TKL_ACVR1 (Activin receptor type-1)

Total number of chains: 163
Active chains: 2
Family: TKL
Uniprot: ACVR1_HUMAN
Kinase Domain Residues: 208 - 497
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 156 95.7% AF-Q04771-K1A
DFGin ABAminus 6 3.7% 6T6DB
DFGin None 1 0.6% 6T6DA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-Q04771-K1A 200 505 509.0 No_ligand No_ligand Active DFGin 6.656 13.526 BLAminus -127.2, 176.62 56.35, 65.16 -80.71, 13.41 298.31, 0.47 -60.59, -18.71 in-in in 8.385 Saltbr-in 2.736 HRD-in -74.03, -41.1 65.71, -12.96 in-in-in SNCiii in-in ActLoopNT-in 2.861 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.22, 163.47 APE9-dihe-na 104.77, -176.02 APE8-dihe-in -80.82, 114.57 APE8-rot-in 305.54 APE67-dihe-in -59.76, -26.02 -45.29, -43.62 APE12-dist-in 11.402 APE11-dist-in 12.036 APE10-dist-in 6.213 APE9-dist-in 3.882 None None None AF2 -1.0 1.0 1.0 A 306 306 0 0 0 0 [[207, 497]] 1.0 AF-Q04771-K1 TKL_ACVR1_HUMAN TKL 2e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
AF-Q04771-K3A 200 505 509.0 No_ligand No_ligand Active DFGin 6.82 13.024 BLAminus -127.84, -178.84 55.95, 50.54 -70.42, 5.27 299.08, 177.61 -61.12, -20.07 in-in in 7.973 Saltbr-in 2.703 HRD-in -75.32, -37.69 63.01, -26.16 in-in-in SNCiii in-in ActLoopNT-in 2.804 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.49, 160.87 APE9-dihe-na 125.45, 177.41 APE8-dihe-in -88.62, 117.29 APE8-rot-in 301.68 APE67-dihe-in -61.23, -22.08 -39.68, -47.95 APE12-dist-in 10.723 APE11-dist-in 11.388 APE10-dist-in 5.761 APE9-dist-in 3.877 None None None AF2 -1.0 1.0 1.0 A 306 306 0 0 0 0 [[207, 497]] 1.0 AF-Q04771-K3 TKL_ACVR1_HUMAN TKL 2e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6T6DB 203 499 509.0 MM8:501 Type1 Inactive DFGin 8.025 13.457 ABAminus -113.12, -72.46 -79.26, 114.59 -109.76, 17.95 287.15, 78.17 -59.58, -33.57 in-out in 8.222 Saltbr-out 4.023 HRD-in -73.05, -64.25 87.23, -2.54 out-in-out SNCoio in-out ActLoopNT-in 2.974 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -123.53, 156.31 APE9-dihe-na -60.36, 167.63 APE8-dihe-in -59.61, 127.94 APE8-rot-in 305.34 APE67-dihe-in -62.73, -26.34 -66.57, -31.38 APE12-dist-in 10.822 APE11-dist-out 6.699 APE10-dist-out 8.867 APE9-dist-in 3.884 Q207D None None XRAY 2.56 0.224 0.272 B 301 297 0 0 0 0 [[207, 497]] 1.0 6t6d TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6T6DC 205 498 509.0 MM8:501 Type1 Inactive DFGin 7.871 12.593 ABAminus -116.62, -62.87 -95.88, 111.8 -114.2, 22.29 305.51, 0.83 -66.78, -30.11 in-out in 8.065 Saltbr-out 3.808 HRD-in -69.93, -68.13 91.02, -5.92 out-in-in SNCoii in-in ActLoopNT-in 2.828 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -97.68, 140.63 APE9-dihe-na 133.68, 172.6 APE8-dihe-in -72.52, 124.22 APE8-rot-in 299.66 APE67-dihe-in -70.69, -22.05 -69.0, -25.51 APE12-dist-in 11.262 APE11-dist-in 12.36 APE10-dist-in 6.63 APE9-dist-in 4.218 Q207D None None XRAY 2.56 0.224 0.272 C 301 278 16 0 0 11 [[207, 497]] 1.0 6t6d TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6ZGCA 205 499 509.0 H8H:501 Type1 Inactive DFGin 7.681 12.708 ABAminus -107.89, -60.92 -94.08, 111.73 -110.3, 16.97 303.67, 166.99 -67.99, -29.57 in-out in 8.661 Saltbr-out 4.532 HRD-in -76.83, -55.96 76.97, 3.64 out-in-in SNCoii in-in ActLoopNT-in 2.903 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -97.86, 149.98 APE9-dihe-na 117.18, 157.89 APE8-dihe-in -61.4, 123.56 APE8-rot-in 297.81 APE67-dihe-in -59.38, -25.03 -58.82, -36.53 APE12-dist-in 12.254 APE11-dist-in 12.368 APE10-dist-in 6.635 APE9-dist-in 4.243 Q207D None None XRAY 2.67 0.215 0.26 A 301 292 3 0 0 3 [[207, 497]] 1.0 6zgc TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6ZGCB 203 499 509.0 H8H:501 Type1 Inactive DFGin 8.059 13.076 ABAminus -110.37, -58.89 -92.47, 102.08 -108.51, 23.12 297.16, 160.33 -68.67, -30.3 in-out in 8.509 Saltbr-out 4.089 HRD-in -75.39, -56.68 79.53, 2.12 out-in-none SNCoin in-none ActLoopNT-in 3.057 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -104.09, -8.88 APE9-dihe-na -69.88, 178.01 APE8-dihe-in -69.34, 130.54 APE8-rot-in 309.97 APE67-dihe-in -59.99, -26.01 -62.71, -39.0 APE12-dist-none 999.0 APE11-dist-in 11.498 APE10-dist-in 6.693 APE9-dist-in 3.953 Q207D None None XRAY 2.67 0.215 0.26 B 301 291 6 0 0 5 [[207, 497]] 1.0 6zgc TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6ZGCC 201 498 509.0 H8H:501 Type1 Inactive DFGin 7.649 13.123 ABAminus -111.55, -59.07 -96.03, 103.07 -100.54, 20.17 312.53, 170.02 -62.85, -32.84 in-none in 8.718 Saltbr-none 999.0 HRD-in -78.56, -58.95 79.27, 6.55 none-in-out SNCnio in-out ActLoopNT-in 3.034 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -126.95, 173.39 APE9-dihe-na -60.53, 177.19 APE8-dihe-in -72.99, 133.32 APE8-rot-in 299.82 APE67-dihe-in -70.68, -22.46 -67.18, -24.36 APE12-dist-in 10.374 APE11-dist-out 7.487 APE10-dist-out 8.462 APE9-dist-in 3.917 Q207D None None XRAY 2.67 0.215 0.26 C 301 296 2 0 0 2 [[207, 497]] 1.0 6zgc TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6ZGCD 203 498 509.0 H8H:501 Type1 Inactive DFGin 8.129 12.987 ABAminus -118.4, -60.05 -92.31, 105.89 -107.46, 26.29 296.86, 166.24 -65.26, -28.18 in-out in 8.401 Saltbr-out 3.987 HRD-in -73.86, -57.34 80.97, -1.67 out-in-in SNCoii in-in ActLoopNT-in 3.024 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.47, 108.31 APE9-dihe-na 164.09, 161.61 APE8-dihe-in -63.97, 128.7 APE8-rot-in 301.77 APE67-dihe-in -60.64, -22.49 -67.87, -34.64 APE12-dist-in 12.5 APE11-dist-in 11.852 APE10-dist-in 6.463 APE9-dist-in 4.033 Q207D None None XRAY 2.67 0.215 0.26 D 301 291 5 0 0 3 [[207, 497]] 1.0 6zgc TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6UNQA 206 496 509.0 ANP:501 ATPlike Inactive DFGin 7.42 13.337 BLAminus -125.65, 175.43 76.87, 82.94 -97.73, 22.73 293.77, 158.03 -74.66, -11.32 in-out in 8.409 Saltbr-out 4.371 HRD-in -82.52, -56.03 82.09, -4.01 out-in-out SNCoio in-out ActLoopNT-in 2.814 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.89, 171.23 APE9-dihe-na -69.6, 161.61 APE8-dihe-in -54.69, 120.18 APE8-rot-in 304.53 APE67-dihe-in -58.55, -27.57 -58.47, -38.91 APE12-dist-in 10.463 APE11-dist-out 6.668 APE10-dist-out 9.075 APE9-dist-in 3.923 K493A None None XRAY 2.4 0.221 0.283 A 330 289 3 0 0 0 [[207, 497]] 1.0 6unq TKL_ACVR1_HUMAN TKL 5e-85 291.3 2 266 265 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6UNRA 208 496 509.0 ANP:501 ATPlike Inactive DFGin 7.292 13.342 BLAminus -137.01, 173.22 63.77, 86.25 -97.63, 26.62 300.72, 163.44 -66.11, -21.39 in-out in 8.4 Saltbr-out 4.744 HRD-in -74.93, -61.2 87.34, -7.73 out-in-out SNCoio in-out ActLoopNT-in 2.837 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -115.39, 160.07 APE9-dihe-na -63.13, 170.03 APE8-dihe-in -59.34, 121.87 APE8-rot-in 302.11 APE67-dihe-in -65.55, -35.42 -57.38, -33.57 APE12-dist-in 10.451 APE11-dist-out 6.838 APE10-dist-out 9.11 APE9-dist-in 3.93 None None None XRAY 2.2 0.246 0.302 A 330 286 4 0 0 0 [[207, 497]] 1.0 6unr TKL_ACVR1_HUMAN TKL 7.3e-85 290.8 2 266 265 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6SZMA 202 499 509.0 M2Z:501,M2Z:502,M2Z:503 Allosteric,Allosteric,Type1 Inactive DFGin 8.373 13.383 BLAminus -123.47, 160.72 76.41, 88.39 -99.15, 24.41 296.86, 175.6 -67.43, -19.78 in-out in 9.11 Saltbr-out 5.906 HRD-in -80.16, -50.98 77.51, 1.34 out-in-out SNCoio in-out ActLoopNT-in 2.898 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -127.99, 159.14 APE9-dihe-na -78.06, -171.02 APE8-dihe-in -67.19, 128.07 APE8-rot-in 301.51 APE67-dihe-in -54.87, -30.28 -61.82, -41.68 APE12-dist-in 10.132 APE11-dist-out 6.41 APE10-dist-out 9.299 APE9-dist-in 3.64 None None None XRAY 1.42 0.154 0.188 A 301 288 10 0 0 10 [[207, 497]] 1.0 6szm TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7QB 205 499 509.0 XJM:1801,LU8:1802,XJM:1806 Allosteric,Type1,Allosteric Inactive DFGin 7.035 13.341 BLAminus -124.49, 160.57 78.3, 88.59 -102.07, 16.77 299.19, 176.61 -55.48, -25.66 in-out in 8.607 Saltbr-out 4.501 HRD-in -84.23, -49.81 75.94, -2.06 out-in-out SNCoio in-out ActLoopNT-in 2.885 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -124.81, 167.47 APE9-dihe-na -59.06, 164.28 APE8-dihe-in -59.12, 123.47 APE8-rot-in 303.32 APE67-dihe-in -63.13, -25.62 -55.86, -41.03 APE12-dist-in 10.295 APE11-dist-out 6.507 APE10-dist-out 8.84 APE9-dist-in 3.744 Q207D None None XRAY 1.53 0.209 0.243 B 301 291 4 0 0 0 [[207, 497]] 1.0 5s7q TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6JUXA 203 499 509.0 C9U:501 Type1 Inactive DFGin 7.497 12.961 BLAminus -126.78, 178.97 70.86, 74.4 -92.99, 19.92 304.1, 176.2 -79.32, -9.69 in-out in 8.714 Saltbr-out 4.2 HRD-in -86.87, -53.36 72.97, 4.05 out-in-out SNCoio in-out ActLoopNT-in 2.893 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -115.09, 166.4 APE9-dihe-na -51.77, 159.85 APE8-dihe-in -52.34, 120.21 APE8-rot-in 308.99 APE67-dihe-in -56.94, -33.63 -55.65, -42.66 APE12-dist-in 10.485 APE11-dist-out 6.522 APE10-dist-out 9.018 APE9-dist-in 3.909 R206H None None XRAY 1.75 0.196 0.226 A 299 295 2 0 0 0 [[207, 497]] 1.0 6jux TKL_ACVR1_HUMAN TKL 1.7e-85 292.7 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
4DYMA 207 499 509.0 IYZ:503 Type1 Inactive DFGin 7.35 12.994 BLAminus -95.12, 171.56 68.54, 94.25 -112.58, 21.32 293.39, 167.99 -72.08, -14.94 in-out in 8.886 Saltbr-out 4.563 HRD-in -84.9, -47.48 69.85, 4.05 out-in-out SNCoio in-out ActLoopNT-in 2.964 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -117.83, 177.0 APE9-dihe-na -52.44, -173.58 APE8-dihe-in -89.42, 123.68 APE8-rot-in 308.16 APE67-dihe-in -62.72, -31.35 -61.06, -26.38 APE12-dist-in 10.743 APE11-dist-out 6.841 APE10-dist-out 9.124 APE9-dist-in 3.91 R206H None None XRAY 2.42 0.271 0.279 A 301 293 0 0 0 0 [[207, 497]] 1.0 4dym TKL_ACVR1_HUMAN TKL 1.8e-85 292.7 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6ACRA 203 498 509.0 9TO:501 Type1 Inactive DFGin 7.153 13.11 BLAminus -124.89, 170.02 71.35, 87.97 -99.79, 21.94 299.39, 166.61 -70.31, -13.55 in-out in 8.337 Saltbr-out 4.013 HRD-in -84.47, -53.43 78.41, -0.38 out-in-out SNCoio in-out ActLoopNT-in 2.899 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -116.18, 166.2 APE9-dihe-na -63.37, 165.5 APE8-dihe-in -62.27, 124.69 APE8-rot-in 304.34 APE67-dihe-in -61.96, -28.37 -60.94, -34.65 APE12-dist-in 10.548 APE11-dist-out 6.525 APE10-dist-out 9.133 APE9-dist-in 3.985 R206H None None XRAY 2.01 0.215 0.257 A 301 294 2 0 0 0 [[207, 497]] 1.0 6acr TKL_ACVR1_HUMAN TKL 1.8e-85 292.7 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6ACRB 203 498 509.0 9TO:501 Type1 Inactive DFGin 7.378 13.12 BLAminus -127.75, 173.06 71.61, 79.74 -95.63, 20.34 301.12, 177.54 -68.09, -20.68 in-out in 8.546 Saltbr-out 4.317 HRD-in -78.48, -57.97 79.82, 2.93 out-in-out SNCoio in-out ActLoopNT-in 2.791 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -124.88, 159.1 APE9-dihe-na -64.17, 165.67 APE8-dihe-in -58.46, 129.98 APE8-rot-in 315.31 APE67-dihe-in -57.05, -29.95 -67.86, -34.69 APE12-dist-in 10.53 APE11-dist-out 6.373 APE10-dist-out 8.876 APE9-dist-in 4.015 R206H None None XRAY 2.01 0.215 0.257 B 301 293 3 0 0 0 [[207, 497]] 1.0 6acr TKL_ACVR1_HUMAN TKL 1.8e-85 292.7 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
7C3GA 203 499 509.0 FH0:501 Type1 Inactive DFGin 7.452 13.12 BLAminus -120.29, 176.78 74.55, 68.82 -92.53, 16.09 299.06, 172.08 -68.72, -15.02 in-out in 8.748 Saltbr-out 3.982 HRD-in -78.99, -54.41 81.04, -2.4 out-in-out SNCoio in-out ActLoopNT-in 2.944 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -116.93, 167.94 APE9-dihe-na -56.86, 161.03 APE8-dihe-in -55.72, 122.04 APE8-rot-in 306.26 APE67-dihe-in -62.08, -30.46 -57.68, -38.77 APE12-dist-in 10.473 APE11-dist-out 6.36 APE10-dist-out 9.024 APE9-dist-in 3.996 R206H None None XRAY 1.802 0.187 0.227 A 301 294 3 0 0 0 [[207, 497]] 1.0 7c3g TKL_ACVR1_HUMAN TKL 1.8e-85 292.7 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
7C3GB 204 499 509.0 FH0:501 Type1 Inactive DFGin 7.609 13.325 BLAminus -125.84, 177.88 70.8, 71.42 -95.2, 21.82 292.6, 168.16 -65.11, -21.81 in-out in 8.748 Saltbr-out 4.465 HRD-in -77.19, -58.48 86.47, -3.16 out-in-out SNCoio in-out ActLoopNT-in 2.933 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -115.68, 164.55 APE9-dihe-na -56.41, 161.05 APE8-dihe-in -56.53, 124.69 APE8-rot-in 304.77 APE67-dihe-in -57.59, -33.55 -59.78, -42.88 APE12-dist-in 10.404 APE11-dist-out 6.359 APE10-dist-out 9.141 APE9-dist-in 4.074 R206H None None XRAY 1.802 0.187 0.227 B 301 292 4 0 0 0 [[207, 497]] 1.0 7c3g TKL_ACVR1_HUMAN TKL 1.8e-85 292.7 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
9L04A 203 499 509.0 A1L4C:501 Type1 Inactive DFGin 7.479 12.86 BLAminus -130.06, 174.39 69.49, 74.26 -93.18, 21.09 300.59, 12.81 -75.51, -18.04 in-out in 8.739 Saltbr-out 4.258 HRD-in -79.89, -55.04 80.17, -0.76 out-in-out SNCoio in-out ActLoopNT-in 2.844 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -113.16, 168.0 APE9-dihe-na -69.82, 167.07 APE8-dihe-in -55.37, 129.02 APE8-rot-in 307.55 APE67-dihe-in -52.45, -37.7 -69.98, -38.93 APE12-dist-in 10.484 APE11-dist-out 6.341 APE10-dist-out 8.894 APE9-dist-in 4.098 R206H None None XRAY 2.25 0.198 0.256 A 301 295 2 0 0 0 [[207, 497]] 1.0 9l04 TKL_ACVR1_HUMAN TKL 1.8e-85 292.7 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
3MTFA 203 498 509.0 A3F:1 Type1 Inactive DFGin 7.09 13.208 BLAminus -126.1, 157.67 76.9, 82.69 -86.05, 21.36 306.23, 175.03 -61.66, -24.97 in-out in 8.331 Saltbr-out 4.196 HRD-in -82.54, -58.57 79.29, -1.49 out-in-out SNCoio in-out ActLoopNT-in 2.913 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -103.22, 162.67 APE9-dihe-na -69.88, 165.81 APE8-dihe-in -53.93, 121.99 APE8-rot-in 312.82 APE67-dihe-in -59.42, -28.32 -57.34, -37.41 APE12-dist-in 10.671 APE11-dist-out 6.476 APE10-dist-out 9.482 APE9-dist-in 4.073 Q207D None None XRAY 2.15 0.185 0.244 A 301 296 0 0 0 0 [[207, 497]] 1.0 3mtf TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
3MTFB 202 499 509.0 A3F:501 Type1 Inactive DFGin 7.578 13.323 BLAminus -114.45, 160.06 82.35, 87.49 -104.83, 25.86 291.12, 164.81 -75.29, -13.54 in-out in 8.5 Saltbr-out 4.232 HRD-in -82.5, -60.12 85.3, -4.39 out-in-out SNCoio in-out ActLoopNT-in 2.869 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -111.75, 153.3 APE9-dihe-na -57.45, 170.81 APE8-dihe-in -65.39, 131.64 APE8-rot-in 306.28 APE67-dihe-in -49.77, -35.33 -68.1, -43.23 APE12-dist-in 10.611 APE11-dist-out 6.453 APE10-dist-out 9.396 APE9-dist-in 4.119 Q207D None None XRAY 2.15 0.185 0.244 B 301 298 0 0 0 0 [[207, 497]] 1.0 3mtf TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
3OOMA 203 499 509.0 507:500 Type1 Inactive DFGin 7.508 13.124 BLAminus -119.72, 175.77 64.93, 85.25 -99.67, 23.22 296.73, 169.75 -72.64, -17.83 in-out in 8.556 Saltbr-out 4.701 HRD-in -77.48, -54.35 75.93, -1.97 out-in-out SNCoio in-out ActLoopNT-in 2.853 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.69, 161.89 APE9-dihe-na -56.15, 170.97 APE8-dihe-in -64.03, 124.65 APE8-rot-in 303.79 APE67-dihe-in -53.45, -34.26 -59.83, -42.52 APE12-dist-in 10.503 APE11-dist-out 6.516 APE10-dist-out 9.005 APE9-dist-in 3.811 Q207D None None XRAY 2.0 0.169 0.231 A 301 297 0 0 0 0 [[207, 497]] 1.0 3oom TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
3Q4UA 202 499 509.0 LDN:60003 Type1 Inactive DFGin 7.478 12.573 BLAminus -120.84, 173.99 68.96, 74.22 -93.95, 15.54 311.32, 10.07 -71.11, -14.74 in-out in 8.549 Saltbr-out 4.579 HRD-in -84.93, -53.09 80.07, -4.32 out-in-out SNCoio in-out ActLoopNT-in 2.789 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -114.63, 164.37 APE9-dihe-na -65.59, 171.9 APE8-dihe-in -66.34, 131.05 APE8-rot-in 305.21 APE67-dihe-in -57.96, -32.78 -63.26, -38.88 APE12-dist-in 10.559 APE11-dist-out 6.57 APE10-dist-out 9.207 APE9-dist-in 3.828 Q207D None None XRAY 1.82 0.166 0.219 A 301 298 0 0 0 0 [[207, 497]] 1.0 3q4u TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
3Q4UB 201 498 509.0 LDN:60001 Type1 Inactive DFGin 7.387 12.685 BLAminus -120.34, 167.09 70.32, 85.15 -102.45, 24.25 310.23, 168.4 -65.43, -24.12 in-out in 8.482 Saltbr-out 5.14 HRD-in -76.75, -51.74 78.96, -3.77 out-in-out SNCoio in-out ActLoopNT-in 2.844 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.85, -163.35 APE9-dihe-na -81.08, 171.54 APE8-dihe-in -58.97, 129.56 APE8-rot-in 295.83 APE67-dihe-in -56.37, -27.71 -54.93, -46.2 APE12-dist-in 11.088 APE11-dist-out 6.775 APE10-dist-out 8.729 APE9-dist-in 3.515 Q207D None None XRAY 1.82 0.166 0.219 B 301 298 0 0 0 0 [[207, 497]] 1.0 3q4u TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
3Q4UC 204 499 509.0 LDN:60004 Type1 Inactive DFGin 7.801 12.909 BLAminus -120.15, 175.41 62.84, 82.09 -94.65, 16.97 298.1, 171.75 -63.36, -27.43 in-out in 8.263 Saltbr-out 4.168 HRD-in -78.97, -53.49 75.91, -2.19 out-in-out SNCoio in-out ActLoopNT-in 2.911 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -111.55, 159.31 APE9-dihe-na -59.78, 170.44 APE8-dihe-in -70.45, 124.67 APE8-rot-in 303.37 APE67-dihe-in -52.43, -35.98 -60.31, -42.57 APE12-dist-in 10.679 APE11-dist-out 6.711 APE10-dist-out 9.362 APE9-dist-in 4.195 Q207D None None XRAY 1.82 0.166 0.219 C 301 296 0 0 0 0 [[207, 497]] 1.0 3q4u TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
3Q4UD 201 499 509.0 LDN:60002 Type1 Inactive DFGin 7.511 12.944 BLAminus -125.12, 175.24 65.52, 81.22 -96.12, 21.65 304.54, 179.82 -68.03, -22.84 in-out in 8.467 Saltbr-out 4.271 HRD-in -81.0, -52.46 76.02, -4.8 out-in-out SNCoio in-out ActLoopNT-in 2.84 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -113.41, 168.67 APE9-dihe-na -64.59, 163.68 APE8-dihe-in -59.61, 131.17 APE8-rot-in 305.46 APE67-dihe-in -53.27, -32.89 -61.06, -44.5 APE12-dist-in 10.69 APE11-dist-out 6.985 APE10-dist-out 9.135 APE9-dist-in 4.035 Q207D None None XRAY 1.82 0.166 0.219 D 301 299 0 0 0 0 [[207, 497]] 1.0 3q4u TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
4BGGA 203 498 509.0 844:1000 Type1 Inactive DFGin 7.696 13.012 BLAminus -123.75, 169.71 65.78, 89.27 -103.09, 23.33 302.35, 172.22 -60.21, -27.36 in-out in 8.613 Saltbr-out 4.459 HRD-in -75.04, -56.75 78.1, 3.09 out-in-out SNCoio in-out ActLoopNT-in 2.887 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -138.85, 172.45 APE9-dihe-na -51.51, 168.48 APE8-dihe-in -70.31, 126.41 APE8-rot-in 297.38 APE67-dihe-in -52.09, -31.08 -64.93, -41.24 APE12-dist-in 10.71 APE11-dist-out 6.48 APE10-dist-out 8.676 APE9-dist-in 3.964 Q207D None None XRAY 2.56 0.217 0.247 A 301 296 0 0 0 0 [[207, 497]] 1.0 4bgg TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
4BGGB 203 498 509.0 844:1000 Type1 Inactive DFGin 7.651 13.075 BLAminus -126.75, 170.2 64.89, 86.81 -96.93, 22.53 303.15, 172.06 -60.35, -29.64 in-out in 8.664 Saltbr-out 4.486 HRD-in -75.94, -57.13 76.77, 3.62 out-in-out SNCoio in-out ActLoopNT-in 2.897 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -139.3, 171.72 APE9-dihe-na -49.5, 168.53 APE8-dihe-in -70.36, 127.01 APE8-rot-in 296.26 APE67-dihe-in -54.49, -30.61 -64.06, -40.52 APE12-dist-in 10.752 APE11-dist-out 6.539 APE10-dist-out 8.705 APE9-dist-in 4.018 Q207D None None XRAY 2.56 0.217 0.247 B 301 293 3 0 0 0 [[207, 497]] 1.0 4bgg TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
4BGGC 204 497 509.0 844:1000 Type1 Inactive DFGin 7.671 13.139 BLAminus -121.52, 168.42 68.97, 89.32 -103.54, 23.49 302.06, 172.56 -58.81, -29.29 in-out in 8.713 Saltbr-out 4.661 HRD-in -76.71, -57.01 78.56, 1.53 out-in-out SNCoio in-out ActLoopNT-in 2.904 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -138.8, 173.51 APE9-dihe-na -53.86, 169.02 APE8-dihe-in -71.72, 126.65 APE8-rot-in 296.78 APE67-dihe-in -51.28, -31.99 -62.56, -42.69 APE12-dist-in 10.643 APE11-dist-out 6.63 APE10-dist-out 8.706 APE9-dist-in 3.97 Q207D None None XRAY 2.56 0.217 0.247 C 301 279 15 0 0 3 [[207, 497]] 1.0 4bgg TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
4BGGD 204 498 509.0 844:1000 Type1 Inactive DFGin 7.679 13.299 BLAminus -123.24, 170.49 65.5, 87.93 -101.92, 23.69 301.28, 172.56 -57.6, -28.63 in-out in 8.893 Saltbr-out 4.816 HRD-in -73.26, -58.16 80.03, 2.33 out-in-out SNCoio in-out ActLoopNT-in 2.881 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -139.49, 172.0 APE9-dihe-na -51.1, 169.58 APE8-dihe-in -71.78, 124.32 APE8-rot-in 297.27 APE67-dihe-in -52.31, -32.65 -62.65, -40.28 APE12-dist-in 10.744 APE11-dist-out 6.757 APE10-dist-out 8.675 APE9-dist-in 3.962 Q207D None None XRAY 2.56 0.217 0.247 D 301 286 9 0 0 0 [[207, 497]] 1.0 4bgg TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5OXGA 203 498 509.0 B4B:60501 Type1 Inactive DFGin 7.637 13.265 BLAminus -118.32, 174.58 68.98, 82.2 -98.18, 22.66 296.0, 151.09 -62.89, -28.13 in-out in 8.412 Saltbr-out 4.588 HRD-in -87.38, -54.01 77.94, -2.58 out-in-out SNCoio in-out ActLoopNT-in 2.899 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.81, 158.96 APE9-dihe-na -54.5, 161.85 APE8-dihe-in -60.3, 127.96 APE8-rot-in 304.93 APE67-dihe-in -54.5, -32.58 -65.84, -38.76 APE12-dist-in 10.536 APE11-dist-out 6.594 APE10-dist-out 9.125 APE9-dist-in 3.928 Q207D None None XRAY 2.13 0.207 0.232 A 301 293 3 0 0 0 [[207, 497]] 1.0 5oxg TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5OXGB 203 498 509.0 B4B:60501 Type1 Inactive DFGin 7.774 12.994 BLAminus -117.54, 172.65 67.77, 83.83 -97.74, 21.11 301.65, 151.21 -61.98, -29.72 in-out in 8.289 Saltbr-out 4.375 HRD-in -87.01, -54.36 76.79, -1.0 out-in-out SNCoio in-out ActLoopNT-in 2.894 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.05, 156.03 APE9-dihe-na -56.18, 161.08 APE8-dihe-in -61.29, 127.45 APE8-rot-in 305.02 APE67-dihe-in -55.81, -31.69 -67.18, -37.74 APE12-dist-in 10.593 APE11-dist-out 6.539 APE10-dist-out 9.168 APE9-dist-in 3.929 Q207D None None XRAY 2.13 0.207 0.232 B 301 296 0 0 0 0 [[207, 497]] 1.0 5oxg TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5OXGC 201 499 509.0 B4B:60501 Type1 Inactive DFGin 7.651 13.213 BLAminus -117.57, 174.46 68.52, 82.33 -97.58, 21.37 298.42, 152.27 -62.37, -27.96 in-out in 8.438 Saltbr-out 4.564 HRD-in -87.27, -54.15 76.99, -1.83 out-in-out SNCoio in-out ActLoopNT-in 2.901 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.01, 159.99 APE9-dihe-na -53.47, 160.0 APE8-dihe-in -61.0, 128.31 APE8-rot-in 304.03 APE67-dihe-in -52.77, -33.39 -66.51, -38.23 APE12-dist-in 10.623 APE11-dist-out 6.618 APE10-dist-out 9.051 APE9-dist-in 3.892 Q207D None None XRAY 2.13 0.207 0.232 C 301 299 0 0 0 0 [[207, 497]] 1.0 5oxg TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5OXGD 204 499 509.0 B4B:60501 Type1 Inactive DFGin 7.658 13.209 BLAminus -117.81, 173.57 68.25, 82.75 -97.79, 22.08 299.03, 151.44 -62.96, -27.82 in-out in 8.425 Saltbr-out 4.574 HRD-in -87.57, -53.89 77.97, -2.23 out-in-out SNCoio in-out ActLoopNT-in 2.901 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.11, 158.4 APE9-dihe-na -54.76, 160.73 APE8-dihe-in -60.1, 127.95 APE8-rot-in 304.17 APE67-dihe-in -54.05, -32.76 -65.2, -39.0 APE12-dist-in 10.537 APE11-dist-out 6.577 APE10-dist-out 9.122 APE9-dist-in 3.908 Q207D None None XRAY 2.13 0.207 0.232 D 301 293 3 0 0 0 [[207, 497]] 1.0 5oxg TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5OY6A 204 498 509.0 B4E:501 Type1 Inactive DFGin 8.291 13.252 BLAminus -124.42, 177.88 60.63, 75.45 -98.36, 24.99 289.66, 159.32 -68.92, -19.9 in-out in 8.639 Saltbr-out 4.821 HRD-in -67.77, -61.41 84.72, 1.07 out-in-out SNCoio in-out ActLoopNT-in 2.905 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -126.92, 159.12 APE9-dihe-na -54.75, 165.03 APE8-dihe-in -63.11, 127.19 APE8-rot-in 306.42 APE67-dihe-in -58.96, -26.1 -63.39, -37.66 APE12-dist-in 10.889 APE11-dist-out 7.509 APE10-dist-out 9.159 APE9-dist-in 4.058 Q207D None None XRAY 2.56 0.213 0.242 A 301 291 4 0 0 4 [[207, 497]] 1.0 5oy6 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5OY6B 203 498 509.0 B4E:501 Type1 Inactive DFGin 8.248 13.333 BLAminus -125.87, 178.71 61.82, 75.85 -101.33, 26.17 288.46, 162.63 -69.08, -20.03 in-out in 8.515 Saltbr-out 4.198 HRD-in -68.95, -63.27 85.74, 0.17 out-in-out SNCoio in-out ActLoopNT-in 2.958 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -127.6, 156.0 APE9-dihe-na -54.68, 165.41 APE8-dihe-in -64.35, 128.25 APE8-rot-in 306.22 APE67-dihe-in -62.96, -21.48 -62.63, -39.13 APE12-dist-in 10.681 APE11-dist-out 6.629 APE10-dist-out 9.201 APE9-dist-in 4.059 Q207D None None XRAY 2.56 0.213 0.242 B 301 292 4 0 0 4 [[207, 497]] 1.0 5oy6 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5OY6C 204 498 509.0 B4E:501 Type1 Inactive DFGin 7.783 13.737 BLAminus -125.03, 177.56 62.78, 78.08 -98.08, 25.7 291.29, 112.83 -67.62, -20.85 in-out in 8.707 Saltbr-out 4.666 HRD-in -66.74, -64.66 88.1, -0.91 out-in-out SNCoio in-out ActLoopNT-in 2.967 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -127.72, 150.97 APE9-dihe-na -57.32, 166.0 APE8-dihe-in -62.6, 125.98 APE8-rot-in 304.73 APE67-dihe-in -60.45, -23.22 -63.39, -39.0 APE12-dist-in 10.806 APE11-dist-out 7.01 APE10-dist-out 9.245 APE9-dist-in 4.096 Q207D None None XRAY 2.56 0.213 0.242 C 301 291 4 0 0 4 [[207, 497]] 1.0 5oy6 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5OY6D 204 499 509.0 B4E:501 Type1 Inactive DFGin 8.291 13.546 BLAminus -127.17, 177.39 63.16, 77.76 -100.16, 30.24 284.06, 110.55 -69.39, -22.09 in-none in 8.571 Saltbr-none 999.0 HRD-in -68.36, -61.68 86.2, 0.92 none-in-out SNCnio in-out ActLoopNT-in 2.896 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -128.01, 153.71 APE9-dihe-na -55.98, 170.12 APE8-dihe-in -61.71, 125.91 APE8-rot-in 305.4 APE67-dihe-in -60.01, -22.62 -62.93, -40.3 APE12-dist-in 10.633 APE11-dist-out 6.805 APE10-dist-out 9.067 APE9-dist-in 3.995 Q207D None None XRAY 2.56 0.213 0.242 D 301 292 4 0 0 4 [[207, 497]] 1.0 5oy6 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S77B 205 499 509.0 LU8:501 Type1 Inactive DFGin 7.031 13.453 BLAminus -124.57, 162.89 76.44, 87.16 -99.57, 19.41 300.08, 174.78 -68.76, -14.31 in-out in 8.853 Saltbr-out 4.653 HRD-in -77.29, -55.2 78.52, -0.63 out-in-out SNCoio in-out ActLoopNT-in 2.946 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.24, 166.6 APE9-dihe-na -61.81, 164.74 APE8-dihe-in -60.61, 127.64 APE8-rot-in 298.26 APE67-dihe-in -59.97, -28.12 -61.67, -40.13 APE12-dist-in 10.37 APE11-dist-out 6.209 APE10-dist-out 8.996 APE9-dist-in 3.824 Q207D None None XRAY 1.31 0.166 0.185 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s77 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S78B 208 499 509.0 LU8:501 Type1 Inactive DFGin 6.992 13.404 BLAminus -126.64, 164.14 74.77, 87.97 -101.18, 22.29 302.33, 177.25 -70.25, -15.52 in-out in 8.801 Saltbr-out 4.684 HRD-in -78.72, -53.62 78.73, -3.65 out-in-out SNCoio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.7, 165.64 APE9-dihe-na -61.72, 165.79 APE8-dihe-in -60.78, 129.07 APE8-rot-in 300.39 APE67-dihe-in -58.83, -27.2 -62.73, -40.71 APE12-dist-in 10.205 APE11-dist-out 6.245 APE10-dist-out 9.047 APE9-dist-in 3.86 Q207D None None XRAY 1.3 0.16 0.177 B 301 292 0 0 0 0 [[207, 497]] 1.0 5s78 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S79B 208 498 509.0 LU8:501 Type1 Inactive DFGin 6.949 13.409 BLAminus -122.03, 163.17 76.24, 92.19 -103.59, 21.82 301.57, 173.56 -69.99, -14.55 in-out in 8.607 Saltbr-out 3.776 HRD-in -77.29, -54.6 79.65, 0.11 out-in-out SNCoio in-out ActLoopNT-in 2.903 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -123.19, 173.51 APE9-dihe-na -67.77, 168.43 APE8-dihe-in -60.9, 124.36 APE8-rot-in 301.89 APE67-dihe-in -54.42, -27.95 -56.48, -46.08 APE12-dist-in 10.363 APE11-dist-out 6.644 APE10-dist-out 8.916 APE9-dist-in 3.749 Q207D None None XRAY 1.5 0.18 0.206 B 301 288 3 0 0 0 [[207, 497]] 1.0 5s79 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7GB 207 499 509.0 LU8:501 Type1 Inactive DFGin 6.641 13.495 BLAminus -119.72, 159.88 82.75, 87.21 -98.63, 18.92 305.17, 0.99 -67.48, -19.33 in-out in 9.017 Saltbr-out 4.958 HRD-in -77.01, -50.93 75.96, 1.34 out-in-none SNCoin in-none ActLoopNT-in 2.966 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -89.52, 148.19 APE9-dihe-na 117.39, 161.66 APE8-dihe-in -69.4, 128.02 APE8-rot-in 308.42 APE67-dihe-in -59.26, -33.51 -60.94, -38.65 APE12-dist-none 999.0 APE11-dist-in 11.662 APE10-dist-in 5.817 APE9-dist-in 3.942 Q207D None None XRAY 1.78 0.206 0.252 B 301 281 12 0 0 8 [[207, 497]] 1.0 5s7g TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7HB 205 499 509.0 LU8:501 Type1 Inactive DFGin 7.002 13.387 BLAminus -126.96, 163.26 76.81, 86.99 -100.87, 23.04 301.4, 176.52 -72.34, -14.12 in-out in 8.835 Saltbr-out 4.759 HRD-in -77.49, -53.08 77.02, -2.86 out-in-out SNCoio in-out ActLoopNT-in 2.943 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.19, 165.21 APE9-dihe-na -62.02, 164.93 APE8-dihe-in -59.21, 129.08 APE8-rot-in 298.47 APE67-dihe-in -58.12, -30.1 -64.15, -39.55 APE12-dist-in 10.313 APE11-dist-out 6.162 APE10-dist-out 9.011 APE9-dist-in 3.728 Q207D None None XRAY 1.3 0.158 0.18 B 301 293 2 0 0 0 [[207, 497]] 1.0 5s7h TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7JB 206 499 509.0 LU8:501 Type1 Inactive DFGin 6.972 13.39 BLAminus -125.59, 163.92 74.27, 89.45 -104.09, 21.89 302.89, 178.4 -70.85, -13.4 in-out in 8.791 Saltbr-out 4.723 HRD-in -74.57, -55.28 81.04, -2.31 out-in-out SNCoio in-out ActLoopNT-in 2.944 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.08, 165.49 APE9-dihe-na -60.51, 165.0 APE8-dihe-in -60.32, 128.5 APE8-rot-in 300.26 APE67-dihe-in -54.83, -31.02 -61.2, -43.09 APE12-dist-in 10.355 APE11-dist-out 6.167 APE10-dist-out 9.033 APE9-dist-in 3.806 Q207D None None XRAY 1.31 0.159 0.181 B 301 291 3 0 0 0 [[207, 497]] 1.0 5s7j TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7PB 208 499 509.0 LU8:501 Type1 Inactive DFGin 7.041 13.42 BLAminus -127.32, 160.61 79.2, 88.36 -101.38, 20.66 301.74, 174.56 -69.08, -14.59 in-out in 8.838 Saltbr-out 4.749 HRD-in -79.58, -51.94 76.5, -1.66 out-in-out SNCoio in-out ActLoopNT-in 2.946 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.23, 166.15 APE9-dihe-na -60.81, 164.72 APE8-dihe-in -59.48, 128.85 APE8-rot-in 300.38 APE67-dihe-in -62.62, -25.57 -64.98, -36.96 APE12-dist-in 10.458 APE11-dist-out 6.192 APE10-dist-out 8.971 APE9-dist-in 3.87 Q207D None None XRAY 1.31 0.158 0.176 B 301 289 3 0 0 0 [[207, 497]] 1.0 5s7p TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7WB 205 499 509.0 LU8:501 Type1 Inactive DFGin 7.03 13.401 BLAminus -127.76, 159.78 80.36, 85.76 -99.88, 21.09 305.52, 179.19 -65.9, -24.32 in-out in 8.94 Saltbr-out 4.819 HRD-in -77.42, -54.04 83.37, -7.62 out-in-out SNCoio in-out ActLoopNT-in 2.958 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -116.09, 164.43 APE9-dihe-na -60.72, 165.96 APE8-dihe-in -63.25, 128.46 APE8-rot-in 296.55 APE67-dihe-in -59.57, -28.14 -60.1, -41.66 APE12-dist-in 10.317 APE11-dist-out 6.247 APE10-dist-out 9.071 APE9-dist-in 3.811 Q207D None None XRAY 1.33 0.164 0.186 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s7w TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S83B 205 499 509.0 LU8:501 Type1 Inactive DFGin 7.033 13.478 BLAminus -124.19, 162.22 78.06, 86.57 -101.53, 19.96 300.51, 175.3 -64.11, -18.65 in-out in 8.89 Saltbr-out 4.771 HRD-in -75.73, -55.05 82.15, -4.6 out-in-out SNCoio in-out ActLoopNT-in 2.954 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.26, 164.39 APE9-dihe-na -61.1, 166.22 APE8-dihe-in -61.61, 128.13 APE8-rot-in 300.62 APE67-dihe-in -58.81, -29.24 -62.24, -41.18 APE12-dist-in 10.424 APE11-dist-out 6.285 APE10-dist-out 9.037 APE9-dist-in 3.856 Q207D None None XRAY 1.33 0.161 0.185 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s83 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S84B 206 499 509.0 LU8:501 Type1 Inactive DFGin 6.988 13.448 BLAminus -125.42, 163.93 74.98, 89.22 -103.06, 18.19 302.78, 175.41 -63.64, -17.13 in-out in 8.82 Saltbr-out 4.668 HRD-in -75.34, -54.28 80.29, -2.12 out-in-out SNCoio in-out ActLoopNT-in 2.916 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.41, 168.09 APE9-dihe-na -59.7, 163.97 APE8-dihe-in -58.67, 126.71 APE8-rot-in 301.06 APE67-dihe-in -57.69, -26.63 -61.25, -41.61 APE12-dist-in 10.345 APE11-dist-out 6.2 APE10-dist-out 9.014 APE9-dist-in 3.864 Q207D None None XRAY 1.35 0.166 0.191 B 301 291 3 0 0 0 [[207, 497]] 1.0 5s84 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S89B 205 499 509.0 LU8:501 Type1 Inactive DFGin 6.984 13.361 BLAminus -124.97, 163.75 76.76, 88.69 -102.06, 21.8 303.74, 177.29 -68.27, -19.19 in-out in 8.866 Saltbr-out 4.772 HRD-in -81.65, -52.32 78.48, -1.17 out-in-out SNCoio in-out ActLoopNT-in 2.922 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -117.77, 165.98 APE9-dihe-na -60.57, 167.11 APE8-dihe-in -63.21, 128.67 APE8-rot-in 299.1 APE67-dihe-in -57.43, -30.6 -61.18, -42.41 APE12-dist-in 10.276 APE11-dist-out 6.198 APE10-dist-out 8.992 APE9-dist-in 3.71 Q207D None None XRAY 1.3 0.156 0.174 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s89 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6GI6A 202 499 509.0 EZB:501 Type1 Inactive DFGin 7.422 13.322 BLAminus -127.88, 173.46 70.43, 82.55 -98.0, 26.87 288.66, 156.94 -67.23, -24.52 in-out in 8.499 Saltbr-out 4.338 HRD-in -79.97, -60.56 85.58, -0.98 out-in-out SNCoio in-out ActLoopNT-in 2.807 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -117.79, 141.92 APE9-dihe-na -55.69, 163.56 APE8-dihe-in -58.02, 123.22 APE8-rot-in 303.81 APE67-dihe-in -57.31, -31.72 -64.44, -36.13 APE12-dist-in 10.721 APE11-dist-out 6.48 APE10-dist-out 9.557 APE9-dist-in 4.129 Q207D None None XRAY 1.98 0.213 0.263 A 301 298 0 0 0 0 [[207, 497]] 1.0 6gi6 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6GINA 204 499 509.0 IR2:501 Type1 Inactive DFGin 7.879 13.312 BLAminus -121.27, 164.65 78.13, 83.84 -95.5, 20.22 297.8, 169.45 -69.16, -15.6 in-out in 8.878 Saltbr-out 4.872 HRD-in -75.63, -62.52 83.49, -5.41 out-in-out SNCoio in-out ActLoopNT-in 2.931 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.0, 167.37 APE9-dihe-na -63.42, 166.06 APE8-dihe-in -62.49, 126.47 APE8-rot-in 300.53 APE67-dihe-in -54.65, -29.35 -62.43, -43.34 APE12-dist-in 10.665 APE11-dist-out 6.722 APE10-dist-out 9.047 APE9-dist-in 3.915 Q207D None None XRAY 2.2 0.175 0.228 A 301 296 0 0 0 0 [[207, 497]] 1.0 6gin TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6GINB 204 499 509.0 IR2:501 Type1 Inactive DFGin 8.47 13.255 BLAminus -117.85, 169.5 76.39, 82.56 -95.36, 20.36 297.72, 170.4 -61.59, -30.68 in-out in 9.121 Saltbr-out 5.23 HRD-in -83.85, -57.15 83.89, -5.86 out-in-out SNCoio in-out ActLoopNT-in 2.924 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -128.3, 164.88 APE9-dihe-na -62.2, 169.83 APE8-dihe-in -64.53, 122.81 APE8-rot-in 301.07 APE67-dihe-in -53.52, -33.94 -60.13, -39.73 APE12-dist-in 10.724 APE11-dist-out 6.78 APE10-dist-out 8.739 APE9-dist-in 3.947 Q207D None None XRAY 2.2 0.175 0.228 B 301 296 0 0 0 0 [[207, 497]] 1.0 6gin TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6GIPA 204 499 509.0 EUN:501 Type1 Inactive DFGin 7.414 13.505 BLAminus -121.32, 176.37 70.61, 86.28 -96.75, 17.14 284.62, 145.48 -62.03, -23.64 in-out in 8.437 Saltbr-out 4.259 HRD-in -82.34, -53.01 79.89, 0.83 out-in-out SNCoio in-out ActLoopNT-in 2.829 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -112.13, 155.12 APE9-dihe-na -62.81, 175.41 APE8-dihe-in -72.99, 121.09 APE8-rot-in 307.8 APE67-dihe-in -54.26, -31.45 -59.06, -38.64 APE12-dist-in 10.533 APE11-dist-out 6.593 APE10-dist-out 9.307 APE9-dist-in 4.177 Q207D None None XRAY 2.17 0.195 0.239 A 301 296 0 0 0 0 [[207, 497]] 1.0 6gip TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6SRHA 201 499 509.0 LU8:501 Type1 Inactive DFGin 8.337 13.442 BLAminus -122.57, 162.03 75.26, 88.46 -99.42, 24.23 300.0, 175.86 -68.83, -17.25 in-out in 9.271 Saltbr-out 6.184 HRD-in -78.85, -52.97 79.59, -0.55 out-in-out SNCoio in-out ActLoopNT-in 2.952 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.6, 171.91 APE9-dihe-na -65.69, 166.15 APE8-dihe-in -64.37, 126.3 APE8-rot-in 301.19 APE67-dihe-in -57.05, -29.89 -63.28, -37.95 APE12-dist-in 10.996 APE11-dist-out 6.191 APE10-dist-out 8.89 APE9-dist-in 3.672 Q207D None None XRAY 1.25 0.134 0.16 A 301 288 11 0 0 11 [[207, 497]] 1.0 6srh TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6SZMB 205 499 509.0 M2Z:501 Type1 Inactive DFGin 6.889 13.38 BLAminus -130.45, 165.06 76.0, 85.65 -99.23, 20.14 303.49, 173.6 -70.24, -14.21 in-out in 8.854 Saltbr-out 4.716 HRD-in -80.29, -50.69 76.82, 0.43 out-in-out SNCoio in-out ActLoopNT-in 2.943 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.93, 162.59 APE9-dihe-na -62.54, 170.01 APE8-dihe-in -65.85, 128.73 APE8-rot-in 300.13 APE67-dihe-in -58.84, -26.54 -57.25, -44.85 APE12-dist-in 10.309 APE11-dist-out 6.286 APE10-dist-out 9.077 APE9-dist-in 3.776 None None None XRAY 1.42 0.154 0.188 B 301 295 0 0 0 0 [[207, 497]] 1.0 6szm TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6T6DD 203 498 509.0 MM8:501 Type1 Inactive DFGin 7.617 12.599 BLAminus -126.5, 165.83 73.29, 84.55 -98.79, 17.26 305.85, 171.23 -61.04, -35.17 in-out in 8.139 Saltbr-out 5.221 HRD-in -66.75, -60.44 83.42, 7.04 out-in-none SNCoin in-none ActLoopNT-in 2.729 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -100.75, 149.74 APE9-dihe-na 135.34, 156.1 APE8-dihe-in -58.61, 125.21 APE8-rot-in 305.55 APE67-dihe-in -57.51, -24.77 -65.16, -37.29 APE12-dist-none 999.0 APE11-dist-in 10.268 APE10-dist-in 6.797 APE9-dist-in 4.182 Q207D None None XRAY 2.56 0.224 0.272 D 301 285 11 0 0 11 [[207, 497]] 1.0 6t6d TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6T8NA 203 498 509.0 MVE:604 Type1 Inactive DFGin 8.239 13.54 BLAminus -117.22, 176.03 72.91, 63.91 -91.39, 23.17 287.75, 168.53 -67.92, -18.8 in-out in 8.933 Saltbr-out 4.707 HRD-in -84.95, -51.56 81.75, -3.33 out-in-out SNCoio in-out ActLoopNT-in 2.815 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.51, 167.12 APE9-dihe-na -61.87, 158.02 APE8-dihe-in -61.33, 127.98 APE8-rot-in 306.21 APE67-dihe-in -60.03, -27.55 -64.05, -36.62 APE12-dist-in 10.612 APE11-dist-out 6.629 APE10-dist-out 9.087 APE9-dist-in 4.125 Q207D None None XRAY 1.77 0.205 0.237 A 301 293 3 0 0 0 [[207, 497]] 1.0 6t8n TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6T8NB 203 499 509.0 MVE:606 Type1 Inactive DFGin 8.566 13.447 BLAminus -115.44, -178.9 71.98, 70.18 -99.66, 24.02 289.42, 166.62 -70.33, -17.84 in-out in 9.075 Saltbr-out 4.916 HRD-in -81.57, -50.67 76.26, -0.18 out-in-out SNCoio in-out ActLoopNT-in 2.9 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.64, 165.39 APE9-dihe-na -58.57, 157.21 APE8-dihe-in -58.07, 130.83 APE8-rot-in 301.01 APE67-dihe-in -55.44, -32.97 -60.5, -39.92 APE12-dist-in 10.528 APE11-dist-out 6.381 APE10-dist-out 9.178 APE9-dist-in 4.038 Q207D None None XRAY 1.77 0.205 0.237 B 301 293 4 0 0 0 [[207, 497]] 1.0 6t8n TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6TN8A 204 499 509.0 5U6:505 Type1 Inactive DFGin 7.003 13.652 BLAminus -130.26, 163.23 78.2, 92.28 -100.4, 19.39 297.25, 1.05 -69.42, -14.3 in-out in 8.615 Saltbr-out 5.966 HRD-in -83.31, -56.24 82.45, -1.3 out-in-out SNCoio in-out ActLoopNT-in 2.875 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -117.0, 166.36 APE9-dihe-na -66.52, 164.84 APE8-dihe-in -59.49, 124.33 APE8-rot-in 302.89 APE67-dihe-in -55.89, -27.94 -60.94, -41.66 APE12-dist-in 10.406 APE11-dist-out 6.468 APE10-dist-out 9.121 APE9-dist-in 3.731 None None None XRAY 1.63 0.23 0.262 A 301 296 0 0 0 0 [[207, 497]] 1.0 6tn8 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6Z36B 204 498 509.0 Q5Z:603 Type1 Inactive DFGin 6.88 13.527 BLAminus -126.16, 165.21 76.57, 84.99 -100.04, 20.28 298.99, 173.38 -68.85, -18.38 in-out in 8.893 Saltbr-out 4.65 HRD-in -80.23, -52.08 77.68, -0.84 out-in-out SNCoio in-out ActLoopNT-in 2.974 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.07, 163.14 APE9-dihe-na -61.96, 174.49 APE8-dihe-in -69.93, 128.14 APE8-rot-in 297.68 APE67-dihe-in -61.25, -26.77 -56.9, -42.94 APE12-dist-in 10.414 APE11-dist-out 6.324 APE10-dist-out 9.049 APE9-dist-in 3.799 Q207D None None XRAY 1.37 0.151 0.191 B 301 293 2 0 0 0 [[207, 497]] 1.0 6z36 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
7A21A 203 498 509.0 QWQ:501 Type1 Inactive DFGin 7.382 13.169 BLAminus -127.76, 158.55 80.05, 87.13 -96.73, 14.66 294.42, 153.21 -62.06, -21.0 in-out in 8.323 Saltbr-out 4.348 HRD-in -78.22, -57.26 78.46, 2.93 out-in-out SNCoio in-out ActLoopNT-in 2.806 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -127.16, 161.76 APE9-dihe-na -62.55, 162.64 APE8-dihe-in -58.51, 125.54 APE8-rot-in 301.03 APE67-dihe-in -51.19, -25.85 -61.35, -46.92 APE12-dist-in 10.598 APE11-dist-out 6.485 APE10-dist-out 9.161 APE9-dist-in 3.838 Q207D None None XRAY 2.14 0.21 0.256 A 301 296 0 0 0 0 [[207, 497]] 1.0 7a21 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
7A21B 203 498 509.0 QWQ:501 Type1 Inactive DFGin 8.551 13.425 BLAminus -134.98, 161.81 74.98, 86.69 -95.85, 23.59 296.34, 175.33 -57.61, -25.52 in-out in 8.645 Saltbr-out 5.44 HRD-in -82.57, -62.71 85.35, -0.84 out-in-out SNCoio in-out ActLoopNT-in 2.721 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -126.21, 168.9 APE9-dihe-na -61.22, 161.93 APE8-dihe-in -55.41, 123.95 APE8-rot-in 309.75 APE67-dihe-in -53.39, -33.78 -63.89, -37.45 APE12-dist-in 10.776 APE11-dist-out 6.54 APE10-dist-out 9.09 APE9-dist-in 3.9 Q207D None None XRAY 2.14 0.21 0.256 B 301 296 0 0 0 0 [[207, 497]] 1.0 7a21 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
7NNSB 204 499 509.0 C87:507 Type1 Inactive DFGin 8.06 12.82 BLAminus -133.17, -176.16 65.22, 65.05 -96.55, 15.24 297.87, 150.85 -66.46, -15.55 in-out in 8.801 Saltbr-out 5.094 HRD-in -81.45, -57.24 85.72, -1.07 out-in-out SNCoio in-out ActLoopNT-in 2.913 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -113.15, 156.87 APE9-dihe-na -64.22, 158.78 APE8-dihe-in -55.79, 124.56 APE8-rot-in 304.92 APE67-dihe-in -55.54, -37.05 -65.15, -36.45 APE12-dist-in 10.499 APE11-dist-out 6.32 APE10-dist-out 9.652 APE9-dist-in 4.531 Q207D None None XRAY 2.14 0.23 0.269 B 301 296 0 0 0 0 [[207, 497]] 1.0 7nns TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
8C7WA 202 499 509.0 U0C:501 Type1 Inactive DFGin 7.204 13.051 BLAminus -128.22, 168.64 69.43, 93.94 -103.93, 18.54 295.47, 153.77 -65.01, -20.19 in-out in 8.678 Saltbr-out 4.471 HRD-in -82.72, -56.02 79.41, 2.44 out-in-out SNCoio in-out ActLoopNT-in 2.965 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -108.26, 150.44 APE9-dihe-na -62.04, 172.48 APE8-dihe-in -69.23, 126.84 APE8-rot-in 300.76 APE67-dihe-in -67.12, -32.26 -66.04, -29.76 APE12-dist-in 10.583 APE11-dist-out 6.189 APE10-dist-out 9.621 APE9-dist-in 4.225 Q207D None None XRAY 2.26 0.209 0.239 A 301 298 0 0 0 0 [[207, 497]] 1.0 8c7w TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
8C7ZA 204 498 509.0 TZX:502 Type1 Inactive DFGin 7.001 13.539 BLAminus -129.04, 178.53 61.89, 92.69 -101.8, 21.5 274.24, 128.16 -70.35, -21.45 in-out in 8.56 Saltbr-out 4.534 HRD-in -77.94, -53.22 74.05, 9.22 out-in-out SNCoio in-out ActLoopNT-in 2.836 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -104.81, 151.04 APE9-dihe-na -67.81, 170.33 APE8-dihe-in -65.57, 126.09 APE8-rot-in 307.68 APE67-dihe-in -60.34, -30.84 -67.16, -35.46 APE12-dist-in 10.599 APE11-dist-out 6.39 APE10-dist-out 9.707 APE9-dist-in 4.192 Q207D None None XRAY 2.23 0.216 0.261 A 301 295 0 0 0 0 [[207, 497]] 1.0 8c7z TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
8R7GA 205 499 509.0 YEE:501 Type1 Inactive DFGin 7.873 13.114 BLAminus -125.34, 176.57 61.75, 79.56 -92.18, 25.14 304.23, 156.54 -66.96, -22.65 in-out in 8.25 Saltbr-out 4.604 HRD-in -86.83, -53.56 76.37, 0.62 out-in-out SNCoio in-out ActLoopNT-in 3.003 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -99.53, 168.92 APE9-dihe-na -60.18, 166.2 APE8-dihe-in -61.99, 126.25 APE8-rot-in 300.64 APE67-dihe-in -53.95, -28.13 -65.83, -38.49 APE12-dist-in 10.96 APE11-dist-out 7.324 APE10-dist-out 9.123 APE9-dist-in 3.874 Q207D None None XRAY 2.09 0.228 0.253 A 301 293 2 0 0 0 [[207, 497]] 1.0 8r7g TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
8R7GB 205 498 509.0 YEE:501 Type1 Inactive DFGin 7.702 12.84 BLAminus -132.3, 173.86 64.56, 82.91 -96.15, 22.56 312.11, 149.54 -62.02, -22.37 in-out in 8.118 Saltbr-out 3.902 HRD-in -80.65, -58.3 79.92, 2.55 out-in-out SNCoio in-out ActLoopNT-in 2.903 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -108.9, 170.94 APE9-dihe-na -68.07, 167.85 APE8-dihe-in -62.36, 121.37 APE8-rot-in 303.04 APE67-dihe-in -62.81, -26.45 -65.67, -29.35 APE12-dist-in 10.843 APE11-dist-out 7.472 APE10-dist-out 9.043 APE9-dist-in 4.083 Q207D None None XRAY 2.09 0.228 0.253 B 301 293 1 0 0 0 [[207, 497]] 1.0 8r7g TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
8R7GD 204 498 509.0 YEE:501 Type1 Inactive DFGin 7.656 12.786 BLAminus -130.9, 171.35 64.69, 82.55 -97.53, 20.28 313.61, 165.44 -62.7, -21.28 in-none in 8.092 Saltbr-none 999.0 HRD-in -80.62, -57.63 79.17, 3.62 none-in-out SNCnio in-out ActLoopNT-in 2.934 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -131.29, 164.75 APE9-dihe-na -65.63, 171.5 APE8-dihe-in -60.25, 124.44 APE8-rot-in 310.83 APE67-dihe-in -65.19, -26.25 -64.07, -29.53 APE12-dist-in 10.404 APE11-dist-out 7.022 APE10-dist-out 8.812 APE9-dist-in 3.875 Q207D None None XRAY 2.09 0.228 0.253 D 301 291 4 0 0 4 [[207, 497]] 1.0 8r7g TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
9D8FA 193 499 509.0 A1A3C:608 Type1 Inactive DFGin 7.319 13.378 BLAminus -128.66, 164.64 72.87, 86.41 -100.74, 20.77 306.08, 179.38 -70.71, -15.71 in-out in 9.123 Saltbr-out 5.266 HRD-in -77.6, -50.3 78.68, -1.87 out-in-in SNCoii in-in ActLoopNT-in 2.998 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -95.63, -21.01 APE9-dihe-na -90.14, -153.44 APE8-dihe-in -88.84, 122.95 APE8-rot-in 297.07 APE67-dihe-in -54.58, -31.52 -56.69, -42.93 APE12-dist-in 11.791 APE11-dist-in 12.192 APE10-dist-in 6.259 APE9-dist-in 3.789 None None None XRAY 1.86 0.187 0.223 A 317 307 0 0 0 0 [[207, 497]] 1.0 9d8f TKL_ACVR1_HUMAN TKL 2.2e-85 292.3 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
9D8FB 200 499 509.0 A1A3C:606 Type1 Inactive DFGin 7.398 13.213 BLAminus -125.37, 164.88 73.85, 83.9 -100.55, 21.31 302.03, 2.88 -74.3, -19.34 in-out in 8.893 Saltbr-out 5.062 HRD-in -75.68, -49.36 71.42, 0.82 out-in-in SNCoii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -90.91, 161.07 APE9-dihe-na 99.85, -170.3 APE8-dihe-in -94.7, 121.59 APE8-rot-in 300.47 APE67-dihe-in -54.39, -30.52 -51.8, -45.77 APE12-dist-in 11.878 APE11-dist-in 12.499 APE10-dist-in 6.442 APE9-dist-in 3.891 None None None XRAY 1.86 0.187 0.223 B 317 300 0 0 0 0 [[207, 497]] 1.0 9d8f TKL_ACVR1_HUMAN TKL 2.2e-85 292.3 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
8UWRA 203 499 509.0 XQX:1007 Type1 Inactive DFGin 7.663 12.998 BLAminus -113.6, -176.93 71.58, 63.25 -92.75, 22.04 315.88, 3.12 -61.86, -28.81 in-out in 9.066 Saltbr-out 4.698 HRD-in -80.27, -50.42 75.31, 12.27 out-in-out SNCoio in-out ActLoopNT-in 2.788 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -115.11, 172.35 APE9-dihe-na -50.98, 178.62 APE8-dihe-in -78.55, 133.54 APE8-rot-in 298.31 APE67-dihe-in -49.27, -34.62 -72.69, -44.99 APE12-dist-in 10.693 APE11-dist-out 6.773 APE10-dist-out 8.709 APE9-dist-in 3.818 Q207D None None XRAY 2.04 0.214 0.281 A 323 297 0 0 0 0 [[207, 497]] 1.0 8uwr TKL_ACVR1_HUMAN TKL 2.5e-85 292.2 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
3H9RA 172 499 509.0 TAK:1 Type1 Inactive DFGin 7.518 13.014 BLAminus -122.25, 172.9 70.66, 76.36 -93.47, 23.87 309.45, 171.73 -63.2, -18.75 in-out in 8.451 Saltbr-out 4.425 HRD-in -86.19, -50.58 71.93, 4.62 out-in-out SNCoio in-out ActLoopNT-in 2.955 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -141.78, 171.85 APE9-dihe-na -47.59, 161.63 APE8-dihe-in -64.93, 129.41 APE8-rot-in 303.28 APE67-dihe-in -52.25, -29.45 -62.04, -44.48 APE12-dist-none 999.0 APE11-dist-out 6.953 APE10-dist-out 8.669 APE9-dist-in 3.713 None None None XRAY 2.35 0.187 0.256 A 330 312 16 0 0 13 [[207, 497]] 1.0 3h9r TKL_ACVR1_HUMAN TKL 2.6e-85 292.1 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
4C02A 178 499 509.0 TAK:1507 Type1 Inactive DFGin 7.528 12.943 BLAminus -123.21, 176.23 69.71, 70.69 -93.29, 15.04 304.56, 179.92 -66.52, -15.92 in-out in 8.69 Saltbr-out 4.668 HRD-in -78.82, -50.72 79.56, 2.7 out-in-in SNCoii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -100.38, -27.16 APE9-dihe-na -78.85, -155.95 APE8-dihe-in -85.96, 128.83 APE8-rot-in 303.97 APE67-dihe-in -57.18, -27.24 -62.7, -42.91 APE12-dist-in 12.293 APE11-dist-in 12.134 APE10-dist-in 6.189 APE9-dist-in 3.597 None None None XRAY 2.17 0.178 0.198 A 330 313 5 0 0 3 [[207, 497]] 1.0 4c02 TKL_ACVR1_HUMAN TKL 2.6e-85 292.1 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6I1SA 172 499 509.0 E26:60501 Type1 Inactive DFGin 7.265 13.104 BLAminus -124.43, 167.68 73.9, 86.48 -100.59, 21.04 307.07, 1.66 -69.49, -17.73 in-out in 8.592 Saltbr-out 4.99 HRD-in -80.83, -53.14 79.1, -3.5 out-in-out SNCoio in-out ActLoopNT-in 2.927 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.74, 165.26 APE9-dihe-na -62.48, 165.28 APE8-dihe-in -62.22, 125.14 APE8-rot-in 300.67 APE67-dihe-in -57.23, -27.57 -60.91, -40.83 APE12-dist-in 10.361 APE11-dist-out 6.208 APE10-dist-out 9.062 APE9-dist-in 3.799 None None None XRAY 1.52 0.177 0.193 A 330 320 3 0 0 0 [[207, 497]] 1.0 6i1s TKL_ACVR1_HUMAN TKL 2.6e-85 292.1 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
9D8EA 193 499 509.0 A1A29:703 Type1 Inactive DFGin 7.382 13.329 BLAminus -126.65, 164.15 70.79, 84.87 -98.58, 18.71 305.74, 179.57 -69.37, -18.79 in-out in 9.13 Saltbr-out 4.978 HRD-in -75.96, -48.11 74.25, -2.76 out-in-in SNCoii in-in ActLoopNT-in 2.872 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -95.78, -21.58 APE9-dihe-na -90.92, -141.42 APE8-dihe-in -99.59, 122.26 APE8-rot-in 299.69 APE67-dihe-in -58.11, -27.93 -57.36, -41.17 APE12-dist-in 11.729 APE11-dist-in 12.251 APE10-dist-in 6.291 APE9-dist-in 3.835 None None None XRAY 1.72 0.192 0.215 A 330 307 0 0 0 0 [[207, 497]] 1.0 9d8e TKL_ACVR1_HUMAN TKL 2.6e-85 292.1 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
9D8EB 193 498 509.0 A1A29:501 Type1 Inactive DFGin 7.488 13.211 BLAminus -125.78, 165.64 71.99, 85.49 -102.71, 20.66 303.4, 179.67 -73.83, -20.49 in-out in 8.922 Saltbr-out 4.969 HRD-in -75.14, -48.46 72.82, -0.2 out-in-in SNCoii in-in ActLoopNT-in 2.808 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -98.27, -24.55 APE9-dihe-na -80.6, -148.51 APE8-dihe-in -94.26, 124.81 APE8-rot-in 298.35 APE67-dihe-in -52.79, -30.62 -58.26, -44.61 APE12-dist-in 12.424 APE11-dist-in 12.379 APE10-dist-in 6.408 APE9-dist-in 3.823 None None None XRAY 1.72 0.192 0.215 B 330 306 0 0 0 0 [[207, 497]] 1.0 9d8e TKL_ACVR1_HUMAN TKL 2.6e-85 292.1 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
9RDAA 172 498 509.0 A1JFB:60501 Type1 Inactive DFGin 7.149 13.354 BLAminus -120.05, 170.69 71.22, 87.8 -102.97, 21.72 293.91, 179.06 -69.95, -15.99 in-in in 8.666 Saltbr-in 2.713 HRD-in -84.22, -53.25 81.1, -4.12 in-in-out SNCiio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.83, 166.35 APE9-dihe-na -61.6, 166.43 APE8-dihe-in -66.45, 126.88 APE8-rot-in 299.97 APE67-dihe-in -55.55, -28.43 -54.54, -47.13 APE12-dist-in 10.371 APE11-dist-out 6.199 APE10-dist-out 9.069 APE9-dist-in 3.796 None None None XRAY 1.748 0.195 0.224 A 330 318 4 0 0 0 [[207, 497]] 1.0 9rda TKL_ACVR1_HUMAN TKL 2.6e-85 292.1 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
9D8ZA 203 499 509.0 A1A3D:600 Type1 Inactive DFGin 7.3 13.256 BLAminus -126.41, 165.94 76.26, 83.89 -99.24, 19.19 298.52, 8.39 -72.77, -19.83 in-out in 8.907 Saltbr-out 5.116 HRD-in -79.25, -49.91 75.06, -1.44 out-in-in SNCoii in-in ActLoopNT-in 2.873 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -100.72, -28.37 APE9-dihe-na -75.53, -154.22 APE8-dihe-in -89.92, 122.57 APE8-rot-in 298.44 APE67-dihe-in -58.34, -27.86 -55.41, -41.19 APE12-dist-in 11.918 APE11-dist-in 12.399 APE10-dist-in 6.418 APE9-dist-in 3.791 None None None XRAY 1.85 0.19 0.223 A 332 297 0 0 0 0 [[207, 497]] 1.0 9d8z TKL_ACVR1_HUMAN TKL 2.7e-85 292.1 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
9D8ZB 193 499 509.0 A1A3D:600 Type1 Inactive DFGin 7.222 13.356 BLAminus -127.23, 166.36 73.43, 87.62 -100.88, 19.83 305.62, 0.23 -71.22, -15.61 in-out in 9.127 Saltbr-out 5.28 HRD-in -78.78, -47.38 76.09, -4.59 out-in-in SNCoii in-in ActLoopNT-in 3.015 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -91.25, -21.49 APE9-dihe-na -85.77, -158.58 APE8-dihe-in -85.31, 123.28 APE8-rot-in 302.29 APE67-dihe-in -60.96, -29.24 -58.86, -37.28 APE12-dist-in 11.753 APE11-dist-in 12.19 APE10-dist-in 6.198 APE9-dist-in 3.795 None None None XRAY 1.85 0.19 0.223 B 332 307 0 0 0 0 [[207, 497]] 1.0 9d8z TKL_ACVR1_HUMAN TKL 2.7e-85 292.1 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6UNSA 204 496 509.0 LDN:501 Type1 Inactive DFGin 7.224 12.856 BLAminus -117.56, 173.67 72.35, 88.75 -102.95, 22.4 297.93, 174.62 -66.2, -23.82 in-in in 8.105 Saltbr-in 2.98 HRD-in -81.6, -59.03 82.63, -0.45 in-in-out SNCiio in-out ActLoopNT-in 2.813 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -93.62, 142.8 APE9-dihe-na -63.9, 171.12 APE8-dihe-in -66.39, 123.82 APE8-rot-in 304.97 APE67-dihe-in -58.01, -31.11 -66.21, -35.39 APE12-dist-in 10.492 APE11-dist-out 6.558 APE10-dist-out 10.005 APE9-dist-in 4.508 K492A,K493A None None XRAY 2.3 0.215 0.262 A 330 288 6 0 0 0 [[207, 497]] 1.0 6uns TKL_ACVR1_HUMAN TKL 7.3e-85 290.8 2 266 265 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6UNSB 204 496 509.0 LDN:501 Type1 Inactive DFGin 7.709 12.736 BLAminus -118.56, 173.66 72.39, 85.71 -105.41, 24.1 306.63, 13.91 -67.87, -22.75 in-out in 8.235 Saltbr-out 3.878 HRD-in -80.19, -57.75 81.06, 0.8 out-in-out SNCoio in-out ActLoopNT-in 2.772 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -97.69, 138.7 APE9-dihe-na -64.83, 170.36 APE8-dihe-in -65.69, 123.25 APE8-rot-in 313.39 APE67-dihe-in -58.4, -31.45 -67.8, -32.39 APE12-dist-in 10.479 APE11-dist-out 6.408 APE10-dist-out 9.87 APE9-dist-in 4.562 K492A,K493A None None XRAY 2.3 0.215 0.262 B 330 290 4 0 0 0 [[207, 497]] 1.0 6uns TKL_ACVR1_HUMAN TKL 7.3e-85 290.8 2 266 265 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6EIXA 192 503 509.0 A3F:601 Type1 Inactive DFGin 7.305 13.382 BLAminus -122.31, 163.89 74.01, 85.68 -98.53, 23.31 310.02, 174.96 -66.89, -23.04 in-out in 9.083 Saltbr-out 5.16 HRD-in -81.6, -53.66 78.97, -2.54 out-in-out SNCoio in-out ActLoopNT-in 3.023 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -113.45, 165.41 APE9-dihe-na -59.94, 163.8 APE8-dihe-in -59.76, 126.51 APE8-rot-in 307.55 APE67-dihe-in -58.05, -30.26 -58.58, -41.78 APE12-dist-in 10.589 APE11-dist-out 6.415 APE10-dist-out 9.311 APE9-dist-in 3.871 Q207E None None XRAY 2.3 0.191 0.249 A 340 312 0 0 0 0 [[207, 497]] 1.0 6eix TKL_ACVR1_HUMAN TKL 2.9e-85 292.0 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7BB 205 499 509.0 LU8:501,XH7:506 Type1,Allosteric Inactive DFGin 7.021 13.362 BLAminus -121.46, 161.83 78.44, 88.34 -102.47, 19.49 301.42, 173.88 -65.45, -20.59 in-out in 8.79 Saltbr-out 4.685 HRD-in -74.99, -55.16 78.67, -0.58 out-in-out SNCoio in-out ActLoopNT-in 2.913 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.52, 156.89 APE9-dihe-na -51.95, 170.55 APE8-dihe-in -69.31, 128.28 APE8-rot-in 299.94 APE67-dihe-in -63.25, -25.99 -60.99, -39.27 APE12-dist-in 10.404 APE11-dist-out 6.393 APE10-dist-out 9.095 APE9-dist-in 3.807 Q207D None None XRAY 1.32 0.169 0.195 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s7b TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7CB 205 499 509.0 LU8:501,T5Y:505 Type1,Allosteric Inactive DFGin 7.062 13.389 BLAminus -126.3, 161.98 79.71, 89.61 -103.06, 23.5 302.55, 173.63 -67.99, -21.1 in-out in 8.854 Saltbr-out 4.758 HRD-in -77.43, -53.45 76.82, -0.13 out-in-out SNCoio in-out ActLoopNT-in 2.913 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.01, 166.06 APE9-dihe-na -60.91, 165.47 APE8-dihe-in -62.27, 130.39 APE8-rot-in 299.14 APE67-dihe-in -63.71, -26.19 -64.69, -37.05 APE12-dist-in 10.364 APE11-dist-out 6.238 APE10-dist-out 8.994 APE9-dist-in 3.938 Q207D None None XRAY 1.31 0.161 0.179 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s7c TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7DB 205 499 509.0 LU8:501,XHD:505 Type1,Allosteric Inactive DFGin 7.0 13.349 BLAminus -123.42, 163.32 74.65, 90.04 -104.07, 23.56 302.54, 177.54 -72.51, -12.63 in-out in 8.759 Saltbr-out 4.702 HRD-in -77.61, -53.61 80.79, -1.13 out-in-out SNCoio in-out ActLoopNT-in 2.969 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.29, 164.81 APE9-dihe-na -57.91, 162.72 APE8-dihe-in -60.44, 129.2 APE8-rot-in 299.64 APE67-dihe-in -59.07, -29.49 -62.4, -40.3 APE12-dist-in 10.358 APE11-dist-out 6.219 APE10-dist-out 9.026 APE9-dist-in 3.786 Q207D None None XRAY 1.31 0.165 0.185 B 301 295 0 0 0 0 [[207, 497]] 1.0 5s7d TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7EB 205 499 509.0 LU8:501,XEA:505 Type1,Allosteric Inactive DFGin 7.001 13.456 BLAminus -126.91, 163.64 73.07, 91.25 -103.42, 21.63 301.95, 174.37 -67.85, -18.9 in-out in 8.813 Saltbr-out 4.722 HRD-in -77.73, -53.3 79.65, -3.06 out-in-out SNCoio in-out ActLoopNT-in 2.929 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -117.66, 166.82 APE9-dihe-na -61.55, 164.95 APE8-dihe-in -59.98, 129.55 APE8-rot-in 299.19 APE67-dihe-in -58.01, -29.13 -63.05, -41.4 APE12-dist-in 10.258 APE11-dist-out 6.215 APE10-dist-out 9.008 APE9-dist-in 3.801 Q207D None None XRAY 1.32 0.168 0.189 B 301 293 2 0 0 0 [[207, 497]] 1.0 5s7e TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7KB 205 499 509.0 LU8:501,XEJ:504 Type1,Allosteric Inactive DFGin 6.981 13.27 BLAminus -124.3, 164.86 75.9, 87.47 -102.78, 21.12 305.49, 0.35 -65.97, -18.91 in-out in 8.834 Saltbr-out 4.647 HRD-in -79.74, -53.13 79.6, -2.25 out-in-out SNCoio in-out ActLoopNT-in 2.859 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.28, 163.22 APE9-dihe-na -60.14, 169.9 APE8-dihe-in -64.39, 127.18 APE8-rot-in 298.46 APE67-dihe-in -57.76, -29.28 -59.11, -42.6 APE12-dist-in 10.421 APE11-dist-out 6.301 APE10-dist-out 8.974 APE9-dist-in 3.677 None None None XRAY 1.31 0.162 0.188 B 301 293 2 0 0 0 [[207, 497]] 1.0 5s7k TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7MB 208 499 509.0 LU8:501,HVK:505 Type1,Allosteric Inactive DFGin 7.009 13.321 BLAminus -124.89, 160.91 76.23, 87.23 -100.03, 22.28 300.52, 174.89 -68.18, -14.07 in-out in 8.451 Saltbr-out 4.202 HRD-in -76.72, -54.96 80.02, -2.85 out-in-out SNCoio in-out ActLoopNT-in 2.924 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.58, 168.17 APE9-dihe-na -62.95, 162.95 APE8-dihe-in -58.04, 127.45 APE8-rot-in 298.56 APE67-dihe-in -59.18, -25.23 -62.3, -40.69 APE12-dist-in 10.37 APE11-dist-out 6.21 APE10-dist-out 8.938 APE9-dist-in 3.814 Q207D None None XRAY 1.32 0.171 0.195 B 301 290 2 0 0 0 [[207, 497]] 1.0 5s7m TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7NB 207 499 509.0 LU8:501,2AI:505 Type1,Allosteric Inactive DFGin 7.005 13.42 BLAminus -126.13, 161.61 77.78, 88.49 -101.78, 20.71 303.39, 175.45 -67.06, -19.53 in-out in 8.86 Saltbr-out 4.716 HRD-in -78.53, -54.27 81.6, -6.08 out-in-out SNCoio in-out ActLoopNT-in 2.957 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.2, 164.62 APE9-dihe-na -57.6, 161.75 APE8-dihe-in -58.85, 126.75 APE8-rot-in 300.18 APE67-dihe-in -61.19, -26.66 -59.93, -40.36 APE12-dist-in 10.27 APE11-dist-out 6.151 APE10-dist-out 9.007 APE9-dist-in 3.756 Q207D None None XRAY 1.3 0.163 0.186 B 301 290 3 0 0 0 [[207, 497]] 1.0 5s7n TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7SB 205 499 509.0 LU8:501,09V:505 Type1,Allosteric Inactive DFGin 6.987 13.406 BLAminus -127.22, 162.49 75.55, 89.77 -103.58, 21.52 302.17, 178.46 -71.16, -15.05 in-out in 8.879 Saltbr-out 4.766 HRD-in -78.6, -54.23 80.1, -1.5 out-in-out SNCoio in-out ActLoopNT-in 2.925 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.31, 165.17 APE9-dihe-na -61.08, 163.96 APE8-dihe-in -59.96, 128.29 APE8-rot-in 298.36 APE67-dihe-in -59.32, -26.33 -61.06, -42.91 APE12-dist-in 10.26 APE11-dist-out 6.189 APE10-dist-out 9.019 APE9-dist-in 3.778 Q207D None None XRAY 1.3 0.153 0.171 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s7s TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7VB 205 499 509.0 LU8:501,XH1:505 Type1,Allosteric Inactive DFGin 7.014 13.512 BLAminus -126.76, 162.04 76.91, 90.47 -102.68, 21.03 302.06, 175.32 -69.9, -15.12 in-out in 8.929 Saltbr-out 4.79 HRD-in -78.61, -53.05 79.7, -1.04 out-in-out SNCoio in-out ActLoopNT-in 2.927 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.43, 165.76 APE9-dihe-na -60.04, 163.83 APE8-dihe-in -61.01, 129.39 APE8-rot-in 297.49 APE67-dihe-in -59.56, -27.34 -62.0, -41.39 APE12-dist-in 10.293 APE11-dist-out 6.183 APE10-dist-out 9.005 APE9-dist-in 3.852 Q207D None None XRAY 1.31 0.154 0.172 B 301 291 4 0 0 0 [[207, 497]] 1.0 5s7v TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7XB 205 499 509.0 LU8:501,LGA:505 Type1,Allosteric Inactive DFGin 7.031 13.379 BLAminus -128.0, 163.2 78.06, 89.3 -102.46, 20.69 301.92, 175.18 -69.56, -15.46 in-out in 8.827 Saltbr-out 4.64 HRD-in -76.89, -56.14 80.13, -1.68 out-in-out SNCoio in-out ActLoopNT-in 2.919 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.04, 166.03 APE9-dihe-na -61.79, 165.52 APE8-dihe-in -59.06, 127.18 APE8-rot-in 299.22 APE67-dihe-in -59.1, -28.73 -61.83, -40.56 APE12-dist-in 10.378 APE11-dist-out 6.165 APE10-dist-out 8.945 APE9-dist-in 3.807 Q207D None None XRAY 1.3 0.151 0.169 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s7x TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7ZB 205 499 509.0 LU8:501,BYZ:505 Type1,Allosteric Inactive DFGin 6.963 13.374 BLAminus -125.8, 161.65 77.14, 88.32 -102.44, 23.35 302.89, 177.91 -73.03, -13.12 in-out in 8.771 Saltbr-out 4.721 HRD-in -76.79, -54.43 80.82, -3.64 out-in-out SNCoio in-out ActLoopNT-in 2.92 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.61, 165.38 APE9-dihe-na -60.57, 163.68 APE8-dihe-in -58.84, 127.79 APE8-rot-in 300.37 APE67-dihe-in -58.11, -27.66 -62.19, -41.34 APE12-dist-in 10.351 APE11-dist-out 6.147 APE10-dist-out 9.002 APE9-dist-in 3.837 Q207D None None XRAY 1.3 0.163 0.184 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s7z TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S82B 205 499 509.0 LU8:501,LAC:505 Type1,Allosteric Inactive DFGin 6.655 13.398 BLAminus -126.04, 165.16 75.17, 84.42 -92.96, 20.32 298.14, 1.79 -72.8, -17.41 in-out in 8.905 Saltbr-out 4.497 HRD-in -74.85, -51.79 76.63, 2.28 out-in-in SNCoii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.55, 160.28 APE9-dihe-na 116.12, -172.15 APE8-dihe-in -92.31, 127.42 APE8-rot-in 312.53 APE67-dihe-in -58.12, -32.21 -55.48, -45.17 APE12-dist-in 11.377 APE11-dist-in 12.104 APE10-dist-in 6.253 APE9-dist-in 3.792 Q207D None None XRAY 1.71 0.211 0.253 B 301 284 11 0 0 7 [[207, 497]] 1.0 5s82 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S86B 205 499 509.0 LU8:501,XK7:505 Type1,Allosteric Inactive DFGin 7.0 13.343 BLAminus -124.78, 165.07 76.1, 88.35 -101.51, 22.18 301.71, 177.78 -69.78, -18.41 in-out in 8.888 Saltbr-out 4.745 HRD-in -81.45, -50.76 76.49, -0.86 out-in-in SNCoii in-in ActLoopNT-in 2.931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.0, 158.9 APE9-dihe-na 111.5, 158.23 APE8-dihe-in -70.2, 127.65 APE8-rot-in 298.18 APE67-dihe-in -59.26, -28.16 -59.39, -41.48 APE12-dist-in 11.628 APE11-dist-in 12.218 APE10-dist-in 6.671 APE9-dist-in 3.687 Q207D None None XRAY 1.31 0.169 0.19 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s86 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S87B 205 499 509.0 LU8:501,XKD:505 Type1,Allosteric Inactive DFGin 6.965 13.387 BLAminus -125.7, 164.87 74.71, 88.13 -101.5, 22.91 303.75, 177.62 -68.86, -17.71 in-out in 8.833 Saltbr-out 4.749 HRD-in -82.36, -52.31 79.91, -1.72 out-in-out SNCoio in-out ActLoopNT-in 2.92 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.25, 165.32 APE9-dihe-na -62.4, 164.8 APE8-dihe-in -61.06, 127.57 APE8-rot-in 297.97 APE67-dihe-in -58.73, -29.86 -59.37, -42.06 APE12-dist-in 10.243 APE11-dist-out 6.173 APE10-dist-out 8.969 APE9-dist-in 3.679 Q207D None None XRAY 1.3 0.161 0.181 B 301 290 5 0 0 0 [[207, 497]] 1.0 5s87 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S88B 205 499 509.0 LU8:501,XKS:505 Type1,Allosteric Inactive DFGin 6.973 13.376 BLAminus -122.04, 163.88 74.1, 88.2 -100.76, 18.77 302.29, 178.38 -66.87, -16.44 in-out in 8.871 Saltbr-out 4.722 HRD-in -80.9, -52.59 78.53, -3.8 out-in-out SNCoio in-out ActLoopNT-in 2.94 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.43, 164.81 APE9-dihe-na -62.32, 166.78 APE8-dihe-in -60.75, 128.44 APE8-rot-in 298.57 APE67-dihe-in -57.52, -28.98 -62.58, -40.65 APE12-dist-in 10.33 APE11-dist-out 6.149 APE10-dist-out 9.027 APE9-dist-in 3.708 Q207D None None XRAY 1.31 0.16 0.179 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s88 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S8AB 205 499 509.0 LU8:501,XKY:505 Type1,Allosteric Inactive DFGin 6.955 13.337 BLAminus -125.42, 163.04 76.47, 86.69 -100.25, 21.43 305.15, 178.88 -67.55, -16.71 in-out in 8.827 Saltbr-out 4.678 HRD-in -78.68, -54.41 80.9, -2.81 out-in-out SNCoio in-out ActLoopNT-in 2.938 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -117.78, 163.73 APE9-dihe-na -58.28, 164.12 APE8-dihe-in -61.01, 126.61 APE8-rot-in 297.82 APE67-dihe-in -58.41, -30.66 -59.54, -41.22 APE12-dist-in 10.24 APE11-dist-out 6.117 APE10-dist-out 9.04 APE9-dist-in 3.776 Q207D None None XRAY 1.3 0.158 0.179 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s8a TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
8PODA 172 498 509.0 7IO:60501,F:60502 Type1,Allosteric Inactive DFGin 7.181 13.248 BLAminus -129.23, 172.96 64.95, 88.23 -102.11, 21.22 307.17, 178.99 -69.46, -24.05 in-out in 8.75 Saltbr-out 5.24 HRD-in -77.46, -49.01 73.0, -1.63 out-in-out SNCoio in-out ActLoopNT-in 3.105 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -104.74, 151.99 APE9-dihe-na -69.89, 170.49 APE8-dihe-in -67.7, 124.46 APE8-rot-in 304.29 APE67-dihe-in -63.94, -28.35 -69.6, -32.91 APE12-dist-in 10.74 APE11-dist-out 6.542 APE10-dist-out 9.732 APE9-dist-in 4.647 None None None XRAY 2.59 0.236 0.255 A 330 320 1 0 0 0 [[207, 497]] 1.0 8pod TKL_ACVR1_HUMAN TKL 2.6e-85 292.1 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S75B 205 499 509.0 LU8:501,HUH:505,HUH:506 Type1,Allosteric,Allosteric Inactive DFGin 7.043 13.384 BLAminus -125.56, 161.73 76.89, 90.9 -104.0, 22.37 302.45, 178.35 -68.36, -16.58 in-out in 8.803 Saltbr-out 4.754 HRD-in -77.19, -54.35 79.9, -2.77 out-in-out SNCoio in-out ActLoopNT-in 2.925 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.92, 165.96 APE9-dihe-na -62.98, 165.92 APE8-dihe-in -61.22, 127.2 APE8-rot-in 298.98 APE67-dihe-in -59.47, -28.54 -61.97, -40.32 APE12-dist-in 10.373 APE11-dist-out 6.193 APE10-dist-out 8.992 APE9-dist-in 3.778 Q207D None None XRAY 1.3 0.156 0.173 B 301 293 2 0 0 0 [[207, 497]] 1.0 5s75 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S79A 202 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.359 13.307 BLAminus -117.94, 162.46 74.88, 92.31 -102.33, 24.3 297.49, 0.79 -68.18, -20.94 in-out in 9.093 Saltbr-out 5.852 HRD-in -74.67, -52.38 75.13, 0.8 out-in-out SNCoio in-out ActLoopNT-in 2.923 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -130.7, 172.52 APE9-dihe-na -62.7, 161.48 APE8-dihe-in -63.27, 127.15 APE8-rot-in 306.54 APE67-dihe-in -57.17, -31.15 -61.23, -39.7 APE12-dist-none 999.0 APE11-dist-out 6.376 APE10-dist-out 8.755 APE9-dist-in 3.742 Q207D None None XRAY 1.5 0.18 0.206 A 301 284 14 0 0 12 [[207, 497]] 1.0 5s79 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7AB 205 499 509.0 LU8:501,T5V:505,T5V:506 Type1,Allosteric,Allosteric Inactive DFGin 7.039 13.38 BLAminus -126.41, 163.07 76.94, 87.35 -100.8, 22.69 302.52, 175.53 -70.21, -15.13 in-out in 8.793 Saltbr-out 4.721 HRD-in -77.59, -56.91 81.94, -2.79 out-in-out SNCoio in-out ActLoopNT-in 2.931 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.27, 167.32 APE9-dihe-na -61.57, 164.52 APE8-dihe-in -61.32, 127.79 APE8-rot-in 299.15 APE67-dihe-in -59.77, -26.87 -62.23, -39.78 APE12-dist-in 10.33 APE11-dist-out 6.233 APE10-dist-out 8.98 APE9-dist-in 3.833 Q207D None None XRAY 1.3 0.16 0.18 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s7a TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7EA 202 499 509.0 LU8:501,LU8:508,LU8:509 Type1,Allosteric,Allosteric Inactive DFGin 8.379 13.303 BLAminus -121.44, 162.36 74.46, 91.44 -103.29, 27.05 299.26, 176.52 -69.12, -17.65 in-out in 9.178 Saltbr-out 6.106 HRD-in -79.8, -52.73 76.32, 0.43 out-in-out SNCoio in-out ActLoopNT-in 2.886 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -122.76, 172.59 APE9-dihe-na -57.54, 160.03 APE8-dihe-in -61.32, 126.08 APE8-rot-in 304.6 APE67-dihe-in -53.51, -32.05 -63.31, -40.67 APE12-dist-none 999.0 APE11-dist-out 6.308 APE10-dist-out 8.841 APE9-dist-in 3.714 Q207D None None XRAY 1.32 0.168 0.189 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s7e TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7FA 202 499 509.0 LU8:501,LU8:508,LU8:509 Type1,Allosteric,Allosteric Inactive DFGin 8.369 13.32 BLAminus -122.11, 160.49 78.65, 89.18 -101.96, 26.72 301.12, 175.97 -69.09, -20.41 in-out in 9.101 Saltbr-out 6.107 HRD-in -78.16, -52.77 77.11, -0.2 out-in-out SNCoio in-out ActLoopNT-in 2.917 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -124.41, 172.12 APE9-dihe-na -64.48, 163.27 APE8-dihe-in -60.82, 122.78 APE8-rot-in 304.26 APE67-dihe-in -57.8, -32.72 -63.43, -34.75 APE12-dist-none 999.0 APE11-dist-out 6.233 APE10-dist-out 8.851 APE9-dist-in 3.675 Q207D None None XRAY 1.31 0.151 0.169 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s7f TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7FB 205 499 509.0 LU8:501,XH4:505,XH4:506 Type1,Allosteric,Allosteric Inactive DFGin 7.004 13.386 BLAminus -125.15, 160.98 75.58, 90.9 -103.26, 20.62 302.27, 174.02 -66.35, -18.49 in-out in 8.851 Saltbr-out 4.768 HRD-in -78.67, -52.91 79.11, -3.95 out-in-out SNCoio in-out ActLoopNT-in 2.919 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.71, 164.43 APE9-dihe-na -63.66, 165.2 APE8-dihe-in -60.32, 128.18 APE8-rot-in 298.19 APE67-dihe-in -60.19, -25.76 -61.92, -39.78 APE12-dist-in 10.345 APE11-dist-out 6.114 APE10-dist-out 9.042 APE9-dist-in 3.828 Q207D None None XRAY 1.31 0.151 0.169 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s7f TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7GA 202 498 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.499 13.329 BLAminus -125.16, 165.77 74.59, 86.92 -99.45, 20.56 296.92, 176.9 -55.21, -25.24 in-out in 9.329 Saltbr-out 5.788 HRD-in -78.53, -53.51 74.34, 2.0 out-in-none SNCoin in-none ActLoopNT-in 2.902 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -116.42, 161.19 APE9-dihe-na 107.2, -168.38 APE8-dihe-in -91.58, 123.63 APE8-rot-in 309.25 APE67-dihe-in -59.99, -30.06 -55.11, -41.51 APE12-dist-none 999.0 APE11-dist-in 10.366 APE10-dist-in 6.423 APE9-dist-in 3.906 Q207D None None XRAY 1.78 0.206 0.252 A 301 284 13 0 0 13 [[207, 497]] 1.0 5s7g TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7OA 201 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.291 13.421 BLAminus -118.75, 163.36 74.89, 87.72 -99.53, 25.84 300.09, 2.07 -68.13, -17.89 in-out in 9.207 Saltbr-out 6.197 HRD-in -76.07, -55.9 78.85, -1.81 out-in-out SNCoio in-out ActLoopNT-in 2.914 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -124.0, 170.72 APE9-dihe-na -63.29, 163.84 APE8-dihe-in -60.21, 123.9 APE8-rot-in 304.44 APE67-dihe-in -59.71, -29.26 -62.37, -36.73 APE12-dist-in 11.038 APE11-dist-out 6.038 APE10-dist-out 8.868 APE9-dist-in 3.643 Q207D None None XRAY 1.43 0.165 0.189 A 301 287 12 0 0 11 [[207, 497]] 1.0 5s7o TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7QA 202 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.39 13.112 BLAminus -122.32, 165.01 69.61, 90.09 -98.74, 20.54 300.47, 4.84 -55.87, -28.73 in-out in 9.115 Saltbr-out 6.176 HRD-in -80.49, -54.34 80.36, -1.4 out-in-out SNCoio in-out ActLoopNT-in 2.933 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.26, 178.66 APE9-dihe-na -63.48, 166.31 APE8-dihe-in -61.68, 126.19 APE8-rot-in 310.31 APE67-dihe-in -52.14, -34.66 -61.41, -42.72 APE12-dist-none 999.0 APE11-dist-out 6.789 APE10-dist-out 8.89 APE9-dist-in 3.538 Q207D None None XRAY 1.53 0.209 0.243 A 301 282 16 0 0 13 [[207, 497]] 1.0 5s7q TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7UA 202 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.305 13.213 BLAminus -114.05, 162.83 73.86, 86.44 -96.11, 24.11 301.91, 5.0 -63.32, -18.47 in-out in 9.223 Saltbr-out 5.669 HRD-in -78.6, -56.95 81.06, 1.88 out-in-none SNCoin in-none ActLoopNT-in 2.888 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -102.37, -33.42 APE9-dihe-na -82.13, -169.33 APE8-dihe-in -70.61, 128.02 APE8-rot-in 308.81 APE67-dihe-in -53.65, -30.76 -61.02, -43.28 APE12-dist-none 999.0 APE11-dist-in 10.904 APE10-dist-in 6.457 APE9-dist-in 3.654 Q207D None None XRAY 1.59 0.219 0.261 A 301 280 18 0 0 13 [[207, 497]] 1.0 5s7u TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7UB 205 499 509.0 LU8:501,XGY:505,XGY:506 Type1,Allosteric,Allosteric Inactive DFGin 6.697 13.354 BLAminus -130.21, 164.61 74.6, 82.7 -94.38, 13.73 305.4, 176.35 -55.24, -22.33 in-out in 8.956 Saltbr-out 4.687 HRD-in -75.48, -53.06 77.34, -3.38 out-in-out SNCoio in-out ActLoopNT-in 2.815 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -164.99, 129.38 APE9-dihe-na -126.69, -126.94 APE8-dihe-in -91.63, 124.43 APE8-rot-in 299.73 APE67-dihe-in -58.25, -31.07 -56.39, -48.22 APE12-dist-in 10.829 APE11-dist-in 11.47 APE10-dist-out 9.514 APE9-dist-in 4.03 Q207D None None XRAY 1.59 0.219 0.261 B 301 279 16 0 0 9 [[207, 497]] 1.0 5s7u TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7VA 202 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.329 13.327 BLAminus -124.73, 163.23 77.04, 90.62 -101.21, 26.19 302.83, 177.61 -67.83, -17.56 in-out in 9.132 Saltbr-out 5.919 HRD-in -78.43, -52.77 77.91, -0.2 out-in-out SNCoio in-out ActLoopNT-in 2.93 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.42, 168.77 APE9-dihe-na -60.41, 164.86 APE8-dihe-in -63.38, 124.43 APE8-rot-in 302.99 APE67-dihe-in -57.33, -32.29 -63.57, -36.66 APE12-dist-none 999.0 APE11-dist-out 6.136 APE10-dist-out 8.877 APE9-dist-in 3.686 Q207D None None XRAY 1.31 0.154 0.172 A 301 282 16 0 0 12 [[207, 497]] 1.0 5s7v TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7WA 202 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.382 13.422 BLAminus -120.63, 163.92 74.5, 89.95 -100.48, 28.03 301.03, 179.86 -70.31, -18.41 in-out in 9.243 Saltbr-out 6.201 HRD-in -78.77, -52.99 79.89, -3.2 out-in-out SNCoio in-out ActLoopNT-in 2.94 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -122.35, 170.12 APE9-dihe-na -61.34, 168.74 APE8-dihe-in -65.88, 124.22 APE8-rot-in 304.99 APE67-dihe-in -56.25, -29.94 -63.21, -38.79 APE12-dist-none 999.0 APE11-dist-out 6.253 APE10-dist-out 8.927 APE9-dist-in 3.696 Q207D None None XRAY 1.33 0.164 0.186 A 301 284 14 0 0 13 [[207, 497]] 1.0 5s7w TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7YA 202 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.378 13.343 BLAminus -121.01, 162.15 74.22, 90.85 -101.18, 24.99 303.51, 176.94 -65.0, -19.5 in-out in 9.246 Saltbr-out 6.205 HRD-in -79.92, -53.25 77.89, -1.46 out-in-out SNCoio in-out ActLoopNT-in 2.903 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -125.05, 171.62 APE9-dihe-na -63.16, 165.02 APE8-dihe-in -61.65, 124.26 APE8-rot-in 302.58 APE67-dihe-in -56.65, -33.92 -63.4, -36.98 APE12-dist-none 999.0 APE11-dist-out 6.068 APE10-dist-out 8.872 APE9-dist-in 3.612 Q207D None None XRAY 1.37 0.161 0.184 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s7y TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S80A 202 499 509.0 LU8:501,LU8:508,LU8:509 Type1,Allosteric,Allosteric Inactive DFGin 8.314 13.306 BLAminus -112.55, 159.81 78.34, 88.26 -99.06, 22.42 300.25, 0.46 -63.75, -19.98 in-out in 9.025 Saltbr-out 5.883 HRD-in -76.34, -54.31 74.73, 2.06 out-in-out SNCoio in-out ActLoopNT-in 2.906 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -128.9, 168.55 APE9-dihe-na -54.89, 157.92 APE8-dihe-in -57.52, 122.86 APE8-rot-in 308.47 APE67-dihe-in -52.78, -30.68 -62.36, -41.16 APE12-dist-none 999.0 APE11-dist-out 6.143 APE10-dist-out 8.783 APE9-dist-in 3.735 Q207D None None XRAY 1.67 0.197 0.231 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s80 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S80B 205 499 509.0 LU8:501,XGM:505,XGM:506 Type1,Allosteric,Allosteric Inactive DFGin 7.027 13.553 BLAminus -130.83, 163.29 75.8, 86.12 -98.93, 18.93 301.48, 172.59 -65.51, -18.83 in-out in 8.969 Saltbr-out 4.718 HRD-in -78.19, -55.2 81.16, -3.45 out-in-out SNCoio in-out ActLoopNT-in 2.855 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.24, 160.71 APE9-dihe-na -59.43, 165.2 APE8-dihe-in -58.98, 127.47 APE8-rot-in 308.35 APE67-dihe-in -58.04, -28.7 -56.74, -44.6 APE12-dist-in 10.41 APE11-dist-out 6.126 APE10-dist-out 9.086 APE9-dist-in 3.811 Q207D None None XRAY 1.67 0.197 0.231 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s80 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S82A 202 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.468 13.254 BLAminus -122.58, 165.4 75.09, 85.58 -98.64, 22.96 294.39, 0.35 -56.95, -25.74 in-out in 9.336 Saltbr-out 5.524 HRD-in -76.5, -58.03 77.63, 6.82 out-in-none SNCoin in-none ActLoopNT-in 2.859 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -106.37, 156.71 APE9-dihe-na 110.11, -167.89 APE8-dihe-in -91.26, 123.24 APE8-rot-in 309.79 APE67-dihe-in -54.4, -31.68 -54.65, -45.23 APE12-dist-none 999.0 APE11-dist-in 10.894 APE10-dist-in 6.436 APE9-dist-in 3.982 Q207D None None XRAY 1.71 0.211 0.253 A 301 279 19 0 0 13 [[207, 497]] 1.0 5s82 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S87A 201 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.356 13.334 BLAminus -124.64, 162.22 77.24, 89.92 -101.8, 26.16 301.34, 177.73 -70.64, -14.84 in-out in 9.288 Saltbr-out 6.074 HRD-in -77.97, -54.71 79.68, 0.35 out-in-out SNCoio in-out ActLoopNT-in 2.932 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -122.28, 171.55 APE9-dihe-na -60.97, 165.72 APE8-dihe-in -65.13, 123.33 APE8-rot-in 301.16 APE67-dihe-in -56.7, -32.97 -59.78, -39.02 APE12-dist-none 999.0 APE11-dist-out 6.246 APE10-dist-out 9.075 APE9-dist-in 3.564 Q207D None None XRAY 1.3 0.161 0.181 A 301 284 15 0 0 13 [[207, 497]] 1.0 5s87 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S88A 202 499 509.0 LU8:501,LU8:506,LU8:507 Type1,Allosteric,Allosteric Inactive DFGin 8.391 13.328 BLAminus -125.32, 162.15 75.36, 89.99 -102.31, 27.55 301.87, 179.45 -66.0, -20.71 in-out in 9.287 Saltbr-out 6.057 HRD-in -78.45, -54.06 78.95, -0.59 out-in-out SNCoio in-out ActLoopNT-in 2.938 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -122.53, 173.56 APE9-dihe-na -66.93, 166.27 APE8-dihe-in -60.51, 123.12 APE8-rot-in 301.13 APE67-dihe-in -58.29, -28.73 -59.87, -40.21 APE12-dist-none 999.0 APE11-dist-out 6.189 APE10-dist-out 8.979 APE9-dist-in 3.598 Q207D None None XRAY 1.31 0.16 0.179 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s88 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S9KA 201 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.352 13.35 BLAminus -119.09, 162.43 73.95, 91.92 -101.37, 24.48 300.38, 179.39 -71.09, -13.1 in-out in 9.313 Saltbr-out 6.159 HRD-in -79.72, -52.91 78.84, -1.65 out-in-out SNCoio in-out ActLoopNT-in 2.927 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -122.92, 173.99 APE9-dihe-na -63.97, 163.84 APE8-dihe-in -62.03, 121.91 APE8-rot-in 301.87 APE67-dihe-in -54.23, -35.11 -55.21, -43.69 APE12-dist-none 999.0 APE11-dist-out 6.38 APE10-dist-out 9.147 APE9-dist-in 3.522 Q207D None None XRAY 1.35 0.176 0.2 A 301 281 18 0 0 13 [[207, 497]] 1.0 5s9k TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6SRHB 205 499 509.0 LU8:501,LU8:502,LU8:503 Type1,Allosteric,Allosteric Inactive DFGin 6.936 13.392 BLAminus -126.84, 164.05 75.03, 87.93 -100.83, 18.93 301.99, 177.59 -71.89, -11.94 in-out in 8.912 Saltbr-out 4.747 HRD-in -80.94, -52.46 80.13, -0.8 out-in-out SNCoio in-out ActLoopNT-in 2.925 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.66, 165.78 APE9-dihe-na -63.94, 166.94 APE8-dihe-in -62.11, 128.55 APE8-rot-in 298.15 APE67-dihe-in -60.05, -27.13 -57.77, -43.71 APE12-dist-in 10.329 APE11-dist-out 6.122 APE10-dist-out 9.07 APE9-dist-in 3.808 Q207D None None XRAY 1.25 0.134 0.16 B 301 295 0 0 0 0 [[207, 497]] 1.0 6srh TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6Z36A 202 499 509.0 Q5Z:804,Q5Z:805,Q5Z:806 Type1,Allosteric,Allosteric Inactive DFGin 8.308 13.439 BLAminus -125.01, 162.69 76.21, 87.71 -99.86, 22.76 295.6, 176.41 -67.16, -18.78 in-out in 9.193 Saltbr-out 5.877 HRD-in -79.32, -51.72 78.28, -0.5 out-in-out SNCoio in-out ActLoopNT-in 2.906 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.37, 172.12 APE9-dihe-na -68.49, 169.45 APE8-dihe-in -67.68, 126.82 APE8-rot-in 301.86 APE67-dihe-in -56.95, -28.66 -61.7, -39.93 APE12-dist-none 999.0 APE11-dist-out 6.376 APE10-dist-out 8.941 APE9-dist-in 3.767 Q207D None None XRAY 1.37 0.151 0.191 A 301 286 12 0 0 12 [[207, 497]] 1.0 6z36 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S77A 202 499 509.0 LU8:501,LU8:508,LU8:509,BAQ:510 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.391 13.291 BLAminus -123.97, 162.56 76.16, 90.86 -104.32, 25.92 302.2, 176.49 -70.33, -17.0 in-out in 9.193 Saltbr-out 6.166 HRD-in -75.36, -54.06 76.91, 1.59 out-in-out SNCoio in-out ActLoopNT-in 2.928 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.85, 171.29 APE9-dihe-na -63.22, 166.14 APE8-dihe-in -65.07, 121.84 APE8-rot-in 300.34 APE67-dihe-in -56.11, -31.98 -61.83, -38.01 APE12-dist-none 999.0 APE11-dist-out 6.3 APE10-dist-out 8.852 APE9-dist-in 3.638 Q207D None None XRAY 1.31 0.166 0.185 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s77 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7DA 202 499 509.0 LU8:501,LU8:508,LU8:509,XHD:510 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.386 13.391 BLAminus -121.08, 159.87 78.87, 90.19 -102.41, 28.04 302.41, 178.35 -70.75, -16.32 in-out in 9.224 Saltbr-out 6.135 HRD-in -78.63, -52.52 79.29, -0.45 out-in-out SNCoio in-out ActLoopNT-in 2.957 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -121.09, 171.05 APE9-dihe-na -61.33, 164.08 APE8-dihe-in -64.43, 124.8 APE8-rot-in 301.32 APE67-dihe-in -57.7, -30.13 -64.02, -36.73 APE12-dist-none 999.0 APE11-dist-out 6.226 APE10-dist-out 8.895 APE9-dist-in 3.71 Q207D None None XRAY 1.31 0.165 0.185 A 301 284 14 0 0 12 [[207, 497]] 1.0 5s7d TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7JA 201 499 509.0 LU8:501,LU8:506,LU8:507,XHG:508 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.354 13.467 BLAminus -120.47, 161.42 75.57, 90.44 -100.52, 24.64 297.99, 178.42 -66.79, -16.07 in-out in 9.118 Saltbr-out 6.109 HRD-in -76.74, -56.59 80.01, 1.36 out-in-out SNCoio in-out ActLoopNT-in 2.897 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -124.11, 169.97 APE9-dihe-na -61.08, 166.56 APE8-dihe-in -64.82, 124.61 APE8-rot-in 302.51 APE67-dihe-in -56.89, -31.73 -63.18, -39.12 APE12-dist-in 10.44 APE11-dist-out 6.043 APE10-dist-out 8.855 APE9-dist-in 3.701 Q207D None None XRAY 1.31 0.159 0.181 A 301 286 13 0 0 11 [[207, 497]] 1.0 5s7j TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7KA 202 499 509.0 LU8:501,LU8:506,LU8:507,XEJ:508 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.357 13.298 BLAminus -121.51, 161.1 74.44, 89.19 -99.73, 25.08 301.6, 0.3 -69.43, -16.12 in-out in 9.317 Saltbr-out 6.016 HRD-in -77.56, -55.15 80.71, -0.51 out-in-none SNCoin in-none ActLoopNT-in 2.929 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -93.42, -15.71 APE9-dihe-na -77.62, 169.4 APE8-dihe-in -59.03, 123.75 APE8-rot-in 304.14 APE67-dihe-in -58.63, -30.05 -60.7, -39.73 APE12-dist-none 999.0 APE11-dist-in 11.796 APE10-dist-in 6.009 APE9-dist-in 3.542 None None None XRAY 1.31 0.162 0.188 A 301 285 13 0 0 11 [[207, 497]] 1.0 5s7k TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7LA 201 499 509.0 LU8:501,LU8:507,LU8:508,XHJ:509 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.321 13.334 BLAminus -121.54, 163.42 75.33, 89.93 -101.4, 25.91 299.12, 0.16 -70.86, -16.31 in-out in 9.018 Saltbr-out 5.843 HRD-in -77.38, -52.76 78.01, -1.55 out-in-out SNCoio in-out ActLoopNT-in 2.895 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -125.9, 174.3 APE9-dihe-na -64.5, 161.75 APE8-dihe-in -61.28, 122.78 APE8-rot-in 301.43 APE67-dihe-in -55.46, -32.76 -59.71, -41.51 APE12-dist-in 10.728 APE11-dist-out 6.281 APE10-dist-out 8.784 APE9-dist-in 3.735 Q207D None None XRAY 1.36 0.167 0.188 A 301 286 13 0 0 11 [[207, 497]] 1.0 5s7l TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7MA 202 499 509.0 LU8:501,LU8:507,HVK:508,HVK:509 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.295 13.369 BLAminus -125.86, 158.69 77.31, 90.22 -102.58, 22.57 301.89, 179.15 -62.4, -27.33 in-out in 9.275 Saltbr-out 6.039 HRD-in -76.09, -53.81 76.66, 2.88 out-in-out SNCoio in-out ActLoopNT-in 2.901 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -128.0, 172.86 APE9-dihe-na -61.78, 157.6 APE8-dihe-in -61.33, 123.11 APE8-rot-in 304.71 APE67-dihe-in -54.75, -34.14 -63.89, -37.36 APE12-dist-in 11.01 APE11-dist-out 6.316 APE10-dist-out 8.773 APE9-dist-in 3.828 Q207D None None XRAY 1.32 0.171 0.195 A 301 285 13 0 0 10 [[207, 497]] 1.0 5s7m TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7NA 201 499 509.0 LU8:501,LU8:507,LU8:508,2AI:509 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.369 13.327 BLAminus -120.76, 160.23 77.83, 89.81 -101.82, 25.77 300.77, 176.65 -67.07, -19.31 in-out in 9.191 Saltbr-out 6.199 HRD-in -78.31, -53.54 78.72, -0.87 out-in-out SNCoio in-out ActLoopNT-in 2.927 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -111.12, 164.18 APE9-dihe-na -67.39, 173.07 APE8-dihe-in -61.91, 122.38 APE8-rot-in 303.15 APE67-dihe-in -57.78, -31.63 -60.2, -38.53 APE12-dist-none 999.0 APE11-dist-out 7.866 APE10-dist-out 9.173 APE9-dist-in 3.645 Q207D None None XRAY 1.3 0.163 0.186 A 301 286 13 0 0 13 [[207, 497]] 1.0 5s7n TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7PA 202 499 509.0 LU8:501,LU8:507,LU8:508,V1L:509 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.363 13.352 BLAminus -121.35, 161.97 76.5, 90.18 -103.45, 27.08 300.94, 178.65 -69.09, -20.15 in-out in 9.174 Saltbr-out 6.181 HRD-in -76.2, -55.65 77.56, 1.63 out-in-out SNCoio in-out ActLoopNT-in 2.934 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -124.42, 170.99 APE9-dihe-na -65.1, 166.64 APE8-dihe-in -64.52, 122.28 APE8-rot-in 301.0 APE67-dihe-in -57.28, -33.44 -60.97, -37.49 APE12-dist-none 999.0 APE11-dist-out 6.336 APE10-dist-out 8.81 APE9-dist-in 3.648 Q207D None None XRAY 1.31 0.158 0.176 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s7p TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7SA 202 499 509.0 LU8:501,LU8:508,LU8:509,09V:510 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.374 13.26 BLAminus -125.11, 163.99 74.48, 91.32 -103.07, 26.34 302.08, 178.93 -70.93, -18.68 in-out in 9.134 Saltbr-out 5.937 HRD-in -77.09, -53.7 75.14, 2.55 out-in-out SNCoio in-out ActLoopNT-in 2.917 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.89, 171.8 APE9-dihe-na -59.35, 163.03 APE8-dihe-in -63.02, 122.62 APE8-rot-in 301.85 APE67-dihe-in -55.53, -31.77 -61.45, -39.86 APE12-dist-in 10.584 APE11-dist-out 6.393 APE10-dist-out 8.796 APE9-dist-in 3.663 Q207D None None XRAY 1.3 0.153 0.171 A 301 287 11 0 0 9 [[207, 497]] 1.0 5s7s TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7TB 205 498 509.0 LU8:501,XGJ:505,XGJ:506,XGJ:507 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 7.348 13.384 BLAminus -130.84, 165.78 74.23, 86.23 -101.88, 22.54 301.68, 171.79 -65.62, -21.79 in-out in 8.842 Saltbr-out 4.37 HRD-in -75.87, -54.78 79.04, -1.82 out-in-out SNCoio in-out ActLoopNT-in 2.937 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -106.86, 165.74 APE9-dihe-na -60.63, 163.96 APE8-dihe-in -61.22, 126.89 APE8-rot-in 299.34 APE67-dihe-in -62.98, -26.85 -63.53, -36.43 APE12-dist-in 10.524 APE11-dist-out 6.968 APE10-dist-out 9.112 APE9-dist-in 3.886 Q207D None None XRAY 1.3 0.155 0.174 B 301 294 0 0 0 0 [[207, 497]] 1.0 5s7t TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7XA 202 499 509.0 LU8:501,LU8:508,LU8:509,LGA:510 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.365 13.339 BLAminus -120.33, 161.6 75.96, 90.47 -101.36, 24.64 300.81, 178.23 -69.2, -15.97 in-out in 9.153 Saltbr-out 6.131 HRD-in -77.36, -53.88 76.8, 3.92 out-in-out SNCoio in-out ActLoopNT-in 2.943 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.06, 170.39 APE9-dihe-na -62.49, 167.4 APE8-dihe-in -64.84, 124.15 APE8-rot-in 301.78 APE67-dihe-in -56.96, -32.72 -62.72, -36.99 APE12-dist-none 999.0 APE11-dist-out 6.228 APE10-dist-out 8.829 APE9-dist-in 3.662 Q207D None None XRAY 1.3 0.151 0.169 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s7x TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S86A 202 499 509.0 LU8:501,LU8:507,LU8:508,XK7:509 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.354 13.305 BLAminus -123.41, 163.19 74.35, 90.8 -102.12, 25.57 300.77, 178.94 -68.55, -18.48 in-out in 9.326 Saltbr-out 6.06 HRD-in -80.27, -53.89 78.04, 1.57 out-in-out SNCoio in-out ActLoopNT-in 2.929 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.39, 173.24 APE9-dihe-na -67.68, 166.72 APE8-dihe-in -62.8, 124.74 APE8-rot-in 300.74 APE67-dihe-in -57.85, -29.86 -60.17, -41.27 APE12-dist-none 999.0 APE11-dist-out 6.458 APE10-dist-out 9.142 APE9-dist-in 3.512 Q207D None None XRAY 1.31 0.169 0.19 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s86 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S89A 202 499 509.0 LU8:501,LU8:507,LU8:508,XKV:509 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.347 13.377 BLAminus -121.17, 161.16 76.55, 91.35 -102.29, 27.94 301.32, 178.72 -70.17, -17.75 in-out in 9.327 Saltbr-out 6.181 HRD-in -77.92, -53.6 79.17, 0.85 out-in-out SNCoio in-out ActLoopNT-in 2.929 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -120.5, 170.79 APE9-dihe-na -62.09, 168.52 APE8-dihe-in -64.51, 125.09 APE8-rot-in 300.94 APE67-dihe-in -58.18, -30.47 -62.43, -38.68 APE12-dist-none 999.0 APE11-dist-out 6.222 APE10-dist-out 9.136 APE9-dist-in 3.611 Q207D None None XRAY 1.3 0.156 0.174 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s89 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S8AA 202 499 509.0 LU8:501,LU8:508,LU8:509,XKY:510 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.375 13.291 BLAminus -123.48, 162.27 75.26, 91.11 -103.25, 28.11 302.42, 0.24 -70.28, -18.37 in-out in 9.291 Saltbr-out 6.087 HRD-in -77.3, -55.71 79.01, -0.21 out-in-out SNCoio in-out ActLoopNT-in 2.931 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.8, 171.85 APE9-dihe-na -62.19, 164.47 APE8-dihe-in -62.15, 125.78 APE8-rot-in 303.5 APE67-dihe-in -57.64, -30.13 -63.86, -37.62 APE12-dist-none 999.0 APE11-dist-out 6.227 APE10-dist-out 8.893 APE9-dist-in 3.683 Q207D None None XRAY 1.3 0.158 0.179 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s8a TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S8BB 205 499 509.0 LU8:501,XFV:505,XFV:506,XFV:507 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 6.886 13.268 BLAminus -123.76, 160.92 77.33, 89.17 -99.67, 18.5 303.55, 1.64 -66.62, -18.66 in-out in 8.624 Saltbr-out 4.582 HRD-in -80.97, -53.82 77.81, 1.71 out-in-out SNCoio in-out ActLoopNT-in 2.843 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.23, 169.28 APE9-dihe-na -63.35, 164.6 APE8-dihe-in -57.58, 127.02 APE8-rot-in 306.31 APE67-dihe-in -56.16, -27.82 -54.33, -48.01 APE12-dist-in 10.287 APE11-dist-out 6.129 APE10-dist-out 8.943 APE9-dist-in 3.776 Q207D None None XRAY 1.64 0.2 0.233 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s8b TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S75A 202 499 509.0 LU8:501,LU8:508,LU8:509,HUH:510,HUH:511 Type1,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.412 13.311 BLAminus -121.86, 161.2 77.57, 90.63 -103.17, 26.39 302.13, 178.97 -70.27, -17.43 in-out in 9.196 Saltbr-out 6.106 HRD-in -77.34, -53.49 77.65, 2.76 out-in-out SNCoio in-out ActLoopNT-in 2.943 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.16, 170.77 APE9-dihe-na -65.21, 166.76 APE8-dihe-in -64.6, 123.77 APE8-rot-in 302.54 APE67-dihe-in -59.09, -30.5 -61.28, -37.14 APE12-dist-none 999.0 APE11-dist-out 6.22 APE10-dist-out 8.913 APE9-dist-in 3.689 Q207D None None XRAY 1.3 0.156 0.173 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s75 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7AA 201 499 509.0 LU8:501,LU8:507,LU8:508,T5V:509,T5V:510 Type1,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.342 13.314 BLAminus -121.52, 160.72 75.85, 90.49 -101.87, 26.96 302.71, 179.1 -70.78, -16.97 in-out in 9.195 Saltbr-out 6.179 HRD-in -77.37, -53.71 77.98, -0.37 out-in-out SNCoio in-out ActLoopNT-in 2.92 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -125.86, 170.85 APE9-dihe-na -58.96, 161.85 APE8-dihe-in -63.33, 122.4 APE8-rot-in 301.84 APE67-dihe-in -56.7, -33.07 -63.45, -35.84 APE12-dist-none 999.0 APE11-dist-out 6.366 APE10-dist-out 8.852 APE9-dist-in 3.668 Q207D None None XRAY 1.3 0.16 0.18 A 301 285 14 0 0 12 [[207, 497]] 1.0 5s7a TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7BA 202 499 509.0 LU8:501,LU8:507,LU8:508,XH7:509,XH7:510 Type1,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.406 13.352 BLAminus -122.54, 161.25 77.75, 89.14 -102.53, 25.49 298.26, 177.49 -68.5, -17.41 in-out in 9.156 Saltbr-out 5.962 HRD-in -75.98, -54.72 78.12, -0.13 out-in-out SNCoio in-out ActLoopNT-in 2.908 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -121.74, 156.48 APE9-dihe-na -76.58, -177.16 APE8-dihe-in -62.22, 124.84 APE8-rot-in 304.94 APE67-dihe-in -57.93, -31.87 -59.46, -41.19 APE12-dist-out 5.286 APE11-dist-in 8.586 APE10-dist-out 9.311 APE9-dist-in 3.678 Q207D None None XRAY 1.32 0.169 0.195 A 301 285 13 0 0 10 [[207, 497]] 1.0 5s7b TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7HA 201 499 509.0 LU8:501,LU8:507,LU8:508,HVB:509,HVB:510 Type1,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.4 13.349 BLAminus -122.03, 161.2 75.68, 88.77 -99.68, 25.56 301.4, 178.71 -69.41, -15.19 in-out in 9.284 Saltbr-out 6.112 HRD-in -74.82, -53.78 79.5, -0.11 out-in-out SNCoio in-out ActLoopNT-in 2.955 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -124.66, 158.62 APE9-dihe-na -71.55, -178.8 APE8-dihe-in -67.44, 125.65 APE8-rot-in 300.35 APE67-dihe-in -57.2, -30.23 -61.33, -40.16 APE12-dist-none 999.0 APE11-dist-out 6.417 APE10-dist-out 9.333 APE9-dist-in 3.616 Q207D None None XRAY 1.3 0.158 0.18 A 301 284 15 0 0 12 [[207, 497]] 1.0 5s7h TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7ZA 202 499 509.0 LU8:501,LU8:508,LU8:509,BYZ:510,BYZ:511 Type1,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.371 13.379 BLAminus -118.29, 164.94 73.01, 90.28 -101.45, 25.18 297.95, 179.49 -66.08, -18.47 in-out in 9.035 Saltbr-out 5.816 HRD-in -75.5, -56.61 78.44, 1.56 out-in-out SNCoio in-out ActLoopNT-in 2.884 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.97, 169.25 APE9-dihe-na -61.57, 164.92 APE8-dihe-in -63.28, 125.7 APE8-rot-in 303.7 APE67-dihe-in -57.35, -34.69 -61.46, -39.19 APE12-dist-in 10.584 APE11-dist-out 6.283 APE10-dist-out 8.904 APE9-dist-in 3.732 Q207D None None XRAY 1.3 0.163 0.184 A 301 287 11 0 0 9 [[207, 497]] 1.0 5s7z TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S81B 208 499 509.0 LU8:501,XJV:505,XJV:506,XJV:507,XJV:508 Type1,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 7.098 13.469 BLAminus -122.8, 162.49 76.01, 87.95 -102.27, 24.4 302.62, 170.08 -70.81, -17.85 in-out in 8.791 Saltbr-out 4.612 HRD-in -80.16, -52.27 79.27, -5.04 out-in-out SNCoio in-out ActLoopNT-in 2.944 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.12, 164.98 APE9-dihe-na -61.51, 162.25 APE8-dihe-in -57.76, 127.22 APE8-rot-in 301.4 APE67-dihe-in -60.84, -27.37 -62.01, -41.07 APE12-dist-in 10.36 APE11-dist-out 6.197 APE10-dist-out 8.99 APE9-dist-in 3.889 Q207D None None XRAY 1.43 0.17 0.196 B 301 289 3 0 0 0 [[207, 497]] 1.0 5s81 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7CA 202 499 509.0 LU8:501,LU8:507,LU8:508,T5Y:509,T5Y:510,T5Y:511 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.339 13.345 BLAminus -122.66, 161.69 76.15, 92.72 -104.11, 24.78 300.15, 178.43 -66.33, -20.88 in-out in 9.231 Saltbr-out 6.155 HRD-in -76.23, -54.18 77.19, 0.83 out-in-out SNCoio in-out ActLoopNT-in 2.951 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -124.75, 170.87 APE9-dihe-na -60.45, 165.58 APE8-dihe-in -64.98, 123.25 APE8-rot-in 303.45 APE67-dihe-in -56.7, -31.98 -63.36, -36.72 APE12-dist-none 999.0 APE11-dist-out 6.251 APE10-dist-out 8.809 APE9-dist-in 3.72 Q207D None None XRAY 1.31 0.161 0.179 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s7c TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7IA 201 499 509.0 LU8:501,LU8:507,LU8:508,HV2:509,HV2:510,HV2:511 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.423 13.414 BLAminus -121.19, 161.49 77.75, 90.77 -102.55, 26.67 296.81, 175.99 -70.08, -16.54 in-out in 9.154 Saltbr-out 6.197 HRD-in -79.1, -52.38 76.17, 1.2 out-in-out SNCoio in-out ActLoopNT-in 2.887 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.34, 168.68 APE9-dihe-na -65.41, 166.87 APE8-dihe-in -63.35, 124.96 APE8-rot-in 301.24 APE67-dihe-in -56.97, -30.73 -63.49, -38.5 APE12-dist-none 999.0 APE11-dist-out 6.048 APE10-dist-out 8.899 APE9-dist-in 3.691 Q207D None None XRAY 1.3 0.158 0.176 A 301 284 15 0 0 13 [[207, 497]] 1.0 5s7i TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7TA 202 499 509.0 LU8:501,LU8:507,LU8:508,XGJ:509,XGJ:510,XGJ:511 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.364 13.358 BLAminus -122.53, 161.24 78.81, 92.17 -103.84, 26.27 299.68, 1.07 -70.27, -17.35 in-out in 9.187 Saltbr-out 6.102 HRD-in -73.55, -56.12 78.98, 0.06 out-in-out SNCoio in-out ActLoopNT-in 2.945 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -126.64, 169.46 APE9-dihe-na -62.74, 163.72 APE8-dihe-in -63.21, 123.01 APE8-rot-in 300.97 APE67-dihe-in -58.38, -31.17 -61.88, -38.7 APE12-dist-none 999.0 APE11-dist-out 6.217 APE10-dist-out 8.878 APE9-dist-in 3.708 Q207D None None XRAY 1.3 0.155 0.174 A 301 284 14 0 0 12 [[207, 497]] 1.0 5s7t TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7YB 207 499 509.0 LU8:501,XJP:505,XJP:506,XJP:507,XJP:508,XJP:509 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 7.015 13.427 BLAminus -126.98, 162.69 75.57, 89.14 -100.94, 21.08 303.3, 173.42 -67.07, -20.24 in-out in 8.841 Saltbr-out 4.734 HRD-in -81.6, -53.06 80.61, -4.28 out-in-out SNCoio in-out ActLoopNT-in 2.929 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.96, 164.75 APE9-dihe-na -61.91, 164.34 APE8-dihe-in -58.26, 128.88 APE8-rot-in 298.27 APE67-dihe-in -57.49, -30.88 -60.34, -41.77 APE12-dist-in 10.326 APE11-dist-out 6.153 APE10-dist-out 9.087 APE9-dist-in 3.766 Q207D None None XRAY 1.37 0.161 0.184 B 301 290 3 0 0 0 [[207, 497]] 1.0 5s7y TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7RB 205 499 509.0 LU8:501,XGS:505,XGS:506,XGS:507,XGS:508,XGS:509,XGS:510 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 6.951 13.305 BLAminus -123.51, 161.17 75.08, 89.73 -101.63, 18.32 302.56, 179.54 -66.27, -18.2 in-out in 8.728 Saltbr-out 4.754 HRD-in -80.45, -51.89 79.75, -1.22 out-in-out SNCoio in-out ActLoopNT-in 2.924 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.67, 165.96 APE9-dihe-na -61.08, 162.39 APE8-dihe-in -58.43, 128.17 APE8-rot-in 299.47 APE67-dihe-in -59.07, -29.26 -60.13, -43.27 APE12-dist-in 10.312 APE11-dist-out 6.107 APE10-dist-out 9.033 APE9-dist-in 3.879 Q207D None None XRAY 1.46 0.173 0.198 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s7r TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S85A 202 499 509.0 LU8:501,LU8:507,LU8:508,XK4:509,XK4:510,XK4:511,XK4:512 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.382 13.334 BLAminus -122.41, 161.16 77.18, 90.52 -102.57, 24.0 300.65, 177.17 -69.5, -18.6 in-out in 9.166 Saltbr-out 6.074 HRD-in -76.19, -53.3 76.63, 0.17 out-in-out SNCoio in-out ActLoopNT-in 2.905 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -127.51, 169.88 APE9-dihe-na -65.71, 163.81 APE8-dihe-in -61.83, 125.14 APE8-rot-in 302.55 APE67-dihe-in -58.05, -31.45 -63.04, -37.5 APE12-dist-none 999.0 APE11-dist-out 6.228 APE10-dist-out 8.855 APE9-dist-in 3.736 Q207D None None XRAY 1.33 0.162 0.182 A 301 282 16 0 0 13 [[207, 497]] 1.0 5s85 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S8BA 201 499 509.0 LU8:501,LU8:507,LU8:508,XFV:509,XFV:510,XFV:511,XFV:512 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.325 13.272 BLAminus -118.75, 157.39 80.5, 89.5 -103.48, 23.68 297.02, 5.33 -69.81, -17.79 in-out in 9.013 Saltbr-out 5.982 HRD-in -76.49, -52.01 73.71, 3.51 out-in-out SNCoio in-out ActLoopNT-in 2.865 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -132.81, 169.84 APE9-dihe-na -47.57, 153.77 APE8-dihe-in -59.87, 123.35 APE8-rot-in 304.85 APE67-dihe-in -51.72, -35.23 -61.3, -40.47 APE12-dist-none 999.0 APE11-dist-out 6.414 APE10-dist-out 8.81 APE9-dist-in 3.699 Q207D None None XRAY 1.64 0.2 0.233 A 301 284 15 0 0 13 [[207, 497]] 1.0 5s8b TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7RA 202 499 509.0 LU8:501,LU8:507,LU8:508,XGS:509,XGS:510,XGS:511,XGS:512,XGS:513 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.379 13.267 BLAminus -118.49, 160.3 77.59, 89.22 -102.83, 29.26 299.84, 3.52 -70.9, -18.65 in-out in 9.113 Saltbr-out 6.246 HRD-in -79.07, -53.38 77.46, -1.57 out-in-out SNCoio in-out ActLoopNT-in 2.923 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -126.05, 166.06 APE9-dihe-na -58.33, 162.52 APE8-dihe-in -61.2, 125.14 APE8-rot-in 304.32 APE67-dihe-in -53.36, -31.96 -64.07, -40.51 APE12-dist-none 999.0 APE11-dist-out 6.085 APE10-dist-out 8.947 APE9-dist-in 3.715 Q207D None None XRAY 1.46 0.173 0.198 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s7r TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7IB 205 499 509.0 LU8:501,HV2:505,HV2:506,HV2:507,HV2:508,HV2:509,HV2:510,HV2:511,HV2:512,HV2:513 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 7.03 13.347 BLAminus -124.03, 163.17 76.81, 90.06 -103.28, 20.27 301.31, 176.76 -69.97, -14.64 in-out in 8.754 Saltbr-out 4.763 HRD-in -75.19, -55.72 81.55, -2.41 out-in-out SNCoio in-out ActLoopNT-in 2.95 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.42, 164.49 APE9-dihe-na -59.34, 164.13 APE8-dihe-in -60.56, 130.0 APE8-rot-in 297.57 APE67-dihe-in -61.93, -26.2 -62.79, -39.84 APE12-dist-in 10.344 APE11-dist-out 6.121 APE10-dist-out 9.023 APE9-dist-in 3.853 Q207D None None XRAY 1.3 0.158 0.176 B 301 294 1 0 0 0 [[207, 497]] 1.0 5s7i TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S78A 202 499 509.0 LU8:501,LU8:506,LU8:507,XGV:508,XGV:509,XGV:510 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Type1 Inactive DFGin 8.324 13.355 BLAminus -121.42, 162.3 75.56, 91.97 -103.54, 25.72 302.81, 1.93 -71.55, -16.97 in-out in 9.272 Saltbr-out 6.297 HRD-in -75.89, -55.37 78.61, -0.74 out-in-out SNCoio in-out ActLoopNT-in 2.905 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -123.0, 170.53 APE9-dihe-na -61.1, 164.91 APE8-dihe-in -65.24, 123.82 APE8-rot-in 300.79 APE67-dihe-in -58.43, -30.55 -62.87, -37.3 APE12-dist-in 9.447 APE11-dist-out 6.142 APE10-dist-out 8.902 APE9-dist-in 3.676 Q207D None None XRAY 1.3 0.16 0.177 A 301 285 13 0 0 11 [[207, 497]] 1.0 5s78 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S81A 202 499 509.0 LU8:501,LU8:508,LU8:509,XJV:510,XJV:511 Type1,Allosteric,Allosteric,Allosteric,Type1 Inactive DFGin 8.317 13.29 BLAminus -119.91, 161.36 74.15, 90.65 -102.16, 24.41 299.52, 0.73 -66.2, -16.75 in-out in 9.161 Saltbr-out 6.217 HRD-in -73.39, -56.79 82.29, -0.98 out-in-out SNCoio in-out ActLoopNT-in 2.905 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -125.7, 171.05 APE9-dihe-na -60.67, 164.13 APE8-dihe-in -64.52, 125.11 APE8-rot-in 304.88 APE67-dihe-in -56.55, -33.14 -61.08, -40.13 APE12-dist-none 999.0 APE11-dist-out 6.189 APE10-dist-out 8.862 APE9-dist-in 3.68 Q207D None None XRAY 1.43 0.17 0.196 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s81 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S76A 202 499 509.0 LU8:501,LU8:507,LU8:508,02A:509,02A:510 Type1,Allosteric,Allosteric,Allosteric,Type1.5_Back Inactive DFGin 8.397 13.352 BLAminus -125.71, 163.24 76.56, 90.11 -103.29, 26.3 299.59, 179.12 -70.47, -16.36 in-out in 9.169 Saltbr-out 6.136 HRD-in -78.12, -53.94 78.79, 0.3 out-in-out SNCoio in-out ActLoopNT-in 2.91 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -121.64, 170.51 APE9-dihe-na -62.2, 167.24 APE8-dihe-in -63.35, 123.08 APE8-rot-in 302.24 APE67-dihe-in -58.65, -29.05 -63.37, -35.67 APE12-dist-none 999.0 APE11-dist-out 6.224 APE10-dist-out 8.912 APE9-dist-in 3.673 Q207D None None XRAY 1.31 0.156 0.173 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s76 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7LB 205 499 509.0 LU8:501,XHJ:505,XHJ:506,XHJ:507,XHJ:508 Type1,Allosteric,Allosteric,Allosteric,Type3 Inactive DFGin 7.111 13.39 BLAminus -125.42, 162.47 77.36, 89.52 -102.53, 17.7 300.76, 174.49 -63.63, -17.96 in-out in 8.786 Saltbr-out 4.457 HRD-in -76.1, -52.38 79.68, -4.98 out-in-out SNCoio in-out ActLoopNT-in 2.936 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -116.61, 167.49 APE9-dihe-na -61.83, 166.04 APE8-dihe-in -62.17, 127.63 APE8-rot-in 299.54 APE67-dihe-in -59.75, -27.49 -60.2, -41.98 APE12-dist-in 10.437 APE11-dist-out 6.397 APE10-dist-out 9.019 APE9-dist-in 3.894 Q207D None None XRAY 1.36 0.167 0.188 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s7l TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S84A 201 499 509.0 LU8:501,LU8:507,LU8:508,XK1:509 Type1,Allosteric,Allosteric,Type1 Inactive DFGin 8.336 13.439 BLAminus -118.42, 161.89 75.73, 89.87 -101.05, 26.48 297.86, 0.33 -68.45, -15.46 in-out in 9.125 Saltbr-out 6.08 HRD-in -77.01, -56.17 80.15, -0.22 out-in-out SNCoio in-out ActLoopNT-in 2.895 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -124.67, 170.99 APE9-dihe-na -62.03, 164.12 APE8-dihe-in -62.23, 123.92 APE8-rot-in 305.79 APE67-dihe-in -60.01, -30.93 -61.35, -38.64 APE12-dist-none 999.0 APE11-dist-out 6.133 APE10-dist-out 8.839 APE9-dist-in 3.68 Q207D None None XRAY 1.35 0.166 0.191 A 301 284 15 0 0 13 [[207, 497]] 1.0 5s84 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S83A 202 499 509.0 LU8:501,LU8:508,LU8:509,XJY:510 Type1,Allosteric,Allosteric,Type3 Inactive DFGin 8.442 13.223 BLAminus -121.45, 166.08 75.52, 89.79 -103.21, 23.07 300.9, 0.69 -66.79, -19.18 in-out in 8.966 Saltbr-out 5.632 HRD-in -77.39, -55.22 76.55, 2.24 out-in-out SNCoio in-out ActLoopNT-in 2.91 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.02, 170.52 APE9-dihe-na -63.69, 168.74 APE8-dihe-in -66.61, 121.49 APE8-rot-in 303.57 APE67-dihe-in -53.26, -35.15 -59.02, -40.84 APE12-dist-none 999.0 APE11-dist-out 6.342 APE10-dist-out 8.87 APE9-dist-in 3.756 Q207D None None XRAY 1.33 0.161 0.185 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s83 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S7OB 205 499 509.0 LU8:501,XJJ:505 Type1,Type1 Inactive DFGin 6.984 13.382 BLAminus -123.75, 162.83 73.51, 87.08 -99.67, 20.63 303.58, 175.53 -70.31, -13.4 in-out in 8.854 Saltbr-out 4.755 HRD-in -78.42, -53.12 79.9, -3.76 out-in-out SNCoio in-out ActLoopNT-in 2.942 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.12, 167.38 APE9-dihe-na -65.37, 165.19 APE8-dihe-in -58.94, 129.63 APE8-rot-in 299.85 APE67-dihe-in -59.51, -26.9 -60.64, -42.85 APE12-dist-in 10.331 APE11-dist-out 6.192 APE10-dist-out 9.027 APE9-dist-in 3.856 Q207D None None XRAY 1.43 0.165 0.189 B 301 295 0 0 0 0 [[207, 497]] 1.0 5s7o TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S85B 207 499 509.0 LU8:501,XK4:505,XK4:506,XK4:507 Type1,Type1,Allosteric,Allosteric Inactive DFGin 6.993 13.374 BLAminus -127.18, 161.1 77.88, 88.72 -101.83, 19.04 301.72, 175.14 -66.37, -15.29 in-out in 8.713 Saltbr-out 4.605 HRD-in -77.44, -53.87 79.87, -4.46 out-in-out SNCoio in-out ActLoopNT-in 2.933 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.46, 164.3 APE9-dihe-na -59.94, 165.51 APE8-dihe-in -60.21, 126.73 APE8-rot-in 299.02 APE67-dihe-in -60.44, -25.63 -60.52, -40.57 APE12-dist-in 10.351 APE11-dist-out 6.21 APE10-dist-out 9.033 APE9-dist-in 3.811 Q207D None None XRAY 1.33 0.162 0.182 B 301 290 3 0 0 0 [[207, 497]] 1.0 5s85 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S76B 205 499 509.0 LU8:501,02A:505 Type1,Type1.5_Back Inactive DFGin 7.045 13.388 BLAminus -126.37, 161.8 77.8, 87.16 -99.2, 20.64 303.2, 173.97 -68.3, -17.34 in-out in 8.888 Saltbr-out 4.735 HRD-in -77.8, -54.12 78.31, -2.4 out-in-out SNCoio in-out ActLoopNT-in 2.942 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.39, 162.33 APE9-dihe-na -57.18, 164.84 APE8-dihe-in -61.8, 127.01 APE8-rot-in 299.22 APE67-dihe-in -57.98, -30.25 -60.93, -39.7 APE12-dist-in 10.389 APE11-dist-out 6.192 APE10-dist-out 9.078 APE9-dist-in 3.758 Q207D None None XRAY 1.31 0.156 0.173 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s76 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
5S9KB 205 499 509.0 LU8:501,YV4:505 Type1,Type3 Inactive DFGin 6.899 13.311 BLAminus -124.0, 163.62 77.74, 89.17 -103.64, 24.26 305.37, 1.01 -72.01, -17.07 in-out in 8.812 Saltbr-out 4.66 HRD-in -80.23, -51.12 77.76, -2.54 out-in-out SNCoio in-out ActLoopNT-in 2.922 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.95, 165.67 APE9-dihe-na -60.95, 168.37 APE8-dihe-in -63.37, 128.29 APE8-rot-in 299.42 APE67-dihe-in -54.29, -31.02 -58.7, -45.73 APE12-dist-in 10.331 APE11-dist-out 6.186 APE10-dist-out 8.992 APE9-dist-in 3.687 Q207D None None XRAY 1.35 0.176 0.2 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s9k TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
6T6DA 204 499 509.0 MM8:501 Type1 Inactive DFGin 8.309 13.284 None -109.51, -81.12 -73.5, 111.71 -110.98, 17.65 271.3, 88.6 -66.37, -17.62 in-in in 8.137 Saltbr-in 3.496 HRD-in -71.72, -59.58 84.73, 1.24 in-in-in SNCiii in-in ActLoopNT-in 2.883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.15, 12.06 APE9-dihe-na -92.9, 178.87 APE8-dihe-in -69.31, 121.79 APE8-rot-in 306.54 APE67-dihe-in -58.18, -27.15 -60.78, -34.02 APE12-dist-in 12.163 APE11-dist-in 11.761 APE10-dist-in 6.614 APE9-dist-in 3.775 Q207D None None XRAY 2.56 0.224 0.272 A 301 292 4 0 0 4 [[207, 497]] 1.0 6t6d TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
8R7GC 206 498 509.0 YEE:501 Type1 None DFGin 7.86 12.623 BLAminus -132.3, 171.44 65.89, 83.48 -96.38, 20.1 305.34, 173.35 -63.32, -22.24 in-in in 8.155 Saltbr-in 3.027 HRD-in -79.84, -56.85 80.44, 0.82 in-in-none SNCiin in-none ActLoopNT-in 2.792 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -50.52 APE9-dihe-na -69.1, 173.0 APE8-dihe-in -60.22, 124.79 APE8-rot-in 310.22 APE67-dihe-in -65.34, -27.73 -64.05, -29.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.082 APE9-dist-in 3.578 Q207D None None XRAY 2.09 0.228 0.253 C 301 280 13 0 0 12 [[207, 497]] 1.0 8r7g TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1

TKL_ACVR1 (Activin receptor type-1)

Total number of chains: 163
Active chains: 2
Family: TKL
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 156 95.7% AF-Q04771-K1A
DFGin ABAminus 6 3.7% 6T6DB
DFGin None 1 0.6% 6T6DA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ACVR1_HUMAN AF-Q04771-K1A Q04771 200 505 509.0 No_ligand No_ligand Active DFGin 6.656 13.526 BLAminus -127.2, 176.62 56.35, 65.16 -80.71, 13.41 298.31, 0.47 -60.59, -18.71 in-in in 8.385 Saltbr-in 2.736 HRD-in -74.03, -41.1 65.71, -12.96 in-in-in SNCiii in-in ActLoopNT-in 2.861 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.22, 163.47 APE9-dihe-na 104.77, -176.02 APE8-dihe-in -80.82, 114.57 APE8-rot-in 305.54 APE67-dihe-in -59.76, -26.02 -45.29, -43.62 APE12-dist-in 11.402 APE11-dist-in 12.036 APE10-dist-in 6.213 APE9-dist-in 3.882 None None None AF2 -1.0 1.0 1.0 A 306 306 0 0 0 0 [[207, 497]] 1.0 AF-Q04771-K1 Homo sapiens TKL_ACVR1_HUMAN TKL 2e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN AF-Q04771-K3A Q04771 200 505 509.0 No_ligand No_ligand Active DFGin 6.82 13.024 BLAminus -127.84, -178.84 55.95, 50.54 -70.42, 5.27 299.08, 177.61 -61.12, -20.07 in-in in 7.973 Saltbr-in 2.703 HRD-in -75.32, -37.69 63.01, -26.16 in-in-in SNCiii in-in ActLoopNT-in 2.804 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.49, 160.87 APE9-dihe-na 125.45, 177.41 APE8-dihe-in -88.62, 117.29 APE8-rot-in 301.68 APE67-dihe-in -61.23, -22.08 -39.68, -47.95 APE12-dist-in 10.723 APE11-dist-in 11.388 APE10-dist-in 5.761 APE9-dist-in 3.877 None None None AF2 -1.0 1.0 1.0 A 306 306 0 0 0 0 [[207, 497]] 1.0 AF-Q04771-K3 Homo sapiens TKL_ACVR1_HUMAN TKL 2e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6T6DB Q04771 203 499 509.0 MM8:501 Type1 Inactive DFGin 8.025 13.457 ABAminus -113.12, -72.46 -79.26, 114.59 -109.76, 17.95 287.15, 78.17 -59.58, -33.57 in-out in 8.222 Saltbr-out 4.023 HRD-in -73.05, -64.25 87.23, -2.54 out-in-out SNCoio in-out ActLoopNT-in 2.974 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -123.53, 156.31 APE9-dihe-na -60.36, 167.63 APE8-dihe-in -59.61, 127.94 APE8-rot-in 305.34 APE67-dihe-in -62.73, -26.34 -66.57, -31.38 APE12-dist-in 10.822 APE11-dist-out 6.699 APE10-dist-out 8.867 APE9-dist-in 3.884 Q207D None None XRAY 2.56 0.224 0.272 B 301 297 0 0 0 0 [[207, 497]] 1.0 6t6d Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6T6DC Q04771 205 498 509.0 MM8:501 Type1 Inactive DFGin 7.871 12.593 ABAminus -116.62, -62.87 -95.88, 111.8 -114.2, 22.29 305.51, 0.83 -66.78, -30.11 in-out in 8.065 Saltbr-out 3.808 HRD-in -69.93, -68.13 91.02, -5.92 out-in-in SNCoii in-in ActLoopNT-in 2.828 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -97.68, 140.63 APE9-dihe-na 133.68, 172.6 APE8-dihe-in -72.52, 124.22 APE8-rot-in 299.66 APE67-dihe-in -70.69, -22.05 -69.0, -25.51 APE12-dist-in 11.262 APE11-dist-in 12.36 APE10-dist-in 6.63 APE9-dist-in 4.218 Q207D None None XRAY 2.56 0.224 0.272 C 301 278 16 0 0 11 [[207, 497]] 1.0 6t6d Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6ZGCA Q04771 205 499 509.0 H8H:501 Type1 Inactive DFGin 7.681 12.708 ABAminus -107.89, -60.92 -94.08, 111.73 -110.3, 16.97 303.67, 166.99 -67.99, -29.57 in-out in 8.661 Saltbr-out 4.532 HRD-in -76.83, -55.96 76.97, 3.64 out-in-in SNCoii in-in ActLoopNT-in 2.903 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -97.86, 149.98 APE9-dihe-na 117.18, 157.89 APE8-dihe-in -61.4, 123.56 APE8-rot-in 297.81 APE67-dihe-in -59.38, -25.03 -58.82, -36.53 APE12-dist-in 12.254 APE11-dist-in 12.368 APE10-dist-in 6.635 APE9-dist-in 4.243 Q207D None None XRAY 2.67 0.215 0.26 A 301 292 3 0 0 3 [[207, 497]] 1.0 6zgc Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6ZGCB Q04771 203 499 509.0 H8H:501 Type1 Inactive DFGin 8.059 13.076 ABAminus -110.37, -58.89 -92.47, 102.08 -108.51, 23.12 297.16, 160.33 -68.67, -30.3 in-out in 8.509 Saltbr-out 4.089 HRD-in -75.39, -56.68 79.53, 2.12 out-in-none SNCoin in-none ActLoopNT-in 3.057 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -104.09, -8.88 APE9-dihe-na -69.88, 178.01 APE8-dihe-in -69.34, 130.54 APE8-rot-in 309.97 APE67-dihe-in -59.99, -26.01 -62.71, -39.0 APE12-dist-none 999.0 APE11-dist-in 11.498 APE10-dist-in 6.693 APE9-dist-in 3.953 Q207D None None XRAY 2.67 0.215 0.26 B 301 291 6 0 0 5 [[207, 497]] 1.0 6zgc Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6ZGCC Q04771 201 498 509.0 H8H:501 Type1 Inactive DFGin 7.649 13.123 ABAminus -111.55, -59.07 -96.03, 103.07 -100.54, 20.17 312.53, 170.02 -62.85, -32.84 in-none in 8.718 Saltbr-none 999.0 HRD-in -78.56, -58.95 79.27, 6.55 none-in-out SNCnio in-out ActLoopNT-in 3.034 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -126.95, 173.39 APE9-dihe-na -60.53, 177.19 APE8-dihe-in -72.99, 133.32 APE8-rot-in 299.82 APE67-dihe-in -70.68, -22.46 -67.18, -24.36 APE12-dist-in 10.374 APE11-dist-out 7.487 APE10-dist-out 8.462 APE9-dist-in 3.917 Q207D None None XRAY 2.67 0.215 0.26 C 301 296 2 0 0 2 [[207, 497]] 1.0 6zgc Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6ZGCD Q04771 203 498 509.0 H8H:501 Type1 Inactive DFGin 8.129 12.987 ABAminus -118.4, -60.05 -92.31, 105.89 -107.46, 26.29 296.86, 166.24 -65.26, -28.18 in-out in 8.401 Saltbr-out 3.987 HRD-in -73.86, -57.34 80.97, -1.67 out-in-in SNCoii in-in ActLoopNT-in 3.024 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.47, 108.31 APE9-dihe-na 164.09, 161.61 APE8-dihe-in -63.97, 128.7 APE8-rot-in 301.77 APE67-dihe-in -60.64, -22.49 -67.87, -34.64 APE12-dist-in 12.5 APE11-dist-in 11.852 APE10-dist-in 6.463 APE9-dist-in 4.033 Q207D None None XRAY 2.67 0.215 0.26 D 301 291 5 0 0 3 [[207, 497]] 1.0 6zgc Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6UNQA Q04771 206 496 509.0 ANP:501 ATPlike Inactive DFGin 7.42 13.337 BLAminus -125.65, 175.43 76.87, 82.94 -97.73, 22.73 293.77, 158.03 -74.66, -11.32 in-out in 8.409 Saltbr-out 4.371 HRD-in -82.52, -56.03 82.09, -4.01 out-in-out SNCoio in-out ActLoopNT-in 2.814 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.89, 171.23 APE9-dihe-na -69.6, 161.61 APE8-dihe-in -54.69, 120.18 APE8-rot-in 304.53 APE67-dihe-in -58.55, -27.57 -58.47, -38.91 APE12-dist-in 10.463 APE11-dist-out 6.668 APE10-dist-out 9.075 APE9-dist-in 3.923 K493A None None XRAY 2.4 0.221 0.283 A 330 289 3 0 0 0 [[207, 497]] 1.0 6unq Homo sapiens TKL_ACVR1_HUMAN TKL 5e-85 291.3 2 266 265 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6UNRA Q04771 208 496 509.0 ANP:501 ATPlike Inactive DFGin 7.292 13.342 BLAminus -137.01, 173.22 63.77, 86.25 -97.63, 26.62 300.72, 163.44 -66.11, -21.39 in-out in 8.4 Saltbr-out 4.744 HRD-in -74.93, -61.2 87.34, -7.73 out-in-out SNCoio in-out ActLoopNT-in 2.837 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -115.39, 160.07 APE9-dihe-na -63.13, 170.03 APE8-dihe-in -59.34, 121.87 APE8-rot-in 302.11 APE67-dihe-in -65.55, -35.42 -57.38, -33.57 APE12-dist-in 10.451 APE11-dist-out 6.838 APE10-dist-out 9.11 APE9-dist-in 3.93 None None None XRAY 2.2 0.246 0.302 A 330 286 4 0 0 0 [[207, 497]] 1.0 6unr Homo sapiens TKL_ACVR1_HUMAN TKL 7.3e-85 290.8 2 266 265 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6SZMA Q04771 202 499 509.0 M2Z:501,M2Z:502,M2Z:503 Allosteric,Allosteric,Type1 Inactive DFGin 8.373 13.383 BLAminus -123.47, 160.72 76.41, 88.39 -99.15, 24.41 296.86, 175.6 -67.43, -19.78 in-out in 9.11 Saltbr-out 5.906 HRD-in -80.16, -50.98 77.51, 1.34 out-in-out SNCoio in-out ActLoopNT-in 2.898 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -127.99, 159.14 APE9-dihe-na -78.06, -171.02 APE8-dihe-in -67.19, 128.07 APE8-rot-in 301.51 APE67-dihe-in -54.87, -30.28 -61.82, -41.68 APE12-dist-in 10.132 APE11-dist-out 6.41 APE10-dist-out 9.299 APE9-dist-in 3.64 None None None XRAY 1.42 0.154 0.188 A 301 288 10 0 0 10 [[207, 497]] 1.0 6szm Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7QB Q04771 205 499 509.0 XJM:1801,LU8:1802,XJM:1806 Allosteric,Type1,Allosteric Inactive DFGin 7.035 13.341 BLAminus -124.49, 160.57 78.3, 88.59 -102.07, 16.77 299.19, 176.61 -55.48, -25.66 in-out in 8.607 Saltbr-out 4.501 HRD-in -84.23, -49.81 75.94, -2.06 out-in-out SNCoio in-out ActLoopNT-in 2.885 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -124.81, 167.47 APE9-dihe-na -59.06, 164.28 APE8-dihe-in -59.12, 123.47 APE8-rot-in 303.32 APE67-dihe-in -63.13, -25.62 -55.86, -41.03 APE12-dist-in 10.295 APE11-dist-out 6.507 APE10-dist-out 8.84 APE9-dist-in 3.744 Q207D None None XRAY 1.53 0.209 0.243 B 301 291 4 0 0 0 [[207, 497]] 1.0 5s7q Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6JUXA Q04771 203 499 509.0 C9U:501 Type1 Inactive DFGin 7.497 12.961 BLAminus -126.78, 178.97 70.86, 74.4 -92.99, 19.92 304.1, 176.2 -79.32, -9.69 in-out in 8.714 Saltbr-out 4.2 HRD-in -86.87, -53.36 72.97, 4.05 out-in-out SNCoio in-out ActLoopNT-in 2.893 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -115.09, 166.4 APE9-dihe-na -51.77, 159.85 APE8-dihe-in -52.34, 120.21 APE8-rot-in 308.99 APE67-dihe-in -56.94, -33.63 -55.65, -42.66 APE12-dist-in 10.485 APE11-dist-out 6.522 APE10-dist-out 9.018 APE9-dist-in 3.909 R206H None None XRAY 1.75 0.196 0.226 A 299 295 2 0 0 0 [[207, 497]] 1.0 6jux Homo sapiens TKL_ACVR1_HUMAN TKL 1.7e-85 292.7 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 4DYMA Q04771 207 499 509.0 IYZ:503 Type1 Inactive DFGin 7.35 12.994 BLAminus -95.12, 171.56 68.54, 94.25 -112.58, 21.32 293.39, 167.99 -72.08, -14.94 in-out in 8.886 Saltbr-out 4.563 HRD-in -84.9, -47.48 69.85, 4.05 out-in-out SNCoio in-out ActLoopNT-in 2.964 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -117.83, 177.0 APE9-dihe-na -52.44, -173.58 APE8-dihe-in -89.42, 123.68 APE8-rot-in 308.16 APE67-dihe-in -62.72, -31.35 -61.06, -26.38 APE12-dist-in 10.743 APE11-dist-out 6.841 APE10-dist-out 9.124 APE9-dist-in 3.91 R206H None None XRAY 2.42 0.271 0.279 A 301 293 0 0 0 0 [[207, 497]] 1.0 4dym Homo sapiens TKL_ACVR1_HUMAN TKL 1.8e-85 292.7 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6ACRA Q04771 203 498 509.0 9TO:501 Type1 Inactive DFGin 7.153 13.11 BLAminus -124.89, 170.02 71.35, 87.97 -99.79, 21.94 299.39, 166.61 -70.31, -13.55 in-out in 8.337 Saltbr-out 4.013 HRD-in -84.47, -53.43 78.41, -0.38 out-in-out SNCoio in-out ActLoopNT-in 2.899 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -116.18, 166.2 APE9-dihe-na -63.37, 165.5 APE8-dihe-in -62.27, 124.69 APE8-rot-in 304.34 APE67-dihe-in -61.96, -28.37 -60.94, -34.65 APE12-dist-in 10.548 APE11-dist-out 6.525 APE10-dist-out 9.133 APE9-dist-in 3.985 R206H None None XRAY 2.01 0.215 0.257 A 301 294 2 0 0 0 [[207, 497]] 1.0 6acr Homo sapiens TKL_ACVR1_HUMAN TKL 1.8e-85 292.7 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6ACRB Q04771 203 498 509.0 9TO:501 Type1 Inactive DFGin 7.378 13.12 BLAminus -127.75, 173.06 71.61, 79.74 -95.63, 20.34 301.12, 177.54 -68.09, -20.68 in-out in 8.546 Saltbr-out 4.317 HRD-in -78.48, -57.97 79.82, 2.93 out-in-out SNCoio in-out ActLoopNT-in 2.791 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -124.88, 159.1 APE9-dihe-na -64.17, 165.67 APE8-dihe-in -58.46, 129.98 APE8-rot-in 315.31 APE67-dihe-in -57.05, -29.95 -67.86, -34.69 APE12-dist-in 10.53 APE11-dist-out 6.373 APE10-dist-out 8.876 APE9-dist-in 4.015 R206H None None XRAY 2.01 0.215 0.257 B 301 293 3 0 0 0 [[207, 497]] 1.0 6acr Homo sapiens TKL_ACVR1_HUMAN TKL 1.8e-85 292.7 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 7C3GA Q04771 203 499 509.0 FH0:501 Type1 Inactive DFGin 7.452 13.12 BLAminus -120.29, 176.78 74.55, 68.82 -92.53, 16.09 299.06, 172.08 -68.72, -15.02 in-out in 8.748 Saltbr-out 3.982 HRD-in -78.99, -54.41 81.04, -2.4 out-in-out SNCoio in-out ActLoopNT-in 2.944 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -116.93, 167.94 APE9-dihe-na -56.86, 161.03 APE8-dihe-in -55.72, 122.04 APE8-rot-in 306.26 APE67-dihe-in -62.08, -30.46 -57.68, -38.77 APE12-dist-in 10.473 APE11-dist-out 6.36 APE10-dist-out 9.024 APE9-dist-in 3.996 R206H None None XRAY 1.802 0.187 0.227 A 301 294 3 0 0 0 [[207, 497]] 1.0 7c3g Homo sapiens TKL_ACVR1_HUMAN TKL 1.8e-85 292.7 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 7C3GB Q04771 204 499 509.0 FH0:501 Type1 Inactive DFGin 7.609 13.325 BLAminus -125.84, 177.88 70.8, 71.42 -95.2, 21.82 292.6, 168.16 -65.11, -21.81 in-out in 8.748 Saltbr-out 4.465 HRD-in -77.19, -58.48 86.47, -3.16 out-in-out SNCoio in-out ActLoopNT-in 2.933 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -115.68, 164.55 APE9-dihe-na -56.41, 161.05 APE8-dihe-in -56.53, 124.69 APE8-rot-in 304.77 APE67-dihe-in -57.59, -33.55 -59.78, -42.88 APE12-dist-in 10.404 APE11-dist-out 6.359 APE10-dist-out 9.141 APE9-dist-in 4.074 R206H None None XRAY 1.802 0.187 0.227 B 301 292 4 0 0 0 [[207, 497]] 1.0 7c3g Homo sapiens TKL_ACVR1_HUMAN TKL 1.8e-85 292.7 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 9L04A Q04771 203 499 509.0 A1L4C:501 Type1 Inactive DFGin 7.479 12.86 BLAminus -130.06, 174.39 69.49, 74.26 -93.18, 21.09 300.59, 12.81 -75.51, -18.04 in-out in 8.739 Saltbr-out 4.258 HRD-in -79.89, -55.04 80.17, -0.76 out-in-out SNCoio in-out ActLoopNT-in 2.844 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -113.16, 168.0 APE9-dihe-na -69.82, 167.07 APE8-dihe-in -55.37, 129.02 APE8-rot-in 307.55 APE67-dihe-in -52.45, -37.7 -69.98, -38.93 APE12-dist-in 10.484 APE11-dist-out 6.341 APE10-dist-out 8.894 APE9-dist-in 4.098 R206H None None XRAY 2.25 0.198 0.256 A 301 295 2 0 0 0 [[207, 497]] 1.0 9l04 Homo sapiens TKL_ACVR1_HUMAN TKL 1.8e-85 292.7 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 3MTFA Q04771 203 498 509.0 A3F:1 Type1 Inactive DFGin 7.09 13.208 BLAminus -126.1, 157.67 76.9, 82.69 -86.05, 21.36 306.23, 175.03 -61.66, -24.97 in-out in 8.331 Saltbr-out 4.196 HRD-in -82.54, -58.57 79.29, -1.49 out-in-out SNCoio in-out ActLoopNT-in 2.913 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -103.22, 162.67 APE9-dihe-na -69.88, 165.81 APE8-dihe-in -53.93, 121.99 APE8-rot-in 312.82 APE67-dihe-in -59.42, -28.32 -57.34, -37.41 APE12-dist-in 10.671 APE11-dist-out 6.476 APE10-dist-out 9.482 APE9-dist-in 4.073 Q207D None None XRAY 2.15 0.185 0.244 A 301 296 0 0 0 0 [[207, 497]] 1.0 3mtf Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 3MTFB Q04771 202 499 509.0 A3F:501 Type1 Inactive DFGin 7.578 13.323 BLAminus -114.45, 160.06 82.35, 87.49 -104.83, 25.86 291.12, 164.81 -75.29, -13.54 in-out in 8.5 Saltbr-out 4.232 HRD-in -82.5, -60.12 85.3, -4.39 out-in-out SNCoio in-out ActLoopNT-in 2.869 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -111.75, 153.3 APE9-dihe-na -57.45, 170.81 APE8-dihe-in -65.39, 131.64 APE8-rot-in 306.28 APE67-dihe-in -49.77, -35.33 -68.1, -43.23 APE12-dist-in 10.611 APE11-dist-out 6.453 APE10-dist-out 9.396 APE9-dist-in 4.119 Q207D None None XRAY 2.15 0.185 0.244 B 301 298 0 0 0 0 [[207, 497]] 1.0 3mtf Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 3OOMA Q04771 203 499 509.0 507:500 Type1 Inactive DFGin 7.508 13.124 BLAminus -119.72, 175.77 64.93, 85.25 -99.67, 23.22 296.73, 169.75 -72.64, -17.83 in-out in 8.556 Saltbr-out 4.701 HRD-in -77.48, -54.35 75.93, -1.97 out-in-out SNCoio in-out ActLoopNT-in 2.853 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.69, 161.89 APE9-dihe-na -56.15, 170.97 APE8-dihe-in -64.03, 124.65 APE8-rot-in 303.79 APE67-dihe-in -53.45, -34.26 -59.83, -42.52 APE12-dist-in 10.503 APE11-dist-out 6.516 APE10-dist-out 9.005 APE9-dist-in 3.811 Q207D None None XRAY 2.0 0.169 0.231 A 301 297 0 0 0 0 [[207, 497]] 1.0 3oom Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 3Q4UA Q04771 202 499 509.0 LDN:60003 Type1 Inactive DFGin 7.478 12.573 BLAminus -120.84, 173.99 68.96, 74.22 -93.95, 15.54 311.32, 10.07 -71.11, -14.74 in-out in 8.549 Saltbr-out 4.579 HRD-in -84.93, -53.09 80.07, -4.32 out-in-out SNCoio in-out ActLoopNT-in 2.789 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -114.63, 164.37 APE9-dihe-na -65.59, 171.9 APE8-dihe-in -66.34, 131.05 APE8-rot-in 305.21 APE67-dihe-in -57.96, -32.78 -63.26, -38.88 APE12-dist-in 10.559 APE11-dist-out 6.57 APE10-dist-out 9.207 APE9-dist-in 3.828 Q207D None None XRAY 1.82 0.166 0.219 A 301 298 0 0 0 0 [[207, 497]] 1.0 3q4u Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 3Q4UB Q04771 201 498 509.0 LDN:60001 Type1 Inactive DFGin 7.387 12.685 BLAminus -120.34, 167.09 70.32, 85.15 -102.45, 24.25 310.23, 168.4 -65.43, -24.12 in-out in 8.482 Saltbr-out 5.14 HRD-in -76.75, -51.74 78.96, -3.77 out-in-out SNCoio in-out ActLoopNT-in 2.844 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.85, -163.35 APE9-dihe-na -81.08, 171.54 APE8-dihe-in -58.97, 129.56 APE8-rot-in 295.83 APE67-dihe-in -56.37, -27.71 -54.93, -46.2 APE12-dist-in 11.088 APE11-dist-out 6.775 APE10-dist-out 8.729 APE9-dist-in 3.515 Q207D None None XRAY 1.82 0.166 0.219 B 301 298 0 0 0 0 [[207, 497]] 1.0 3q4u Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 3Q4UC Q04771 204 499 509.0 LDN:60004 Type1 Inactive DFGin 7.801 12.909 BLAminus -120.15, 175.41 62.84, 82.09 -94.65, 16.97 298.1, 171.75 -63.36, -27.43 in-out in 8.263 Saltbr-out 4.168 HRD-in -78.97, -53.49 75.91, -2.19 out-in-out SNCoio in-out ActLoopNT-in 2.911 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -111.55, 159.31 APE9-dihe-na -59.78, 170.44 APE8-dihe-in -70.45, 124.67 APE8-rot-in 303.37 APE67-dihe-in -52.43, -35.98 -60.31, -42.57 APE12-dist-in 10.679 APE11-dist-out 6.711 APE10-dist-out 9.362 APE9-dist-in 4.195 Q207D None None XRAY 1.82 0.166 0.219 C 301 296 0 0 0 0 [[207, 497]] 1.0 3q4u Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 3Q4UD Q04771 201 499 509.0 LDN:60002 Type1 Inactive DFGin 7.511 12.944 BLAminus -125.12, 175.24 65.52, 81.22 -96.12, 21.65 304.54, 179.82 -68.03, -22.84 in-out in 8.467 Saltbr-out 4.271 HRD-in -81.0, -52.46 76.02, -4.8 out-in-out SNCoio in-out ActLoopNT-in 2.84 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -113.41, 168.67 APE9-dihe-na -64.59, 163.68 APE8-dihe-in -59.61, 131.17 APE8-rot-in 305.46 APE67-dihe-in -53.27, -32.89 -61.06, -44.5 APE12-dist-in 10.69 APE11-dist-out 6.985 APE10-dist-out 9.135 APE9-dist-in 4.035 Q207D None None XRAY 1.82 0.166 0.219 D 301 299 0 0 0 0 [[207, 497]] 1.0 3q4u Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 4BGGA Q04771 203 498 509.0 844:1000 Type1 Inactive DFGin 7.696 13.012 BLAminus -123.75, 169.71 65.78, 89.27 -103.09, 23.33 302.35, 172.22 -60.21, -27.36 in-out in 8.613 Saltbr-out 4.459 HRD-in -75.04, -56.75 78.1, 3.09 out-in-out SNCoio in-out ActLoopNT-in 2.887 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -138.85, 172.45 APE9-dihe-na -51.51, 168.48 APE8-dihe-in -70.31, 126.41 APE8-rot-in 297.38 APE67-dihe-in -52.09, -31.08 -64.93, -41.24 APE12-dist-in 10.71 APE11-dist-out 6.48 APE10-dist-out 8.676 APE9-dist-in 3.964 Q207D None None XRAY 2.56 0.217 0.247 A 301 296 0 0 0 0 [[207, 497]] 1.0 4bgg Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 4BGGB Q04771 203 498 509.0 844:1000 Type1 Inactive DFGin 7.651 13.075 BLAminus -126.75, 170.2 64.89, 86.81 -96.93, 22.53 303.15, 172.06 -60.35, -29.64 in-out in 8.664 Saltbr-out 4.486 HRD-in -75.94, -57.13 76.77, 3.62 out-in-out SNCoio in-out ActLoopNT-in 2.897 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -139.3, 171.72 APE9-dihe-na -49.5, 168.53 APE8-dihe-in -70.36, 127.01 APE8-rot-in 296.26 APE67-dihe-in -54.49, -30.61 -64.06, -40.52 APE12-dist-in 10.752 APE11-dist-out 6.539 APE10-dist-out 8.705 APE9-dist-in 4.018 Q207D None None XRAY 2.56 0.217 0.247 B 301 293 3 0 0 0 [[207, 497]] 1.0 4bgg Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 4BGGC Q04771 204 497 509.0 844:1000 Type1 Inactive DFGin 7.671 13.139 BLAminus -121.52, 168.42 68.97, 89.32 -103.54, 23.49 302.06, 172.56 -58.81, -29.29 in-out in 8.713 Saltbr-out 4.661 HRD-in -76.71, -57.01 78.56, 1.53 out-in-out SNCoio in-out ActLoopNT-in 2.904 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -138.8, 173.51 APE9-dihe-na -53.86, 169.02 APE8-dihe-in -71.72, 126.65 APE8-rot-in 296.78 APE67-dihe-in -51.28, -31.99 -62.56, -42.69 APE12-dist-in 10.643 APE11-dist-out 6.63 APE10-dist-out 8.706 APE9-dist-in 3.97 Q207D None None XRAY 2.56 0.217 0.247 C 301 279 15 0 0 3 [[207, 497]] 1.0 4bgg Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 4BGGD Q04771 204 498 509.0 844:1000 Type1 Inactive DFGin 7.679 13.299 BLAminus -123.24, 170.49 65.5, 87.93 -101.92, 23.69 301.28, 172.56 -57.6, -28.63 in-out in 8.893 Saltbr-out 4.816 HRD-in -73.26, -58.16 80.03, 2.33 out-in-out SNCoio in-out ActLoopNT-in 2.881 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -139.49, 172.0 APE9-dihe-na -51.1, 169.58 APE8-dihe-in -71.78, 124.32 APE8-rot-in 297.27 APE67-dihe-in -52.31, -32.65 -62.65, -40.28 APE12-dist-in 10.744 APE11-dist-out 6.757 APE10-dist-out 8.675 APE9-dist-in 3.962 Q207D None None XRAY 2.56 0.217 0.247 D 301 286 9 0 0 0 [[207, 497]] 1.0 4bgg Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5OXGA Q04771 203 498 509.0 B4B:60501 Type1 Inactive DFGin 7.637 13.265 BLAminus -118.32, 174.58 68.98, 82.2 -98.18, 22.66 296.0, 151.09 -62.89, -28.13 in-out in 8.412 Saltbr-out 4.588 HRD-in -87.38, -54.01 77.94, -2.58 out-in-out SNCoio in-out ActLoopNT-in 2.899 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.81, 158.96 APE9-dihe-na -54.5, 161.85 APE8-dihe-in -60.3, 127.96 APE8-rot-in 304.93 APE67-dihe-in -54.5, -32.58 -65.84, -38.76 APE12-dist-in 10.536 APE11-dist-out 6.594 APE10-dist-out 9.125 APE9-dist-in 3.928 Q207D None None XRAY 2.13 0.207 0.232 A 301 293 3 0 0 0 [[207, 497]] 1.0 5oxg Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5OXGB Q04771 203 498 509.0 B4B:60501 Type1 Inactive DFGin 7.774 12.994 BLAminus -117.54, 172.65 67.77, 83.83 -97.74, 21.11 301.65, 151.21 -61.98, -29.72 in-out in 8.289 Saltbr-out 4.375 HRD-in -87.01, -54.36 76.79, -1.0 out-in-out SNCoio in-out ActLoopNT-in 2.894 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.05, 156.03 APE9-dihe-na -56.18, 161.08 APE8-dihe-in -61.29, 127.45 APE8-rot-in 305.02 APE67-dihe-in -55.81, -31.69 -67.18, -37.74 APE12-dist-in 10.593 APE11-dist-out 6.539 APE10-dist-out 9.168 APE9-dist-in 3.929 Q207D None None XRAY 2.13 0.207 0.232 B 301 296 0 0 0 0 [[207, 497]] 1.0 5oxg Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5OXGC Q04771 201 499 509.0 B4B:60501 Type1 Inactive DFGin 7.651 13.213 BLAminus -117.57, 174.46 68.52, 82.33 -97.58, 21.37 298.42, 152.27 -62.37, -27.96 in-out in 8.438 Saltbr-out 4.564 HRD-in -87.27, -54.15 76.99, -1.83 out-in-out SNCoio in-out ActLoopNT-in 2.901 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.01, 159.99 APE9-dihe-na -53.47, 160.0 APE8-dihe-in -61.0, 128.31 APE8-rot-in 304.03 APE67-dihe-in -52.77, -33.39 -66.51, -38.23 APE12-dist-in 10.623 APE11-dist-out 6.618 APE10-dist-out 9.051 APE9-dist-in 3.892 Q207D None None XRAY 2.13 0.207 0.232 C 301 299 0 0 0 0 [[207, 497]] 1.0 5oxg Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5OXGD Q04771 204 499 509.0 B4B:60501 Type1 Inactive DFGin 7.658 13.209 BLAminus -117.81, 173.57 68.25, 82.75 -97.79, 22.08 299.03, 151.44 -62.96, -27.82 in-out in 8.425 Saltbr-out 4.574 HRD-in -87.57, -53.89 77.97, -2.23 out-in-out SNCoio in-out ActLoopNT-in 2.901 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.11, 158.4 APE9-dihe-na -54.76, 160.73 APE8-dihe-in -60.1, 127.95 APE8-rot-in 304.17 APE67-dihe-in -54.05, -32.76 -65.2, -39.0 APE12-dist-in 10.537 APE11-dist-out 6.577 APE10-dist-out 9.122 APE9-dist-in 3.908 Q207D None None XRAY 2.13 0.207 0.232 D 301 293 3 0 0 0 [[207, 497]] 1.0 5oxg Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5OY6A Q04771 204 498 509.0 B4E:501 Type1 Inactive DFGin 8.291 13.252 BLAminus -124.42, 177.88 60.63, 75.45 -98.36, 24.99 289.66, 159.32 -68.92, -19.9 in-out in 8.639 Saltbr-out 4.821 HRD-in -67.77, -61.41 84.72, 1.07 out-in-out SNCoio in-out ActLoopNT-in 2.905 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -126.92, 159.12 APE9-dihe-na -54.75, 165.03 APE8-dihe-in -63.11, 127.19 APE8-rot-in 306.42 APE67-dihe-in -58.96, -26.1 -63.39, -37.66 APE12-dist-in 10.889 APE11-dist-out 7.509 APE10-dist-out 9.159 APE9-dist-in 4.058 Q207D None None XRAY 2.56 0.213 0.242 A 301 291 4 0 0 4 [[207, 497]] 1.0 5oy6 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5OY6B Q04771 203 498 509.0 B4E:501 Type1 Inactive DFGin 8.248 13.333 BLAminus -125.87, 178.71 61.82, 75.85 -101.33, 26.17 288.46, 162.63 -69.08, -20.03 in-out in 8.515 Saltbr-out 4.198 HRD-in -68.95, -63.27 85.74, 0.17 out-in-out SNCoio in-out ActLoopNT-in 2.958 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -127.6, 156.0 APE9-dihe-na -54.68, 165.41 APE8-dihe-in -64.35, 128.25 APE8-rot-in 306.22 APE67-dihe-in -62.96, -21.48 -62.63, -39.13 APE12-dist-in 10.681 APE11-dist-out 6.629 APE10-dist-out 9.201 APE9-dist-in 4.059 Q207D None None XRAY 2.56 0.213 0.242 B 301 292 4 0 0 4 [[207, 497]] 1.0 5oy6 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5OY6C Q04771 204 498 509.0 B4E:501 Type1 Inactive DFGin 7.783 13.737 BLAminus -125.03, 177.56 62.78, 78.08 -98.08, 25.7 291.29, 112.83 -67.62, -20.85 in-out in 8.707 Saltbr-out 4.666 HRD-in -66.74, -64.66 88.1, -0.91 out-in-out SNCoio in-out ActLoopNT-in 2.967 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -127.72, 150.97 APE9-dihe-na -57.32, 166.0 APE8-dihe-in -62.6, 125.98 APE8-rot-in 304.73 APE67-dihe-in -60.45, -23.22 -63.39, -39.0 APE12-dist-in 10.806 APE11-dist-out 7.01 APE10-dist-out 9.245 APE9-dist-in 4.096 Q207D None None XRAY 2.56 0.213 0.242 C 301 291 4 0 0 4 [[207, 497]] 1.0 5oy6 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5OY6D Q04771 204 499 509.0 B4E:501 Type1 Inactive DFGin 8.291 13.546 BLAminus -127.17, 177.39 63.16, 77.76 -100.16, 30.24 284.06, 110.55 -69.39, -22.09 in-none in 8.571 Saltbr-none 999.0 HRD-in -68.36, -61.68 86.2, 0.92 none-in-out SNCnio in-out ActLoopNT-in 2.896 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -128.01, 153.71 APE9-dihe-na -55.98, 170.12 APE8-dihe-in -61.71, 125.91 APE8-rot-in 305.4 APE67-dihe-in -60.01, -22.62 -62.93, -40.3 APE12-dist-in 10.633 APE11-dist-out 6.805 APE10-dist-out 9.067 APE9-dist-in 3.995 Q207D None None XRAY 2.56 0.213 0.242 D 301 292 4 0 0 4 [[207, 497]] 1.0 5oy6 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S77B Q04771 205 499 509.0 LU8:501 Type1 Inactive DFGin 7.031 13.453 BLAminus -124.57, 162.89 76.44, 87.16 -99.57, 19.41 300.08, 174.78 -68.76, -14.31 in-out in 8.853 Saltbr-out 4.653 HRD-in -77.29, -55.2 78.52, -0.63 out-in-out SNCoio in-out ActLoopNT-in 2.946 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.24, 166.6 APE9-dihe-na -61.81, 164.74 APE8-dihe-in -60.61, 127.64 APE8-rot-in 298.26 APE67-dihe-in -59.97, -28.12 -61.67, -40.13 APE12-dist-in 10.37 APE11-dist-out 6.209 APE10-dist-out 8.996 APE9-dist-in 3.824 Q207D None None XRAY 1.31 0.166 0.185 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s77 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S78B Q04771 208 499 509.0 LU8:501 Type1 Inactive DFGin 6.992 13.404 BLAminus -126.64, 164.14 74.77, 87.97 -101.18, 22.29 302.33, 177.25 -70.25, -15.52 in-out in 8.801 Saltbr-out 4.684 HRD-in -78.72, -53.62 78.73, -3.65 out-in-out SNCoio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.7, 165.64 APE9-dihe-na -61.72, 165.79 APE8-dihe-in -60.78, 129.07 APE8-rot-in 300.39 APE67-dihe-in -58.83, -27.2 -62.73, -40.71 APE12-dist-in 10.205 APE11-dist-out 6.245 APE10-dist-out 9.047 APE9-dist-in 3.86 Q207D None None XRAY 1.3 0.16 0.177 B 301 292 0 0 0 0 [[207, 497]] 1.0 5s78 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S79B Q04771 208 498 509.0 LU8:501 Type1 Inactive DFGin 6.949 13.409 BLAminus -122.03, 163.17 76.24, 92.19 -103.59, 21.82 301.57, 173.56 -69.99, -14.55 in-out in 8.607 Saltbr-out 3.776 HRD-in -77.29, -54.6 79.65, 0.11 out-in-out SNCoio in-out ActLoopNT-in 2.903 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -123.19, 173.51 APE9-dihe-na -67.77, 168.43 APE8-dihe-in -60.9, 124.36 APE8-rot-in 301.89 APE67-dihe-in -54.42, -27.95 -56.48, -46.08 APE12-dist-in 10.363 APE11-dist-out 6.644 APE10-dist-out 8.916 APE9-dist-in 3.749 Q207D None None XRAY 1.5 0.18 0.206 B 301 288 3 0 0 0 [[207, 497]] 1.0 5s79 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7GB Q04771 207 499 509.0 LU8:501 Type1 Inactive DFGin 6.641 13.495 BLAminus -119.72, 159.88 82.75, 87.21 -98.63, 18.92 305.17, 0.99 -67.48, -19.33 in-out in 9.017 Saltbr-out 4.958 HRD-in -77.01, -50.93 75.96, 1.34 out-in-none SNCoin in-none ActLoopNT-in 2.966 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -89.52, 148.19 APE9-dihe-na 117.39, 161.66 APE8-dihe-in -69.4, 128.02 APE8-rot-in 308.42 APE67-dihe-in -59.26, -33.51 -60.94, -38.65 APE12-dist-none 999.0 APE11-dist-in 11.662 APE10-dist-in 5.817 APE9-dist-in 3.942 Q207D None None XRAY 1.78 0.206 0.252 B 301 281 12 0 0 8 [[207, 497]] 1.0 5s7g Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7HB Q04771 205 499 509.0 LU8:501 Type1 Inactive DFGin 7.002 13.387 BLAminus -126.96, 163.26 76.81, 86.99 -100.87, 23.04 301.4, 176.52 -72.34, -14.12 in-out in 8.835 Saltbr-out 4.759 HRD-in -77.49, -53.08 77.02, -2.86 out-in-out SNCoio in-out ActLoopNT-in 2.943 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.19, 165.21 APE9-dihe-na -62.02, 164.93 APE8-dihe-in -59.21, 129.08 APE8-rot-in 298.47 APE67-dihe-in -58.12, -30.1 -64.15, -39.55 APE12-dist-in 10.313 APE11-dist-out 6.162 APE10-dist-out 9.011 APE9-dist-in 3.728 Q207D None None XRAY 1.3 0.158 0.18 B 301 293 2 0 0 0 [[207, 497]] 1.0 5s7h Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7JB Q04771 206 499 509.0 LU8:501 Type1 Inactive DFGin 6.972 13.39 BLAminus -125.59, 163.92 74.27, 89.45 -104.09, 21.89 302.89, 178.4 -70.85, -13.4 in-out in 8.791 Saltbr-out 4.723 HRD-in -74.57, -55.28 81.04, -2.31 out-in-out SNCoio in-out ActLoopNT-in 2.944 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.08, 165.49 APE9-dihe-na -60.51, 165.0 APE8-dihe-in -60.32, 128.5 APE8-rot-in 300.26 APE67-dihe-in -54.83, -31.02 -61.2, -43.09 APE12-dist-in 10.355 APE11-dist-out 6.167 APE10-dist-out 9.033 APE9-dist-in 3.806 Q207D None None XRAY 1.31 0.159 0.181 B 301 291 3 0 0 0 [[207, 497]] 1.0 5s7j Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7PB Q04771 208 499 509.0 LU8:501 Type1 Inactive DFGin 7.041 13.42 BLAminus -127.32, 160.61 79.2, 88.36 -101.38, 20.66 301.74, 174.56 -69.08, -14.59 in-out in 8.838 Saltbr-out 4.749 HRD-in -79.58, -51.94 76.5, -1.66 out-in-out SNCoio in-out ActLoopNT-in 2.946 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.23, 166.15 APE9-dihe-na -60.81, 164.72 APE8-dihe-in -59.48, 128.85 APE8-rot-in 300.38 APE67-dihe-in -62.62, -25.57 -64.98, -36.96 APE12-dist-in 10.458 APE11-dist-out 6.192 APE10-dist-out 8.971 APE9-dist-in 3.87 Q207D None None XRAY 1.31 0.158 0.176 B 301 289 3 0 0 0 [[207, 497]] 1.0 5s7p Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7WB Q04771 205 499 509.0 LU8:501 Type1 Inactive DFGin 7.03 13.401 BLAminus -127.76, 159.78 80.36, 85.76 -99.88, 21.09 305.52, 179.19 -65.9, -24.32 in-out in 8.94 Saltbr-out 4.819 HRD-in -77.42, -54.04 83.37, -7.62 out-in-out SNCoio in-out ActLoopNT-in 2.958 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -116.09, 164.43 APE9-dihe-na -60.72, 165.96 APE8-dihe-in -63.25, 128.46 APE8-rot-in 296.55 APE67-dihe-in -59.57, -28.14 -60.1, -41.66 APE12-dist-in 10.317 APE11-dist-out 6.247 APE10-dist-out 9.071 APE9-dist-in 3.811 Q207D None None XRAY 1.33 0.164 0.186 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s7w Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S83B Q04771 205 499 509.0 LU8:501 Type1 Inactive DFGin 7.033 13.478 BLAminus -124.19, 162.22 78.06, 86.57 -101.53, 19.96 300.51, 175.3 -64.11, -18.65 in-out in 8.89 Saltbr-out 4.771 HRD-in -75.73, -55.05 82.15, -4.6 out-in-out SNCoio in-out ActLoopNT-in 2.954 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.26, 164.39 APE9-dihe-na -61.1, 166.22 APE8-dihe-in -61.61, 128.13 APE8-rot-in 300.62 APE67-dihe-in -58.81, -29.24 -62.24, -41.18 APE12-dist-in 10.424 APE11-dist-out 6.285 APE10-dist-out 9.037 APE9-dist-in 3.856 Q207D None None XRAY 1.33 0.161 0.185 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s83 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S84B Q04771 206 499 509.0 LU8:501 Type1 Inactive DFGin 6.988 13.448 BLAminus -125.42, 163.93 74.98, 89.22 -103.06, 18.19 302.78, 175.41 -63.64, -17.13 in-out in 8.82 Saltbr-out 4.668 HRD-in -75.34, -54.28 80.29, -2.12 out-in-out SNCoio in-out ActLoopNT-in 2.916 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.41, 168.09 APE9-dihe-na -59.7, 163.97 APE8-dihe-in -58.67, 126.71 APE8-rot-in 301.06 APE67-dihe-in -57.69, -26.63 -61.25, -41.61 APE12-dist-in 10.345 APE11-dist-out 6.2 APE10-dist-out 9.014 APE9-dist-in 3.864 Q207D None None XRAY 1.35 0.166 0.191 B 301 291 3 0 0 0 [[207, 497]] 1.0 5s84 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S89B Q04771 205 499 509.0 LU8:501 Type1 Inactive DFGin 6.984 13.361 BLAminus -124.97, 163.75 76.76, 88.69 -102.06, 21.8 303.74, 177.29 -68.27, -19.19 in-out in 8.866 Saltbr-out 4.772 HRD-in -81.65, -52.32 78.48, -1.17 out-in-out SNCoio in-out ActLoopNT-in 2.922 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -117.77, 165.98 APE9-dihe-na -60.57, 167.11 APE8-dihe-in -63.21, 128.67 APE8-rot-in 299.1 APE67-dihe-in -57.43, -30.6 -61.18, -42.41 APE12-dist-in 10.276 APE11-dist-out 6.198 APE10-dist-out 8.992 APE9-dist-in 3.71 Q207D None None XRAY 1.3 0.156 0.174 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s89 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6GI6A Q04771 202 499 509.0 EZB:501 Type1 Inactive DFGin 7.422 13.322 BLAminus -127.88, 173.46 70.43, 82.55 -98.0, 26.87 288.66, 156.94 -67.23, -24.52 in-out in 8.499 Saltbr-out 4.338 HRD-in -79.97, -60.56 85.58, -0.98 out-in-out SNCoio in-out ActLoopNT-in 2.807 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -117.79, 141.92 APE9-dihe-na -55.69, 163.56 APE8-dihe-in -58.02, 123.22 APE8-rot-in 303.81 APE67-dihe-in -57.31, -31.72 -64.44, -36.13 APE12-dist-in 10.721 APE11-dist-out 6.48 APE10-dist-out 9.557 APE9-dist-in 4.129 Q207D None None XRAY 1.98 0.213 0.263 A 301 298 0 0 0 0 [[207, 497]] 1.0 6gi6 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6GINA Q04771 204 499 509.0 IR2:501 Type1 Inactive DFGin 7.879 13.312 BLAminus -121.27, 164.65 78.13, 83.84 -95.5, 20.22 297.8, 169.45 -69.16, -15.6 in-out in 8.878 Saltbr-out 4.872 HRD-in -75.63, -62.52 83.49, -5.41 out-in-out SNCoio in-out ActLoopNT-in 2.931 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.0, 167.37 APE9-dihe-na -63.42, 166.06 APE8-dihe-in -62.49, 126.47 APE8-rot-in 300.53 APE67-dihe-in -54.65, -29.35 -62.43, -43.34 APE12-dist-in 10.665 APE11-dist-out 6.722 APE10-dist-out 9.047 APE9-dist-in 3.915 Q207D None None XRAY 2.2 0.175 0.228 A 301 296 0 0 0 0 [[207, 497]] 1.0 6gin Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6GINB Q04771 204 499 509.0 IR2:501 Type1 Inactive DFGin 8.47 13.255 BLAminus -117.85, 169.5 76.39, 82.56 -95.36, 20.36 297.72, 170.4 -61.59, -30.68 in-out in 9.121 Saltbr-out 5.23 HRD-in -83.85, -57.15 83.89, -5.86 out-in-out SNCoio in-out ActLoopNT-in 2.924 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -128.3, 164.88 APE9-dihe-na -62.2, 169.83 APE8-dihe-in -64.53, 122.81 APE8-rot-in 301.07 APE67-dihe-in -53.52, -33.94 -60.13, -39.73 APE12-dist-in 10.724 APE11-dist-out 6.78 APE10-dist-out 8.739 APE9-dist-in 3.947 Q207D None None XRAY 2.2 0.175 0.228 B 301 296 0 0 0 0 [[207, 497]] 1.0 6gin Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6GIPA Q04771 204 499 509.0 EUN:501 Type1 Inactive DFGin 7.414 13.505 BLAminus -121.32, 176.37 70.61, 86.28 -96.75, 17.14 284.62, 145.48 -62.03, -23.64 in-out in 8.437 Saltbr-out 4.259 HRD-in -82.34, -53.01 79.89, 0.83 out-in-out SNCoio in-out ActLoopNT-in 2.829 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -112.13, 155.12 APE9-dihe-na -62.81, 175.41 APE8-dihe-in -72.99, 121.09 APE8-rot-in 307.8 APE67-dihe-in -54.26, -31.45 -59.06, -38.64 APE12-dist-in 10.533 APE11-dist-out 6.593 APE10-dist-out 9.307 APE9-dist-in 4.177 Q207D None None XRAY 2.17 0.195 0.239 A 301 296 0 0 0 0 [[207, 497]] 1.0 6gip Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6SRHA Q04771 201 499 509.0 LU8:501 Type1 Inactive DFGin 8.337 13.442 BLAminus -122.57, 162.03 75.26, 88.46 -99.42, 24.23 300.0, 175.86 -68.83, -17.25 in-out in 9.271 Saltbr-out 6.184 HRD-in -78.85, -52.97 79.59, -0.55 out-in-out SNCoio in-out ActLoopNT-in 2.952 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.6, 171.91 APE9-dihe-na -65.69, 166.15 APE8-dihe-in -64.37, 126.3 APE8-rot-in 301.19 APE67-dihe-in -57.05, -29.89 -63.28, -37.95 APE12-dist-in 10.996 APE11-dist-out 6.191 APE10-dist-out 8.89 APE9-dist-in 3.672 Q207D None None XRAY 1.25 0.134 0.16 A 301 288 11 0 0 11 [[207, 497]] 1.0 6srh Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6SZMB Q04771 205 499 509.0 M2Z:501 Type1 Inactive DFGin 6.889 13.38 BLAminus -130.45, 165.06 76.0, 85.65 -99.23, 20.14 303.49, 173.6 -70.24, -14.21 in-out in 8.854 Saltbr-out 4.716 HRD-in -80.29, -50.69 76.82, 0.43 out-in-out SNCoio in-out ActLoopNT-in 2.943 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.93, 162.59 APE9-dihe-na -62.54, 170.01 APE8-dihe-in -65.85, 128.73 APE8-rot-in 300.13 APE67-dihe-in -58.84, -26.54 -57.25, -44.85 APE12-dist-in 10.309 APE11-dist-out 6.286 APE10-dist-out 9.077 APE9-dist-in 3.776 None None None XRAY 1.42 0.154 0.188 B 301 295 0 0 0 0 [[207, 497]] 1.0 6szm Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6T6DD Q04771 203 498 509.0 MM8:501 Type1 Inactive DFGin 7.617 12.599 BLAminus -126.5, 165.83 73.29, 84.55 -98.79, 17.26 305.85, 171.23 -61.04, -35.17 in-out in 8.139 Saltbr-out 5.221 HRD-in -66.75, -60.44 83.42, 7.04 out-in-none SNCoin in-none ActLoopNT-in 2.729 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -100.75, 149.74 APE9-dihe-na 135.34, 156.1 APE8-dihe-in -58.61, 125.21 APE8-rot-in 305.55 APE67-dihe-in -57.51, -24.77 -65.16, -37.29 APE12-dist-none 999.0 APE11-dist-in 10.268 APE10-dist-in 6.797 APE9-dist-in 4.182 Q207D None None XRAY 2.56 0.224 0.272 D 301 285 11 0 0 11 [[207, 497]] 1.0 6t6d Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6T8NA Q04771 203 498 509.0 MVE:604 Type1 Inactive DFGin 8.239 13.54 BLAminus -117.22, 176.03 72.91, 63.91 -91.39, 23.17 287.75, 168.53 -67.92, -18.8 in-out in 8.933 Saltbr-out 4.707 HRD-in -84.95, -51.56 81.75, -3.33 out-in-out SNCoio in-out ActLoopNT-in 2.815 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.51, 167.12 APE9-dihe-na -61.87, 158.02 APE8-dihe-in -61.33, 127.98 APE8-rot-in 306.21 APE67-dihe-in -60.03, -27.55 -64.05, -36.62 APE12-dist-in 10.612 APE11-dist-out 6.629 APE10-dist-out 9.087 APE9-dist-in 4.125 Q207D None None XRAY 1.77 0.205 0.237 A 301 293 3 0 0 0 [[207, 497]] 1.0 6t8n Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6T8NB Q04771 203 499 509.0 MVE:606 Type1 Inactive DFGin 8.566 13.447 BLAminus -115.44, -178.9 71.98, 70.18 -99.66, 24.02 289.42, 166.62 -70.33, -17.84 in-out in 9.075 Saltbr-out 4.916 HRD-in -81.57, -50.67 76.26, -0.18 out-in-out SNCoio in-out ActLoopNT-in 2.9 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.64, 165.39 APE9-dihe-na -58.57, 157.21 APE8-dihe-in -58.07, 130.83 APE8-rot-in 301.01 APE67-dihe-in -55.44, -32.97 -60.5, -39.92 APE12-dist-in 10.528 APE11-dist-out 6.381 APE10-dist-out 9.178 APE9-dist-in 4.038 Q207D None None XRAY 1.77 0.205 0.237 B 301 293 4 0 0 0 [[207, 497]] 1.0 6t8n Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6TN8A Q04771 204 499 509.0 5U6:505 Type1 Inactive DFGin 7.003 13.652 BLAminus -130.26, 163.23 78.2, 92.28 -100.4, 19.39 297.25, 1.05 -69.42, -14.3 in-out in 8.615 Saltbr-out 5.966 HRD-in -83.31, -56.24 82.45, -1.3 out-in-out SNCoio in-out ActLoopNT-in 2.875 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -117.0, 166.36 APE9-dihe-na -66.52, 164.84 APE8-dihe-in -59.49, 124.33 APE8-rot-in 302.89 APE67-dihe-in -55.89, -27.94 -60.94, -41.66 APE12-dist-in 10.406 APE11-dist-out 6.468 APE10-dist-out 9.121 APE9-dist-in 3.731 None None None XRAY 1.63 0.23 0.262 A 301 296 0 0 0 0 [[207, 497]] 1.0 6tn8 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6Z36B Q04771 204 498 509.0 Q5Z:603 Type1 Inactive DFGin 6.88 13.527 BLAminus -126.16, 165.21 76.57, 84.99 -100.04, 20.28 298.99, 173.38 -68.85, -18.38 in-out in 8.893 Saltbr-out 4.65 HRD-in -80.23, -52.08 77.68, -0.84 out-in-out SNCoio in-out ActLoopNT-in 2.974 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.07, 163.14 APE9-dihe-na -61.96, 174.49 APE8-dihe-in -69.93, 128.14 APE8-rot-in 297.68 APE67-dihe-in -61.25, -26.77 -56.9, -42.94 APE12-dist-in 10.414 APE11-dist-out 6.324 APE10-dist-out 9.049 APE9-dist-in 3.799 Q207D None None XRAY 1.37 0.151 0.191 B 301 293 2 0 0 0 [[207, 497]] 1.0 6z36 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 7A21A Q04771 203 498 509.0 QWQ:501 Type1 Inactive DFGin 7.382 13.169 BLAminus -127.76, 158.55 80.05, 87.13 -96.73, 14.66 294.42, 153.21 -62.06, -21.0 in-out in 8.323 Saltbr-out 4.348 HRD-in -78.22, -57.26 78.46, 2.93 out-in-out SNCoio in-out ActLoopNT-in 2.806 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -127.16, 161.76 APE9-dihe-na -62.55, 162.64 APE8-dihe-in -58.51, 125.54 APE8-rot-in 301.03 APE67-dihe-in -51.19, -25.85 -61.35, -46.92 APE12-dist-in 10.598 APE11-dist-out 6.485 APE10-dist-out 9.161 APE9-dist-in 3.838 Q207D None None XRAY 2.14 0.21 0.256 A 301 296 0 0 0 0 [[207, 497]] 1.0 7a21 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 7A21B Q04771 203 498 509.0 QWQ:501 Type1 Inactive DFGin 8.551 13.425 BLAminus -134.98, 161.81 74.98, 86.69 -95.85, 23.59 296.34, 175.33 -57.61, -25.52 in-out in 8.645 Saltbr-out 5.44 HRD-in -82.57, -62.71 85.35, -0.84 out-in-out SNCoio in-out ActLoopNT-in 2.721 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -126.21, 168.9 APE9-dihe-na -61.22, 161.93 APE8-dihe-in -55.41, 123.95 APE8-rot-in 309.75 APE67-dihe-in -53.39, -33.78 -63.89, -37.45 APE12-dist-in 10.776 APE11-dist-out 6.54 APE10-dist-out 9.09 APE9-dist-in 3.9 Q207D None None XRAY 2.14 0.21 0.256 B 301 296 0 0 0 0 [[207, 497]] 1.0 7a21 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 7NNSB Q04771 204 499 509.0 C87:507 Type1 Inactive DFGin 8.06 12.82 BLAminus -133.17, -176.16 65.22, 65.05 -96.55, 15.24 297.87, 150.85 -66.46, -15.55 in-out in 8.801 Saltbr-out 5.094 HRD-in -81.45, -57.24 85.72, -1.07 out-in-out SNCoio in-out ActLoopNT-in 2.913 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -113.15, 156.87 APE9-dihe-na -64.22, 158.78 APE8-dihe-in -55.79, 124.56 APE8-rot-in 304.92 APE67-dihe-in -55.54, -37.05 -65.15, -36.45 APE12-dist-in 10.499 APE11-dist-out 6.32 APE10-dist-out 9.652 APE9-dist-in 4.531 Q207D None None XRAY 2.14 0.23 0.269 B 301 296 0 0 0 0 [[207, 497]] 1.0 7nns Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 8C7WA Q04771 202 499 509.0 U0C:501 Type1 Inactive DFGin 7.204 13.051 BLAminus -128.22, 168.64 69.43, 93.94 -103.93, 18.54 295.47, 153.77 -65.01, -20.19 in-out in 8.678 Saltbr-out 4.471 HRD-in -82.72, -56.02 79.41, 2.44 out-in-out SNCoio in-out ActLoopNT-in 2.965 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -108.26, 150.44 APE9-dihe-na -62.04, 172.48 APE8-dihe-in -69.23, 126.84 APE8-rot-in 300.76 APE67-dihe-in -67.12, -32.26 -66.04, -29.76 APE12-dist-in 10.583 APE11-dist-out 6.189 APE10-dist-out 9.621 APE9-dist-in 4.225 Q207D None None XRAY 2.26 0.209 0.239 A 301 298 0 0 0 0 [[207, 497]] 1.0 8c7w Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 8C7ZA Q04771 204 498 509.0 TZX:502 Type1 Inactive DFGin 7.001 13.539 BLAminus -129.04, 178.53 61.89, 92.69 -101.8, 21.5 274.24, 128.16 -70.35, -21.45 in-out in 8.56 Saltbr-out 4.534 HRD-in -77.94, -53.22 74.05, 9.22 out-in-out SNCoio in-out ActLoopNT-in 2.836 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -104.81, 151.04 APE9-dihe-na -67.81, 170.33 APE8-dihe-in -65.57, 126.09 APE8-rot-in 307.68 APE67-dihe-in -60.34, -30.84 -67.16, -35.46 APE12-dist-in 10.599 APE11-dist-out 6.39 APE10-dist-out 9.707 APE9-dist-in 4.192 Q207D None None XRAY 2.23 0.216 0.261 A 301 295 0 0 0 0 [[207, 497]] 1.0 8c7z Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 8R7GA Q04771 205 499 509.0 YEE:501 Type1 Inactive DFGin 7.873 13.114 BLAminus -125.34, 176.57 61.75, 79.56 -92.18, 25.14 304.23, 156.54 -66.96, -22.65 in-out in 8.25 Saltbr-out 4.604 HRD-in -86.83, -53.56 76.37, 0.62 out-in-out SNCoio in-out ActLoopNT-in 3.003 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -99.53, 168.92 APE9-dihe-na -60.18, 166.2 APE8-dihe-in -61.99, 126.25 APE8-rot-in 300.64 APE67-dihe-in -53.95, -28.13 -65.83, -38.49 APE12-dist-in 10.96 APE11-dist-out 7.324 APE10-dist-out 9.123 APE9-dist-in 3.874 Q207D None None XRAY 2.09 0.228 0.253 A 301 293 2 0 0 0 [[207, 497]] 1.0 8r7g Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 8R7GB Q04771 205 498 509.0 YEE:501 Type1 Inactive DFGin 7.702 12.84 BLAminus -132.3, 173.86 64.56, 82.91 -96.15, 22.56 312.11, 149.54 -62.02, -22.37 in-out in 8.118 Saltbr-out 3.902 HRD-in -80.65, -58.3 79.92, 2.55 out-in-out SNCoio in-out ActLoopNT-in 2.903 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -108.9, 170.94 APE9-dihe-na -68.07, 167.85 APE8-dihe-in -62.36, 121.37 APE8-rot-in 303.04 APE67-dihe-in -62.81, -26.45 -65.67, -29.35 APE12-dist-in 10.843 APE11-dist-out 7.472 APE10-dist-out 9.043 APE9-dist-in 4.083 Q207D None None XRAY 2.09 0.228 0.253 B 301 293 1 0 0 0 [[207, 497]] 1.0 8r7g Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 8R7GD Q04771 204 498 509.0 YEE:501 Type1 Inactive DFGin 7.656 12.786 BLAminus -130.9, 171.35 64.69, 82.55 -97.53, 20.28 313.61, 165.44 -62.7, -21.28 in-none in 8.092 Saltbr-none 999.0 HRD-in -80.62, -57.63 79.17, 3.62 none-in-out SNCnio in-out ActLoopNT-in 2.934 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -131.29, 164.75 APE9-dihe-na -65.63, 171.5 APE8-dihe-in -60.25, 124.44 APE8-rot-in 310.83 APE67-dihe-in -65.19, -26.25 -64.07, -29.53 APE12-dist-in 10.404 APE11-dist-out 7.022 APE10-dist-out 8.812 APE9-dist-in 3.875 Q207D None None XRAY 2.09 0.228 0.253 D 301 291 4 0 0 4 [[207, 497]] 1.0 8r7g Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 9D8FA Q04771 193 499 509.0 A1A3C:608 Type1 Inactive DFGin 7.319 13.378 BLAminus -128.66, 164.64 72.87, 86.41 -100.74, 20.77 306.08, 179.38 -70.71, -15.71 in-out in 9.123 Saltbr-out 5.266 HRD-in -77.6, -50.3 78.68, -1.87 out-in-in SNCoii in-in ActLoopNT-in 2.998 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -95.63, -21.01 APE9-dihe-na -90.14, -153.44 APE8-dihe-in -88.84, 122.95 APE8-rot-in 297.07 APE67-dihe-in -54.58, -31.52 -56.69, -42.93 APE12-dist-in 11.791 APE11-dist-in 12.192 APE10-dist-in 6.259 APE9-dist-in 3.789 None None None XRAY 1.86 0.187 0.223 A 317 307 0 0 0 0 [[207, 497]] 1.0 9d8f Homo sapiens TKL_ACVR1_HUMAN TKL 2.2e-85 292.3 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 9D8FB Q04771 200 499 509.0 A1A3C:606 Type1 Inactive DFGin 7.398 13.213 BLAminus -125.37, 164.88 73.85, 83.9 -100.55, 21.31 302.03, 2.88 -74.3, -19.34 in-out in 8.893 Saltbr-out 5.062 HRD-in -75.68, -49.36 71.42, 0.82 out-in-in SNCoii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -90.91, 161.07 APE9-dihe-na 99.85, -170.3 APE8-dihe-in -94.7, 121.59 APE8-rot-in 300.47 APE67-dihe-in -54.39, -30.52 -51.8, -45.77 APE12-dist-in 11.878 APE11-dist-in 12.499 APE10-dist-in 6.442 APE9-dist-in 3.891 None None None XRAY 1.86 0.187 0.223 B 317 300 0 0 0 0 [[207, 497]] 1.0 9d8f Homo sapiens TKL_ACVR1_HUMAN TKL 2.2e-85 292.3 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 8UWRA Q04771 203 499 509.0 XQX:1007 Type1 Inactive DFGin 7.663 12.998 BLAminus -113.6, -176.93 71.58, 63.25 -92.75, 22.04 315.88, 3.12 -61.86, -28.81 in-out in 9.066 Saltbr-out 4.698 HRD-in -80.27, -50.42 75.31, 12.27 out-in-out SNCoio in-out ActLoopNT-in 2.788 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -115.11, 172.35 APE9-dihe-na -50.98, 178.62 APE8-dihe-in -78.55, 133.54 APE8-rot-in 298.31 APE67-dihe-in -49.27, -34.62 -72.69, -44.99 APE12-dist-in 10.693 APE11-dist-out 6.773 APE10-dist-out 8.709 APE9-dist-in 3.818 Q207D None None XRAY 2.04 0.214 0.281 A 323 297 0 0 0 0 [[207, 497]] 1.0 8uwr Homo sapiens TKL_ACVR1_HUMAN TKL 2.5e-85 292.2 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 3H9RA Q04771 172 499 509.0 TAK:1 Type1 Inactive DFGin 7.518 13.014 BLAminus -122.25, 172.9 70.66, 76.36 -93.47, 23.87 309.45, 171.73 -63.2, -18.75 in-out in 8.451 Saltbr-out 4.425 HRD-in -86.19, -50.58 71.93, 4.62 out-in-out SNCoio in-out ActLoopNT-in 2.955 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -141.78, 171.85 APE9-dihe-na -47.59, 161.63 APE8-dihe-in -64.93, 129.41 APE8-rot-in 303.28 APE67-dihe-in -52.25, -29.45 -62.04, -44.48 APE12-dist-none 999.0 APE11-dist-out 6.953 APE10-dist-out 8.669 APE9-dist-in 3.713 None None None XRAY 2.35 0.187 0.256 A 330 312 16 0 0 13 [[207, 497]] 1.0 3h9r Homo sapiens TKL_ACVR1_HUMAN TKL 2.6e-85 292.1 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 4C02A Q04771 178 499 509.0 TAK:1507 Type1 Inactive DFGin 7.528 12.943 BLAminus -123.21, 176.23 69.71, 70.69 -93.29, 15.04 304.56, 179.92 -66.52, -15.92 in-out in 8.69 Saltbr-out 4.668 HRD-in -78.82, -50.72 79.56, 2.7 out-in-in SNCoii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -100.38, -27.16 APE9-dihe-na -78.85, -155.95 APE8-dihe-in -85.96, 128.83 APE8-rot-in 303.97 APE67-dihe-in -57.18, -27.24 -62.7, -42.91 APE12-dist-in 12.293 APE11-dist-in 12.134 APE10-dist-in 6.189 APE9-dist-in 3.597 None None None XRAY 2.17 0.178 0.198 A 330 313 5 0 0 3 [[207, 497]] 1.0 4c02 Homo sapiens TKL_ACVR1_HUMAN TKL 2.6e-85 292.1 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6I1SA Q04771 172 499 509.0 E26:60501 Type1 Inactive DFGin 7.265 13.104 BLAminus -124.43, 167.68 73.9, 86.48 -100.59, 21.04 307.07, 1.66 -69.49, -17.73 in-out in 8.592 Saltbr-out 4.99 HRD-in -80.83, -53.14 79.1, -3.5 out-in-out SNCoio in-out ActLoopNT-in 2.927 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.74, 165.26 APE9-dihe-na -62.48, 165.28 APE8-dihe-in -62.22, 125.14 APE8-rot-in 300.67 APE67-dihe-in -57.23, -27.57 -60.91, -40.83 APE12-dist-in 10.361 APE11-dist-out 6.208 APE10-dist-out 9.062 APE9-dist-in 3.799 None None None XRAY 1.52 0.177 0.193 A 330 320 3 0 0 0 [[207, 497]] 1.0 6i1s Homo sapiens TKL_ACVR1_HUMAN TKL 2.6e-85 292.1 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 9D8EA Q04771 193 499 509.0 A1A29:703 Type1 Inactive DFGin 7.382 13.329 BLAminus -126.65, 164.15 70.79, 84.87 -98.58, 18.71 305.74, 179.57 -69.37, -18.79 in-out in 9.13 Saltbr-out 4.978 HRD-in -75.96, -48.11 74.25, -2.76 out-in-in SNCoii in-in ActLoopNT-in 2.872 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -95.78, -21.58 APE9-dihe-na -90.92, -141.42 APE8-dihe-in -99.59, 122.26 APE8-rot-in 299.69 APE67-dihe-in -58.11, -27.93 -57.36, -41.17 APE12-dist-in 11.729 APE11-dist-in 12.251 APE10-dist-in 6.291 APE9-dist-in 3.835 None None None XRAY 1.72 0.192 0.215 A 330 307 0 0 0 0 [[207, 497]] 1.0 9d8e Homo sapiens TKL_ACVR1_HUMAN TKL 2.6e-85 292.1 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 9D8EB Q04771 193 498 509.0 A1A29:501 Type1 Inactive DFGin 7.488 13.211 BLAminus -125.78, 165.64 71.99, 85.49 -102.71, 20.66 303.4, 179.67 -73.83, -20.49 in-out in 8.922 Saltbr-out 4.969 HRD-in -75.14, -48.46 72.82, -0.2 out-in-in SNCoii in-in ActLoopNT-in 2.808 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -98.27, -24.55 APE9-dihe-na -80.6, -148.51 APE8-dihe-in -94.26, 124.81 APE8-rot-in 298.35 APE67-dihe-in -52.79, -30.62 -58.26, -44.61 APE12-dist-in 12.424 APE11-dist-in 12.379 APE10-dist-in 6.408 APE9-dist-in 3.823 None None None XRAY 1.72 0.192 0.215 B 330 306 0 0 0 0 [[207, 497]] 1.0 9d8e Homo sapiens TKL_ACVR1_HUMAN TKL 2.6e-85 292.1 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 9RDAA Q04771 172 498 509.0 A1JFB:60501 Type1 Inactive DFGin 7.149 13.354 BLAminus -120.05, 170.69 71.22, 87.8 -102.97, 21.72 293.91, 179.06 -69.95, -15.99 in-in in 8.666 Saltbr-in 2.713 HRD-in -84.22, -53.25 81.1, -4.12 in-in-out SNCiio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.83, 166.35 APE9-dihe-na -61.6, 166.43 APE8-dihe-in -66.45, 126.88 APE8-rot-in 299.97 APE67-dihe-in -55.55, -28.43 -54.54, -47.13 APE12-dist-in 10.371 APE11-dist-out 6.199 APE10-dist-out 9.069 APE9-dist-in 3.796 None None None XRAY 1.748 0.195 0.224 A 330 318 4 0 0 0 [[207, 497]] 1.0 9rda Homo sapiens TKL_ACVR1_HUMAN TKL 2.6e-85 292.1 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 9D8ZA Q04771 203 499 509.0 A1A3D:600 Type1 Inactive DFGin 7.3 13.256 BLAminus -126.41, 165.94 76.26, 83.89 -99.24, 19.19 298.52, 8.39 -72.77, -19.83 in-out in 8.907 Saltbr-out 5.116 HRD-in -79.25, -49.91 75.06, -1.44 out-in-in SNCoii in-in ActLoopNT-in 2.873 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -100.72, -28.37 APE9-dihe-na -75.53, -154.22 APE8-dihe-in -89.92, 122.57 APE8-rot-in 298.44 APE67-dihe-in -58.34, -27.86 -55.41, -41.19 APE12-dist-in 11.918 APE11-dist-in 12.399 APE10-dist-in 6.418 APE9-dist-in 3.791 None None None XRAY 1.85 0.19 0.223 A 332 297 0 0 0 0 [[207, 497]] 1.0 9d8z Homo sapiens TKL_ACVR1_HUMAN TKL 2.7e-85 292.1 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 9D8ZB Q04771 193 499 509.0 A1A3D:600 Type1 Inactive DFGin 7.222 13.356 BLAminus -127.23, 166.36 73.43, 87.62 -100.88, 19.83 305.62, 0.23 -71.22, -15.61 in-out in 9.127 Saltbr-out 5.28 HRD-in -78.78, -47.38 76.09, -4.59 out-in-in SNCoii in-in ActLoopNT-in 3.015 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -91.25, -21.49 APE9-dihe-na -85.77, -158.58 APE8-dihe-in -85.31, 123.28 APE8-rot-in 302.29 APE67-dihe-in -60.96, -29.24 -58.86, -37.28 APE12-dist-in 11.753 APE11-dist-in 12.19 APE10-dist-in 6.198 APE9-dist-in 3.795 None None None XRAY 1.85 0.19 0.223 B 332 307 0 0 0 0 [[207, 497]] 1.0 9d8z Homo sapiens TKL_ACVR1_HUMAN TKL 2.7e-85 292.1 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6UNSA Q04771 204 496 509.0 LDN:501 Type1 Inactive DFGin 7.224 12.856 BLAminus -117.56, 173.67 72.35, 88.75 -102.95, 22.4 297.93, 174.62 -66.2, -23.82 in-in in 8.105 Saltbr-in 2.98 HRD-in -81.6, -59.03 82.63, -0.45 in-in-out SNCiio in-out ActLoopNT-in 2.813 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -93.62, 142.8 APE9-dihe-na -63.9, 171.12 APE8-dihe-in -66.39, 123.82 APE8-rot-in 304.97 APE67-dihe-in -58.01, -31.11 -66.21, -35.39 APE12-dist-in 10.492 APE11-dist-out 6.558 APE10-dist-out 10.005 APE9-dist-in 4.508 K492A,K493A None None XRAY 2.3 0.215 0.262 A 330 288 6 0 0 0 [[207, 497]] 1.0 6uns Homo sapiens TKL_ACVR1_HUMAN TKL 7.3e-85 290.8 2 266 265 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6UNSB Q04771 204 496 509.0 LDN:501 Type1 Inactive DFGin 7.709 12.736 BLAminus -118.56, 173.66 72.39, 85.71 -105.41, 24.1 306.63, 13.91 -67.87, -22.75 in-out in 8.235 Saltbr-out 3.878 HRD-in -80.19, -57.75 81.06, 0.8 out-in-out SNCoio in-out ActLoopNT-in 2.772 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -97.69, 138.7 APE9-dihe-na -64.83, 170.36 APE8-dihe-in -65.69, 123.25 APE8-rot-in 313.39 APE67-dihe-in -58.4, -31.45 -67.8, -32.39 APE12-dist-in 10.479 APE11-dist-out 6.408 APE10-dist-out 9.87 APE9-dist-in 4.562 K492A,K493A None None XRAY 2.3 0.215 0.262 B 330 290 4 0 0 0 [[207, 497]] 1.0 6uns Homo sapiens TKL_ACVR1_HUMAN TKL 7.3e-85 290.8 2 266 265 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6EIXA Q04771 192 503 509.0 A3F:601 Type1 Inactive DFGin 7.305 13.382 BLAminus -122.31, 163.89 74.01, 85.68 -98.53, 23.31 310.02, 174.96 -66.89, -23.04 in-out in 9.083 Saltbr-out 5.16 HRD-in -81.6, -53.66 78.97, -2.54 out-in-out SNCoio in-out ActLoopNT-in 3.023 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -113.45, 165.41 APE9-dihe-na -59.94, 163.8 APE8-dihe-in -59.76, 126.51 APE8-rot-in 307.55 APE67-dihe-in -58.05, -30.26 -58.58, -41.78 APE12-dist-in 10.589 APE11-dist-out 6.415 APE10-dist-out 9.311 APE9-dist-in 3.871 Q207E None None XRAY 2.3 0.191 0.249 A 340 312 0 0 0 0 [[207, 497]] 1.0 6eix Homo sapiens TKL_ACVR1_HUMAN TKL 2.9e-85 292.0 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7BB Q04771 205 499 509.0 LU8:501,XH7:506 Type1,Allosteric Inactive DFGin 7.021 13.362 BLAminus -121.46, 161.83 78.44, 88.34 -102.47, 19.49 301.42, 173.88 -65.45, -20.59 in-out in 8.79 Saltbr-out 4.685 HRD-in -74.99, -55.16 78.67, -0.58 out-in-out SNCoio in-out ActLoopNT-in 2.913 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.52, 156.89 APE9-dihe-na -51.95, 170.55 APE8-dihe-in -69.31, 128.28 APE8-rot-in 299.94 APE67-dihe-in -63.25, -25.99 -60.99, -39.27 APE12-dist-in 10.404 APE11-dist-out 6.393 APE10-dist-out 9.095 APE9-dist-in 3.807 Q207D None None XRAY 1.32 0.169 0.195 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s7b Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7CB Q04771 205 499 509.0 LU8:501,T5Y:505 Type1,Allosteric Inactive DFGin 7.062 13.389 BLAminus -126.3, 161.98 79.71, 89.61 -103.06, 23.5 302.55, 173.63 -67.99, -21.1 in-out in 8.854 Saltbr-out 4.758 HRD-in -77.43, -53.45 76.82, -0.13 out-in-out SNCoio in-out ActLoopNT-in 2.913 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.01, 166.06 APE9-dihe-na -60.91, 165.47 APE8-dihe-in -62.27, 130.39 APE8-rot-in 299.14 APE67-dihe-in -63.71, -26.19 -64.69, -37.05 APE12-dist-in 10.364 APE11-dist-out 6.238 APE10-dist-out 8.994 APE9-dist-in 3.938 Q207D None None XRAY 1.31 0.161 0.179 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s7c Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7DB Q04771 205 499 509.0 LU8:501,XHD:505 Type1,Allosteric Inactive DFGin 7.0 13.349 BLAminus -123.42, 163.32 74.65, 90.04 -104.07, 23.56 302.54, 177.54 -72.51, -12.63 in-out in 8.759 Saltbr-out 4.702 HRD-in -77.61, -53.61 80.79, -1.13 out-in-out SNCoio in-out ActLoopNT-in 2.969 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.29, 164.81 APE9-dihe-na -57.91, 162.72 APE8-dihe-in -60.44, 129.2 APE8-rot-in 299.64 APE67-dihe-in -59.07, -29.49 -62.4, -40.3 APE12-dist-in 10.358 APE11-dist-out 6.219 APE10-dist-out 9.026 APE9-dist-in 3.786 Q207D None None XRAY 1.31 0.165 0.185 B 301 295 0 0 0 0 [[207, 497]] 1.0 5s7d Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7EB Q04771 205 499 509.0 LU8:501,XEA:505 Type1,Allosteric Inactive DFGin 7.001 13.456 BLAminus -126.91, 163.64 73.07, 91.25 -103.42, 21.63 301.95, 174.37 -67.85, -18.9 in-out in 8.813 Saltbr-out 4.722 HRD-in -77.73, -53.3 79.65, -3.06 out-in-out SNCoio in-out ActLoopNT-in 2.929 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -117.66, 166.82 APE9-dihe-na -61.55, 164.95 APE8-dihe-in -59.98, 129.55 APE8-rot-in 299.19 APE67-dihe-in -58.01, -29.13 -63.05, -41.4 APE12-dist-in 10.258 APE11-dist-out 6.215 APE10-dist-out 9.008 APE9-dist-in 3.801 Q207D None None XRAY 1.32 0.168 0.189 B 301 293 2 0 0 0 [[207, 497]] 1.0 5s7e Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7KB Q04771 205 499 509.0 LU8:501,XEJ:504 Type1,Allosteric Inactive DFGin 6.981 13.27 BLAminus -124.3, 164.86 75.9, 87.47 -102.78, 21.12 305.49, 0.35 -65.97, -18.91 in-out in 8.834 Saltbr-out 4.647 HRD-in -79.74, -53.13 79.6, -2.25 out-in-out SNCoio in-out ActLoopNT-in 2.859 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.28, 163.22 APE9-dihe-na -60.14, 169.9 APE8-dihe-in -64.39, 127.18 APE8-rot-in 298.46 APE67-dihe-in -57.76, -29.28 -59.11, -42.6 APE12-dist-in 10.421 APE11-dist-out 6.301 APE10-dist-out 8.974 APE9-dist-in 3.677 None None None XRAY 1.31 0.162 0.188 B 301 293 2 0 0 0 [[207, 497]] 1.0 5s7k Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7MB Q04771 208 499 509.0 LU8:501,HVK:505 Type1,Allosteric Inactive DFGin 7.009 13.321 BLAminus -124.89, 160.91 76.23, 87.23 -100.03, 22.28 300.52, 174.89 -68.18, -14.07 in-out in 8.451 Saltbr-out 4.202 HRD-in -76.72, -54.96 80.02, -2.85 out-in-out SNCoio in-out ActLoopNT-in 2.924 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.58, 168.17 APE9-dihe-na -62.95, 162.95 APE8-dihe-in -58.04, 127.45 APE8-rot-in 298.56 APE67-dihe-in -59.18, -25.23 -62.3, -40.69 APE12-dist-in 10.37 APE11-dist-out 6.21 APE10-dist-out 8.938 APE9-dist-in 3.814 Q207D None None XRAY 1.32 0.171 0.195 B 301 290 2 0 0 0 [[207, 497]] 1.0 5s7m Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7NB Q04771 207 499 509.0 LU8:501,2AI:505 Type1,Allosteric Inactive DFGin 7.005 13.42 BLAminus -126.13, 161.61 77.78, 88.49 -101.78, 20.71 303.39, 175.45 -67.06, -19.53 in-out in 8.86 Saltbr-out 4.716 HRD-in -78.53, -54.27 81.6, -6.08 out-in-out SNCoio in-out ActLoopNT-in 2.957 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.2, 164.62 APE9-dihe-na -57.6, 161.75 APE8-dihe-in -58.85, 126.75 APE8-rot-in 300.18 APE67-dihe-in -61.19, -26.66 -59.93, -40.36 APE12-dist-in 10.27 APE11-dist-out 6.151 APE10-dist-out 9.007 APE9-dist-in 3.756 Q207D None None XRAY 1.3 0.163 0.186 B 301 290 3 0 0 0 [[207, 497]] 1.0 5s7n Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7SB Q04771 205 499 509.0 LU8:501,09V:505 Type1,Allosteric Inactive DFGin 6.987 13.406 BLAminus -127.22, 162.49 75.55, 89.77 -103.58, 21.52 302.17, 178.46 -71.16, -15.05 in-out in 8.879 Saltbr-out 4.766 HRD-in -78.6, -54.23 80.1, -1.5 out-in-out SNCoio in-out ActLoopNT-in 2.925 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.31, 165.17 APE9-dihe-na -61.08, 163.96 APE8-dihe-in -59.96, 128.29 APE8-rot-in 298.36 APE67-dihe-in -59.32, -26.33 -61.06, -42.91 APE12-dist-in 10.26 APE11-dist-out 6.189 APE10-dist-out 9.019 APE9-dist-in 3.778 Q207D None None XRAY 1.3 0.153 0.171 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s7s Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7VB Q04771 205 499 509.0 LU8:501,XH1:505 Type1,Allosteric Inactive DFGin 7.014 13.512 BLAminus -126.76, 162.04 76.91, 90.47 -102.68, 21.03 302.06, 175.32 -69.9, -15.12 in-out in 8.929 Saltbr-out 4.79 HRD-in -78.61, -53.05 79.7, -1.04 out-in-out SNCoio in-out ActLoopNT-in 2.927 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.43, 165.76 APE9-dihe-na -60.04, 163.83 APE8-dihe-in -61.01, 129.39 APE8-rot-in 297.49 APE67-dihe-in -59.56, -27.34 -62.0, -41.39 APE12-dist-in 10.293 APE11-dist-out 6.183 APE10-dist-out 9.005 APE9-dist-in 3.852 Q207D None None XRAY 1.31 0.154 0.172 B 301 291 4 0 0 0 [[207, 497]] 1.0 5s7v Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7XB Q04771 205 499 509.0 LU8:501,LGA:505 Type1,Allosteric Inactive DFGin 7.031 13.379 BLAminus -128.0, 163.2 78.06, 89.3 -102.46, 20.69 301.92, 175.18 -69.56, -15.46 in-out in 8.827 Saltbr-out 4.64 HRD-in -76.89, -56.14 80.13, -1.68 out-in-out SNCoio in-out ActLoopNT-in 2.919 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.04, 166.03 APE9-dihe-na -61.79, 165.52 APE8-dihe-in -59.06, 127.18 APE8-rot-in 299.22 APE67-dihe-in -59.1, -28.73 -61.83, -40.56 APE12-dist-in 10.378 APE11-dist-out 6.165 APE10-dist-out 8.945 APE9-dist-in 3.807 Q207D None None XRAY 1.3 0.151 0.169 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s7x Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7ZB Q04771 205 499 509.0 LU8:501,BYZ:505 Type1,Allosteric Inactive DFGin 6.963 13.374 BLAminus -125.8, 161.65 77.14, 88.32 -102.44, 23.35 302.89, 177.91 -73.03, -13.12 in-out in 8.771 Saltbr-out 4.721 HRD-in -76.79, -54.43 80.82, -3.64 out-in-out SNCoio in-out ActLoopNT-in 2.92 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.61, 165.38 APE9-dihe-na -60.57, 163.68 APE8-dihe-in -58.84, 127.79 APE8-rot-in 300.37 APE67-dihe-in -58.11, -27.66 -62.19, -41.34 APE12-dist-in 10.351 APE11-dist-out 6.147 APE10-dist-out 9.002 APE9-dist-in 3.837 Q207D None None XRAY 1.3 0.163 0.184 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s7z Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S82B Q04771 205 499 509.0 LU8:501,LAC:505 Type1,Allosteric Inactive DFGin 6.655 13.398 BLAminus -126.04, 165.16 75.17, 84.42 -92.96, 20.32 298.14, 1.79 -72.8, -17.41 in-out in 8.905 Saltbr-out 4.497 HRD-in -74.85, -51.79 76.63, 2.28 out-in-in SNCoii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.55, 160.28 APE9-dihe-na 116.12, -172.15 APE8-dihe-in -92.31, 127.42 APE8-rot-in 312.53 APE67-dihe-in -58.12, -32.21 -55.48, -45.17 APE12-dist-in 11.377 APE11-dist-in 12.104 APE10-dist-in 6.253 APE9-dist-in 3.792 Q207D None None XRAY 1.71 0.211 0.253 B 301 284 11 0 0 7 [[207, 497]] 1.0 5s82 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S86B Q04771 205 499 509.0 LU8:501,XK7:505 Type1,Allosteric Inactive DFGin 7.0 13.343 BLAminus -124.78, 165.07 76.1, 88.35 -101.51, 22.18 301.71, 177.78 -69.78, -18.41 in-out in 8.888 Saltbr-out 4.745 HRD-in -81.45, -50.76 76.49, -0.86 out-in-in SNCoii in-in ActLoopNT-in 2.931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.0, 158.9 APE9-dihe-na 111.5, 158.23 APE8-dihe-in -70.2, 127.65 APE8-rot-in 298.18 APE67-dihe-in -59.26, -28.16 -59.39, -41.48 APE12-dist-in 11.628 APE11-dist-in 12.218 APE10-dist-in 6.671 APE9-dist-in 3.687 Q207D None None XRAY 1.31 0.169 0.19 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s86 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S87B Q04771 205 499 509.0 LU8:501,XKD:505 Type1,Allosteric Inactive DFGin 6.965 13.387 BLAminus -125.7, 164.87 74.71, 88.13 -101.5, 22.91 303.75, 177.62 -68.86, -17.71 in-out in 8.833 Saltbr-out 4.749 HRD-in -82.36, -52.31 79.91, -1.72 out-in-out SNCoio in-out ActLoopNT-in 2.92 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.25, 165.32 APE9-dihe-na -62.4, 164.8 APE8-dihe-in -61.06, 127.57 APE8-rot-in 297.97 APE67-dihe-in -58.73, -29.86 -59.37, -42.06 APE12-dist-in 10.243 APE11-dist-out 6.173 APE10-dist-out 8.969 APE9-dist-in 3.679 Q207D None None XRAY 1.3 0.161 0.181 B 301 290 5 0 0 0 [[207, 497]] 1.0 5s87 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S88B Q04771 205 499 509.0 LU8:501,XKS:505 Type1,Allosteric Inactive DFGin 6.973 13.376 BLAminus -122.04, 163.88 74.1, 88.2 -100.76, 18.77 302.29, 178.38 -66.87, -16.44 in-out in 8.871 Saltbr-out 4.722 HRD-in -80.9, -52.59 78.53, -3.8 out-in-out SNCoio in-out ActLoopNT-in 2.94 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.43, 164.81 APE9-dihe-na -62.32, 166.78 APE8-dihe-in -60.75, 128.44 APE8-rot-in 298.57 APE67-dihe-in -57.52, -28.98 -62.58, -40.65 APE12-dist-in 10.33 APE11-dist-out 6.149 APE10-dist-out 9.027 APE9-dist-in 3.708 Q207D None None XRAY 1.31 0.16 0.179 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s88 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S8AB Q04771 205 499 509.0 LU8:501,XKY:505 Type1,Allosteric Inactive DFGin 6.955 13.337 BLAminus -125.42, 163.04 76.47, 86.69 -100.25, 21.43 305.15, 178.88 -67.55, -16.71 in-out in 8.827 Saltbr-out 4.678 HRD-in -78.68, -54.41 80.9, -2.81 out-in-out SNCoio in-out ActLoopNT-in 2.938 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -117.78, 163.73 APE9-dihe-na -58.28, 164.12 APE8-dihe-in -61.01, 126.61 APE8-rot-in 297.82 APE67-dihe-in -58.41, -30.66 -59.54, -41.22 APE12-dist-in 10.24 APE11-dist-out 6.117 APE10-dist-out 9.04 APE9-dist-in 3.776 Q207D None None XRAY 1.3 0.158 0.179 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s8a Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 8PODA Q04771 172 498 509.0 7IO:60501,F:60502 Type1,Allosteric Inactive DFGin 7.181 13.248 BLAminus -129.23, 172.96 64.95, 88.23 -102.11, 21.22 307.17, 178.99 -69.46, -24.05 in-out in 8.75 Saltbr-out 5.24 HRD-in -77.46, -49.01 73.0, -1.63 out-in-out SNCoio in-out ActLoopNT-in 3.105 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -104.74, 151.99 APE9-dihe-na -69.89, 170.49 APE8-dihe-in -67.7, 124.46 APE8-rot-in 304.29 APE67-dihe-in -63.94, -28.35 -69.6, -32.91 APE12-dist-in 10.74 APE11-dist-out 6.542 APE10-dist-out 9.732 APE9-dist-in 4.647 None None None XRAY 2.59 0.236 0.255 A 330 320 1 0 0 0 [[207, 497]] 1.0 8pod Homo sapiens TKL_ACVR1_HUMAN TKL 2.6e-85 292.1 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S75B Q04771 205 499 509.0 LU8:501,HUH:505,HUH:506 Type1,Allosteric,Allosteric Inactive DFGin 7.043 13.384 BLAminus -125.56, 161.73 76.89, 90.9 -104.0, 22.37 302.45, 178.35 -68.36, -16.58 in-out in 8.803 Saltbr-out 4.754 HRD-in -77.19, -54.35 79.9, -2.77 out-in-out SNCoio in-out ActLoopNT-in 2.925 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.92, 165.96 APE9-dihe-na -62.98, 165.92 APE8-dihe-in -61.22, 127.2 APE8-rot-in 298.98 APE67-dihe-in -59.47, -28.54 -61.97, -40.32 APE12-dist-in 10.373 APE11-dist-out 6.193 APE10-dist-out 8.992 APE9-dist-in 3.778 Q207D None None XRAY 1.3 0.156 0.173 B 301 293 2 0 0 0 [[207, 497]] 1.0 5s75 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S79A Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.359 13.307 BLAminus -117.94, 162.46 74.88, 92.31 -102.33, 24.3 297.49, 0.79 -68.18, -20.94 in-out in 9.093 Saltbr-out 5.852 HRD-in -74.67, -52.38 75.13, 0.8 out-in-out SNCoio in-out ActLoopNT-in 2.923 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -130.7, 172.52 APE9-dihe-na -62.7, 161.48 APE8-dihe-in -63.27, 127.15 APE8-rot-in 306.54 APE67-dihe-in -57.17, -31.15 -61.23, -39.7 APE12-dist-none 999.0 APE11-dist-out 6.376 APE10-dist-out 8.755 APE9-dist-in 3.742 Q207D None None XRAY 1.5 0.18 0.206 A 301 284 14 0 0 12 [[207, 497]] 1.0 5s79 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7AB Q04771 205 499 509.0 LU8:501,T5V:505,T5V:506 Type1,Allosteric,Allosteric Inactive DFGin 7.039 13.38 BLAminus -126.41, 163.07 76.94, 87.35 -100.8, 22.69 302.52, 175.53 -70.21, -15.13 in-out in 8.793 Saltbr-out 4.721 HRD-in -77.59, -56.91 81.94, -2.79 out-in-out SNCoio in-out ActLoopNT-in 2.931 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.27, 167.32 APE9-dihe-na -61.57, 164.52 APE8-dihe-in -61.32, 127.79 APE8-rot-in 299.15 APE67-dihe-in -59.77, -26.87 -62.23, -39.78 APE12-dist-in 10.33 APE11-dist-out 6.233 APE10-dist-out 8.98 APE9-dist-in 3.833 Q207D None None XRAY 1.3 0.16 0.18 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s7a Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7EA Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509 Type1,Allosteric,Allosteric Inactive DFGin 8.379 13.303 BLAminus -121.44, 162.36 74.46, 91.44 -103.29, 27.05 299.26, 176.52 -69.12, -17.65 in-out in 9.178 Saltbr-out 6.106 HRD-in -79.8, -52.73 76.32, 0.43 out-in-out SNCoio in-out ActLoopNT-in 2.886 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -122.76, 172.59 APE9-dihe-na -57.54, 160.03 APE8-dihe-in -61.32, 126.08 APE8-rot-in 304.6 APE67-dihe-in -53.51, -32.05 -63.31, -40.67 APE12-dist-none 999.0 APE11-dist-out 6.308 APE10-dist-out 8.841 APE9-dist-in 3.714 Q207D None None XRAY 1.32 0.168 0.189 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s7e Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7FA Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509 Type1,Allosteric,Allosteric Inactive DFGin 8.369 13.32 BLAminus -122.11, 160.49 78.65, 89.18 -101.96, 26.72 301.12, 175.97 -69.09, -20.41 in-out in 9.101 Saltbr-out 6.107 HRD-in -78.16, -52.77 77.11, -0.2 out-in-out SNCoio in-out ActLoopNT-in 2.917 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -124.41, 172.12 APE9-dihe-na -64.48, 163.27 APE8-dihe-in -60.82, 122.78 APE8-rot-in 304.26 APE67-dihe-in -57.8, -32.72 -63.43, -34.75 APE12-dist-none 999.0 APE11-dist-out 6.233 APE10-dist-out 8.851 APE9-dist-in 3.675 Q207D None None XRAY 1.31 0.151 0.169 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s7f Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7FB Q04771 205 499 509.0 LU8:501,XH4:505,XH4:506 Type1,Allosteric,Allosteric Inactive DFGin 7.004 13.386 BLAminus -125.15, 160.98 75.58, 90.9 -103.26, 20.62 302.27, 174.02 -66.35, -18.49 in-out in 8.851 Saltbr-out 4.768 HRD-in -78.67, -52.91 79.11, -3.95 out-in-out SNCoio in-out ActLoopNT-in 2.919 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.71, 164.43 APE9-dihe-na -63.66, 165.2 APE8-dihe-in -60.32, 128.18 APE8-rot-in 298.19 APE67-dihe-in -60.19, -25.76 -61.92, -39.78 APE12-dist-in 10.345 APE11-dist-out 6.114 APE10-dist-out 9.042 APE9-dist-in 3.828 Q207D None None XRAY 1.31 0.151 0.169 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s7f Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7GA Q04771 202 498 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.499 13.329 BLAminus -125.16, 165.77 74.59, 86.92 -99.45, 20.56 296.92, 176.9 -55.21, -25.24 in-out in 9.329 Saltbr-out 5.788 HRD-in -78.53, -53.51 74.34, 2.0 out-in-none SNCoin in-none ActLoopNT-in 2.902 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -116.42, 161.19 APE9-dihe-na 107.2, -168.38 APE8-dihe-in -91.58, 123.63 APE8-rot-in 309.25 APE67-dihe-in -59.99, -30.06 -55.11, -41.51 APE12-dist-none 999.0 APE11-dist-in 10.366 APE10-dist-in 6.423 APE9-dist-in 3.906 Q207D None None XRAY 1.78 0.206 0.252 A 301 284 13 0 0 13 [[207, 497]] 1.0 5s7g Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7OA Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.291 13.421 BLAminus -118.75, 163.36 74.89, 87.72 -99.53, 25.84 300.09, 2.07 -68.13, -17.89 in-out in 9.207 Saltbr-out 6.197 HRD-in -76.07, -55.9 78.85, -1.81 out-in-out SNCoio in-out ActLoopNT-in 2.914 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -124.0, 170.72 APE9-dihe-na -63.29, 163.84 APE8-dihe-in -60.21, 123.9 APE8-rot-in 304.44 APE67-dihe-in -59.71, -29.26 -62.37, -36.73 APE12-dist-in 11.038 APE11-dist-out 6.038 APE10-dist-out 8.868 APE9-dist-in 3.643 Q207D None None XRAY 1.43 0.165 0.189 A 301 287 12 0 0 11 [[207, 497]] 1.0 5s7o Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7QA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.39 13.112 BLAminus -122.32, 165.01 69.61, 90.09 -98.74, 20.54 300.47, 4.84 -55.87, -28.73 in-out in 9.115 Saltbr-out 6.176 HRD-in -80.49, -54.34 80.36, -1.4 out-in-out SNCoio in-out ActLoopNT-in 2.933 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.26, 178.66 APE9-dihe-na -63.48, 166.31 APE8-dihe-in -61.68, 126.19 APE8-rot-in 310.31 APE67-dihe-in -52.14, -34.66 -61.41, -42.72 APE12-dist-none 999.0 APE11-dist-out 6.789 APE10-dist-out 8.89 APE9-dist-in 3.538 Q207D None None XRAY 1.53 0.209 0.243 A 301 282 16 0 0 13 [[207, 497]] 1.0 5s7q Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7UA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.305 13.213 BLAminus -114.05, 162.83 73.86, 86.44 -96.11, 24.11 301.91, 5.0 -63.32, -18.47 in-out in 9.223 Saltbr-out 5.669 HRD-in -78.6, -56.95 81.06, 1.88 out-in-none SNCoin in-none ActLoopNT-in 2.888 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -102.37, -33.42 APE9-dihe-na -82.13, -169.33 APE8-dihe-in -70.61, 128.02 APE8-rot-in 308.81 APE67-dihe-in -53.65, -30.76 -61.02, -43.28 APE12-dist-none 999.0 APE11-dist-in 10.904 APE10-dist-in 6.457 APE9-dist-in 3.654 Q207D None None XRAY 1.59 0.219 0.261 A 301 280 18 0 0 13 [[207, 497]] 1.0 5s7u Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7UB Q04771 205 499 509.0 LU8:501,XGY:505,XGY:506 Type1,Allosteric,Allosteric Inactive DFGin 6.697 13.354 BLAminus -130.21, 164.61 74.6, 82.7 -94.38, 13.73 305.4, 176.35 -55.24, -22.33 in-out in 8.956 Saltbr-out 4.687 HRD-in -75.48, -53.06 77.34, -3.38 out-in-out SNCoio in-out ActLoopNT-in 2.815 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -164.99, 129.38 APE9-dihe-na -126.69, -126.94 APE8-dihe-in -91.63, 124.43 APE8-rot-in 299.73 APE67-dihe-in -58.25, -31.07 -56.39, -48.22 APE12-dist-in 10.829 APE11-dist-in 11.47 APE10-dist-out 9.514 APE9-dist-in 4.03 Q207D None None XRAY 1.59 0.219 0.261 B 301 279 16 0 0 9 [[207, 497]] 1.0 5s7u Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7VA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.329 13.327 BLAminus -124.73, 163.23 77.04, 90.62 -101.21, 26.19 302.83, 177.61 -67.83, -17.56 in-out in 9.132 Saltbr-out 5.919 HRD-in -78.43, -52.77 77.91, -0.2 out-in-out SNCoio in-out ActLoopNT-in 2.93 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.42, 168.77 APE9-dihe-na -60.41, 164.86 APE8-dihe-in -63.38, 124.43 APE8-rot-in 302.99 APE67-dihe-in -57.33, -32.29 -63.57, -36.66 APE12-dist-none 999.0 APE11-dist-out 6.136 APE10-dist-out 8.877 APE9-dist-in 3.686 Q207D None None XRAY 1.31 0.154 0.172 A 301 282 16 0 0 12 [[207, 497]] 1.0 5s7v Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7WA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.382 13.422 BLAminus -120.63, 163.92 74.5, 89.95 -100.48, 28.03 301.03, 179.86 -70.31, -18.41 in-out in 9.243 Saltbr-out 6.201 HRD-in -78.77, -52.99 79.89, -3.2 out-in-out SNCoio in-out ActLoopNT-in 2.94 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -122.35, 170.12 APE9-dihe-na -61.34, 168.74 APE8-dihe-in -65.88, 124.22 APE8-rot-in 304.99 APE67-dihe-in -56.25, -29.94 -63.21, -38.79 APE12-dist-none 999.0 APE11-dist-out 6.253 APE10-dist-out 8.927 APE9-dist-in 3.696 Q207D None None XRAY 1.33 0.164 0.186 A 301 284 14 0 0 13 [[207, 497]] 1.0 5s7w Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7YA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.378 13.343 BLAminus -121.01, 162.15 74.22, 90.85 -101.18, 24.99 303.51, 176.94 -65.0, -19.5 in-out in 9.246 Saltbr-out 6.205 HRD-in -79.92, -53.25 77.89, -1.46 out-in-out SNCoio in-out ActLoopNT-in 2.903 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -125.05, 171.62 APE9-dihe-na -63.16, 165.02 APE8-dihe-in -61.65, 124.26 APE8-rot-in 302.58 APE67-dihe-in -56.65, -33.92 -63.4, -36.98 APE12-dist-none 999.0 APE11-dist-out 6.068 APE10-dist-out 8.872 APE9-dist-in 3.612 Q207D None None XRAY 1.37 0.161 0.184 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s7y Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S80A Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509 Type1,Allosteric,Allosteric Inactive DFGin 8.314 13.306 BLAminus -112.55, 159.81 78.34, 88.26 -99.06, 22.42 300.25, 0.46 -63.75, -19.98 in-out in 9.025 Saltbr-out 5.883 HRD-in -76.34, -54.31 74.73, 2.06 out-in-out SNCoio in-out ActLoopNT-in 2.906 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -128.9, 168.55 APE9-dihe-na -54.89, 157.92 APE8-dihe-in -57.52, 122.86 APE8-rot-in 308.47 APE67-dihe-in -52.78, -30.68 -62.36, -41.16 APE12-dist-none 999.0 APE11-dist-out 6.143 APE10-dist-out 8.783 APE9-dist-in 3.735 Q207D None None XRAY 1.67 0.197 0.231 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s80 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S80B Q04771 205 499 509.0 LU8:501,XGM:505,XGM:506 Type1,Allosteric,Allosteric Inactive DFGin 7.027 13.553 BLAminus -130.83, 163.29 75.8, 86.12 -98.93, 18.93 301.48, 172.59 -65.51, -18.83 in-out in 8.969 Saltbr-out 4.718 HRD-in -78.19, -55.2 81.16, -3.45 out-in-out SNCoio in-out ActLoopNT-in 2.855 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.24, 160.71 APE9-dihe-na -59.43, 165.2 APE8-dihe-in -58.98, 127.47 APE8-rot-in 308.35 APE67-dihe-in -58.04, -28.7 -56.74, -44.6 APE12-dist-in 10.41 APE11-dist-out 6.126 APE10-dist-out 9.086 APE9-dist-in 3.811 Q207D None None XRAY 1.67 0.197 0.231 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s80 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S82A Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.468 13.254 BLAminus -122.58, 165.4 75.09, 85.58 -98.64, 22.96 294.39, 0.35 -56.95, -25.74 in-out in 9.336 Saltbr-out 5.524 HRD-in -76.5, -58.03 77.63, 6.82 out-in-none SNCoin in-none ActLoopNT-in 2.859 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -106.37, 156.71 APE9-dihe-na 110.11, -167.89 APE8-dihe-in -91.26, 123.24 APE8-rot-in 309.79 APE67-dihe-in -54.4, -31.68 -54.65, -45.23 APE12-dist-none 999.0 APE11-dist-in 10.894 APE10-dist-in 6.436 APE9-dist-in 3.982 Q207D None None XRAY 1.71 0.211 0.253 A 301 279 19 0 0 13 [[207, 497]] 1.0 5s82 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S87A Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.356 13.334 BLAminus -124.64, 162.22 77.24, 89.92 -101.8, 26.16 301.34, 177.73 -70.64, -14.84 in-out in 9.288 Saltbr-out 6.074 HRD-in -77.97, -54.71 79.68, 0.35 out-in-out SNCoio in-out ActLoopNT-in 2.932 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -122.28, 171.55 APE9-dihe-na -60.97, 165.72 APE8-dihe-in -65.13, 123.33 APE8-rot-in 301.16 APE67-dihe-in -56.7, -32.97 -59.78, -39.02 APE12-dist-none 999.0 APE11-dist-out 6.246 APE10-dist-out 9.075 APE9-dist-in 3.564 Q207D None None XRAY 1.3 0.161 0.181 A 301 284 15 0 0 13 [[207, 497]] 1.0 5s87 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S88A Q04771 202 499 509.0 LU8:501,LU8:506,LU8:507 Type1,Allosteric,Allosteric Inactive DFGin 8.391 13.328 BLAminus -125.32, 162.15 75.36, 89.99 -102.31, 27.55 301.87, 179.45 -66.0, -20.71 in-out in 9.287 Saltbr-out 6.057 HRD-in -78.45, -54.06 78.95, -0.59 out-in-out SNCoio in-out ActLoopNT-in 2.938 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -122.53, 173.56 APE9-dihe-na -66.93, 166.27 APE8-dihe-in -60.51, 123.12 APE8-rot-in 301.13 APE67-dihe-in -58.29, -28.73 -59.87, -40.21 APE12-dist-none 999.0 APE11-dist-out 6.189 APE10-dist-out 8.979 APE9-dist-in 3.598 Q207D None None XRAY 1.31 0.16 0.179 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s88 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S9KA Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.352 13.35 BLAminus -119.09, 162.43 73.95, 91.92 -101.37, 24.48 300.38, 179.39 -71.09, -13.1 in-out in 9.313 Saltbr-out 6.159 HRD-in -79.72, -52.91 78.84, -1.65 out-in-out SNCoio in-out ActLoopNT-in 2.927 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -122.92, 173.99 APE9-dihe-na -63.97, 163.84 APE8-dihe-in -62.03, 121.91 APE8-rot-in 301.87 APE67-dihe-in -54.23, -35.11 -55.21, -43.69 APE12-dist-none 999.0 APE11-dist-out 6.38 APE10-dist-out 9.147 APE9-dist-in 3.522 Q207D None None XRAY 1.35 0.176 0.2 A 301 281 18 0 0 13 [[207, 497]] 1.0 5s9k Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6SRHB Q04771 205 499 509.0 LU8:501,LU8:502,LU8:503 Type1,Allosteric,Allosteric Inactive DFGin 6.936 13.392 BLAminus -126.84, 164.05 75.03, 87.93 -100.83, 18.93 301.99, 177.59 -71.89, -11.94 in-out in 8.912 Saltbr-out 4.747 HRD-in -80.94, -52.46 80.13, -0.8 out-in-out SNCoio in-out ActLoopNT-in 2.925 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.66, 165.78 APE9-dihe-na -63.94, 166.94 APE8-dihe-in -62.11, 128.55 APE8-rot-in 298.15 APE67-dihe-in -60.05, -27.13 -57.77, -43.71 APE12-dist-in 10.329 APE11-dist-out 6.122 APE10-dist-out 9.07 APE9-dist-in 3.808 Q207D None None XRAY 1.25 0.134 0.16 B 301 295 0 0 0 0 [[207, 497]] 1.0 6srh Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6Z36A Q04771 202 499 509.0 Q5Z:804,Q5Z:805,Q5Z:806 Type1,Allosteric,Allosteric Inactive DFGin 8.308 13.439 BLAminus -125.01, 162.69 76.21, 87.71 -99.86, 22.76 295.6, 176.41 -67.16, -18.78 in-out in 9.193 Saltbr-out 5.877 HRD-in -79.32, -51.72 78.28, -0.5 out-in-out SNCoio in-out ActLoopNT-in 2.906 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.37, 172.12 APE9-dihe-na -68.49, 169.45 APE8-dihe-in -67.68, 126.82 APE8-rot-in 301.86 APE67-dihe-in -56.95, -28.66 -61.7, -39.93 APE12-dist-none 999.0 APE11-dist-out 6.376 APE10-dist-out 8.941 APE9-dist-in 3.767 Q207D None None XRAY 1.37 0.151 0.191 A 301 286 12 0 0 12 [[207, 497]] 1.0 6z36 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S77A Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509,BAQ:510 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.391 13.291 BLAminus -123.97, 162.56 76.16, 90.86 -104.32, 25.92 302.2, 176.49 -70.33, -17.0 in-out in 9.193 Saltbr-out 6.166 HRD-in -75.36, -54.06 76.91, 1.59 out-in-out SNCoio in-out ActLoopNT-in 2.928 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.85, 171.29 APE9-dihe-na -63.22, 166.14 APE8-dihe-in -65.07, 121.84 APE8-rot-in 300.34 APE67-dihe-in -56.11, -31.98 -61.83, -38.01 APE12-dist-none 999.0 APE11-dist-out 6.3 APE10-dist-out 8.852 APE9-dist-in 3.638 Q207D None None XRAY 1.31 0.166 0.185 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s77 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7DA Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509,XHD:510 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.386 13.391 BLAminus -121.08, 159.87 78.87, 90.19 -102.41, 28.04 302.41, 178.35 -70.75, -16.32 in-out in 9.224 Saltbr-out 6.135 HRD-in -78.63, -52.52 79.29, -0.45 out-in-out SNCoio in-out ActLoopNT-in 2.957 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -121.09, 171.05 APE9-dihe-na -61.33, 164.08 APE8-dihe-in -64.43, 124.8 APE8-rot-in 301.32 APE67-dihe-in -57.7, -30.13 -64.02, -36.73 APE12-dist-none 999.0 APE11-dist-out 6.226 APE10-dist-out 8.895 APE9-dist-in 3.71 Q207D None None XRAY 1.31 0.165 0.185 A 301 284 14 0 0 12 [[207, 497]] 1.0 5s7d Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7JA Q04771 201 499 509.0 LU8:501,LU8:506,LU8:507,XHG:508 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.354 13.467 BLAminus -120.47, 161.42 75.57, 90.44 -100.52, 24.64 297.99, 178.42 -66.79, -16.07 in-out in 9.118 Saltbr-out 6.109 HRD-in -76.74, -56.59 80.01, 1.36 out-in-out SNCoio in-out ActLoopNT-in 2.897 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -124.11, 169.97 APE9-dihe-na -61.08, 166.56 APE8-dihe-in -64.82, 124.61 APE8-rot-in 302.51 APE67-dihe-in -56.89, -31.73 -63.18, -39.12 APE12-dist-in 10.44 APE11-dist-out 6.043 APE10-dist-out 8.855 APE9-dist-in 3.701 Q207D None None XRAY 1.31 0.159 0.181 A 301 286 13 0 0 11 [[207, 497]] 1.0 5s7j Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7KA Q04771 202 499 509.0 LU8:501,LU8:506,LU8:507,XEJ:508 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.357 13.298 BLAminus -121.51, 161.1 74.44, 89.19 -99.73, 25.08 301.6, 0.3 -69.43, -16.12 in-out in 9.317 Saltbr-out 6.016 HRD-in -77.56, -55.15 80.71, -0.51 out-in-none SNCoin in-none ActLoopNT-in 2.929 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -93.42, -15.71 APE9-dihe-na -77.62, 169.4 APE8-dihe-in -59.03, 123.75 APE8-rot-in 304.14 APE67-dihe-in -58.63, -30.05 -60.7, -39.73 APE12-dist-none 999.0 APE11-dist-in 11.796 APE10-dist-in 6.009 APE9-dist-in 3.542 None None None XRAY 1.31 0.162 0.188 A 301 285 13 0 0 11 [[207, 497]] 1.0 5s7k Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7LA Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508,XHJ:509 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.321 13.334 BLAminus -121.54, 163.42 75.33, 89.93 -101.4, 25.91 299.12, 0.16 -70.86, -16.31 in-out in 9.018 Saltbr-out 5.843 HRD-in -77.38, -52.76 78.01, -1.55 out-in-out SNCoio in-out ActLoopNT-in 2.895 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -125.9, 174.3 APE9-dihe-na -64.5, 161.75 APE8-dihe-in -61.28, 122.78 APE8-rot-in 301.43 APE67-dihe-in -55.46, -32.76 -59.71, -41.51 APE12-dist-in 10.728 APE11-dist-out 6.281 APE10-dist-out 8.784 APE9-dist-in 3.735 Q207D None None XRAY 1.36 0.167 0.188 A 301 286 13 0 0 11 [[207, 497]] 1.0 5s7l Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7MA Q04771 202 499 509.0 LU8:501,LU8:507,HVK:508,HVK:509 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.295 13.369 BLAminus -125.86, 158.69 77.31, 90.22 -102.58, 22.57 301.89, 179.15 -62.4, -27.33 in-out in 9.275 Saltbr-out 6.039 HRD-in -76.09, -53.81 76.66, 2.88 out-in-out SNCoio in-out ActLoopNT-in 2.901 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -128.0, 172.86 APE9-dihe-na -61.78, 157.6 APE8-dihe-in -61.33, 123.11 APE8-rot-in 304.71 APE67-dihe-in -54.75, -34.14 -63.89, -37.36 APE12-dist-in 11.01 APE11-dist-out 6.316 APE10-dist-out 8.773 APE9-dist-in 3.828 Q207D None None XRAY 1.32 0.171 0.195 A 301 285 13 0 0 10 [[207, 497]] 1.0 5s7m Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7NA Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508,2AI:509 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.369 13.327 BLAminus -120.76, 160.23 77.83, 89.81 -101.82, 25.77 300.77, 176.65 -67.07, -19.31 in-out in 9.191 Saltbr-out 6.199 HRD-in -78.31, -53.54 78.72, -0.87 out-in-out SNCoio in-out ActLoopNT-in 2.927 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -111.12, 164.18 APE9-dihe-na -67.39, 173.07 APE8-dihe-in -61.91, 122.38 APE8-rot-in 303.15 APE67-dihe-in -57.78, -31.63 -60.2, -38.53 APE12-dist-none 999.0 APE11-dist-out 7.866 APE10-dist-out 9.173 APE9-dist-in 3.645 Q207D None None XRAY 1.3 0.163 0.186 A 301 286 13 0 0 13 [[207, 497]] 1.0 5s7n Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7PA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508,V1L:509 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.363 13.352 BLAminus -121.35, 161.97 76.5, 90.18 -103.45, 27.08 300.94, 178.65 -69.09, -20.15 in-out in 9.174 Saltbr-out 6.181 HRD-in -76.2, -55.65 77.56, 1.63 out-in-out SNCoio in-out ActLoopNT-in 2.934 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -124.42, 170.99 APE9-dihe-na -65.1, 166.64 APE8-dihe-in -64.52, 122.28 APE8-rot-in 301.0 APE67-dihe-in -57.28, -33.44 -60.97, -37.49 APE12-dist-none 999.0 APE11-dist-out 6.336 APE10-dist-out 8.81 APE9-dist-in 3.648 Q207D None None XRAY 1.31 0.158 0.176 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s7p Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7SA Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509,09V:510 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.374 13.26 BLAminus -125.11, 163.99 74.48, 91.32 -103.07, 26.34 302.08, 178.93 -70.93, -18.68 in-out in 9.134 Saltbr-out 5.937 HRD-in -77.09, -53.7 75.14, 2.55 out-in-out SNCoio in-out ActLoopNT-in 2.917 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.89, 171.8 APE9-dihe-na -59.35, 163.03 APE8-dihe-in -63.02, 122.62 APE8-rot-in 301.85 APE67-dihe-in -55.53, -31.77 -61.45, -39.86 APE12-dist-in 10.584 APE11-dist-out 6.393 APE10-dist-out 8.796 APE9-dist-in 3.663 Q207D None None XRAY 1.3 0.153 0.171 A 301 287 11 0 0 9 [[207, 497]] 1.0 5s7s Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7TB Q04771 205 498 509.0 LU8:501,XGJ:505,XGJ:506,XGJ:507 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 7.348 13.384 BLAminus -130.84, 165.78 74.23, 86.23 -101.88, 22.54 301.68, 171.79 -65.62, -21.79 in-out in 8.842 Saltbr-out 4.37 HRD-in -75.87, -54.78 79.04, -1.82 out-in-out SNCoio in-out ActLoopNT-in 2.937 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -106.86, 165.74 APE9-dihe-na -60.63, 163.96 APE8-dihe-in -61.22, 126.89 APE8-rot-in 299.34 APE67-dihe-in -62.98, -26.85 -63.53, -36.43 APE12-dist-in 10.524 APE11-dist-out 6.968 APE10-dist-out 9.112 APE9-dist-in 3.886 Q207D None None XRAY 1.3 0.155 0.174 B 301 294 0 0 0 0 [[207, 497]] 1.0 5s7t Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7XA Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509,LGA:510 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.365 13.339 BLAminus -120.33, 161.6 75.96, 90.47 -101.36, 24.64 300.81, 178.23 -69.2, -15.97 in-out in 9.153 Saltbr-out 6.131 HRD-in -77.36, -53.88 76.8, 3.92 out-in-out SNCoio in-out ActLoopNT-in 2.943 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.06, 170.39 APE9-dihe-na -62.49, 167.4 APE8-dihe-in -64.84, 124.15 APE8-rot-in 301.78 APE67-dihe-in -56.96, -32.72 -62.72, -36.99 APE12-dist-none 999.0 APE11-dist-out 6.228 APE10-dist-out 8.829 APE9-dist-in 3.662 Q207D None None XRAY 1.3 0.151 0.169 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s7x Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S86A Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508,XK7:509 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.354 13.305 BLAminus -123.41, 163.19 74.35, 90.8 -102.12, 25.57 300.77, 178.94 -68.55, -18.48 in-out in 9.326 Saltbr-out 6.06 HRD-in -80.27, -53.89 78.04, 1.57 out-in-out SNCoio in-out ActLoopNT-in 2.929 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.39, 173.24 APE9-dihe-na -67.68, 166.72 APE8-dihe-in -62.8, 124.74 APE8-rot-in 300.74 APE67-dihe-in -57.85, -29.86 -60.17, -41.27 APE12-dist-none 999.0 APE11-dist-out 6.458 APE10-dist-out 9.142 APE9-dist-in 3.512 Q207D None None XRAY 1.31 0.169 0.19 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s86 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S89A Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508,XKV:509 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.347 13.377 BLAminus -121.17, 161.16 76.55, 91.35 -102.29, 27.94 301.32, 178.72 -70.17, -17.75 in-out in 9.327 Saltbr-out 6.181 HRD-in -77.92, -53.6 79.17, 0.85 out-in-out SNCoio in-out ActLoopNT-in 2.929 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -120.5, 170.79 APE9-dihe-na -62.09, 168.52 APE8-dihe-in -64.51, 125.09 APE8-rot-in 300.94 APE67-dihe-in -58.18, -30.47 -62.43, -38.68 APE12-dist-none 999.0 APE11-dist-out 6.222 APE10-dist-out 9.136 APE9-dist-in 3.611 Q207D None None XRAY 1.3 0.156 0.174 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s89 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S8AA Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509,XKY:510 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.375 13.291 BLAminus -123.48, 162.27 75.26, 91.11 -103.25, 28.11 302.42, 0.24 -70.28, -18.37 in-out in 9.291 Saltbr-out 6.087 HRD-in -77.3, -55.71 79.01, -0.21 out-in-out SNCoio in-out ActLoopNT-in 2.931 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.8, 171.85 APE9-dihe-na -62.19, 164.47 APE8-dihe-in -62.15, 125.78 APE8-rot-in 303.5 APE67-dihe-in -57.64, -30.13 -63.86, -37.62 APE12-dist-none 999.0 APE11-dist-out 6.227 APE10-dist-out 8.893 APE9-dist-in 3.683 Q207D None None XRAY 1.3 0.158 0.179 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s8a Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S8BB Q04771 205 499 509.0 LU8:501,XFV:505,XFV:506,XFV:507 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 6.886 13.268 BLAminus -123.76, 160.92 77.33, 89.17 -99.67, 18.5 303.55, 1.64 -66.62, -18.66 in-out in 8.624 Saltbr-out 4.582 HRD-in -80.97, -53.82 77.81, 1.71 out-in-out SNCoio in-out ActLoopNT-in 2.843 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.23, 169.28 APE9-dihe-na -63.35, 164.6 APE8-dihe-in -57.58, 127.02 APE8-rot-in 306.31 APE67-dihe-in -56.16, -27.82 -54.33, -48.01 APE12-dist-in 10.287 APE11-dist-out 6.129 APE10-dist-out 8.943 APE9-dist-in 3.776 Q207D None None XRAY 1.64 0.2 0.233 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s8b Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S75A Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509,HUH:510,HUH:511 Type1,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.412 13.311 BLAminus -121.86, 161.2 77.57, 90.63 -103.17, 26.39 302.13, 178.97 -70.27, -17.43 in-out in 9.196 Saltbr-out 6.106 HRD-in -77.34, -53.49 77.65, 2.76 out-in-out SNCoio in-out ActLoopNT-in 2.943 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.16, 170.77 APE9-dihe-na -65.21, 166.76 APE8-dihe-in -64.6, 123.77 APE8-rot-in 302.54 APE67-dihe-in -59.09, -30.5 -61.28, -37.14 APE12-dist-none 999.0 APE11-dist-out 6.22 APE10-dist-out 8.913 APE9-dist-in 3.689 Q207D None None XRAY 1.3 0.156 0.173 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s75 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7AA Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508,T5V:509,T5V:510 Type1,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.342 13.314 BLAminus -121.52, 160.72 75.85, 90.49 -101.87, 26.96 302.71, 179.1 -70.78, -16.97 in-out in 9.195 Saltbr-out 6.179 HRD-in -77.37, -53.71 77.98, -0.37 out-in-out SNCoio in-out ActLoopNT-in 2.92 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -125.86, 170.85 APE9-dihe-na -58.96, 161.85 APE8-dihe-in -63.33, 122.4 APE8-rot-in 301.84 APE67-dihe-in -56.7, -33.07 -63.45, -35.84 APE12-dist-none 999.0 APE11-dist-out 6.366 APE10-dist-out 8.852 APE9-dist-in 3.668 Q207D None None XRAY 1.3 0.16 0.18 A 301 285 14 0 0 12 [[207, 497]] 1.0 5s7a Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7BA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508,XH7:509,XH7:510 Type1,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.406 13.352 BLAminus -122.54, 161.25 77.75, 89.14 -102.53, 25.49 298.26, 177.49 -68.5, -17.41 in-out in 9.156 Saltbr-out 5.962 HRD-in -75.98, -54.72 78.12, -0.13 out-in-out SNCoio in-out ActLoopNT-in 2.908 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -121.74, 156.48 APE9-dihe-na -76.58, -177.16 APE8-dihe-in -62.22, 124.84 APE8-rot-in 304.94 APE67-dihe-in -57.93, -31.87 -59.46, -41.19 APE12-dist-out 5.286 APE11-dist-in 8.586 APE10-dist-out 9.311 APE9-dist-in 3.678 Q207D None None XRAY 1.32 0.169 0.195 A 301 285 13 0 0 10 [[207, 497]] 1.0 5s7b Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7HA Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508,HVB:509,HVB:510 Type1,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.4 13.349 BLAminus -122.03, 161.2 75.68, 88.77 -99.68, 25.56 301.4, 178.71 -69.41, -15.19 in-out in 9.284 Saltbr-out 6.112 HRD-in -74.82, -53.78 79.5, -0.11 out-in-out SNCoio in-out ActLoopNT-in 2.955 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -124.66, 158.62 APE9-dihe-na -71.55, -178.8 APE8-dihe-in -67.44, 125.65 APE8-rot-in 300.35 APE67-dihe-in -57.2, -30.23 -61.33, -40.16 APE12-dist-none 999.0 APE11-dist-out 6.417 APE10-dist-out 9.333 APE9-dist-in 3.616 Q207D None None XRAY 1.3 0.158 0.18 A 301 284 15 0 0 12 [[207, 497]] 1.0 5s7h Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7ZA Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509,BYZ:510,BYZ:511 Type1,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.371 13.379 BLAminus -118.29, 164.94 73.01, 90.28 -101.45, 25.18 297.95, 179.49 -66.08, -18.47 in-out in 9.035 Saltbr-out 5.816 HRD-in -75.5, -56.61 78.44, 1.56 out-in-out SNCoio in-out ActLoopNT-in 2.884 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.97, 169.25 APE9-dihe-na -61.57, 164.92 APE8-dihe-in -63.28, 125.7 APE8-rot-in 303.7 APE67-dihe-in -57.35, -34.69 -61.46, -39.19 APE12-dist-in 10.584 APE11-dist-out 6.283 APE10-dist-out 8.904 APE9-dist-in 3.732 Q207D None None XRAY 1.3 0.163 0.184 A 301 287 11 0 0 9 [[207, 497]] 1.0 5s7z Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S81B Q04771 208 499 509.0 LU8:501,XJV:505,XJV:506,XJV:507,XJV:508 Type1,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 7.098 13.469 BLAminus -122.8, 162.49 76.01, 87.95 -102.27, 24.4 302.62, 170.08 -70.81, -17.85 in-out in 8.791 Saltbr-out 4.612 HRD-in -80.16, -52.27 79.27, -5.04 out-in-out SNCoio in-out ActLoopNT-in 2.944 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.12, 164.98 APE9-dihe-na -61.51, 162.25 APE8-dihe-in -57.76, 127.22 APE8-rot-in 301.4 APE67-dihe-in -60.84, -27.37 -62.01, -41.07 APE12-dist-in 10.36 APE11-dist-out 6.197 APE10-dist-out 8.99 APE9-dist-in 3.889 Q207D None None XRAY 1.43 0.17 0.196 B 301 289 3 0 0 0 [[207, 497]] 1.0 5s81 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7CA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508,T5Y:509,T5Y:510,T5Y:511 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.339 13.345 BLAminus -122.66, 161.69 76.15, 92.72 -104.11, 24.78 300.15, 178.43 -66.33, -20.88 in-out in 9.231 Saltbr-out 6.155 HRD-in -76.23, -54.18 77.19, 0.83 out-in-out SNCoio in-out ActLoopNT-in 2.951 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -124.75, 170.87 APE9-dihe-na -60.45, 165.58 APE8-dihe-in -64.98, 123.25 APE8-rot-in 303.45 APE67-dihe-in -56.7, -31.98 -63.36, -36.72 APE12-dist-none 999.0 APE11-dist-out 6.251 APE10-dist-out 8.809 APE9-dist-in 3.72 Q207D None None XRAY 1.31 0.161 0.179 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s7c Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7IA Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508,HV2:509,HV2:510,HV2:511 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.423 13.414 BLAminus -121.19, 161.49 77.75, 90.77 -102.55, 26.67 296.81, 175.99 -70.08, -16.54 in-out in 9.154 Saltbr-out 6.197 HRD-in -79.1, -52.38 76.17, 1.2 out-in-out SNCoio in-out ActLoopNT-in 2.887 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.34, 168.68 APE9-dihe-na -65.41, 166.87 APE8-dihe-in -63.35, 124.96 APE8-rot-in 301.24 APE67-dihe-in -56.97, -30.73 -63.49, -38.5 APE12-dist-none 999.0 APE11-dist-out 6.048 APE10-dist-out 8.899 APE9-dist-in 3.691 Q207D None None XRAY 1.3 0.158 0.176 A 301 284 15 0 0 13 [[207, 497]] 1.0 5s7i Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7TA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508,XGJ:509,XGJ:510,XGJ:511 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.364 13.358 BLAminus -122.53, 161.24 78.81, 92.17 -103.84, 26.27 299.68, 1.07 -70.27, -17.35 in-out in 9.187 Saltbr-out 6.102 HRD-in -73.55, -56.12 78.98, 0.06 out-in-out SNCoio in-out ActLoopNT-in 2.945 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -126.64, 169.46 APE9-dihe-na -62.74, 163.72 APE8-dihe-in -63.21, 123.01 APE8-rot-in 300.97 APE67-dihe-in -58.38, -31.17 -61.88, -38.7 APE12-dist-none 999.0 APE11-dist-out 6.217 APE10-dist-out 8.878 APE9-dist-in 3.708 Q207D None None XRAY 1.3 0.155 0.174 A 301 284 14 0 0 12 [[207, 497]] 1.0 5s7t Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7YB Q04771 207 499 509.0 LU8:501,XJP:505,XJP:506,XJP:507,XJP:508,XJP:509 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 7.015 13.427 BLAminus -126.98, 162.69 75.57, 89.14 -100.94, 21.08 303.3, 173.42 -67.07, -20.24 in-out in 8.841 Saltbr-out 4.734 HRD-in -81.6, -53.06 80.61, -4.28 out-in-out SNCoio in-out ActLoopNT-in 2.929 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.96, 164.75 APE9-dihe-na -61.91, 164.34 APE8-dihe-in -58.26, 128.88 APE8-rot-in 298.27 APE67-dihe-in -57.49, -30.88 -60.34, -41.77 APE12-dist-in 10.326 APE11-dist-out 6.153 APE10-dist-out 9.087 APE9-dist-in 3.766 Q207D None None XRAY 1.37 0.161 0.184 B 301 290 3 0 0 0 [[207, 497]] 1.0 5s7y Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7RB Q04771 205 499 509.0 LU8:501,XGS:505,XGS:506,XGS:507,XGS:508,XGS:509,XGS:510 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 6.951 13.305 BLAminus -123.51, 161.17 75.08, 89.73 -101.63, 18.32 302.56, 179.54 -66.27, -18.2 in-out in 8.728 Saltbr-out 4.754 HRD-in -80.45, -51.89 79.75, -1.22 out-in-out SNCoio in-out ActLoopNT-in 2.924 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.67, 165.96 APE9-dihe-na -61.08, 162.39 APE8-dihe-in -58.43, 128.17 APE8-rot-in 299.47 APE67-dihe-in -59.07, -29.26 -60.13, -43.27 APE12-dist-in 10.312 APE11-dist-out 6.107 APE10-dist-out 9.033 APE9-dist-in 3.879 Q207D None None XRAY 1.46 0.173 0.198 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s7r Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S85A Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508,XK4:509,XK4:510,XK4:511,XK4:512 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.382 13.334 BLAminus -122.41, 161.16 77.18, 90.52 -102.57, 24.0 300.65, 177.17 -69.5, -18.6 in-out in 9.166 Saltbr-out 6.074 HRD-in -76.19, -53.3 76.63, 0.17 out-in-out SNCoio in-out ActLoopNT-in 2.905 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -127.51, 169.88 APE9-dihe-na -65.71, 163.81 APE8-dihe-in -61.83, 125.14 APE8-rot-in 302.55 APE67-dihe-in -58.05, -31.45 -63.04, -37.5 APE12-dist-none 999.0 APE11-dist-out 6.228 APE10-dist-out 8.855 APE9-dist-in 3.736 Q207D None None XRAY 1.33 0.162 0.182 A 301 282 16 0 0 13 [[207, 497]] 1.0 5s85 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S8BA Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508,XFV:509,XFV:510,XFV:511,XFV:512 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.325 13.272 BLAminus -118.75, 157.39 80.5, 89.5 -103.48, 23.68 297.02, 5.33 -69.81, -17.79 in-out in 9.013 Saltbr-out 5.982 HRD-in -76.49, -52.01 73.71, 3.51 out-in-out SNCoio in-out ActLoopNT-in 2.865 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -132.81, 169.84 APE9-dihe-na -47.57, 153.77 APE8-dihe-in -59.87, 123.35 APE8-rot-in 304.85 APE67-dihe-in -51.72, -35.23 -61.3, -40.47 APE12-dist-none 999.0 APE11-dist-out 6.414 APE10-dist-out 8.81 APE9-dist-in 3.699 Q207D None None XRAY 1.64 0.2 0.233 A 301 284 15 0 0 13 [[207, 497]] 1.0 5s8b Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7RA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508,XGS:509,XGS:510,XGS:511,XGS:512,XGS:513 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.379 13.267 BLAminus -118.49, 160.3 77.59, 89.22 -102.83, 29.26 299.84, 3.52 -70.9, -18.65 in-out in 9.113 Saltbr-out 6.246 HRD-in -79.07, -53.38 77.46, -1.57 out-in-out SNCoio in-out ActLoopNT-in 2.923 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -126.05, 166.06 APE9-dihe-na -58.33, 162.52 APE8-dihe-in -61.2, 125.14 APE8-rot-in 304.32 APE67-dihe-in -53.36, -31.96 -64.07, -40.51 APE12-dist-none 999.0 APE11-dist-out 6.085 APE10-dist-out 8.947 APE9-dist-in 3.715 Q207D None None XRAY 1.46 0.173 0.198 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s7r Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7IB Q04771 205 499 509.0 LU8:501,HV2:505,HV2:506,HV2:507,HV2:508,HV2:509,HV2:510,HV2:511,HV2:512,HV2:513 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 7.03 13.347 BLAminus -124.03, 163.17 76.81, 90.06 -103.28, 20.27 301.31, 176.76 -69.97, -14.64 in-out in 8.754 Saltbr-out 4.763 HRD-in -75.19, -55.72 81.55, -2.41 out-in-out SNCoio in-out ActLoopNT-in 2.95 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.42, 164.49 APE9-dihe-na -59.34, 164.13 APE8-dihe-in -60.56, 130.0 APE8-rot-in 297.57 APE67-dihe-in -61.93, -26.2 -62.79, -39.84 APE12-dist-in 10.344 APE11-dist-out 6.121 APE10-dist-out 9.023 APE9-dist-in 3.853 Q207D None None XRAY 1.3 0.158 0.176 B 301 294 1 0 0 0 [[207, 497]] 1.0 5s7i Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S78A Q04771 202 499 509.0 LU8:501,LU8:506,LU8:507,XGV:508,XGV:509,XGV:510 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Type1 Inactive DFGin 8.324 13.355 BLAminus -121.42, 162.3 75.56, 91.97 -103.54, 25.72 302.81, 1.93 -71.55, -16.97 in-out in 9.272 Saltbr-out 6.297 HRD-in -75.89, -55.37 78.61, -0.74 out-in-out SNCoio in-out ActLoopNT-in 2.905 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -123.0, 170.53 APE9-dihe-na -61.1, 164.91 APE8-dihe-in -65.24, 123.82 APE8-rot-in 300.79 APE67-dihe-in -58.43, -30.55 -62.87, -37.3 APE12-dist-in 9.447 APE11-dist-out 6.142 APE10-dist-out 8.902 APE9-dist-in 3.676 Q207D None None XRAY 1.3 0.16 0.177 A 301 285 13 0 0 11 [[207, 497]] 1.0 5s78 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S81A Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509,XJV:510,XJV:511 Type1,Allosteric,Allosteric,Allosteric,Type1 Inactive DFGin 8.317 13.29 BLAminus -119.91, 161.36 74.15, 90.65 -102.16, 24.41 299.52, 0.73 -66.2, -16.75 in-out in 9.161 Saltbr-out 6.217 HRD-in -73.39, -56.79 82.29, -0.98 out-in-out SNCoio in-out ActLoopNT-in 2.905 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -125.7, 171.05 APE9-dihe-na -60.67, 164.13 APE8-dihe-in -64.52, 125.11 APE8-rot-in 304.88 APE67-dihe-in -56.55, -33.14 -61.08, -40.13 APE12-dist-none 999.0 APE11-dist-out 6.189 APE10-dist-out 8.862 APE9-dist-in 3.68 Q207D None None XRAY 1.43 0.17 0.196 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s81 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S76A Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508,02A:509,02A:510 Type1,Allosteric,Allosteric,Allosteric,Type1.5_Back Inactive DFGin 8.397 13.352 BLAminus -125.71, 163.24 76.56, 90.11 -103.29, 26.3 299.59, 179.12 -70.47, -16.36 in-out in 9.169 Saltbr-out 6.136 HRD-in -78.12, -53.94 78.79, 0.3 out-in-out SNCoio in-out ActLoopNT-in 2.91 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -121.64, 170.51 APE9-dihe-na -62.2, 167.24 APE8-dihe-in -63.35, 123.08 APE8-rot-in 302.24 APE67-dihe-in -58.65, -29.05 -63.37, -35.67 APE12-dist-none 999.0 APE11-dist-out 6.224 APE10-dist-out 8.912 APE9-dist-in 3.673 Q207D None None XRAY 1.31 0.156 0.173 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s76 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7LB Q04771 205 499 509.0 LU8:501,XHJ:505,XHJ:506,XHJ:507,XHJ:508 Type1,Allosteric,Allosteric,Allosteric,Type3 Inactive DFGin 7.111 13.39 BLAminus -125.42, 162.47 77.36, 89.52 -102.53, 17.7 300.76, 174.49 -63.63, -17.96 in-out in 8.786 Saltbr-out 4.457 HRD-in -76.1, -52.38 79.68, -4.98 out-in-out SNCoio in-out ActLoopNT-in 2.936 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -116.61, 167.49 APE9-dihe-na -61.83, 166.04 APE8-dihe-in -62.17, 127.63 APE8-rot-in 299.54 APE67-dihe-in -59.75, -27.49 -60.2, -41.98 APE12-dist-in 10.437 APE11-dist-out 6.397 APE10-dist-out 9.019 APE9-dist-in 3.894 Q207D None None XRAY 1.36 0.167 0.188 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s7l Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S84A Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508,XK1:509 Type1,Allosteric,Allosteric,Type1 Inactive DFGin 8.336 13.439 BLAminus -118.42, 161.89 75.73, 89.87 -101.05, 26.48 297.86, 0.33 -68.45, -15.46 in-out in 9.125 Saltbr-out 6.08 HRD-in -77.01, -56.17 80.15, -0.22 out-in-out SNCoio in-out ActLoopNT-in 2.895 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -124.67, 170.99 APE9-dihe-na -62.03, 164.12 APE8-dihe-in -62.23, 123.92 APE8-rot-in 305.79 APE67-dihe-in -60.01, -30.93 -61.35, -38.64 APE12-dist-none 999.0 APE11-dist-out 6.133 APE10-dist-out 8.839 APE9-dist-in 3.68 Q207D None None XRAY 1.35 0.166 0.191 A 301 284 15 0 0 13 [[207, 497]] 1.0 5s84 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S83A Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509,XJY:510 Type1,Allosteric,Allosteric,Type3 Inactive DFGin 8.442 13.223 BLAminus -121.45, 166.08 75.52, 89.79 -103.21, 23.07 300.9, 0.69 -66.79, -19.18 in-out in 8.966 Saltbr-out 5.632 HRD-in -77.39, -55.22 76.55, 2.24 out-in-out SNCoio in-out ActLoopNT-in 2.91 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.02, 170.52 APE9-dihe-na -63.69, 168.74 APE8-dihe-in -66.61, 121.49 APE8-rot-in 303.57 APE67-dihe-in -53.26, -35.15 -59.02, -40.84 APE12-dist-none 999.0 APE11-dist-out 6.342 APE10-dist-out 8.87 APE9-dist-in 3.756 Q207D None None XRAY 1.33 0.161 0.185 A 301 283 15 0 0 13 [[207, 497]] 1.0 5s83 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S7OB Q04771 205 499 509.0 LU8:501,XJJ:505 Type1,Type1 Inactive DFGin 6.984 13.382 BLAminus -123.75, 162.83 73.51, 87.08 -99.67, 20.63 303.58, 175.53 -70.31, -13.4 in-out in 8.854 Saltbr-out 4.755 HRD-in -78.42, -53.12 79.9, -3.76 out-in-out SNCoio in-out ActLoopNT-in 2.942 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.12, 167.38 APE9-dihe-na -65.37, 165.19 APE8-dihe-in -58.94, 129.63 APE8-rot-in 299.85 APE67-dihe-in -59.51, -26.9 -60.64, -42.85 APE12-dist-in 10.331 APE11-dist-out 6.192 APE10-dist-out 9.027 APE9-dist-in 3.856 Q207D None None XRAY 1.43 0.165 0.189 B 301 295 0 0 0 0 [[207, 497]] 1.0 5s7o Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S85B Q04771 207 499 509.0 LU8:501,XK4:505,XK4:506,XK4:507 Type1,Type1,Allosteric,Allosteric Inactive DFGin 6.993 13.374 BLAminus -127.18, 161.1 77.88, 88.72 -101.83, 19.04 301.72, 175.14 -66.37, -15.29 in-out in 8.713 Saltbr-out 4.605 HRD-in -77.44, -53.87 79.87, -4.46 out-in-out SNCoio in-out ActLoopNT-in 2.933 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.46, 164.3 APE9-dihe-na -59.94, 165.51 APE8-dihe-in -60.21, 126.73 APE8-rot-in 299.02 APE67-dihe-in -60.44, -25.63 -60.52, -40.57 APE12-dist-in 10.351 APE11-dist-out 6.21 APE10-dist-out 9.033 APE9-dist-in 3.811 Q207D None None XRAY 1.33 0.162 0.182 B 301 290 3 0 0 0 [[207, 497]] 1.0 5s85 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S76B Q04771 205 499 509.0 LU8:501,02A:505 Type1,Type1.5_Back Inactive DFGin 7.045 13.388 BLAminus -126.37, 161.8 77.8, 87.16 -99.2, 20.64 303.2, 173.97 -68.3, -17.34 in-out in 8.888 Saltbr-out 4.735 HRD-in -77.8, -54.12 78.31, -2.4 out-in-out SNCoio in-out ActLoopNT-in 2.942 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.39, 162.33 APE9-dihe-na -57.18, 164.84 APE8-dihe-in -61.8, 127.01 APE8-rot-in 299.22 APE67-dihe-in -57.98, -30.25 -60.93, -39.7 APE12-dist-in 10.389 APE11-dist-out 6.192 APE10-dist-out 9.078 APE9-dist-in 3.758 Q207D None None XRAY 1.31 0.156 0.173 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s76 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 5S9KB Q04771 205 499 509.0 LU8:501,YV4:505 Type1,Type3 Inactive DFGin 6.899 13.311 BLAminus -124.0, 163.62 77.74, 89.17 -103.64, 24.26 305.37, 1.01 -72.01, -17.07 in-out in 8.812 Saltbr-out 4.66 HRD-in -80.23, -51.12 77.76, -2.54 out-in-out SNCoio in-out ActLoopNT-in 2.922 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.95, 165.67 APE9-dihe-na -60.95, 168.37 APE8-dihe-in -63.37, 128.29 APE8-rot-in 299.42 APE67-dihe-in -54.29, -31.02 -58.7, -45.73 APE12-dist-in 10.331 APE11-dist-out 6.186 APE10-dist-out 8.992 APE9-dist-in 3.687 Q207D None None XRAY 1.35 0.176 0.2 B 301 292 3 0 0 0 [[207, 497]] 1.0 5s9k Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 6T6DA Q04771 204 499 509.0 MM8:501 Type1 Inactive DFGin 8.309 13.284 None -109.51, -81.12 -73.5, 111.71 -110.98, 17.65 271.3, 88.6 -66.37, -17.62 in-in in 8.137 Saltbr-in 3.496 HRD-in -71.72, -59.58 84.73, 1.24 in-in-in SNCiii in-in ActLoopNT-in 2.883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.15, 12.06 APE9-dihe-na -92.9, 178.87 APE8-dihe-in -69.31, 121.79 APE8-rot-in 306.54 APE67-dihe-in -58.18, -27.15 -60.78, -34.02 APE12-dist-in 12.163 APE11-dist-in 11.761 APE10-dist-in 6.614 APE9-dist-in 3.775 Q207D None None XRAY 2.56 0.224 0.272 A 301 292 4 0 0 4 [[207, 497]] 1.0 6t6d Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
ACVR1_HUMAN 8R7GC Q04771 206 498 509.0 YEE:501 Type1 None DFGin 7.86 12.623 BLAminus -132.3, 171.44 65.89, 83.48 -96.38, 20.1 305.34, 173.35 -63.32, -22.24 in-in in 8.155 Saltbr-in 3.027 HRD-in -79.84, -56.85 80.44, 0.82 in-in-none SNCiin in-none ActLoopNT-in 2.792 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -50.52 APE9-dihe-na -69.1, 173.0 APE8-dihe-in -60.22, 124.79 APE8-rot-in 310.22 APE67-dihe-in -65.34, -27.73 -64.05, -29.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.082 APE9-dist-in 3.578 Q207D None None XRAY 2.09 0.228 0.253 C 301 280 13 0 0 12 [[207, 497]] 1.0 8r7g Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1

TKL_ACVR1 (Activin receptor type-1)

Total number of chains: 0
Active chains: 0
Family: TKL
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name