IRAK4 (Interleukin-1 receptor-associated kinase 4)

Group: TKL
Uniprot: IRAK4_HUMAN
Domain boundary: 175 - 456


Total number of chains: 209
Spatial Dihedral Chains Representative
DFGin BLAminus 197 AF-Q9NWZ3-K1A
DFGin BLBminus 2 2NRYA
DFGin BLBtrans 1 6EGFB
DFGin None 2 4U97B
DFGout None 4 6EG9A
None None 3 2O8YA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
7C2WA 3.2 Inactive DFGin BLAminus in-out in-in YTH FJ9 Allosteric Type1 164 - 458 None X346 0
7C2WB 3.2 Inactive DFGin BLAminus in-out in-in YTH FJ9 Allosteric Type1 163 - 458 None X346 0
7C2WC 3.2 Inactive DFGin BLAminus in-out in-in YTH FJ9 Allosteric Type1 164 - 458 None X346 0
7C2WD 3.2 Inactive DFGin BLAminus in-out in-in YTH FJ9 Allosteric Type1 164 - 458 None X346 0
AF-Q9NWZ3-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 167 - 460 None None 0
2OIBA 2.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 162 - 458 None X342,X345,X346 4
2OIBB 2.0 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 164 - 459 None X342,X345,X346 5
2OIBC 2.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 161 - 458 None X342,X345,X346 4
2OIBD 2.0 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 162 - 459 None X342,X345,X346 0
6F3DA 2.38 Inactive DFGin BLAminus in-out in-in CJT Type1 164 - 458 None X345,X346 7
6F3DB 2.38 Inactive DFGin BLAminus in-out in-in CJT Type1 164 - 458 None X345,X346 7
6F3EA 2.67 None DFGin BLAminus in-out none-in CJQ Type1 164 - 458 None X342,X345 8
6F3EB 2.67 Inactive DFGin BLAminus in-out in-in CJQ Type1 164 - 458 None X342,X345 5
6F3GA 2.37 Active DFGin BLAminus in-in in-in CJN Type1 164 - 458 None X342,X345,X346 6
6F3GB 2.37 Active DFGin BLAminus in-in in-in CJN Type1 164 - 458 None X345,X346 6
6N8GA 2.0 Active DFGin BLAminus in-in in-in KFD Type1 164 - 459 None X342,X345,X346 4
6N8GB 2.0 Inactive DFGin BLAminus in-out in-in KFD Type1 164 - 459 None X342,X345,X346 5
6N8GC 2.0 Active DFGin BLAminus in-in in-in KFD Type1 164 - 459 None X342,X345,X346 4
6N8GD 2.0 Active DFGin BLAminus in-in in-in KFD Type1 164 - 459 None X342,X345,X346 5
8BR5AAA 2.7 Inactive DFGin BLAminus in-out in-in R73 Type1 163 - 459 None X342,X345,X346 4
8BR5BBB 2.7 Inactive DFGin BLAminus in-out in-in R73 Type1 162 - 459 None X342,X345,X346 5
8BR5CCC 2.7 Inactive DFGin BLAminus in-out in-in R73 Type1 163 - 459 None X342,X345,X346 6
8BR5DDD 2.7 Inactive DFGin BLAminus in-out in-in R73 Type1 164 - 459 None X342,X345,X346 4
7C2VA 2.44 Active DFGin BLAminus in-in in-in FJ0 Type1 163 - 459 None X342,X345,X346 4
7C2VB 2.44 Active DFGin BLAminus in-in in-in FJ0 Type1 162 - 459 None X342,X345,X346 5
7C2VC 2.44 Active DFGin BLAminus in-in in-in FJ0 Type1 164 - 460 None X342,X345,X346 5
7C2VD 2.44 Active DFGin BLAminus in-in in-in FJ0 Type1 164 - 459 None X342,X345,X346 4
2OICA 2.4 Active DFGin BLAminus in-in in-in STU Type1 163 - 458 None X342,X345,X346 6
2OICB 2.4 Active DFGin BLAminus in-in in-in STU Type1 164 - 459 None X342,X345,X346 6
2OICC 2.4 None DFGin BLAminus in-in none-in STU Type1 161 - 458 None X342,X345,X346 10
2OICD 2.4 Active DFGin BLAminus in-in in-in STU Type1 161 - 459 None X342,X345,X346 2
2OIDA 2.3 Inactive DFGin BLAminus out-out in-in ANP Type1 164 - 458 None X342,X345,X346 4
2OIDB 2.3 Inactive DFGin BLAminus in-out in-in ANP Type1 164 - 459 None X342,X345,X346 6
2OIDC 2.3 Inactive DFGin BLAminus in-out in-in ANP Type1 166 - 458 None X342,X345,X346 6
2OIDD 2.3 Active DFGin BLAminus in-in in-in ANP Type1 164 - 459 None X342,X345,X346 3
4XS2A 2.73 Inactive DFGin BLAminus in-out in-in 42P Type1 163 - 459 None X342,X345,X346 4
4XS2B 2.73 Active DFGin BLAminus in-in in-in 42P Type1 161 - 459 None X342,X345,X346 7
4XS2C 2.73 Inactive DFGin BLAminus in-out in-in 42P Type1 164 - 460 None X342,X345,X346 4
4XS2D 2.73 Inactive DFGin BLAminus in-out in-in 42P Type1 164 - 459 None X342,X345,X346 5
4YO6A 2.32 Inactive DFGin BLAminus in-out in-in 4GD Type1 163 - 459 None X342,X345,X346 3
4YO6B 2.32 Active DFGin BLAminus in-in in-in 4GD Type1 161 - 459 None X342,X345,X346 6
4YO6C 2.32 Inactive DFGin BLAminus in-out in-in 4GD Type1 164 - 460 None X342,X345,X346 5
4YP8A 2.641 Active DFGin BLAminus in-in in-in 4GF Type1 164 - 459 None X342,X345,X346 4
4YP8B 2.641 Inactive DFGin BLAminus in-out in-in 4GF Type1 161 - 459 None X342,X345,X346 6
4YP8C 2.641 Inactive DFGin BLAminus in-out in-in 4GF Type1 164 - 460 None X342,X345,X346 4
4YP8D 2.641 Inactive DFGin BLAminus in-out in-in 4GF Type1 164 - 459 None X342,X345,X346 4
4ZTLA 2.39 Active DFGin BLAminus in-in in-in 4S1 Type1 165 - 459 None X342,X345,X346 7
4ZTLB 2.39 Active DFGin BLAminus in-in in-in 4S1 Type1 165 - 459 None X342,X345,X346 6
4ZTLC 2.39 Active DFGin BLAminus in-in in-in 4S1 Type1 164 - 460 None X342,X345,X346 4
4ZTLD 2.39 Inactive DFGin BLAminus in-out in-in 4S1 Type1 164 - 460 None X342,X345,X346 4
4ZTMA 2.66 Active DFGin BLAminus in-in in-in 4S2 Type1 162 - 459 None X342,X345,X346 3
4ZTMB 2.66 Active DFGin BLAminus in-in in-in 4S2 Type1 161 - 459 None X342,X345,X346 6
4ZTMC 2.66 Inactive DFGin BLAminus in-out in-in 4S2 Type1 164 - 460 None X342,X345,X346 4
4ZTMD 2.66 Active DFGin BLAminus in-in in-in 4S2 Type1 164 - 459 None X342,X345,X346 5
4ZTNA 2.23 Inactive DFGin BLAminus in-out in-in 4S3 Type1 163 - 459 None X342,X345,X346 4
4ZTNB 2.23 Active DFGin BLAminus in-in in-in 4S3 Type1 161 - 459 None X342,X345,X346 4
4ZTNC 2.23 Inactive DFGin BLAminus in-out in-in 4S3 Type1 164 - 460 None X342,X345,X346 5
4ZTND 2.23 Inactive DFGin BLAminus in-out in-in 4S3 Type1 164 - 459 None X342,X345,X346 4
5K72A 2.22 Active DFGin BLAminus in-in in-in 6QY Type1 164 - 458 None X345,X346 7
5K72B 2.22 Active DFGin BLAminus in-in in-in 6QY Type1 165 - 458 None X345,X346 14
5K72C 2.22 Active DFGin BLAminus in-in in-in 6QY Type1 164 - 458 None X345,X346 7
5K72D 2.22 Active DFGin BLAminus in-in in-in 6QY Type1 164 - 458 None X345,X346 7
5K75A 2.03 Active DFGin BLAminus in-in in-in 6QX Type1 164 - 458 None X345,X346 8
5K75B 2.03 Inactive DFGin BLAminus in-out in-in 6QX Type1 163 - 458 None X345,X346 6
5K75C 2.03 Inactive DFGin BLAminus in-out in-in 6QX Type1 164 - 458 None X345,X346 6
5K75D 2.03 Inactive DFGin BLAminus in-out in-in 6QX Type1 164 - 458 None X345,X346 5
5K76A 2.74 Inactive DFGin BLAminus in-out in-in 6R1 Type1 165 - 458 None X345,X346 6
5K76B 2.74 Active DFGin BLAminus in-in in-in 6R1 Type1 164 - 458 None X345,X346 7
5K7GA 2.23 Active DFGin BLAminus in-in in-in 6R0 Type1 164 - 458 None X345,X346 7
5K7GB 2.23 Active DFGin BLAminus in-in in-in 6R0 Type1 165 - 458 None X345,X346 14
5K7GC 2.23 Active DFGin BLAminus in-in in-in 6R0 Type1 164 - 458 None X345,X346 7
5K7GD 2.23 Active DFGin BLAminus in-in in-in 6R0 Type1 164 - 458 None X345,X346 7
5K7IA 2.31 Active DFGin BLAminus in-in in-in 6QZ Type1 164 - 458 None X345,X346 7
5K7IB 2.31 Active DFGin BLAminus in-in in-in 6QZ Type1 164 - 458 None X345,X346 7
5KX7B 2.8 Active DFGin BLAminus in-in in-in 6YD Type1 163 - 459 None X342,X345,X346 4
5KX8A 2.671 Active DFGin BLAminus in-in in-in 6YE Type1 163 - 459 None X342,X345,X346 4
5KX8B 2.671 Active DFGin BLAminus in-in in-in 6YE Type1 161 - 459 None X342,X345,X346 6
5KX8C 2.671 Inactive DFGin BLAminus in-out in-in 6YE Type1 164 - 460 None X342,X345,X346 4
5KX8D 2.671 Active DFGin BLAminus in-in in-in 6YE Type1 164 - 459 None X342,X345,X346 5
5T1SA 2.3 Inactive DFGin BLAminus in-out in-in 76Q Type1 163 - 459 None X342,X345,X346 3
5T1SC 2.3 Inactive DFGin BLAminus in-out in-in 76Q Type1 164 - 460 None X342,X345,X346 5
5T1SD 2.3 Active DFGin BLAminus in-in in-in 76Q Type1 164 - 459 None X342,X345,X346 5
5T1TA 2.34 Inactive DFGin BLAminus in-out in-in 76P Type1 163 - 459 None X342,X345,X346 6
5T1TB 2.34 Inactive DFGin BLAminus in-out in-in 76P Type1 161 - 459 None X342,X345,X346 5
5T1TC 2.34 Inactive DFGin BLAminus in-out in-in 76P Type1 164 - 460 None X342,X345,X346 4
5T1TD 2.34 Inactive DFGin BLAminus in-out in-in 76P Type1 164 - 459 None X342,X345,X346 5
4Y73A 2.14 Inactive DFGin BLAminus in-out in-in XPY Type1 163 - 459 None X342,X345,X346 5
4Y73B 2.14 Inactive DFGin BLAminus in-out in-in XPY Type1 161 - 459 None X342,X345,X346 7
4Y73C 2.14 Inactive DFGin BLAminus in-out in-in XPY Type1 164 - 460 None X342,X345,X346 4
4Y73D 2.14 Active DFGin BLAminus in-in in-in XPY Type1 164 - 459 None X342,X345,X346 5
6MOMA 2.1 Active DFGin BLAminus in-in in-in JX4 Type1 164 - 460 None X342,X345,X346 3
6MOMB 2.1 Inactive DFGin BLAminus in-out in-in JX4 Type1 164 - 459 None X342,X345,X346 4
6MOMC 2.1 Active DFGin BLAminus in-in in-in JX4 Type1 163 - 460 None X342,X345,X346 3
6MOMD 2.1 Inactive DFGin BLAminus in-out in-in JX4 Type1 164 - 459 None X342,X345,X346 0
6O8UA 1.8 Inactive DFGin BLAminus in-out in-in LS7 Type1 164 - 458 None X345,X346 6
6O8UB 1.8 Inactive DFGin BLAminus in-out in-in LS7 Type1 160 - 458 None X345,X346 7
6O8UC 1.8 Inactive DFGin BLAminus in-out in-in LS7 Type1 163 - 458 None X345,X346 4
6O8UD 1.8 Inactive DFGin BLAminus in-out in-in LS7 Type1 162 - 458 None X345,X346 6
5W84A 2.9 Active DFGin BLAminus in-in in-in 9YY Type1 165 - 459 None X342,X345,X346 5
5W84B 2.9 None DFGin BLAminus in-none in-in 9YY Type1 168 - 459 None X342,X345,X346 5
5W85A 2.25 Inactive DFGin BLAminus in-out in-in 9YS Type1 164 - 458 None X342,X345,X346 5
5W85B 2.25 Inactive DFGin BLAminus in-out in-in 9YS Type1 164 - 459 None X342,X345,X346 4
6LXYA 2.19 Inactive DFGin BLAminus in-out in-in EXF Type1 163 - 458 None X345,X346 2
6LXYB 2.19 None DFGin BLAminus in-none in-in EXF Type1 163 - 459 None X345,X346 0
6LXYD 2.19 Inactive DFGin BLAminus in-out in-in EXF Type1 162 - 459 None X345,X346 5
6LXYE 2.19 Inactive DFGin BLAminus in-out in-in EXF Type1 164 - 458 None X345,X346 7
6VQLA 2.069 Inactive DFGin BLAminus in-out in-in R7S Type1 162 - 458 None X342,X345,X346 6
6VQLB 2.069 Inactive DFGin BLAminus in-out in-in R7S Type1 163 - 458 None X342,X345,X346 6
6VQLC 2.069 Inactive DFGin BLAminus in-out in-in R7S Type1 163 - 458 None X342,X345,X346 4
6VQLD 2.069 Inactive DFGin BLAminus in-out in-in R7S Type1 164 - 458 None X342,X345,X346 3
2NRUA 2.0 Inactive DFGin BLAminus in-out in-in T12 Type1 164 - 458 None X345,X346 0
2NRUB 2.0 Inactive DFGin BLAminus in-out in-in T12 Type1 163 - 458 None X345,X346 0
2NRUC 2.0 Inactive DFGin BLAminus in-out in-in T12 Type1 164 - 458 None X345,X346 0
2NRUD 2.0 Inactive DFGin BLAminus in-out in-in T12 Type1 164 - 458 None X345,X346 0
2NRYC 2.15 Active DFGin BLAminus in-in in-in STU Type1 164 - 458 None X345 4
2NRYD 2.15 Active DFGin BLAminus in-in in-in STU Type1 164 - 460 None X345 5
4RMZA 2.2 Inactive DFGin BLAminus in-out in-in T20 Type1 165 - 458 None X342,X345,X346 3
4RMZB 2.2 Inactive DFGin BLAminus in-out in-in T20 Type1 165 - 458 None X342,X345,X346 6
6THWA 2.44 Inactive DFGin BLAminus in-out in-in NBK Type1 164 - 458 None None 12
6THWB 2.44 Inactive DFGin BLAminus in-out in-in NBK Type1 164 - 458 None None 11
6THXA 1.99 Active DFGin BLAminus in-in in-in N9Z Type1 164 - 458 None X345,X346 6
6THXB 1.99 Inactive DFGin BLAminus in-out in-in N9Z Type1 164 - 458 None X345,X346 5
6THZA 2.38 Active DFGin BLAminus in-in in-in NB5 Type1 165 - 458 None X345,X346 6
6THZB 2.38 Inactive DFGin BLAminus in-out in-in NB5 Type1 164 - 458 None X345,X346 5
6TI8A 2.32 Active DFGin BLAminus in-in in-in NBW Type1 165 - 459 None X345,X346 6
6TI8B 2.32 Active DFGin BLAminus in-in in-in NBW Type1 165 - 459 None X345,X346 7
6TI8C 2.32 Active DFGin BLAminus in-in in-in NBW Type1 164 - 459 None X345,X346 7
6TI8D 2.32 Active DFGin BLAminus in-in in-in NBW Type1 164 - 458 None X345,X346 7
7QG2A 3.031 Inactive DFGin BLAminus in-out in-in B6I Type1 164 - 458 None X345,X346 6
7QG2B 3.031 Inactive DFGin BLAminus in-out in-in B6I Type1 165 - 458 None X345,X346 8
7QG2C 3.031 Inactive DFGin BLAminus in-out in-in B6I Type1 164 - 458 None X345,X346 7
7QG2D 3.031 Inactive DFGin BLAminus in-out in-in B6I Type1 164 - 458 None X345,X346 7
7QG3A 2.11 Active DFGin BLAminus in-in in-in B4U Type1 164 - 458 None X342,X345,X346 6
7QG3B 2.11 Inactive DFGin BLAminus in-out in-in B4U Type1 164 - 458 None X342,X345,X346 6
7QG5A 2.3 Inactive DFGin BLAminus in-out in-in B7R Type1 165 - 458 None X345,X346 6
7QG5B 2.3 Inactive DFGin BLAminus in-out in-in B7R Type1 164 - 458 None X345,X346 6
6O94A 1.98 Inactive DFGin BLAminus in-out in-in LRS Type1 163 - 458 None X342,X345,X346 4
6O94B 1.98 Inactive DFGin BLAminus in-out in-in LRS Type1 162 - 458 None X342,X345,X346 4
6O94C 1.98 Inactive DFGin BLAminus in-out in-in LRS Type1 163 - 458 None X342,X345,X346 4
6O94D 1.98 Inactive DFGin BLAminus in-out in-in LRS Type1 163 - 458 None X342,X345,X346 5
6O95A 1.77 Inactive DFGin BLAminus in-out in-in LSV Type1 162 - 459 None X342,X345,X346 5
6O95B 1.77 Inactive DFGin BLAminus in-out in-in LSV Type1 163 - 458 None X342,X345,X346 5
6O95C 1.77 Inactive DFGin BLAminus in-out in-in LSV Type1 165 - 458 None X342,X345,X346 5
6O95D 1.77 Inactive DFGin BLAminus in-out in-in LSV Type1 161 - 458 None X342,X345,X346 6
6O9DA 2.51 Inactive DFGin BLAminus in-out in-in LTY Type1 162 - 458 None X342,X345,X346 4
6O9DB 2.51 Inactive DFGin BLAminus in-out in-in LTY Type1 163 - 458 None X342,X345,X346 5
6O9DC 2.51 Active DFGin BLAminus in-in in-in LTY Type1 163 - 458 None X342,X345,X346 5
6O9DD 2.51 Inactive DFGin BLAminus in-out in-in LTY Type1 164 - 458 None X342,X345,X346 3
6UYAA 1.74 Inactive DFGin BLAminus in-out in-in QL7 Type1 163 - 458 None X342,X345,X346 5
6UYAB 1.74 Inactive DFGin BLAminus in-out in-in QL7 Type1 165 - 458 None X342,X345,X346 4
6UYAC 1.74 Active DFGin BLAminus in-in in-in QL7 Type1 162 - 458 None X342,X345,X346 6
6UYAD 1.74 Inactive DFGin BLAminus in-out in-in QL7 Type1 162 - 458 None X342,X345,X346 6
6F3IA 2.14 Inactive DFGin BLAminus in-out in-in CKN Type1 165 - 458 None X345,X346 7
6F3IB 2.14 Inactive DFGin BLAminus in-out in-in CKN Type1 164 - 458 None X345,X346 7
6RFIA 2.31 Inactive DFGin BLAminus in-out in-in K1H Type1 165 - 458 None X345,X346 5
6RFIB 2.31 Inactive DFGin BLAminus in-out in-in K1H Type1 164 - 458 None X345,X346 8
6RFJA 2.61 Inactive DFGin BLAminus in-out in-in K1E Type1 165 - 458 None X345,X346 7
6RFJB 2.61 Inactive DFGin BLAminus in-out in-in K1E Type1 164 - 458 None X345,X346 8
7QG1A 2.07 Inactive DFGin BLAminus in-out in-in B8I Type1 165 - 458 None X345,X346 7
7QG1B 2.07 Inactive DFGin BLAminus in-out in-in B8I Type1 164 - 458 None X345,X346 7
5UIQA 2.64 Inactive DFGin BLAminus in-out in-in 8BV Type1 164 - 459 None X342,X345,X346 4
5UIQB 2.64 Inactive DFGin BLAminus in-out in-in 8BV Type1 164 - 458 None X342,X345,X346 5
5UIQC 2.64 Inactive DFGin BLAminus in-out in-in 8BV Type1 164 - 458 None X342,X345,X346 4
5UIQD 2.64 Inactive DFGin BLAminus in-out in-in 8BV Type1 164 - 458 None X342,X345,X346 6
5UIRA 2.64 Inactive DFGin BLAminus in-out in-in 8BY Type1 165 - 458 None X342,X345,X346 8
5UIRB 2.64 Inactive DFGin BLAminus in-out in-in 8BY Type1 164 - 458 None X342,X345,X346 5
5UISA 2.5 Inactive DFGin BLAminus in-out in-in 8C1 Type1 165 - 458 None X342,X345 8
5UISB 2.5 Inactive DFGin BLAminus in-out in-in 8C1 Type1 165 - 458 None X342,X345 7
5UISC 2.5 Inactive DFGin BLAminus in-out in-in 8C1 Type1 162 - 458 None X342,X345 8
5UISD 2.5 Inactive DFGin BLAminus in-out in-in 8C1 Type1 165 - 458 None X342,X345 8
5UITA 1.84 Inactive DFGin BLAminus in-out in-in 8CD Type1 162 - 458 None X345,X346 5
5UITB 1.84 Inactive DFGin BLAminus in-out in-in 8CD Type1 164 - 458 None X345,X346 5
5UIUA 2.02 Inactive DFGin BLAminus in-out in-in 8CG Type1 165 - 458 None X342,X345,X346 5
5UIUB 2.02 Inactive DFGin BLAminus in-out in-in 8CG Type1 164 - 458 None X342,X345,X346 5
8ATBAAA 2.35 Inactive DFGin BLAminus in-out in-in O0H Type1 165 - 459 K400A,E401A,E402A X345,X346 8
8ATBBBB 2.35 Inactive DFGin BLAminus in-out in-in O0H Type1 165 - 459 K400A,E401A,E402A X345,X346 6
8ATLAAA 2.464 Active DFGin BLAminus in-in in-in O6X Type1 165 - 459 K400A,E401A,E402A X345,X346 7
8ATLBBB 2.464 Active DFGin BLAminus in-in in-in O6X Type1 165 - 459 K400A,E401A,E402A X345,X346 7
8ATNAAA 2.171 Inactive DFGin BLAminus in-out in-in O06 Type1 165 - 459 K400A,E401A,E402A X345,X346 5
8ATNBBB 2.171 Inactive DFGin BLAminus in-out in-in O06 Type1 165 - 459 K400A,E401A,E402A X345,X346 3
8BR6AAA 2.167 Inactive DFGin BLAminus in-out in-in R6I Type1 165 - 459 K400A,E401A,E402A X345,X346 7
8BR6BBB 2.167 Inactive DFGin BLAminus in-out in-in R6I Type1 165 - 459 K400A,E401A,E402A X345,X346 6
8BR7AAA 2.119 Inactive DFGin BLAminus in-out in-in R6R Type1 165 - 458 K400A,E401A,E402A X345,X346 6
8BR7BBB 2.119 Inactive DFGin BLAminus in-out in-in R6R Type1 165 - 458 K400A,E401A,E402A X345,X346 5
8DKSA 2.45 Inactive DFGin BLAminus in-out in-in SO9 Type1 165 - 459 None X346 7
8DKSB 2.45 Inactive DFGin BLAminus in-out in-in SO9 Type1 164 - 459 None X346 6
8WTFA 2.0 Inactive DFGin BLAminus in-out in-in 8CG Type1 165 - 458 None None 0
6EGDA 2.1 None DFGin BLAminus in-in in-none J87 Type1 165 - 458 None None 16
6EGDD 2.1 None DFGin BLAminus in-out in-none J87 Type1 164 - 458 None None 16
6EGEA 1.401 Active DFGin BLAminus in-in in-in DL1 Type1 165 - 459 None None 11
6EGED 1.401 None DFGin BLAminus in-in in-none DL1 Type1 164 - 457 None None 5
4U97A 2.65 None DFGin BLAminus in-in none-in STU Type1 166 - 458 D311N None 8
4U9AA 2.8 None DFGin BLAminus in-in none-in STU Type1 166 - 458 D311N None 8
4YO6D 2.32 Inactive DFGin BLAminus in-out in-in 4GD 4GD Type1 Allosteric 164 - 459 None X342,X345,X346 4
6TIAA 2.52 Inactive DFGin BLAminus in-out in-in ND2 ND2 ND2 ND2 Type1 Allosteric Allosteric Allosteric 163 - 459 None X345,X346 6
6TIAB 2.52 Inactive DFGin BLAminus in-out in-in ND2 ND2 ND2 ND2 Type1 Allosteric Allosteric Allosteric 164 - 459 None X345,X346 6
5T1SB 2.3 Active DFGin BLAminus in-in in-in 76Q Type1.5_Back 161 - 459 None X342,X345,X346 5
2NRYA 2.15 Inactive DFGin BLBminus in-in in-in STU Type1 164 - 458 None X345 5
2NRYB 2.15 Inactive DFGin BLBminus in-out in-in STU Type1 164 - 458 None X345 5
6EGFB 2.61 Inactive DFGin BLBtrans out-out out-none ANP Type1 164 - 460 None None 12
4U97B 2.65 Inactive DFGin None in-in none-out STU Type1 166 - 458 D311N None 12
4U9AB 2.8 Inactive DFGin None in-in none-out STU Type1 166 - 458 D311N None 12
6EG9A 2.414 Inactive DFGout None in-out none-in 0LI Type2 164 - 459 None None 17
6EG9B 2.414 Inactive DFGout None in-in none-in 0LI Type2 165 - 459 None None 18
6EGAA 2.512 Inactive DFGout None in-in none-in J8A Type2 166 - 459 None None 18
6EGAB 2.512 Inactive DFGout None in-in none-in J8A Type2 164 - 459 None None 18
2O8YA 2.4 Inactive None None in-out in-in No_ligand No_ligand 165 - 459 None X342,X345 5
2O8YB 2.4 Inactive None None in-out in-in No_ligand No_ligand 165 - 459 None X342,X345 4
5KX7A 2.8 Inactive None None none-none in-in No_ligand No_ligand 192 - 459 None X342,X345,X346 4

IRAK4 (Interleukin-1 receptor-associated kinase 4)

Group: TKL
Total number of chains: 209
Spatial Dihedral Chains Representative
DFGin BLAminus 197 AF-Q9NWZ3-K1A
DFGin BLBminus 2 2NRYA
DFGin BLBtrans 1 6EGFB
DFGin None 2 4U97B
DFGout None 4 6EG9A
None None 3 2O8YA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens IRAK4_HUMAN 7C2WA 3.2 Inactive DFGin BLAminus in-out in-in YTH FJ9 Allosteric Type1 164 - 458 None X346 0
Homo sapiens IRAK4_HUMAN 7C2WB 3.2 Inactive DFGin BLAminus in-out in-in YTH FJ9 Allosteric Type1 163 - 458 None X346 0
Homo sapiens IRAK4_HUMAN 7C2WC 3.2 Inactive DFGin BLAminus in-out in-in YTH FJ9 Allosteric Type1 164 - 458 None X346 0
Homo sapiens IRAK4_HUMAN 7C2WD 3.2 Inactive DFGin BLAminus in-out in-in YTH FJ9 Allosteric Type1 164 - 458 None X346 0
Homo sapiens IRAK4_HUMAN AF-Q9NWZ3-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 167 - 460 None None 0
Homo sapiens IRAK4_HUMAN 2OIBA 2.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 162 - 458 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 2OIBB 2.0 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 164 - 459 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 2OIBC 2.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 161 - 458 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 2OIBD 2.0 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 162 - 459 None X342,X345,X346 0
Homo sapiens IRAK4_HUMAN 6F3DA 2.38 Inactive DFGin BLAminus in-out in-in CJT Type1 164 - 458 None X345,X346 7
Homo sapiens IRAK4_HUMAN 6F3DB 2.38 Inactive DFGin BLAminus in-out in-in CJT Type1 164 - 458 None X345,X346 7
Homo sapiens IRAK4_HUMAN 6F3EA 2.67 None DFGin BLAminus in-out none-in CJQ Type1 164 - 458 None X342,X345 8
Homo sapiens IRAK4_HUMAN 6F3EB 2.67 Inactive DFGin BLAminus in-out in-in CJQ Type1 164 - 458 None X342,X345 5
Homo sapiens IRAK4_HUMAN 6F3GA 2.37 Active DFGin BLAminus in-in in-in CJN Type1 164 - 458 None X342,X345,X346 6
Homo sapiens IRAK4_HUMAN 6F3GB 2.37 Active DFGin BLAminus in-in in-in CJN Type1 164 - 458 None X345,X346 6
Homo sapiens IRAK4_HUMAN 6N8GA 2.0 Active DFGin BLAminus in-in in-in KFD Type1 164 - 459 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 6N8GB 2.0 Inactive DFGin BLAminus in-out in-in KFD Type1 164 - 459 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 6N8GC 2.0 Active DFGin BLAminus in-in in-in KFD Type1 164 - 459 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 6N8GD 2.0 Active DFGin BLAminus in-in in-in KFD Type1 164 - 459 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 8BR5AAA 2.7 Inactive DFGin BLAminus in-out in-in R73 Type1 163 - 459 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 8BR5BBB 2.7 Inactive DFGin BLAminus in-out in-in R73 Type1 162 - 459 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 8BR5CCC 2.7 Inactive DFGin BLAminus in-out in-in R73 Type1 163 - 459 None X342,X345,X346 6
