Ligand: 2TA (Fedratinib, Inrebic)

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 100.0% 6VNEA

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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TYR JAK2-2 JAK2_HUMAN 6VNEA 2.32 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 2TA Type1 840 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 6VNEB 2.32 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao 2TA Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2

Ligand: 2TA (Fedratinib, Inrebic)

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 100.0% 6VNEA

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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYR JAK2-2 JAK2_HUMAN 6VNEA 2.32 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 2TA Type1 840 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-2 JAK2_HUMAN 6VNEB 2.32 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao 2TA Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens

Ligand: 2TA (Fedratinib, Inrebic)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Hover over column headers for tooltip help

Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism