Protein kinases in complex with RXT (Ruxolitinib)

Total number of genes: 2
Total number of chains: 11
Spatial Dihedral Chains Representative
DFGin BLAminus 1 7F3GA
DFGin ABAminus 10 6VGLA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
CAMK DCLK1 DCLK1_HUMAN Serine/threonine-protein kinase DCLK1 7F3GB 2.1 Inactive DFGin ABAminus in-in in-in RXT Type1
CAMK DCLK1 DCLK1_HUMAN Serine/threonine-protein kinase DCLK1 7F3GA 2.1 Active DFGin BLAminus in-in in-in RXT Type1
TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 6VGLA 1.9 Inactive DFGin ABAminus in-in in-in RXT Type1
TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 6VGLB 1.9 Inactive DFGin ABAminus in-in in-in RXT Type1
TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 6VGLC 1.9 Inactive DFGin ABAminus in-in in-in RXT Type1
TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 6VGLD 1.9 Inactive DFGin ABAminus in-in in-in RXT Type1
TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 6VNKA 2.0 Inactive DFGin ABAminus in-in in-in RXT Type1
TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 6VNKB 2.0 Inactive DFGin ABAminus in-in in-in RXT Type1
TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 6VNKC 2.0 Inactive DFGin ABAminus in-in in-out RXT Type1
TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 6VNKD 2.0 Inactive DFGin ABAminus in-in in-in RXT Type1
TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 6WTNA 1.83 Inactive DFGin ABAminus in-in in-in RXT Type1

Protein kinases in complex with RXT

Total number of genes: 3
Total number of chains: 13
Spatial Dihedral Chains Representative
DFGin BLAminus 3 7F3GA
DFGin ABAminus 10 6VGLA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Gallus gallus TYR SRC SRC_CHICK Proto-oncogene tyrosine-protein kinase Src 4U5JA 2.26 Inactive DFGin BLAminus in-out in-in RXT Type1
Gallus gallus TYR SRC SRC_CHICK Proto-oncogene tyrosine-protein kinase Src 4U5JB 2.26 Inactive DFGin BLAminus in-out in-in RXT Type1
Homo sapiens CAMK DCLK1 DCLK1_HUMAN Serine/threonine-protein kinase DCLK1 7F3GB 2.1 Inactive DFGin ABAminus in-in in-in RXT Type1
Homo sapiens CAMK DCLK1 DCLK1_HUMAN Serine/threonine-protein kinase DCLK1 7F3GA 2.1 Active DFGin BLAminus in-in in-in RXT Type1
Homo sapiens TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 6VGLA 1.9 Inactive DFGin ABAminus in-in in-in RXT Type1
Homo sapiens TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 6VGLB 1.9 Inactive DFGin ABAminus in-in in-in RXT Type1
Homo sapiens TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 6VGLC 1.9 Inactive DFGin ABAminus in-in in-in RXT Type1
Homo sapiens TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 6VGLD 1.9 Inactive DFGin ABAminus in-in in-in RXT Type1
Homo sapiens TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 6VNKA 2.0 Inactive DFGin ABAminus in-in in-in RXT Type1
Homo sapiens TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 6VNKB 2.0 Inactive DFGin ABAminus in-in in-in RXT Type1
Homo sapiens TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 6VNKC 2.0 Inactive DFGin ABAminus in-in in-out RXT Type1
Homo sapiens TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 6VNKD 2.0 Inactive DFGin ABAminus in-in in-in RXT Type1
Homo sapiens TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 6WTNA 1.83 Inactive DFGin ABAminus in-in in-in RXT Type1

Protein kinases in complex with RXT

Total number of genes: 1
Total number of chains: 2
Spatial Dihedral Chains Representative
DFGin BLAminus 2 4U5JA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Gallus gallus TYR SRC SRC_CHICK Proto-oncogene tyrosine-protein kinase Src 4U5JA 2.26 Inactive DFGin BLAminus in-out in-in RXT Type1
Gallus gallus TYR SRC SRC_CHICK Proto-oncogene tyrosine-protein kinase Src 4U5JB 2.26 Inactive DFGin BLAminus in-out in-in RXT Type1