5W85

IRAK4 (Interleukin-1 receptor-associated kinase 4)
Group: TKL
Uniprot: IRAK4_HUMAN
Organism: Homo sapiens
Domain boundary: 175 - 456
Resolu: 2.25

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLAminus in-out in-in 9YS Type1 164 - 458 5
B Inactive DFGin BLAminus in-out in-in 9YS Type1 164 - 459 4
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
       165        175        185        195 
gamgvsdtRF HSFSFYELKN VTNNFDERPI SVGGNKMGEg 
       205        215        225        235 
gFGVVYKGYV NNTTVAVKKL aamvdittEE LKQQFDQEIK 
       245        255        265        275 
VMAKCQHENL VELLGFSSDG DDLCLVYVYM PNGSLLDRLS 
       285        295        305        315 
CLDGTPPLSW HMRCKIAQGA ANGINFLHEN HHIHRDIKSA 
       325        335        345        355 
NILLDEAFTA KISDFGLARA SekfaQTVMT SRIVGTTAYM 
       365        375        385        395 
APEALRGEIT PKSDIYSFGV VLLEIITGLP AVDEHREPQL 
       405        415        425        435 
LLDIKEEIED EEKTIEDYID KKMNDADSTS VEAMYSVASQ 
       445        455 
CLHEKKNKRP DIKKVQQLLQ EMTAs
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: X342,X345,X346