8GMB

BTK (Tyrosine-protein kinase BTK)
Group: TYR
Uniprot: BTK_MOUSE
Organism: Mus musculus
Domain boundary: 402 - 653
Resolu: 3.4

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLBplus out-none out-out 9AJ Type1 214 - 659 0
Representative sequence - Chain A
10 20 30 40
maavilesif lkrsqqkkkt splnfkkrlf lltvhklsyy
50 60 70 80
eydfergrrg skkgsidvek itcvetvipe knppperqip
90 100 110 120
rrgeesseme qisiierfpy pfqvvydegp lyvfspteel
130 140 150 160
rkrwihqlkn virynsdlvq kyhpcfwidg qylccsqtak
170 180 190 200
namgcqilen rngslkpgss hrktkkplpp tpeedqilkk
210 220 230 240
plppeptaap istTELKKVV ALYDYMPMNA NDLQLRKGEE
250 260 270 280
YFILEESNLP WWRARDKNGQ EGYIPSNYIT EAEDSIEMYE
290 300 310 320
WYSKHMTRSQ AEQLLKQAGa aGGFIVRDSs kagKYTVSVF
330 340 350 360
AKstGEPQGV IRHYVVCSTP QSQYYLAEKH LFSTIPELIN
370 380 390 400
YHQHNSAGLI SRLKYPVSKQ NKNPPPPPGF GYGSWEIDPK
410 420 430 440
DLTFLKELGT GQFGVVKYGK WRGQYDVAIR MIREGSMSED
450 460 470 480
EFIEEAKVMM NLSHEKLVQL YGVCTKQRPI FIITEYMANG
490 500 510 520
CLLNYLREMR HRFQTQQLLE MCKDVCEAME YLESKQFLHR
530 540 550 560
DLAARNCLVN DQGVVKVSDF GMTRYVLDDE YTSSTGSKFP
570 580 590 600
VKWASPEVLM YSKFSSKSDI WAFGVLMWEI YSLGKMPYER
610 620 630 640
FTNSETAEHI AQGLRLPRPH LASERVYTIM YSCWHEKADE
650
RPSFKILLSN ILDVMDEES
Lower-case residues are disordered in structure.
Mutations: E298A,K300A,E301A,A384P,S386P,T387P,A388P,L390F,K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P
Phosphorylation: None