Ligand: WZ8

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 1 50.0% 8P4ZA
DFGin BLBplus 1 50.0% 8P4ZB

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
CMGC CDK7 CDK7_HUMAN 8P4ZA 2.75 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaooi APEdist_nnno WZ8 Type1 11 - 310 0 None None Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8P4ZB 2.75 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooi APEdist_nnno WZ8 Type1 10 - 310 0 None None Cyclin-dependent kinase 7

Ligand: WZ8

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 1 50.0% 8P4ZA
DFGin BLBplus 1 50.0% 8P4ZB

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC CDK7 CDK7_HUMAN 8P4ZA 2.75 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaooi APEdist_nnno WZ8 Type1 11 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK7 CDK7_HUMAN 8P4ZB 2.75 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooi APEdist_nnno WZ8 Type1 10 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens

Ligand: WZ8

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism