6TFP

BTK (Tyrosine-protein kinase BTK)
Group: TYR
Uniprot: BTK_HUMAN
Organism: Homo sapiens
Domain boundary: 402 - 653
Resolu: 2.0

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLBplus out-out out-out N6Z Type1 393 - 658 0
B Inactive DFGin BLBplus out-out out-out N6Z Type1 385 - 658 0
C Inactive DFGin BLBplus out-none out-out N6Z Type1 394 - 657 0
D Inactive DFGin BLBplus out-none out-out N6Z Type1 392 - 657 0
E Inactive DFGin BLBplus out-none out-out N6Z Type1 394 - 657 0
Representative sequence - Chain E
393 403 413 423
gpstaglgyg SWEIDPKDLT FLKELGTGQF GVVKYGKWRG
433 443 453 463
QYDVAIKMIK EGSMSEDEFI EEAKVMMNLS HEKLVQLYGV
473 483 493 503
CTKQRPIFII TEYMANGCLL NYLREMRHRF QTQQLLEMCK
513 523 533 543
DVCEAMEYLE SKQFLHRDLA ARNCLVNDQG VVKVSDFGLS
553 563 573 583
RYVLDDEYTS SVGSKFPVRW SPPEVLMYSK FSSKSDIWAF
593 603 613 623
GVLMWEIYSL GKMPYERFTN SETAEHIAQG LRLYRPHLAS
633 643 653
EKVYTIMYSC WHEKADERPT FKILLSNILD VMDEes
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: None