8BR7

IRAK4 (Interleukin-1 receptor-associated kinase 4)
Group: TKL
Uniprot: IRAK4_HUMAN
Organism: Homo sapiens
Domain boundary: 175 - 456
Resolu: 2.119

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
AAA Inactive DFGin BLAminus in-out in-in R6R Type1 165 - 458 6
BBB Inactive DFGin BLAminus in-out in-in R6R Type1 165 - 458 5
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain BBB
       172        182        192        202 
gsFHSFSFYE LKNVTNNFDE RPISVGGNKM GeggfGVVYK 
       212        222        232        242 
GYVNNTTVAV KKLaamvdit TEELKQQFDQ EIKVMAKCQH 
       252        262        272        282 
ENLVELLGFS SDGDDLCLVY VYMPNGSLLD RLSCLDGTPP 
       292        302        312        322 
LSWHMRCKIA QGAANGINFL HENHHIHRDI KSANILLDEA 
       332        342        352        362 
FTAKISDFGL ARASekfaqT VMTSRIVGTT AYMAPEALRG 
       372        382        392        402 
EITPKSDIYS FGVVLLEIIT GLPAVDEHRE PQLLLDIAAA 
       412        422        432        442 
IEDEEKTIED YIDKKMNDAD STSVEAMYSV ASQCLHEKKN 
       452 
KRPDIKKVQQ LLQEMTas
Lower-case residues are disordered in structure.
Mutations: K400A,E401A,E402A
Phosphorylation: X345,X346