8S93

BTK (Tyrosine-protein kinase BTK)
Group: TYR
Uniprot: BTK_MOUSE
Organism: Mus musculus
Domain boundary: 402 - 653
Resolu: 2.1

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLBplus out-none out-out 9AJ Type1 1 - 659 0
Representative sequence - Chain A
10 20 30 40
MAAVILESIF LKRSQQkkKT SPLNFKKRLF LLTVHKLSYY
50 60 70 80
EYDFERGRRG SKKGSIDVEK ITCVETVIPE KNPPPERQIP
90 100 110 120
RRGeesseme aasaAERFPY PFQVVYDEGP LYVFSPTEEL
130 140 150 160
RKRWIHQLKN VIRYNSDLVQ KYHPCFWIDG QYLCCSQTAK
170 - - 402
NAMGCQILEN RGGGSggggs ggggsggggs GGGEIDPKDL
412 422 432 442
TFLKELGTGQ FGVVKYGKWR GQYDVAIRMI REGSMSEDEF
452 462 472 482
IEEAKVMMNL SHEKLVQLYG VCTKQRPIFI ITEYMANGCL
492 502 512 522
LNYLREMRHR FQTQQLLEMC KDVCEAMEYL ESKQFLHRDL
532 542 552 562
AARNCLVNDQ GVVKVSDFGM TRYVLDDEYT SSTGSKFPVK
572 582 592 602
WASPEVLMYS KFSSKSDIWA FGVLMWEIYS LGKMPYERFT
612 622 632 642
NSETAEHIAQ GLRLPRPHLA SERVYTIMYS CWHEKADERP
652
SFKILLSNIL DVMDEES
Lower-case residues are disordered in structure.
Mutations: Q91A,I92A,I94A,I95A,K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P
Phosphorylation: None