Ligand: VGH (Crizotinib)

Total number of chains: 9
Active chains: 0
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 8 88.9% 5AAAA
DFGin BLBplus 1 11.1% 2WGJA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TYR ALK ALK_HUMAN 4ANSA 1.85 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao VGH Type1 1093 - 1402 0 None L1196M,G1269A ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 2YFXA 1.7 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao VGH Type1 1093 - 1401 0 None L1196M ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 4ANQA 1.76 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao VGH Type1 1093 - 1402 0 None G1269A ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 5AAAA 1.73 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao VGH Type1 1093 - 1401 0 None L1198F ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 5AABA 2.2 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao VGH Type1 1093 - 1402 0 None C1156Y,L1198F ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 2XP2A 1.9 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_niiai APEdist_aaao VGH Type1 1093 - 1401 0 None None ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 5AACA 1.7 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao VGH Type1 1093 - 1402 0 None C1156Y ALK tyrosine kinase receptor
TYR MET MET_HUMAN 2WGJA 2.0 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai VGH Type1 1052 - 1345 0 None None Hepatocyte growth factor receptor
TYR ROS1 ROS1_HUMAN 3ZBFA 2.2 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_nniai APEdist_aaao VGH Type1 1934 - 2230 0 None None Proto-oncogene tyrosine-protein kinase ROS

Ligand: VGH (Crizotinib)

Total number of chains: 9
Active chains: 0
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 8 88.9% 5AAAA
DFGin BLBplus 1 11.1% 2WGJA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYR ALK ALK_HUMAN 4ANSA 1.85 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao VGH Type1 1093 - 1402 0 None L1196M,G1269A ALK tyrosine kinase receptor Homo sapiens
TYR ALK ALK_HUMAN 2YFXA 1.7 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao VGH Type1 1093 - 1401 0 None L1196M ALK tyrosine kinase receptor Homo sapiens
TYR ALK ALK_HUMAN 4ANQA 1.76 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao VGH Type1 1093 - 1402 0 None G1269A ALK tyrosine kinase receptor Homo sapiens
TYR ALK ALK_HUMAN 5AAAA 1.73 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao VGH Type1 1093 - 1401 0 None L1198F ALK tyrosine kinase receptor Homo sapiens
TYR ALK ALK_HUMAN 5AABA 2.2 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao VGH Type1 1093 - 1402 0 None C1156Y,L1198F ALK tyrosine kinase receptor Homo sapiens
TYR ALK ALK_HUMAN 2XP2A 1.9 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_niiai APEdist_aaao VGH Type1 1093 - 1401 0 None None ALK tyrosine kinase receptor Homo sapiens
TYR ALK ALK_HUMAN 5AACA 1.7 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaao VGH Type1 1093 - 1402 0 None C1156Y ALK tyrosine kinase receptor Homo sapiens
TYR MET MET_HUMAN 2WGJA 2.0 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai VGH Type1 1052 - 1345 0 None None Hepatocyte growth factor receptor Homo sapiens
TYR ROS1 ROS1_HUMAN 3ZBFA 2.2 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_nniai APEdist_aaao VGH Type1 1934 - 2230 0 None None Proto-oncogene tyrosine-protein kinase ROS Homo sapiens

Ligand: VGH (Crizotinib)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism