STE_MAP2K7 (Dual specificity mitogen-activated protein kinase kinase 7)

Total number of chains: 42
Active chains: 5
Uniprot: MP2K7_HUMAN
Kinase Domain Residues: 120 - 380
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 15 35.7% 5Y90A
DFGin BLAminus 10 23.8% AF-O14733-K1A
DFGin None 7 16.7% 7OVNA
DFGin ABAminus 5 11.9% 6QFLA
DFGout BBAminus 2 4.8% 6YG7B
DFGin BLAplus 1 2.4% 7OVIA
DFGin BLBplus 1 2.4% 7OVJA
None None 1 2.4% 6YG2A

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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP2K7 AF-O14733-K1A O14733 112 388 419.0 No_ligand No_ligand Active DFGin 6.1518 12.8912 BLAminus -144.89, 179.02 60.87, 74.04 -92.3, 11.23 308.58, 103.72 -61.88, -23.93 in-na in 7.6157 Saltbr-na 2.6548 HRD-in -80.04, -46.28 68.18, 5.82 na-in-in SNCaii in-in ActLoopNT-in 2.8994 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -141.79, 153.26 APE9-dihe-na 72.6, 179.68 APE8-dihe-in -81.41, 127.53 APE8-rot-na 184.94 APE67-dihe-in -59.35, -26.49 -52.46, -39.21 APE12-dist-in 12.2883 APE11-dist-in 9.8685 APE10-dist-in 5.4411 APE9-dist-in 3.3372 None None None AF2 -1.0 1.0 1.0 A 277.0 277.0 0 27 27 0 [[120, 380]] 1.0 AF-O14733-K1 STE_MAP2K7_HUMAN STE 1.6e-80 276.1 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 AF-O14733-K3A O14733 112 388 419.0 No_ligand No_ligand Active DFGin 6.039 12.9631 BLAminus -142.81, 179.24 63.68, 76.23 -95.26, 8.18 307.0, 99.42 -58.85, -29.95 in-na in 7.7118 Saltbr-na 2.6849 HRD-in -74.82, -48.5 72.99, -4.88 na-in-in SNCaii in-in ActLoopNT-in 2.8916 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -119.76, 112.73 APE9-dihe-na 151.27, 162.54 APE8-dihe-in -75.49, 123.1 APE8-rot-na 183.03 APE67-dihe-in -55.59, -26.31 -51.09, -39.22 APE12-dist-in 12.3269 APE11-dist-in 10.2555 APE10-dist-in 4.9499 APE9-dist-in 4.1313 None None None AF2 -1.0 1.0 1.0 A 277.0 277.0 0 27 27 0 [[120, 380]] 1.0 AF-O14733-K3 STE_MAP2K7_HUMAN STE 1.6e-80 276.1 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 6YG1A O14733 86 404 419.0 No_ligand No_ligand Active DFGin 5.9305 14.6445 BLAminus -139.75, -178.51 55.48, 92.06 -111.01, 29.63 315.16, 93.19 -69.74, -26.75 in-na in 8.1105 Saltbr-na 3.0077 HRD-in -72.55, -50.64 76.96, 6.43 na-in-in SNCaii in-in ActLoopNT-in 2.9082 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -79.26, 103.62 APE9-dihe-na 136.94, 169.34 APE8-dihe-in -92.63, 126.44 APE8-rot-na 170.6 APE67-dihe-in -62.5, -26.78 -51.81, -44.28 APE12-dist-in 12.7902 APE11-dist-in 9.924 APE10-dist-in 5.3977 APE9-dist-in 3.4564 S271D,T275D None None XRAY 2.22 0.205 0.232 A 348.0 314.0 5 27 27 0 [[120, 380]] 1.0 6yg1 STE_MAP2K7_HUMAN STE 5.1e-80 274.6 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 6YG1B O14733 93 404 419.0 No_ligand No_ligand Active DFGin 5.8891 14.977 BLAminus -142.37, -179.59 56.42, 90.83 -110.86, 29.11 314.92, 97.64 -68.6, -26.26 in-na in 8.8917 Saltbr-na 4.9518 HRD-in -68.85, -52.56 75.41, 8.03 na-in-in SNCaii in-in ActLoopNT-in 2.9323 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -77.32, 102.16 APE9-dihe-na 141.15, 166.92 APE8-dihe-in -91.69, 124.38 APE8-rot-na 170.36 APE67-dihe-in -60.55, -28.59 -53.55, -45.43 APE12-dist-in 12.7222 APE11-dist-in 9.7884 APE10-dist-in 5.3121 APE9-dist-in 3.4756 S271D,T275D None None XRAY 2.22 0.205 0.232 B 348.0 307.0 5 27 27 0 [[120, 380]] 1.0 6yg1 STE_MAP2K7_HUMAN STE 5.1e-80 274.6 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 6YG1C O14733 86 405 419.0 No_ligand No_ligand Active DFGin 5.867 14.8801 BLAminus -143.88, 179.51 55.81, 91.73 -110.17, 29.88 314.81, 97.84 -67.15, -27.41 in-na in 8.669 Saltbr-na 3.7601 HRD-in -70.3, -52.02 75.96, 8.08 na-in-in SNCaii in-in ActLoopNT-in 2.9308 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -78.45, 102.93 APE9-dihe-na 140.93, 165.22 APE8-dihe-in -88.99, 125.59 APE8-rot-na 170.38 APE67-dihe-in -58.75, -28.89 -54.03, -43.27 APE12-dist-in 12.6582 APE11-dist-in 9.8249 APE10-dist-in 5.3379 APE9-dist-in 3.4565 S271D,T275D None None XRAY 2.22 0.205 0.232 C 348.0 315.0 5 27 27 0 [[120, 380]] 1.0 6yg1 STE_MAP2K7_HUMAN STE 5.1e-80 274.6 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 6QFLA O14733 102 402 419.0 No_ligand No_ligand Inactive DFGin 6.1869 15.5229 ABAminus -126.91, -56.87 -92.09, 122.12 -125.66, 36.65 313.06, 96.64 -68.73, -31.95 in-na in 9.0244 Saltbr-na 3.5267 HRD-in -77.84, -48.81 72.51, 6.74 na-in-out SNCaio in-out ActLoopNT-in 2.9872 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nnoi APE10-dihe-na 999.0, 153.08 APE9-dihe-na -74.6, -175.14 APE8-dihe-in -65.82, 132.42 APE8-rot-na 184.94 APE67-dihe-in -67.15, -27.95 -62.93, -24.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.0888 APE9-dist-in 3.62 None None None XRAY 2.2 0.217 0.247 A 318.0 287.0 14 27 18 9 [[120, 380]] 1.0 6qfl STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 6QFTA O14733 102 400 419.0 J0B:60501 Type1 Inactive DFGin 6.0919 14.6665 ABAminus -132.5, -47.39 -100.07, 114.73 -122.28, 26.64 317.67, 98.18 -69.72, -23.3 in-na in 8.4328 Saltbr-na 3.1711 HRD-in -71.0, -47.5 68.26, 12.64 na-in-none SNCain in-none ActLoopNT-in 2.8177 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -79.93 APE8-rot-na 305.39 APE67-dihe-in -84.39, -17.02 -72.51, -17.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.24 0.287 A 318.0 276.0 22 27 15 12 [[120, 380]] 1.0 6qft STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 6QG4A O14733 111 401 419.0 J0E:60501 Type1 Inactive DFGin 6.1822 15.1809 ABAminus -117.76, -64.0 -82.44, 121.85 -124.1, 34.74 316.86, 109.91 -70.66, -23.17 in-na in 8.8168 Saltbr-na 4.4158 HRD-in -81.15, -52.15 67.31, 24.06 na-in-none SNCain in-none ActLoopNT-in 3.0048 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -96.03, 10.82 999.0, 49.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.236 0.269 A 318.0 264.0 27 27 14 13 [[120, 380]] 1.0 6qg4 STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 6QG7A O14733 102 401 419.0 6HL:60501 Type1 Inactive DFGin 5.9114 15.2319 ABAminus -123.01, -51.98 -107.12, 111.08 -111.71, 38.94 316.9, 98.78 -70.4, -27.38 in-na in 8.9966 Saltbr-na 5.5763 HRD-in -77.58, -50.11 69.18, 12.05 na-in-out SNCaio in-out ActLoopNT-in 2.9311 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nnoi APE10-dihe-na 999.0, 133.85 APE9-dihe-na -74.73, -170.49 APE8-dihe-in -66.48, 132.0 APE8-rot-na 174.14 APE67-dihe-in -67.76, -29.49 -64.52, -21.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.8645 APE9-dist-in 3.5369 None None None XRAY 2.1 0.236 0.268 A 318.0 282.0 18 27 18 9 [[120, 380]] 1.0 6qg7 STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 6QHOA O14733 111 401 419.0 J3H:60501 Type1 Inactive DFGin 6.151 14.841 ABAminus -134.48, -24.2 -123.38, 105.65 -115.94, 26.77 316.11, 97.72 -69.46, -18.96 in-na in 8.6446 Saltbr-na 2.9685 HRD-in -77.76, -54.43 71.88, 11.21 na-in-none SNCain in-none ActLoopNT-in 3.4399 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.226 0.281 A 318.0 266.0 25 27 12 15 [[120, 380]] 1.0 6qho STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 6IB0A O14733 101 400 419.0 H8Z:60501 Type1 Inactive DFGin 6.0991 14.9841 BLAminus -148.24, 171.72 65.71, 75.57 -92.89, 38.74 314.28, 84.61 -68.11, -29.03 in-na in 8.7408 Saltbr-na 4.0034 HRD-in -70.72, -53.16 74.59, 10.21 na-in-out SNCaio in-out ActLoopNT-in 3.2572 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nnoi APE10-dihe-na 999.0, 128.1 APE9-dihe-na -73.49, -154.36 APE8-dihe-in -71.53, 139.51 APE8-rot-na 175.13 APE67-dihe-in -66.31, -29.13 -74.24, -29.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.946 APE9-dist-in 3.7346 None None None XRAY 2.6 0.23 0.271 A 318.0 290.0 10 27 17 10 [[120, 380]] 1.0 6ib0 STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 6QHRA O14733 111 401 419.0 J3N:60501 Type1 Inactive DFGin 6.0896 15.3278 BLAminus -146.67, 176.67 62.9, 89.87 -111.41, 30.09 309.69, 89.26 -65.92, -26.31 in-na in 8.7379 Saltbr-na 3.5821 HRD-in -74.13, -47.12 71.22, 3.25 na-in-out SNCaio in-out ActLoopNT-in 2.897 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nnoi APE10-dihe-na 999.0, 133.41 APE9-dihe-na -75.58, -168.78 APE8-dihe-in -70.75, 132.36 APE8-rot-na 181.96 APE67-dihe-in -70.59, -23.34 -59.05, -27.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.9951 APE9-dist-in 3.8609 None None None XRAY 2.52 0.241 0.294 A 318.0 276.0 15 27 18 9 [[120, 380]] 1.0 6qhr STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 7OVIA O14733 102 402 419.0 2GI:60501 Type1.5_Front Inactive DFGin 4.7552 13.5989 BLAplus -140.91, 171.28 50.96, 52.63 -104.5, 0.42 42.65, 71.15 -92.35, -151.25 in-na in 9.7926 Saltbr-na 8.3457 HRD-out -95.23, 128.06 -114.34, -2.31 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.95 0.211 0.25 A 318.0 262.0 39 27 4 23 [[120, 380]] 1.0 7ovi STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 7OVJA O14733 102 403 419.0 24N:60501 Type1.5_Front Inactive DFGin 5.2382 14.0399 BLBplus -149.66, 173.75 53.03, 68.8 -120.16, 126.9 30.41, 81.15 125.32, 999.0 in-na in 9.4969 Saltbr-na 8.4026 HRD-in -63.57, -57.01 68.81, 21.85 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiai APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 162.2 APE8-dihe-in -71.05, 126.52 APE8-rot-na 187.98 APE67-dihe-in -67.38, -26.76 -67.11, -24.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.1906 None None None XRAY 2.35 0.204 0.244 A 318.0 276.0 26 27 12 15 [[120, 380]] 1.0 7ovj STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 5B2MA O14733 105 400 419.0 No_ligand No_ligand Inactive DFGin 9.579 19.7731 None -127.86, 134.8 -161.61, -89.86 49.84, 999.0 177.0, 80.04 999.0, 999.0 out-na out 12.7097 Saltbr-na 12.8043 HRD-in -62.81, -53.51 71.04, 8.99 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_nnno APE10-dihe-na 999.0, 42.27 APE9-dihe-na -108.06, 130.67 APE8-dihe-out -63.3, -33.92 APE8-rot-na 122.97 APE67-dihe-in -63.12, -24.65 -98.4, 12.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.8922 None None None XRAY 3.06 0.291 0.364 A 324.0 255.0 41 27 12 15 [[120, 380]] 1.0 5b2m STE_MAP2K7_HUMAN STE 2.9e-80 275.3 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 7OVLA O14733 102 402 419.0 1XZ:60501 Type1 Inactive DFGin 4.9356 14.7119 None -131.83, 135.57 1.69, 124.27 -119.89, 81.31 23.68, 77.2 -67.86, -14.37 in-na in 9.3478 Saltbr-na 999.0 HRD-in -75.58, -48.66 66.23, 10.91 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nnoi APE10-dihe-na 999.0, 161.45 APE9-dihe-na -75.62, -169.03 APE8-dihe-in -66.96, 129.78 APE8-rot-na 196.63 APE67-dihe-in -77.35, -36.68 -69.13, -18.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.6445 APE9-dist-in 3.4276 None None None XRAY 2.9 0.248 0.27 A 318.0 279.0 22 27 15 12 [[120, 380]] 1.0 7ovl STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 7OVMA O14733 102 402 419.0 21I:60501 Type1 Inactive DFGin 5.5693 14.8886 None -100.36, -115.13 -133.81, 137.4 -113.6, 82.88 349.67, 74.13 -90.73, -9.2 in-na in 9.611 Saltbr-na 4.2453 HRD-in -65.68, -55.04 65.08, 15.11 na-in-none SNCain in-none ActLoopNT-in 2.9245 ActLoopCT-none nonTYR APEdihe_aaiai APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 173.58 APE8-dihe-in -69.89, 133.33 APE8-rot-na 191.29 APE67-dihe-in -78.39, -27.08 -69.91, -12.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.3277 None None None XRAY 2.9 0.233 0.286 A 318.0 282.0 19 27 16 11 [[120, 380]] 1.0 7ovm STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 7OVNA O14733 102 402 419.0 2I8:60501 Type1 Inactive DFGin 4.9662 14.684 None -79.07, -108.85 -132.92, 129.36 -118.94, 86.57 14.8, 59.14 -92.78, -9.46 in-na in 8.7495 Saltbr-na 3.314 HRD-in -73.42, -49.75 66.93, 12.16 na-in-out SNCaio in-out ActLoopNT-in 2.7697 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nnoi APE10-dihe-na 999.0, 179.48 APE9-dihe-na -73.36, -177.84 APE8-dihe-in -62.31, 134.27 APE8-rot-na 205.08 APE67-dihe-in -72.39, -30.0 -65.21, -22.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.6301 APE9-dist-in 3.5925 None None None XRAY 2.9 0.225 0.257 A 318.0 283.0 18 27 17 10 [[120, 380]] 1.0 7ovn STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 9HZ0A O14733 101 401 419.0 A1IY7:60501 Type1 Inactive DFGin 5.7468 14.9744 None -112.81, -166.53 -54.75, 142.97 -115.5, 75.64 327.47, 81.17 -69.37, -28.6 in-na in 8.8354 Saltbr-na 999.0 HRD-in -68.14, -48.97 74.35, -1.92 na-in-none SNCain in-none ActLoopNT-in 2.9492 ActLoopCT-none nonTYR APEdihe_aaiai APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 140.19 APE8-dihe-in -74.03, 132.92 APE8-rot-na 185.24 APE67-dihe-in -65.54, -21.82 -64.33, -35.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.7967 None None None XRAY 2.25 0.223 0.263 A 318.0 278.0 23 27 15 12 [[120, 380]] 1.0 9hz0 STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 7OVKA O14733 102 401 419.0 2I5:60502 Type1.5_Back Inactive DFGin 5.7986 14.1308 None -146.4, 162.27 58.41, 85.98 -92.37, 999.0 319.32, 113.16 999.0, 999.0 in-na in 9.452 Saltbr-na 7.5825 HRD-in -63.92, -73.21 74.68, -0.77 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.05 0.217 0.244 A 318.0 256.0 44 27 2 25 [[120, 380]] 1.0 7ovk STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 6IB2A O14733 102 401 419.0 862:60501 Type1.5_Front Inactive DFGin 5.2764 14.0728 None -91.61, -76.02 -109.31, 164.08 -125.38, 999.0 315.5, 111.59 999.0, 999.0 in-na in 9.9266 Saltbr-na 8.3493 HRD-out -68.06, 100.79 -82.59, 24.57 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -28.73 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.224 0.25 A 318.0 265.0 35 27 8 19 [[120, 380]] 1.0 6ib2 STE_MAP2K7_HUMAN STE 3.1e-80 275.2 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 6YG7A O14733 102 403 419.0 OQ2:60504 Type2 Inactive DFGout 14.3068 9.3634 BBAminus -135.79, -174.49 -146.78, 99.14 -72.95, -12.7 271.17, 101.44 54.78, 27.39 out-na out 11.4547 Saltbr-na 10.3686 HRD-in -83.32, -61.5 88.57, -4.6 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanao APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 164.72 APE8-rot-na 77.42 APE67-dihe-out -154.57, 128.74 -105.88, 129.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S271D,T275D None None XRAY 2.2 0.209 0.251 A 307.0 278.0 24 27 12 15 [[120, 380]] 1.0 6yg7 STE_MAP2K7_HUMAN STE 3.3e-80 275.1 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 6YG7B O14733 103 403 419.0 OQ2:60501 Type2 Inactive DFGout 14.2314 9.1215 BBAminus -134.34, -173.96 -146.89, 101.17 -73.22, -11.42 272.26, 99.4 58.67, 31.18 out-na out 11.6145 Saltbr-na 10.5414 HRD-in -80.67, -58.84 84.82, -5.07 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 165.49 APE8-dihe-in -163.35, 172.69 APE8-rot-na 73.01 APE67-dihe-out -154.98, 128.01 -103.81, 131.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 20.3622 S271D,T275D None None XRAY 2.2 0.209 0.251 B 307.0 280.0 21 27 14 13 [[120, 380]] 1.0 6yg7 STE_MAP2K7_HUMAN STE 3.3e-80 275.1 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 6YZ4A O14733 101 404 419.0 1E8:60514 Allosteric Inactive DFGout 14.5151 13.0633 None -65.33, 150.4 -71.99, -22.54 -69.32, 117.0 179.71, 79.57 76.56, 9.7 in-na in 9.9774 Saltbr-na 5.7683 HRD-in -58.98, -51.27 69.96, 9.38 na-out-out SNCaoo out-out ActLoopNT-out 4.641 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 162.56 APE8-dihe-out -103.96, 46.58 APE8-rot-na 270.86 APE67-dihe-in -43.13, -49.42 -40.36, -39.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.5545 None None None XRAY 1.7 0.171 0.206 A 307.0 290.0 14 27 17 10 [[120, 380]] 1.0 6yz4 STE_MAP2K7_HUMAN STE 2.4e-80 275.5 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 5Y8UA O14733 103 402 419.0 No_ligand No_ligand Inactive DFGout 13.212 8.7971 None -105.43, 104.01 -75.1, 93.5 -77.42, 118.96 218.18, 57.42 -77.04, 145.42 out-na out 16.1698 Saltbr-na 15.7899 HRD-in -66.06, -43.39 62.31, 29.58 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_nnoo APE10-dihe-na 999.0, 107.71 APE9-dihe-na -104.74, 41.32 APE8-dihe-in -82.15, 94.45 APE8-rot-na 354.74 APE67-dihe-out -98.49, 44.79 63.11, 64.93 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 23.4742 APE9-dist-out 15.5681 C260S None None XRAY 2.92 0.234 0.299 A 323.0 267.0 33 27 14 13 [[120, 380]] 1.0 5y8u STE_MAP2K7_HUMAN STE 9.6e-80 273.6 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 5Y90A O14733 103 419 419.0 No_ligand No_ligand Inactive DFGout 14.4779 12.3818 None -68.82, 153.3 -67.94, -20.06 -72.25, 117.15 186.14, 67.99 74.54, 10.49 in-na in 9.5489 Saltbr-na 6.9967 HRD-in -62.69, -52.02 73.18, 5.96 na-out-out SNCaoo out-out ActLoopNT-out 4.4905 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nnoi APE10-dihe-na 999.0, 97.54 APE9-dihe-na 147.57, 178.93 APE8-dihe-in -82.42, 99.29 APE8-rot-na 182.98 APE67-dihe-in -61.62, -27.64 -30.09, -49.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.3161 APE9-dist-in 5.4213 C202S None None XRAY 1.3 0.129 0.167 A 323.0 303.0 11 27 16 11 [[120, 380]] 1.0 5y90 STE_MAP2K7_HUMAN STE 6e-81 277.5 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 5B2LA O14733 104 403 419.0 No_ligand No_ligand Inactive DFGout 14.2205 12.7571 None -76.46, 153.91 -65.2, -15.13 -85.09, 122.54 173.15, 100.21 62.68, 24.87 in-na in 9.4194 Saltbr-na 5.6698 HRD-in -68.9, -49.38 74.06, -2.7 na-out-none SNCaon out-none ActLoopNT-out 4.2004 ActLoopCT-none nonTYR APEdihe_aaiai APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -162.08 APE8-dihe-in -44.37, 121.12 APE8-rot-na 186.74 APE67-dihe-in -64.38, -28.47 -52.0, -32.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.6403 C202S None None XRAY 2.1 0.196 0.264 A 324.0 288.0 12 27 15 12 [[120, 380]] 1.0 5b2l STE_MAP2K7_HUMAN STE 6.1e-81 277.5 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 6YFZA O14733 100 405 419.0 No_ligand No_ligand Inactive DFGout 14.5775 12.2222 None -65.69, 154.5 -79.31, -18.38 -69.44, 109.63 184.59, 79.86 78.77, 13.16 in-na in 9.3987 Saltbr-na 6.3451 HRD-in -62.74, -49.8 76.32, 4.02 na-out-out SNCaoo out-out ActLoopNT-out 4.4948 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -77.79 APE8-dihe-out -84.51, 16.67 APE8-rot-na 53.16 APE67-dihe-in -41.58, -34.26 -52.26, -31.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2857 None None None XRAY 1.9 0.194 0.237 A 307.0 295.0 11 27 16 11 [[120, 380]] 1.0 6yfz STE_MAP2K7_HUMAN STE 2.4e-80 275.5 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 6QFRA O14733 102 402 419.0 No_ligand No_ligand Inactive DFGout 14.5966 12.3839 None -68.75, 152.88 -81.33, -15.77 -67.92, 119.36 183.03, 83.76 68.04, 20.01 in-na in 9.4705 Saltbr-na 999.0 HRD-in -65.0, -46.28 62.7, 21.32 na-out-none SNCaon out-none ActLoopNT-out 3.859 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -37.89 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.226 0.258 A 318.0 269.0 32 27 12 15 [[120, 380]] 1.0 6qfr STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 5B2KA O14733 104 400 419.0 No_ligand No_ligand Inactive DFGout 14.1779 12.826 None -145.83, -155.93 -124.85, 167.56 76.21, 128.09 210.31, 153.65 -109.7, 999.0 out-na out 15.7307 Saltbr-na 12.8485 HRD-in -54.56, -36.85 65.93, -59.05 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 130.04 APE8-dihe-out 55.4, 38.34 APE8-rot-na 203.13 APE67-dihe-in -68.4, -36.69 -133.56, -66.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7832 None None None XRAY 2.75 0.273 0.328 A 324.0 264.0 33 27 12 15 [[120, 380]] 1.0 5b2k STE_MAP2K7_HUMAN STE 2.9e-80 275.3 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 6YG0A O14733 102 402 419.0 No_ligand No_ligand Inactive DFGout 14.4436 11.9396 None -72.91, 151.34 -70.02, -17.53 -75.75, 118.68 182.61, 94.7 60.63, 28.05 in-na in 9.3051 Saltbr-na 5.0235 HRD-in -74.48, -46.31 69.89, 17.18 na-out-none SNCaon out-none ActLoopNT-out 3.955 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -103.82, -14.41 999.0, -62.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S271D,T275D None None XRAY 2.0 0.197 0.245 A 307.0 280.0 21 27 13 14 [[120, 380]] 1.0 6yg0 STE_MAP2K7_HUMAN STE 3.3e-80 275.1 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 7CBXA O14733 103 402 419.0 FU6:60501 Type1 Inactive DFGout 14.7179 13.1222 None -67.93, 157.76 -80.71, -13.18 -68.95, 114.38 181.8, 83.48 65.7, 23.26 in-na in 9.5783 Saltbr-na 5.4486 HRD-in -62.0, -47.36 71.71, 5.73 na-out-none SNCaon out-none ActLoopNT-out 4.5008 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 169.9 APE8-rot-na 54.6 APE67-dihe-in -52.38, -32.21 -121.54, 13.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C202S None None XRAY 2.061 0.184 0.224 A 323.0 281.0 19 27 15 12 [[120, 380]] 1.0 7cbx STE_MAP2K7_HUMAN STE 6e-81 277.5 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 5Z1EA O14733 103 419 419.0 95U:60501 Type1 Inactive DFGout 14.5039 12.6055 None -85.05, 151.13 -68.45, -19.93 -71.62, 116.06 181.31, 86.38 78.35, 8.74 in-na in 9.4863 Saltbr-na 6.0011 HRD-in -59.34, -43.5 68.0, 9.1 na-out-none SNCaon out-none ActLoopNT-out 4.5474 ActLoopCT-none nonTYR APEdihe_aaiai APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -160.98 APE8-dihe-in -89.81, 122.82 APE8-rot-na 181.7 APE67-dihe-in -53.89, -34.76 -49.14, -44.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.0891 None None None XRAY 2.3 0.199 0.283 A 324.0 295.0 21 27 15 12 [[120, 380]] 1.0 5z1e STE_MAP2K7_HUMAN STE 6.1e-81 277.5 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 6YG4A O14733 103 401 419.0 SU9:60507 Type1 Inactive DFGout 14.5511 12.8869 None -62.29, 150.09 -89.79, 2.79 -75.42, 126.27 178.68, 55.69 68.55, 22.06 in-na in 9.1836 Saltbr-na 5.4846 HRD-out -61.32, 126.06 -67.57, -75.86 na-out-none SNCaon out-none ActLoopNT-out 4.7457 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None CSD202,CSO260 XRAY 2.3 0.213 0.255 A 307.0 260.0 39 27 6 21 [[120, 380]] 1.0 6yg4 STE_MAP2K7_HUMAN STE 2.4e-80 275.5 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 6YG5A O14733 101 403 419.0 IHH:60501 Type1 Inactive DFGout 14.6243 12.5001 None -82.13, 150.25 -82.61, 0.2 -71.2, 148.66 192.27, 49.92 16.39, 43.73 in-na in 9.0934 Saltbr-na 999.0 HRD-in -91.88, -54.83 65.15, 26.24 na-out-none SNCaon out-none ActLoopNT-out 3.7145 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None CSO202,CSO260 XRAY 2.4 0.233 0.281 A 307.0 262.0 41 27 6 21 [[120, 380]] 1.0 6yg5 STE_MAP2K7_HUMAN STE 2.4e-80 275.5 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 3WZUA O14733 104 402 419.0 1FM:60600 Type1 Inactive DFGout 11.7992 6.6541 None -93.22, 113.48 -84.76, 103.03 -136.57, -104.81 215.37, 93.4 104.1, 999.0 none-na none 999.0 Saltbr-na 999.0 HRD-out -25.62, 111.55 -64.83, -46.46 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_nnno APE10-dihe-na 999.0, -69.55 APE9-dihe-na -125.65, -59.15 APE8-dihe-out -72.37, 11.48 APE8-rot-na 285.95 APE67-dihe-in -63.78, -33.54 -102.86, -19.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.3239 None None None XRAY 3.01 0.24 0.322 A 324.0 270.0 29 27 13 14 [[120, 380]] 1.0 3wzu STE_MAP2K7_HUMAN STE 2.9e-80 275.3 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 6YG6A O14733 103 403 419.0 OQ8:60502 Type2 Inactive DFGout 16.1841 8.3099 None -139.95, -178.26 -130.53, 97.33 -80.93, -18.66 197.5, 70.15 99.84, 999.0 out-na out 11.8197 Saltbr-na 9.0572 HRD-in -74.08, -54.03 80.87, -1.6 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_nnno APE10-dihe-na 999.0, 156.96 APE9-dihe-na -153.68, 151.67 APE8-dihe-in -133.13, 149.82 APE8-rot-na 44.78 APE67-dihe-out -157.98, 122.58 -86.76, 138.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 20.3416 S271D,T275D None None XRAY 2.15 0.205 0.239 A 307.0 284.0 17 27 13 14 [[120, 380]] 1.0 6yg6 STE_MAP2K7_HUMAN STE 3.3e-80 275.1 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 6YG6B O14733 104 403 419.0 OQ8:60504 Type2 Inactive DFGout 16.2787 8.6873 None -139.8, 179.92 -130.12, 95.85 -78.51, -14.19 197.24, 65.37 105.19, 999.0 out-na out 11.2208 Saltbr-na 7.8821 HRD-in -78.17, -53.67 81.94, -0.01 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 171.84 APE8-dihe-in -146.43, 151.13 APE8-rot-na 48.74 APE67-dihe-out -158.28, 125.4 -86.76, 140.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 20.4249 S271D,T275D None None XRAY 2.15 0.205 0.239 B 307.0 281.0 19 27 12 15 [[120, 380]] 1.0 6yg6 STE_MAP2K7_HUMAN STE 3.3e-80 275.1 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 6YG2A O14733 102 404 419.0 1E8:60513,8E8:60514 Allosteric,Type1.5_Front Inactive None 999.0 999.0 None -141.51, 164.72 -158.89, -8.67 -87.07, 69.85 999.0, 999.0 141.69, -6.89 in-na in 9.9753 Saltbr-na 8.41 HRD-in -58.05, -52.64 72.65, 3.0 na-out-none SNCaon out-none ActLoopNT-out 4.4332 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 29.92 APE8-rot-na 285.9 APE67-dihe-in -48.65, -40.74 -57.35, -36.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.181 0.23 A 307.0 290.0 13 27 14 13 [[120, 380]] 1.0 6yg2 STE_MAP2K7_HUMAN STE 2.4e-80 275.5 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 2DYLA O14733 103 402 419.0 No_ligand No_ligand None DFGin 5.4945 14.595 BLAminus -110.0, 167.28 -3.39, 131.78 -126.62, 56.73 342.81, 59.02 -75.18, 24.89 in-na in 8.8064 Saltbr-na 3.4564 HRD-in -38.91, -44.57 67.82, 6.27 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -170.9 APE8-rot-na 261.07 APE67-dihe-in -82.69, -17.86 -87.14, -15.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S271D,T275D None None XRAY 2.45 0.217 0.283 A 318.0 272.0 28 27 13 14 [[120, 380]] 1.0 2dyl STE_MAP2K7_HUMAN STE 3.7e-80 274.9 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 5Z1DA O14733 103 403 419.0 95U:60501 Type1 None DFGin 5.8572 14.5846 BLAminus -132.64, 165.55 65.51, 87.28 -111.34, 26.51 319.06, 84.39 -58.48, -30.36 in-na in 8.3569 Saltbr-na 4.0434 HRD-in -83.1, -42.1 68.08, 4.78 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiai APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 121.65 APE8-dihe-in -8.48, 107.0 APE8-rot-na 193.18 APE67-dihe-in -53.9, -37.87 -45.41, -42.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.9979 None None None XRAY 2.28 0.195 0.258 A 324.0 274.0 27 27 14 13 [[120, 380]] 1.0 5z1d STE_MAP2K7_HUMAN STE 9.7e-80 273.6 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 6YG3A O14733 103 400 419.0 6HF:60510 Type1 None DFGin 6.1952 14.5493 BLAminus -146.55, 178.23 54.3, 83.97 -103.73, 30.03 316.89, 91.95 -57.17, -29.89 in-na in 8.3452 Saltbr-na 3.3604 HRD-in -81.36, -52.29 76.4, 12.98 na-in-none SNCain in-none ActLoopNT-in 2.9822 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.05 0.191 0.235 A 307.0 265.0 33 27 8 19 [[120, 380]] 1.0 6yg3 STE_MAP2K7_HUMAN STE 2.4e-80 275.5 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7

STE_MAP2K7 (Dual specificity mitogen-activated protein kinase kinase 7)

Total number of chains: 42
Active chains: 5
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 15 35.7% 5Y90A
DFGin BLAminus 10 23.8% AF-O14733-K1A
DFGin None 7 16.7% 7OVNA
DFGin ABAminus 5 11.9% 6QFLA
DFGout BBAminus 2 4.8% 6YG7B
DFGin BLAplus 1 2.4% 7OVIA
DFGin BLBplus 1 2.4% 7OVJA
None None 1 2.4% 6YG2A

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP2K7 MP2K7_HUMAN AF-O14733-K1A O14733 112 388 419.0 No_ligand No_ligand Active DFGin 6.1518 12.8912 BLAminus -144.89, 179.02 60.87, 74.04 -92.3, 11.23 308.58, 103.72 -61.88, -23.93 in-na in 7.6157 Saltbr-na 2.6548 HRD-in -80.04, -46.28 68.18, 5.82 na-in-in SNCaii in-in ActLoopNT-in 2.8994 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -141.79, 153.26 APE9-dihe-na 72.6, 179.68 APE8-dihe-in -81.41, 127.53 APE8-rot-na 184.94 APE67-dihe-in -59.35, -26.49 -52.46, -39.21 APE12-dist-in 12.2883 APE11-dist-in 9.8685 APE10-dist-in 5.4411 APE9-dist-in 3.3372 None None None AF2 -1.0 1.0 1.0 A 277.0 277.0 0 27 27 0 [[120, 380]] 1.0 AF-O14733-K1 Homo sapiens STE_MAP2K7_HUMAN STE 1.6e-80 276.1 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN AF-O14733-K3A O14733 112 388 419.0 No_ligand No_ligand Active DFGin 6.039 12.9631 BLAminus -142.81, 179.24 63.68, 76.23 -95.26, 8.18 307.0, 99.42 -58.85, -29.95 in-na in 7.7118 Saltbr-na 2.6849 HRD-in -74.82, -48.5 72.99, -4.88 na-in-in SNCaii in-in ActLoopNT-in 2.8916 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -119.76, 112.73 APE9-dihe-na 151.27, 162.54 APE8-dihe-in -75.49, 123.1 APE8-rot-na 183.03 APE67-dihe-in -55.59, -26.31 -51.09, -39.22 APE12-dist-in 12.3269 APE11-dist-in 10.2555 APE10-dist-in 4.9499 APE9-dist-in 4.1313 None None None AF2 -1.0 1.0 1.0 A 277.0 277.0 0 27 27 0 [[120, 380]] 1.0 AF-O14733-K3 Homo sapiens STE_MAP2K7_HUMAN STE 1.6e-80 276.1 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 6YG1A O14733 86 404 419.0 No_ligand No_ligand Active DFGin 5.9305 14.6445 BLAminus -139.75, -178.51 55.48, 92.06 -111.01, 29.63 315.16, 93.19 -69.74, -26.75 in-na in 8.1105 Saltbr-na 3.0077 HRD-in -72.55, -50.64 76.96, 6.43 na-in-in SNCaii in-in ActLoopNT-in 2.9082 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -79.26, 103.62 APE9-dihe-na 136.94, 169.34 APE8-dihe-in -92.63, 126.44 APE8-rot-na 170.6 APE67-dihe-in -62.5, -26.78 -51.81, -44.28 APE12-dist-in 12.7902 APE11-dist-in 9.924 APE10-dist-in 5.3977 APE9-dist-in 3.4564 S271D,T275D None None XRAY 2.22 0.205 0.232 A 348.0 314.0 5 27 27 0 [[120, 380]] 1.0 6yg1 Homo sapiens STE_MAP2K7_HUMAN STE 5.1e-80 274.6 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 6YG1B O14733 93 404 419.0 No_ligand No_ligand Active DFGin 5.8891 14.977 BLAminus -142.37, -179.59 56.42, 90.83 -110.86, 29.11 314.92, 97.64 -68.6, -26.26 in-na in 8.8917 Saltbr-na 4.9518 HRD-in -68.85, -52.56 75.41, 8.03 na-in-in SNCaii in-in ActLoopNT-in 2.9323 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -77.32, 102.16 APE9-dihe-na 141.15, 166.92 APE8-dihe-in -91.69, 124.38 APE8-rot-na 170.36 APE67-dihe-in -60.55, -28.59 -53.55, -45.43 APE12-dist-in 12.7222 APE11-dist-in 9.7884 APE10-dist-in 5.3121 APE9-dist-in 3.4756 S271D,T275D None None XRAY 2.22 0.205 0.232 B 348.0 307.0 5 27 27 0 [[120, 380]] 1.0 6yg1 Homo sapiens STE_MAP2K7_HUMAN STE 5.1e-80 274.6 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 6YG1C O14733 86 405 419.0 No_ligand No_ligand Active DFGin 5.867 14.8801 BLAminus -143.88, 179.51 55.81, 91.73 -110.17, 29.88 314.81, 97.84 -67.15, -27.41 in-na in 8.669 Saltbr-na 3.7601 HRD-in -70.3, -52.02 75.96, 8.08 na-in-in SNCaii in-in ActLoopNT-in 2.9308 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -78.45, 102.93 APE9-dihe-na 140.93, 165.22 APE8-dihe-in -88.99, 125.59 APE8-rot-na 170.38 APE67-dihe-in -58.75, -28.89 -54.03, -43.27 APE12-dist-in 12.6582 APE11-dist-in 9.8249 APE10-dist-in 5.3379 APE9-dist-in 3.4565 S271D,T275D None None XRAY 2.22 0.205 0.232 C 348.0 315.0 5 27 27 0 [[120, 380]] 1.0 6yg1 Homo sapiens STE_MAP2K7_HUMAN STE 5.1e-80 274.6 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 6QFLA O14733 102 402 419.0 No_ligand No_ligand Inactive DFGin 6.1869 15.5229 ABAminus -126.91, -56.87 -92.09, 122.12 -125.66, 36.65 313.06, 96.64 -68.73, -31.95 in-na in 9.0244 Saltbr-na 3.5267 HRD-in -77.84, -48.81 72.51, 6.74 na-in-out SNCaio in-out ActLoopNT-in 2.9872 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nnoi APE10-dihe-na 999.0, 153.08 APE9-dihe-na -74.6, -175.14 APE8-dihe-in -65.82, 132.42 APE8-rot-na 184.94 APE67-dihe-in -67.15, -27.95 -62.93, -24.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.0888 APE9-dist-in 3.62 None None None XRAY 2.2 0.217 0.247 A 318.0 287.0 14 27 18 9 [[120, 380]] 1.0 6qfl Homo sapiens STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 6QFTA O14733 102 400 419.0 J0B:60501 Type1 Inactive DFGin 6.0919 14.6665 ABAminus -132.5, -47.39 -100.07, 114.73 -122.28, 26.64 317.67, 98.18 -69.72, -23.3 in-na in 8.4328 Saltbr-na 3.1711 HRD-in -71.0, -47.5 68.26, 12.64 na-in-none SNCain in-none ActLoopNT-in 2.8177 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -79.93 APE8-rot-na 305.39 APE67-dihe-in -84.39, -17.02 -72.51, -17.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.24 0.287 A 318.0 276.0 22 27 15 12 [[120, 380]] 1.0 6qft Homo sapiens STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 6QG4A O14733 111 401 419.0 J0E:60501 Type1 Inactive DFGin 6.1822 15.1809 ABAminus -117.76, -64.0 -82.44, 121.85 -124.1, 34.74 316.86, 109.91 -70.66, -23.17 in-na in 8.8168 Saltbr-na 4.4158 HRD-in -81.15, -52.15 67.31, 24.06 na-in-none SNCain in-none ActLoopNT-in 3.0048 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -96.03, 10.82 999.0, 49.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.236 0.269 A 318.0 264.0 27 27 14 13 [[120, 380]] 1.0 6qg4 Homo sapiens STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 6QG7A O14733 102 401 419.0 6HL:60501 Type1 Inactive DFGin 5.9114 15.2319 ABAminus -123.01, -51.98 -107.12, 111.08 -111.71, 38.94 316.9, 98.78 -70.4, -27.38 in-na in 8.9966 Saltbr-na 5.5763 HRD-in -77.58, -50.11 69.18, 12.05 na-in-out SNCaio in-out ActLoopNT-in 2.9311 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nnoi APE10-dihe-na 999.0, 133.85 APE9-dihe-na -74.73, -170.49 APE8-dihe-in -66.48, 132.0 APE8-rot-na 174.14 APE67-dihe-in -67.76, -29.49 -64.52, -21.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.8645 APE9-dist-in 3.5369 None None None XRAY 2.1 0.236 0.268 A 318.0 282.0 18 27 18 9 [[120, 380]] 1.0 6qg7 Homo sapiens STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 6QHOA O14733 111 401 419.0 J3H:60501 Type1 Inactive DFGin 6.151 14.841 ABAminus -134.48, -24.2 -123.38, 105.65 -115.94, 26.77 316.11, 97.72 -69.46, -18.96 in-na in 8.6446 Saltbr-na 2.9685 HRD-in -77.76, -54.43 71.88, 11.21 na-in-none SNCain in-none ActLoopNT-in 3.4399 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.226 0.281 A 318.0 266.0 25 27 12 15 [[120, 380]] 1.0 6qho Homo sapiens STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 6IB0A O14733 101 400 419.0 H8Z:60501 Type1 Inactive DFGin 6.0991 14.9841 BLAminus -148.24, 171.72 65.71, 75.57 -92.89, 38.74 314.28, 84.61 -68.11, -29.03 in-na in 8.7408 Saltbr-na 4.0034 HRD-in -70.72, -53.16 74.59, 10.21 na-in-out SNCaio in-out ActLoopNT-in 3.2572 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nnoi APE10-dihe-na 999.0, 128.1 APE9-dihe-na -73.49, -154.36 APE8-dihe-in -71.53, 139.51 APE8-rot-na 175.13 APE67-dihe-in -66.31, -29.13 -74.24, -29.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.946 APE9-dist-in 3.7346 None None None XRAY 2.6 0.23 0.271 A 318.0 290.0 10 27 17 10 [[120, 380]] 1.0 6ib0 Homo sapiens STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 6QHRA O14733 111 401 419.0 J3N:60501 Type1 Inactive DFGin 6.0896 15.3278 BLAminus -146.67, 176.67 62.9, 89.87 -111.41, 30.09 309.69, 89.26 -65.92, -26.31 in-na in 8.7379 Saltbr-na 3.5821 HRD-in -74.13, -47.12 71.22, 3.25 na-in-out SNCaio in-out ActLoopNT-in 2.897 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nnoi APE10-dihe-na 999.0, 133.41 APE9-dihe-na -75.58, -168.78 APE8-dihe-in -70.75, 132.36 APE8-rot-na 181.96 APE67-dihe-in -70.59, -23.34 -59.05, -27.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.9951 APE9-dist-in 3.8609 None None None XRAY 2.52 0.241 0.294 A 318.0 276.0 15 27 18 9 [[120, 380]] 1.0 6qhr Homo sapiens STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 7OVIA O14733 102 402 419.0 2GI:60501 Type1.5_Front Inactive DFGin 4.7552 13.5989 BLAplus -140.91, 171.28 50.96, 52.63 -104.5, 0.42 42.65, 71.15 -92.35, -151.25 in-na in 9.7926 Saltbr-na 8.3457 HRD-out -95.23, 128.06 -114.34, -2.31 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.95 0.211 0.25 A 318.0 262.0 39 27 4 23 [[120, 380]] 1.0 7ovi Homo sapiens STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 7OVJA O14733 102 403 419.0 24N:60501 Type1.5_Front Inactive DFGin 5.2382 14.0399 BLBplus -149.66, 173.75 53.03, 68.8 -120.16, 126.9 30.41, 81.15 125.32, 999.0 in-na in 9.4969 Saltbr-na 8.4026 HRD-in -63.57, -57.01 68.81, 21.85 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiai APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 162.2 APE8-dihe-in -71.05, 126.52 APE8-rot-na 187.98 APE67-dihe-in -67.38, -26.76 -67.11, -24.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.1906 None None None XRAY 2.35 0.204 0.244 A 318.0 276.0 26 27 12 15 [[120, 380]] 1.0 7ovj Homo sapiens STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 5B2MA O14733 105 400 419.0 No_ligand No_ligand Inactive DFGin 9.579 19.7731 None -127.86, 134.8 -161.61, -89.86 49.84, 999.0 177.0, 80.04 999.0, 999.0 out-na out 12.7097 Saltbr-na 12.8043 HRD-in -62.81, -53.51 71.04, 8.99 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_nnno APE10-dihe-na 999.0, 42.27 APE9-dihe-na -108.06, 130.67 APE8-dihe-out -63.3, -33.92 APE8-rot-na 122.97 APE67-dihe-in -63.12, -24.65 -98.4, 12.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.8922 None None None XRAY 3.06 0.291 0.364 A 324.0 255.0 41 27 12 15 [[120, 380]] 1.0 5b2m Homo sapiens STE_MAP2K7_HUMAN STE 2.9e-80 275.3 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 7OVLA O14733 102 402 419.0 1XZ:60501 Type1 Inactive DFGin 4.9356 14.7119 None -131.83, 135.57 1.69, 124.27 -119.89, 81.31 23.68, 77.2 -67.86, -14.37 in-na in 9.3478 Saltbr-na 999.0 HRD-in -75.58, -48.66 66.23, 10.91 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nnoi APE10-dihe-na 999.0, 161.45 APE9-dihe-na -75.62, -169.03 APE8-dihe-in -66.96, 129.78 APE8-rot-na 196.63 APE67-dihe-in -77.35, -36.68 -69.13, -18.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.6445 APE9-dist-in 3.4276 None None None XRAY 2.9 0.248 0.27 A 318.0 279.0 22 27 15 12 [[120, 380]] 1.0 7ovl Homo sapiens STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 7OVMA O14733 102 402 419.0 21I:60501 Type1 Inactive DFGin 5.5693 14.8886 None -100.36, -115.13 -133.81, 137.4 -113.6, 82.88 349.67, 74.13 -90.73, -9.2 in-na in 9.611 Saltbr-na 4.2453 HRD-in -65.68, -55.04 65.08, 15.11 na-in-none SNCain in-none ActLoopNT-in 2.9245 ActLoopCT-none nonTYR APEdihe_aaiai APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 173.58 APE8-dihe-in -69.89, 133.33 APE8-rot-na 191.29 APE67-dihe-in -78.39, -27.08 -69.91, -12.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.3277 None None None XRAY 2.9 0.233 0.286 A 318.0 282.0 19 27 16 11 [[120, 380]] 1.0 7ovm Homo sapiens STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 7OVNA O14733 102 402 419.0 2I8:60501 Type1 Inactive DFGin 4.9662 14.684 None -79.07, -108.85 -132.92, 129.36 -118.94, 86.57 14.8, 59.14 -92.78, -9.46 in-na in 8.7495 Saltbr-na 3.314 HRD-in -73.42, -49.75 66.93, 12.16 na-in-out SNCaio in-out ActLoopNT-in 2.7697 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nnoi APE10-dihe-na 999.0, 179.48 APE9-dihe-na -73.36, -177.84 APE8-dihe-in -62.31, 134.27 APE8-rot-na 205.08 APE67-dihe-in -72.39, -30.0 -65.21, -22.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.6301 APE9-dist-in 3.5925 None None None XRAY 2.9 0.225 0.257 A 318.0 283.0 18 27 17 10 [[120, 380]] 1.0 7ovn Homo sapiens STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 9HZ0A O14733 101 401 419.0 A1IY7:60501 Type1 Inactive DFGin 5.7468 14.9744 None -112.81, -166.53 -54.75, 142.97 -115.5, 75.64 327.47, 81.17 -69.37, -28.6 in-na in 8.8354 Saltbr-na 999.0 HRD-in -68.14, -48.97 74.35, -1.92 na-in-none SNCain in-none ActLoopNT-in 2.9492 ActLoopCT-none nonTYR APEdihe_aaiai APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 140.19 APE8-dihe-in -74.03, 132.92 APE8-rot-na 185.24 APE67-dihe-in -65.54, -21.82 -64.33, -35.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.7967 None None None XRAY 2.25 0.223 0.263 A 318.0 278.0 23 27 15 12 [[120, 380]] 1.0 9hz0 Homo sapiens STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 7OVKA O14733 102 401 419.0 2I5:60502 Type1.5_Back Inactive DFGin 5.7986 14.1308 None -146.4, 162.27 58.41, 85.98 -92.37, 999.0 319.32, 113.16 999.0, 999.0 in-na in 9.452 Saltbr-na 7.5825 HRD-in -63.92, -73.21 74.68, -0.77 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.05 0.217 0.244 A 318.0 256.0 44 27 2 25 [[120, 380]] 1.0 7ovk Homo sapiens STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 6IB2A O14733 102 401 419.0 862:60501 Type1.5_Front Inactive DFGin 5.2764 14.0728 None -91.61, -76.02 -109.31, 164.08 -125.38, 999.0 315.5, 111.59 999.0, 999.0 in-na in 9.9266 Saltbr-na 8.3493 HRD-out -68.06, 100.79 -82.59, 24.57 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -28.73 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.224 0.25 A 318.0 265.0 35 27 8 19 [[120, 380]] 1.0 6ib2 Homo sapiens STE_MAP2K7_HUMAN STE 3.1e-80 275.2 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 6YG7A O14733 102 403 419.0 OQ2:60504 Type2 Inactive DFGout 14.3068 9.3634 BBAminus -135.79, -174.49 -146.78, 99.14 -72.95, -12.7 271.17, 101.44 54.78, 27.39 out-na out 11.4547 Saltbr-na 10.3686 HRD-in -83.32, -61.5 88.57, -4.6 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanao APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 164.72 APE8-rot-na 77.42 APE67-dihe-out -154.57, 128.74 -105.88, 129.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S271D,T275D None None XRAY 2.2 0.209 0.251 A 307.0 278.0 24 27 12 15 [[120, 380]] 1.0 6yg7 Homo sapiens STE_MAP2K7_HUMAN STE 3.3e-80 275.1 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 6YG7B O14733 103 403 419.0 OQ2:60501 Type2 Inactive DFGout 14.2314 9.1215 BBAminus -134.34, -173.96 -146.89, 101.17 -73.22, -11.42 272.26, 99.4 58.67, 31.18 out-na out 11.6145 Saltbr-na 10.5414 HRD-in -80.67, -58.84 84.82, -5.07 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 165.49 APE8-dihe-in -163.35, 172.69 APE8-rot-na 73.01 APE67-dihe-out -154.98, 128.01 -103.81, 131.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 20.3622 S271D,T275D None None XRAY 2.2 0.209 0.251 B 307.0 280.0 21 27 14 13 [[120, 380]] 1.0 6yg7 Homo sapiens STE_MAP2K7_HUMAN STE 3.3e-80 275.1 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 6YZ4A O14733 101 404 419.0 1E8:60514 Allosteric Inactive DFGout 14.5151 13.0633 None -65.33, 150.4 -71.99, -22.54 -69.32, 117.0 179.71, 79.57 76.56, 9.7 in-na in 9.9774 Saltbr-na 5.7683 HRD-in -58.98, -51.27 69.96, 9.38 na-out-out SNCaoo out-out ActLoopNT-out 4.641 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 162.56 APE8-dihe-out -103.96, 46.58 APE8-rot-na 270.86 APE67-dihe-in -43.13, -49.42 -40.36, -39.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.5545 None None None XRAY 1.7 0.171 0.206 A 307.0 290.0 14 27 17 10 [[120, 380]] 1.0 6yz4 Homo sapiens STE_MAP2K7_HUMAN STE 2.4e-80 275.5 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 5Y8UA O14733 103 402 419.0 No_ligand No_ligand Inactive DFGout 13.212 8.7971 None -105.43, 104.01 -75.1, 93.5 -77.42, 118.96 218.18, 57.42 -77.04, 145.42 out-na out 16.1698 Saltbr-na 15.7899 HRD-in -66.06, -43.39 62.31, 29.58 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_nnoo APE10-dihe-na 999.0, 107.71 APE9-dihe-na -104.74, 41.32 APE8-dihe-in -82.15, 94.45 APE8-rot-na 354.74 APE67-dihe-out -98.49, 44.79 63.11, 64.93 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 23.4742 APE9-dist-out 15.5681 C260S None None XRAY 2.92 0.234 0.299 A 323.0 267.0 33 27 14 13 [[120, 380]] 1.0 5y8u Homo sapiens STE_MAP2K7_HUMAN STE 9.6e-80 273.6 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 5Y90A O14733 103 419 419.0 No_ligand No_ligand Inactive DFGout 14.4779 12.3818 None -68.82, 153.3 -67.94, -20.06 -72.25, 117.15 186.14, 67.99 74.54, 10.49 in-na in 9.5489 Saltbr-na 6.9967 HRD-in -62.69, -52.02 73.18, 5.96 na-out-out SNCaoo out-out ActLoopNT-out 4.4905 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nnoi APE10-dihe-na 999.0, 97.54 APE9-dihe-na 147.57, 178.93 APE8-dihe-in -82.42, 99.29 APE8-rot-na 182.98 APE67-dihe-in -61.62, -27.64 -30.09, -49.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.3161 APE9-dist-in 5.4213 C202S None None XRAY 1.3 0.129 0.167 A 323.0 303.0 11 27 16 11 [[120, 380]] 1.0 5y90 Homo sapiens STE_MAP2K7_HUMAN STE 6e-81 277.5 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 5B2LA O14733 104 403 419.0 No_ligand No_ligand Inactive DFGout 14.2205 12.7571 None -76.46, 153.91 -65.2, -15.13 -85.09, 122.54 173.15, 100.21 62.68, 24.87 in-na in 9.4194 Saltbr-na 5.6698 HRD-in -68.9, -49.38 74.06, -2.7 na-out-none SNCaon out-none ActLoopNT-out 4.2004 ActLoopCT-none nonTYR APEdihe_aaiai APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -162.08 APE8-dihe-in -44.37, 121.12 APE8-rot-na 186.74 APE67-dihe-in -64.38, -28.47 -52.0, -32.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.6403 C202S None None XRAY 2.1 0.196 0.264 A 324.0 288.0 12 27 15 12 [[120, 380]] 1.0 5b2l Homo sapiens STE_MAP2K7_HUMAN STE 6.1e-81 277.5 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 6YFZA O14733 100 405 419.0 No_ligand No_ligand Inactive DFGout 14.5775 12.2222 None -65.69, 154.5 -79.31, -18.38 -69.44, 109.63 184.59, 79.86 78.77, 13.16 in-na in 9.3987 Saltbr-na 6.3451 HRD-in -62.74, -49.8 76.32, 4.02 na-out-out SNCaoo out-out ActLoopNT-out 4.4948 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -77.79 APE8-dihe-out -84.51, 16.67 APE8-rot-na 53.16 APE67-dihe-in -41.58, -34.26 -52.26, -31.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2857 None None None XRAY 1.9 0.194 0.237 A 307.0 295.0 11 27 16 11 [[120, 380]] 1.0 6yfz Homo sapiens STE_MAP2K7_HUMAN STE 2.4e-80 275.5 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 6QFRA O14733 102 402 419.0 No_ligand No_ligand Inactive DFGout 14.5966 12.3839 None -68.75, 152.88 -81.33, -15.77 -67.92, 119.36 183.03, 83.76 68.04, 20.01 in-na in 9.4705 Saltbr-na 999.0 HRD-in -65.0, -46.28 62.7, 21.32 na-out-none SNCaon out-none ActLoopNT-out 3.859 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -37.89 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.226 0.258 A 318.0 269.0 32 27 12 15 [[120, 380]] 1.0 6qfr Homo sapiens STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 5B2KA O14733 104 400 419.0 No_ligand No_ligand Inactive DFGout 14.1779 12.826 None -145.83, -155.93 -124.85, 167.56 76.21, 128.09 210.31, 153.65 -109.7, 999.0 out-na out 15.7307 Saltbr-na 12.8485 HRD-in -54.56, -36.85 65.93, -59.05 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 130.04 APE8-dihe-out 55.4, 38.34 APE8-rot-na 203.13 APE67-dihe-in -68.4, -36.69 -133.56, -66.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7832 None None None XRAY 2.75 0.273 0.328 A 324.0 264.0 33 27 12 15 [[120, 380]] 1.0 5b2k Homo sapiens STE_MAP2K7_HUMAN STE 2.9e-80 275.3 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 6YG0A O14733 102 402 419.0 No_ligand No_ligand Inactive DFGout 14.4436 11.9396 None -72.91, 151.34 -70.02, -17.53 -75.75, 118.68 182.61, 94.7 60.63, 28.05 in-na in 9.3051 Saltbr-na 5.0235 HRD-in -74.48, -46.31 69.89, 17.18 na-out-none SNCaon out-none ActLoopNT-out 3.955 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -103.82, -14.41 999.0, -62.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S271D,T275D None None XRAY 2.0 0.197 0.245 A 307.0 280.0 21 27 13 14 [[120, 380]] 1.0 6yg0 Homo sapiens STE_MAP2K7_HUMAN STE 3.3e-80 275.1 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 7CBXA O14733 103 402 419.0 FU6:60501 Type1 Inactive DFGout 14.7179 13.1222 None -67.93, 157.76 -80.71, -13.18 -68.95, 114.38 181.8, 83.48 65.7, 23.26 in-na in 9.5783 Saltbr-na 5.4486 HRD-in -62.0, -47.36 71.71, 5.73 na-out-none SNCaon out-none ActLoopNT-out 4.5008 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 169.9 APE8-rot-na 54.6 APE67-dihe-in -52.38, -32.21 -121.54, 13.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C202S None None XRAY 2.061 0.184 0.224 A 323.0 281.0 19 27 15 12 [[120, 380]] 1.0 7cbx Homo sapiens STE_MAP2K7_HUMAN STE 6e-81 277.5 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 5Z1EA O14733 103 419 419.0 95U:60501 Type1 Inactive DFGout 14.5039 12.6055 None -85.05, 151.13 -68.45, -19.93 -71.62, 116.06 181.31, 86.38 78.35, 8.74 in-na in 9.4863 Saltbr-na 6.0011 HRD-in -59.34, -43.5 68.0, 9.1 na-out-none SNCaon out-none ActLoopNT-out 4.5474 ActLoopCT-none nonTYR APEdihe_aaiai APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -160.98 APE8-dihe-in -89.81, 122.82 APE8-rot-na 181.7 APE67-dihe-in -53.89, -34.76 -49.14, -44.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.0891 None None None XRAY 2.3 0.199 0.283 A 324.0 295.0 21 27 15 12 [[120, 380]] 1.0 5z1e Homo sapiens STE_MAP2K7_HUMAN STE 6.1e-81 277.5 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 6YG4A O14733 103 401 419.0 SU9:60507 Type1 Inactive DFGout 14.5511 12.8869 None -62.29, 150.09 -89.79, 2.79 -75.42, 126.27 178.68, 55.69 68.55, 22.06 in-na in 9.1836 Saltbr-na 5.4846 HRD-out -61.32, 126.06 -67.57, -75.86 na-out-none SNCaon out-none ActLoopNT-out 4.7457 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None CSD202,CSO260 XRAY 2.3 0.213 0.255 A 307.0 260.0 39 27 6 21 [[120, 380]] 1.0 6yg4 Homo sapiens STE_MAP2K7_HUMAN STE 2.4e-80 275.5 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 6YG5A O14733 101 403 419.0 IHH:60501 Type1 Inactive DFGout 14.6243 12.5001 None -82.13, 150.25 -82.61, 0.2 -71.2, 148.66 192.27, 49.92 16.39, 43.73 in-na in 9.0934 Saltbr-na 999.0 HRD-in -91.88, -54.83 65.15, 26.24 na-out-none SNCaon out-none ActLoopNT-out 3.7145 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None CSO202,CSO260 XRAY 2.4 0.233 0.281 A 307.0 262.0 41 27 6 21 [[120, 380]] 1.0 6yg5 Homo sapiens STE_MAP2K7_HUMAN STE 2.4e-80 275.5 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 3WZUA O14733 104 402 419.0 1FM:60600 Type1 Inactive DFGout 11.7992 6.6541 None -93.22, 113.48 -84.76, 103.03 -136.57, -104.81 215.37, 93.4 104.1, 999.0 none-na none 999.0 Saltbr-na 999.0 HRD-out -25.62, 111.55 -64.83, -46.46 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_nnno APE10-dihe-na 999.0, -69.55 APE9-dihe-na -125.65, -59.15 APE8-dihe-out -72.37, 11.48 APE8-rot-na 285.95 APE67-dihe-in -63.78, -33.54 -102.86, -19.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.3239 None None None XRAY 3.01 0.24 0.322 A 324.0 270.0 29 27 13 14 [[120, 380]] 1.0 3wzu Homo sapiens STE_MAP2K7_HUMAN STE 2.9e-80 275.3 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 6YG6A O14733 103 403 419.0 OQ8:60502 Type2 Inactive DFGout 16.1841 8.3099 None -139.95, -178.26 -130.53, 97.33 -80.93, -18.66 197.5, 70.15 99.84, 999.0 out-na out 11.8197 Saltbr-na 9.0572 HRD-in -74.08, -54.03 80.87, -1.6 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_nnno APE10-dihe-na 999.0, 156.96 APE9-dihe-na -153.68, 151.67 APE8-dihe-in -133.13, 149.82 APE8-rot-na 44.78 APE67-dihe-out -157.98, 122.58 -86.76, 138.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 20.3416 S271D,T275D None None XRAY 2.15 0.205 0.239 A 307.0 284.0 17 27 13 14 [[120, 380]] 1.0 6yg6 Homo sapiens STE_MAP2K7_HUMAN STE 3.3e-80 275.1 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 6YG6B O14733 104 403 419.0 OQ8:60504 Type2 Inactive DFGout 16.2787 8.6873 None -139.8, 179.92 -130.12, 95.85 -78.51, -14.19 197.24, 65.37 105.19, 999.0 out-na out 11.2208 Saltbr-na 7.8821 HRD-in -78.17, -53.67 81.94, -0.01 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 171.84 APE8-dihe-in -146.43, 151.13 APE8-rot-na 48.74 APE67-dihe-out -158.28, 125.4 -86.76, 140.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 20.4249 S271D,T275D None None XRAY 2.15 0.205 0.239 B 307.0 281.0 19 27 12 15 [[120, 380]] 1.0 6yg6 Homo sapiens STE_MAP2K7_HUMAN STE 3.3e-80 275.1 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 6YG2A O14733 102 404 419.0 1E8:60513,8E8:60514 Allosteric,Type1.5_Front Inactive None 999.0 999.0 None -141.51, 164.72 -158.89, -8.67 -87.07, 69.85 999.0, 999.0 141.69, -6.89 in-na in 9.9753 Saltbr-na 8.41 HRD-in -58.05, -52.64 72.65, 3.0 na-out-none SNCaon out-none ActLoopNT-out 4.4332 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 29.92 APE8-rot-na 285.9 APE67-dihe-in -48.65, -40.74 -57.35, -36.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.181 0.23 A 307.0 290.0 13 27 14 13 [[120, 380]] 1.0 6yg2 Homo sapiens STE_MAP2K7_HUMAN STE 2.4e-80 275.5 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 2DYLA O14733 103 402 419.0 No_ligand No_ligand None DFGin 5.4945 14.595 BLAminus -110.0, 167.28 -3.39, 131.78 -126.62, 56.73 342.81, 59.02 -75.18, 24.89 in-na in 8.8064 Saltbr-na 3.4564 HRD-in -38.91, -44.57 67.82, 6.27 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -170.9 APE8-rot-na 261.07 APE67-dihe-in -82.69, -17.86 -87.14, -15.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S271D,T275D None None XRAY 2.45 0.217 0.283 A 318.0 272.0 28 27 13 14 [[120, 380]] 1.0 2dyl Homo sapiens STE_MAP2K7_HUMAN STE 3.7e-80 274.9 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 5Z1DA O14733 103 403 419.0 95U:60501 Type1 None DFGin 5.8572 14.5846 BLAminus -132.64, 165.55 65.51, 87.28 -111.34, 26.51 319.06, 84.39 -58.48, -30.36 in-na in 8.3569 Saltbr-na 4.0434 HRD-in -83.1, -42.1 68.08, 4.78 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiai APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 121.65 APE8-dihe-in -8.48, 107.0 APE8-rot-na 193.18 APE67-dihe-in -53.9, -37.87 -45.41, -42.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.9979 None None None XRAY 2.28 0.195 0.258 A 324.0 274.0 27 27 14 13 [[120, 380]] 1.0 5z1d Homo sapiens STE_MAP2K7_HUMAN STE 9.7e-80 273.6 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
MAP2K7 MP2K7_HUMAN 6YG3A O14733 103 400 419.0 6HF:60510 Type1 None DFGin 6.1952 14.5493 BLAminus -146.55, 178.23 54.3, 83.97 -103.73, 30.03 316.89, 91.95 -57.17, -29.89 in-na in 8.3452 Saltbr-na 3.3604 HRD-in -81.36, -52.29 76.4, 12.98 na-in-none SNCain in-none ActLoopNT-in 2.9822 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.05 0.191 0.235 A 307.0 265.0 33 27 8 19 [[120, 380]] 1.0 6yg3 Homo sapiens STE_MAP2K7_HUMAN STE 2.4e-80 275.5 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7

STE_MAP2K7 (Dual specificity mitogen-activated protein kinase kinase 7)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name