TYR_JAK2-2 (Tyrosine-protein kinase JAK2)

Total number of chains: 176
Active chains: 36
Uniprot: JAK2_HUMAN
Kinase Domain Residues: 849 - 1125
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 128 72.7% 8BXHA
DFGin BLAminus 43 24.4% AF-O60674-K2A
DFGout BBAminus 3 1.7% 3UGCA
DFGin None 2 1.1% 5TQ3B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-O60674-K2A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 841 - 1132 0 None None Tyrosine-protein kinase JAK2
AF-O60674-K4A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 841 - 1132 0 None None Tyrosine-protein kinase JAK2
4YTCA 2.16 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 4HW Type1 842 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
4YTFA 1.78 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 4HZ Type1 842 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
4YTHA 2.04 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 467 Type1 842 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
4YTIA 2.52 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai VJK Type1 842 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
4JIAA 1.85 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 1K3 Type1 833 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
4E4MA 2.25 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0NH Type1 835 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
4E4MB 2.25 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0NH Type1 835 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
4E4MD 2.25 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0NH Type1 835 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
4E4ME 2.25 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0NH Type1 835 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
4GMYA 2.403 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0X5 Type1 833 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
8BX6A 1.5 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai S5I Type1 840 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
8BM2A 1.5 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai QQC Type1 840 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
8BM2B 1.5 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai QQC Type1 840 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
5WEVA 1.854 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9ZS Type1 833 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
2W1IA 2.6 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai L0I Type1 843 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
5L3AA 1.98 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 6DP Type1 841 - 1130 0 None Y1007F,Y1008F Tyrosine-protein kinase JAK2
6AAJA 2.37 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9T6 Type1 843 - 1130 0 PTR1007,PTR1008 K943A,K945A Tyrosine-protein kinase JAK2
6AAJB 2.37 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9T6 Type1 843 - 1131 0 PTR1007,PTR1008 K943A,K945A Tyrosine-protein kinase JAK2
4BBEA 1.9 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 3O4 Type1 841 - 1128 0 None D976N Tyrosine-protein kinase JAK2
4BBEB 1.9 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 3O4 Type1 841 - 1128 0 None D976N Tyrosine-protein kinase JAK2
4BBEC 1.9 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 3O4 Type1 841 - 1128 0 None D976N Tyrosine-protein kinase JAK2
4BBED 1.9 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 3O4 Type1 841 - 1128 0 None D976N Tyrosine-protein kinase JAK2
4BBFA 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai O19 Type1 841 - 1128 0 None D976N Tyrosine-protein kinase JAK2
4BBFB 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai O19 Type1 841 - 1128 0 None D976N Tyrosine-protein kinase JAK2
4BBFC 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai O19 Type1 841 - 1128 0 None D976N Tyrosine-protein kinase JAK2
4BBFD 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai O19 Type1 841 - 1128 0 None D976N Tyrosine-protein kinase JAK2
5TQ5A 2.3 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 7GX Type1.5_Back 841 - 1131 0 None M1073S,F1076T Tyrosine-protein kinase JAK2
5TQ8A 1.59 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 7GS Type1.5_Back 841 - 1131 0 None M1073S,F1076T Tyrosine-protein kinase JAK2
7Q7IA 1.78 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9I8 Type1.5_Back 840 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
7Q7KA 1.61 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9I5 Type1.5_Back 840 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
7Q7LA 1.97 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9I2 Type1.5_Back 843 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
7Q7WA 1.85 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9HR Type1.5_Back 840 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
3JY9A 2.1 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai JZH Type1.5_Back 842 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
3KCKA 2.2 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 3KC Type1.5_Back 842 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
5HEZA 2.66 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oioao APEdist_aaao 1M3, 1M3 Allosteric, Type1 842 - 1132 0 PTR1007,PTR1008 P1057A Tyrosine-protein kinase JAK2
5HEZB 2.66 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oioao APEdist_aaao 1M3, 1M3 Allosteric, Type1 842 - 1132 0 PTR1007,PTR1008 P1057A Tyrosine-protein kinase JAK2
5HEZD 2.66 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oioao APEdist_aaao 1M3, 1M3 Allosteric, Type1 842 - 1132 0 PTR1007,PTR1008 P1057A Tyrosine-protein kinase JAK2
7UYWA 2.51 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai OV0 Type1 842 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
6BBVA 1.8 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai D7D Type1 843 - 1131 0 None None Tyrosine-protein kinase JAK2
6X8EA 1.75 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_nniai APEdist_aaai UWP Type1 843 - 1130 0 PTR1007,PTR1008 M1073S,F1076T Tyrosine-protein kinase JAK2
6X8EB 1.75 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_nniai APEdist_aaai UWP Type1 843 - 1132 0 PTR1007,PTR1008 M1073S,F1076T Tyrosine-protein kinase JAK2
7LL5A 1.5 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai Y5G Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2
