CMGC_CDK7 (Cyclin-dependent kinase 7)

Total number of chains: 66
Active chains: 19
Family: CMGC
Uniprot: CDK7_HUMAN
Kinase Domain Residues: 12 - 296
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 41 62.1% AF-P50613-K1A
DFGin None 16 24.2% 7EGC8
DFGin ABAminus 5 7.6% 7ENC8
None None 2 3.0% 8PYRA
DFGin BLAplus 1 1.5% 8P4ZA
DFGin BLBplus 1 1.5% 8P4ZB

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
9HIYJ 10 310 346.0 AGS:60401 ATPlike Active DFGin 6.727 15.718 BLAminus -144.39, -174.23 58.17, 64.72 -87.83, 23.91 281.92, 72.77 -77.85, -11.75 in-in in 8.542 Saltbr-in 3.5 HRD-in -67.31, -50.64 65.74, 8.28 in-in-in SNCiii in-in ActLoopNT-in 2.733 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.25, 164.09 APE9-dihe-na 67.64, 142.62 APE8-dihe-in -59.57, 146.87 APE8-rot-in 317.63 APE67-dihe-in -64.96, -18.05 -61.86, -38.17 APE12-dist-in 13.579 APE11-dist-in 11.322 APE10-dist-in 6.933 APE9-dist-in 3.352 D97N None None EM 2.3 999.0 999.0 J 349 287 14 0 0 3 [[12, 295]] 1.0 9hiy CMGC_CDK7_HUMAN CMGC 1.8e-78 271.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
AF-P50613-K1A 4 303 346.0 No_ligand No_ligand Active DFGin 6.947 14.651 BLAminus -139.37, 174.94 56.44, 65.77 -76.49, 16.79 285.4, 76.38 -56.51, -40.53 in-in in 9.069 Saltbr-in 2.781 HRD-in -73.36, -47.54 60.11, 19.26 in-in-in SNCiii in-in ActLoopNT-in 2.926 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.44, 167.69 APE9-dihe-na 62.53, 130.0 APE8-dihe-in -57.01, 134.36 APE8-rot-in 299.11 APE67-dihe-in -63.68, -24.26 -47.72, -44.22 APE12-dist-in 12.878 APE11-dist-in 10.698 APE10-dist-in 6.323 APE9-dist-in 3.385 None None None AF2 -1.0 1.0 1.0 A 301 301 0 0 0 0 [[12, 295]] 1.0 AF-P50613-K1 CMGC_CDK7_HUMAN CMGC 9.5e-79 272.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
AF-P50613-K3A 4 303 346.0 No_ligand No_ligand Active DFGin 6.865 14.636 BLAminus -137.06, 174.38 58.01, 69.42 -79.21, 16.29 289.72, 83.63 -59.38, -30.4 in-in in 9.199 Saltbr-in 2.9 HRD-in -77.13, -48.76 60.55, 22.8 in-in-in SNCiii in-in ActLoopNT-in 2.847 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.28, 162.28 APE9-dihe-na 61.56, 143.42 APE8-dihe-in -57.15, 134.76 APE8-rot-in 295.02 APE67-dihe-in -64.26, -20.94 -45.41, -43.91 APE12-dist-in 12.56 APE11-dist-in 10.514 APE10-dist-in 6.324 APE9-dist-in 3.674 None None None AF2 -1.0 1.0 1.0 A 301 301 0 0 0 0 [[12, 295]] 1.0 AF-P50613-K3 CMGC_CDK7_HUMAN CMGC 9.5e-79 272.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8ORMJ 10 312 346.0 V0G:60401 Type1 Active DFGin 6.785 15.213 BLAminus -141.24, -179.07 57.58, 66.36 -85.75, 20.07 280.87, 76.67 -67.32, -17.72 in-in in 7.944 Saltbr-in 2.798 HRD-in -68.87, -49.12 65.49, 10.0 in-in-in SNCiii in-in ActLoopNT-in 2.723 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -64.18, 162.48 APE9-dihe-na 68.43, 133.67 APE8-dihe-in -60.65, 148.97 APE8-rot-in 313.74 APE67-dihe-in -63.64, -17.24 -60.73, -41.91 APE12-dist-in 13.184 APE11-dist-in 10.147 APE10-dist-in 6.535 APE9-dist-in 3.139 None None None EM 1.9 999.0 999.0 J 349 288 15 0 0 0 [[12, 295]] 1.0 8orm CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8P6WJ 10 310 346.0 X2H:60401 Type1 Active DFGin 6.842 15.16 BLAminus -137.23, -179.69 59.15, 67.62 -86.16, 22.96 283.72, 72.83 -68.87, -18.76 in-in in 7.993 Saltbr-in 2.6 HRD-in -71.82, -52.01 68.31, 9.83 in-in-in SNCiii in-in ActLoopNT-in 2.828 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -70.04, 165.31 APE9-dihe-na 68.58, 140.54 APE8-dihe-in -58.26, 142.95 APE8-rot-in 296.58 APE67-dihe-in -61.43, -27.53 -59.59, -38.5 APE12-dist-in 13.237 APE11-dist-in 10.523 APE10-dist-in 6.652 APE9-dist-in 3.261 None None None EM 1.9 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p6w CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8P6XJ 10 310 346.0 NS9:60401 Type1 Active DFGin 6.851 14.813 BLAminus -135.05, 178.22 58.13, 67.79 -85.98, 19.26 285.9, 76.96 -64.86, -16.71 in-in in 7.825 Saltbr-in 2.914 HRD-in -71.27, -49.07 64.89, 10.59 in-in-in SNCiii in-in ActLoopNT-in 2.72 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.37, 162.4 APE9-dihe-na 67.39, 142.34 APE8-dihe-in -59.13, 147.28 APE8-rot-in 319.82 APE67-dihe-in -62.51, -24.45 -59.1, -40.68 APE12-dist-in 13.227 APE11-dist-in 10.943 APE10-dist-in 6.835 APE9-dist-in 3.218 None None None EM 1.9 999.0 999.0 J 349 287 14 0 0 0 [[12, 295]] 1.0 8p6x CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8P6ZJ 10 310 346.0 X4L:60401 Type1 Active DFGin 6.845 15.162 BLAminus -137.28, -176.81 56.96, 64.2 -83.99, 20.83 280.3, 71.49 -69.63, -17.27 in-in in 7.953 Saltbr-in 2.775 HRD-in -65.96, -49.05 64.06, 7.7 in-in-in SNCiii in-in ActLoopNT-in 2.704 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.3, 163.0 APE9-dihe-na 69.25, 136.79 APE8-dihe-in -58.74, 147.61 APE8-rot-in 317.24 APE67-dihe-in -63.74, -16.65 -59.48, -42.34 APE12-dist-in 13.319 APE11-dist-in 10.889 APE10-dist-in 6.752 APE9-dist-in 3.26 None None None EM 2.1 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p6z CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8P70J 10 310 346.0 X4Q:60401 Type1 Active DFGin 6.874 15.092 BLAminus -142.71, -177.59 56.15, 66.23 -84.04, 19.36 281.9, 75.11 -68.69, -16.49 in-in in 7.938 Saltbr-in 3.512 HRD-in -68.82, -48.77 64.26, 11.24 in-in-in SNCiii in-in ActLoopNT-in 2.595 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -66.04, 164.02 APE9-dihe-na 68.08, 131.62 APE8-dihe-in -58.96, 140.51 APE8-rot-in 280.59 APE67-dihe-in -61.53, -26.64 -53.74, -37.34 APE12-dist-in 13.015 APE11-dist-in 10.084 APE10-dist-in 6.386 APE9-dist-in 3.389 None None None EM 2.0 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p70 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8P71J 10 310 346.0 X4F:60401 Type1 Active DFGin 6.832 15.304 BLAminus -139.46, 179.9 57.59, 64.02 -82.45, 17.71 282.17, 74.47 -64.72, -19.22 in-in in 8.103 Saltbr-in 2.694 HRD-in -67.33, -49.46 65.63, 5.51 in-in-in SNCiii in-in ActLoopNT-in 2.639 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.68, 168.49 APE9-dihe-na 67.33, 140.05 APE8-dihe-in -60.3, 143.93 APE8-rot-in 294.53 APE67-dihe-in -61.0, -25.19 -55.87, -41.76 APE12-dist-in 13.411 APE11-dist-in 11.192 APE10-dist-in 6.803 APE9-dist-in 3.276 None None None EM 2.0 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p71 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8P72J 10 310 346.0 X2Z:60401 Type1 Active DFGin 6.81 15.179 BLAminus -130.9, -176.92 58.16, 64.29 -83.54, 19.02 283.95, 72.61 -67.67, -15.09 in-in in 7.825 Saltbr-in 3.159 HRD-in -69.91, -48.69 65.53, 7.3 in-in-in SNCiii in-in ActLoopNT-in 2.659 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.29, 167.52 APE9-dihe-na 66.45, 136.14 APE8-dihe-in -56.02, 147.06 APE8-rot-in 307.2 APE67-dihe-in -65.26, -13.33 -60.11, -40.4 APE12-dist-in 13.222 APE11-dist-in 11.182 APE10-dist-in 6.764 APE9-dist-in 3.319 None None None EM 1.9 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p72 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8P74J 10 310 346.0 X3Z:60401 Type1 Active DFGin 6.861 15.35 BLAminus -126.73, -179.0 57.96, 65.75 -84.45, 17.34 284.54, 71.79 -65.15, -14.93 in-in in 8.007 Saltbr-in 3.583 HRD-in -66.93, -50.55 65.6, 8.65 in-in-in SNCiii in-in ActLoopNT-in 2.713 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -69.08, 167.42 APE9-dihe-na 68.9, 135.74 APE8-dihe-in -59.35, 143.48 APE8-rot-in 303.84 APE67-dihe-in -62.59, -20.42 -57.54, -39.85 APE12-dist-in 13.339 APE11-dist-in 10.73 APE10-dist-in 6.635 APE9-dist-in 3.308 None None None EM 2.2 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p74 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8P75J 10 310 346.0 X3Z:60401 Type1 Active DFGin 6.779 15.023 BLAminus -128.38, -178.74 57.34, 65.53 -84.63, 21.61 285.86, 73.49 -66.63, -20.58 in-in in 8.05 Saltbr-in 3.528 HRD-in -67.27, -50.27 64.07, 11.38 in-in-in SNCiii in-in ActLoopNT-in 2.689 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -63.45, 162.65 APE9-dihe-na 66.45, 130.41 APE8-dihe-in -60.91, 145.09 APE8-rot-in 289.58 APE67-dihe-in -61.8, -23.53 -52.32, -42.29 APE12-dist-in 12.784 APE11-dist-in 10.01 APE10-dist-in 6.403 APE9-dist-in 3.259 None None None EM 2.0 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p75 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8P76J 10 310 346.0 X1W:60401 Type1 Active DFGin 6.683 15.24 BLAminus -132.14, -176.12 57.5, 64.48 -83.86, 23.79 282.12, 75.12 -69.62, -20.7 in-in in 8.284 Saltbr-in 2.994 HRD-in -66.77, -49.39 65.46, 6.65 in-in-in SNCiii in-in ActLoopNT-in 2.769 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.7, 165.52 APE9-dihe-na 69.09, 136.44 APE8-dihe-in -57.06, 139.28 APE8-rot-in 298.41 APE67-dihe-in -63.31, -19.63 -54.89, -39.03 APE12-dist-in 13.406 APE11-dist-in 11.067 APE10-dist-in 6.623 APE9-dist-in 3.228 None None None EM 2.0 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p76 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8P78J 10 310 346.0 1QK:60401 Type1 Active DFGin 6.793 15.129 BLAminus -125.5, -177.03 58.99, 68.9 -87.31, 18.63 284.93, 69.97 -66.72, -11.37 in-in in 7.895 Saltbr-in 3.121 HRD-in -73.67, -52.36 67.02, 10.71 in-in-in SNCiii in-in ActLoopNT-in 2.905 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.06, 163.93 APE9-dihe-na 68.47, 139.58 APE8-dihe-in -57.78, 143.69 APE8-rot-in 300.23 APE67-dihe-in -60.36, -28.84 -57.18, -42.92 APE12-dist-in 13.384 APE11-dist-in 11.166 APE10-dist-in 6.835 APE9-dist-in 3.247 None None None EM 1.9 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p78 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8PLZJ 10 310 346.0 ZQ6:60401 Type1 Active DFGin 6.801 15.115 BLAminus -136.55, 179.3 59.71, 67.62 -86.75, 25.05 283.25, 72.9 -71.18, -16.84 in-in in 7.871 Saltbr-in 2.737 HRD-in -68.72, -50.76 66.06, 11.17 in-in-in SNCiii in-in ActLoopNT-in 2.754 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -67.79, 164.71 APE9-dihe-na 69.95, 130.48 APE8-dihe-in -55.57, 142.92 APE8-rot-in 302.79 APE67-dihe-in -63.23, -18.36 -51.64, -46.88 APE12-dist-in 13.166 APE11-dist-in 11.098 APE10-dist-in 6.613 APE9-dist-in 3.401 None None None EM 1.9 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8plz CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8S0RJ 10 312 346.0 A1H46:60401 Type1 Active DFGin 6.968 15.08 BLAminus -144.73, 176.22 56.72, 75.17 -85.01, 0.75 274.16, 82.98 -56.16, -16.18 in-in in 7.998 Saltbr-in 3.129 HRD-in -69.19, -40.44 59.81, 4.35 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -54.8, 150.59 APE9-dihe-na 54.66, 139.98 APE8-dihe-in -61.46, 112.88 APE8-rot-in 300.57 APE67-dihe-in -61.63, -25.36 -29.17, -41.93 APE12-dist-in 12.445 APE11-dist-in 10.691 APE10-dist-in 6.798 APE9-dist-in 3.446 None None None EM 2.4 999.0 999.0 J 349 298 5 0 0 0 [[12, 295]] 1.0 8s0r CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8S0TJ 10 310 346.0 YNK:401 Type1 Active DFGin 7.036 15.153 BLAminus -155.14, 160.15 71.15, 63.8 -77.32, 14.33 280.99, 80.55 -67.17, -20.96 in-in in 7.547 Saltbr-in 3.069 HRD-in -68.72, -39.05 53.9, 20.09 in-in-in SNCiii in-in ActLoopNT-in 2.75 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -77.18, 165.14 APE9-dihe-na 66.79, 123.95 APE8-dihe-in -58.64, 137.09 APE8-rot-in 295.11 APE67-dihe-in -64.73, -14.43 -51.73, -38.67 APE12-dist-in 13.283 APE11-dist-in 10.31 APE10-dist-in 6.541 APE9-dist-in 3.475 None None None EM 2.3 999.0 999.0 J 349 291 10 0 0 4 [[12, 295]] 1.0 8s0t CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
7B5OJ 10 311 346.0 I74:401 Type1 Active DFGin 6.72 14.798 BLAminus -137.92, -176.06 57.22, 65.94 -88.49, 25.05 285.22, 78.36 -71.06, -17.84 in-in in 8.0 Saltbr-in 3.37 HRD-in -61.91, -52.8 71.0, 10.09 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.65, -14.02 APE9-dihe-na -115.61, 138.37 APE8-dihe-in -48.22, 125.52 APE8-rot-in 295.73 APE67-dihe-in -68.0, -19.41 -43.31, -41.08 APE12-dist-in 12.958 APE11-dist-in 11.205 APE10-dist-in 6.663 APE9-dist-in 3.882 None None None EM 2.5 999.0 999.0 J 391 297 5 0 0 0 [[12, 295]] 1.0 7b5o CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
7B5QJ 10 311 346.0 I74:401 Type1 Active DFGin 6.836 14.899 BLAminus -147.46, 168.74 68.04, 74.93 -88.01, 20.02 281.19, 87.5 -69.68, -22.04 in-in in 7.944 Saltbr-in 3.037 HRD-in -66.27, -47.47 66.27, 29.92 in-in-in SNCiii in-in ActLoopNT-in 2.827 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.41, 51.31 APE9-dihe-na -157.4, 148.85 APE8-dihe-in -54.71, 127.13 APE8-rot-in 301.04 APE67-dihe-in -66.36, -17.91 -39.91, -44.29 APE12-dist-in 12.843 APE11-dist-in 10.813 APE10-dist-in 6.336 APE9-dist-in 4.073 None None None EM 2.5 999.0 999.0 J 391 297 5 0 0 0 [[12, 295]] 1.0 7b5q CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
6XBZJ 10 312 346.0 AGS:402 ATPlike Inactive DFGin 6.575 15.403 ABAminus -82.2, -66.45 -124.23, 139.62 -119.21, 25.52 290.81, 70.1 -71.19, -16.45 in-out in 8.0 Saltbr-out 4.8 HRD-out -77.12, 93.04 -84.92, 20.14 out-in-in SNCoii in-in ActLoopNT-in 2.804 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -98.95, 83.93 APE9-dihe-na -171.97, 152.98 APE8-dihe-in -55.47, 134.49 APE8-rot-in 286.18 APE67-dihe-in -62.05, -27.13 -54.66, -43.29 APE12-dist-in 13.356 APE11-dist-in 11.035 APE10-dist-in 6.035 APE9-dist-in 3.343 None SEP164 SEP164 EM 2.8 999.0 999.0 J 391 298 5 0 0 0 [[12, 295]] 1.0 6xbz CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
7EGB8 10 312 346.0 No_ligand No_ligand Inactive DFGin 6.574 15.403 ABAminus -82.12, -66.54 -124.17, 139.82 -119.41, 25.53 290.76, 70.02 -71.23, -16.48 in-out in 7.999 Saltbr-out 4.8 HRD-out -77.22, 93.3 -85.15, 20.16 out-in-in SNCoii in-in ActLoopNT-in 2.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -98.86, 83.92 APE9-dihe-na -172.07, 152.96 APE8-dihe-in -55.37, 134.47 APE8-rot-in 286.2 APE67-dihe-in -61.89, -27.4 -54.68, -43.45 APE12-dist-in 13.355 APE11-dist-in 11.034 APE10-dist-in 6.034 APE9-dist-in 3.342 None None None EM 3.3 999.0 999.0 8 346 298 5 0 0 0 [[12, 295]] 1.0 7egb CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
7ENC8 13 311 346.0 No_ligand No_ligand Inactive DFGin 6.514 16.247 ABAminus -64.35, -41.45 -112.45, 122.65 -107.33, 5.04 259.59, 77.14 -63.64, -39.66 in-out in 8.879 Saltbr-out 6.538 HRD-out -92.81, 108.56 -64.77, -42.72 out-in-in SNCoii in-in ActLoopNT-in 3.0 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -64.87, -37.92 APE9-dihe-na -64.09, 148.4 APE8-dihe-in -61.22, 145.32 APE8-rot-in 317.7 APE67-dihe-in -62.36, -38.05 -60.97, -38.88 APE12-dist-in 12.482 APE11-dist-in 11.676 APE10-dist-in 5.853 APE9-dist-in 4.072 None None None EM 4.13 999.0 999.0 8 346 299 1 0 0 0 [[12, 295]] 1.0 7enc CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
7LBME 10 312 346.0 No_ligand No_ligand Inactive DFGin 6.576 15.404 ABAminus -82.19, -66.37 -124.2, 139.55 -119.24, 25.56 290.85, 70.19 -71.05, -16.66 in-out in 8.002 Saltbr-out 4.8 HRD-out -77.15, 93.07 -84.86, 20.11 out-in-in SNCoii in-in ActLoopNT-in 2.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -99.1, 83.97 APE9-dihe-na -172.08, 152.92 APE8-dihe-in -55.28, 134.54 APE8-rot-in 286.18 APE67-dihe-in -61.92, -27.24 -54.87, -43.23 APE12-dist-in 13.358 APE11-dist-in 11.034 APE10-dist-in 6.038 APE9-dist-in 3.34 None None None EM 4.8 999.0 999.0 e 346 298 5 0 0 0 [[12, 295]] 1.0 7lbm CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
7NVR8 10 312 346.0 No_ligand No_ligand Inactive DFGin 6.575 15.404 ABAminus -82.15, -66.43 -124.26, 139.65 -119.26, 25.3 290.79, 70.05 -71.01, -16.51 in-out in 8.0 Saltbr-out 4.8 HRD-out -77.07, 93.05 -85.02, 20.22 out-in-in SNCoii in-in ActLoopNT-in 2.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -99.0, 83.91 APE9-dihe-na -171.85, 153.06 APE8-dihe-in -55.52, 134.56 APE8-rot-in 286.15 APE67-dihe-in -61.94, -27.21 -54.65, -43.34 APE12-dist-in 13.355 APE11-dist-in 11.032 APE10-dist-in 6.034 APE9-dist-in 3.342 None None None EM 4.5 999.0 999.0 8 346 298 5 0 0 0 [[12, 295]] 1.0 7nvr CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8R99A 10 311 346.0 ANP:401 ATPlike Inactive DFGin 6.921 15.074 BLAminus -136.18, 178.53 62.42, 80.05 -92.8, 32.41 285.07, 70.02 -64.17, -34.45 in-out in 9.457 Saltbr-out 5.606 HRD-in -70.53, -54.5 69.94, 6.7 out-in-out SNCoio in-out ActLoopNT-in 2.711 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -115.64, 148.75 APE9-dihe-na -60.57, 161.29 APE8-dihe-in -48.68, 142.11 APE8-rot-out 161.53 APE67-dihe-in -67.83, -20.09 -55.43, -38.94 APE12-dist-in 10.449 APE11-dist-out 5.162 APE10-dist-out 9.448 APE9-dist-in 3.715 W132R,S164D,T170E None None XRAY 1.81 0.178 0.22 A 371 283 19 0 0 0 [[12, 295]] 1.0 8r99 CMGC_CDK7_HUMAN CMGC 7.3e-78 269.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8P6YJ 10 310 346.0 AGS:60401 ATPlike Inactive DFGin 6.825 15.586 BLAminus -141.03, -177.14 58.28, 66.28 -86.35, 22.83 281.11, 73.93 -65.68, -18.8 in-out in 8.43 Saltbr-out 4.94 HRD-in -69.3, -48.75 64.3, 11.38 out-in-in SNCoii in-in ActLoopNT-in 2.794 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.65, 164.79 APE9-dihe-na 67.53, 137.74 APE8-dihe-in -59.47, 143.7 APE8-rot-in 312.32 APE67-dihe-in -62.79, -23.75 -56.89, -39.97 APE12-dist-in 13.313 APE11-dist-in 11.042 APE10-dist-in 6.646 APE9-dist-in 3.274 None None None EM 1.9 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p6y CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
9I9IJ 12 310 346.0 ADP:60401 ATPlike Inactive DFGin 6.598 15.148 BLAminus -154.26, -174.63 55.49, 63.23 -84.52, 21.08 280.13, 83.68 -62.16, -39.37 in-out in 8.62 Saltbr-out 4.724 HRD-in -68.87, -48.72 60.83, 9.92 out-in-out SNCoio in-out ActLoopNT-in 2.772 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -114.8, -59.65 APE9-dihe-na -71.54, 157.02 APE8-dihe-in -67.36, 161.57 APE8-rot-out 77.35 APE67-dihe-in -72.1, -35.43 -63.15, -31.03 APE12-dist-in 12.421 APE11-dist-in 11.24 APE10-dist-in 6.135 APE9-dist-in 3.716 None None None EM 3.5 999.0 999.0 J 391 294 5 0 0 0 [[12, 295]] 1.0 9i9i CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
9I9JJ 11 310 346.0 ADP:60401 ATPlike Inactive DFGin 7.046 15.511 BLAminus -142.62, -171.5 55.13, 63.56 -86.1, 20.41 278.63, 86.43 -73.48, -14.71 in-in in 8.475 Saltbr-in 3.262 HRD-in -63.57, -47.3 66.21, -0.54 in-in-out SNCiio in-out ActLoopNT-in 2.876 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -125.41, 160.15 APE9-dihe-na -72.91, 167.58 APE8-dihe-in -60.97, 159.12 APE8-rot-out 182.98 APE67-dihe-in -64.29, -19.96 -63.65, -26.45 APE12-dist-in 11.208 APE11-dist-out 5.341 APE10-dist-out 9.202 APE9-dist-in 4.033 None None None EM 3.1 999.0 999.0 J 391 290 10 0 0 5 [[12, 295]] 1.0 9i9j CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
9I9KJ 10 310 346.0 ADP:60401 ATPlike Inactive DFGin 6.867 15.16 BLAminus -144.56, -175.34 58.29, 64.88 -85.43, 20.68 280.65, 74.04 -68.51, -15.78 in-in in 8.403 Saltbr-in 3.423 HRD-in -66.35, -48.78 67.04, 4.57 in-in-out SNCiio in-out ActLoopNT-in 2.701 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -135.97, 162.75 APE9-dihe-na -69.89, 166.52 APE8-dihe-in -58.19, 147.77 APE8-rot-out 190.67 APE67-dihe-in -62.09, -25.1 -66.28, -24.83 APE12-dist-in 11.543 APE11-dist-out 5.948 APE10-dist-out 9.159 APE9-dist-in 3.891 None None None EM 2.4 999.0 999.0 J 391 301 0 0 0 0 [[12, 295]] 1.0 9i9k CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
9QCVJ 10 346 346.0 ANP:60401 ATPlike Inactive DFGin 6.812 15.58 BLAminus -138.8, -173.47 57.69, 63.92 -85.78, 14.86 277.56, 80.3 -62.91, -29.56 in-out in 8.304 Saltbr-out 4.707 HRD-in -68.14, -50.51 67.46, 2.9 out-in-out SNCoio in-out ActLoopNT-in 2.816 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -128.9, 162.73 APE9-dihe-na -74.02, 167.46 APE8-dihe-in -56.29, 150.3 APE8-rot-out 36.33 APE67-dihe-in -61.72, -30.52 -65.73, -24.93 APE12-dist-in 11.244 APE11-dist-out 5.34 APE10-dist-out 8.996 APE9-dist-in 3.808 None None None EM 2.5 999.0 999.0 J 391 307 0 0 0 0 [[12, 295]] 1.0 9qcv CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
9SKQJ 9 346 346.0 ANP:60401 ATPlike Inactive DFGin 7.089 16.079 BLAminus -134.4, -172.6 54.33, 63.76 -84.59, 21.04 273.82, 84.09 -68.06, -13.54 in-out in 8.685 Saltbr-out 3.604 HRD-in -66.63, -50.41 66.76, -1.97 out-in-out SNCoio in-out ActLoopNT-in 3.021 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -107.15, 155.19 APE9-dihe-na -64.85, 155.06 APE8-dihe-in -50.04, 149.57 APE8-rot-out 168.49 APE67-dihe-in -67.74, -34.69 -63.59, -17.75 APE12-dist-in 10.588 APE11-dist-out 5.67 APE10-dist-out 9.403 APE9-dist-in 3.987 None None None EM 3.4 999.0 999.0 J 391 306 0 0 0 0 [[12, 295]] 1.0 9skq CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8R9SA 8 312 346.0 PE3:401,PE3:403,YPK:404 Allosteric,Allosteric,Type1 Inactive DFGin 6.83 14.284 BLAminus -165.69, -175.97 45.67, 75.58 -92.62, 3.64 268.0, 93.26 -57.82, -22.21 in-in in 8.864 Saltbr-in 3.405 HRD-out -94.27, 75.87 -64.42, -8.36 in-in-out SNCiio in-out ActLoopNT-in 2.91 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_niii APE10-dihe-na -133.05, -48.43 APE9-dihe-na -60.09, 172.76 APE8-dihe-in -90.13, 61.97 APE8-rot-in 341.49 APE67-dihe-out -70.79, -35.04 59.18, -50.38 APE12-dist-none 999.0 APE11-dist-in 12.724 APE10-dist-in 6.865 APE9-dist-in 4.005 W132R,S164D,T170E None None XRAY 2.78 0.24 0.296 A 371 289 16 0 0 9 [[12, 295]] 1.0 8r9s CMGC_CDK7_HUMAN CMGC 7.3e-78 269.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8BVW8 13 311 346.0 No_ligand No_ligand Inactive DFGin 6.66 15.538 BLAminus -152.45, -166.11 61.66, 28.62 -60.07, -16.21 290.53, 102.36 -55.52, -24.06 in-out in 9.368 Saltbr-out 4.3 HRD-out -77.44, 94.01 -60.23, -12.16 out-in-out SNCoio in-out ActLoopNT-in 2.839 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -67.48, -28.49 APE9-dihe-na -125.08, 152.92 APE8-dihe-in -46.97, 127.53 APE8-rot-in 294.27 APE67-dihe-in -67.4, -7.76 -45.35, -46.98 APE12-dist-in 13.749 APE11-dist-in 12.261 APE10-dist-out 8.432 APE9-dist-in 3.87 None None None EM 4.0 999.0 999.0 8 346 299 1 0 0 0 [[12, 295]] 1.0 8bvw CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8P79J 10 310 346.0 No_ligand No_ligand Inactive DFGin 6.867 15.187 BLAminus -130.29, 173.2 63.24, 80.76 -93.9, 15.3 279.52, 73.29 -61.35, -20.82 in-in in 7.86 Saltbr-in 2.892 HRD-in -71.98, -55.93 71.02, 14.36 in-in-out SNCiio in-out ActLoopNT-in 2.8 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -74.02, 160.13 APE9-dihe-na 70.88, 124.77 APE8-dihe-in -52.58, 142.69 APE8-rot-out 173.92 APE67-dihe-in -66.31, -20.55 -52.74, -42.41 APE12-dist-in 13.195 APE11-dist-in 10.799 APE10-dist-in 6.528 APE9-dist-in 3.419 None None None EM 1.7 0.417 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p79 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
9QCXJ 9 346 346.0 No_ligand No_ligand Inactive DFGin 6.696 16.026 BLAminus -131.02, -177.03 59.81, 66.92 -86.78, 26.87 276.81, 73.59 -75.67, -10.97 in-out in 8.793 Saltbr-out 3.971 HRD-in -71.21, -46.31 66.3, 0.75 out-in-out SNCoio in-out ActLoopNT-in 2.753 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -103.75, 161.28 APE9-dihe-na -68.95, 168.1 APE8-dihe-in -56.3, 142.34 APE8-rot-out 173.25 APE67-dihe-in -65.83, -25.32 -64.61, -15.36 APE12-dist-in 10.486 APE11-dist-out 5.568 APE10-dist-out 9.089 APE9-dist-in 3.86 None None None EM 2.6 999.0 999.0 J 391 309 0 0 0 0 [[12, 295]] 1.0 9qcx CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8R9AA 10 311 346.0 I74:402 Type1 Inactive DFGin 6.943 14.473 BLAminus -142.15, 174.78 52.62, 81.62 -93.9, 33.78 285.76, 70.72 -69.96, -22.58 in-in in 9.259 Saltbr-in 3.38 HRD-in -71.93, -53.08 66.56, 13.4 in-in-out SNCiio in-out ActLoopNT-in 2.909 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -140.21, 140.61 APE9-dihe-na -58.82, 163.62 APE8-dihe-in -59.71, 143.88 APE8-rot-out 11.83 APE67-dihe-in -59.39, -21.26 -63.14, -34.89 APE12-dist-in 10.527 APE11-dist-out 5.215 APE10-dist-out 9.279 APE9-dist-in 3.808 W132R,S164D,T170E None None XRAY 1.71 0.224 0.294 A 371 285 17 0 0 0 [[12, 295]] 1.0 8r9a CMGC_CDK7_HUMAN CMGC 7.3e-78 269.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8R9OA 10 312 346.0 YN3:401 Type1 Inactive DFGin 7.01 15.105 BLAminus -129.64, 158.52 74.99, 81.61 -97.15, 34.08 294.95, 72.01 -80.74, -26.65 in-in in 9.621 Saltbr-in 3.468 HRD-in -72.69, -50.65 63.96, 5.37 in-in-out SNCiio in-out ActLoopNT-in 2.856 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 161.09 APE8-dihe-in -60.01, 150.23 APE8-rot-out 191.14 APE67-dihe-in -78.31, -17.17 -45.46, -39.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.342 W132R,S164D,T170E None None XRAY 2.22 0.258 0.344 A 371 276 27 0 0 10 [[12, 295]] 1.0 8r9o CMGC_CDK7_HUMAN CMGC 7.3e-78 269.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8R9OB 10 312 346.0 YN3:401 Type1 Inactive DFGin 7.041 14.997 BLAminus -138.7, 164.71 67.98, 80.71 -96.95, 34.33 295.63, 72.58 -80.3, -27.44 in-out in 9.485 Saltbr-out 4.29 HRD-in -72.39, -52.21 67.37, 12.01 out-in-out SNCoio in-out ActLoopNT-in 2.993 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooi APE10-dihe-na -159.84, 152.31 APE9-dihe-na -62.33, 160.72 APE8-dihe-in -60.74, 151.56 APE8-rot-out 191.25 APE67-dihe-in -79.05, -16.21 -45.43, -40.81 APE12-dist-none 999.0 APE11-dist-out 5.6 APE10-dist-out 8.982 APE9-dist-in 3.47 W132R,S164D,T170E None None XRAY 2.22 0.258 0.344 B 371 284 19 0 0 5 [[12, 295]] 1.0 8r9o CMGC_CDK7_HUMAN CMGC 7.3e-78 269.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8R9UA 10 311 346.0 YNK:401 Type1 Inactive DFGin 6.995 14.819 BLAminus -136.34, 177.25 64.26, 71.88 -94.29, 35.4 287.51, 80.17 -88.88, -17.75 in-in in 7.668 Saltbr-in 3.098 HRD-in -70.29, -39.89 54.29, 18.68 in-in-out SNCiio in-out ActLoopNT-in 2.94 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoi APE10-dihe-na 999.0, 95.99 APE9-dihe-na -33.61, 162.87 APE8-dihe-in -57.31, 147.69 APE8-rot-out 184.84 APE67-dihe-in -64.25, -23.63 -55.57, -38.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.455 APE9-dist-in 3.421 W132R,S164D,T170E None None XRAY 1.937 0.278 0.34 A 371 282 20 0 0 6 [[12, 295]] 1.0 8r9u CMGC_CDK7_HUMAN CMGC 7.3e-78 269.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8R9UB 10 311 346.0 YNK:401 Type1 Inactive DFGin 7.15 14.779 BLAminus -129.44, 175.01 67.08, 73.42 -94.57, 34.81 287.86, 79.6 -89.74, -17.02 in-in in 8.032 Saltbr-in 2.971 HRD-in -66.25, -52.35 71.96, 8.72 in-in-out SNCiio in-out ActLoopNT-in 2.814 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoi APE10-dihe-na 999.0, 137.47 APE9-dihe-na -49.58, 159.48 APE8-dihe-in -61.33, 140.09 APE8-rot-out 190.38 APE67-dihe-in -65.39, -24.05 -38.15, -47.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.157 APE9-dist-in 3.573 W132R,S164D,T170E None None XRAY 1.937 0.278 0.34 B 371 282 20 0 0 6 [[12, 295]] 1.0 8r9u CMGC_CDK7_HUMAN CMGC 7.3e-78 269.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8P6VJ 10 310 346.0 I74:60401 Type1 Inactive DFGin 6.792 15.477 BLAminus -127.02, 179.34 58.38, 68.34 -85.69, 24.62 280.05, 70.86 -67.13, -24.33 in-in in 8.222 Saltbr-in 3.215 HRD-in -67.24, -50.44 65.17, 9.5 in-in-out SNCiio in-out ActLoopNT-in 2.759 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -78.14, 165.38 APE9-dihe-na 66.68, 132.55 APE8-dihe-in -61.61, 157.58 APE8-rot-out 165.5 APE67-dihe-in -65.89, -16.75 -62.4, -42.77 APE12-dist-in 13.167 APE11-dist-in 10.687 APE10-dist-in 6.371 APE9-dist-in 3.36 None None None EM 1.9 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p6v CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8P77J 10 310 346.0 I73:60401 Type1 Inactive DFGin 6.742 15.27 BLAminus -132.45, -179.7 57.66, 63.66 -82.64, 21.59 281.33, 71.76 -68.21, -17.73 in-out in 8.084 Saltbr-out 3.673 HRD-in -69.39, -48.98 63.26, 11.42 out-in-in SNCoii in-in ActLoopNT-in 2.728 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -81.35, 165.5 APE9-dihe-na 68.99, 138.58 APE8-dihe-in -57.94, 141.68 APE8-rot-in 287.47 APE67-dihe-in -62.3, -27.5 -54.83, -40.88 APE12-dist-in 13.346 APE11-dist-in 10.91 APE10-dist-in 6.69 APE9-dist-in 3.315 None None None EM 1.8 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p77 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8P7LJ 10 311 346.0 WD9:401 Type1 Inactive DFGin 6.809 15.065 BLAminus -140.22, -179.03 56.2, 69.06 -86.55, 17.3 282.99, 80.61 -65.13, -17.22 in-out in 8.229 Saltbr-out 6.925 HRD-in -67.68, -49.89 66.46, 7.6 out-in-none SNCoin in-none ActLoopNT-in 2.819 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 121.08 APE9-dihe-na 72.05, 144.41 APE8-dihe-in -59.67, 147.38 APE8-rot-in 299.95 APE67-dihe-in -62.37, -38.92 -53.43, -44.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.68 APE9-dist-in 3.357 None None None EM 2.1 999.0 999.0 J 379 289 13 0 0 7 [[12, 295]] 1.0 8p7l CMGC_CDK7_HUMAN CMGC 2.1e-78 271.3 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
9HJ0J 12 310 346.0 I74:60401 Type1 Inactive DFGin 6.817 15.448 BLAminus -132.37, -171.58 55.11, 65.05 -85.31, 21.39 278.87, 69.2 -69.07, -20.48 in-out in 8.209 Saltbr-out 4.176 HRD-in -66.92, -50.4 64.01, 10.9 out-in-in SNCoii in-in ActLoopNT-in 2.645 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.73, 159.75 APE9-dihe-na 70.65, 131.86 APE8-dihe-in -50.1, 141.1 APE8-rot-in 304.02 APE67-dihe-in -65.42, -15.47 -59.14, -35.57 APE12-dist-in 13.42 APE11-dist-in 11.189 APE10-dist-in 6.88 APE9-dist-in 3.582 D97N None None EM 2.6 999.0 999.0 J 349 280 19 0 0 3 [[12, 295]] 1.0 9hj0 CMGC_CDK7_HUMAN CMGC 1.8e-78 271.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8P73J 10 310 346.0 X50:60401,X58:60402 Type1,Type1 Inactive DFGin 6.888 15.293 BLAminus -131.62, -179.54 56.98, 66.06 -83.52, 19.3 279.49, 76.56 -67.26, -17.21 in-in in 7.97 Saltbr-in 2.852 HRD-in -73.06, -52.64 65.19, 12.23 in-in-out SNCiio in-out ActLoopNT-in 2.735 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -64.33, 163.23 APE9-dihe-na 66.68, 129.91 APE8-dihe-in -65.37, 155.44 APE8-rot-out 179.35 APE67-dihe-in -64.93, -17.64 -61.55, -43.35 APE12-dist-in 13.216 APE11-dist-in 10.776 APE10-dist-in 6.623 APE9-dist-in 3.323 None None None EM 2.0 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p73 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8P4ZA 11 310 346.0 WZ8:60401 Type1 Inactive DFGin 7.012 14.218 BLAplus -138.13, 160.5 75.31, 59.87 -134.86, -7.56 51.2, 92.01 -94.58, 115.85 out-out out 14.21 Saltbr-out 13.177 HRD-in -71.48, -47.82 72.35, -9.13 out-out-out SNCooo out-out ActLoopNT-out 12.571 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -40.79 APE8-dihe-out -71.19, -16.02 APE8-rot-out 206.81 APE67-dihe-in -62.89, -27.85 -62.54, -32.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.596 None None None XRAY 2.75 0.226 0.251 A 304 272 28 0 0 13 [[12, 295]] 1.0 8p4z CMGC_CDK7_HUMAN CMGC 9.8e-79 272.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8P4ZB 10 310 346.0 WZ8:60401 Type1 Inactive DFGin 6.894 13.82 BLBplus -138.09, 160.99 74.49, 52.29 -133.73, 169.82 60.6, 81.42 53.64, 73.13 out-out out 13.833 Saltbr-out 12.649 HRD-in -70.02, -48.0 71.31, -8.1 out-out-out SNCooo out-out ActLoopNT-out 10.637 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -34.3 APE8-dihe-out -69.4, -20.94 APE8-rot-out 202.55 APE67-dihe-in -61.31, -27.25 -63.3, -32.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.735 None None None XRAY 2.75 0.226 0.251 B 304 277 24 0 0 12 [[12, 295]] 1.0 8p4z CMGC_CDK7_HUMAN CMGC 9.8e-79 272.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
1UA2A 13 311 346.0 ATP:381 ATPlike Inactive DFGin 3.838 15.074 None -72.36, 176.54 -63.29, 129.93 -58.5, 61.34 34.11, 88.78 62.95, -115.18 out-out out 13.014 Saltbr-out 13.633 HRD-out -71.94, 127.86 -111.75, 17.16 out-out-out SNCooo out-out ActLoopNT-out 10.781 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -60.17, 155.77 APE9-dihe-na -94.04, -36.01 APE8-dihe-out 80.52, 83.34 APE8-rot-in 310.15 APE67-dihe-in -70.12, 0.07 -111.89, 13.44 APE12-dist-out 21.608 APE11-dist-out 18.745 APE10-dist-out 20.457 APE9-dist-out 13.019 None TPO170 TPO170 XRAY 3.02 0.217 0.288 A 346 287 13 0 0 0 [[12, 295]] 1.0 1ua2 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
1UA2B 13 311 346.0 ATP:382 ATPlike Inactive DFGin 4.075 14.483 None -83.42, -165.13 -43.25, 135.34 -79.47, 27.14 49.47, 35.58 128.26, -117.59 out-out out 13.208 Saltbr-out 11.182 HRD-out -90.35, 54.77 -58.64, -3.2 out-out-out SNCooo out-out ActLoopNT-out 10.755 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -59.37, 128.97 APE9-dihe-na -70.17, -103.62 APE8-dihe-out 114.41, 132.59 APE8-rot-out 86.06 APE67-dihe-in -64.71, -6.03 -138.86, 19.47 APE12-dist-out 21.356 APE11-dist-out 17.939 APE10-dist-out 20.116 APE9-dist-out 13.119 None TPO170 TPO170 XRAY 3.02 0.217 0.288 B 346 287 13 0 0 0 [[12, 295]] 1.0 1ua2 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
1UA2C 13 311 346.0 ATP:383 ATPlike Inactive DFGin 4.377 15.832 None -69.53, 164.86 -53.4, 113.84 -55.09, 81.41 35.63, 74.81 38.07, -90.08 out-out out 14.291 Saltbr-out 13.35 HRD-out -90.81, 75.3 -67.23, 24.34 out-out-out SNCooo out-out ActLoopNT-out 10.725 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -61.3, 146.02 APE9-dihe-na -103.14, 168.98 APE8-dihe-in -149.98, 115.15 APE8-rot-in 317.59 APE67-dihe-in -70.34, -0.48 -115.08, 9.43 APE12-dist-out 21.995 APE11-dist-out 19.636 APE10-dist-out 20.119 APE9-dist-out 12.619 None TPO170 TPO170 XRAY 3.02 0.217 0.288 C 346 287 13 0 0 0 [[12, 295]] 1.0 1ua2 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
1UA2D 13 311 346.0 ATP:384 ATPlike Inactive DFGin 3.971 15.482 None -66.13, 178.54 -66.01, 128.6 -62.88, 66.21 38.44, 67.87 63.18, -97.8 out-out out 13.242 Saltbr-out 13.575 HRD-out -80.45, 94.07 -71.75, -5.97 out-out-out SNCooo out-out ActLoopNT-out 10.896 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.63, 129.76 APE9-dihe-na -71.09, 152.84 APE8-dihe-in -147.91, 130.69 APE8-rot-out 68.98 APE67-dihe-in -88.14, 9.58 -128.15, 23.18 APE12-dist-out 22.145 APE11-dist-out 18.845 APE10-dist-out 20.01 APE9-dist-out 12.657 None TPO170 TPO170 XRAY 3.02 0.217 0.288 D 346 287 13 0 0 0 [[12, 295]] 1.0 1ua2 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8R9BA 1 311 346.0 ANP:401 ATPlike Inactive DFGin 6.667 15.04 None -136.41, -179.13 75.36, -66.57 59.32, 16.33 291.11, 69.78 55.95, 32.69 out-out out 13.486 Saltbr-out 13.754 HRD-in -65.3, -54.78 73.94, 0.68 out-out-out SNCooo out-out ActLoopNT-out 12.55 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -74.63, 115.42 APE9-dihe-na -115.54, -2.31 APE8-dihe-out -56.05, -31.84 APE8-rot-out 157.42 APE67-dihe-in -63.34, -23.16 -66.49, -24.29 APE12-dist-out 18.002 APE11-dist-out 20.187 APE10-dist-out 16.086 APE9-dist-out 11.465 S164D,T170E None None XRAY 2.21 0.195 0.243 A 352 301 10 0 0 0 [[12, 295]] 1.0 8r9b CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8R9BB 3 310 346.0 ANP:402 ATPlike Inactive DFGin 6.563 15.084 None -126.22, 177.01 84.52, -73.28 65.77, 22.93 292.14, 76.04 47.33, 39.02 out-out out 13.607 Saltbr-out 11.882 HRD-in -71.08, -53.54 74.78, -6.63 out-out-out SNCooo out-out ActLoopNT-out 12.936 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -81.04, 115.32 APE9-dihe-na -115.04, 1.93 APE8-dihe-out -60.49, -32.76 APE8-rot-out 168.86 APE67-dihe-in -59.67, -24.77 -68.61, -28.01 APE12-dist-out 17.779 APE11-dist-out 20.186 APE10-dist-out 16.157 APE9-dist-out 11.416 S164D,T170E None None XRAY 2.21 0.195 0.243 B 352 298 10 0 0 0 [[12, 295]] 1.0 8r9b CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8R9BC 8 311 346.0 ANP:402 ATPlike Inactive DFGin 6.451 15.34 None -116.21, 176.78 77.39, -97.04 64.16, 26.01 311.61, 20.83 46.47, 58.36 out-out out 13.104 Saltbr-out 12.133 HRD-in -78.41, -55.45 77.67, -2.52 out-out-out SNCooo out-out ActLoopNT-out 12.922 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 132.76 APE9-dihe-na -87.2, -35.35 APE8-dihe-out -49.87, -35.32 APE8-rot-in 271.7 APE67-dihe-in -63.34, -21.13 -58.67, -34.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.928 APE9-dist-out 10.934 S164D,T170E None None XRAY 2.21 0.195 0.243 C 352 276 28 0 0 12 [[12, 295]] 1.0 8r9b CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8R9BD 9 311 346.0 ANP:402 ATPlike Inactive DFGin 5.186 15.529 None -119.23, -173.72 58.44, -119.7 56.58, 114.74 106.06, 59.9 70.5, -151.21 out-out out 13.062 Saltbr-out 12.354 HRD-in -80.52, -56.05 80.67, -8.56 out-out-out SNCooo out-out ActLoopNT-out 13.055 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -29.49 APE9-dihe-na -113.47, -32.42 APE8-dihe-out -62.11, -27.52 APE8-rot-out 75.68 APE67-dihe-in -62.12, -24.79 -50.05, -35.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.16 APE9-dist-out 11.156 S164D,T170E None None XRAY 2.21 0.195 0.243 D 352 277 26 0 0 10 [[12, 295]] 1.0 8r9b CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8R9SB 9 312 346.0 PE3:401,PE3:402,YPK:403 Allosteric,Allosteric,Type1 Inactive DFGin 6.661 14.137 None -136.72, -83.07 -78.7, 108.99 -96.75, 5.62 270.16, 92.75 -61.04, -22.45 in-in in 8.969 Saltbr-in 2.906 HRD-out -93.55, 75.1 -63.47, -8.59 in-in-out SNCiio in-out ActLoopNT-in 2.958 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_niii APE10-dihe-na -131.56, -46.56 APE9-dihe-na -57.97, 167.59 APE8-dihe-in -92.57, 68.94 APE8-rot-out 164.5 APE67-dihe-out -70.3, -34.85 61.12, -49.62 APE12-dist-none 999.0 APE11-dist-in 12.57 APE10-dist-in 6.741 APE9-dist-in 4.029 W132R,S164D,T170E None None XRAY 2.78 0.24 0.296 B 371 290 14 0 0 9 [[12, 295]] 1.0 8r9s CMGC_CDK7_HUMAN CMGC 7.3e-78 269.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
6O9L8 13 311 346.0 No_ligand No_ligand Inactive DFGin 7.798 15.312 None -95.81, -101.98 -119.05, 160.07 -109.44, 53.11 290.95, 162.54 -72.96, -5.74 out-out out 10.662 Saltbr-out 6.489 HRD-out -97.79, 80.29 -81.32, 54.89 out-in-out SNCoio in-out ActLoopNT-in 3.413 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -106.12, -175.8 APE9-dihe-na 68.22, 148.02 APE8-dihe-in -56.94, 134.18 APE8-rot-in 300.57 APE67-dihe-in -70.23, -40.86 -66.35, -19.39 APE12-dist-in 13.709 APE11-dist-in 13.799 APE10-dist-out 8.06 APE9-dist-in 5.088 None None None EM 7.2 999.0 999.0 8 346 299 1 0 0 0 [[12, 295]] 1.0 6o9l CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
7EGC8 13 310 346.0 No_ligand No_ligand Inactive DFGin 5.879 15.554 None -116.71, -58.02 -84.26, 100.6 -93.09, 48.78 282.6, 95.84 -80.87, -18.04 in-out in 8.784 Saltbr-out 3.664 HRD-out -108.84, 109.5 -77.51, -36.15 out-in-in SNCoii in-in ActLoopNT-in 3.488 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.54, -43.28 APE9-dihe-na -77.94, 146.2 APE8-dihe-in -56.64, 131.6 APE8-rot-in 308.37 APE67-dihe-in -104.38, -21.7 -62.92, -1.65 APE12-dist-in 12.856 APE11-dist-in 12.642 APE10-dist-in 6.914 APE9-dist-in 4.414 None None None EM 3.9 999.0 999.0 8 346 298 1 0 0 0 [[12, 295]] 1.0 7egc CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
7ENA8 13 311 346.0 No_ligand No_ligand Inactive DFGin 6.159 16.961 None -137.92, -69.17 -57.97, 126.4 -129.18, 16.9 254.87, 60.55 -63.02, -41.24 in-out in 9.405 Saltbr-out 5.529 HRD-out -89.6, 97.27 -59.31, -35.69 out-in-in SNCoii in-in ActLoopNT-in 3.123 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.33, -53.74 APE9-dihe-na -65.5, 156.02 APE8-dihe-in -61.05, 144.25 APE8-rot-in 317.22 APE67-dihe-in -60.5, -45.43 -56.27, -38.88 APE12-dist-in 12.627 APE11-dist-in 12.461 APE10-dist-in 6.912 APE9-dist-in 4.95 None None None EM 4.07 999.0 999.0 8 346 299 1 0 0 0 [[12, 295]] 1.0 7ena CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8BYQ8 13 310 346.0 No_ligand No_ligand Inactive DFGin 6.883 15.26 None -127.43, -46.68 -74.13, 79.99 -89.7, 31.43 293.88, 102.94 -76.34, -19.76 in-in in 8.544 Saltbr-in 2.939 HRD-out -110.14, 88.9 -51.71, -64.8 in-in-out SNCiio in-out ActLoopNT-in 2.811 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooi APE10-dihe-na -112.6, -33.42 APE9-dihe-na -72.79, 145.26 APE8-dihe-in -52.67, 130.55 APE8-rot-in 304.24 APE67-dihe-in -67.92, -7.8 -46.32, -42.89 APE12-dist-out 14.299 APE11-dist-out 14.014 APE10-dist-out 8.127 APE9-dist-in 4.887 None None None EM 4.1 999.0 999.0 8 346 298 1 0 0 0 [[12, 295]] 1.0 8byq CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8GXQHI 13 311 346.0 No_ligand No_ligand Inactive DFGin 6.16 16.96 None -137.77, -69.32 -57.85, 126.33 -129.21, 16.87 254.81, 60.64 -63.11, -41.19 in-na in 9.405 Saltbr-na 999.0 HRD-out -89.54, 97.16 -59.39, -35.6 na-in-out SNCaio in-out ActLoopNT-in 3.123 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -64.78, -39.13 APE9-dihe-na -69.49, 155.25 APE8-dihe-in -63.89, 150.19 APE8-rot-out 50.1 APE67-dihe-in -62.44, -39.29 -58.88, -44.43 APE12-dist-in 12.627 APE11-dist-in 12.532 APE10-dist-in 6.528 APE9-dist-in 5.098 K41A None None EM 5.04 999.0 999.0 HI 346 299 1 0 0 0 [[12, 295]] 1.0 8gxq CMGC_CDK7_HUMAN CMGC 5.8e-77 266.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8GXSHI 13 311 346.0 No_ligand No_ligand Inactive DFGin 6.16 16.961 None -137.74, -69.29 -57.91, 126.39 -129.28, 17.01 254.83, 60.43 -63.16, -41.26 in-na in 9.405 Saltbr-na 999.0 HRD-out -89.55, 97.29 -59.32, -35.73 na-in-in SNCaii in-in ActLoopNT-in 3.124 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.36, -53.7 APE9-dihe-na -65.65, 155.95 APE8-dihe-in -61.02, 136.47 APE8-rot-in 317.37 APE67-dihe-in -60.45, -41.25 -41.53, -50.25 APE12-dist-in 12.626 APE11-dist-in 12.461 APE10-dist-in 6.913 APE9-dist-in 4.949 K41A None None EM 4.16 999.0 999.0 HI 346 299 1 0 0 0 [[12, 295]] 1.0 8gxs CMGC_CDK7_HUMAN CMGC 5.8e-77 266.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
6XD3J 10 312 346.0 V0G:401 Type1 Inactive DFGin 6.449 15.569 None -83.3, -65.23 -79.84, 107.47 -100.97, 25.31 275.83, 77.7 -59.79, -36.45 in-out in 7.737 Saltbr-out 3.935 HRD-out -83.2, 82.34 -68.79, 3.46 out-in-out SNCoio in-out ActLoopNT-in 2.833 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -91.06, 77.29 APE9-dihe-na -174.12, 154.78 APE8-dihe-in -58.68, 146.66 APE8-rot-out 59.06 APE67-dihe-in -62.31, -31.09 -65.15, -41.16 APE12-dist-in 13.619 APE11-dist-in 11.525 APE10-dist-in 6.127 APE9-dist-in 3.628 None SEP164 SEP164 EM 3.3 999.0 999.0 J 349 298 5 0 0 0 [[12, 295]] 1.0 6xd3 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8PYRA 46 311 346.0 No_ligand No_ligand Inactive None 6.543 999.0 None -122.94, -68.2 -80.73, 102.32 -98.18, 22.66 281.33, 69.82 -69.91, -16.7 none-none none 999.0 Saltbr-none 999.0 HRD-in -77.35, -47.6 64.82, 19.19 none-in-in SNCnii in-in ActLoopNT-in 2.83 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.11, 167.33 APE9-dihe-na 68.76, 128.67 APE8-dihe-in -52.64, 137.07 APE8-rot-in 303.34 APE67-dihe-in -60.29, -22.26 -49.6, -45.66 APE12-dist-in 12.87 APE11-dist-in 10.86 APE10-dist-in 6.358 APE9-dist-in 3.203 None SEP164,TPO170 SEP164,TPO170 XRAY 2.15 0.223 0.241 A 346 266 34 0 0 0 [[12, 295]] 1.0 8pyr CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
8PYRE 51 310 346.0 No_ligand No_ligand Inactive None 6.512 999.0 None -129.77, -168.82 32.02, 94.76 -100.83, 24.77 279.75, 68.97 -67.87, -15.59 none-none none 999.0 Saltbr-none 999.0 HRD-in -77.49, -47.54 64.99, 19.99 none-in-in SNCnii in-in ActLoopNT-in 2.816 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.08, 166.13 APE9-dihe-na 67.89, 131.66 APE8-dihe-in -53.3, 135.79 APE8-rot-in 302.92 APE67-dihe-in -59.26, -22.23 -50.11, -44.65 APE12-dist-in 12.871 APE11-dist-in 10.752 APE10-dist-in 6.362 APE9-dist-in 3.148 None SEP164,TPO170 SEP164,TPO170 XRAY 2.15 0.223 0.241 E 346 260 39 0 0 0 [[12, 295]] 1.0 8pyr CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
9HIXJ 10 312 346.0 V0G:60401 Type1 None DFGin 6.886 15.384 BLAminus -132.71, -170.75 57.98, 64.3 -89.34, 21.26 284.18, 75.08 -68.9, -17.68 in-in in 8.195 Saltbr-in 3.223 HRD-in -66.5, -50.94 64.89, 9.03 in-in-none SNCiin in-none ActLoopNT-in 2.845 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -133.15, 168.02 APE9-dihe-na 68.67, 143.0 APE8-dihe-in -61.15, 147.72 APE8-rot-in 301.8 APE67-dihe-in -61.71, -29.08 -59.06, -43.61 APE12-dist-none 999.0 APE11-dist-in 11.348 APE10-dist-in 6.986 APE9-dist-in 3.305 D97N None None EM 2.6 999.0 999.0 J 349 284 19 0 0 6 [[12, 295]] 1.0 9hix CMGC_CDK7_HUMAN CMGC 1.8e-78 271.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7

CMGC_CDK7 (Cyclin-dependent kinase 7)

Total number of chains: 70
Active chains: 19
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 41 58.6% AF-P50613-K1A
DFGin None 18 25.7% 6Z4XB
DFGin ABAminus 7 10.0% 6Z3UB
None None 2 2.9% 8PYRA
DFGin BLAplus 1 1.4% 8P4ZA
DFGin BLBplus 1 1.4% 8P4ZB

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
G0SFC6_CHATD 6Z3UB G0SFC6 78 399 437.0 No_ligand No_ligand Inactive DFGin 6.187 16.144 ABAminus -120.58, -60.22 -80.28, 113.77 -113.12, 20.84 275.04, 80.6 -66.33, -12.84 in-in in 8.792 Saltbr-in 3.156 HRD-in -82.77, -49.81 62.97, 30.61 in-in-in SNCiii in-in ActLoopNT-in 2.757 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.31, 165.38 APE9-dihe-na 68.63, 129.8 APE8-dihe-in -54.79, 144.38 APE8-rot-in 303.95 APE67-dihe-in -56.42, -20.69 -49.53, -53.13 APE12-dist-in 13.146 APE11-dist-in 10.358 APE10-dist-in 6.291 APE9-dist-in 3.34 None None None XRAY 2.6 0.205 0.249 B 437 322 0 0 0 0 [[92, 383]] 1.0 6z3u Chaetomium thermophilum CMGC_CDK7_CHATD CMGC 1.5e-61 214.7 2 300 299 237 238 239 241 243 122 141 145 217 219 218 220 278 265 260 259 258 257 256 255 254 173 Protein kinase domain-containing protein
G0SFC6_CHATD 6Z3UE G0SFC6 77 399 437.0 No_ligand No_ligand Inactive DFGin 6.024 16.096 ABAminus -122.7, -59.25 -78.93, 114.6 -113.2, 21.06 276.92, 82.81 -66.47, -13.07 in-in in 8.698 Saltbr-in 3.157 HRD-in -80.95, -48.31 63.97, 27.92 in-in-in SNCiii in-in ActLoopNT-in 2.903 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.57, 167.34 APE9-dihe-na 69.18, 133.08 APE8-dihe-in -54.75, 142.65 APE8-rot-in 303.96 APE67-dihe-in -57.02, -21.82 -50.55, -52.54 APE12-dist-in 13.015 APE11-dist-in 10.308 APE10-dist-in 6.214 APE9-dist-in 3.44 None None None XRAY 2.6 0.205 0.249 E 437 323 0 0 0 0 [[92, 383]] 1.0 6z3u Chaetomium thermophilum CMGC_CDK7_CHATD CMGC 1.5e-61 214.7 2 300 299 237 238 239 241 243 122 141 145 217 219 218 220 278 265 260 259 258 257 256 255 254 173 Protein kinase domain-containing protein
G0SFC6_CHATD 6Z4XB G0SFC6 78 399 437.0 AGS:501 ATPlike Inactive DFGin 6.066 15.963 None -120.32, -64.48 -72.18, 111.3 -111.88, 18.28 274.56, 83.55 -65.42, -11.7 in-out in 8.901 Saltbr-out 3.719 HRD-in -82.6, -50.25 63.05, 25.15 out-in-in SNCoii in-in ActLoopNT-in 2.748 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.45, 163.36 APE9-dihe-na 70.87, 128.98 APE8-dihe-in -54.32, 144.95 APE8-rot-in 303.7 APE67-dihe-in -58.5, -22.2 -48.9, -49.43 APE12-dist-in 13.121 APE11-dist-in 10.328 APE10-dist-in 6.158 APE9-dist-in 3.043 None None None XRAY 2.98 0.205 0.246 B 437 322 0 0 0 0 [[92, 383]] 1.0 6z4x Chaetomium thermophilum CMGC_CDK7_CHATD CMGC 1.5e-61 214.7 2 300 299 237 238 239 241 243 122 141 145 217 219 218 220 278 265 260 259 258 257 256 255 254 173 Protein kinase domain-containing protein
G0SFC6_CHATD 6Z4XE G0SFC6 77 399 437.0 AGS:501 ATPlike Inactive DFGin 6.045 15.891 None -120.83, -65.38 -72.38, 111.16 -111.28, 19.39 275.38, 85.23 -65.84, -12.59 in-out in 8.902 Saltbr-out 3.667 HRD-in -79.74, -48.62 65.81, 23.05 out-in-in SNCoii in-in ActLoopNT-in 2.907 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.65, 161.76 APE9-dihe-na 74.19, 130.39 APE8-dihe-in -54.74, 142.95 APE8-rot-in 302.5 APE67-dihe-in -58.43, -23.34 -50.65, -48.02 APE12-dist-in 13.252 APE11-dist-in 10.423 APE10-dist-in 6.147 APE9-dist-in 3.159 None None None XRAY 2.98 0.205 0.246 E 437 323 0 0 0 0 [[92, 383]] 1.0 6z4x Chaetomium thermophilum CMGC_CDK7_CHATD CMGC 1.5e-61 214.7 2 300 299 237 238 239 241 243 122 141 145 217 219 218 220 278 265 260 259 258 257 256 255 254 173 Protein kinase domain-containing protein
