6TIA

IRAK4 (Interleukin-1 receptor-associated kinase 4)
Group: TKL
Uniprot: IRAK4_HUMAN
Organism: Homo sapiens
Domain boundary: 175 - 456
Resolu: 2.52

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLAminus in-out in-in ND2 ND2 ND2 ND2 Type1 Allosteric Allosteric Allosteric 163 - 459 6
B Inactive DFGin BLAminus in-out in-in ND2 ND2 ND2 ND2 Type1 Allosteric Allosteric Allosteric 164 - 459 6
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
       162        172        182        192 
genkslevsd tRFHSFSFYE LKNVTNNFDE RPISVGGNKM 
       202        212        222        232 
GEGGFGVVYK GYVNNTTVAV KKLAAmvdIT TEELKQQFDQ 
       242        252        262        272 
EIKVMAKCQH ENLVELLGFS SDGDDLCLVY VYMPNGSLLD 
       282        292        302        312 
RLSCLDGTPP LSWHMRCKIA QGAANGINFL HENHHIHRDI 
       322        332        342        352 
KSANILLDEA FTAKISDFGL ARASekfaqt VMTSRIVGTT 
       362        372        382        392 
AYMAPEALRG EITPKSDIYS FGVVLLEIIT GLPAVDEHRE 
       402        412        422        432 
PQLLLDIKEE IEDEEKTIED YIDKKMNDAD STSVEAMYSV 
       442        452 
ASQCLHEKKN KRPDIKKVQQ LLQEMTAs
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: X345,X346