3 Type2 229 - 511 T315I None 0
Mus musculus ABL1_MOUSE 3IK3A 1.9 Inactive DFGout BBAminus in-in none-in 0LI Type2 229 - 513 T315I None 6
Mus musculus ABL1_MOUSE 3IK3B 1.9 Inactive DFGout BBAminus in-in out-in 0LI Type2 229 - 513 T315I None 0
Mus musculus ABL1_MOUSE 3OXZA 2.2 Inactive DFGout BBAminus in-in none-out 0LI Type2 229 - 511 None None 10
Mus musculus ABL1_MOUSE 3KFAA 1.22 Inactive DFGout BBAminus in-in out-in B91 Type2 229 - 511 None None 0
Mus musculus ABL1_MOUSE 3KFAB 1.22 Inactive DFGout BBAminus in-in out-in B91 Type2 229 - 511 None None 0
Mus musculus ABL1_MOUSE 1FPUA 2.4 Inactive DFGout BBAminus in-in out-in PRC Type2 229 - 499 None None 0
Mus musculus ABL1_MOUSE 1FPUB 2.4 Inactive DFGout BBAminus in-in out-in PRC Type2 229 - 499 None None 5
Mus musculus ABL1_MOUSE 1IEPA 2.1 Inactive DFGout BBAminus in-in out-in STI Type2 229 - 498 None None 0
Mus musculus ABL1_MOUSE 1IEPB 2.1 Inactive DFGout BBAminus in-out out-in STI Type2 229 - 498 None None 0
Mus musculus ABL1_MOUSE 1OPJA 1.75 Inactive DFGout BBAminus in-in out-out STI Type2 229 - 510 None None 0
Mus musculus ABL1_MOUSE 1OPJB 1.75 Inactive DFGout BBAminus in-in out-in STI Type2 229 - 512 None None 0
Mus musculus ABL1_MOUSE 2HZNA 2.7 Inactive DFGout BBAminus in-in out-in KIN Type2 229 - 502 None None 0
Mus musculus ABL1_MOUSE 6HD6B 2.3 Inactive DFGout BBAminus in-in out-in STI Type2 229 - 510 None None 0
Mus musculus ABL1_MOUSE 3MS9A 1.8 Inactive DFGout BBAminus in-in out-in STI MS9 Type2 Allosteric 230 - 498 None None 2
Mus musculus ABL1_MOUSE 3MS9B 1.8 Inactive DFGout BBAminus in-in out-in STI MS9 Type2 Allosteric 229 - 498 None None 0
Mus musculus ABL1_MOUSE 3MSSA 1.95 Inactive DFGout BBAminus in-in out-in STI MS7 Type2 Allosteric 232 - 498 None None 1
Mus musculus ABL1_MOUSE 3MSSB 1.95 Inactive DFGout BBAminus in-in out-in STI MS7 Type2 Allosteric 232 - 498 None None 1
Mus musculus ABL1_MOUSE 3MSSC 1.95 Inactive DFGout BBAminus in-in out-in STI MS7 Type2 Allosteric 232 - 498 None None 1
Mus musculus ABL1_MOUSE 3MSSD 1.95 Inactive DFGout BBAminus in-in out-in STI MS7 Type2 Allosteric 232 - 498 None None 1
Mus musculus ABL1_MOUSE 1M52A 2.6 Inactive DFGout None in-in out-in P17 Type1.5_Back 232 - 502 None None 0
Mus musculus ABL1_MOUSE 1M52B 2.6 Inactive DFGout None in-in out-in P17 Type1.5_Back 232 - 503 None None 0
Mus musculus ABL1_MOUSE 1OPKA 1.8 Inactive DFGout None in-in out-in P16 Type1.5_Back 64 - 512 D363N None 0
Mus musculus ABL1_MOUSE 3DK7B 2.01 Inactive None None in-none out-in SX7 Type1 233 - 505 T315I,L445P X393 0