CDK7_HUMAN 9HIYJ P50613 10 310 346.0 AGS:60401 ATPlike Active DFGin 6.727 15.718 BLAminus -144.39, -174.23 58.17, 64.72 -87.83, 23.91 281.92, 72.77 -77.85, -11.75 in-in in 8.542 Saltbr-in 3.5 HRD-in -67.31, -50.64 65.74, 8.28 in-in-in SNCiii in-in ActLoopNT-in 2.733 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.25, 164.09 APE9-dihe-na 67.64, 142.62 APE8-dihe-in -59.57, 146.87 APE8-rot-in 317.63 APE67-dihe-in -64.96, -18.05 -61.86, -38.17 APE12-dist-in 13.579 APE11-dist-in 11.322 APE10-dist-in 6.933 APE9-dist-in 3.352 D97N None None EM 2.3 999.0 999.0 J 349 287 14 0 0 3 [[12, 295]] 1.0 9hiy Homo sapiens CMGC_CDK7_HUMAN CMGC 1.8e-78 271.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN AF-P50613-K1A P50613 4 303 346.0 No_ligand No_ligand Active DFGin 6.947 14.651 BLAminus -139.37, 174.94 56.44, 65.77 -76.49, 16.79 285.4, 76.38 -56.51, -40.53 in-in in 9.069 Saltbr-in 2.781 HRD-in -73.36, -47.54 60.11, 19.26 in-in-in SNCiii in-in ActLoopNT-in 2.926 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.44, 167.69 APE9-dihe-na 62.53, 130.0 APE8-dihe-in -57.01, 134.36 APE8-rot-in 299.11 APE67-dihe-in -63.68, -24.26 -47.72, -44.22 APE12-dist-in 12.878 APE11-dist-in 10.698 APE10-dist-in 6.323 APE9-dist-in 3.385 None None None AF2 -1.0 1.0 1.0 A 301 301 0 0 0 0 [[12, 295]] 1.0 AF-P50613-K1 Homo sapiens CMGC_CDK7_HUMAN CMGC 9.5e-79 272.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN AF-P50613-K3A P50613 4 303 346.0 No_ligand No_ligand Active DFGin 6.865 14.636 BLAminus -137.06, 174.38 58.01, 69.42 -79.21, 16.29 289.72, 83.63 -59.38, -30.4 in-in in 9.199 Saltbr-in 2.9 HRD-in -77.13, -48.76 60.55, 22.8 in-in-in SNCiii in-in ActLoopNT-in 2.847 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.28, 162.28 APE9-dihe-na 61.56, 143.42 APE8-dihe-in -57.15, 134.76 APE8-rot-in 295.02 APE67-dihe-in -64.26, -20.94 -45.41, -43.91 APE12-dist-in 12.56 APE11-dist-in 10.514 APE10-dist-in 6.324 APE9-dist-in 3.674 None None None AF2 -1.0 1.0 1.0 A 301 301 0 0 0 0 [[12, 295]] 1.0 AF-P50613-K3 Homo sapiens CMGC_CDK7_HUMAN CMGC 9.5e-79 272.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8ORMJ P50613 10 312 346.0 V0G:60401 Type1 Active DFGin 6.785 15.213 BLAminus -141.24, -179.07 57.58, 66.36 -85.75, 20.07 280.87, 76.67 -67.32, -17.72 in-in in 7.944 Saltbr-in 2.798 HRD-in -68.87, -49.12 65.49, 10.0 in-in-in SNCiii in-in ActLoopNT-in 2.723 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -64.18, 162.48 APE9-dihe-na 68.43, 133.67 APE8-dihe-in -60.65, 148.97 APE8-rot-in 313.74 APE67-dihe-in -63.64, -17.24 -60.73, -41.91 APE12-dist-in 13.184 APE11-dist-in 10.147 APE10-dist-in 6.535 APE9-dist-in 3.139 None None None EM 1.9 999.0 999.0 J 349 288 15 0 0 0 [[12, 295]] 1.0 8orm Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8P6WJ P50613 10 310 346.0 X2H:60401 Type1 Active DFGin 6.842 15.16 BLAminus -137.23, -179.69 59.15, 67.62 -86.16, 22.96 283.72, 72.83 -68.87, -18.76 in-in in 7.993 Saltbr-in 2.6 HRD-in -71.82, -52.01 68.31, 9.83 in-in-in SNCiii in-in ActLoopNT-in 2.828 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -70.04, 165.31 APE9-dihe-na 68.58, 140.54 APE8-dihe-in -58.26, 142.95 APE8-rot-in 296.58 APE67-dihe-in -61.43, -27.53 -59.59, -38.5 APE12-dist-in 13.237 APE11-dist-in 10.523 APE10-dist-in 6.652 APE9-dist-in 3.261 None None None EM 1.9 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p6w Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8P6XJ P50613 10 310 346.0 NS9:60401 Type1 Active DFGin 6.851 14.813 BLAminus -135.05, 178.22 58.13, 67.79 -85.98, 19.26 285.9, 76.96 -64.86, -16.71 in-in in 7.825 Saltbr-in 2.914 HRD-in -71.27, -49.07 64.89, 10.59 in-in-in SNCiii in-in ActLoopNT-in 2.72 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.37, 162.4 APE9-dihe-na 67.39, 142.34 APE8-dihe-in -59.13, 147.28 APE8-rot-in 319.82 APE67-dihe-in -62.51, -24.45 -59.1, -40.68 APE12-dist-in 13.227 APE11-dist-in 10.943 APE10-dist-in 6.835 APE9-dist-in 3.218 None None None EM 1.9 999.0 999.0 J 349 287 14 0 0 0 [[12, 295]] 1.0 8p6x Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8P6ZJ P50613 10 310 346.0 X4L:60401 Type1 Active DFGin 6.845 15.162 BLAminus -137.28, -176.81 56.96, 64.2 -83.99, 20.83 280.3, 71.49 -69.63, -17.27 in-in in 7.953 Saltbr-in 2.775 HRD-in -65.96, -49.05 64.06, 7.7 in-in-in SNCiii in-in ActLoopNT-in 2.704 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.3, 163.0 APE9-dihe-na 69.25, 136.79 APE8-dihe-in -58.74, 147.61 APE8-rot-in 317.24 APE67-dihe-in -63.74, -16.65 -59.48, -42.34 APE12-dist-in 13.319 APE11-dist-in 10.889 APE10-dist-in 6.752 APE9-dist-in 3.26 None None None EM 2.1 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p6z Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8P70J P50613 10 310 346.0 X4Q:60401 Type1 Active DFGin 6.874 15.092 BLAminus -142.71, -177.59 56.15, 66.23 -84.04, 19.36 281.9, 75.11 -68.69, -16.49 in-in in 7.938 Saltbr-in 3.512 HRD-in -68.82, -48.77 64.26, 11.24 in-in-in SNCiii in-in ActLoopNT-in 2.595 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -66.04, 164.02 APE9-dihe-na 68.08, 131.62 APE8-dihe-in -58.96, 140.51 APE8-rot-in 280.59 APE67-dihe-in -61.53, -26.64 -53.74, -37.34 APE12-dist-in 13.015 APE11-dist-in 10.084 APE10-dist-in 6.386 APE9-dist-in 3.389 None None None EM 2.0 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p70 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8P71J P50613 10 310 346.0 X4F:60401 Type1 Active DFGin 6.832 15.304 BLAminus -139.46, 179.9 57.59, 64.02 -82.45, 17.71 282.17, 74.47 -64.72, -19.22 in-in in 8.103 Saltbr-in 2.694 HRD-in -67.33, -49.46 65.63, 5.51 in-in-in SNCiii in-in ActLoopNT-in 2.639 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.68, 168.49 APE9-dihe-na 67.33, 140.05 APE8-dihe-in -60.3, 143.93 APE8-rot-in 294.53 APE67-dihe-in -61.0, -25.19 -55.87, -41.76 APE12-dist-in 13.411 APE11-dist-in 11.192 APE10-dist-in 6.803 APE9-dist-in 3.276 None None None EM 2.0 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p71 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8P72J P50613 10 310 346.0 X2Z:60401 Type1 Active DFGin 6.81 15.179 BLAminus -130.9, -176.92 58.16, 64.29 -83.54, 19.02 283.95, 72.61 -67.67, -15.09 in-in in 7.825 Saltbr-in 3.159 HRD-in -69.91, -48.69 65.53, 7.3 in-in-in SNCiii in-in ActLoopNT-in 2.659 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.29, 167.52 APE9-dihe-na 66.45, 136.14 APE8-dihe-in -56.02, 147.06 APE8-rot-in 307.2 APE67-dihe-in -65.26, -13.33 -60.11, -40.4 APE12-dist-in 13.222 APE11-dist-in 11.182 APE10-dist-in 6.764 APE9-dist-in 3.319 None None None EM 1.9 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p72 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8P74J P50613 10 310 346.0 X3Z:60401 Type1 Active DFGin 6.861 15.35 BLAminus -126.73, -179.0 57.96, 65.75 -84.45, 17.34 284.54, 71.79 -65.15, -14.93 in-in in 8.007 Saltbr-in 3.583 HRD-in -66.93, -50.55 65.6, 8.65 in-in-in SNCiii in-in ActLoopNT-in 2.713 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -69.08, 167.42 APE9-dihe-na 68.9, 135.74 APE8-dihe-in -59.35, 143.48 APE8-rot-in 303.84 APE67-dihe-in -62.59, -20.42 -57.54, -39.85 APE12-dist-in 13.339 APE11-dist-in 10.73 APE10-dist-in 6.635 APE9-dist-in 3.308 None None None EM 2.2 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p74 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8P75J P50613 10 310 346.0 X3Z:60401 Type1 Active DFGin 6.779 15.023 BLAminus -128.38, -178.74 57.34, 65.53 -84.63, 21.61 285.86, 73.49 -66.63, -20.58 in-in in 8.05 Saltbr-in 3.528 HRD-in -67.27, -50.27 64.07, 11.38 in-in-in SNCiii in-in ActLoopNT-in 2.689 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -63.45, 162.65 APE9-dihe-na 66.45, 130.41 APE8-dihe-in -60.91, 145.09 APE8-rot-in 289.58 APE67-dihe-in -61.8, -23.53 -52.32, -42.29 APE12-dist-in 12.784 APE11-dist-in 10.01 APE10-dist-in 6.403 APE9-dist-in 3.259 None None None EM 2.0 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p75 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8P76J P50613 10 310 346.0 X1W:60401 Type1 Active DFGin 6.683 15.24 BLAminus -132.14, -176.12 57.5, 64.48 -83.86, 23.79 282.12, 75.12 -69.62, -20.7 in-in in 8.284 Saltbr-in 2.994 HRD-in -66.77, -49.39 65.46, 6.65 in-in-in SNCiii in-in ActLoopNT-in 2.769 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.7, 165.52 APE9-dihe-na 69.09, 136.44 APE8-dihe-in -57.06, 139.28 APE8-rot-in 298.41 APE67-dihe-in -63.31, -19.63 -54.89, -39.03 APE12-dist-in 13.406 APE11-dist-in 11.067 APE10-dist-in 6.623 APE9-dist-in 3.228 None None None EM 2.0 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p76 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8P78J P50613 10 310 346.0 1QK:60401 Type1 Active DFGin 6.793 15.129 BLAminus -125.5, -177.03 58.99, 68.9 -87.31, 18.63 284.93, 69.97 -66.72, -11.37 in-in in 7.895 Saltbr-in 3.121 HRD-in -73.67, -52.36 67.02, 10.71 in-in-in SNCiii in-in ActLoopNT-in 2.905 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.06, 163.93 APE9-dihe-na 68.47, 139.58 APE8-dihe-in -57.78, 143.69 APE8-rot-in 300.23 APE67-dihe-in -60.36, -28.84 -57.18, -42.92 APE12-dist-in 13.384 APE11-dist-in 11.166 APE10-dist-in 6.835 APE9-dist-in 3.247 None None None EM 1.9 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p78 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8PLZJ P50613 10 310 346.0 ZQ6:60401 Type1 Active DFGin 6.801 15.115 BLAminus -136.55, 179.3 59.71, 67.62 -86.75, 25.05 283.25, 72.9 -71.18, -16.84 in-in in 7.871 Saltbr-in 2.737 HRD-in -68.72, -50.76 66.06, 11.17 in-in-in SNCiii in-in ActLoopNT-in 2.754 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -67.79, 164.71 APE9-dihe-na 69.95, 130.48 APE8-dihe-in -55.57, 142.92 APE8-rot-in 302.79 APE67-dihe-in -63.23, -18.36 -51.64, -46.88 APE12-dist-in 13.166 APE11-dist-in 11.098 APE10-dist-in 6.613 APE9-dist-in 3.401 None None None EM 1.9 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8plz Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8S0RJ P50613 10 312 346.0 A1H46:60401 Type1 Active DFGin 6.968 15.08 BLAminus -144.73, 176.22 56.72, 75.17 -85.01, 0.75 274.16, 82.98 -56.16, -16.18 in-in in 7.998 Saltbr-in 3.129 HRD-in -69.19, -40.44 59.81, 4.35 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -54.8, 150.59 APE9-dihe-na 54.66, 139.98 APE8-dihe-in -61.46, 112.88 APE8-rot-in 300.57 APE67-dihe-in -61.63, -25.36 -29.17, -41.93 APE12-dist-in 12.445 APE11-dist-in 10.691 APE10-dist-in 6.798 APE9-dist-in 3.446 None None None EM 2.4 999.0 999.0 J 349 298 5 0 0 0 [[12, 295]] 1.0 8s0r Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8S0TJ P50613 10 310 346.0 YNK:401 Type1 Active DFGin 7.036 15.153 BLAminus -155.14, 160.15 71.15, 63.8 -77.32, 14.33 280.99, 80.55 -67.17, -20.96 in-in in 7.547 Saltbr-in 3.069 HRD-in -68.72, -39.05 53.9, 20.09 in-in-in SNCiii in-in ActLoopNT-in 2.75 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -77.18, 165.14 APE9-dihe-na 66.79, 123.95 APE8-dihe-in -58.64, 137.09 APE8-rot-in 295.11 APE67-dihe-in -64.73, -14.43 -51.73, -38.67 APE12-dist-in 13.283 APE11-dist-in 10.31 APE10-dist-in 6.541 APE9-dist-in 3.475 None None None EM 2.3 999.0 999.0 J 349 291 10 0 0 4 [[12, 295]] 1.0 8s0t Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 7B5OJ P50613 10 311 346.0 I74:401 Type1 Active DFGin 6.72 14.798 BLAminus -137.92, -176.06 57.22, 65.94 -88.49, 25.05 285.22, 78.36 -71.06, -17.84 in-in in 8.0 Saltbr-in 3.37 HRD-in -61.91, -52.8 71.0, 10.09 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.65, -14.02 APE9-dihe-na -115.61, 138.37 APE8-dihe-in -48.22, 125.52 APE8-rot-in 295.73 APE67-dihe-in -68.0, -19.41 -43.31, -41.08 APE12-dist-in 12.958 APE11-dist-in 11.205 APE10-dist-in 6.663 APE9-dist-in 3.882 None None None EM 2.5 999.0 999.0 J 391 297 5 0 0 0 [[12, 295]] 1.0 7b5o Homo sapiens CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 7B5QJ P50613 10 311 346.0 I74:401 Type1 Active DFGin 6.836 14.899 BLAminus -147.46, 168.74 68.04, 74.93 -88.01, 20.02 281.19, 87.5 -69.68, -22.04 in-in in 7.944 Saltbr-in 3.037 HRD-in -66.27, -47.47 66.27, 29.92 in-in-in SNCiii in-in ActLoopNT-in 2.827 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.41, 51.31 APE9-dihe-na -157.4, 148.85 APE8-dihe-in -54.71, 127.13 APE8-rot-in 301.04 APE67-dihe-in -66.36, -17.91 -39.91, -44.29 APE12-dist-in 12.843 APE11-dist-in 10.813 APE10-dist-in 6.336 APE9-dist-in 4.073 None None None EM 2.5 999.0 999.0 J 391 297 5 0 0 0 [[12, 295]] 1.0 7b5q Homo sapiens CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 6XBZJ P50613 10 312 346.0 AGS:402 ATPlike Inactive DFGin 6.575 15.403 ABAminus -82.2, -66.45 -124.23, 139.62 -119.21, 25.52 290.81, 70.1 -71.19, -16.45 in-out in 8.0 Saltbr-out 4.8 HRD-out -77.12, 93.04 -84.92, 20.14 out-in-in SNCoii in-in ActLoopNT-in 2.804 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -98.95, 83.93 APE9-dihe-na -171.97, 152.98 APE8-dihe-in -55.47, 134.49 APE8-rot-in 286.18 APE67-dihe-in -62.05, -27.13 -54.66, -43.29 APE12-dist-in 13.356 APE11-dist-in 11.035 APE10-dist-in 6.035 APE9-dist-in 3.343 None SEP164 SEP164 EM 2.8 999.0 999.0 J 391 298 5 0 0 0 [[12, 295]] 1.0 6xbz Homo sapiens CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 7EGB8 P50613 10 312 346.0 No_ligand No_ligand Inactive DFGin 6.574 15.403 ABAminus -82.12, -66.54 -124.17, 139.82 -119.41, 25.53 290.76, 70.02 -71.23, -16.48 in-out in 7.999 Saltbr-out 4.8 HRD-out -77.22, 93.3 -85.15, 20.16 out-in-in SNCoii in-in ActLoopNT-in 2.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -98.86, 83.92 APE9-dihe-na -172.07, 152.96 APE8-dihe-in -55.37, 134.47 APE8-rot-in 286.2 APE67-dihe-in -61.89, -27.4 -54.68, -43.45 APE12-dist-in 13.355 APE11-dist-in 11.034 APE10-dist-in 6.034 APE9-dist-in 3.342 None None None EM 3.3 999.0 999.0 8 346 298 5 0 0 0 [[12, 295]] 1.0 7egb Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 7ENC8 P50613 13 311 346.0 No_ligand No_ligand Inactive DFGin 6.514 16.247 ABAminus -64.35, -41.45 -112.45, 122.65 -107.33, 5.04 259.59, 77.14 -63.64, -39.66 in-out in 8.879 Saltbr-out 6.538 HRD-out -92.81, 108.56 -64.77, -42.72 out-in-in SNCoii in-in ActLoopNT-in 3.0 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -64.87, -37.92 APE9-dihe-na -64.09, 148.4 APE8-dihe-in -61.22, 145.32 APE8-rot-in 317.7 APE67-dihe-in -62.36, -38.05 -60.97, -38.88 APE12-dist-in 12.482 APE11-dist-in 11.676 APE10-dist-in 5.853 APE9-dist-in 4.072 None None None EM 4.13 999.0 999.0 8 346 299 1 0 0 0 [[12, 295]] 1.0 7enc Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 7LBME P50613 10 312 346.0 No_ligand No_ligand Inactive DFGin 6.576 15.404 ABAminus -82.19, -66.37 -124.2, 139.55 -119.24, 25.56 290.85, 70.19 -71.05, -16.66 in-out in 8.002 Saltbr-out 4.8 HRD-out -77.15, 93.07 -84.86, 20.11 out-in-in SNCoii in-in ActLoopNT-in 2.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -99.1, 83.97 APE9-dihe-na -172.08, 152.92 APE8-dihe-in -55.28, 134.54 APE8-rot-in 286.18 APE67-dihe-in -61.92, -27.24 -54.87, -43.23 APE12-dist-in 13.358 APE11-dist-in 11.034 APE10-dist-in 6.038 APE9-dist-in 3.34 None None None EM 4.8 999.0 999.0 e 346 298 5 0 0 0 [[12, 295]] 1.0 7lbm Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 7NVR8 P50613 10 312 346.0 No_ligand No_ligand Inactive DFGin 6.575 15.404 ABAminus -82.15, -66.43 -124.26, 139.65 -119.26, 25.3 290.79, 70.05 -71.01, -16.51 in-out in 8.0 Saltbr-out 4.8 HRD-out -77.07, 93.05 -85.02, 20.22 out-in-in SNCoii in-in ActLoopNT-in 2.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -99.0, 83.91 APE9-dihe-na -171.85, 153.06 APE8-dihe-in -55.52, 134.56 APE8-rot-in 286.15 APE67-dihe-in -61.94, -27.21 -54.65, -43.34 APE12-dist-in 13.355 APE11-dist-in 11.032 APE10-dist-in 6.034 APE9-dist-in 3.342 None None None EM 4.5 999.0 999.0 8 346 298 5 0 0 0 [[12, 295]] 1.0 7nvr Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8R99A P50613 10 311 346.0 ANP:401 ATPlike Inactive DFGin 6.921 15.074 BLAminus -136.18, 178.53 62.42, 80.05 -92.8, 32.41 285.07, 70.02 -64.17, -34.45 in-out in 9.457 Saltbr-out 5.606 HRD-in -70.53, -54.5 69.94, 6.7 out-in-out SNCoio in-out ActLoopNT-in 2.711 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -115.64, 148.75 APE9-dihe-na -60.57, 161.29 APE8-dihe-in -48.68, 142.11 APE8-rot-out 161.53 APE67-dihe-in -67.83, -20.09 -55.43, -38.94 APE12-dist-in 10.449 APE11-dist-out 5.162 APE10-dist-out 9.448 APE9-dist-in 3.715 W132R,S164D,T170E None None XRAY 1.81 0.178 0.22 A 371 283 19 0 0 0 [[12, 295]] 1.0 8r99 Homo sapiens CMGC_CDK7_HUMAN CMGC 7.3e-78 269.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8P6YJ P50613 10 310 346.0 AGS:60401 ATPlike Inactive DFGin 6.825 15.586 BLAminus -141.03, -177.14 58.28, 66.28 -86.35, 22.83 281.11, 73.93 -65.68, -18.8 in-out in 8.43 Saltbr-out 4.94 HRD-in -69.3, -48.75 64.3, 11.38 out-in-in SNCoii in-in ActLoopNT-in 2.794 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.65, 164.79 APE9-dihe-na 67.53, 137.74 APE8-dihe-in -59.47, 143.7 APE8-rot-in 312.32 APE67-dihe-in -62.79, -23.75 -56.89, -39.97 APE12-dist-in 13.313 APE11-dist-in 11.042 APE10-dist-in 6.646 APE9-dist-in 3.274 None None None EM 1.9 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p6y Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 9I9IJ P50613 12 310 346.0 ADP:60401 ATPlike Inactive DFGin 6.598 15.148 BLAminus -154.26, -174.63 55.49, 63.23 -84.52, 21.08 280.13, 83.68 -62.16, -39.37 in-out in 8.62 Saltbr-out 4.724 HRD-in -68.87, -48.72 60.83, 9.92 out-in-out SNCoio in-out ActLoopNT-in 2.772 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -114.8, -59.65 APE9-dihe-na -71.54, 157.02 APE8-dihe-in -67.36, 161.57 APE8-rot-out 77.35 APE67-dihe-in -72.1, -35.43 -63.15, -31.03 APE12-dist-in 12.421 APE11-dist-in 11.24 APE10-dist-in 6.135 APE9-dist-in 3.716 None None None EM 3.5 999.0 999.0 J 391 294 5 0 0 0 [[12, 295]] 1.0 9i9i Homo sapiens CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 9I9JJ P50613 11 310 346.0 ADP:60401 ATPlike Inactive DFGin 7.046 15.511 BLAminus -142.62, -171.5 55.13, 63.56 -86.1, 20.41 278.63, 86.43 -73.48, -14.71 in-in in 8.475 Saltbr-in 3.262 HRD-in -63.57, -47.3 66.21, -0.54 in-in-out SNCiio in-out ActLoopNT-in 2.876 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -125.41, 160.15 APE9-dihe-na -72.91, 167.58 APE8-dihe-in -60.97, 159.12 APE8-rot-out 182.98 APE67-dihe-in -64.29, -19.96 -63.65, -26.45 APE12-dist-in 11.208 APE11-dist-out 5.341 APE10-dist-out 9.202 APE9-dist-in 4.033 None None None EM 3.1 999.0 999.0 J 391 290 10 0 0 5 [[12, 295]] 1.0 9i9j Homo sapiens CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 9I9KJ P50613 10 310 346.0 ADP:60401 ATPlike Inactive DFGin 6.867 15.16 BLAminus -144.56, -175.34 58.29, 64.88 -85.43, 20.68 280.65, 74.04 -68.51, -15.78 in-in in 8.403 Saltbr-in 3.423 HRD-in -66.35, -48.78 67.04, 4.57 in-in-out SNCiio in-out ActLoopNT-in 2.701 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -135.97, 162.75 APE9-dihe-na -69.89, 166.52 APE8-dihe-in -58.19, 147.77 APE8-rot-out 190.67 APE67-dihe-in -62.09, -25.1 -66.28, -24.83 APE12-dist-in 11.543 APE11-dist-out 5.948 APE10-dist-out 9.159 APE9-dist-in 3.891 None None None EM 2.4 999.0 999.0 J 391 301 0 0 0 0 [[12, 295]] 1.0 9i9k Homo sapiens CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 9QCVJ P50613 10 346 346.0 ANP:60401 ATPlike Inactive DFGin 6.812 15.58 BLAminus -138.8, -173.47 57.69, 63.92 -85.78, 14.86 277.56, 80.3 -62.91, -29.56 in-out in 8.304 Saltbr-out 4.707 HRD-in -68.14, -50.51 67.46, 2.9 out-in-out SNCoio in-out ActLoopNT-in 2.816 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -128.9, 162.73 APE9-dihe-na -74.02, 167.46 APE8-dihe-in -56.29, 150.3 APE8-rot-out 36.33 APE67-dihe-in -61.72, -30.52 -65.73, -24.93 APE12-dist-in 11.244 APE11-dist-out 5.34 APE10-dist-out 8.996 APE9-dist-in 3.808 None None None EM 2.5 999.0 999.0 J 391 307 0 0 0 0 [[12, 295]] 1.0 9qcv Homo sapiens CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 9SKQJ P50613 9 346 346.0 ANP:60401 ATPlike Inactive DFGin 7.089 16.079 BLAminus -134.4, -172.6 54.33, 63.76 -84.59, 21.04 273.82, 84.09 -68.06, -13.54 in-out in 8.685 Saltbr-out 3.604 HRD-in -66.63, -50.41 66.76, -1.97 out-in-out SNCoio in-out ActLoopNT-in 3.021 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -107.15, 155.19 APE9-dihe-na -64.85, 155.06 APE8-dihe-in -50.04, 149.57 APE8-rot-out 168.49 APE67-dihe-in -67.74, -34.69 -63.59, -17.75 APE12-dist-in 10.588 APE11-dist-out 5.67 APE10-dist-out 9.403 APE9-dist-in 3.987 None None None EM 3.4 999.0 999.0 J 391 306 0 0 0 0 [[12, 295]] 1.0 9skq Homo sapiens CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8R9SA P50613 8 312 346.0 PE3:401,PE3:403,YPK:404 Allosteric,Allosteric,Type1 Inactive DFGin 6.83 14.284 BLAminus -165.69, -175.97 45.67, 75.58 -92.62, 3.64 268.0, 93.26 -57.82, -22.21 in-in in 8.864 Saltbr-in 3.405 HRD-out -94.27, 75.87 -64.42, -8.36 in-in-out SNCiio in-out ActLoopNT-in 2.91 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_niii APE10-dihe-na -133.05, -48.43 APE9-dihe-na -60.09, 172.76 APE8-dihe-in -90.13, 61.97 APE8-rot-in 341.49 APE67-dihe-out -70.79, -35.04 59.18, -50.38 APE12-dist-none 999.0 APE11-dist-in 12.724 APE10-dist-in 6.865 APE9-dist-in 4.005 W132R,S164D,T170E None None XRAY 2.78 0.24 0.296 A 371 289 16 0 0 9 [[12, 295]] 1.0 8r9s Homo sapiens CMGC_CDK7_HUMAN CMGC 7.3e-78 269.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8BVW8 P50613 13 311 346.0 No_ligand No_ligand Inactive DFGin 6.66 15.538 BLAminus -152.45, -166.11 61.66, 28.62 -60.07, -16.21 290.53, 102.36 -55.52, -24.06 in-out in 9.368 Saltbr-out 4.3 HRD-out -77.44, 94.01 -60.23, -12.16 out-in-out SNCoio in-out ActLoopNT-in 2.839 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -67.48, -28.49 APE9-dihe-na -125.08, 152.92 APE8-dihe-in -46.97, 127.53 APE8-rot-in 294.27 APE67-dihe-in -67.4, -7.76 -45.35, -46.98 APE12-dist-in 13.749 APE11-dist-in 12.261 APE10-dist-out 8.432 APE9-dist-in 3.87 None None None EM 4.0 999.0 999.0 8 346 299 1 0 0 0 [[12, 295]] 1.0 8bvw Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8P79J P50613 10 310 346.0 No_ligand No_ligand Inactive DFGin 6.867 15.187 BLAminus -130.29, 173.2 63.24, 80.76 -93.9, 15.3 279.52, 73.29 -61.35, -20.82 in-in in 7.86 Saltbr-in 2.892 HRD-in -71.98, -55.93 71.02, 14.36 in-in-out SNCiio in-out ActLoopNT-in 2.8 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -74.02, 160.13 APE9-dihe-na 70.88, 124.77 APE8-dihe-in -52.58, 142.69 APE8-rot-out 173.92 APE67-dihe-in -66.31, -20.55 -52.74, -42.41 APE12-dist-in 13.195 APE11-dist-in 10.799 APE10-dist-in 6.528 APE9-dist-in 3.419 None None None EM 1.7 0.417 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p79 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 9QCXJ P50613 9 346 346.0 No_ligand No_ligand Inactive DFGin 6.696 16.026 BLAminus -131.02, -177.03 59.81, 66.92 -86.78, 26.87 276.81, 73.59 -75.67, -10.97 in-out in 8.793 Saltbr-out 3.971 HRD-in -71.21, -46.31 66.3, 0.75 out-in-out SNCoio in-out ActLoopNT-in 2.753 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -103.75, 161.28 APE9-dihe-na -68.95, 168.1 APE8-dihe-in -56.3, 142.34 APE8-rot-out 173.25 APE67-dihe-in -65.83, -25.32 -64.61, -15.36 APE12-dist-in 10.486 APE11-dist-out 5.568 APE10-dist-out 9.089 APE9-dist-in 3.86 None None None EM 2.6 999.0 999.0 J 391 309 0 0 0 0 [[12, 295]] 1.0 9qcx Homo sapiens CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8R9AA P50613 10 311 346.0 I74:402 Type1 Inactive DFGin 6.943 14.473 BLAminus -142.15, 174.78 52.62, 81.62 -93.9, 33.78 285.76, 70.72 -69.96, -22.58 in-in in 9.259 Saltbr-in 3.38 HRD-in -71.93, -53.08 66.56, 13.4 in-in-out SNCiio in-out ActLoopNT-in 2.909 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -140.21, 140.61 APE9-dihe-na -58.82, 163.62 APE8-dihe-in -59.71, 143.88 APE8-rot-out 11.83 APE67-dihe-in -59.39, -21.26 -63.14, -34.89 APE12-dist-in 10.527 APE11-dist-out 5.215 APE10-dist-out 9.279 APE9-dist-in 3.808 W132R,S164D,T170E None None XRAY 1.71 0.224 0.294 A 371 285 17 0 0 0 [[12, 295]] 1.0 8r9a Homo sapiens CMGC_CDK7_HUMAN CMGC 7.3e-78 269.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8R9OA P50613 10 312 346.0 YN3:401 Type1 Inactive DFGin 7.01 15.105 BLAminus -129.64, 158.52 74.99, 81.61 -97.15, 34.08 294.95, 72.01 -80.74, -26.65 in-in in 9.621 Saltbr-in 3.468 HRD-in -72.69, -50.65 63.96, 5.37 in-in-out SNCiio in-out ActLoopNT-in 2.856 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 161.09 APE8-dihe-in -60.01, 150.23 APE8-rot-out 191.14 APE67-dihe-in -78.31, -17.17 -45.46, -39.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.342 W132R,S164D,T170E None None XRAY 2.22 0.258 0.344 A 371 276 27 0 0 10 [[12, 295]] 1.0 8r9o Homo sapiens CMGC_CDK7_HUMAN CMGC 7.3e-78 269.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8R9OB P50613 10 312 346.0 YN3:401 Type1 Inactive DFGin 7.041 14.997 BLAminus -138.7, 164.71 67.98, 80.71 -96.95, 34.33 295.63, 72.58 -80.3, -27.44 in-out in 9.485 Saltbr-out 4.29 HRD-in -72.39, -52.21 67.37, 12.01 out-in-out SNCoio in-out ActLoopNT-in 2.993 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooi APE10-dihe-na -159.84, 152.31 APE9-dihe-na -62.33, 160.72 APE8-dihe-in -60.74, 151.56 APE8-rot-out 191.25 APE67-dihe-in -79.05, -16.21 -45.43, -40.81 APE12-dist-none 999.0 APE11-dist-out 5.6 APE10-dist-out 8.982 APE9-dist-in 3.47 W132R,S164D,T170E None None XRAY 2.22 0.258 0.344 B 371 284 19 0 0 5 [[12, 295]] 1.0 8r9o Homo sapiens CMGC_CDK7_HUMAN CMGC 7.3e-78 269.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8R9UA P50613 10 311 346.0 YNK:401 Type1 Inactive DFGin 6.995 14.819 BLAminus -136.34, 177.25 64.26, 71.88 -94.29, 35.4 287.51, 80.17 -88.88, -17.75 in-in in 7.668 Saltbr-in 3.098 HRD-in -70.29, -39.89 54.29, 18.68 in-in-out SNCiio in-out ActLoopNT-in 2.94 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoi APE10-dihe-na 999.0, 95.99 APE9-dihe-na -33.61, 162.87 APE8-dihe-in -57.31, 147.69 APE8-rot-out 184.84 APE67-dihe-in -64.25, -23.63 -55.57, -38.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.455 APE9-dist-in 3.421 W132R,S164D,T170E None None XRAY 1.937 0.278 0.34 A 371 282 20 0 0 6 [[12, 295]] 1.0 8r9u Homo sapiens CMGC_CDK7_HUMAN CMGC 7.3e-78 269.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8R9UB P50613 10 311 346.0 YNK:401 Type1 Inactive DFGin 7.15 14.779 BLAminus -129.44, 175.01 67.08, 73.42 -94.57, 34.81 287.86, 79.6 -89.74, -17.02 in-in in 8.032 Saltbr-in 2.971 HRD-in -66.25, -52.35 71.96, 8.72 in-in-out SNCiio in-out ActLoopNT-in 2.814 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoi APE10-dihe-na 999.0, 137.47 APE9-dihe-na -49.58, 159.48 APE8-dihe-in -61.33, 140.09 APE8-rot-out 190.38 APE67-dihe-in -65.39, -24.05 -38.15, -47.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.157 APE9-dist-in 3.573 W132R,S164D,T170E None None XRAY 1.937 0.278 0.34 B 371 282 20 0 0 6 [[12, 295]] 1.0 8r9u Homo sapiens CMGC_CDK7_HUMAN CMGC 7.3e-78 269.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8P6VJ P50613 10 310 346.0 I74:60401 Type1 Inactive DFGin 6.792 15.477 BLAminus -127.02, 179.34 58.38, 68.34 -85.69, 24.62 280.05, 70.86 -67.13, -24.33 in-in in 8.222 Saltbr-in 3.215 HRD-in -67.24, -50.44 65.17, 9.5 in-in-out SNCiio in-out ActLoopNT-in 2.759 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -78.14, 165.38 APE9-dihe-na 66.68, 132.55 APE8-dihe-in -61.61, 157.58 APE8-rot-out 165.5 APE67-dihe-in -65.89, -16.75 -62.4, -42.77 APE12-dist-in 13.167 APE11-dist-in 10.687 APE10-dist-in 6.371 APE9-dist-in 3.36 None None None EM 1.9 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p6v Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8P77J P50613 10 310 346.0 I73:60401 Type1 Inactive DFGin 6.742 15.27 BLAminus -132.45, -179.7 57.66, 63.66 -82.64, 21.59 281.33, 71.76 -68.21, -17.73 in-out in 8.084 Saltbr-out 3.673 HRD-in -69.39, -48.98 63.26, 11.42 out-in-in SNCoii in-in ActLoopNT-in 2.728 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -81.35, 165.5 APE9-dihe-na 68.99, 138.58 APE8-dihe-in -57.94, 141.68 APE8-rot-in 287.47 APE67-dihe-in -62.3, -27.5 -54.83, -40.88 APE12-dist-in 13.346 APE11-dist-in 10.91 APE10-dist-in 6.69 APE9-dist-in 3.315 None None None EM 1.8 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p77 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8P7LJ P50613 10 311 346.0 WD9:401 Type1 Inactive DFGin 6.809 15.065 BLAminus -140.22, -179.03 56.2, 69.06 -86.55, 17.3 282.99, 80.61 -65.13, -17.22 in-out in 8.229 Saltbr-out 6.925 HRD-in -67.68, -49.89 66.46, 7.6 out-in-none SNCoin in-none ActLoopNT-in 2.819 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 121.08 APE9-dihe-na 72.05, 144.41 APE8-dihe-in -59.67, 147.38 APE8-rot-in 299.95 APE67-dihe-in -62.37, -38.92 -53.43, -44.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.68 APE9-dist-in 3.357 None None None EM 2.1 999.0 999.0 J 379 289 13 0 0 7 [[12, 295]] 1.0 8p7l Homo sapiens CMGC_CDK7_HUMAN CMGC 2.1e-78 271.3 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 9HJ0J P50613 12 310 346.0 I74:60401 Type1 Inactive DFGin 6.817 15.448 BLAminus -132.37, -171.58 55.11, 65.05 -85.31, 21.39 278.87, 69.2 -69.07, -20.48 in-out in 8.209 Saltbr-out 4.176 HRD-in -66.92, -50.4 64.01, 10.9 out-in-in SNCoii in-in ActLoopNT-in 2.645 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.73, 159.75 APE9-dihe-na 70.65, 131.86 APE8-dihe-in -50.1, 141.1 APE8-rot-in 304.02 APE67-dihe-in -65.42, -15.47 -59.14, -35.57 APE12-dist-in 13.42 APE11-dist-in 11.189 APE10-dist-in 6.88 APE9-dist-in 3.582 D97N None None EM 2.6 999.0 999.0 J 349 280 19 0 0 3 [[12, 295]] 1.0 9hj0 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.8e-78 271.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8P73J P50613 10 310 346.0 X50:60401,X58:60402 Type1,Type1 Inactive DFGin 6.888 15.293 BLAminus -131.62, -179.54 56.98, 66.06 -83.52, 19.3 279.49, 76.56 -67.26, -17.21 in-in in 7.97 Saltbr-in 2.852 HRD-in -73.06, -52.64 65.19, 12.23 in-in-out SNCiio in-out ActLoopNT-in 2.735 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -64.33, 163.23 APE9-dihe-na 66.68, 129.91 APE8-dihe-in -65.37, 155.44 APE8-rot-out 179.35 APE67-dihe-in -64.93, -17.64 -61.55, -43.35 APE12-dist-in 13.216 APE11-dist-in 10.776 APE10-dist-in 6.623 APE9-dist-in 3.323 None None None EM 2.0 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p73 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8P4ZA P50613 11 310 346.0 WZ8:60401 Type1 Inactive DFGin 7.012 14.218 BLAplus -138.13, 160.5 75.31, 59.87 -134.86, -7.56 51.2, 92.01 -94.58, 115.85 out-out out 14.21 Saltbr-out 13.177 HRD-in -71.48, -47.82 72.35, -9.13 out-out-out SNCooo out-out ActLoopNT-out 12.571 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -40.79 APE8-dihe-out -71.19, -16.02 APE8-rot-out 206.81 APE67-dihe-in -62.89, -27.85 -62.54, -32.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.596 None None None XRAY 2.75 0.226 0.251 A 304 272 28 0 0 13 [[12, 295]] 1.0 8p4z Homo sapiens CMGC_CDK7_HUMAN CMGC 9.8e-79 272.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8P4ZB P50613 10 310 346.0 WZ8:60401 Type1 Inactive DFGin 6.894 13.82 BLBplus -138.09, 160.99 74.49, 52.29 -133.73, 169.82 60.6, 81.42 53.64, 73.13 out-out out 13.833 Saltbr-out 12.649 HRD-in -70.02, -48.0 71.31, -8.1 out-out-out SNCooo out-out ActLoopNT-out 10.637 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -34.3 APE8-dihe-out -69.4, -20.94 APE8-rot-out 202.55 APE67-dihe-in -61.31, -27.25 -63.3, -32.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.735 None None None XRAY 2.75 0.226 0.251 B 304 277 24 0 0 12 [[12, 295]] 1.0 8p4z Homo sapiens CMGC_CDK7_HUMAN CMGC 9.8e-79 272.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 1UA2A P50613 13 311 346.0 ATP:381 ATPlike Inactive DFGin 3.838 15.074 None -72.36, 176.54 -63.29, 129.93 -58.5, 61.34 34.11, 88.78 62.95, -115.18 out-out out 13.014 Saltbr-out 13.633 HRD-out -71.94, 127.86 -111.75, 17.16 out-out-out SNCooo out-out ActLoopNT-out 10.781 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -60.17, 155.77 APE9-dihe-na -94.04, -36.01 APE8-dihe-out 80.52, 83.34 APE8-rot-in 310.15 APE67-dihe-in -70.12, 0.07 -111.89, 13.44 APE12-dist-out 21.608 APE11-dist-out 18.745 APE10-dist-out 20.457 APE9-dist-out 13.019 None TPO170 TPO170 XRAY 3.02 0.217 0.288 A 346 287 13 0 0 0 [[12, 295]] 1.0 1ua2 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 1UA2B P50613 13 311 346.0 ATP:382 ATPlike Inactive DFGin 4.075 14.483 None -83.42, -165.13 -43.25, 135.34 -79.47, 27.14 49.47, 35.58 128.26, -117.59 out-out out 13.208 Saltbr-out 11.182 HRD-out -90.35, 54.77 -58.64, -3.2 out-out-out SNCooo out-out ActLoopNT-out 10.755 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -59.37, 128.97 APE9-dihe-na -70.17, -103.62 APE8-dihe-out 114.41, 132.59 APE8-rot-out 86.06 APE67-dihe-in -64.71, -6.03 -138.86, 19.47 APE12-dist-out 21.356 APE11-dist-out 17.939 APE10-dist-out 20.116 APE9-dist-out 13.119 None TPO170 TPO170 XRAY 3.02 0.217 0.288 B 346 287 13 0 0 0 [[12, 295]] 1.0 1ua2 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 1UA2C P50613 13 311 346.0 ATP:383 ATPlike Inactive DFGin 4.377 15.832 None -69.53, 164.86 -53.4, 113.84 -55.09, 81.41 35.63, 74.81 38.07, -90.08 out-out out 14.291 Saltbr-out 13.35 HRD-out -90.81, 75.3 -67.23, 24.34 out-out-out SNCooo out-out ActLoopNT-out 10.725 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -61.3, 146.02 APE9-dihe-na -103.14, 168.98 APE8-dihe-in -149.98, 115.15 APE8-rot-in 317.59 APE67-dihe-in -70.34, -0.48 -115.08, 9.43 APE12-dist-out 21.995 APE11-dist-out 19.636 APE10-dist-out 20.119 APE9-dist-out 12.619 None TPO170 TPO170 XRAY 3.02 0.217 0.288 C 346 287 13 0 0 0 [[12, 295]] 1.0 1ua2 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 1UA2D P50613 13 311 346.0 ATP:384 ATPlike Inactive DFGin 3.971 15.482 None -66.13, 178.54 -66.01, 128.6 -62.88, 66.21 38.44, 67.87 63.18, -97.8 out-out out 13.242 Saltbr-out 13.575 HRD-out -80.45, 94.07 -71.75, -5.97 out-out-out SNCooo out-out ActLoopNT-out 10.896 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.63, 129.76 APE9-dihe-na -71.09, 152.84 APE8-dihe-in -147.91, 130.69 APE8-rot-out 68.98 APE67-dihe-in -88.14, 9.58 -128.15, 23.18 APE12-dist-out 22.145 APE11-dist-out 18.845 APE10-dist-out 20.01 APE9-dist-out 12.657 None TPO170 TPO170 XRAY 3.02 0.217 0.288 D 346 287 13 0 0 0 [[12, 295]] 1.0 1ua2 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8R9BA P50613 1 311 346.0 ANP:401 ATPlike Inactive DFGin 6.667 15.04 None -136.41, -179.13 75.36, -66.57 59.32, 16.33 291.11, 69.78 55.95, 32.69 out-out out 13.486 Saltbr-out 13.754 HRD-in -65.3, -54.78 73.94, 0.68 out-out-out SNCooo out-out ActLoopNT-out 12.55 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -74.63, 115.42 APE9-dihe-na -115.54, -2.31 APE8-dihe-out -56.05, -31.84 APE8-rot-out 157.42 APE67-dihe-in -63.34, -23.16 -66.49, -24.29 APE12-dist-out 18.002 APE11-dist-out 20.187 APE10-dist-out 16.086 APE9-dist-out 11.465 S164D,T170E None None XRAY 2.21 0.195 0.243 A 352 301 10 0 0 0 [[12, 295]] 1.0 8r9b Homo sapiens CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8R9BB P50613 3 310 346.0 ANP:402 ATPlike Inactive DFGin 6.563 15.084 None -126.22, 177.01 84.52, -73.28 65.77, 22.93 292.14, 76.04 47.33, 39.02 out-out out 13.607 Saltbr-out 11.882 HRD-in -71.08, -53.54 74.78, -6.63 out-out-out SNCooo out-out ActLoopNT-out 12.936 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -81.04, 115.32 APE9-dihe-na -115.04, 1.93 APE8-dihe-out -60.49, -32.76 APE8-rot-out 168.86 APE67-dihe-in -59.67, -24.77 -68.61, -28.01 APE12-dist-out 17.779 APE11-dist-out 20.186 APE10-dist-out 16.157 APE9-dist-out 11.416 S164D,T170E None None XRAY 2.21 0.195 0.243 B 352 298 10 0 0 0 [[12, 295]] 1.0 8r9b Homo sapiens CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8R9BC P50613 8 311 346.0 ANP:402 ATPlike Inactive DFGin 6.451 15.34 None -116.21, 176.78 77.39, -97.04 64.16, 26.01 311.61, 20.83 46.47, 58.36 out-out out 13.104 Saltbr-out 12.133 HRD-in -78.41, -55.45 77.67, -2.52 out-out-out SNCooo out-out ActLoopNT-out 12.922 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 132.76 APE9-dihe-na -87.2, -35.35 APE8-dihe-out -49.87, -35.32 APE8-rot-in 271.7 APE67-dihe-in -63.34, -21.13 -58.67, -34.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.928 APE9-dist-out 10.934 S164D,T170E None None XRAY 2.21 0.195 0.243 C 352 276 28 0 0 12 [[12, 295]] 1.0 8r9b Homo sapiens CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8R9BD P50613 9 311 346.0 ANP:402 ATPlike Inactive DFGin 5.186 15.529 None -119.23, -173.72 58.44, -119.7 56.58, 114.74 106.06, 59.9 70.5, -151.21 out-out out 13.062 Saltbr-out 12.354 HRD-in -80.52, -56.05 80.67, -8.56 out-out-out SNCooo out-out ActLoopNT-out 13.055 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -29.49 APE9-dihe-na -113.47, -32.42 APE8-dihe-out -62.11, -27.52 APE8-rot-out 75.68 APE67-dihe-in -62.12, -24.79 -50.05, -35.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.16 APE9-dist-out 11.156 S164D,T170E None None XRAY 2.21 0.195 0.243 D 352 277 26 0 0 10 [[12, 295]] 1.0 8r9b Homo sapiens CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8R9SB P50613 9 312 346.0 PE3:401,PE3:402,YPK:403 Allosteric,Allosteric,Type1 Inactive DFGin 6.661 14.137 None -136.72, -83.07 -78.7, 108.99 -96.75, 5.62 270.16, 92.75 -61.04, -22.45 in-in in 8.969 Saltbr-in 2.906 HRD-out -93.55, 75.1 -63.47, -8.59 in-in-out SNCiio in-out ActLoopNT-in 2.958 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_niii APE10-dihe-na -131.56, -46.56 APE9-dihe-na -57.97, 167.59 APE8-dihe-in -92.57, 68.94 APE8-rot-out 164.5 APE67-dihe-out -70.3, -34.85 61.12, -49.62 APE12-dist-none 999.0 APE11-dist-in 12.57 APE10-dist-in 6.741 APE9-dist-in 4.029 W132R,S164D,T170E None None XRAY 2.78 0.24 0.296 B 371 290 14 0 0 9 [[12, 295]] 1.0 8r9s Homo sapiens CMGC_CDK7_HUMAN CMGC 7.3e-78 269.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 6O9L8 P50613 13 311 346.0 No_ligand No_ligand Inactive DFGin 7.798 15.312 None -95.81, -101.98 -119.05, 160.07 -109.44, 53.11 290.95, 162.54 -72.96, -5.74 out-out out 10.662 Saltbr-out 6.489 HRD-out -97.79, 80.29 -81.32, 54.89 out-in-out SNCoio in-out ActLoopNT-in 3.413 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -106.12, -175.8 APE9-dihe-na 68.22, 148.02 APE8-dihe-in -56.94, 134.18 APE8-rot-in 300.57 APE67-dihe-in -70.23, -40.86 -66.35, -19.39 APE12-dist-in 13.709 APE11-dist-in 13.799 APE10-dist-out 8.06 APE9-dist-in 5.088 None None None EM 7.2 999.0 999.0 8 346 299 1 0 0 0 [[12, 295]] 1.0 6o9l Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 7EGC8 P50613 13 310 346.0 No_ligand No_ligand Inactive DFGin 5.879 15.554 None -116.71, -58.02 -84.26, 100.6 -93.09, 48.78 282.6, 95.84 -80.87, -18.04 in-out in 8.784 Saltbr-out 3.664 HRD-out -108.84, 109.5 -77.51, -36.15 out-in-in SNCoii in-in ActLoopNT-in 3.488 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.54, -43.28 APE9-dihe-na -77.94, 146.2 APE8-dihe-in -56.64, 131.6 APE8-rot-in 308.37 APE67-dihe-in -104.38, -21.7 -62.92, -1.65 APE12-dist-in 12.856 APE11-dist-in 12.642 APE10-dist-in 6.914 APE9-dist-in 4.414 None None None EM 3.9 999.0 999.0 8 346 298 1 0 0 0 [[12, 295]] 1.0 7egc Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 7ENA8 P50613 13 311 346.0 No_ligand No_ligand Inactive DFGin 6.159 16.961 None -137.92, -69.17 -57.97, 126.4 -129.18, 16.9 254.87, 60.55 -63.02, -41.24 in-out in 9.405 Saltbr-out 5.529 HRD-out -89.6, 97.27 -59.31, -35.69 out-in-in SNCoii in-in ActLoopNT-in 3.123 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.33, -53.74 APE9-dihe-na -65.5, 156.02 APE8-dihe-in -61.05, 144.25 APE8-rot-in 317.22 APE67-dihe-in -60.5, -45.43 -56.27, -38.88 APE12-dist-in 12.627 APE11-dist-in 12.461 APE10-dist-in 6.912 APE9-dist-in 4.95 None None None EM 4.07 999.0 999.0 8 346 299 1 0 0 0 [[12, 295]] 1.0 7ena Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8BYQ8 P50613 13 310 346.0 No_ligand No_ligand Inactive DFGin 6.883 15.26 None -127.43, -46.68 -74.13, 79.99 -89.7, 31.43 293.88, 102.94 -76.34, -19.76 in-in in 8.544 Saltbr-in 2.939 HRD-out -110.14, 88.9 -51.71, -64.8 in-in-out SNCiio in-out ActLoopNT-in 2.811 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooi APE10-dihe-na -112.6, -33.42 APE9-dihe-na -72.79, 145.26 APE8-dihe-in -52.67, 130.55 APE8-rot-in 304.24 APE67-dihe-in -67.92, -7.8 -46.32, -42.89 APE12-dist-out 14.299 APE11-dist-out 14.014 APE10-dist-out 8.127 APE9-dist-in 4.887 None None None EM 4.1 999.0 999.0 8 346 298 1 0 0 0 [[12, 295]] 1.0 8byq Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8GXQHI P50613 13 311 346.0 No_ligand No_ligand Inactive DFGin 6.16 16.96 None -137.77, -69.32 -57.85, 126.33 -129.21, 16.87 254.81, 60.64 -63.11, -41.19 in-na in 9.405 Saltbr-na 999.0 HRD-out -89.54, 97.16 -59.39, -35.6 na-in-out SNCaio in-out ActLoopNT-in 3.123 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -64.78, -39.13 APE9-dihe-na -69.49, 155.25 APE8-dihe-in -63.89, 150.19 APE8-rot-out 50.1 APE67-dihe-in -62.44, -39.29 -58.88, -44.43 APE12-dist-in 12.627 APE11-dist-in 12.532 APE10-dist-in 6.528 APE9-dist-in 5.098 K41A None None EM 5.04 999.0 999.0 HI 346 299 1 0 0 0 [[12, 295]] 1.0 8gxq Homo sapiens CMGC_CDK7_HUMAN CMGC 5.8e-77 266.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8GXSHI P50613 13 311 346.0 No_ligand No_ligand Inactive DFGin 6.16 16.961 None -137.74, -69.29 -57.91, 126.39 -129.28, 17.01 254.83, 60.43 -63.16, -41.26 in-na in 9.405 Saltbr-na 999.0 HRD-out -89.55, 97.29 -59.32, -35.73 na-in-in SNCaii in-in ActLoopNT-in 3.124 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.36, -53.7 APE9-dihe-na -65.65, 155.95 APE8-dihe-in -61.02, 136.47 APE8-rot-in 317.37 APE67-dihe-in -60.45, -41.25 -41.53, -50.25 APE12-dist-in 12.626 APE11-dist-in 12.461 APE10-dist-in 6.913 APE9-dist-in 4.949 K41A None None EM 4.16 999.0 999.0 HI 346 299 1 0 0 0 [[12, 295]] 1.0 8gxs Homo sapiens CMGC_CDK7_HUMAN CMGC 5.8e-77 266.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 6XD3J P50613 10 312 346.0 V0G:401 Type1 Inactive DFGin 6.449 15.569 None -83.3, -65.23 -79.84, 107.47 -100.97, 25.31 275.83, 77.7 -59.79, -36.45 in-out in 7.737 Saltbr-out 3.935 HRD-out -83.2, 82.34 -68.79, 3.46 out-in-out SNCoio in-out ActLoopNT-in 2.833 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -91.06, 77.29 APE9-dihe-na -174.12, 154.78 APE8-dihe-in -58.68, 146.66 APE8-rot-out 59.06 APE67-dihe-in -62.31, -31.09 -65.15, -41.16 APE12-dist-in 13.619 APE11-dist-in 11.525 APE10-dist-in 6.127 APE9-dist-in 3.628 None SEP164 SEP164 EM 3.3 999.0 999.0 J 349 298 5 0 0 0 [[12, 295]] 1.0 6xd3 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8PYRA P50613 46 311 346.0 No_ligand No_ligand Inactive None 6.543 999.0 None -122.94, -68.2 -80.73, 102.32 -98.18, 22.66 281.33, 69.82 -69.91, -16.7 none-none none 999.0 Saltbr-none 999.0 HRD-in -77.35, -47.6 64.82, 19.19 none-in-in SNCnii in-in ActLoopNT-in 2.83 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.11, 167.33 APE9-dihe-na 68.76, 128.67 APE8-dihe-in -52.64, 137.07 APE8-rot-in 303.34 APE67-dihe-in -60.29, -22.26 -49.6, -45.66 APE12-dist-in 12.87 APE11-dist-in 10.86 APE10-dist-in 6.358 APE9-dist-in 3.203 None SEP164,TPO170 SEP164,TPO170 XRAY 2.15 0.223 0.241 A 346 266 34 0 0 0 [[12, 295]] 1.0 8pyr Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 8PYRE P50613 51 310 346.0 No_ligand No_ligand Inactive None 6.512 999.0 None -129.77, -168.82 32.02, 94.76 -100.83, 24.77 279.75, 68.97 -67.87, -15.59 none-none none 999.0 Saltbr-none 999.0 HRD-in -77.49, -47.54 64.99, 19.99 none-in-in SNCnii in-in ActLoopNT-in 2.816 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.08, 166.13 APE9-dihe-na 67.89, 131.66 APE8-dihe-in -53.3, 135.79 APE8-rot-in 302.92 APE67-dihe-in -59.26, -22.23 -50.11, -44.65 APE12-dist-in 12.871 APE11-dist-in 10.752 APE10-dist-in 6.362 APE9-dist-in 3.148 None SEP164,TPO170 SEP164,TPO170 XRAY 2.15 0.223 0.241 E 346 260 39 0 0 0 [[12, 295]] 1.0 8pyr Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CDK7_HUMAN 9HIXJ P50613 10 312 346.0 V0G:60401 Type1 None DFGin 6.886 15.384 BLAminus -132.71, -170.75 57.98, 64.3 -89.34, 21.26 284.18, 75.08 -68.9, -17.68 in-in in 8.195 Saltbr-in 3.223 HRD-in -66.5, -50.94 64.89, 9.03 in-in-none SNCiin in-none ActLoopNT-in 2.845 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -133.15, 168.02 APE9-dihe-na 68.67, 143.0 APE8-dihe-in -61.15, 147.72 APE8-rot-in 301.8 APE67-dihe-in -61.71, -29.08 -59.06, -43.61 APE12-dist-none 999.0 APE11-dist-in 11.348 APE10-dist-in 6.986 APE9-dist-in 3.305 D97N None None EM 2.6 999.0 999.0 J 349 284 19 0 0 6 [[12, 295]] 1.0 9hix Homo sapiens CMGC_CDK7_HUMAN CMGC 1.8e-78 271.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7

CMGC_CDK7 (Cyclin-dependent kinase 7)

Total number of chains: 4
Active chains: 0
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 50.0% 6Z3UB
DFGin None 2 50.0% 6Z4XB

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
G0SFC6_CHATD 6Z3UB G0SFC6 78 399 437.0 No_ligand No_ligand Inactive DFGin 6.187 16.144 ABAminus -120.58, -60.22 -80.28, 113.77 -113.12, 20.84 275.04, 80.6 -66.33, -12.84 in-in in 8.792 Saltbr-in 3.156 HRD-in -82.77, -49.81 62.97, 30.61 in-in-in SNCiii in-in ActLoopNT-in 2.757 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.31, 165.38 APE9-dihe-na 68.63, 129.8 APE8-dihe-in -54.79, 144.38 APE8-rot-in 303.95 APE67-dihe-in -56.42, -20.69 -49.53, -53.13 APE12-dist-in 13.146 APE11-dist-in 10.358 APE10-dist-in 6.291 APE9-dist-in 3.34 None None None XRAY 2.6 0.205 0.249 B 437 322 0 0 0 0 [[92, 383]] 1.0 6z3u Chaetomium thermophilum CMGC_CDK7_CHATD CMGC 1.5e-61 214.7 2 300 299 237 238 239 241 243 122 141 145 217 219 218 220 278 265 260 259 258 257 256 255 254 173 Protein kinase domain-containing protein
G0SFC6_CHATD 6Z3UE G0SFC6 77 399 437.0 No_ligand No_ligand Inactive DFGin 6.024 16.096 ABAminus -122.7, -59.25 -78.93, 114.6 -113.2, 21.06 276.92, 82.81 -66.47, -13.07 in-in in 8.698 Saltbr-in 3.157 HRD-in -80.95, -48.31 63.97, 27.92 in-in-in SNCiii in-in ActLoopNT-in 2.903 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.57, 167.34 APE9-dihe-na 69.18, 133.08 APE8-dihe-in -54.75, 142.65 APE8-rot-in 303.96 APE67-dihe-in -57.02, -21.82 -50.55, -52.54 APE12-dist-in 13.015 APE11-dist-in 10.308 APE10-dist-in 6.214 APE9-dist-in 3.44 None None None XRAY 2.6 0.205 0.249 E 437 323 0 0 0 0 [[92, 383]] 1.0 6z3u Chaetomium thermophilum CMGC_CDK7_CHATD CMGC 1.5e-61 214.7 2 300 299 237 238 239 241 243 122 141 145 217 219 218 220 278 265 260 259 258 257 256 255 254 173 Protein kinase domain-containing protein
G0SFC6_CHATD 6Z4XB G0SFC6 78 399 437.0 AGS:501 ATPlike Inactive DFGin 6.066 15.963 None -120.32, -64.48 -72.18, 111.3 -111.88, 18.28 274.56, 83.55 -65.42, -11.7 in-out in 8.901 Saltbr-out 3.719 HRD-in -82.6, -50.25 63.05, 25.15 out-in-in SNCoii in-in ActLoopNT-in 2.748 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.45, 163.36 APE9-dihe-na 70.87, 128.98 APE8-dihe-in -54.32, 144.95 APE8-rot-in 303.7 APE67-dihe-in -58.5, -22.2 -48.9, -49.43 APE12-dist-in 13.121 APE11-dist-in 10.328 APE10-dist-in 6.158 APE9-dist-in 3.043 None None None XRAY 2.98 0.205 0.246 B 437 322 0 0 0 0 [[92, 383]] 1.0 6z4x Chaetomium thermophilum CMGC_CDK7_CHATD CMGC 1.5e-61 214.7 2 300 299 237 238 239 241 243 122 141 145 217 219 218 220 278 265 260 259 258 257 256 255 254 173 Protein kinase domain-containing protein
G0SFC6_CHATD 6Z4XE G0SFC6 77 399 437.0 AGS:501 ATPlike Inactive DFGin 6.045 15.891 None -120.83, -65.38 -72.38, 111.16 -111.28, 19.39 275.38, 85.23 -65.84, -12.59 in-out in 8.902 Saltbr-out 3.667 HRD-in -79.74, -48.62 65.81, 23.05 out-in-in SNCoii in-in ActLoopNT-in 2.907 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.65, 161.76 APE9-dihe-na 74.19, 130.39 APE8-dihe-in -54.74, 142.95 APE8-rot-in 302.5 APE67-dihe-in -58.43, -23.34 -50.65, -48.02 APE12-dist-in 13.252 APE11-dist-in 10.423 APE10-dist-in 6.147 APE9-dist-in 3.159 None None None XRAY 2.98 0.205 0.246 E 437 323 0 0 0 0 [[92, 383]] 1.0 6z4x Chaetomium thermophilum CMGC_CDK7_CHATD CMGC 1.5e-61 214.7 2 300 299 237 238 239 241 243 122 141 145 217 219 218 220 278 265 260 259 258 257 256 255 254 173 Protein kinase domain-containing protein