TYR_JAK2-2 (Tyrosine-protein kinase JAK2)

Total number of chains: 176
Active chains: 36
Family: TYR
Uniprot: JAK2_HUMAN
Kinase Domain Residues: 849 - 1125
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 128 72.7% 8BXHA
DFGin BLAminus 43 24.4% AF-O60674-K2A
DFGout BBAminus 3 1.7% 3UGCA
DFGin None 2 1.1% 5TQ3B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-O60674-K2A 841 1132 1132.0 No_ligand No_ligand Active DFGin 6.076 13.511 BLAminus -134.61, -173.69 52.08, 73.04 -83.89, 16.61 294.74, 89.28 -62.65, -26.85 in-in in 8.222 Saltbr-in 2.679 HRD-in -66.64, -44.29 64.49, -16.9 in-in-in SNCiii in-in ActLoopNT-in 2.873 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.63, 129.01 APE9-dihe-in -134.95, 135.87 APE8-dihe-in -76.24, 67.38 APE8-rot-na 35.11 APE67-dihe-in -76.66, -11.38 -54.24, -26.75 APE12-dist-na 10.548 APE11-dist-na 9.777 APE10-dist-na 10.368 APE9-dist-in 7.016 None None None AF2 -1.0 1.0 1.0 A 292 292 0 0 0 0 [[545, 807], [849, 1125]] 2.0 AF-O60674-K2 TYR_JAK2-2_HUMAN TYR 2.4e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
AF-O60674-K4A 841 1132 1132.0 No_ligand No_ligand Active DFGin 6.183 13.728 BLAminus -124.83, -169.75 47.53, 87.52 -95.54, 11.39 291.22, 87.41 -58.23, -35.02 in-in in 8.101 Saltbr-in 2.69 HRD-in -71.89, -46.5 63.37, -4.19 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -53.03, 124.77 APE9-dihe-in -142.44, 144.76 APE8-dihe-in -76.91, 66.4 APE8-rot-na 36.22 APE67-dihe-in -74.84, -12.36 -51.58, -31.85 APE12-dist-na 12.698 APE11-dist-na 9.962 APE10-dist-na 10.367 APE9-dist-in 6.61 None None None AF2 -1.0 1.0 1.0 A 292 292 0 0 0 0 [[545, 807], [849, 1125]] 2.0 AF-O60674-K4 TYR_JAK2-2_HUMAN TYR 2.4e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4YTCA 842 1130 1132.0 4HW:4000 Type1 Active DFGin 6.284 13.631 BLAminus -129.66, -176.22 51.29, 90.56 -102.75, 24.38 294.82, 85.35 -54.0, -39.57 in-in in 8.35 Saltbr-in 2.805 HRD-in -56.35, -51.38 71.22, -20.89 in-in-in SNCiii in-in ActLoopNT-in 2.788 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.0, 125.77 APE9-dihe-in -125.82, 130.76 APE8-dihe-in -79.99, 71.65 APE8-rot-na 31.05 APE67-dihe-in -75.16, -3.9 -53.22, -32.81 APE12-dist-na 10.704 APE11-dist-na 9.782 APE10-dist-na 9.936 APE9-dist-in 7.17 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.16 0.191 0.213 A 296 286 3 0 0 0 [[545, 807], [849, 1125]] 2.0 4ytc TYR_JAK2-2_HUMAN TYR 2.5e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4YTFA 842 1130 1132.0 4HZ:4000 Type1 Active DFGin 6.37 13.978 BLAminus -125.72, -175.3 45.63, 83.96 -89.3, 17.99 291.34, 92.01 -59.67, -25.51 in-in in 8.149 Saltbr-in 2.876 HRD-in -60.23, -48.26 68.84, -2.8 in-in-in SNCiii in-in ActLoopNT-in 2.841 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -61.86, 130.64 APE9-dihe-in -127.42, 133.95 APE8-dihe-in -81.26, 70.38 APE8-rot-na 32.03 APE67-dihe-in -72.41, -3.79 -52.3, -34.22 APE12-dist-na 10.964 APE11-dist-na 9.902 APE10-dist-na 10.371 APE9-dist-in 7.059 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.78 0.184 0.213 A 296 285 4 0 0 0 [[545, 807], [849, 1125]] 2.0 4ytf TYR_JAK2-2_HUMAN TYR 2.5e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4YTHA 842 1130 1132.0 467:4000 Type1 Active DFGin 6.501 14.25 BLAminus -123.79, 177.05 52.02, 90.63 -96.87, 16.55 287.94, 81.01 -60.81, -22.17 in-in in 8.35 Saltbr-in 2.868 HRD-in -56.47, -50.57 69.99, -4.7 in-in-in SNCiii in-in ActLoopNT-in 2.789 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.19, 125.25 APE9-dihe-in -116.48, 132.76 APE8-dihe-in -83.33, 72.42 APE8-rot-na 31.59 APE67-dihe-in -74.94, -3.66 -52.89, -33.66 APE12-dist-na 11.091 APE11-dist-na 9.973 APE10-dist-na 10.603 APE9-dist-in 7.355 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.04 0.185 0.215 A 296 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4yth TYR_JAK2-2_HUMAN TYR 2.5e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4YTIA 842 1130 1132.0 VJK:4000 Type1 Active DFGin 6.453 14.042 BLAminus -111.73, 173.97 45.15, 104.18 -106.31, 17.15 289.25, 83.82 -59.01, -26.24 in-in in 8.296 Saltbr-in 2.892 HRD-in -56.28, -51.06 69.78, -6.88 in-in-in SNCiii in-in ActLoopNT-in 2.787 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.56, 124.89 APE9-dihe-in -117.8, 129.73 APE8-dihe-in -82.47, 72.1 APE8-rot-na 31.97 APE67-dihe-in -75.31, -3.93 -52.08, -34.26 APE12-dist-na 10.981 APE11-dist-na 9.838 APE10-dist-na 10.188 APE9-dist-in 7.242 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.52 0.208 0.217 A 296 286 3 0 0 0 [[545, 807], [849, 1125]] 2.0 4yti TYR_JAK2-2_HUMAN TYR 2.5e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4JIAA 833 1132 1132.0 1K3:1201 Type1 Active DFGin 6.364 14.47 BLAminus -122.4, -163.0 65.63, 62.41 -96.29, 10.16 289.43, 100.3 -68.57, -11.9 in-in in 8.392 Saltbr-in 2.997 HRD-in -71.65, -49.59 74.75, -2.34 in-in-in SNCiii in-in ActLoopNT-in 2.792 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.81, 146.85 APE9-dihe-in -121.32, 149.01 APE8-dihe-in -77.17, 68.16 APE8-rot-na 29.8 APE67-dihe-in -77.58, -3.98 -58.25, -30.19 APE12-dist-na 13.472 APE11-dist-na 13.148 APE10-dist-na 13.123 APE9-dist-in 7.946 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.85 0.172 0.202 A 300 300 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4jia TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4E4MA 835 1132 1132.0 0NH:1201 Type1 Active DFGin 6.18 13.838 BLAminus -126.63, -156.25 24.74, 86.17 -92.72, 21.67 300.1, 90.36 -63.44, -19.58 in-in in 8.414 Saltbr-in 2.778 HRD-in -66.9, -48.08 75.55, -2.59 in-in-in SNCiii in-in ActLoopNT-in 2.676 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.21, 124.91 APE9-dihe-in -103.01, 150.72 APE8-dihe-in -78.71, 77.02 APE8-rot-na 32.56 APE67-dihe-in -75.65, -0.18 -64.92, -29.56 APE12-dist-na 13.669 APE11-dist-na 12.915 APE10-dist-na 12.815 APE9-dist-in 7.815 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.25 0.193 0.25 A 302 298 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4e4m TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4E4MB 835 1132 1132.0 0NH:1201 Type1 Active DFGin 6.372 14.203 BLAminus -118.84, -161.19 49.92, 72.51 -97.78, 25.28 298.31, 88.24 -69.84, -19.78 in-in in 8.441 Saltbr-in 2.744 HRD-in -61.1, -46.48 75.69, -8.22 in-in-in SNCiii in-in ActLoopNT-in 2.827 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.14, 74.01 APE9-dihe-in -58.89, 145.08 APE8-dihe-in -79.55, 72.25 APE8-rot-na 32.4 APE67-dihe-in -77.95, -3.75 -58.02, -29.09 APE12-dist-na 14.044 APE11-dist-na 12.156 APE10-dist-na 12.903 APE9-dist-in 7.921 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.25 0.193 0.25 B 302 298 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4e4m TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4E4MD 835 1132 1132.0 0NH:1201 Type1 Active DFGin 6.304 14.131 BLAminus -117.3, -162.8 35.37, 82.7 -96.62, 19.05 298.07, 93.7 -70.19, -12.95 in-in in 8.496 Saltbr-in 3.227 HRD-in -71.15, -48.12 79.59, -3.5 in-in-in SNCiii in-in ActLoopNT-in 2.793 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.18, 63.68 APE9-dihe-in -53.04, 143.19 APE8-dihe-in -78.69, 70.09 APE8-rot-na 32.31 APE67-dihe-in -79.35, -2.96 -56.35, -30.0 APE12-dist-na 14.288 APE11-dist-na 12.111 APE10-dist-na 12.723 APE9-dist-in 7.823 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.25 0.193 0.25 D 302 298 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4e4m TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4E4ME 835 1132 1132.0 0NH:1201 Type1 Active DFGin 6.15 13.969 BLAminus -129.52, -159.3 35.39, 81.53 -94.01, 23.95 298.27, 88.38 -61.49, -26.33 in-in in 8.438 Saltbr-in 2.72 HRD-in -66.9, -47.68 77.51, -1.6 in-in-in SNCiii in-in ActLoopNT-in 2.751 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.74, 130.71 APE9-dihe-in -111.94, 154.92 APE8-dihe-in -81.89, 77.11 APE8-rot-na 32.96 APE67-dihe-in -74.64, -3.77 -64.87, -30.41 APE12-dist-na 13.725 APE11-dist-na 13.029 APE10-dist-na 12.659 APE9-dist-in 7.874 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.25 0.193 0.25 E 302 298 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4e4m TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4GMYA 833 1132 1132.0 0X5:1201 Type1 Active DFGin 6.323 14.368 BLAminus -129.14, -151.03 59.75, 56.19 -91.99, 15.7 291.11, 106.6 -64.82, -18.52 in-in in 8.609 Saltbr-in 2.934 HRD-in -66.28, -44.86 75.83, -6.94 in-in-in SNCiii in-in ActLoopNT-in 2.748 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.06, 153.62 APE9-dihe-in -126.47, 151.79 APE8-dihe-in -73.92, 63.65 APE8-rot-na 25.85 APE67-dihe-in -78.85, -1.67 -58.34, -29.64 APE12-dist-na 13.157 APE11-dist-na 13.07 APE10-dist-na 13.214 APE9-dist-in 7.875 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.403 0.167 0.233 A 302 300 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4gmy TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
8BX6A 840 1132 1132.0 S5I:61201 Type1 Active DFGin 6.252 14.07 BLAminus -127.87, -163.53 51.31, 75.7 -93.06, 21.79 292.47, 95.0 -66.79, -21.79 in-in in 8.305 Saltbr-in 2.845 HRD-in -68.58, -46.29 73.08, -0.73 in-in-in SNCiii in-in ActLoopNT-in 2.803 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.3, 133.56 APE9-dihe-in -112.55, 137.83 APE8-dihe-in -81.04, 71.82 APE8-rot-na 35.5 APE67-dihe-in -78.45, 2.01 -54.32, -34.02 APE12-dist-na 10.6 APE11-dist-na 9.432 APE10-dist-na 10.852 APE9-dist-in 7.383 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.5 0.175 0.202 A 316 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8bx6 TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
8BM2A 840 1132 1132.0 QQC:61201 Type1 Active DFGin 6.495 13.668 BLAminus -136.57, -149.18 56.25, 58.85 -83.86, 18.34 294.62, 85.88 -65.29, -21.3 in-in in 8.604 Saltbr-in 2.709 HRD-in -74.1, -44.85 72.69, -1.57 in-in-in SNCiii in-in ActLoopNT-in 2.805 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.48, 126.84 APE9-dihe-in -115.75, 132.68 APE8-dihe-in -77.01, 74.29 APE8-rot-na 31.66 APE67-dihe-in -77.57, -2.52 -60.5, -31.86 APE12-dist-na 11.43 APE11-dist-na 10.253 APE10-dist-na 10.652 APE9-dist-in 7.29 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.5 0.178 0.202 A 317 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8bm2 TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
8BM2B 840 1132 1132.0 QQC:61201 Type1 Active DFGin 6.444 13.986 BLAminus -119.78, -156.07 50.59, 71.59 -91.98, 24.86 295.0, 85.76 -67.95, -20.12 in-in in 8.7 Saltbr-in 2.9 HRD-in -70.73, -45.45 70.42, 4.42 in-in-in SNCiii in-in ActLoopNT-in 2.821 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.07, 132.24 APE9-dihe-in -113.55, 136.93 APE8-dihe-in -79.1, 74.25 APE8-rot-na 36.64 APE67-dihe-in -79.53, -0.67 -57.94, -30.78 APE12-dist-na 10.834 APE11-dist-na 9.505 APE10-dist-na 11.03 APE9-dist-in 7.25 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.5 0.178 0.202 B 317 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8bm2 TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
5WEVA 833 1130 1132.0 9ZS:1201 Type1 Active DFGin 6.336 14.339 BLAminus -124.44, -159.19 59.63, 63.05 -90.04, 11.06 293.07, 100.36 -64.94, -15.33 in-in in 8.512 Saltbr-in 3.1 HRD-in -69.99, -46.25 71.47, -5.34 in-in-in SNCiii in-in ActLoopNT-in 2.811 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.7, 140.81 APE9-dihe-in -115.07, 150.19 APE8-dihe-in -75.39, 69.78 APE8-rot-na 28.35 APE67-dihe-in -78.28, -1.86 -59.75, -29.31 APE12-dist-na 13.533 APE11-dist-na 13.117 APE10-dist-na 13.038 APE9-dist-in 7.929 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.854 0.167 0.194 A 319 295 3 0 0 0 [[545, 807], [849, 1125]] 2.0 5wev TYR_JAK2-2_HUMAN TYR 3.3e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
2W1IA 843 1132 1132.0 L0I:2133 Type1 Active DFGin 6.093 14.09 BLAminus -142.48, -169.83 51.96, 80.95 -93.55, 29.52 297.23, 91.38 -67.11, -31.24 in-in in 8.397 Saltbr-in 3.063 HRD-in -62.15, -46.21 66.4, 9.56 in-in-in SNCiii in-in ActLoopNT-in 2.678 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -58.29, 137.22 APE9-dihe-in -138.71, 128.52 APE8-dihe-in -70.92, 67.85 APE8-rot-na 29.05 APE67-dihe-in -68.18, -7.39 -56.23, -38.03 APE12-dist-na 10.609 APE11-dist-na 9.405 APE10-dist-na 10.334 APE9-dist-in 6.885 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.6 0.209 0.295 A 326 286 4 0 0 0 [[545, 807], [849, 1125]] 2.0 2w1i TYR_JAK2-2_HUMAN TYR 3.6e-87 298.0 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
5L3AA 841 1130 1132.0 6DP:1201 Type1 Active DFGin 6.364 14.258 BLAminus -128.56, -160.96 38.41, 89.97 -102.03, 29.89 294.5, 81.8 -68.3, -33.79 in-in in 8.624 Saltbr-in 2.634 HRD-in -70.27, -44.2 70.55, -8.67 in-in-in SNCiii in-in ActLoopNT-in 2.668 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.08, 129.72 APE9-dihe-in -120.83, 133.92 APE8-dihe-in -79.34, 75.34 APE8-rot-na 33.39 APE67-dihe-in -79.15, -7.13 -61.09, -27.66 APE12-dist-na 9.341 APE11-dist-na 10.686 APE10-dist-na 11.323 APE9-dist-in 7.795 Y1007F,Y1008F None None XRAY 1.98 0.235 0.277 A 295 290 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5l3a TYR_JAK2-2_HUMAN TYR 4.6e-86 294.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6AAJA 843 1130 1132.0 9T6:1201 Type1 Active DFGin 6.538 14.489 BLAminus -115.63, -164.58 40.59, 91.02 -103.17, 27.63 288.93, 89.27 -64.3, -31.13 in-in in 8.29 Saltbr-in 3.264 HRD-in -73.79, -50.75 76.22, -8.05 in-in-in SNCiii in-in ActLoopNT-in 2.662 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -60.45, 121.7 APE9-dihe-in -116.64, 165.17 APE8-dihe-in -82.47, 75.26 APE8-rot-na 26.67 APE67-dihe-in -77.47, -9.05 -66.38, -30.21 APE12-dist-na 11.304 APE11-dist-na 10.897 APE10-dist-na 12.893 APE9-dist-in 7.857 K943A,K945A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.37 0.211 0.262 A 299 283 5 0 0 0 [[545, 807], [849, 1125]] 2.0 6aaj TYR_JAK2-2_HUMAN TYR 1.1e-86 296.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6AAJB 843 1131 1132.0 9T6:1201 Type1 Active DFGin 6.545 14.395 BLAminus -118.96, -159.53 45.76, 82.33 -100.65, 20.72 287.12, 93.43 -66.06, -21.73 in-in in 8.544 Saltbr-in 2.844 HRD-in -65.44, -45.07 71.55, -13.22 in-in-in SNCiii in-in ActLoopNT-in 2.882 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.56, 105.36 APE9-dihe-in -102.08, 153.39 APE8-dihe-in -76.19, 74.45 APE8-rot-na 31.79 APE67-dihe-in -76.6, 0.02 -66.92, -30.87 APE12-dist-na 999.0 APE11-dist-na 12.177 APE10-dist-na 12.802 APE9-dist-in 7.814 K943A,K945A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.37 0.211 0.262 B 299 274 15 0 0 2 [[545, 807], [849, 1125]] 2.0 6aaj TYR_JAK2-2_HUMAN TYR 1.1e-86 296.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4BBEA 841 1128 1132.0 3O4:2229 Type1 Active DFGin 6.402 14.33 BLAminus -125.98, -167.12 51.58, 81.25 -103.28, 27.34 292.11, 90.95 -69.35, -30.44 in-in in 8.615 Saltbr-in 2.753 HRD-in -62.89, -44.94 65.81, -4.46 in-in-in SNCiii in-in ActLoopNT-in 2.864 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.13, 115.7 APE9-dihe-in -138.06, 143.88 APE8-dihe-in -67.9, 80.65 APE8-rot-na 24.27 APE67-dihe-in -82.38, -6.87 -66.31, -22.61 APE12-dist-na 9.149 APE11-dist-na 12.713 APE10-dist-na 12.214 APE9-dist-in 7.687 D976N None None XRAY 1.9 0.344 0.359 A 298 288 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4bbe TYR_JAK2-2_HUMAN TYR 9.7e-87 296.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4BBEB 841 1128 1132.0 3O4:2229 Type1 Active DFGin 6.205 14.074 BLAminus -127.29, -170.77 54.58, 85.32 -105.55, 29.26 294.25, 89.97 -70.75, -26.52 in-in in 8.621 Saltbr-in 2.769 HRD-in -63.86, -45.65 65.48, -0.2 in-in-in SNCiii in-in ActLoopNT-in 2.964 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -125.21, 122.57 APE9-dihe-in -139.6, 145.84 APE8-dihe-in -69.38, 76.77 APE8-rot-na 24.94 APE67-dihe-in -79.94, -8.57 -65.61, -22.2 APE12-dist-na 10.177 APE11-dist-na 12.651 APE10-dist-na 11.956 APE9-dist-in 7.563 D976N None None XRAY 1.9 0.344 0.359 B 298 288 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4bbe TYR_JAK2-2_HUMAN TYR 9.7e-87 296.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4BBEC 841 1128 1132.0 3O4:2229 Type1 Active DFGin 6.293 14.188 BLAminus -126.43, -167.53 51.59, 82.16 -102.68, 26.48 292.93, 90.3 -68.82, -26.35 in-in in 8.712 Saltbr-in 2.609 HRD-in -65.59, -47.62 66.51, -1.03 in-in-in SNCiii in-in ActLoopNT-in 2.85 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -134.93, 105.75 APE9-dihe-in -133.87, 147.84 APE8-dihe-in -67.78, 81.68 APE8-rot-na 24.27 APE67-dihe-in -82.22, -3.34 -67.19, -22.64 APE12-dist-na 10.312 APE11-dist-na 12.852 APE10-dist-na 12.214 APE9-dist-in 7.68 D976N None None XRAY 1.9 0.344 0.359 C 298 288 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4bbe TYR_JAK2-2_HUMAN TYR 9.7e-87 296.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4BBED 841 1128 1132.0 3O4:2229 Type1 Active DFGin 6.399 14.306 BLAminus -126.45, -167.95 52.52, 81.86 -103.52, 26.55 291.97, 89.91 -69.01, -29.54 in-in in 8.606 Saltbr-in 2.731 HRD-in -63.92, -45.32 65.09, -4.3 in-in-in SNCiii in-in ActLoopNT-in 2.826 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.16, 106.33 APE9-dihe-in -128.2, 144.76 APE8-dihe-in -68.04, 81.17 APE8-rot-na 24.25 APE67-dihe-in -80.48, -9.22 -66.73, -22.27 APE12-dist-na 9.46 APE11-dist-na 12.666 APE10-dist-na 12.359 APE9-dist-in 7.793 D976N None None XRAY 1.9 0.344 0.359 D 298 288 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4bbe TYR_JAK2-2_HUMAN TYR 9.7e-87 296.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4BBFA 841 1128 1132.0 O19:2229 Type1 Active DFGin 6.31 13.682 BLAminus -122.28, 157.21 62.91, 103.68 -120.19, 22.73 295.23, 86.2 -48.8, -35.8 in-in in 8.418 Saltbr-in 2.631 HRD-in -73.08, -45.64 68.9, 4.29 in-in-in SNCiii in-in ActLoopNT-in 2.72 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.01, 125.11 APE9-dihe-in -136.65, 156.16 APE8-dihe-in -79.26, 68.68 APE8-rot-na 35.28 APE67-dihe-in -75.77, -5.49 -52.84, -31.24 APE12-dist-na 9.236 APE11-dist-na 12.578 APE10-dist-na 12.07 APE9-dist-in 7.484 D976N None None XRAY 2.0 0.232 0.289 A 298 288 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4bbf TYR_JAK2-2_HUMAN TYR 9.7e-87 296.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4BBFB 841 1128 1132.0 O19:2229 Type1 Active DFGin 6.579 14.152 BLAminus -105.04, -155.04 19.23, 107.45 -113.45, 24.27 291.25, 95.72 -57.33, -30.87 in-in in 8.405 Saltbr-in 2.719 HRD-in -66.38, -45.27 65.07, 1.26 in-in-in SNCiii in-in ActLoopNT-in 2.739 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -88.58, 126.22 APE9-dihe-in -128.56, 154.33 APE8-dihe-in -77.1, 75.24 APE8-rot-na 35.98 APE67-dihe-in -81.26, -2.64 -63.77, -23.03 APE12-dist-na 8.439 APE11-dist-na 12.975 APE10-dist-na 12.764 APE9-dist-in 7.646 D976N None None XRAY 2.0 0.232 0.289 B 298 288 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4bbf TYR_JAK2-2_HUMAN TYR 9.7e-87 296.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4BBFC 841 1128 1132.0 O19:2229 Type1 Active DFGin 6.539 14.131 BLAminus -104.07, -172.68 36.61, 102.28 -115.67, 23.77 291.54, 96.27 -45.14, -34.47 in-in in 8.461 Saltbr-in 2.759 HRD-in -62.09, -47.1 70.38, 6.53 in-in-in SNCiii in-in ActLoopNT-in 2.702 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -93.18, 129.11 APE9-dihe-in -138.58, 151.05 APE8-dihe-in -77.24, 74.09 APE8-rot-na 32.23 APE67-dihe-in -82.19, -2.12 -57.96, -26.71 APE12-dist-na 9.821 APE11-dist-na 13.104 APE10-dist-na 11.998 APE9-dist-in 7.665 D976N None None XRAY 2.0 0.232 0.289 C 298 288 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4bbf TYR_JAK2-2_HUMAN TYR 9.7e-87 296.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4BBFD 841 1128 1132.0 O19:2229 Type1 Active DFGin 6.286 13.514 BLAminus -118.87, 148.23 73.97, 103.66 -117.83, 24.63 298.53, 82.83 -57.3, -34.26 in-in in 8.351 Saltbr-in 2.67 HRD-in -74.8, -46.04 69.77, 0.83 in-in-in SNCiii in-in ActLoopNT-in 2.741 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.36, 121.84 APE9-dihe-in -135.14, 154.38 APE8-dihe-in -81.18, 76.48 APE8-rot-na 38.95 APE67-dihe-in -79.95, -2.38 -61.79, -29.08 APE12-dist-na 8.023 APE11-dist-na 12.521 APE10-dist-na 11.93 APE9-dist-in 7.383 D976N None None XRAY 2.0 0.232 0.289 D 298 288 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4bbf TYR_JAK2-2_HUMAN TYR 9.7e-87 296.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
5TQ5A 841 1131 1132.0 7GX:4000 Type1.5_Back Active DFGin 7.115 14.952 BLAminus -119.32, -142.58 8.61, 85.15 -90.27, 16.98 285.17, 79.58 -59.76, -25.38 in-in in 8.586 Saltbr-in 2.803 HRD-in -64.66, -52.67 75.62, -9.13 in-in-in SNCiii in-in ActLoopNT-in 2.735 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.04, 123.33 APE9-dihe-in -112.08, 150.1 APE8-dihe-in -79.42, 65.81 APE8-rot-na 31.26 APE67-dihe-in -78.66, 0.06 -53.84, -28.19 APE12-dist-na 10.284 APE11-dist-na 10.931 APE10-dist-na 12.071 APE9-dist-in 7.623 M1073S,F1076T None None XRAY 2.3 0.282 0.332 A 298 291 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5tq5 TYR_JAK2-2_HUMAN TYR 6.1e-87 297.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
5TQ8A 841 1131 1132.0 7GS:4000 Type1.5_Back Active DFGin 6.928 14.98 BLAminus -112.92, -147.32 8.13, 87.34 -90.44, 17.76 279.3, 79.39 -58.24, -25.27 in-in in 8.45 Saltbr-in 2.78 HRD-in -60.77, -51.81 74.15, 1.15 in-in-in SNCiii in-in ActLoopNT-in 2.784 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.68, 127.51 APE9-dihe-in -117.91, 153.17 APE8-dihe-in -80.73, 67.65 APE8-rot-na 28.53 APE67-dihe-in -77.2, -0.13 -49.08, -33.67 APE12-dist-na 9.59 APE11-dist-na 10.322 APE10-dist-na 11.653 APE9-dist-in 7.48 M1073S,F1076T None None XRAY 1.59 0.167 0.192 A 298 291 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5tq8 TYR_JAK2-2_HUMAN TYR 6.1e-87 297.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
7Q7IA 840 1131 1132.0 9I8:4000 Type1.5_Back Active DFGin 6.247 13.731 BLAminus -122.35, -168.71 42.75, 76.87 -84.65, 18.59 291.58, 89.35 -59.24, -27.3 in-in in 8.237 Saltbr-in 2.811 HRD-in -60.05, -48.79 69.76, -14.23 in-in-in SNCiii in-in ActLoopNT-in 2.823 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -62.82, 125.01 APE9-dihe-in -122.77, 133.38 APE8-dihe-in -82.92, 71.36 APE8-rot-na 34.06 APE67-dihe-in -75.58, -1.96 -52.18, -31.93 APE12-dist-na 10.376 APE11-dist-na 9.5 APE10-dist-na 9.908 APE9-dist-in 7.099 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.78 0.189 0.222 A 316 292 0 0 0 0 [[545, 807], [849, 1125]] 2.0 7q7i TYR_JAK2-2_HUMAN TYR 7.6e-87 296.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
7Q7KA 840 1131 1132.0 9I5:4000 Type1.5_Back Active DFGin 6.186 13.705 BLAminus -125.79, -166.32 44.92, 74.69 -86.44, 19.78 289.1, 91.09 -62.55, -24.66 in-in in 8.272 Saltbr-in 2.8 HRD-in -62.94, -47.62 72.62, -19.01 in-in-in SNCiii in-in ActLoopNT-in 2.803 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.24, 127.36 APE9-dihe-in -125.5, 133.64 APE8-dihe-in -82.56, 68.91 APE8-rot-na 32.36 APE67-dihe-in -75.19, -5.67 -51.59, -30.75 APE12-dist-na 10.234 APE11-dist-na 9.45 APE10-dist-na 10.03 APE9-dist-in 7.197 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.61 0.184 0.204 A 316 292 0 0 0 0 [[545, 807], [849, 1125]] 2.0 7q7k TYR_JAK2-2_HUMAN TYR 7.6e-87 296.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
7Q7LA 843 1131 1132.0 9I2:4000 Type1.5_Back Active DFGin 6.309 14.177 BLAminus -119.13, -162.07 32.41, 83.25 -90.84, 16.8 285.63, 88.13 -57.14, -30.61 in-in in 8.319 Saltbr-in 2.795 HRD-in -58.93, -46.4 69.45, -9.97 in-in-in SNCiii in-in ActLoopNT-in 2.796 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.23, 129.86 APE9-dihe-in -123.68, 128.22 APE8-dihe-in -81.04, 69.0 APE8-rot-na 30.72 APE67-dihe-in -77.79, -3.43 -50.71, -28.47 APE12-dist-na 10.666 APE11-dist-na 9.404 APE10-dist-na 9.975 APE9-dist-in 7.117 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.97 0.172 0.196 A 316 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 7q7l TYR_JAK2-2_HUMAN TYR 7.6e-87 296.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
7Q7WA 840 1131 1132.0 9HR:4000 Type1.5_Back Active DFGin 6.41 14.538 BLAminus -113.89, -148.73 11.33, 84.65 -87.0, 16.91 281.85, 82.61 -58.95, -25.64 in-in in 8.333 Saltbr-in 2.795 HRD-in -66.63, -42.74 68.35, -2.19 in-in-in SNCiii in-in ActLoopNT-in 2.789 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -65.94, 122.57 APE9-dihe-in -117.51, 131.31 APE8-dihe-in -82.75, 70.26 APE8-rot-na 32.08 APE67-dihe-in -75.91, -5.95 -51.18, -28.75 APE12-dist-na 10.493 APE11-dist-na 9.493 APE10-dist-na 10.105 APE9-dist-in 6.898 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.85 0.181 0.227 A 316 292 0 0 0 0 [[545, 807], [849, 1125]] 2.0 7q7w TYR_JAK2-2_HUMAN TYR 7.6e-87 296.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
3JY9A 842 1130 1132.0 JZH:1 Type1.5_Back Active DFGin 6.313 14.253 BLAminus -123.65, -154.99 17.68, 87.85 -86.97, 19.54 286.71, 84.2 -50.28, -36.18 in-in in 8.321 Saltbr-in 2.819 HRD-in -57.47, -44.36 69.83, -15.51 in-in-in SNCiii in-in ActLoopNT-in 2.835 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.55, 129.55 APE9-dihe-in -129.25, 135.47 APE8-dihe-in -83.14, 70.63 APE8-rot-na 34.02 APE67-dihe-in -70.23, -8.08 -50.19, -35.53 APE12-dist-na 10.87 APE11-dist-na 9.694 APE10-dist-na 9.976 APE9-dist-in 7.206 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.1 0.201 0.271 A 311 284 5 0 0 0 [[545, 807], [849, 1125]] 2.0 3jy9 TYR_JAK2-2_HUMAN TYR 3e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
3KCKA 842 1130 1132.0 3KC:1 Type1.5_Back Active DFGin 6.245 14.399 BLAminus -122.33, -150.45 29.06, 78.16 -95.54, 2.33 291.6, 90.27 -50.57, -18.29 in-in in 8.364 Saltbr-in 2.926 HRD-in -68.02, -44.9 71.68, -16.29 in-in-in SNCiii in-in ActLoopNT-in 2.715 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -65.17, 121.75 APE9-dihe-in -129.14, 127.5 APE8-dihe-in -83.31, 77.57 APE8-rot-na 25.02 APE67-dihe-in -76.11, -1.18 -59.14, -29.17 APE12-dist-na 11.365 APE11-dist-na 10.127 APE10-dist-na 9.498 APE9-dist-in 7.304 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.2 0.244 0.296 A 313 287 2 0 0 0 [[545, 807], [849, 1125]] 2.0 3kck TYR_JAK2-2_HUMAN TYR 3.1e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
5HEZA 842 1132 1132.0 1M3:1203,1M3:1204 Allosteric,Type1 Inactive DFGin 6.181 13.576 ABAminus -103.67, 3.96 -149.83, 138.2 -131.72, 28.65 300.8, 91.99 -61.15, -26.6 in-in in 8.296 Saltbr-in 2.743 HRD-in -60.6, -48.83 77.58, -20.92 in-in-out SNCiio in-out ActLoopNT-in 2.826 ActLoopCT-out TYR APEdihe_oioao APEdist_aaao APE10-dihe-out -93.22, 48.54 APE9-dihe-in -69.64, 140.78 APE8-dihe-out -72.52, 2.67 APE8-rot-na 25.71 APE67-dihe-out -117.46, -52.02 -67.01, 128.79 APE12-dist-na 14.579 APE11-dist-na 11.317 APE10-dist-na 12.268 APE9-dist-out 8.372 P1057A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.66 0.218 0.238 A 302 289 2 0 0 0 [[545, 807], [849, 1125]] 2.0 5hez TYR_JAK2-2_HUMAN TYR 3.7e-87 297.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
5HEZB 842 1132 1132.0 1M3:1202,1M3:1203 Allosteric,Type1 Inactive DFGin 6.191 13.527 ABAminus -103.41, 2.96 -148.35, 138.17 -130.74, 29.01 299.81, 93.06 -60.8, -25.75 in-in in 8.324 Saltbr-in 2.743 HRD-in -61.03, -48.59 78.08, -21.43 in-in-out SNCiio in-out ActLoopNT-in 2.824 ActLoopCT-out TYR APEdihe_oioao APEdist_aaao APE10-dihe-out 45.93, 11.51 APE9-dihe-in -79.34, 131.16 APE8-dihe-out -79.25, -1.75 APE8-rot-na 28.01 APE67-dihe-out -118.77, -49.59 -69.25, 127.98 APE12-dist-na 12.453 APE11-dist-na 13.412 APE10-dist-na 12.364 APE9-dist-out 8.94 P1057A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.66 0.218 0.238 B 302 291 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5hez TYR_JAK2-2_HUMAN TYR 3.7e-87 297.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
5HEZD 842 1132 1132.0 1M3:1202,1M3:1203 Allosteric,Type1 Inactive DFGin 6.189 13.538 ABAminus -102.35, 3.11 -149.37, 138.24 -132.2, 28.53 300.15, 93.07 -59.55, -26.76 in-in in 8.302 Saltbr-in 2.776 HRD-in -60.7, -48.85 78.34, -23.62 in-in-out SNCiio in-out ActLoopNT-in 2.817 ActLoopCT-out TYR APEdihe_oioao APEdist_aaao APE10-dihe-out -170.07, -9.93 APE9-dihe-in -55.73, 129.12 APE8-dihe-out -79.78, -1.34 APE8-rot-na 27.62 APE67-dihe-out -118.44, -49.74 -68.49, 127.41 APE12-dist-na 10.894 APE11-dist-na 13.836 APE10-dist-na 11.844 APE9-dist-out 8.922 P1057A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.66 0.218 0.238 D 302 291 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5hez TYR_JAK2-2_HUMAN TYR 3.7e-87 297.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
7UYWA 842 1131 1132.0 OV0:1201 Type1 Inactive DFGin 6.162 13.552 ABAminus -102.13, -65.77 -97.61, 118.73 -112.34, 34.06 302.3, 86.62 -68.86, -35.74 in-in in 8.446 Saltbr-in 3.127 HRD-in -63.99, -43.03 64.14, 10.59 in-in-in SNCiii in-in ActLoopNT-in 2.857 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.32, 131.93 APE9-dihe-in -128.43, 132.61 APE8-dihe-in -78.21, 78.3 APE8-rot-na 32.14 APE67-dihe-in -77.48, -5.27 -63.06, -29.41 APE12-dist-na 10.281 APE11-dist-na 9.748 APE10-dist-na 10.244 APE9-dist-in 6.83 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.51 0.21 0.26 A 291 290 0 0 0 0 [[545, 807], [849, 1125]] 2.0 7uyw TYR_JAK2-2_HUMAN TYR 2.3e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6BBVA 843 1131 1132.0 D7D:1201 Type1 Inactive DFGin 6.199 13.255 ABAminus -113.98, 5.62 -153.05, 141.18 -132.03, 30.21 297.46, 84.49 -58.98, -27.69 in-in in 8.296 Saltbr-in 2.796 HRD-in -69.62, -44.96 69.56, -11.16 in-in-in SNCiii in-in ActLoopNT-in 2.782 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -57.98, 116.85 APE9-dihe-in -106.89, 148.6 APE8-dihe-in -82.02, 70.74 APE8-rot-na 31.49 APE67-dihe-in -79.85, -2.28 -54.85, -30.11 APE12-dist-na 13.759 APE11-dist-na 12.417 APE10-dist-na 12.232 APE9-dist-in 7.818 None None None XRAY 1.8 0.178 0.215 A 298 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6bbv TYR_JAK2-2_HUMAN TYR 6.1e-87 297.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6X8EA 843 1130 1132.0 UWP:4000 Type1 Inactive DFGin 6.257 13.614 ABAminus -104.07, -6.27 -144.33, 140.78 -129.93, 25.98 299.29, 84.64 -56.68, -27.83 in-in in 8.514 Saltbr-in 2.77 HRD-in -64.77, -46.55 65.18, -3.57 in-in-none SNCiin in-none ActLoopNT-in 2.871 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.41 APE8-dihe-in -80.26, 70.05 APE8-rot-na 29.9 APE67-dihe-in -75.03, -3.98 -52.38, -33.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.218 M1073S,F1076T PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.75 0.183 0.225 A 298 274 14 0 0 4 [[545, 807], [849, 1125]] 2.0 6x8e TYR_JAK2-2_HUMAN TYR 6.1e-87 297.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6X8EB 843 1132 1132.0 UWP:4001 Type1 Inactive DFGin 6.233 13.721 ABAminus -106.05, -4.78 -145.1, 140.25 -129.47, 26.42 299.09, 84.77 -55.74, -27.96 in-in in 8.485 Saltbr-in 2.791 HRD-in -65.28, -46.37 65.46, -3.84 in-in-none SNCiin in-none ActLoopNT-in 2.89 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.68 APE8-dihe-in -81.95, 68.62 APE8-rot-na 30.25 APE67-dihe-in -74.54, -2.39 -53.13, -32.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.287 M1073S,F1076T PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.75 0.183 0.225 B 298 281 9 0 0 5 [[545, 807], [849, 1125]] 2.0 6x8e TYR_JAK2-2_HUMAN TYR 6.1e-87 297.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
7LL5A 840 1132 1132.0 Y5G:1202 Type1 Inactive DFGin 6.328 13.256 ABAminus -111.9, -9.06 -144.82, 143.7 -137.48, 34.37 299.16, 84.57 -71.01, -21.45 in-in in 8.545 Saltbr-in 2.896 HRD-in -71.87, -45.77 67.74, 6.24 in-in-in SNCiii in-in ActLoopNT-in 2.806 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -50.46, 104.84 APE9-dihe-in -121.67, 111.5 APE8-dihe-in -79.5, 76.19 APE8-rot-na 29.89 APE67-dihe-in -81.17, 1.75 -62.05, -27.41 APE12-dist-na 10.448 APE11-dist-na 9.962 APE10-dist-na 7.596 APE9-dist-in 6.877 None PTR1007 PTR1007 XRAY 1.5 0.196 0.221 A 293 291 2 0 0 0 [[545, 807], [849, 1125]] 2.0 7ll5 TYR_JAK2-2_HUMAN TYR 2.4e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
2B7AA 843 1132 1132.0 IZA:2001 Type1 Inactive DFGin 6.091 13.625 ABAminus -114.38, -2.16 -148.17, 146.16 -136.98, 30.75 299.01, 90.79 -59.91, -29.0 in-in in 8.569 Saltbr-in 2.706 HRD-in -66.9, -48.29 72.12, 2.52 in-in-in SNCiii in-in ActLoopNT-in 2.792 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.58, 136.09 APE9-dihe-in -109.08, 151.35 APE8-dihe-in -75.49, 67.84 APE8-rot-na 28.43 APE67-dihe-in -82.12, -0.33 -57.73, -26.93 APE12-dist-na 12.838 APE11-dist-na 12.784 APE10-dist-na 13.028 APE9-dist-in 7.774 N1129Q PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.0 0.211 0.249 A 293 286 4 0 0 0 [[545, 807], [849, 1125]] 2.0 2b7a TYR_JAK2-2_HUMAN TYR 2.4e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
2B7AB 840 1132 1132.0 IZA:2002 Type1 Inactive DFGin 6.344 13.996 ABAminus -119.31, 4.3 -151.2, 143.13 -134.49, 30.64 293.9, 87.84 -61.34, -27.31 in-in in 8.553 Saltbr-in 2.699 HRD-in -66.93, -45.51 70.91, -4.56 in-in-in SNCiii in-in ActLoopNT-in 2.753 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.16, 133.69 APE9-dihe-in -107.45, 143.93 APE8-dihe-in -73.92, 74.12 APE8-rot-na 26.37 APE67-dihe-in -82.73, -2.12 -60.01, -26.2 APE12-dist-na 12.455 APE11-dist-na 10.818 APE10-dist-na 12.443 APE9-dist-in 7.584 N1129Q PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.0 0.211 0.249 B 293 289 4 0 0 0 [[545, 807], [849, 1125]] 2.0 2b7a TYR_JAK2-2_HUMAN TYR 2.4e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
3FUPA 843 1132 1132.0 MI1:1 Type1 Inactive DFGin 6.225 13.432 ABAminus -116.05, -10.27 -157.31, 141.86 -130.25, 26.52 298.67, 97.27 -56.05, -29.03 in-in in 8.532 Saltbr-in 2.813 HRD-in -69.41, -60.51 90.73, 3.04 in-in-in SNCiii in-in ActLoopNT-in 2.788 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -103.46, 121.61 APE9-dihe-in -101.81, 146.65 APE8-dihe-in -75.99, 69.83 APE8-rot-na 29.05 APE67-dihe-in -81.62, -2.38 -64.51, -21.49 APE12-dist-na 12.388 APE11-dist-na 13.122 APE10-dist-na 12.928 APE9-dist-in 7.819 N1129Q PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.4 0.182 0.25 A 293 286 4 0 0 0 [[545, 807], [849, 1125]] 2.0 3fup TYR_JAK2-2_HUMAN TYR 2.4e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
3FUPB 840 1132 1132.0 MI1:1 Type1 Inactive DFGin 6.516 13.542 ABAminus -123.67, 7.61 -151.78, 141.72 -133.31, 23.64 288.75, 96.19 -52.65, -32.8 in-in in 8.296 Saltbr-in 2.807 HRD-in -70.48, -55.18 91.07, -4.94 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.61, 115.12 APE9-dihe-in -94.97, 142.02 APE8-dihe-in -78.58, 69.75 APE8-rot-na 27.0 APE67-dihe-in -74.68, 0.84 -67.13, -29.65 APE12-dist-na 12.756 APE11-dist-na 12.389 APE10-dist-na 12.223 APE9-dist-in 7.705 N1129Q PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.4 0.182 0.25 B 293 289 4 0 0 0 [[545, 807], [849, 1125]] 2.0 3fup TYR_JAK2-2_HUMAN TYR 2.4e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4P7EA 843 1132 1132.0 2HB:1201 Type1 Inactive DFGin 6.14 13.482 ABAminus -124.45, -1.38 -143.07, 141.76 -136.38, 26.63 297.22, 97.88 -60.6, -28.13 in-in in 8.576 Saltbr-in 2.596 HRD-in -75.55, -47.44 69.37, 3.54 in-in-in SNCiii in-in ActLoopNT-in 2.706 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -104.89, 108.67 APE9-dihe-in -96.54, 141.13 APE8-dihe-in -69.31, 68.63 APE8-rot-na 25.75 APE67-dihe-in -80.27, -1.15 -59.72, -27.17 APE12-dist-na 13.062 APE11-dist-na 13.134 APE10-dist-na 12.609 APE9-dist-in 7.859 N1129Q PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.4 0.208 0.267 A 293 283 7 0 0 0 [[545, 807], [849, 1125]] 2.0 4p7e TYR_JAK2-2_HUMAN TYR 2.4e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4P7EB 840 1132 1132.0 2HB:1201 Type1 Inactive DFGin 6.414 13.697 ABAminus -115.99, -1.13 -148.14, 134.17 -130.43, 26.77 296.67, 85.72 -57.74, -28.02 in-in in 8.328 Saltbr-in 2.808 HRD-in -72.77, -49.08 78.97, -6.71 in-in-in SNCiii in-in ActLoopNT-in 2.724 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.19, 157.28 APE9-dihe-in -129.69, 151.57 APE8-dihe-in -76.37, 70.24 APE8-rot-na 28.33 APE67-dihe-in -83.2, -2.9 -60.49, -24.42 APE12-dist-na 13.343 APE11-dist-na 11.61 APE10-dist-na 12.725 APE9-dist-in 7.656 N1129Q PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.4 0.208 0.267 B 293 287 6 0 0 0 [[545, 807], [849, 1125]] 2.0 4p7e TYR_JAK2-2_HUMAN TYR 2.4e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
3E62A 839 1131 1132.0 5B1:1 Type1 Inactive DFGin 6.204 13.533 ABAminus -117.43, -9.54 -145.14, 143.03 -133.21, 27.96 294.3, 93.66 -64.8, -25.71 in-in in 8.562 Saltbr-in 2.71 HRD-in -66.37, -48.89 71.77, -4.26 in-in-in SNCiii in-in ActLoopNT-in 2.769 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -57.69, 123.41 APE9-dihe-in -119.72, 132.2 APE8-dihe-in -80.32, 68.61 APE8-rot-na 30.21 APE67-dihe-in -75.98, -4.12 -58.29, -27.27 APE12-dist-na 11.194 APE11-dist-na 9.741 APE10-dist-na 10.153 APE9-dist-in 7.058 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.922 0.169 0.218 A 293 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 3e62 TYR_JAK2-2_HUMAN TYR 2.4e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
3E63A 840 1131 1132.0 5B2:1 Type1 Inactive DFGin 6.243 13.507 ABAminus -112.95, -9.31 -145.85, 144.31 -135.9, 32.26 296.11, 93.33 -65.62, -22.76 in-in in 8.52 Saltbr-in 2.697 HRD-in -68.9, -47.56 68.19, -1.26 in-in-in SNCiii in-in ActLoopNT-in 2.732 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -61.25, 121.51 APE9-dihe-in -116.29, 133.15 APE8-dihe-in -81.25, 66.79 APE8-rot-na 26.73 APE67-dihe-in -77.97, -4.82 -56.67, -25.73 APE12-dist-na 11.43 APE11-dist-na 9.917 APE10-dist-na 10.463 APE9-dist-in 7.097 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.9 0.203 0.263 A 293 292 0 0 0 0 [[545, 807], [849, 1125]] 2.0 3e63 TYR_JAK2-2_HUMAN TYR 2.4e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
3E64A 839 1131 1132.0 5B3:1 Type1 Inactive DFGin 6.29 13.426 ABAminus -117.76, -5.87 -147.76, 143.26 -133.0, 28.87 296.92, 93.43 -63.79, -22.59 in-in in 8.54 Saltbr-in 2.695 HRD-in -73.29, -45.29 66.18, -2.15 in-in-in SNCiii in-in ActLoopNT-in 2.766 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -57.84, 124.88 APE9-dihe-in -124.06, 129.84 APE8-dihe-in -80.32, 69.47 APE8-rot-na 30.73 APE67-dihe-in -74.18, -4.27 -57.31, -29.24 APE12-dist-na 11.552 APE11-dist-na 10.057 APE10-dist-na 10.46 APE9-dist-in 7.034 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.8 0.172 0.22 A 293 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 3e64 TYR_JAK2-2_HUMAN TYR 2.4e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
3KRRA 840 1131 1132.0 DQX:60001 Type1 Inactive DFGin 6.111 13.355 ABAminus -118.83, -1.24 -150.38, 145.98 -134.02, 25.36 296.32, 84.62 -62.03, -27.75 in-in in 8.472 Saltbr-in 2.657 HRD-in -68.72, -45.54 74.36, -23.06 in-in-in SNCiii in-in ActLoopNT-in 2.801 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -46.19, 121.88 APE9-dihe-in -140.07, 105.66 APE8-dihe-in -75.55, 70.84 APE8-rot-na 30.39 APE67-dihe-in -77.46, -5.4 -55.44, -28.31 APE12-dist-na 10.213 APE11-dist-na 10.037 APE10-dist-na 7.409 APE9-dist-in 7.271 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.8 0.169 0.206 A 295 292 0 0 0 0 [[545, 807], [849, 1125]] 2.0 3krr TYR_JAK2-2_HUMAN TYR 2.5e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
3LPBA 842 1131 1132.0 NVB:61133 Type1 Inactive DFGin 6.252 13.471 ABAminus -118.13, 3.49 -150.26, 140.34 -128.73, 24.71 296.89, 86.22 -55.47, -30.57 in-in in 8.552 Saltbr-in 2.58 HRD-in -69.29, -46.76 69.54, 5.53 in-in-in SNCiii in-in ActLoopNT-in 2.835 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.85, 115.06 APE9-dihe-in -78.93, 143.76 APE8-dihe-in -77.26, 67.49 APE8-rot-na 32.29 APE67-dihe-in -78.53, -4.63 -55.18, -29.06 APE12-dist-na 12.878 APE11-dist-na 11.685 APE10-dist-na 13.113 APE9-dist-in 7.912 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.0 0.178 0.207 A 295 280 10 0 0 0 [[545, 807], [849, 1125]] 2.0 3lpb TYR_JAK2-2_HUMAN TYR 2.5e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
3LPBB 840 1132 1132.0 NVB:61133 Type1 Inactive DFGin 6.414 13.631 ABAminus -111.19, 1.19 -153.19, 136.07 -126.66, 23.99 296.66, 80.96 -51.9, -31.54 in-in in 8.429 Saltbr-in 2.795 HRD-in -80.7, -45.59 69.18, -7.08 in-in-none SNCiin in-none ActLoopNT-in 2.716 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 123.25 APE9-dihe-in -129.24, 142.1 APE8-dihe-in -77.96, 73.49 APE8-rot-na 29.39 APE67-dihe-in -79.17, -1.43 -62.85, -28.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.981 APE9-dist-in 7.681 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.0 0.178 0.207 B 295 285 8 0 0 3 [[545, 807], [849, 1125]] 2.0 3lpb TYR_JAK2-2_HUMAN TYR 2.5e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
5TQ6A 843 1132 1132.0 7GV:4000 Type1 Inactive DFGin 6.075 13.383 ABAminus -115.84, 4.11 -150.06, 142.11 -129.75, 33.22 297.27, 97.82 -62.11, -22.89 in-in in 8.508 Saltbr-in 2.584 HRD-in -72.1, -52.07 80.22, -10.44 in-in-none SNCiin in-none ActLoopNT-in 2.844 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 149.94 APE9-dihe-in -125.18, 149.33 APE8-dihe-in -73.55, 68.75 APE8-rot-na 30.87 APE67-dihe-in -75.64, -0.92 -63.35, -28.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.055 APE9-dist-in 7.93 M1073S,F1076T PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.06 0.259 0.289 A 304 276 14 0 0 3 [[545, 807], [849, 1125]] 2.0 5tq6 TYR_JAK2-2_HUMAN TYR 6.6e-87 297.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
5TQ6B 843 1130 1132.0 7GV:4001 Type1 Inactive DFGin 6.162 13.363 ABAminus -111.57, -0.99 -147.24, 140.21 -133.48, 34.47 301.56, 87.04 -70.04, -26.0 in-in in 8.402 Saltbr-in 2.86 HRD-in -64.79, -51.16 74.89, -3.31 in-in-none SNCiin in-none ActLoopNT-in 2.684 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.65 APE8-dihe-in -75.33, 63.27 APE8-rot-na 30.25 APE67-dihe-in -71.69, -0.6 -52.05, -37.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.965 M1073S,F1076T PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.06 0.259 0.289 B 304 273 15 0 0 4 [[545, 807], [849, 1125]] 2.0 5tq6 TYR_JAK2-2_HUMAN TYR 6.6e-87 297.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
5TQ7A 841 1132 1132.0 7GT:4000 Type1 Inactive DFGin 6.323 13.447 ABAminus -112.11, 6.39 -155.17, 139.89 -132.33, 31.13 301.67, 84.4 -54.42, -34.31 in-in in 8.227 Saltbr-in 2.596 HRD-in -76.61, -45.66 78.1, -8.67 in-in-none SNCiin in-none ActLoopNT-in 2.861 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 130.6 APE9-dihe-in -120.25, 145.22 APE8-dihe-in -82.11, 80.94 APE8-rot-na 32.95 APE67-dihe-in -75.04, -9.7 -64.29, -26.87 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.422 APE9-dist-in 7.681 M1073S,F1076T,I1126V PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.1 0.229 0.286 A 304 277 15 0 0 4 [[545, 807], [849, 1125]] 2.0 5tq7 TYR_JAK2-2_HUMAN TYR 6.6e-87 297.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
5TQ7B 843 1132 1132.0 7GT:4000 Type1 Inactive DFGin 6.107 13.502 ABAminus -110.47, 5.32 -145.71, 141.14 -137.73, 43.09 299.27, 79.83 -87.98, -15.69 in-in in 8.574 Saltbr-in 2.559 HRD-in -74.7, -41.33 71.59, -12.66 in-in-in SNCiii in-in ActLoopNT-in 2.859 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.68, 157.9 APE9-dihe-in -122.63, 153.25 APE8-dihe-in -77.9, 72.47 APE8-rot-na 30.75 APE67-dihe-in -86.98, 6.22 -56.6, -25.3 APE12-dist-na 999.0 APE11-dist-na 11.751 APE10-dist-na 12.452 APE9-dist-in 7.777 M1073S,F1076T,I1126V PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.1 0.229 0.286 B 304 271 19 0 0 3 [[545, 807], [849, 1125]] 2.0 5tq7 TYR_JAK2-2_HUMAN TYR 6.6e-87 297.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
7LL4A 839 1132 1132.0 Y5D:61201 Type1 Inactive DFGin 6.237 13.346 ABAminus -111.87, -12.4 -148.07, 145.73 -133.69, 26.5 295.72, 88.69 -63.44, -25.93 in-in in 8.56 Saltbr-in 2.871 HRD-in -74.77, -47.27 71.81, 2.5 in-in-in SNCiii in-in ActLoopNT-in 2.805 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.74, 124.43 APE9-dihe-in -118.12, 108.48 APE8-dihe-in -77.72, 77.11 APE8-rot-na 30.86 APE67-dihe-in -76.62, -3.15 -64.49, -27.35 APE12-dist-na 10.187 APE11-dist-na 8.934 APE10-dist-na 8.329 APE9-dist-in 7.019 None PTR1007 PTR1007 XRAY 1.31 0.178 0.194 A 297 294 0 0 0 0 [[545, 807], [849, 1125]] 2.0 7ll4 TYR_JAK2-2_HUMAN TYR 2.5e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
7REEA 839 1130 1132.0 4LY:61201 Type1 Inactive DFGin 6.288 13.336 ABAminus -111.29, -12.64 -147.41, 147.89 -137.15, 27.39 297.98, 85.55 -64.9, -23.25 in-in in 8.492 Saltbr-in 2.787 HRD-in -71.82, -48.68 71.66, 2.81 in-in-none SNCiin in-none ActLoopNT-in 2.809 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 113.93 APE8-dihe-in -75.76, 74.26 APE8-rot-na 30.49 APE67-dihe-in -80.67, 1.45 -60.2, -27.42 APE12-dist-na 11.193 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.133 None PTR1007 PTR1007 XRAY 1.38 0.174 0.205 A 297 288 4 0 0 2 [[545, 807], [849, 1125]] 2.0 7ree TYR_JAK2-2_HUMAN TYR 2.5e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4D0WA 839 1130 1132.0 VVQ:2132 Type1 Inactive DFGin 6.276 13.526 ABAminus -121.35, -5.98 -149.17, 146.15 -130.76, 29.34 294.02, 83.91 -68.32, -23.85 in-in in 8.427 Saltbr-in 2.822 HRD-in -68.34, -43.76 72.13, -8.84 in-in-in SNCiii in-in ActLoopNT-in 2.83 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.76, 138.61 APE9-dihe-in -136.68, 129.14 APE8-dihe-in -86.53, 73.15 APE8-rot-na 31.27 APE67-dihe-in -71.04, -8.89 -58.05, -27.58 APE12-dist-na 10.91 APE11-dist-na 9.679 APE10-dist-na 10.123 APE9-dist-in 7.038 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.77 0.175 0.215 A 298 291 1 0 0 0 [[545, 807], [849, 1125]] 2.0 4d0w TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4D0XA 839 1131 1132.0 953:2132 Type1 Inactive DFGin 6.176 13.315 ABAminus -120.48, -3.08 -149.35, 141.94 -130.69, 26.8 296.75, 85.48 -62.08, -25.74 in-in in 8.515 Saltbr-in 2.737 HRD-in -69.4, -46.22 76.98, -14.46 in-in-in SNCiii in-in ActLoopNT-in 2.83 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -45.33, 128.51 APE9-dihe-in -145.08, 109.4 APE8-dihe-in -86.52, 75.6 APE8-rot-na 31.86 APE67-dihe-in -75.53, -7.86 -59.36, -25.54 APE12-dist-na 10.423 APE11-dist-na 9.495 APE10-dist-na 7.147 APE9-dist-in 6.946 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.82 0.166 0.219 A 298 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4d0x TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
5AEPA 840 1131 1132.0 QUP:2000 Type1 Inactive DFGin 6.253 13.159 ABAminus -125.75, 4.32 -152.04, 146.73 -136.98, 29.7 294.69, 83.13 -68.44, -27.57 in-in in 8.435 Saltbr-in 2.848 HRD-in -64.03, -50.14 76.8, -15.41 in-in-in SNCiii in-in ActLoopNT-in 2.708 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -42.38, 127.98 APE9-dihe-in -145.32, 108.79 APE8-dihe-in -83.74, 73.12 APE8-rot-na 22.99 APE67-dihe-in -68.58, -7.69 -60.86, -27.68 APE12-dist-na 10.399 APE11-dist-na 9.306 APE10-dist-na 7.369 APE9-dist-in 7.021 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.95 0.173 0.213 A 298 289 3 0 0 0 [[545, 807], [849, 1125]] 2.0 5aep TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
3TJCA 843 1132 1132.0 0TP:1 Type1 Inactive DFGin 6.182 13.776 ABAminus -111.28, 8.43 -150.47, 142.92 -136.09, 31.13 297.77, 93.1 -58.92, -26.75 in-in in 8.633 Saltbr-in 2.701 HRD-in -58.35, -49.6 68.34, 2.22 in-in-in SNCiii in-in ActLoopNT-in 2.807 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.05, 136.72 APE9-dihe-in -111.73, 151.95 APE8-dihe-in -78.69, 64.15 APE8-rot-na 33.68 APE67-dihe-in -82.41, 8.52 -50.91, -27.5 APE12-dist-na 12.872 APE11-dist-na 12.665 APE10-dist-na 13.033 APE9-dist-in 7.847 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.4 0.265 0.275 A 298 286 4 0 0 0 [[545, 807], [849, 1125]] 2.0 3tjc TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
3TJCB 840 1132 1132.0 0TP:1 Type1 Inactive DFGin 6.383 14.126 ABAminus -116.85, 12.84 -151.32, 140.31 -135.01, 33.47 291.72, 91.04 -63.92, -25.01 in-in in 8.469 Saltbr-in 2.761 HRD-in -67.53, -45.4 67.54, -5.76 in-in-in SNCiii in-in ActLoopNT-in 2.726 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.38, 138.96 APE9-dihe-in -114.25, 144.01 APE8-dihe-in -76.43, 71.46 APE8-rot-na 32.78 APE67-dihe-in -82.33, 3.33 -53.44, -26.31 APE12-dist-na 12.464 APE11-dist-na 10.827 APE10-dist-na 12.41 APE9-dist-in 7.632 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.4 0.265 0.275 B 298 289 4 0 0 0 [[545, 807], [849, 1125]] 2.0 3tjc TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
3TJDA 843 1132 1132.0 6TP:1 Type1 Inactive DFGin 5.991 13.668 ABAminus -106.4, 6.86 -148.97, 135.33 -126.71, 31.52 298.26, 96.91 -65.03, -17.37 in-in in 8.661 Saltbr-in 2.405 HRD-in -60.32, -42.09 57.24, 2.17 in-in-in SNCiii in-in ActLoopNT-in 2.756 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.99, 136.33 APE9-dihe-in -114.67, 153.5 APE8-dihe-in -80.71, 62.46 APE8-rot-na 37.92 APE67-dihe-in -72.13, 9.26 -46.3, -36.88 APE12-dist-na 12.873 APE11-dist-na 12.766 APE10-dist-na 12.946 APE9-dist-in 7.834 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.9 0.286 0.312 A 298 286 4 0 0 0 [[545, 807], [849, 1125]] 2.0 3tjd TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
3TJDB 840 1132 1132.0 6TP:1 Type1 Inactive DFGin 6.389 13.998 ABAminus -115.4, 19.45 -153.78, 133.17 -126.99, 29.7 296.86, 92.39 -60.7, -23.46 in-in in 8.472 Saltbr-in 2.899 HRD-in -70.92, -38.15 64.72, -21.56 in-in-in SNCiii in-in ActLoopNT-in 2.808 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -58.27, 138.19 APE9-dihe-in -112.71, 149.09 APE8-dihe-in -82.04, 69.58 APE8-rot-na 37.61 APE67-dihe-in -79.66, -3.25 -52.11, -26.43 APE12-dist-na 12.399 APE11-dist-na 10.691 APE10-dist-na 12.313 APE9-dist-in 7.826 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.9 0.286 0.312 B 298 289 4 0 0 0 [[545, 807], [849, 1125]] 2.0 3tjd TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4HGEA 843 1132 1132.0 15V:1201 Type1 Inactive DFGin 6.12 13.322 ABAminus -121.19, -0.59 -151.44, 140.08 -132.37, 31.16 296.92, 93.91 -59.01, -29.78 in-in in 8.51 Saltbr-in 2.651 HRD-in -71.02, -46.89 72.34, 4.2 in-in-in SNCiii in-in ActLoopNT-in 2.816 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.36, 116.11 APE9-dihe-in -94.64, 140.5 APE8-dihe-in -78.26, 68.86 APE8-rot-na 33.18 APE67-dihe-in -79.92, -6.13 -58.48, -24.37 APE12-dist-na 13.133 APE11-dist-na 12.335 APE10-dist-na 12.614 APE9-dist-in 7.9 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.3 0.182 0.227 A 300 286 4 0 0 0 [[545, 807], [849, 1125]] 2.0 4hge TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4HGEB 839 1132 1132.0 15V:1201 Type1 Inactive DFGin 6.414 13.619 ABAminus -123.27, 3.39 -144.34, 141.84 -131.47, 30.21 289.8, 89.09 -61.76, -21.14 in-in in 8.47 Saltbr-in 2.755 HRD-in -75.48, -44.42 74.95, -13.38 in-in-in SNCiii in-in ActLoopNT-in 2.775 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -80.96, 159.38 APE9-dihe-in -121.56, 128.25 APE8-dihe-in -83.16, 76.08 APE8-rot-na 32.14 APE67-dihe-in -81.69, -3.64 -63.01, -27.28 APE12-dist-na 7.612 APE11-dist-na 9.196 APE10-dist-na 10.927 APE9-dist-in 7.57 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.3 0.182 0.227 B 300 290 4 0 0 0 [[545, 807], [849, 1125]] 2.0 4hge TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4IVAA 841 1132 1132.0 1J5:1201 Type1 Inactive DFGin 6.388 13.602 ABAminus -118.25, 0.69 -152.6, 145.56 -135.74, 29.43 296.04, 91.26 -62.02, -26.49 in-in in 8.14 Saltbr-in 2.66 HRD-in -71.64, -46.05 71.97, 4.91 in-in-in SNCiii in-in ActLoopNT-in 2.828 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.88, 157.47 APE9-dihe-in -148.23, 152.2 APE8-dihe-in -79.45, 71.02 APE8-rot-na 33.72 APE67-dihe-in -79.14, -1.96 -60.0, -26.54 APE12-dist-na 13.969 APE11-dist-na 13.082 APE10-dist-na 12.805 APE9-dist-in 7.824 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.5 0.176 0.193 A 300 292 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4iva TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4JI9A 843 1132 1132.0 1M3:1201 Type1 Inactive DFGin 6.324 13.484 ABAminus -109.55, -7.44 -150.82, 140.52 -127.26, 30.44 299.13, 87.76 -52.84, -40.14 in-in in 8.585 Saltbr-in 2.647 HRD-in -80.17, -42.61 76.43, -32.58 in-in-out SNCiio in-out ActLoopNT-in 2.752 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -82.23, 111.22 APE9-dihe-in -100.97, 137.91 APE8-dihe-in -72.06, 68.6 APE8-rot-na 27.55 APE67-dihe-in -77.94, 0.46 -63.88, -26.22 APE12-dist-na 13.441 APE11-dist-na 13.317 APE10-dist-na 13.32 APE9-dist-out 8.757 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.4 0.203 0.245 A 300 286 4 0 0 0 [[545, 807], [849, 1125]] 2.0 4ji9 TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4JI9B 839 1132 1132.0 1M3:1201 Type1 Inactive DFGin 6.466 13.849 ABAminus -116.52, -6.78 -147.24, 138.79 -124.56, 33.92 292.32, 86.1 -62.37, -34.07 in-in in 8.491 Saltbr-in 2.822 HRD-in -81.25, -47.33 75.7, -23.37 in-in-in SNCiii in-in ActLoopNT-in 2.697 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.22, 150.08 APE9-dihe-in -122.92, 128.48 APE8-dihe-in -79.58, 77.7 APE8-rot-na 25.7 APE67-dihe-in -82.32, 3.2 -61.18, -27.11 APE12-dist-na 8.057 APE11-dist-na 10.455 APE10-dist-na 11.075 APE9-dist-in 7.698 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.4 0.203 0.245 B 300 290 4 0 0 0 [[545, 807], [849, 1125]] 2.0 4ji9 TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
3Q32A 840 1132 1132.0 J2I:60001 Type1 Inactive DFGin 6.361 13.16 ABAminus -114.0, 9.8 -155.91, 140.25 -131.27, 26.73 299.78, 91.25 -53.97, -36.83 in-in in 8.507 Saltbr-in 2.734 HRD-in -67.89, -51.07 72.0, 2.71 in-in-in SNCiii in-in ActLoopNT-in 2.672 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.02, 124.49 APE9-dihe-in -104.36, 146.31 APE8-dihe-in -75.92, 65.47 APE8-rot-na 28.37 APE67-dihe-in -65.9, -9.93 -48.92, -44.51 APE12-dist-na 13.055 APE11-dist-na 12.866 APE10-dist-na 13.129 APE9-dist-in 7.929 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.5 0.178 0.21 A 301 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 3q32 TYR_JAK2-2_HUMAN TYR 2.7e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
3Q32B 839 1132 1132.0 J2I:60002 Type1 Inactive DFGin 6.567 13.418 ABAminus -99.13, -6.07 -150.2, 138.61 -127.33, 32.33 296.64, 91.2 -58.16, -35.1 in-in in 8.333 Saltbr-in 3.028 HRD-in -64.89, -50.46 73.01, -21.55 in-in-out SNCiio in-out ActLoopNT-in 2.727 ActLoopCT-out TYR APEdihe_ooiai APEdist_aaai APE10-dihe-out 54.05, -68.26 APE9-dihe-out 64.56, 127.18 APE8-dihe-in -78.63, 72.28 APE8-rot-na 27.75 APE67-dihe-in -79.48, -5.64 -54.11, -32.33 APE12-dist-na 10.429 APE11-dist-na 10.277 APE10-dist-na 11.348 APE9-dist-in 7.501 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.5 0.178 0.21 B 301 294 0 0 0 0 [[545, 807], [849, 1125]] 2.0 3q32 TYR_JAK2-2_HUMAN TYR 2.7e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
5CF8A 842 1132 1132.0 50V:64000 Type1 Inactive DFGin 6.319 13.61 ABAminus -111.5, 5.34 -159.98, 145.11 -133.05, 28.13 292.06, 92.11 -55.99, -28.41 in-in in 8.519 Saltbr-in 2.699 HRD-in -68.8, -45.07 66.6, 4.57 in-in-in SNCiii in-in ActLoopNT-in 2.807 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -84.77, 124.44 APE9-dihe-in -93.29, 144.71 APE8-dihe-in -78.53, 70.36 APE8-rot-na 30.49 APE67-dihe-in -76.87, -0.84 -55.83, -30.99 APE12-dist-na 12.946 APE11-dist-na 11.773 APE10-dist-na 12.808 APE9-dist-in 7.75 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.8 0.191 0.204 A 301 286 5 0 0 0 [[545, 807], [849, 1125]] 2.0 5cf8 TYR_JAK2-2_HUMAN TYR 2.7e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
5CF8B 839 1132 1132.0 50V:64000 Type1 Inactive DFGin 6.435 13.692 ABAminus -110.5, 4.8 -158.24, 144.72 -132.59, 27.56 291.52, 92.27 -58.53, -26.74 in-in in 8.453 Saltbr-in 2.731 HRD-in -69.62, -45.44 67.63, 3.37 in-in-out SNCiio in-out ActLoopNT-in 2.808 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 60.73, 91.69 APE9-dihe-in -118.13, 144.09 APE8-dihe-in -78.0, 69.71 APE8-rot-na 28.79 APE67-dihe-in -78.53, -1.18 -55.41, -30.41 APE12-dist-na 10.287 APE11-dist-na 11.081 APE10-dist-na 11.869 APE9-dist-in 7.744 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.8 0.191 0.204 B 301 289 5 0 0 0 [[545, 807], [849, 1125]] 2.0 5cf8 TYR_JAK2-2_HUMAN TYR 2.7e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4AQCA 842 1132 1132.0 88A:2001 Type1 Inactive DFGin 6.15 13.455 ABAminus -119.36, 0.46 -148.42, 139.35 -130.52, 29.8 295.81, 93.68 -57.31, -31.29 in-in in 8.588 Saltbr-in 2.64 HRD-in -68.43, -50.02 76.23, -1.23 in-in-in SNCiii in-in ActLoopNT-in 2.76 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.9, 129.7 APE9-dihe-in -107.31, 146.17 APE8-dihe-in -74.14, 67.42 APE8-rot-na 34.69 APE67-dihe-in -82.32, -4.12 -58.66, -24.6 APE12-dist-na 12.744 APE11-dist-na 12.838 APE10-dist-na 12.962 APE9-dist-in 7.816 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.9 0.178 0.217 A 301 291 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4aqc TYR_JAK2-2_HUMAN TYR 2.7e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4AQCB 836 1132 1132.0 88A:2001 Type1 Inactive DFGin 6.388 13.689 ABAminus -123.9, -2.65 -148.48, 139.47 -132.14, 28.65 294.89, 80.58 -66.71, -20.79 in-in in 8.457 Saltbr-in 2.638 HRD-in -71.57, -47.61 74.96, -4.96 in-in-in SNCiii in-in ActLoopNT-in 2.744 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.78, 150.42 APE9-dihe-in -118.99, 125.24 APE8-dihe-in -80.6, 74.92 APE8-rot-na 32.88 APE67-dihe-in -80.42, -6.59 -61.14, -25.41 APE12-dist-na 7.979 APE11-dist-na 9.467 APE10-dist-na 10.907 APE9-dist-in 7.626 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.9 0.178 0.217 B 301 297 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4aqc TYR_JAK2-2_HUMAN TYR 2.7e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4F08A 843 1132 1132.0 1RS:1201 Type1 Inactive DFGin 6.422 13.449 ABAminus -118.75, 17.84 -162.68, 140.07 -138.8, 36.17 302.12, 78.28 -60.82, -32.25 in-in in 8.347 Saltbr-in 2.96 HRD-in -65.4, -47.08 70.33, 4.13 in-in-in SNCiii in-in ActLoopNT-in 2.716 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.27, 131.17 APE9-dihe-in -120.61, 142.32 APE8-dihe-in -71.84, 61.3 APE8-rot-na 27.63 APE67-dihe-in -74.77, -5.24 -55.3, -29.19 APE12-dist-na 12.333 APE11-dist-na 13.397 APE10-dist-na 12.857 APE9-dist-in 7.956 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.82 0.214 0.241 A 302 290 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4f08 TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4F08B 843 1132 1132.0 1RS:1201 Type1 Inactive DFGin 6.516 13.42 ABAminus -124.31, 17.64 -159.69, 141.63 -138.77, 37.19 300.52, 77.4 -63.7, -27.82 in-in in 8.334 Saltbr-in 2.917 HRD-in -64.42, -45.84 68.41, 15.3 in-in-in SNCiii in-in ActLoopNT-in 2.724 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -58.79, 144.81 APE9-dihe-in -113.89, 127.58 APE8-dihe-in -71.3, 63.33 APE8-rot-na 27.17 APE67-dihe-in -75.09, -5.44 -57.05, -30.14 APE12-dist-na 8.12 APE11-dist-na 9.253 APE10-dist-na 11.287 APE9-dist-in 7.932 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.82 0.214 0.241 B 302 290 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4f08 TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4F09A 843 1132 1132.0 JAK:1201 Type1 Inactive DFGin 6.346 13.64 ABAminus -102.4, 3.93 -153.26, 137.83 -131.35, 32.59 302.39, 88.52 -60.65, -32.63 in-in in 8.192 Saltbr-in 2.72 HRD-in -66.03, -47.09 70.26, -3.17 in-in-in SNCiii in-in ActLoopNT-in 2.659 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.49, 147.17 APE9-dihe-in -131.9, 144.19 APE8-dihe-in -76.78, 68.09 APE8-rot-na 28.11 APE67-dihe-in -65.65, -9.03 -42.52, -43.38 APE12-dist-na 13.863 APE11-dist-na 13.083 APE10-dist-na 12.641 APE9-dist-in 7.809 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.4 0.198 0.254 A 302 290 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4f09 TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4GFMA 840 1130 1132.0 0X2:1201 Type1 Inactive DFGin 6.218 13.617 ABAminus -121.44, -7.12 -143.9, 139.81 -132.81, 29.99 295.23, 86.37 -67.0, -21.6 in-in in 8.42 Saltbr-in 3.064 HRD-in -69.73, -44.15 65.44, -8.11 in-in-in SNCiii in-in ActLoopNT-in 2.718 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.82, 128.5 APE9-dihe-in -126.85, 127.41 APE8-dihe-in -79.98, 73.49 APE8-rot-na 29.58 APE67-dihe-in -75.78, -2.18 -60.58, -27.16 APE12-dist-na 10.952 APE11-dist-na 9.716 APE10-dist-na 9.927 APE9-dist-in 7.029 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.3 0.171 0.242 A 302 291 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4gfm TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
3RVGA 841 1132 1132.0 17P:2000 Type1 Inactive DFGin 6.444 13.309 ABAminus -117.6, -0.24 -150.28, 146.04 -143.43, 33.28 298.77, 92.11 -68.51, -23.75 in-in in 8.454 Saltbr-in 2.496 HRD-in -62.82, -53.33 76.84, -7.61 in-in-none SNCiin in-none ActLoopNT-in 2.733 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -151.78 APE8-dihe-in -87.41, 90.65 APE8-rot-na 40.72 APE67-dihe-in -82.3, 0.9 -69.11, -22.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.738 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.498 0.225 0.3 A 303 287 5 0 0 5 [[545, 807], [849, 1125]] 2.0 3rvg TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VGLA 840 1132 1132.0 RXT:61201 Type1 Inactive DFGin 6.446 13.513 ABAminus -117.0, -7.21 -146.07, 141.05 -130.49, 28.54 292.94, 81.12 -65.56, -22.11 in-in in 8.428 Saltbr-in 2.754 HRD-in -71.73, -48.4 73.96, -1.64 in-in-in SNCiii in-in ActLoopNT-in 2.781 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -88.11, 129.62 APE9-dihe-in -121.72, 122.37 APE8-dihe-in -84.02, 76.32 APE8-rot-na 33.09 APE67-dihe-in -78.28, -3.75 -61.51, -29.27 APE12-dist-na 13.555 APE11-dist-na 9.49 APE10-dist-na 8.47 APE9-dist-in 7.051 None PTR1007 PTR1007 XRAY 1.9 0.182 0.217 A 308 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vgl TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VGLB 840 1132 1132.0 RXT:61201 Type1 Inactive DFGin 6.445 13.616 ABAminus -116.85, -7.44 -149.05, 140.79 -130.84, 27.89 290.32, 82.4 -67.42, -21.82 in-in in 8.398 Saltbr-in 2.781 HRD-in -71.23, -46.75 71.83, -3.65 in-in-in SNCiii in-in ActLoopNT-in 2.815 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -93.23, 146.01 APE9-dihe-in -126.07, 123.7 APE8-dihe-in -81.61, 74.86 APE8-rot-na 31.65 APE67-dihe-in -77.61, -3.9 -60.75, -30.09 APE12-dist-na 13.288 APE11-dist-na 9.377 APE10-dist-na 8.665 APE9-dist-in 6.981 None PTR1007 PTR1007 XRAY 1.9 0.182 0.217 B 308 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vgl TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VGLC 843 1131 1132.0 RXT:61201 Type1 Inactive DFGin 6.222 13.379 ABAminus -115.55, -9.12 -143.9, 140.61 -132.23, 26.54 293.7, 85.16 -65.11, -21.72 in-in in 8.417 Saltbr-in 2.704 HRD-in -73.34, -48.11 71.88, -3.21 in-in-in SNCiii in-in ActLoopNT-in 2.813 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.66, 127.53 APE9-dihe-in -113.0, 141.05 APE8-dihe-in -75.8, 72.0 APE8-rot-na 32.54 APE67-dihe-in -77.35, -4.0 -61.49, -27.59 APE12-dist-na 13.338 APE11-dist-na 13.082 APE10-dist-na 13.222 APE9-dist-in 7.904 None PTR1007 PTR1007 XRAY 1.9 0.182 0.217 C 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vgl TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VGLD 843 1131 1132.0 RXT:61201 Type1 Inactive DFGin 6.288 13.488 ABAminus -116.23, -6.92 -148.77, 141.37 -133.22, 26.24 295.62, 83.68 -64.72, -19.37 in-in in 8.434 Saltbr-in 2.677 HRD-in -70.05, -46.57 72.2, -0.79 in-in-in SNCiii in-in ActLoopNT-in 2.763 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.83, 129.61 APE9-dihe-in -113.86, 144.08 APE8-dihe-in -77.54, 74.01 APE8-rot-na 34.3 APE67-dihe-in -79.99, -2.4 -62.52, -26.5 APE12-dist-na 13.31 APE11-dist-na 13.261 APE10-dist-na 13.273 APE9-dist-in 7.82 None PTR1007 PTR1007 XRAY 1.9 0.182 0.217 D 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vgl TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VN8A 840 1132 1132.0 3JW:61201 Type1 Inactive DFGin 6.42 13.799 ABAminus -116.88, -11.5 -143.58, 137.54 -129.5, 26.21 292.83, 83.89 -62.24, -22.44 in-in in 8.581 Saltbr-in 2.751 HRD-in -74.45, -48.89 74.52, -4.46 in-in-in SNCiii in-in ActLoopNT-in 2.788 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.86, 136.24 APE9-dihe-in -126.34, 122.3 APE8-dihe-in -79.17, 73.44 APE8-rot-na 30.57 APE67-dihe-in -82.31, 0.54 -60.95, -23.7 APE12-dist-na 13.292 APE11-dist-na 9.326 APE10-dist-na 8.777 APE9-dist-in 6.956 None PTR1007 PTR1007 XRAY 1.9 0.185 0.215 A 308 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vn8 TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VN8B 843 1131 1132.0 3JW:61201 Type1 Inactive DFGin 6.202 13.633 ABAminus -114.34, -11.39 -144.21, 140.62 -131.03, 26.72 294.72, 85.25 -60.7, -25.73 in-in in 8.616 Saltbr-in 2.632 HRD-in -74.15, -47.61 71.7, -1.3 in-in-in SNCiii in-in ActLoopNT-in 2.769 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.46, 140.77 APE9-dihe-in -119.45, 142.72 APE8-dihe-in -71.39, 69.25 APE8-rot-na 31.65 APE67-dihe-in -81.85, -1.4 -64.46, -21.62 APE12-dist-na 13.405 APE11-dist-na 12.858 APE10-dist-na 13.328 APE9-dist-in 7.896 None PTR1007 PTR1007 XRAY 1.9 0.185 0.215 B 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vn8 TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VNBA 840 1132 1132.0 R6P:61201 Type1 Inactive DFGin 6.35 13.558 ABAminus -118.62, -19.62 -134.83, 143.12 -133.38, 24.47 298.28, 91.33 -62.05, -22.2 in-in in 8.704 Saltbr-in 3.038 HRD-in -74.06, -49.4 74.99, -5.13 in-in-in SNCiii in-in ActLoopNT-in 2.777 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.81, 144.4 APE9-dihe-in -128.3, 128.29 APE8-dihe-in -78.46, 78.55 APE8-rot-na 29.64 APE67-dihe-in -84.54, -4.75 -64.16, -21.71 APE12-dist-na 13.155 APE11-dist-na 9.378 APE10-dist-na 9.993 APE9-dist-in 6.925 None PTR1007 PTR1007 XRAY 2.19 0.217 0.261 A 308 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnb TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VNBB 843 1131 1132.0 R6P:61201 Type1 Inactive DFGin 6.151 13.517 ABAminus -116.85, -18.84 -135.3, 144.45 -134.76, 23.18 296.23, 88.9 -62.89, -23.75 in-in in 8.742 Saltbr-in 2.835 HRD-in -73.15, -47.55 74.78, -6.06 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.7, 141.71 APE9-dihe-in -125.69, 135.6 APE8-dihe-in -71.63, 74.77 APE8-rot-na 30.51 APE67-dihe-in -85.73, -5.2 -67.19, -19.79 APE12-dist-na 13.148 APE11-dist-na 12.045 APE10-dist-na 12.948 APE9-dist-in 7.869 None PTR1007 PTR1007 XRAY 2.19 0.217 0.261 B 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnb TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VNCA 840 1131 1132.0 R6V:61201 Type1 Inactive DFGin 6.175 13.178 ABAminus -125.0, 1.92 -144.44, 138.94 -134.55, 26.62 299.16, 82.3 -63.96, -13.53 in-in in 8.732 Saltbr-in 3.231 HRD-in -71.26, -46.55 70.57, -1.02 in-in-in SNCiii in-in ActLoopNT-in 2.753 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.44, 156.2 APE9-dihe-in -132.4, 123.78 APE8-dihe-in -79.65, 76.35 APE8-rot-na 29.35 APE67-dihe-in -79.45, -6.71 -61.99, -27.52 APE12-dist-na 12.877 APE11-dist-na 8.486 APE10-dist-na 9.116 APE9-dist-in 6.852 None PTR1007 PTR1007 XRAY 2.3 0.227 0.269 A 308 292 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnc TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VNCB 843 1131 1132.0 R6V:61201 Type1 Inactive DFGin 6.154 13.17 ABAminus -122.12, 1.77 -145.07, 140.87 -135.43, 27.24 299.55, 83.32 -63.99, -17.1 in-in in 8.871 Saltbr-in 2.922 HRD-in -71.34, -45.2 70.18, -2.12 in-in-in SNCiii in-in ActLoopNT-in 2.751 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.37, 171.08 APE9-dihe-in -127.34, 149.39 APE8-dihe-in -72.05, 74.05 APE8-rot-na 32.11 APE67-dihe-in -79.07, -5.61 -65.16, -22.9 APE12-dist-na 12.808 APE11-dist-na 12.821 APE10-dist-na 13.914 APE9-dist-in 7.934 None PTR1007 PTR1007 XRAY 2.3 0.227 0.269 B 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnc TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VNEA 840 1131 1132.0 2TA:1201 Type1 Inactive DFGin 6.24 13.55 ABAminus -112.42, -11.2 -144.98, 141.53 -127.78, 32.23 299.17, 89.49 -63.48, -25.65 in-in in 8.665 Saltbr-in 3.036 HRD-in -73.58, -49.14 71.52, -8.03 in-in-in SNCiii in-in ActLoopNT-in 2.828 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.09, 122.45 APE9-dihe-in -105.67, 157.15 APE8-dihe-in -76.97, 84.95 APE8-rot-na 28.57 APE67-dihe-in -90.04, 0.84 -78.4, -8.76 APE12-dist-na 9.559 APE11-dist-na 10.649 APE10-dist-na 13.363 APE9-dist-in 7.541 None PTR1007 PTR1007 XRAY 2.32 0.218 0.256 A 308 292 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vne TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VNEB 843 1131 1132.0 2TA:1201 Type1 Inactive DFGin 6.117 13.225 ABAminus -110.41, -14.18 -143.68, 142.64 -126.91, 32.7 300.48, 90.31 -63.79, -30.1 in-in in 8.677 Saltbr-in 2.484 HRD-in -71.56, -46.99 72.0, -8.33 in-in-out SNCiio in-out ActLoopNT-in 2.815 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -93.72, 133.02 APE9-dihe-in -103.49, 156.39 APE8-dihe-in -78.16, 83.6 APE8-rot-na 32.04 APE67-dihe-in -91.27, 0.43 -78.58, -6.63 APE12-dist-na 13.225 APE11-dist-na 13.061 APE10-dist-na 14.217 APE9-dist-out 8.301 None PTR1007 PTR1007 XRAY 2.32 0.218 0.256 B 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vne TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VNFA 840 1132 1132.0 R6S:61201 Type1 Inactive DFGin 6.401 13.602 ABAminus -118.43, -3.64 -151.35, 141.65 -132.21, 29.14 295.59, 85.58 -63.11, -24.0 in-in in 8.575 Saltbr-in 2.971 HRD-in -72.52, -45.08 76.22, -28.49 in-in-in SNCiii in-in ActLoopNT-in 2.846 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.59, 126.97 APE9-dihe-in -119.09, 117.22 APE8-dihe-in -78.88, 74.74 APE8-rot-na 28.3 APE67-dihe-in -82.18, -0.54 -60.56, -26.17 APE12-dist-na 13.628 APE11-dist-na 9.993 APE10-dist-na 8.563 APE9-dist-in 7.384 None PTR1007 PTR1007 XRAY 2.06 0.194 0.222 A 308 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnf TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VNFB 841 1131 1132.0 R6S:61201 Type1 Inactive DFGin 6.135 13.537 ABAminus -117.95, -1.25 -153.05, 143.83 -133.46, 28.47 293.84, 87.12 -62.91, -26.87 in-in in 8.658 Saltbr-in 2.815 HRD-in -75.84, -43.4 73.32, -33.47 in-in-out SNCiio in-out ActLoopNT-in 2.782 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -86.85, 129.3 APE9-dihe-in -107.76, 138.95 APE8-dihe-in -69.74, 71.65 APE8-rot-na 30.42 APE67-dihe-in -79.11, -3.05 -64.43, -23.08 APE12-dist-na 13.104 APE11-dist-na 12.478 APE10-dist-na 13.657 APE9-dist-out 8.756 None PTR1007 PTR1007 XRAY 2.06 0.194 0.222 B 308 291 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnf TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VNGA 841 1132 1132.0 R6M:1201 Type1 Inactive DFGin 6.284 13.57 ABAminus -121.14, 0.07 -154.35, 134.43 -129.13, 26.03 303.3, 79.75 -62.14, -18.06 in-in in 8.525 Saltbr-in 2.724 HRD-in -71.67, -45.35 75.28, -26.53 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -150.97, 166.68 APE9-dihe-in -128.34, 153.91 APE8-dihe-in -88.8, 83.93 APE8-rot-na 25.03 APE67-dihe-in -83.51, 0.54 -62.02, -27.23 APE12-dist-na 13.157 APE11-dist-na 10.042 APE10-dist-na 11.299 APE9-dist-in 7.281 None PTR1007 PTR1007 XRAY 2.5 0.213 0.251 A 308 292 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vng TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VNGB 843 1131 1132.0 R6M:1201 Type1 Inactive DFGin 6.084 13.441 ABAminus -119.47, 1.55 -153.39, 138.22 -129.51, 27.29 300.51, 84.65 -62.17, -19.61 in-in in 8.541 Saltbr-in 2.525 HRD-in -72.31, -45.0 74.08, -28.57 in-in-out SNCiio in-out ActLoopNT-in 2.912 ActLoopCT-out TYR APEdihe_ioiai APEdist_aaai APE10-dihe-in -151.17, 167.67 APE9-dihe-out -117.53, -162.05 APE8-dihe-in -85.16, 86.67 APE8-rot-na 28.85 APE67-dihe-in -81.37, 0.25 -61.69, -27.42 APE12-dist-na 13.199 APE11-dist-na 12.813 APE10-dist-na 13.033 APE9-dist-in 7.766 None PTR1007 PTR1007 XRAY 2.5 0.213 0.251 B 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vng TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VNHA 840 1132 1132.0 XZS:61201 Type1 Inactive DFGin 6.184 13.553 ABAminus -123.6, 24.97 -161.82, 132.95 -130.5, 37.69 300.8, 91.36 -67.84, -25.06 in-in in 8.429 Saltbr-in 2.79 HRD-in -79.9, -37.99 68.88, -41.62 in-in-in SNCiii in-in ActLoopNT-in 2.842 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.96, 147.55 APE9-dihe-in -142.31, 115.2 APE8-dihe-in -71.26, 87.66 APE8-rot-na 26.81 APE67-dihe-in -79.29, -8.01 -67.64, -27.75 APE12-dist-na 13.161 APE11-dist-na 9.563 APE10-dist-na 9.24 APE9-dist-in 7.563 None PTR1007 PTR1007 XRAY 2.4 0.231 0.267 A 308 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnh TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VNHB 843 1131 1132.0 XZS:61201 Type1 Inactive DFGin 5.985 13.692 ABAminus -107.49, 3.1 -151.23, 145.03 -137.2, 27.68 297.12, 87.64 -65.09, -22.9 in-in in 8.702 Saltbr-in 2.567 HRD-in -73.62, -34.79 67.37, -46.78 in-in-out SNCiio in-out ActLoopNT-in 2.897 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -67.53, 130.24 APE9-dihe-in -117.53, 132.31 APE8-dihe-in -69.15, 74.29 APE8-rot-na 26.97 APE67-dihe-in -84.52, -2.56 -66.6, -16.86 APE12-dist-na 13.295 APE11-dist-na 12.384 APE10-dist-na 12.816 APE9-dist-out 8.873 None PTR1007 PTR1007 XRAY 2.4 0.231 0.267 B 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnh TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VNIA 842 1132 1132.0 R61:1201 Type1 Inactive DFGin 6.372 13.893 ABAminus -132.82, -5.88 -134.64, 102.29 -105.41, 22.74 292.04, 85.81 -67.02, -17.75 in-in in 8.424 Saltbr-in 3.115 HRD-in -73.15, -47.37 76.86, -9.59 in-in-in SNCiii in-in ActLoopNT-in 2.801 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.58, 161.49 APE9-dihe-in -125.11, 123.14 APE8-dihe-in -78.8, 73.35 APE8-rot-na 30.02 APE67-dihe-in -81.16, -2.43 -62.36, -24.99 APE12-dist-na 12.841 APE11-dist-na 9.238 APE10-dist-na 10.179 APE9-dist-in 7.245 None PTR1007 PTR1007 XRAY 2.1 0.215 0.257 A 308 291 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vni TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VNIB 843 1131 1132.0 R61:1201 Type1 Inactive DFGin 6.265 13.847 ABAminus -131.4, -8.41 -135.18, 107.42 -105.53, 24.3 291.29, 84.71 -65.51, -19.14 in-in in 8.554 Saltbr-in 2.409 HRD-in -72.62, -46.4 76.72, -7.82 in-in-out SNCiio in-out ActLoopNT-in 2.851 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -99.99, 151.02 APE9-dihe-in -125.21, 137.98 APE8-dihe-in -70.39, 70.81 APE8-rot-na 33.16 APE67-dihe-in -80.33, -2.36 -65.48, -23.28 APE12-dist-na 13.019 APE11-dist-na 11.819 APE10-dist-na 13.639 APE9-dist-out 8.158 None PTR1007 PTR1007 XRAY 2.1 0.215 0.257 B 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vni TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VNJA 840 1132 1132.0 R5S:61201 Type1 Inactive DFGin 6.357 13.714 ABAminus -118.92, -6.85 -149.35, 132.07 -126.54, 24.6 294.41, 81.95 -61.91, -21.92 in-in in 8.624 Saltbr-in 2.76 HRD-in -73.19, -45.71 72.13, -3.37 in-in-in SNCiii in-in ActLoopNT-in 2.739 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.52, 135.78 APE9-dihe-in -128.55, 123.44 APE8-dihe-in -79.62, 75.87 APE8-rot-na 30.22 APE67-dihe-in -81.34, -2.92 -63.1, -25.95 APE12-dist-na 13.398 APE11-dist-na 9.488 APE10-dist-na 9.225 APE9-dist-in 7.102 None PTR1007 PTR1007 XRAY 1.9 0.185 0.211 A 308 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnj TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VNJB 842 1131 1132.0 R5S:61201 Type1 Inactive DFGin 6.205 13.567 ABAminus -116.85, -5.7 -149.84, 134.43 -128.79, 24.08 295.94, 84.61 -61.54, -23.54 in-in in 8.592 Saltbr-in 2.527 HRD-in -73.0, -46.01 70.61, -2.12 in-in-in SNCiii in-in ActLoopNT-in 2.733 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.48, 144.02 APE9-dihe-in -116.33, 142.06 APE8-dihe-in -73.73, 71.42 APE8-rot-na 32.45 APE67-dihe-in -82.06, -3.3 -62.97, -22.66 APE12-dist-na 13.304 APE11-dist-na 12.557 APE10-dist-na 13.498 APE9-dist-in 7.849 None PTR1007 PTR1007 XRAY 1.9 0.185 0.211 B 308 290 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnj TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VNKA 840 1132 1132.0 RXT:61201 Type1 Inactive DFGin 6.346 13.504 ABAminus -115.53, -9.34 -146.7, 139.79 -130.65, 29.08 297.41, 82.92 -64.51, -25.93 in-in in 8.37 Saltbr-in 2.823 HRD-in -72.4, -46.44 73.38, -6.51 in-in-in SNCiii in-in ActLoopNT-in 2.748 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.17, 138.86 APE9-dihe-in -125.9, 117.8 APE8-dihe-in -77.19, 70.99 APE8-rot-na 34.11 APE67-dihe-in -82.04, -0.49 -60.88, -24.48 APE12-dist-na 13.289 APE11-dist-na 9.078 APE10-dist-na 8.5 APE9-dist-in 6.887 None PTR1007 PTR1007 XRAY 2.0 0.219 0.244 A 308 292 1 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnk TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VNKB 840 1132 1132.0 RXT:61201 Type1 Inactive DFGin 6.484 13.471 ABAminus -114.35, -10.36 -144.27, 138.95 -130.65, 27.3 296.72, 80.78 -63.16, -24.64 in-in in 8.645 Saltbr-in 2.956 HRD-in -76.05, -48.13 73.42, -7.36 in-in-in SNCiii in-in ActLoopNT-in 2.805 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.22, 137.32 APE9-dihe-in -130.36, 114.06 APE8-dihe-in -78.87, 73.36 APE8-rot-na 31.4 APE67-dihe-in -82.55, -2.95 -58.49, -25.22 APE12-dist-na 13.259 APE11-dist-na 9.498 APE10-dist-na 8.289 APE9-dist-in 6.947 None PTR1007 PTR1007 XRAY 2.0 0.219 0.244 B 308 292 1 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnk TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VNKC 843 1131 1132.0 RXT:61201 Type1 Inactive DFGin 6.298 13.465 ABAminus -116.4, -8.39 -145.93, 138.87 -131.99, 24.75 293.4, 87.91 -62.13, -24.17 in-in in 8.433 Saltbr-in 2.775 HRD-in -70.05, -46.67 72.0, -3.71 in-in-out SNCiio in-out ActLoopNT-in 2.675 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -53.68, 136.82 APE9-dihe-in -128.24, 127.1 APE8-dihe-in -70.94, 70.21 APE8-rot-na 30.43 APE67-dihe-in -80.64, -2.41 -62.95, -22.96 APE12-dist-na 13.512 APE11-dist-na 12.93 APE10-dist-na 12.063 APE9-dist-out 8.085 None PTR1007 PTR1007 XRAY 2.0 0.219 0.244 C 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnk TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VNKD 843 1131 1132.0 RXT:61201 Type1 Inactive DFGin 6.112 13.457 ABAminus -114.41, -10.28 -145.24, 140.17 -129.26, 27.8 295.47, 88.05 -63.2, -27.61 in-in in 8.501 Saltbr-in 2.688 HRD-in -73.35, -47.11 71.95, -9.02 in-in-in SNCiii in-in ActLoopNT-in 2.72 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.65, 135.59 APE9-dihe-in -122.99, 135.75 APE8-dihe-in -71.71, 68.28 APE8-rot-na 32.34 APE67-dihe-in -81.87, -2.23 -61.51, -23.34 APE12-dist-na 13.283 APE11-dist-na 12.874 APE10-dist-na 12.716 APE9-dist-in 7.747 None PTR1007 PTR1007 XRAY 2.0 0.219 0.244 D 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnk TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VNLA 840 1132 1132.0 5W2:61201 Type1 Inactive DFGin 6.327 13.77 ABAminus -119.32, -0.49 -140.7, 133.57 -134.25, 25.52 297.74, 87.39 -65.79, -22.82 in-in in 8.396 Saltbr-in 2.695 HRD-in -67.09, -49.12 77.88, -9.34 in-in-in SNCiii in-in ActLoopNT-in 2.772 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.51, 153.05 APE9-dihe-in -134.74, 140.01 APE8-dihe-in -75.65, 76.24 APE8-rot-na 30.79 APE67-dihe-in -80.53, -2.68 -63.26, -24.89 APE12-dist-na 9.545 APE11-dist-na 10.935 APE10-dist-na 12.071 APE9-dist-in 7.676 None PTR1007 PTR1007 XRAY 2.4 0.218 0.257 A 308 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnl TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VNLB 840 1132 1132.0 5W2:61201 Type1 Inactive DFGin 6.267 13.703 ABAminus -120.39, -1.24 -140.56, 133.69 -134.27, 25.09 300.22, 88.0 -65.36, -23.57 in-in in 8.35 Saltbr-in 2.485 HRD-in -66.32, -49.37 78.14, -8.52 in-in-in SNCiii in-in ActLoopNT-in 2.862 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.03, 146.85 APE9-dihe-in -140.64, 128.61 APE8-dihe-in -81.75, 76.62 APE8-rot-na 30.24 APE67-dihe-in -80.98, -3.76 -62.39, -26.5 APE12-dist-na 8.506 APE11-dist-na 9.941 APE10-dist-na 8.971 APE9-dist-in 6.989 None PTR1007 PTR1007 XRAY 2.4 0.218 0.257 B 308 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnl TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VNLC 842 1131 1132.0 5W2:61201 Type1 Inactive DFGin 6.034 13.446 ABAminus -118.65, -2.25 -143.32, 137.65 -132.09, 28.15 298.49, 86.48 -64.1, -24.5 in-in in 8.587 Saltbr-in 2.629 HRD-in -67.65, -48.53 76.35, -9.72 in-in-out SNCiio in-out ActLoopNT-in 2.829 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -78.17, 150.96 APE9-dihe-in -134.19, 139.06 APE8-dihe-in -75.25, 71.72 APE8-rot-na 30.81 APE67-dihe-in -79.64, -2.96 -65.81, -24.18 APE12-dist-na 13.37 APE11-dist-na 12.542 APE10-dist-na 13.321 APE9-dist-out 8.458 None PTR1007 PTR1007 XRAY 2.4 0.218 0.257 C 308 290 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnl TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VNLD 843 1131 1132.0 5W2:61201 Type1 Inactive DFGin 6.125 13.445 ABAminus -118.2, -3.11 -143.32, 139.15 -131.54, 28.79 298.46, 86.52 -63.72, -23.5 in-in in 8.453 Saltbr-in 2.499 HRD-in -67.45, -48.99 77.0, -9.54 in-in-out SNCiio in-out ActLoopNT-in 2.925 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -71.97, 152.24 APE9-dihe-in -132.29, 144.67 APE8-dihe-in -70.93, 73.22 APE8-rot-na 30.09 APE67-dihe-in -80.02, -3.29 -64.41, -24.13 APE12-dist-na 13.607 APE11-dist-na 12.431 APE10-dist-na 13.393 APE9-dist-out 8.045 None PTR1007 PTR1007 XRAY 2.4 0.218 0.257 D 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnl TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VNMA 840 1132 1132.0 R5Y:61201 Type1 Inactive DFGin 6.276 13.856 ABAminus -161.76, 45.15 -147.28, 91.94 -100.3, 24.04 301.04, 88.04 -66.18, -22.04 in-in in 8.445 Saltbr-in 2.795 HRD-in -70.38, -47.67 75.09, -3.21 in-in-in SNCiii in-in ActLoopNT-in 2.846 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.31, 147.1 APE9-dihe-in -133.78, 127.05 APE8-dihe-in -79.36, 82.18 APE8-rot-na 30.27 APE67-dihe-in -79.86, -2.09 -63.93, -27.28 APE12-dist-na 13.16 APE11-dist-na 9.337 APE10-dist-na 9.9 APE9-dist-in 7.078 None PTR1007 PTR1007 XRAY 2.2 0.2 0.238 A 308 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnm TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VNMB 843 1131 1132.0 R5Y:61201 Type1 Inactive DFGin 6.181 13.729 ABAminus -117.34, 7.17 -155.1, 140.98 -137.24, 30.83 296.86, 88.07 -64.53, -27.32 in-in in 8.498 Saltbr-in 2.667 HRD-in -72.3, -46.39 69.83, 0.54 in-in-in SNCiii in-in ActLoopNT-in 2.84 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.62, 127.37 APE9-dihe-in -107.62, 146.18 APE8-dihe-in -72.44, 70.75 APE8-rot-na 28.98 APE67-dihe-in -82.72, -2.53 -66.0, -19.57 APE12-dist-na 13.114 APE11-dist-na 12.515 APE10-dist-na 13.195 APE9-dist-in 7.954 None PTR1007 PTR1007 XRAY 2.2 0.2 0.238 B 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnm TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VS3A 843 1131 1132.0 R6V:61201 Type1 Inactive DFGin 6.172 13.4 ABAminus -113.69, -9.73 -145.44, 139.92 -129.95, 28.79 298.53, 82.06 -63.1, -23.05 in-in in 8.628 Saltbr-in 2.665 HRD-in -70.46, -47.53 70.83, 1.7 in-in-in SNCiii in-in ActLoopNT-in 2.716 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.96, 143.74 APE9-dihe-in -124.34, 136.67 APE8-dihe-in -71.53, 71.61 APE8-rot-na 30.56 APE67-dihe-in -80.97, -2.5 -64.33, -23.02 APE12-dist-na 13.534 APE11-dist-na 12.192 APE10-dist-na 12.955 APE9-dist-in 7.731 None PTR1007 PTR1007 XRAY 2.0 0.186 0.218 A 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vs3 TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VS3B 840 1132 1132.0 R6V:61201 Type1 Inactive DFGin 6.448 13.651 ABAminus -115.02, -9.81 -144.91, 138.32 -130.18, 30.61 296.48, 83.03 -64.54, -21.19 in-in in 8.591 Saltbr-in 2.758 HRD-in -72.75, -48.7 73.41, 1.11 in-in-in SNCiii in-in ActLoopNT-in 2.792 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.71, 137.37 APE9-dihe-in -128.13, 115.26 APE8-dihe-in -80.11, 76.19 APE8-rot-na 29.15 APE67-dihe-in -81.55, -1.54 -62.24, -25.56 APE12-dist-na 13.482 APE11-dist-na 9.569 APE10-dist-na 8.843 APE9-dist-in 6.816 None PTR1007 PTR1007 XRAY 2.0 0.186 0.218 B 308 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vs3 TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VSNA 840 1132 1132.0 RG4:61201 Type1 Inactive DFGin 6.387 13.682 ABAminus -109.72, -15.97 -143.49, 135.23 -126.22, 34.01 297.74, 73.77 -69.3, -17.68 in-in in 8.481 Saltbr-in 2.897 HRD-in -79.84, -47.55 78.38, -6.15 in-in-in SNCiii in-in ActLoopNT-in 2.801 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.38, 157.36 APE9-dihe-in -150.13, 136.5 APE8-dihe-in -88.29, 86.0 APE8-rot-na 31.5 APE67-dihe-in -79.48, -1.84 -66.44, -27.63 APE12-dist-na 13.264 APE11-dist-na 9.454 APE10-dist-na 9.789 APE9-dist-in 7.435 None PTR1007 PTR1007 XRAY 2.5 0.192 0.252 A 308 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vsn TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VSNB 842 1132 1132.0 RG4:61201 Type1 Inactive DFGin 6.533 13.616 ABAminus -117.93, -12.97 -144.23, 143.5 -132.58, 27.03 294.85, 82.1 -60.37, -24.95 in-in in 8.466 Saltbr-in 2.762 HRD-in -69.1, -47.38 74.26, -2.29 in-in-in SNCiii in-in ActLoopNT-in 2.732 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -88.77, 141.32 APE9-dihe-in -136.93, 114.67 APE8-dihe-in -78.68, 76.58 APE8-rot-na 34.47 APE67-dihe-in -78.91, -4.45 -63.01, -29.1 APE12-dist-na 13.466 APE11-dist-na 9.67 APE10-dist-na 8.649 APE9-dist-in 6.927 None PTR1007 PTR1007 XRAY 2.5 0.192 0.252 B 308 291 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vsn TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VSNC 843 1131 1132.0 RG4:61201 Type1 Inactive DFGin 6.034 13.511 ABAminus -107.84, -22.28 -138.6, 146.61 -138.13, 17.5 291.81, 81.19 -54.12, -30.2 in-in in 8.404 Saltbr-in 2.811 HRD-in -72.34, -46.8 72.49, -7.83 in-in-in SNCiii in-in ActLoopNT-in 2.793 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.1, 144.23 APE9-dihe-in -124.87, 143.11 APE8-dihe-in -74.05, 69.35 APE8-rot-na 33.67 APE67-dihe-in -74.69, -6.91 -60.31, -31.34 APE12-dist-na 13.033 APE11-dist-na 12.562 APE10-dist-na 12.591 APE9-dist-in 7.777 None PTR1007 PTR1007 XRAY 2.5 0.192 0.252 C 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vsn TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6VSND 843 1131 1132.0 RG4:61201 Type1 Inactive DFGin 6.309 13.563 ABAminus -113.0, -18.77 -145.19, 142.86 -134.87, 26.72 297.57, 84.55 -62.91, -20.18 in-in in 8.393 Saltbr-in 2.584 HRD-in -70.27, -45.5 73.77, -2.2 in-in-in SNCiii in-in ActLoopNT-in 2.795 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.43, 138.88 APE9-dihe-in -113.67, 149.04 APE8-dihe-in -68.65, 67.63 APE8-rot-na 29.35 APE67-dihe-in -83.91, -0.02 -57.93, -26.65 APE12-dist-na 13.214 APE11-dist-na 12.023 APE10-dist-na 12.863 APE9-dist-in 7.846 None PTR1007 PTR1007 XRAY 2.5 0.192 0.252 D 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vsn TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6WTNA 843 1132 1132.0 RXT:61204 Type1 Inactive DFGin 6.303 13.472 ABAminus -111.65, -11.4 -144.34, 142.04 -130.65, 26.85 297.43, 84.86 -63.08, -21.36 in-in in 8.376 Saltbr-in 2.731 HRD-in -72.34, -45.85 71.67, 3.57 in-in-none SNCiin in-none ActLoopNT-in 2.822 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 99.29 APE9-dihe-in -135.56, 143.51 APE8-dihe-in -77.16, 75.07 APE8-rot-na 31.93 APE67-dihe-in -77.79, -2.65 -63.55, -26.