Ligand: IZA

Total number of chains: 8
Active chains: 1
Total number of genes: 5
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 62.5% 3LXLA
DFGin ABAminus 3 37.5% 3EYHA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
CAMK DAPK3 DAPK3_HUMAN 2J90A 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno IZA Type1 5 - 278 0 SEP50,TPO265 None Death-associated protein kinase 3
CAMK DAPK3 DAPK3_HUMAN 2J90B 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oooo IZA Type1 12 - 280 0 SEP50,TPO265 None Death-associated protein kinase 3
TYR JAK1-2 JAK1_HUMAN 3EYHA 2.0 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai IZA Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
TYR JAK2-2 JAK2_HUMAN 2B7AA 2.0 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai IZA Type1 843 - 1132 0 PTR1007,PTR1008 N1129Q Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 2B7AB 2.0 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai IZA Type1 840 - 1132 0 PTR1007,PTR1008 N1129Q Tyrosine-protein kinase JAK2
TYR JAK3-2 JAK3_HUMAN 3LXLA 1.74 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai IZA Type1 814 - 1098 0 None C1048S Tyrosine-protein kinase JAK3
TYR TYK2-2 TYK2_HUMAN 3LXPA 1.65 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai IZA Type1 888 - 1178 0 PTR1054 C936A,Q969A,E971A,K972A,C1142A Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-2 TYK2_HUMAN 3NZ0A 2.0 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_ioiai APEdist_aaai IZA Type1 888 - 1176 0 None D1023N Non-receptor tyrosine-protein kinase TYK2

Ligand: IZA

Total number of chains: 14
Active chains: 2
Total number of genes: 6
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 9 64.3% 3LXLA
DFGin ABAminus 5 35.7% 3EYHA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CAMK DAPK3 DAPK3_HUMAN 2J90A 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno IZA Type1 5 - 278 0 SEP50,TPO265 None Death-associated protein kinase 3 Homo sapiens
CAMK DAPK3 DAPK3_HUMAN 2J90B 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oooo IZA Type1 12 - 280 0 SEP50,TPO265 None Death-associated protein kinase 3 Homo sapiens
TYR JAK1-2 JAK1_HUMAN 3EYHA 2.0 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai IZA Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
TYR JAK2-2 JAK2_HUMAN 2B7AA 2.0 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai IZA Type1 843 - 1132 0 PTR1007,PTR1008 N1129Q Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-2 JAK2_HUMAN 2B7AB 2.0 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai IZA Type1 840 - 1132 0 PTR1007,PTR1008 N1129Q Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK3-2 JAK3_HUMAN 3LXLA 1.74 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai IZA Type1 814 - 1098 0 None C1048S Tyrosine-protein kinase JAK3 Homo sapiens
TYR TYK2-2 TYK2_HUMAN 3LXPA 1.65 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai IZA Type1 888 - 1178 0 PTR1054 C936A,Q969A,E971A,K972A,C1142A Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-2 TYK2_HUMAN 3NZ0A 2.0 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_ioiai APEdist_aaai IZA Type1 888 - 1176 0 None D1023N Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR JAK2-2 JAK2_MOUSE 4GL9A 3.9 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao IZA Type1 843 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Mus musculus
TYR JAK2-2 JAK2_MOUSE 4GL9B 3.9 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao IZA Type1 843 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Mus musculus
TYR JAK2-2 JAK2_MOUSE 4GL9C 3.9 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao IZA Type1 843 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Mus musculus
TYR JAK2-2 JAK2_MOUSE 4GL9D 3.9 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai IZA Type1 843 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Mus musculus
OTHER IRE1 IRE1_YEAST 3LJ2A 3.33 Inactive DFGin‑ABAminus in-in in-none nonTYR APEdihe_aanni APEdist_nnnn IZA Type1 665 - 1115 0 SEP840,SEP841,TPO844 None Serine/threonine-protein kinase/endoribonuclease IRE1 Saccharomyces cerevisiae
OTHER IRE1 IRE1_YEAST 3LJ2B 3.33 Inactive DFGin‑ABAminus in-in in-none nonTYR APEdihe_aanni APEdist_nnnn IZA Type1 665 - 1115 0 SEP840,SEP841,TPO844 None Serine/threonine-protein kinase/endoribonuclease IRE1 Saccharomyces cerevisiae

Ligand: IZA

Total number of chains: 6
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 66.7% 4GL9A
DFGin ABAminus 2 33.3% 3LJ2A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYR JAK2-2 JAK2_MOUSE 4GL9A 3.9 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao IZA Type1 843 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Mus musculus
TYR JAK2-2 JAK2_MOUSE 4GL9B 3.9 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao IZA Type1 843 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Mus musculus
TYR JAK2-2 JAK2_MOUSE 4GL9C 3.9 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao IZA Type1 843 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Mus musculus
TYR JAK2-2 JAK2_MOUSE 4GL9D 3.9 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai IZA Type1 843 - 1130 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Mus musculus
OTHER IRE1 IRE1_YEAST 3LJ2A 3.33 Inactive DFGin‑ABAminus in-in in-none nonTYR APEdihe_aanni APEdist_nnnn IZA Type1 665 - 1115 0 SEP840,SEP841,TPO844 None Serine/threonine-protein kinase/endoribonuclease IRE1 Saccharomyces cerevisiae
OTHER IRE1 IRE1_YEAST 3LJ2B 3.33 Inactive DFGin‑ABAminus in-in in-none nonTYR APEdihe_aanni APEdist_nnnn IZA Type1 665 - 1115 0 SEP840,SEP841,TPO844 None Serine/threonine-protein kinase/endoribonuclease IRE1 Saccharomyces cerevisiae