Homo sapiens IRAK4_HUMAN 8BR5DDD 2.7 Inactive DFGin BLAminus in-out in-in R73 Type1 164 - 459 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 7C2VA 2.44 Active DFGin BLAminus in-in in-in FJ0 Type1 163 - 459 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 7C2VB 2.44 Active DFGin BLAminus in-in in-in FJ0 Type1 162 - 459 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 7C2VC 2.44 Active DFGin BLAminus in-in in-in FJ0 Type1 164 - 460 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 7C2VD 2.44 Active DFGin BLAminus in-in in-in FJ0 Type1 164 - 459 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 2OICA 2.4 Active DFGin BLAminus in-in in-in STU Type1 163 - 458 None X342,X345,X346 6
Homo sapiens IRAK4_HUMAN 2OICB 2.4 Active DFGin BLAminus in-in in-in STU Type1 164 - 459 None X342,X345,X346 6
Homo sapiens IRAK4_HUMAN 2OICC 2.4 None DFGin BLAminus in-in none-in STU Type1 161 - 458 None X342,X345,X346 10
Homo sapiens IRAK4_HUMAN 2OICD 2.4 Active DFGin BLAminus in-in in-in STU Type1 161 - 459 None X342,X345,X346 2
Homo sapiens IRAK4_HUMAN 2OIDA 2.3 Inactive DFGin BLAminus out-out in-in ANP Type1 164 - 458 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 2OIDB 2.3 Inactive DFGin BLAminus in-out in-in ANP Type1 164 - 459 None X342,X345,X346 6
Homo sapiens IRAK4_HUMAN 2OIDC 2.3 Inactive DFGin BLAminus in-out in-in ANP Type1 166 - 458 None X342,X345,X346 6
Homo sapiens IRAK4_HUMAN 2OIDD 2.3 Active DFGin BLAminus in-in in-in ANP Type1 164 - 459 None X342,X345,X346 3
Homo sapiens IRAK4_HUMAN 4XS2A 2.73 Inactive DFGin BLAminus in-out in-in 42P Type1 163 - 459 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 4XS2B 2.73 Active DFGin BLAminus in-in in-in 42P Type1 161 - 459 None X342,X345,X346 7
Homo sapiens IRAK4_HUMAN 4XS2C 2.73 Inactive DFGin BLAminus in-out in-in 42P Type1 164 - 460 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 4XS2D 2.73 Inactive DFGin BLAminus in-out in-in 42P Type1 164 - 459 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 4YO6A 2.32 Inactive DFGin BLAminus in-out in-in 4GD Type1 163 - 459 None X342,X345,X346 3
Homo sapiens IRAK4_HUMAN 4YO6B 2.32 Active DFGin BLAminus in-in in-in 4GD Type1 161 - 459 None X342,X345,X346 6
Homo sapiens IRAK4_HUMAN 4YO6C 2.32 Inactive DFGin BLAminus in-out in-in 4GD Type1 164 - 460 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 4YP8A 2.641 Active DFGin BLAminus in-in in-in 4GF Type1 164 - 459 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 4YP8B 2.641 Inactive DFGin BLAminus in-out in-in 4GF Type1 161 - 459 None X342,X345,X346 6
Homo sapiens IRAK4_HUMAN 4YP8C 2.641 Inactive DFGin BLAminus in-out in-in 4GF Type1 164 - 460 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 4YP8D 2.641 Inactive DFGin BLAminus in-out in-in 4GF Type1 164 - 459 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 4ZTLA 2.39 Active DFGin BLAminus in-in in-in 4S1 Type1 165 - 459 None X342,X345,X346 7
Homo sapiens IRAK4_HUMAN 4ZTLB 2.39 Active DFGin BLAminus in-in in-in 4S1 Type1 165 - 459 None X342,X345,X346 6
Homo sapiens IRAK4_HUMAN 4ZTLC 2.39 Active DFGin BLAminus in-in in-in 4S1 Type1 164 - 460 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 4ZTLD 2.39 Inactive DFGin BLAminus in-out in-in 4S1 Type1 164 - 460 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 4ZTMA 2.66 Active DFGin BLAminus in-in in-in 4S2 Type1 162 - 459 None X342,X345,X346 3
Homo sapiens IRAK4_HUMAN 4ZTMB 2.66 Active DFGin BLAminus in-in in-in 4S2 Type1 161 - 459 None X342,X345,X346 6
Homo sapiens IRAK4_HUMAN 4ZTMC 2.66 Inactive DFGin BLAminus in-out in-in 4S2 Type1 164 - 460 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 4ZTMD 2.66 Active DFGin BLAminus in-in in-in 4S2 Type1 164 - 459 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 4ZTNA 2.23 Inactive DFGin BLAminus in-out in-in 4S3 Type1 163 - 459 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 4ZTNB 2.23 Active DFGin BLAminus in-in in-in 4S3 Type1 161 - 459 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 4ZTNC 2.23 Inactive DFGin BLAminus in-out in-in 4S3 Type1 164 - 460 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 4ZTND 2.23 Inactive DFGin BLAminus in-out in-in 4S3 Type1 164 - 459 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 5K72A 2.22 Active DFGin BLAminus in-in in-in 6QY Type1 164 - 458 None X345,X346 7
Homo sapiens IRAK4_HUMAN 5K72B 2.22 Active DFGin BLAminus in-in in-in 6QY Type1 165 - 458 None X345,X346 14
Homo sapiens IRAK4_HUMAN 5K72C 2.22 Active DFGin BLAminus in-in in-in 6QY Type1 164 - 458 None X345,X346 7
Homo sapiens IRAK4_HUMAN 5K72D 2.22 Active DFGin BLAminus in-in in-in 6QY Type1 164 - 458 None X345,X346 7
Homo sapiens IRAK4_HUMAN 5K75A 2.03 Active DFGin BLAminus in-in in-in 6QX Type1 164 - 458 None X345,X346 8
Homo sapiens IRAK4_HUMAN 5K75B 2.03 Inactive DFGin BLAminus in-out in-in 6QX Type1 163 - 458 None X345,X346 6
Homo sapiens IRAK4_HUMAN 5K75C 2.03 Inactive DFGin BLAminus in-out in-in 6QX Type1 164 - 458 None X345,X346 6
Homo sapiens IRAK4_HUMAN 5K75D 2.03 Inactive DFGin BLAminus in-out in-in 6QX Type1 164 - 458 None X345,X346 5
Homo sapiens IRAK4_HUMAN 5K76A 2.74 Inactive DFGin BLAminus in-out in-in 6R1 Type1 165 - 458 None X345,X346 6
Homo sapiens IRAK4_HUMAN 5K76B 2.74 Active DFGin BLAminus in-in in-in 6R1 Type1 164 - 458 None X345,X346 7
Homo sapiens IRAK4_HUMAN 5K7GA 2.23 Active DFGin BLAminus in-in in-in 6R0 Type1 164 - 458 None X345,X346 7
Homo sapiens IRAK4_HUMAN 5K7GB 2.23 Active DFGin BLAminus in-in in-in 6R0 Type1 165 - 458 None X345,X346 14
Homo sapiens IRAK4_HUMAN 5K7GC 2.23 Active DFGin BLAminus in-in in-in 6R0 Type1 164 - 458 None X345,X346 7
Homo sapiens IRAK4_HUMAN 5K7GD 2.23 Active DFGin BLAminus in-in in-in 6R0 Type1 164 - 458 None X345,X346 7
Homo sapiens IRAK4_HUMAN 5K7IA 2.31 Active DFGin BLAminus in-in in-in 6QZ Type1 164 - 458 None X345,X346 7
Homo sapiens IRAK4_HUMAN 5K7IB 2.31 Active DFGin BLAminus in-in in-in 6QZ Type1 164 - 458 None X345,X346 7
Homo sapiens IRAK4_HUMAN 5KX7B 2.8 Active DFGin BLAminus in-in in-in 6YD Type1 163 - 459 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 5KX8A 2.671 Active DFGin BLAminus in-in in-in 6YE Type1 163 - 459 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 5KX8B 2.671 Active DFGin BLAminus in-in in-in 6YE Type1 161 - 459 None X342,X345,X346 6
Homo sapiens IRAK4_HUMAN 5KX8C 2.671 Inactive DFGin BLAminus in-out in-in 6YE Type1 164 - 460 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 5KX8D 2.671 Active DFGin BLAminus in-in in-in 6YE Type1 164 - 459 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 5T1SA 2.3 Inactive DFGin BLAminus in-out in-in 76Q Type1 163 - 459 None X342,X345,X346 3
Homo sapiens IRAK4_HUMAN 5T1SC 2.3 Inactive DFGin BLAminus in-out in-in 76Q Type1 164 - 460 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 5T1SD 2.3 Active DFGin BLAminus in-in in-in 76Q Type1 164 - 459 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 5T1TA 2.34 Inactive DFGin BLAminus in-out in-in 76P Type1 163 - 459 None X342,X345,X346 6
Homo sapiens IRAK4_HUMAN 5T1TB 2.34 Inactive DFGin BLAminus in-out in-in 76P Type1 161 - 459 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 5T1TC 2.34 Inactive DFGin BLAminus in-out in-in 76P Type1 164 - 460 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 5T1TD 2.34 Inactive DFGin BLAminus in-out in-in 76P Type1 164 - 459 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 4Y73A 2.14 Inactive DFGin BLAminus in-out in-in XPY Type1 163 - 459 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 4Y73B 2.14 Inactive DFGin BLAminus in-out in-in XPY Type1 161 - 459 None X342,X345,X346 7
Homo sapiens IRAK4_HUMAN 4Y73C 2.14 Inactive DFGin BLAminus in-out in-in XPY Type1 164 - 460 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 4Y73D 2.14 Active DFGin BLAminus in-in in-in XPY Type1 164 - 459 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 6MOMA 2.1 Active DFGin BLAminus in-in in-in JX4 Type1 164 - 460 None X342,X345,X346 3
Homo sapiens IRAK4_HUMAN 6MOMB 2.1 Inactive DFGin BLAminus in-out in-in JX4 Type1 164 - 459 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 6MOMC 2.1 Active DFGin BLAminus in-in in-in JX4 Type1 163 - 460 None X342,X345,X346 3
Homo sapiens IRAK4_HUMAN 6MOMD 2.1 Inactive DFGin BLAminus in-out in-in JX4 Type1 164 - 459 None X342,X345,X346 0
Homo sapiens IRAK4_HUMAN 6O8UA 1.8 Inactive DFGin BLAminus in-out in-in LS7 Type1 164 - 458 None X345,X346 6
Homo sapiens IRAK4_HUMAN 6O8UB 1.8 Inactive DFGin BLAminus in-out in-in LS7 Type1 160 - 458 None X345,X346 7
Homo sapiens IRAK4_HUMAN 6O8UC 1.8 Inactive DFGin BLAminus in-out in-in LS7 Type1 163 - 458 None X345,X346 4
Homo sapiens IRAK4_HUMAN 6O8UD 1.8 Inactive DFGin BLAminus in-out in-in LS7 Type1 162 - 458 None X345,X346 6
Homo sapiens IRAK4_HUMAN 5W84A 2.9 Active DFGin BLAminus in-in in-in 9YY Type1 165 - 459 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 5W84B 2.9 None DFGin BLAminus in-none in-in 9YY Type1 168 - 459 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 5W85A 2.25 Inactive DFGin BLAminus in-out in-in 9YS Type1 164 - 458 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 5W85B 2.25 Inactive DFGin BLAminus in-out in-in 9YS Type1 164 - 459 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 6LXYA 2.19 Inactive DFGin BLAminus in-out in-in EXF Type1 163 - 458 None X345,X346 2
Homo sapiens IRAK4_HUMAN 6LXYB 2.19 None DFGin BLAminus in-none in-in EXF Type1 163 - 459 None X345,X346 0
Homo sapiens IRAK4_HUMAN 6LXYD 2.19 Inactive DFGin BLAminus in-out in-in EXF Type1 162 - 459 None X345,X346 5
Homo sapiens IRAK4_HUMAN 6LXYE 2.19 Inactive DFGin BLAminus in-out in-in EXF Type1 164 - 458 None X345,X346 7
Homo sapiens IRAK4_HUMAN 6VQLA 2.069 Inactive DFGin BLAminus in-out in-in R7S Type1 162 - 458 None X342,X345,X346 6
Homo sapiens IRAK4_HUMAN 6VQLB 2.069 Inactive DFGin BLAminus in-out in-in R7S Type1 163 - 458 None X342,X345,X346 6
Homo sapiens IRAK4_HUMAN 6VQLC 2.069 Inactive DFGin BLAminus in-out in-in R7S Type1 163 - 458 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 6VQLD 2.069 Inactive DFGin BLAminus in-out in-in R7S Type1 164 - 458 None X342,X345,X346 3
Homo sapiens IRAK4_HUMAN 2NRUA 2.0 Inactive DFGin BLAminus in-out in-in T12 Type1 164 - 458 None X345,X346 0
Homo sapiens IRAK4_HUMAN 2NRUB 2.0 Inactive DFGin BLAminus in-out in-in T12 Type1 163 - 458 None X345,X346 0
Homo sapiens IRAK4_HUMAN 2NRUC 2.0 Inactive DFGin BLAminus in-out in-in T12 Type1 164 - 458 None X345,X346 0
Homo sapiens IRAK4_HUMAN 2NRUD 2.0 Inactive DFGin BLAminus in-out in-in T12 Type1 164 - 458 None X345,X346 0
Homo sapiens IRAK4_HUMAN 2NRYC 2.15 Active DFGin BLAminus in-in in-in STU Type1 164 - 458 None X345 4
Homo sapiens IRAK4_HUMAN 2NRYD 2.15 Active DFGin BLAminus in-in in-in STU Type1 164 - 460 None X345 5
Homo sapiens IRAK4_HUMAN 4RMZA 2.2 Inactive DFGin BLAminus in-out in-in T20 Type1 165 - 458 None X342,X345,X346 3
Homo sapiens IRAK4_HUMAN 4RMZB 2.2 Inactive DFGin BLAminus in-out in-in T20 Type1 165 - 458 None X342,X345,X346 6
Homo sapiens IRAK4_HUMAN 6THWA 2.44 Inactive DFGin BLAminus in-out in-in NBK Type1 164 - 458 None None 12
Homo sapiens IRAK4_HUMAN 6THWB 2.44 Inactive DFGin BLAminus in-out in-in NBK Type1 164 - 458 None None 11
Homo sapiens IRAK4_HUMAN 6THXA 1.99 Active DFGin BLAminus in-in in-in N9Z Type1 164 - 458 None X345,X346 6
Homo sapiens IRAK4_HUMAN 6THXB 1.99 Inactive DFGin BLAminus in-out in-in N9Z Type1 164 - 458 None X345,X346 5
Homo sapiens IRAK4_HUMAN 6THZA 2.38 Active DFGin BLAminus in-in in-in NB5 Type1 165 - 458 None X345,X346 6
Homo sapiens IRAK4_HUMAN 6THZB 2.38 Inactive DFGin BLAminus in-out in-in NB5 Type1 164 - 458 None X345,X346 5
Homo sapiens IRAK4_HUMAN 6TI8A 2.32 Active DFGin BLAminus in-in in-in NBW Type1 165 - 459 None X345,X346 6
Homo sapiens IRAK4_HUMAN 6TI8B 2.32 Active DFGin BLAminus in-in in-in NBW Type1 165 - 459 None X345,X346 7
Homo sapiens IRAK4_HUMAN 6TI8C 2.32 Active DFGin BLAminus in-in in-in NBW Type1 164 - 459 None X345,X346 7
Homo sapiens IRAK4_HUMAN 6TI8D 2.32 Active DFGin BLAminus in-in in-in NBW Type1 164 - 458 None X345,X346 7
Homo sapiens IRAK4_HUMAN 7QG2A 3.031 Inactive DFGin BLAminus in-out in-in B6I Type1 164 - 458 None X345,X346 6
Homo sapiens IRAK4_HUMAN 7QG2B 3.031 Inactive DFGin BLAminus in-out in-in B6I Type1 165 - 458 None X345,X346 8
Homo sapiens IRAK4_HUMAN 7QG2C 3.031 Inactive DFGin BLAminus in-out in-in B6I Type1 164 - 458 None X345,X346 7
Homo sapiens IRAK4_HUMAN 7QG2D 3.031 Inactive DFGin BLAminus in-out in-in B6I Type1 164 - 458 None X345,X346 7
Homo sapiens IRAK4_HUMAN 7QG3A 2.11 Active DFGin BLAminus in-in in-in B4U Type1 164 - 458 None X342,X345,X346 6
Homo sapiens IRAK4_HUMAN 7QG3B 2.11 Inactive DFGin BLAminus in-out in-in B4U Type1 164 - 458 None X342,X345,X346 6
Homo sapiens IRAK4_HUMAN 7QG5A 2.3 Inactive DFGin BLAminus in-out in-in B7R Type1 165 - 458 None X345,X346 6
Homo sapiens IRAK4_HUMAN 7QG5B 2.3 Inactive DFGin BLAminus in-out in-in B7R Type1 164 - 458 None X345,X346 6
Homo sapiens IRAK4_HUMAN 6O94A 1.98 Inactive DFGin BLAminus in-out in-in LRS Type1 163 - 458 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 6O94B 1.98 Inactive DFGin BLAminus in-out in-in LRS Type1 162 - 458 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 6O94C 1.98 Inactive DFGin BLAminus in-out in-in LRS Type1 163 - 458 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 6O94D 1.98 Inactive DFGin BLAminus in-out in-in LRS Type1 163 - 458 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 6O95A 1.77 Inactive DFGin BLAminus in-out in-in LSV Type1 162 - 459 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 6O95B 1.77 Inactive DFGin BLAminus in-out in-in LSV Type1 163 - 458 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 6O95C 1.77 Inactive DFGin BLAminus in-out in-in LSV Type1 165 - 458 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 6O95D 1.77 Inactive DFGin BLAminus in-out in-in LSV Type1 161 - 458 None X342,X345,X346 6
Homo sapiens IRAK4_HUMAN 6O9DA 2.51 Inactive DFGin BLAminus in-out in-in LTY Type1 162 - 458 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 6O9DB 2.51 Inactive DFGin BLAminus in-out in-in LTY Type1 163 - 458 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 6O9DC 2.51 Active DFGin BLAminus in-in in-in LTY Type1 163 - 458 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 6O9DD 2.51 Inactive DFGin BLAminus in-out in-in LTY Type1 164 - 458 None X342,X345,X346 3
Homo sapiens IRAK4_HUMAN 6UYAA 1.74 Inactive DFGin BLAminus in-out in-in QL7 Type1 163 - 458 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 6UYAB 1.74 Inactive DFGin BLAminus in-out in-in QL7 Type1 165 - 458 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 6UYAC 1.74 Active DFGin BLAminus in-in in-in QL7 Type1 162 - 458 None X342,X345,X346 6
Homo sapiens IRAK4_HUMAN 6UYAD 1.74 Inactive DFGin BLAminus in-out in-in QL7 Type1 162 - 458 None X342,X345,X346 6
Homo sapiens IRAK4_HUMAN 6F3IA 2.14 Inactive DFGin BLAminus in-out in-in CKN Type1 165 - 458 None X345,X346 7
Homo sapiens IRAK4_HUMAN 6F3IB 2.14 Inactive DFGin BLAminus in-out in-in CKN Type1 164 - 458 None X345,X346 7
Homo sapiens IRAK4_HUMAN 6RFIA 2.31 Inactive DFGin BLAminus in-out in-in K1H Type1 165 - 458 None X345,X346 5
Homo sapiens IRAK4_HUMAN 6RFIB 2.31 Inactive DFGin BLAminus in-out in-in K1H Type1 164 - 458 None X345,X346 8
Homo sapiens IRAK4_HUMAN 6RFJA 2.61 Inactive DFGin BLAminus in-out in-in K1E Type1 165 - 458 None X345,X346 7
Homo sapiens IRAK4_HUMAN 6RFJB 2.61 Inactive DFGin BLAminus in-out in-in K1E Type1 164 - 458 None X345,X346 8
Homo sapiens IRAK4_HUMAN 7QG1A 2.07 Inactive DFGin BLAminus in-out in-in B8I Type1 165 - 458 None X345,X346 7
Homo sapiens IRAK4_HUMAN 7QG1B 2.07 Inactive DFGin BLAminus in-out in-in B8I Type1 164 - 458 None X345,X346 7
Homo sapiens IRAK4_HUMAN 5UIQA 2.64 Inactive DFGin BLAminus in-out in-in 8BV Type1 164 - 459 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 5UIQB 2.64 Inactive DFGin BLAminus in-out in-in 8BV Type1 164 - 458 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 5UIQC 2.64 Inactive DFGin BLAminus in-out in-in 8BV Type1 164 - 458 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 5UIQD 2.64 Inactive DFGin BLAminus in-out in-in 8BV Type1 164 - 458 None X342,X345,X346 6
Homo sapiens IRAK4_HUMAN 5UIRA 2.64 Inactive DFGin BLAminus in-out in-in 8BY Type1 165 - 458 None X342,X345,X346 8
Homo sapiens IRAK4_HUMAN 5UIRB 2.64 Inactive DFGin BLAminus in-out in-in 8BY Type1 164 - 458 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 5UISA 2.5 Inactive DFGin BLAminus in-out in-in 8C1 Type1 165 - 458 None X342,X345 8
Homo sapiens IRAK4_HUMAN 5UISB 2.5 Inactive DFGin BLAminus in-out in-in 8C1 Type1 165 - 458 None X342,X345 7
Homo sapiens IRAK4_HUMAN 5UISC 2.5 Inactive DFGin BLAminus in-out in-in 8C1 Type1 162 - 458 None X342,X345 8
Homo sapiens IRAK4_HUMAN 5UISD 2.5 Inactive DFGin BLAminus in-out in-in 8C1 Type1 165 - 458 None X342,X345 8
Homo sapiens IRAK4_HUMAN 5UITA 1.84 Inactive DFGin BLAminus in-out in-in 8CD Type1 162 - 458 None X345,X346 5
Homo sapiens IRAK4_HUMAN 5UITB 1.84 Inactive DFGin BLAminus in-out in-in 8CD Type1 164 - 458 None X345,X346 5
Homo sapiens IRAK4_HUMAN 5UIUA 2.02 Inactive DFGin BLAminus in-out in-in 8CG Type1 165 - 458 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 5UIUB 2.02 Inactive DFGin BLAminus in-out in-in 8CG Type1 164 - 458 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 8ATBAAA 2.35 Inactive DFGin BLAminus in-out in-in O0H Type1 165 - 459 K400A,E401A,E402A X345,X346 8
Homo sapiens IRAK4_HUMAN 8ATBBBB 2.35 Inactive DFGin BLAminus in-out in-in O0H Type1 165 - 459 K400A,E401A,E402A X345,X346 6
Homo sapiens IRAK4_HUMAN 8ATLAAA 2.464 Active DFGin BLAminus in-in in-in O6X Type1 165 - 459 K400A,E401A,E402A X345,X346 7
Homo sapiens IRAK4_HUMAN 8ATLBBB 2.464 Active DFGin BLAminus in-in in-in O6X Type1 165 - 459 K400A,E401A,E402A X345,X346 7
Homo sapiens IRAK4_HUMAN 8ATNAAA 2.171 Inactive DFGin BLAminus in-out in-in O06 Type1 165 - 459 K400A,E401A,E402A X345,X346 5
Homo sapiens IRAK4_HUMAN 8ATNBBB 2.171 Inactive DFGin BLAminus in-out in-in O06 Type1 165 - 459 K400A,E401A,E402A X345,X346 3
Homo sapiens IRAK4_HUMAN 8BR6AAA 2.167 Inactive DFGin BLAminus in-out in-in R6I Type1 165 - 459 K400A,E401A,E402A X345,X346 7
Homo sapiens IRAK4_HUMAN 8BR6BBB 2.167 Inactive DFGin BLAminus in-out in-in R6I Type1 165 - 459 K400A,E401A,E402A X345,X346 6
Homo sapiens IRAK4_HUMAN 8BR7AAA 2.119 Inactive DFGin BLAminus in-out in-in R6R Type1 165 - 458 K400A,E401A,E402A X345,X346 6
Homo sapiens IRAK4_HUMAN 8BR7BBB 2.119 Inactive DFGin BLAminus in-out in-in R6R Type1 165 - 458 K400A,E401A,E402A X345,X346 5
Homo sapiens IRAK4_HUMAN 8DKSA 2.45 Inactive DFGin BLAminus in-out in-in SO9 Type1 165 - 459 None X346 7
Homo sapiens IRAK4_HUMAN 8DKSB 2.45 Inactive DFGin BLAminus in-out in-in SO9 Type1 164 - 459 None X346 6
Homo sapiens IRAK4_HUMAN 8WTFA 2.0 Inactive DFGin BLAminus in-out in-in 8CG Type1 165 - 458 None None 0
Homo sapiens IRAK4_HUMAN 6EGDA 2.1 None DFGin BLAminus in-in in-none J87 Type1 165 - 458 None None 16
Homo sapiens IRAK4_HUMAN 6EGDD 2.1 None DFGin BLAminus in-out in-none J87 Type1 164 - 458 None None 16
Homo sapiens IRAK4_HUMAN 6EGEA 1.401 Active DFGin BLAminus in-in in-in DL1 Type1 165 - 459 None None 11
Homo sapiens IRAK4_HUMAN 6EGED 1.401 None DFGin BLAminus in-in in-none DL1 Type1 164 - 457 None None 5
Homo sapiens IRAK4_HUMAN 4U97A 2.65 None DFGin BLAminus in-in none-in STU Type1 166 - 458 D311N None 8
Homo sapiens IRAK4_HUMAN 4U9AA 2.8 None DFGin BLAminus in-in none-in STU Type1 166 - 458 D311N None 8
Homo sapiens IRAK4_HUMAN 4YO6D 2.32 Inactive DFGin BLAminus in-out in-in 4GD 4GD Type1 Allosteric 164 - 459 None X342,X345,X346 4
Homo sapiens IRAK4_HUMAN 6TIAA 2.52 Inactive DFGin BLAminus in-out in-in ND2 ND2 ND2 ND2 Type1 Allosteric Allosteric Allosteric 163 - 459 None X345,X346 6
Homo sapiens IRAK4_HUMAN 6TIAB 2.52 Inactive DFGin BLAminus in-out in-in ND2 ND2 ND2 ND2 Type1 Allosteric Allosteric Allosteric 164 - 459 None X345,X346 6
Homo sapiens IRAK4_HUMAN 5T1SB 2.3 Active DFGin BLAminus in-in in-in 76Q Type1.5_Back 161 - 459 None X342,X345,X346 5
Homo sapiens IRAK4_HUMAN 2NRYA 2.15 Inactive DFGin BLBminus in-in in-in STU Type1 164 - 458 None X345 5
Homo sapiens IRAK4_HUMAN 2NRYB 2.15 Inactive DFGin BLBminus in-out in-in STU Type1 164 - 458 None X345 5
Homo sapiens IRAK4_HUMAN 6EGFB 2.61 Inactive DFGin BLBtrans out-out out-none ANP Type1 164 - 460 None None 12
Homo sapiens IRAK4_HUMAN 4U97B 2.65 Inactive DFGin None in-in none-out STU Type1 166 - 458 D311N None 12
Homo sapiens IRAK4_HUMAN 4U9AB 2.8 Inactive DFGin None in-in none-out STU Type1 166 - 458 D311N None 12
Homo sapiens IRAK4_HUMAN 6EG9A 2.414 Inactive DFGout None in-out none-in 0LI Type2 164 - 459 None None 17
Homo sapiens IRAK4_HUMAN 6EG9B 2.414 Inactive DFGout None in-in none-in 0LI Type2 165 - 459 None None 18
Homo sapiens IRAK4_HUMAN 6EGAA 2.512 Inactive DFGout None in-in none-in J8A Type2 166 - 459 None None 18
Homo sapiens IRAK4_HUMAN 6EGAB 2.512 Inactive DFGout None in-in none-in J8A Type2 164 - 459 None None 18
Homo sapiens IRAK4_HUMAN 2O8YA 2.4 Inactive None None in-out in-in No_ligand No_ligand 165 - 459 None X342,X345 5
Homo sapiens IRAK4_HUMAN 2O8YB 2.4 Inactive None None in-out in-in No_ligand No_ligand 165 - 459 None X342,X345 4
Homo sapiens IRAK4_HUMAN 5KX7A 2.8 Inactive None None none-none in-in No_ligand No_ligand 192 - 459 None X342,X345,X346 4

IRAK4 (Interleukin-1 receptor-associated kinase 4)

No non-human structures known.