2B7AA 2.0 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai IZA Type1 843 - 1132 0 PTR1007,PTR1008 N1129Q Tyrosine-protein kinase JAK2
2B7AB 2.0 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai IZA Type1 840 - 1132 0 PTR1007,PTR1008 N1129Q Tyrosine-protein kinase JAK2
3FUPA 2.4 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai MI1 Type1 843 - 1132 0 PTR1007,PTR1008 N1129Q Tyrosine-protein kinase JAK2
3FUPB 2.4 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai MI1 Type1 840 - 1132 0 PTR1007,PTR1008 N1129Q Tyrosine-protein kinase JAK2
4P7EA 2.4 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 2HB Type1 843 - 1132 0 PTR1007,PTR1008 N1129Q Tyrosine-protein kinase JAK2
4P7EB 2.4 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 2HB Type1 840 - 1132 0 PTR1007,PTR1008 N1129Q Tyrosine-protein kinase JAK2
3E62A 1.922 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 5B1 Type1 839 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
3E63A 1.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 5B2 Type1 840 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
3E64A 1.8 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 5B3 Type1 839 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
3KRRA 1.8 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai DQX Type1 840 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
3LPBA 2.0 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai NVB Type1 842 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
3LPBB 2.0 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai NVB Type1 840 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
5TQ6A 2.06 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 7GV Type1 843 - 1132 0 PTR1007,PTR1008 M1073S,F1076T Tyrosine-protein kinase JAK2
5TQ6B 2.06 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_nniai APEdist_aaai 7GV Type1 843 - 1130 0 PTR1007,PTR1008 M1073S,F1076T Tyrosine-protein kinase JAK2
5TQ7A 2.1 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 7GT Type1 841 - 1132 0 PTR1007,PTR1008 M1073S,F1076T,I1126V Tyrosine-protein kinase JAK2
5TQ7B 2.1 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 7GT Type1 843 - 1132 0 PTR1007,PTR1008 M1073S,F1076T,I1126V Tyrosine-protein kinase JAK2
7LL4A 1.31 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai Y5D Type1 839 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2
7REEA 1.38 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_nniai APEdist_aaai 4LY Type1 839 - 1130 0 PTR1007 None Tyrosine-protein kinase JAK2
4D0WA 1.77 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai VVQ Type1 839 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
4D0XA 1.82 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 953 Type1 839 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
5AEPA 1.95 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai QUP Type1 840 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
3TJCA 2.4 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0TP Type1 843 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
3TJCB 2.4 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0TP Type1 840 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
3TJDA 2.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 6TP Type1 843 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
3TJDB 2.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 6TP Type1 840 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
4HGEA 2.3 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 15V Type1 843 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
4HGEB 2.3 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 15V Type1 839 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
4IVAA 1.5 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 1J5 Type1 841 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
4JI9A 2.4 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao 1M3 Type1 843 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
4JI9B 2.4 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 1M3 Type1 839 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
3Q32A 2.5 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai J2I Type1 840 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
3Q32B 2.5 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_ooiai APEdist_aaai J2I Type1 839 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
5CF8A 1.8 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 50V Type1 842 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
5CF8B 1.8 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 50V Type1 839 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
4AQCA 1.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 88A Type1 842 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
4AQCB 1.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 88A Type1 836 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
4F08A 2.82 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 1RS Type1 843 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
4F08B 2.82 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 1RS Type1 843 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
4F09A 2.4 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai JAK Type1 843 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
4GFMA 2.3 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0X2 Type1 840 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
3RVGA 2.498 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_nniai APEdist_aaai 17P Type1 841 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
6VGLA 1.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai RXT Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2
6VGLB 1.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai RXT Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2
6VGLC 1.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai RXT Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2
6VGLD 1.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai RXT Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2
6VN8A 1.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 3JW Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2
6VN8B 1.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 3JW Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2
6VNBA 2.19 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R6P Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2
6VNBB 2.19 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R6P Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2
6VNCA 2.3 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R6V Type1 840 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2
6VNCB 2.3 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R6V Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2
6VNEA 2.32 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 2TA Type1 840 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2
6VNEB 2.32 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao 2TA Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2
6VNFA 2.06 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R6S Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2
6VNFB 2.06 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao R6S Type1 841 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2
6VNGA 2.5 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R6M Type1 841 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2
6VNGB 2.5 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_ioiai APEdist_aaai R6M Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2
6VNHA 2.4 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai XZS Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2
6VNHB 2.4 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao XZS Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2
6VNIA 2.1 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R61 Type1 842 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2
6VNIB 2.1 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao R61 Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2
6VNJA 1.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R5S Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2
6VNJB 1.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R5S Type1 842 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2
6VNKA 2.0 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai RXT Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2
6VNKB 2.0 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai RXT Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2
6VNKC 2.0 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao RXT Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2
6VNKD 2.0 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai RXT Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2
6VNLA 2.4 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 5W2 Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2
6VNLB 2.4 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 5W2 Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2
6VNLC 2.4 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao 5W2 Type1 842 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2
6VNLD 2.4 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao 5W2 Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2
6VNMA 2.2 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R5Y Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2
6VNMB 2.2 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R5Y Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2
6VS3A 2.0 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R6V Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2
6VS3B 2.0 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R6V Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2
6VSNA 2.5 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai RG4 Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2
6VSNB 2.5 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai RG4 Type1 842 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2
6VSNC 2.5 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai RG4 Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2
6VSND 2.5 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai RG4 Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2
6WTNA 1.83 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai RXT Type1 843 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
6WTOA 1.74 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_nniai APEdist_aaai 3JW Type1 843 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
6WTPA 2.5 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_nniai APEdist_aaai U8P Type1 844 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
6WTQA 1.8 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_nniai APEdist_aaao U8J Type1 849 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
8G6ZA 2.45 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai YSI Type1 843 - 1131 0 PTR1007 M1073S,F1076T Tyrosine-protein kinase JAK2
8G6ZB 2.45 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai YSI Type1 843 - 1131 0 PTR1007 M1073S,F1076T Tyrosine-protein kinase JAK2
8G8OA 2.2 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai YT0 Type1 842 - 1130 0 PTR1007,PTR1008 M1073S,F1076T Tyrosine-protein kinase JAK2
8G8OB 2.2 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai YT0 Type1 843 - 1130 0 PTR1007,PTR1008 M1073S,F1076T Tyrosine-protein kinase JAK2
8G8XA 1.97 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai YT8 Type1 842 - 1130 0 PTR1007,PTR1008 M1073S,F1076T Tyrosine-protein kinase JAK2
8G8XB 1.97 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai YT8 Type1 842 - 1130 0 PTR1007,PTR1008 M1073S,F1076T Tyrosine-protein kinase JAK2
3IO7A 2.6 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 1P5 Type1 842 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
3IOKA 2.1 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 1P6 Type1 842 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
8BX9A 1.4 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai S59 Type1 840 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
8BX9B 1.4 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai S59 Type1 840 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
8BXCA 1.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai S4R Type1 840 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
8BXCB 1.9 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai S4R Type1 840 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
8BXHA 1.3 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai C87 Type1 840 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
8BPVA 1.7 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 6T3 Type1 840 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
8BPWA 1.8 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 2V9 Type1 840 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
8BPWB 1.8 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 2V9 Type1 840 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
4ZIMA 2.65 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 4OK Type1 842 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
4ZIMB 2.65 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 4OK Type1 839 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
5CF4A 2.38 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 50Y Type1 843 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
5CF4B 2.38 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 50Y Type1 839 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
5CF5A 2.45 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaao 50W Type1 842 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
5CF5B 2.45 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 50W Type1 839 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
5CF6A 2.5 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 50O Type1 842 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
5CF6B 2.5 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 50O Type1 839 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
4E6DA 2.22 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0NU Type1 840 - 1132 0 PTR1007,PTR1008 Q853R,Y931F,D939E Tyrosine-protein kinase JAK2
4E6DB 2.22 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0NU Type1 840 - 1132 0 PTR1007,PTR1008 Q853R,Y931F,D939E Tyrosine-protein kinase JAK2
4E6QA 1.948 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao 0NV Type1 835 - 1132 0 PTR1007,PTR1008 Q853R,Y931F,D939E Tyrosine-protein kinase JAK2
4E6QB 1.948 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao 0NV Type1 835 - 1132 0 PTR1007,PTR1008 Q853R,Y931F,D939E Tyrosine-protein kinase JAK2
2XA4A 2.04 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai AZ5 Type1 843 - 1130 0 PTR1007,PTR1008 K943A,K945A Tyrosine-protein kinase JAK2
2XA4B 2.04 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai AZ5 Type1 843 - 1131 0 PTR1007,PTR1008 K943A,K945A Tyrosine-protein kinase JAK2
3ZMMA 2.51 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai F9J Type1 844 - 1130 0 PTR1007,PTR1008 K943A,K945A Tyrosine-protein kinase JAK2
3ZMMB 2.51 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai F9J Type1 843 - 1131 0 PTR1007,PTR1008 K943A,K945A Tyrosine-protein kinase JAK2
4C61A 2.45 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai LMM Type1 844 - 1130 0 PTR1007,PTR1008 K943A,K945A Tyrosine-protein kinase JAK2
4C61B 2.45 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai LMM Type1 843 - 1131 0 PTR1007,PTR1008 K943A,K945A Tyrosine-protein kinase JAK2
4C62A 2.75 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai XWW Type1 844 - 1130 0 PTR1007,PTR1008 K943A,K945A Tyrosine-protein kinase JAK2
4C62B 2.75 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai XWW Type1 843 - 1131 0 PTR1007,PTR1008 K943A,K945A Tyrosine-protein kinase JAK2
5HEZC 2.66 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oioao APEdist_aaao 1M3, 1M3 Type1, Allosteric 842 - 1132 0 PTR1007,PTR1008 P1057A Tyrosine-protein kinase JAK2
2W1IB 2.6 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 843 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
6DRWA 2.303 Inactive DFGin‑BLAminus in-out in-none TYR APEdihe_nniai APEdist_aaai SKE Type1 840 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2
6TPDA 1.99 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai QZ8 Type1 842 - 1130 0 None None Tyrosine-protein kinase JAK2
5TQ4A 2.3 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao 7GY Type1.5_Back 841 - 1132 0 PTR1007,PTR1008 M1073S,F1076T Tyrosine-protein kinase JAK2
5TQ3A 2.69 Inactive DFGin‑None in-in in-in TYR APEdihe_iiiai APEdist_aaai 7GZ Type1.5_Back 843 - 1132 0 PTR1007,PTR1008 M1073S,F1076T,I1126V Tyrosine-protein kinase JAK2
5TQ3B 2.69 Inactive DFGin‑None in-in in-in TYR APEdihe_iiiai APEdist_aaai 7GZ Type1.5_Back 843 - 1132 0 PTR1007,PTR1008 M1073S,F1076T,I1126V Tyrosine-protein kinase JAK2
7RN6A 1.5 Inactive DFGout‑BBAminus in-in none-out TYR APEdihe_nioai APEdist_aaao 046 Type2 839 - 1130 0 PTR1007 None Tyrosine-protein kinase JAK2
3UGCA 1.34 Inactive DFGout‑BBAminus in-in out-out TYR APEdihe_oioai APEdist_aaao 046 Type2 843 - 1129 0 None Y1007F,Y1008F Tyrosine-protein kinase JAK2
7TEUA 1.45 Inactive DFGout‑BBAminus in-in out-out TYR APEdihe_oioai APEdist_aaao I6C Type2 843 - 1131 0 None Y1007F,Y1008F Tyrosine-protein kinase JAK2
4D1SA 1.66 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai BJG Type1 842 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
5USYA 2.0 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai SKE Type1 840 - 1130 0 PTR1007 None Tyrosine-protein kinase JAK2
5USYB 2.0 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai SKE Type1 840 - 1130 0 PTR1007 None Tyrosine-protein kinase JAK2

TYR_JAK2-2 (Tyrosine-protein kinase JAK2)

Total number of chains: 180
Active chains: 37
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 128 71.1% 8BXHA
DFGin BLAminus 47 26.1% AF-O60674-K2A
DFGout BBAminus 3 1.7% 3UGCA
DFGin None 2 1.1% 5TQ3B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
JAK2_HUMAN AF-O60674-K2A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 841 - 1132 0 None None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN AF-O60674-K4A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 841 - 1132 0 None None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4YTCA 2.16 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 4HW Type1 842 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4YTFA 1.78 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 4HZ Type1 842 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4YTHA 2.04 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 467 Type1 842 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4YTIA 2.52 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai VJK Type1 842 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4JIAA 1.85 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 1K3 Type1 833 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4E4MA 2.25 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0NH Type1 835 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4E4MB 2.25 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0NH Type1 835 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4E4MD 2.25 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0NH Type1 835 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4E4ME 2.25 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0NH Type1 835 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4GMYA 2.403 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0X5 Type1 833 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8BX6A 1.5 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai S5I Type1 840 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8BM2A 1.5 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai QQC Type1 840 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8BM2B 1.5 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai QQC Type1 840 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5WEVA 1.854 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9ZS Type1 833 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 2W1IA 2.6 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai L0I Type1 843 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5L3AA 1.98 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 6DP Type1 841 - 1130 0 None Y1007F,Y1008F Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6AAJA 2.37 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9T6 Type1 843 - 1130 0 PTR1007,PTR1008 K943A,K945A Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6AAJB 2.37 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9T6 Type1 843 - 1131 0 PTR1007,PTR1008 K943A,K945A Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4BBEA 1.9 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 3O4 Type1 841 - 1128 0 None D976N Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4BBEB 1.9 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 3O4 Type1 841 - 1128 0 None D976N Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4BBEC 1.9 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 3O4 Type1 841 - 1128 0 None D976N Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4BBED 1.9 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 3O4 Type1 841 - 1128 0 None D976N Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4BBFA 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai O19 Type1 841 - 1128 0 None D976N Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4BBFB 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai O19 Type1 841 - 1128 0 None D976N Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4BBFC 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai O19 Type1 841 - 1128 0 None D976N Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4BBFD 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai O19 Type1 841 - 1128 0 None D976N Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5TQ5A 2.3 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 7GX Type1.5_Back 841 - 1131 0 None M1073S,F1076T Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5TQ8A 1.59 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 7GS Type1.5_Back 841 - 1131 0 None M1073S,F1076T Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 7Q7IA 1.78 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9I8 Type1.5_Back 840 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 7Q7KA 1.61 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9I5 Type1.5_Back 840 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 7Q7LA 1.97 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9I2 Type1.5_Back 843 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 7Q7WA 1.85 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9HR Type1.5_Back 840 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 3JY9A 2.1 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai JZH Type1.5_Back 842 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 3KCKA 2.2 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 3KC Type1.5_Back 842 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5HEZA 2.66 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oioao APEdist_aaao 1M3, 1M3 Allosteric, Type1 842 - 1132 0 PTR1007,PTR1008 P1057A Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5HEZB 2.66 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oioao APEdist_aaao 1M3, 1M3 Allosteric, Type1 842 - 1132 0 PTR1007,PTR1008 P1057A Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5HEZD 2.66 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oioao APEdist_aaao 1M3, 1M3 Allosteric, Type1 842 - 1132 0 PTR1007,PTR1008 P1057A Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 7UYWA 2.51 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai OV0 Type1 842 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6BBVA 1.8 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai D7D Type1 843 - 1131 0 None None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6X8EA 1.75 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_nniai APEdist_aaai UWP Type1 843 - 1130 0 PTR1007,PTR1008 M1073S,F1076T Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6X8EB 1.75 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_nniai APEdist_aaai UWP Type1 843 - 1132 0 PTR1007,PTR1008 M1073S,F1076T Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 7LL5A 1.5 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai Y5G Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 2B7AA 2.0 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai IZA Type1 843 - 1132 0 PTR1007,PTR1008 N1129Q Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 2B7AB 2.0 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai IZA Type1 840 - 1132 0 PTR1007,PTR1008 N1129Q Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 3FUPA 2.4 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai MI1 Type1 843 - 1132 0 PTR1007,PTR1008 N1129Q Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 3FUPB 2.4 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai MI1 Type1 840 - 1132 0 PTR1007,PTR1008 N1129Q Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4P7EA 2.4 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 2HB Type1 843 - 1132 0 PTR1007,PTR1008 N1129Q Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4P7EB 2.4 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 2HB Type1 840 - 1132 0 PTR1007,PTR1008 N1129Q Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 3E62A 1.922 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 5B1 Type1 839 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 3E63A 1.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 5B2 Type1 840 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 3E64A 1.8 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 5B3 Type1 839 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 3KRRA 1.8 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai DQX Type1 840 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 3LPBA 2.0 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai NVB Type1 842 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 3LPBB 2.0 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai NVB Type1 840 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5TQ6A 2.06 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 7GV Type1 843 - 1132 0 PTR1007,PTR1008 M1073S,F1076T Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5TQ6B 2.06 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_nniai APEdist_aaai 7GV Type1 843 - 1130 0 PTR1007,PTR1008 M1073S,F1076T Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5TQ7A 2.1 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 7GT Type1 841 - 1132 0 PTR1007,PTR1008 M1073S,F1076T,I1126V Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5TQ7B 2.1 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 7GT Type1 843 - 1132 0 PTR1007,PTR1008 M1073S,F1076T,I1126V Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 7LL4A 1.31 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai Y5D Type1 839 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 7REEA 1.38 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_nniai APEdist_aaai 4LY Type1 839 - 1130 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4D0WA 1.77 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai VVQ Type1 839 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4D0XA 1.82 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 953 Type1 839 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5AEPA 1.95 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai QUP Type1 840 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 3TJCA 2.4 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0TP Type1 843 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 3TJCB 2.4 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0TP Type1 840 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 3TJDA 2.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 6TP Type1 843 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 3TJDB 2.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 6TP Type1 840 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4HGEA 2.3 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 15V Type1 843 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4HGEB 2.3 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 15V Type1 839 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4IVAA 1.5 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 1J5 Type1 841 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4JI9A 2.4 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao 1M3 Type1 843 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4JI9B 2.4 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 1M3 Type1 839 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 3Q32A 2.5 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai J2I Type1 840 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 3Q32B 2.5 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_ooiai APEdist_aaai J2I Type1 839 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5CF8A 1.8 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 50V Type1 842 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5CF8B 1.8 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 50V Type1 839 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4AQCA 1.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 88A Type1 842 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4AQCB 1.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 88A Type1 836 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4F08A 2.82 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 1RS Type1 843 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4F08B 2.82 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 1RS Type1 843 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4F09A 2.4 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai JAK Type1 843 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4GFMA 2.3 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0X2 Type1 840 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 3RVGA 2.498 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_nniai APEdist_aaai 17P Type1 841 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VGLA 1.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai RXT Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VGLB 1.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai RXT Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VGLC 1.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai RXT Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VGLD 1.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai RXT Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VN8A 1.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 3JW Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VN8B 1.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 3JW Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VNBA 2.19 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R6P Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VNBB 2.19 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R6P Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VNCA 2.3 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R6V Type1 840 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VNCB 2.3 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R6V Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VNEA 2.32 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 2TA Type1 840 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VNEB 2.32 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao 2TA Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VNFA 2.06 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R6S Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VNFB 2.06 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao R6S Type1 841 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VNGA 2.5 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R6M Type1 841 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VNGB 2.5 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_ioiai APEdist_aaai R6M Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VNHA 2.4 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai XZS Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VNHB 2.4 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao XZS Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VNIA 2.1 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R61 Type1 842 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VNIB 2.1 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao R61 Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VNJA 1.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R5S Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VNJB 1.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R5S Type1 842 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VNKA 2.0 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai RXT Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VNKB 2.0 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai RXT Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VNKC 2.0 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao RXT Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VNKD 2.0 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai RXT Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VNLA 2.4 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 5W2 Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VNLB 2.4 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 5W2 Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VNLC 2.4 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao 5W2 Type1 842 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VNLD 2.4 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao 5W2 Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VNMA 2.2 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R5Y Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VNMB 2.2 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R5Y Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VS3A 2.0 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R6V Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VS3B 2.0 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R6V Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VSNA 2.5 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai RG4 Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VSNB 2.5 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai RG4 Type1 842 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VSNC 2.5 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai RG4 Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6VSND 2.5 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai RG4 Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6WTNA 1.83 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai RXT Type1 843 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6WTOA 1.74 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_nniai APEdist_aaai 3JW Type1 843 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6WTPA 2.5 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_nniai APEdist_aaai U8P Type1 844 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6WTQA 1.8 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_nniai APEdist_aaao U8J Type1 849 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8G6ZA 2.45 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai YSI Type1 843 - 1131 0 PTR1007 M1073S,F1076T Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8G6ZB 2.45 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai YSI Type1 843 - 1131 0 PTR1007 M1073S,F1076T Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8G8OA 2.2 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai YT0 Type1 842 - 1130 0 PTR1007,PTR1008 M1073S,F1076T Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8G8OB 2.2 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai YT0 Type1 843 - 1130 0 PTR1007,PTR1008 M1073S,F1076T Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8G8XA 1.97 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai YT8 Type1 842 - 1130 0 PTR1007,PTR1008 M1073S,F1076T Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8G8XB 1.97 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai YT8 Type1 842 - 1130 0 PTR1007,PTR1008 M1073S,F1076T Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 3IO7A 2.6 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 1P5 Type1 842 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 3IOKA 2.1 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 1P6 Type1 842 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8BX9A 1.4 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai S59 Type1 840 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8BX9B 1.4 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai S59 Type1 840 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8BXCA 1.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai S4R Type1 840 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8BXCB 1.9 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai S4R Type1 840 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8BXHA 1.3 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai C87 Type1 840 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8BPVA 1.7 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 6T3 Type1 840 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8BPWA 1.8 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 2V9 Type1 840 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8BPWB 1.8 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 2V9 Type1 840 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4ZIMA 2.65 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 4OK Type1 842 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4ZIMB 2.65 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 4OK Type1 839 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5CF4A 2.38 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 50Y Type1 843 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5CF4B 2.38 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 50Y Type1 839 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5CF5A 2.45 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaao 50W Type1 842 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5CF5B 2.45 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 50W Type1 839 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5CF6A 2.5 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 50O Type1 842 - 1131 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5CF6B 2.5 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 50O Type1 839 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4E6DA 2.22 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0NU Type1 840 - 1132 0 PTR1007,PTR1008 Q853R,Y931F,D939E Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4E6DB 2.22 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0NU Type1 840 - 1132 0 PTR1007,PTR1008 Q853R,Y931F,D939E Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4E6QA 1.948 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao 0NV Type1 835 - 1132 0 PTR1007,PTR1008 Q853R,Y931F,D939E Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4E6QB 1.948 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao 0NV Type1 835 - 1132 0 PTR1007,PTR1008 Q853R,Y931F,D939E Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 2XA4A 2.04 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai AZ5 Type1 843 - 1130 0 PTR1007,PTR1008 K943A,K945A Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 2XA4B 2.04 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai AZ5 Type1 843 - 1131 0 PTR1007,PTR1008 K943A,K945A Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 3ZMMA 2.51 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai F9J Type1 844 - 1130 0 PTR1007,PTR1008 K943A,K945A Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 3ZMMB 2.51 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai F9J Type1 843 - 1131 0 PTR1007,PTR1008 K943A,K945A Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4C61A 2.45 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai LMM Type1 844 - 1130 0 PTR1007,PTR1008 K943A,K945A Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4C61B 2.45 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai LMM Type1 843 - 1131 0 PTR1007,PTR1008 K943A,K945A Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4C62A 2.75 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai XWW Type1 844 - 1130 0 PTR1007,PTR1008 K943A,K945A Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4C62B 2.75 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai XWW Type1 843 - 1131 0 PTR1007,PTR1008 K943A,K945A Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5HEZC 2.66 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oioao APEdist_aaao 1M3, 1M3 Type1, Allosteric 842 - 1132 0 PTR1007,PTR1008 P1057A Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 2W1IB 2.6 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 843 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6DRWA 2.303 Inactive DFGin‑BLAminus in-out in-none TYR APEdihe_nniai APEdist_aaai SKE Type1 840 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6TPDA 1.99 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai QZ8 Type1 842 - 1130 0 None None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5TQ4A 2.3 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao 7GY Type1.5_Back 841 - 1132 0 PTR1007,PTR1008 M1073S,F1076T Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5TQ3A 2.69 Inactive DFGin‑None in-in in-in TYR APEdihe_iiiai APEdist_aaai 7GZ Type1.5_Back 843 - 1132 0 PTR1007,PTR1008 M1073S,F1076T,I1126V Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5TQ3B 2.69 Inactive DFGin‑None in-in in-in TYR APEdihe_iiiai APEdist_aaai 7GZ Type1.5_Back 843 - 1132 0 PTR1007,PTR1008 M1073S,F1076T,I1126V Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 7RN6A 1.5 Inactive DFGout‑BBAminus in-in none-out TYR APEdihe_nioai APEdist_aaao 046 Type2 839 - 1130 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 3UGCA 1.34 Inactive DFGout‑BBAminus in-in out-out TYR APEdihe_oioai APEdist_aaao 046 Type2 843 - 1129 0 None Y1007F,Y1008F Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 7TEUA 1.45 Inactive DFGout‑BBAminus in-in out-out TYR APEdihe_oioai APEdist_aaao I6C Type2 843 - 1131 0 None Y1007F,Y1008F Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4D1SA 1.66 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai BJG Type1 842 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5USYA 2.0 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai SKE Type1 840 - 1130 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5USYB 2.0 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai SKE Type1 840 - 1130 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_MOUSE 4GL9D 3.9 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai IZA Type1 843 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Mus musculus
JAK2_MOUSE 4GL9A 3.9 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao IZA Type1 843 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Mus musculus
JAK2_MOUSE 4GL9B 3.9 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao IZA Type1 843 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Mus musculus
JAK2_MOUSE 4GL9C 3.9 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao IZA Type1 843 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Mus musculus

TYR_JAK2-2 (Tyrosine-protein kinase JAK2)

Total number of chains: 4
Active chains: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 4GL9D
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
JAK2_MOUSE 4GL9D 3.9 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai IZA Type1 843 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Mus musculus
JAK2_MOUSE 4GL9A 3.9 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao IZA Type1 843 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Mus musculus
JAK2_MOUSE 4GL9B 3.9 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao IZA Type1 843 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Mus musculus
JAK2_MOUSE 4GL9C 3.9 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao IZA Type1 843 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Mus musculus