EPHB4 (Ephrin type-B receptor 4)

Group: TYR
Uniprot: EPHB4_HUMAN
Domain boundary: 615 - 876


Total number of chains: 23
Spatial Dihedral Chains Representative
DFGin BLAminus 4 AF-P54760-K1A
DFGin BLBminus 11 6FNKA
DFGin None 5 2YN8B
DFGout BBAminus 3 6FNJA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
6FNLA 1.269 None DFGin BLAminus in-in none-in No_ligand No_ligand 607 - 888 Y774E,A803V,V870I None 20
AF-P54760-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 607 - 884 None None 0
3ZEWA 2.5 Active DFGin BLAminus in-in in-in STU Type1 609 - 888 None X774 6
3ZEWB 2.5 None DFGin BLAminus in-none none-in STU Type1 609 - 887 None X774 21
6FNKA 1.049 Inactive DFGin BLBminus in-in out-in DXK Type1 604 - 889 Y774E,A803V,V870I None 12
6FNMA 1.157 Inactive DFGin BLBminus in-in out-in 1N1 Type1 608 - 889 Y774E,A803V,V870I None 12
4AW5A 2.33 Inactive DFGin BLBminus in-in none-in 30K Type1 607 - 888 None None 21
2VWXA 1.65 Inactive DFGin BLBminus in-in out-in 7X4 Type1 608 - 888 Y774E None 7
2VWYA 1.65 Inactive DFGin BLBminus in-in out-in 7X5 Type1 608 - 888 Y774E None 7
2VWZA 1.65 Inactive DFGin BLBminus in-in out-in 7X6 Type1 608 - 888 Y774E None 7
2VX0A 2.1 Inactive DFGin BLBminus in-in out-in 7X7 Type1 608 - 888 Y774E None 8
2VX1A 1.65 Inactive DFGin BLBminus in-in out-in 7X8 Type1 608 - 888 Y774E None 7
2X9FA 1.75 Inactive DFGin BLBminus in-in out-in X9F Type1 608 - 888 Y774E None 13
4BB4A 1.65 Inactive DFGin BLBminus in-in out-in 32W Type1 606 - 888 Y774E None 15
2XVDA 1.7 Inactive DFGin BLBminus in-in out-in AS6 Type1.5_Back 607 - 888 Y774E None 9
2YN8A 2.11 Inactive DFGin None in-in none-none STU Type1 608 - 888 Y774E,A803V,V870I None 23
2YN8B 2.11 Inactive DFGin None in-in none-none STU Type1 606 - 888 Y774E,A803V,V870I None 23
2VWUA 2.0 Inactive DFGin None in-in none-in 7X1 Type1 609 - 887 Y774E None 22
2VWVA 1.9 Inactive DFGin None in-in none-in 7X3 Type1 606 - 885 Y774E None 21
2VWWA 1.9 Inactive DFGin None in-in none-in 7X2 Type1 609 - 887 Y774E None 22
6FNIA 1.468 Inactive DFGout BBAminus in-in out-out DXH Type2 607 - 889 Y774E,A803V,V870I None 17
6FNJA 1.239 Inactive DFGout BBAminus in-in none-out DWT Type2 607 - 888 Y774E,A803V,V870I None 20
6FNJB 1.239 Inactive DFGout BBAminus in-in none-out DWT Type2 607 - 888 Y774E,A803V,V870I None 20

EPHB4 (Ephrin type-B receptor 4)

Group: TYR
Total number of chains: 23
Spatial Dihedral Chains Representative
DFGin BLAminus 4 AF-P54760-K1A
DFGin BLBminus 11 6FNKA
DFGin None 5 2YN8B
DFGout BBAminus 3 6FNJA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens EPHB4_HUMAN 6FNLA 1.269 None DFGin BLAminus in-in none-in No_ligand No_ligand 607 - 888 Y774E,A803V,V870I None 20
Homo sapiens EPHB4_HUMAN AF-P54760-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 607 - 884 None None 0
Homo sapiens EPHB4_HUMAN 3ZEWA 2.5 Active DFGin BLAminus in-in in-in STU Type1 609 - 888 None X774 6
Homo sapiens EPHB4_HUMAN 3ZEWB 2.5 None DFGin BLAminus in-none none-in STU Type1 609 - 887 None X774 21
Homo sapiens EPHB4_HUMAN 6FNKA 1.049 Inactive DFGin BLBminus in-in out-in DXK Type1 604 - 889 Y774E,A803V,V870I None 12
Homo sapiens EPHB4_HUMAN 6FNMA 1.157 Inactive DFGin BLBminus in-in out-in 1N1 Type1 608 - 889 Y774E,A803V,V870I None 12
Homo sapiens EPHB4_HUMAN 4AW5A 2.33 Inactive DFGin BLBminus in-in none-in 30K Type1 607 - 888 None None 21
Homo sapiens EPHB4_HUMAN 2VWXA 1.65 Inactive DFGin BLBminus in-in out-in 7X4 Type1 608 - 888 Y774E None 7
Homo sapiens EPHB4_HUMAN 2VWYA 1.65 Inactive DFGin BLBminus in-in out-in 7X5 Type1 608 - 888 Y774E None 7
Homo sapiens EPHB4_HUMAN 2VWZA 1.65 Inactive DFGin BLBminus in-in out-in 7X6 Type1 608 - 888 Y774E None 7
Homo sapiens EPHB4_HUMAN 2VX0A 2.1 Inactive DFGin BLBminus in-in out-in 7X7 Type1 608 - 888 Y774E None 8
Homo sapiens EPHB4_HUMAN 2VX1A 1.65 Inactive DFGin BLBminus in-in out-in 7X8 Type1 608 - 888 Y774E None 7
Homo sapiens EPHB4_HUMAN 2X9FA 1.75 Inactive DFGin BLBminus in-in out-in X9F Type1 608 - 888 Y774E None 13
Homo sapiens EPHB4_HUMAN 4BB4A 1.65 Inactive DFGin BLBminus in-in out-in 32W Type1 606 - 888 Y774E None 15
Homo sapiens EPHB4_HUMAN 2XVDA 1.7 Inactive DFGin BLBminus in-in out-in AS6 Type1.5_Back 607 - 888 Y774E None 9
Homo sapiens EPHB4_HUMAN 2YN8A 2.11 Inactive DFGin None in-in none-none STU Type1 608 - 888 Y774E,A803V,V870I None 23
Homo sapiens EPHB4_HUMAN 2YN8B 2.11 Inactive DFGin None in-in none-none STU Type1 606 - 888 Y774E,A803V,V870I None 23
Homo sapiens EPHB4_HUMAN 2VWUA 2.0 Inactive DFGin None in-in none-in 7X1 Type1 609 - 887 Y774E None 22
Homo sapiens EPHB4_HUMAN 2VWVA 1.9 Inactive DFGin None in-in none-in 7X3 Type1 606 - 885 Y774E None 21
Homo sapiens EPHB4_HUMAN 2VWWA 1.9 Inactive DFGin None in-in none-in 7X2 Type1 609 - 887 Y774E None 22
Homo sapiens EPHB4_HUMAN 6FNIA 1.468 Inactive DFGout BBAminus in-in out-out DXH Type2 607 - 889 Y774E,A803V,V870I None 17
Homo sapiens EPHB4_HUMAN 6FNJA 1.239 Inactive DFGout BBAminus in-in none-out DWT Type2 607 - 888 Y774E,A803V,V870I None 20
Homo sapiens EPHB4_HUMAN 6FNJB 1.239 Inactive DFGout BBAminus in-in none-out DWT Type2 607 - 888 Y774E,A803V,V870I None 20

EPHB4 (Ephrin type-B receptor 4)

No non-human structures known.