Ligand: BYZ

Total number of chains: 5
Active chains: 2
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 80.0% 5S7ZB
None None 1 20.0% 6Q3CA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
CMGC CDK2 CDK2_HUMAN 9ETPC 2.48 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BYZ, BYZ, BYZ Type1, Allosteric, Allosteric 1 - 296 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9ETPA 2.48 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BYZ, BYZ, BYZ, BYZ, BYZ, BYZ Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 1 - 297 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 6Q3CA 1.29 Inactive None‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo BYZ, BYZ Type1, Type1 2 - 298 0 None None Cyclin-dependent kinase 2
TKL ACVR1 ACVR1_HUMAN 5S7ZB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, BYZ Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7ZA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8, BYZ, BYZ Type1, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1

Ligand: BYZ

Total number of chains: 5
Active chains: 2
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 80.0% 5S7ZB
None None 1 20.0% 6Q3CA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC CDK2 CDK2_HUMAN 9ETPC 2.48 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BYZ, BYZ, BYZ Type1, Allosteric, Allosteric 1 - 296 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 9ETPA 2.48 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BYZ, BYZ, BYZ, BYZ, BYZ, BYZ Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 1 - 297 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 6Q3CA 1.29 Inactive None‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo BYZ, BYZ Type1, Type1 2 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7ZB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, BYZ Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7ZA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8, BYZ, BYZ Type1, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens

Ligand: BYZ

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism