CMGC_CDK7 (Cyclin-dependent kinase 7)

Total number of chains: 66
Active chains: 19
Uniprot: CDK7_HUMAN
Kinase Domain Residues: 12 - 296
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 41 62.1% AF-P50613-K1A
DFGin None 16 24.2% 7EGC8
DFGin ABAminus 5 7.6% 7ENC8
None None 2 3.0% 8PYRA
DFGin BLAplus 1 1.5% 8P4ZA
DFGin BLBplus 1 1.5% 8P4ZB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
9HIYJ 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 10 - 310 0 None D97N Cyclin-dependent kinase 7
AF-P50613-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 4 - 303 0 None None Cyclin-dependent kinase 7
AF-P50613-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 4 - 303 0 None None Cyclin-dependent kinase 7
8ORMJ 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii V0G Type1 10 - 312 0 None None Cyclin-dependent kinase 7
8P6WJ 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii X2H Type1 10 - 310 0 None None Cyclin-dependent kinase 7
8P6XJ 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NS9 Type1 10 - 310 0 None None Cyclin-dependent kinase 7
8P6ZJ 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii X4L Type1 10 - 310 0 None None Cyclin-dependent kinase 7
8P70J 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii X4Q Type1 10 - 310 0 None None Cyclin-dependent kinase 7
8P71J 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii X4F Type1 10 - 310 0 None None Cyclin-dependent kinase 7
8P72J 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii X2Z Type1 10 - 310 0 None None Cyclin-dependent kinase 7
8P74J 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii X3Z Type1 10 - 310 0 None None Cyclin-dependent kinase 7
8P75J 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii X3Z Type1 10 - 310 0 None None Cyclin-dependent kinase 7
8P76J 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii X1W Type1 10 - 310 0 None None Cyclin-dependent kinase 7
8P78J 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 1QK Type1 10 - 310 0 None None Cyclin-dependent kinase 7
8PLZJ 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZQ6 Type1 10 - 310 0 None None Cyclin-dependent kinase 7
8S0RJ 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1H46 Type1 10 - 312 0 None None Cyclin-dependent kinase 7
8S0TJ 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YNK Type1 10 - 310 0 None None Cyclin-dependent kinase 7
7B5OJ 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii I74 Type1 10 - 311 0 None None Cyclin-dependent kinase 7
7B5QJ 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii I74 Type1 10 - 311 0 None None Cyclin-dependent kinase 7
6XBZJ 2.8 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 10 - 312 0 SEP164 None Cyclin-dependent kinase 7
7EGB8 3.3 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 10 - 312 0 None None Cyclin-dependent kinase 7
7ENC8 4.13 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 13 - 311 0 None None Cyclin-dependent kinase 7
7LBME 4.8 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 10 - 312 0 None None Cyclin-dependent kinase 7
7NVR8 4.5 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 10 - 312 0 None None Cyclin-dependent kinase 7
8R99A 1.81 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iooi ANP ATPlike 10 - 311 0 None W132R,S164D,T170E Cyclin-dependent kinase 7
8P6YJ 1.9 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 10 - 310 0 None None Cyclin-dependent kinase 7
9I9IJ 3.5 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 12 - 310 0 None None Cyclin-dependent kinase 7
9I9JJ 3.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iooi ADP ATPlike 11 - 310 0 None None Cyclin-dependent kinase 7
9I9KJ 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iooi ADP ATPlike 10 - 310 0 None None Cyclin-dependent kinase 7
9QCVJ 2.5 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iooi ANP ATPlike 10 - 346 0 None None Cyclin-dependent kinase 7
9SKQJ 3.4 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iooi ANP ATPlike 9 - 346 0 None None Cyclin-dependent kinase 7
8R9SA 2.78 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_niii PE3, PE3, YPK Allosteric, Allosteric, Type1 8 - 312 0 None W132R,S164D,T170E Cyclin-dependent kinase 7
8BVW8 4.0 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iioi No_ligand No_ligand 13 - 311 0 None None Cyclin-dependent kinase 7
8P79J 1.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 10 - 310 0 None None Cyclin-dependent kinase 7
9QCXJ 2.6 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iooi No_ligand No_ligand 9 - 346 0 None None Cyclin-dependent kinase 7
8R9AA 1.71 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iooi I74 Type1 10 - 311 0 None W132R,S164D,T170E Cyclin-dependent kinase 7
8R9OA 2.22 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnni YN3 Type1 10 - 312 0 None W132R,S164D,T170E Cyclin-dependent kinase 7
8R9OB 2.22 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_nooi YN3 Type1 10 - 312 0 None W132R,S164D,T170E Cyclin-dependent kinase 7
8R9UA 1.937 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoi YNK Type1 10 - 311 0 None W132R,S164D,T170E Cyclin-dependent kinase 7
8R9UB 1.937 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoi YNK Type1 10 - 311 0 None W132R,S164D,T170E Cyclin-dependent kinase 7
8P6VJ 1.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii I74 Type1 10 - 310 0 None None Cyclin-dependent kinase 7
8P77J 1.8 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii I73 Type1 10 - 310 0 None None Cyclin-dependent kinase 7
8P7LJ 2.1 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_nnii WD9 Type1 10 - 311 0 None None Cyclin-dependent kinase 7
9HJ0J 2.6 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii I74 Type1 12 - 310 0 None D97N Cyclin-dependent kinase 7
8P73J 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii X50, X58 Type1, Type1 10 - 310 0 None None Cyclin-dependent kinase 7
8P4ZA 2.75 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaooi APEdist_nnno WZ8 Type1 11 - 310 0 None None Cyclin-dependent kinase 7
8P4ZB 2.75 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooi APEdist_nnno WZ8 Type1 10 - 310 0 None None Cyclin-dependent kinase 7
1UA2A 3.02 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoii APEdist_oooo ATP ATPlike 13 - 311 0 TPO170 None Cyclin-dependent kinase 7
1UA2B 3.02 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo ATP ATPlike 13 - 311 0 TPO170 None Cyclin-dependent kinase 7
1UA2C 3.02 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ATP ATPlike 13 - 311 0 TPO170 None Cyclin-dependent kinase 7
1UA2D 3.02 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ATP ATPlike 13 - 311 0 TPO170 None Cyclin-dependent kinase 7
8R9BA 2.21 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo ANP ATPlike 1 - 311 0 None S164D,T170E Cyclin-dependent kinase 7
8R9BB 2.21 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo ANP ATPlike 3 - 310 0 None S164D,T170E Cyclin-dependent kinase 7
8R9BC 2.21 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoii APEdist_nnoo ANP ATPlike 8 - 311 0 None S164D,T170E Cyclin-dependent kinase 7
8R9BD 2.21 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooi APEdist_nnoo ANP ATPlike 9 - 311 0 None S164D,T170E Cyclin-dependent kinase 7
8R9SB 2.78 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioo APEdist_niii PE3, PE3, YPK Allosteric, Allosteric, Type1 9 - 312 0 None W132R,S164D,T170E Cyclin-dependent kinase 7
6O9L8 7.2 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaiii APEdist_iioi No_ligand No_ligand 13 - 311 0 None None Cyclin-dependent kinase 7
7EGC8 3.9 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 13 - 310 0 None None Cyclin-dependent kinase 7
7ENA8 4.07 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 13 - 311 0 None None Cyclin-dependent kinase 7
8BYQ8 4.1 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_oooi No_ligand No_ligand 13 - 310 0 None None Cyclin-dependent kinase 7
8GXQHI 5.04 Inactive DFGin‑None in-na in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 13 - 311 0 None K41A Cyclin-dependent kinase 7
8GXSHI 4.16 Inactive DFGin‑None in-na in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 13 - 311 0 None K41A Cyclin-dependent kinase 7
6XD3J 3.3 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaioi APEdist_iiii V0G Type1 10 - 312 0 SEP164 None Cyclin-dependent kinase 7
8PYRA 2.15 Inactive None‑None none-none in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 46 - 311 0 SEP164,TPO170 None Cyclin-dependent kinase 7
8PYRE 2.15 Inactive None‑None none-none in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 51 - 310 0 SEP164,TPO170 None Cyclin-dependent kinase 7
9HIXJ 2.6 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_niii V0G Type1 10 - 312 0 None D97N Cyclin-dependent kinase 7

CMGC_CDK7 (Cyclin-dependent kinase 7)

Total number of chains: 70
Active chains: 19
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 41 58.6% AF-P50613-K1A
DFGin None 18 25.7% 6Z4XB
DFGin ABAminus 7 10.0% 6Z3UB
None None 2 2.9% 8PYRA
DFGin BLAplus 1 1.4% 8P4ZA
DFGin BLBplus 1 1.4% 8P4ZB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
G0SFC6_CHATD 6Z3UB 2.6 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 78 - 399 0 None None Protein kinase domain-containing protein Chaetomium thermophilum
G0SFC6_CHATD 6Z3UE 2.6 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 77 - 399 0 None None Protein kinase domain-containing protein Chaetomium thermophilum
G0SFC6_CHATD 6Z4XB 2.98 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 78 - 399 0 None None Protein kinase domain-containing protein Chaetomium thermophilum
G0SFC6_CHATD 6Z4XE 2.98 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 77 - 399 0 None None Protein kinase domain-containing protein Chaetomium thermophilum
CDK7_HUMAN 9HIYJ 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 10 - 310 0 None D97N Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN AF-P50613-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 4 - 303 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN AF-P50613-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 4 - 303 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8ORMJ 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii V0G Type1 10 - 312 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8P6WJ 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii X2H Type1 10 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8P6XJ 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NS9 Type1 10 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8P6ZJ 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii X4L Type1 10 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8P70J 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii X4Q Type1 10 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8P71J 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii X4F Type1 10 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8P72J 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii X2Z Type1 10 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8P74J 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii X3Z Type1 10 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8P75J 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii X3Z Type1 10 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8P76J 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii X1W Type1 10 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8P78J 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 1QK Type1 10 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8PLZJ 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZQ6 Type1 10 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8S0RJ 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1H46 Type1 10 - 312 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8S0TJ 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YNK Type1 10 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 7B5OJ 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii I74 Type1 10 - 311 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 7B5QJ 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii I74 Type1 10 - 311 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 6XBZJ 2.8 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 10 - 312 0 SEP164 None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 7EGB8 3.3 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 10 - 312 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 7ENC8 4.13 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 13 - 311 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 7LBME 4.8 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 10 - 312 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 7NVR8 4.5 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 10 - 312 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8R99A 1.81 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iooi ANP ATPlike 10 - 311 0 None W132R,S164D,T170E Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8P6YJ 1.9 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 10 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 9I9IJ 3.5 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 12 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 9I9JJ 3.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iooi ADP ATPlike 11 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 9I9KJ 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iooi ADP ATPlike 10 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 9QCVJ 2.5 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iooi ANP ATPlike 10 - 346 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 9SKQJ 3.4 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iooi ANP ATPlike 9 - 346 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8R9SA 2.78 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_niii PE3, PE3, YPK Allosteric, Allosteric, Type1 8 - 312 0 None W132R,S164D,T170E Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8BVW8 4.0 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iioi No_ligand No_ligand 13 - 311 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8P79J 1.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 10 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 9QCXJ 2.6 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iooi No_ligand No_ligand 9 - 346 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8R9AA 1.71 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iooi I74 Type1 10 - 311 0 None W132R,S164D,T170E Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8R9OA 2.22 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnni YN3 Type1 10 - 312 0 None W132R,S164D,T170E Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8R9OB 2.22 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_nooi YN3 Type1 10 - 312 0 None W132R,S164D,T170E Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8R9UA 1.937 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoi YNK Type1 10 - 311 0 None W132R,S164D,T170E Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8R9UB 1.937 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoi YNK Type1 10 - 311 0 None W132R,S164D,T170E Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8P6VJ 1.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii I74 Type1 10 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8P77J 1.8 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii I73 Type1 10 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8P7LJ 2.1 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_nnii WD9 Type1 10 - 311 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 9HJ0J 2.6 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii I74 Type1 12 - 310 0 None D97N Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8P73J 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii X50, X58 Type1, Type1 10 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8P4ZA 2.75 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaooi APEdist_nnno WZ8 Type1 11 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8P4ZB 2.75 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooi APEdist_nnno WZ8 Type1 10 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 1UA2A 3.02 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoii APEdist_oooo ATP ATPlike 13 - 311 0 TPO170 None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 1UA2B 3.02 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo ATP ATPlike 13 - 311 0 TPO170 None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 1UA2C 3.02 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ATP ATPlike 13 - 311 0 TPO170 None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 1UA2D 3.02 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ATP ATPlike 13 - 311 0 TPO170 None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8R9BA 2.21 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo ANP ATPlike 1 - 311 0 None S164D,T170E Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8R9BB 2.21 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo ANP ATPlike 3 - 310 0 None S164D,T170E Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8R9BC 2.21 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoii APEdist_nnoo ANP ATPlike 8 - 311 0 None S164D,T170E Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8R9BD 2.21 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooi APEdist_nnoo ANP ATPlike 9 - 311 0 None S164D,T170E Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8R9SB 2.78 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioo APEdist_niii PE3, PE3, YPK Allosteric, Allosteric, Type1 9 - 312 0 None W132R,S164D,T170E Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 6O9L8 7.2 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaiii APEdist_iioi No_ligand No_ligand 13 - 311 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 7EGC8 3.9 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 13 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 7ENA8 4.07 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 13 - 311 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8BYQ8 4.1 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_oooi No_ligand No_ligand 13 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8GXQHI 5.04 Inactive DFGin‑None in-na in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 13 - 311 0 None K41A Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8GXSHI 4.16 Inactive DFGin‑None in-na in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 13 - 311 0 None K41A Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 6XD3J 3.3 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaioi APEdist_iiii V0G Type1 10 - 312 0 SEP164 None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8PYRA 2.15 Inactive None‑None none-none in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 46 - 311 0 SEP164,TPO170 None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 8PYRE 2.15 Inactive None‑None none-none in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 51 - 310 0 SEP164,TPO170 None Cyclin-dependent kinase 7 Homo sapiens
CDK7_HUMAN 9HIXJ 2.6 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_niii V0G Type1 10 - 312 0 None D97N Cyclin-dependent kinase 7 Homo sapiens

CMGC_CDK7 (Cyclin-dependent kinase 7)

Total number of chains: 4
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 50.0% 6Z3UB
DFGin None 2 50.0% 6Z4XB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
G0SFC6_CHATD 6Z3UB 2.6 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 78 - 399 0 None None Protein kinase domain-containing protein Chaetomium thermophilum
G0SFC6_CHATD 6Z3UE 2.6 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 77 - 399 0 None None Protein kinase domain-containing protein Chaetomium thermophilum
G0SFC6_CHATD 6Z4XB 2.98 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 78 - 399 0 None None Protein kinase domain-containing protein Chaetomium thermophilum
G0SFC6_CHATD 6Z4XE 2.98 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 77 - 399 0 None None Protein kinase domain-containing protein Chaetomium thermophilum