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.496 APE9-dist-in 7.601 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.83 0.188 0.208 A 309 284 6 0 0 4 [[545, 807], [849, 1125]] 2.0 6wtn TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6WTOA 843 1132 1132.0 3JW:61203 Type1 Inactive DFGin 6.295 13.728 ABAminus -110.91, -10.94 -144.37, 142.6 -132.91, 28.16 294.42, 82.44 -64.81, -24.56 in-in in 8.777 Saltbr-in 2.859 HRD-in -75.59, -46.13 71.34, -0.4 in-in-none SNCiin in-none ActLoopNT-in 2.874 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 111.14 APE8-dihe-in -79.27, 79.05 APE8-rot-na 31.58 APE67-dihe-in -75.7, -0.19 -66.04, -26.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.373 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.74 0.198 0.218 A 309 277 13 0 0 4 [[545, 807], [849, 1125]] 2.0 6wto TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6WTPA 844 1132 1132.0 U8P:61201 Type1 Inactive DFGin 6.337 13.488 ABAminus -105.78, -9.61 -139.27, 143.87 -139.06, 28.68 303.29, 89.31 -68.12, -18.66 in-in in 8.834 Saltbr-in 2.731 HRD-in -70.88, -49.52 74.24, 2.12 in-in-none SNCiin in-none ActLoopNT-in 2.912 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 144.61 APE8-dihe-in -75.02, 77.35 APE8-rot-na 29.42 APE67-dihe-in -78.13, 0.58 -67.05, -26.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.762 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.5 0.24 0.288 A 309 275 12 0 0 6 [[545, 807], [849, 1125]] 2.0 6wtp TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6WTQA 849 1132 1132.0 U8J:61201 Type1 Inactive DFGin 6.372 13.722 ABAminus -122.37, -1.18 -147.37, 138.84 -128.85, 28.14 290.84, 82.66 -70.09, -22.16 in-in in 8.292 Saltbr-in 2.737 HRD-in -76.48, -43.01 68.69, 3.02 in-in-out SNCiio in-out ActLoopNT-in 2.756 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 146.69 APE8-dihe-in -80.82, 73.73 APE8-rot-na 32.68 APE67-dihe-in -76.94, 0.52 -62.2, -25.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.081 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.8 0.193 0.213 A 309 263 21 0 0 4 [[545, 807], [849, 1125]] 2.0 6wtq TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
8G6ZA 843 1131 1132.0 YSI:1201 Type1 Inactive DFGin 6.507 13.481 ABAminus -112.8, -5.23 -143.49, 146.77 -138.83, 38.03 298.53, 91.36 -63.83, -28.22 in-in in 8.18 Saltbr-in 2.549 HRD-in -65.64, -52.64 73.67, 5.8 in-in-in SNCiii in-in ActLoopNT-in 2.945 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.74, 129.64 APE9-dihe-in -136.21, 150.63 APE8-dihe-in -82.42, 71.95 APE8-rot-na 35.87 APE67-dihe-in -78.82, 3.44 -55.51, -28.44 APE12-dist-na 9.983 APE11-dist-na 10.956 APE10-dist-na 12.332 APE9-dist-in 7.453 M1073S,F1076T PTR1007 PTR1007 XRAY 2.45 0.228 0.281 A 318 281 8 0 0 2 [[545, 807], [849, 1125]] 2.0 8g6z TYR_JAK2-2_HUMAN TYR 7.8e-87 296.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
8G6ZB 843 1131 1132.0 YSI:1201 Type1 Inactive DFGin 6.478 13.519 ABAminus -114.28, -24.13 -123.15, 146.92 -135.04, 38.65 297.12, 87.98 -64.32, -25.66 in-in in 8.328 Saltbr-in 2.534 HRD-in -64.88, -55.1 79.03, -3.13 in-in-in SNCiii in-in ActLoopNT-in 2.948 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.77, 129.6 APE9-dihe-in -136.97, 149.24 APE8-dihe-in -83.09, 73.37 APE8-rot-na 34.87 APE67-dihe-in -79.65, 4.6 -55.74, -28.56 APE12-dist-na 10.387 APE11-dist-na 10.793 APE10-dist-na 11.978 APE9-dist-in 7.415 M1073S,F1076T PTR1007 PTR1007 XRAY 2.45 0.228 0.281 B 318 280 9 0 0 2 [[545, 807], [849, 1125]] 2.0 8g6z TYR_JAK2-2_HUMAN TYR 7.8e-87 296.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
8G8OA 842 1130 1132.0 YT0:1201 Type1 Inactive DFGin 6.202 13.361 ABAminus -120.55, -4.2 -147.29, 140.78 -131.57, 35.21 298.42, 95.45 -70.36, -19.76 in-in in 8.192 Saltbr-in 2.533 HRD-in -67.5, -52.92 71.36, 0.27 in-in-in SNCiii in-in ActLoopNT-in 2.717 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -53.6, 147.72 APE9-dihe-in -134.85, 143.13 APE8-dihe-in -73.21, 78.3 APE8-rot-na 29.04 APE67-dihe-in -74.11, 1.81 -65.23, -33.21 APE12-dist-na 13.898 APE11-dist-na 10.893 APE10-dist-na 12.109 APE9-dist-in 7.437 M1073S,F1076T PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.2 0.189 0.231 A 318 282 7 0 0 0 [[545, 807], [849, 1125]] 2.0 8g8o TYR_JAK2-2_HUMAN TYR 7.8e-87 296.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
8G8OB 843 1130 1132.0 YT0:1201 Type1 Inactive DFGin 6.195 13.456 ABAminus -116.17, -2.6 -150.03, 138.73 -130.97, 33.74 298.07, 97.39 -67.58, -22.65 in-in in 8.303 Saltbr-in 2.5 HRD-in -66.68, -51.5 71.43, 0.69 in-in-none SNCiin in-none ActLoopNT-in 2.734 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 153.39 APE9-dihe-in -126.18, 143.79 APE8-dihe-in -69.22, 78.32 APE8-rot-na 30.12 APE67-dihe-in -74.43, 0.93 -67.38, -32.46 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.83 APE9-dist-in 7.655 M1073S,F1076T PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.2 0.189 0.231 B 318 279 9 0 0 3 [[545, 807], [849, 1125]] 2.0 8g8o TYR_JAK2-2_HUMAN TYR 7.8e-87 296.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
8G8XA 842 1130 1132.0 YT8:1201 Type1 Inactive DFGin 6.287 13.621 ABAminus -128.64, 13.57 -157.75, 139.94 -132.4, 23.74 294.22, 91.25 -59.33, -23.18 in-in in 8.275 Saltbr-in 2.663 HRD-in -73.44, -46.22 72.51, -9.33 in-in-in SNCiii in-in ActLoopNT-in 2.802 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -57.22, 138.12 APE9-dihe-in -120.1, 150.86 APE8-dihe-in -76.91, 73.06 APE8-rot-na 33.65 APE67-dihe-in -77.05, 1.87 -66.0, -28.97 APE12-dist-na 13.891 APE11-dist-na 11.252 APE10-dist-na 12.307 APE9-dist-in 7.589 M1073S,F1076T PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.97 0.197 0.236 A 318 279 10 0 0 0 [[545, 807], [849, 1125]] 2.0 8g8x TYR_JAK2-2_HUMAN TYR 7.8e-87 296.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
8G8XB 842 1130 1132.0 YT8:1201 Type1 Inactive DFGin 6.305 13.625 ABAminus -131.5, 13.18 -154.49, 140.48 -130.41, 26.19 295.07, 93.87 -67.86, -20.04 in-in in 8.318 Saltbr-in 2.66 HRD-in -75.4, -49.99 77.29, -20.66 in-in-none SNCiin in-none ActLoopNT-in 2.78 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 148.7 APE9-dihe-in -121.49, 150.25 APE8-dihe-in -78.15, 75.05 APE8-rot-na 34.71 APE67-dihe-in -78.89, 2.08 -66.22, -28.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.395 APE9-dist-in 7.624 M1073S,F1076T PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.97 0.197 0.236 B 318 283 6 0 0 3 [[545, 807], [849, 1125]] 2.0 8g8x TYR_JAK2-2_HUMAN TYR 7.8e-87 296.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
3IO7A 842 1130 1132.0 1P5:1 Type1 Inactive DFGin 6.301 13.815 ABAminus -112.16, -1.32 -145.89, 149.76 -140.76, 26.89 292.99, 90.84 -59.52, -22.75 in-in in 8.824 Saltbr-in 2.811 HRD-in -55.86, -45.98 63.25, 8.93 in-in-in SNCiii in-in ActLoopNT-in 2.869 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.54, 138.09 APE9-dihe-in -133.41, 110.4 APE8-dihe-in -73.98, 70.25 APE8-rot-na 29.13 APE67-dihe-in -67.35, -10.36 -61.07, -31.41 APE12-dist-na 10.917 APE11-dist-na 9.773 APE10-dist-na 9.373 APE9-dist-in 7.014 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.6 0.206 0.294 A 313 284 5 0 0 0 [[545, 807], [849, 1125]] 2.0 3io7 TYR_JAK2-2_HUMAN TYR 3.1e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
3IOKA 842 1130 1132.0 1P6:1201 Type1 Inactive DFGin 6.096 13.541 ABAminus -121.32, -1.67 -146.25, 142.19 -132.46, 26.61 298.26, 86.73 -60.37, -26.17 in-in in 8.866 Saltbr-in 2.758 HRD-in -69.45, -45.65 73.01, -14.13 in-in-in SNCiii in-in ActLoopNT-in 2.893 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -46.78, 118.71 APE9-dihe-in -139.1, 105.64 APE8-dihe-in -78.75, 70.53 APE8-rot-na 31.27 APE67-dihe-in -75.46, -3.39 -51.2, -30.09 APE12-dist-na 10.916 APE11-dist-na 9.84 APE10-dist-na 7.394 APE9-dist-in 7.058 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.1 0.228 0.27 A 313 287 2 0 0 0 [[545, 807], [849, 1125]] 2.0 3iok TYR_JAK2-2_HUMAN TYR 3.1e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
8BX9A 840 1132 1132.0 S59:61201 Type1 Inactive DFGin 6.282 13.313 ABAminus -115.66, -15.46 -143.67, 143.69 -132.35, 26.34 296.6, 90.45 -62.57, -27.31 in-in in 8.693 Saltbr-in 2.708 HRD-in -72.71, -45.4 77.34, -11.34 in-in-in SNCiii in-in ActLoopNT-in 2.812 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.37, 138.38 APE9-dihe-in -118.57, 132.52 APE8-dihe-in -81.71, 72.52 APE8-rot-na 30.52 APE67-dihe-in -77.4, -1.6 -57.61, -31.37 APE12-dist-na 10.348 APE11-dist-na 9.382 APE10-dist-na 10.331 APE9-dist-in 7.339 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.4 0.193 0.223 A 316 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8bx9 TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
8BX9B 840 1132 1132.0 S59:61201 Type1 Inactive DFGin 6.291 13.332 ABAminus -114.72, -14.51 -143.68, 140.34 -129.13, 28.22 298.96, 84.54 -63.48, -25.1 in-in in 8.666 Saltbr-in 2.644 HRD-in -70.33, -47.05 74.41, -10.04 in-in-in SNCiii in-in ActLoopNT-in 2.793 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.07, 136.0 APE9-dihe-in -119.91, 128.99 APE8-dihe-in -80.21, 75.11 APE8-rot-na 32.85 APE67-dihe-in -76.92, -1.3 -60.27, -31.85 APE12-dist-na 10.468 APE11-dist-na 9.724 APE10-dist-na 10.147 APE9-dist-in 7.285 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.4 0.193 0.223 B 316 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8bx9 TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
8BXCA 840 1132 1132.0 S4R:1201 Type1 Inactive DFGin 6.317 13.273 ABAminus -114.09, -8.87 -149.97, 142.12 -133.77, 26.82 296.68, 81.56 -66.21, -23.2 in-in in 8.414 Saltbr-in 2.829 HRD-in -70.66, -50.65 75.15, -2.01 in-in-in SNCiii in-in ActLoopNT-in 2.751 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -59.68, 118.56 APE9-dihe-in -120.33, 123.76 APE8-dihe-in -80.89, 77.22 APE8-rot-na 32.94 APE67-dihe-in -79.78, -1.06 -63.1, -26.51 APE12-dist-na 11.275 APE11-dist-na 10.016 APE10-dist-na 9.625 APE9-dist-in 7.187 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.9 0.185 0.212 A 316 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8bxc TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
8BXCB 840 1131 1132.0 S4R:1202 Type1 Inactive DFGin 6.329 13.413 ABAminus -113.04, -4.23 -153.84, 142.12 -133.27, 27.51 295.22, 80.62 -63.7, -24.73 in-in in 8.348 Saltbr-in 2.687 HRD-in -71.82, -48.34 71.63, 1.45 in-in-out SNCiio in-out ActLoopNT-in 2.784 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 57.98, 67.78 APE9-dihe-in -109.48, 127.54 APE8-dihe-in -76.72, 73.7 APE8-rot-na 31.9 APE67-dihe-in -80.49, -2.19 -63.42, -23.88 APE12-dist-na 10.645 APE11-dist-na 10.848 APE10-dist-na 9.617 APE9-dist-in 7.152 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.9 0.185 0.212 B 316 292 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8bxc TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
8BXHA 840 1132 1132.0 C87:61201 Type1 Inactive DFGin 6.183 13.48 ABAminus -116.43, -2.68 -151.15, 148.41 -139.57, 22.33 295.88, 95.21 -64.33, -22.57 in-in in 8.486 Saltbr-in 2.667 HRD-in -70.75, -47.1 73.22, -3.09 in-in-in SNCiii in-in ActLoopNT-in 2.814 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.87, 128.71 APE9-dihe-in -114.3, 130.49 APE8-dihe-in -78.73, 74.05 APE8-rot-na 31.88 APE67-dihe-in -78.01, -2.31 -59.56, -30.79 APE12-dist-na 10.824 APE11-dist-na 9.715 APE10-dist-na 10.372 APE9-dist-in 7.251 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.3 0.146 0.168 A 316 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8bxh TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
8BPVA 840 1132 1132.0 6T3:61201 Type1 Inactive DFGin 6.233 13.683 ABAminus -116.56, -36.11 -124.2, 138.28 -129.59, 22.59 292.57, 84.89 -62.94, -24.65 in-in in 8.519 Saltbr-in 2.663 HRD-in -72.07, -43.66 72.8, -7.66 in-in-in SNCiii in-in ActLoopNT-in 2.816 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.52, 127.49 APE9-dihe-in -110.12, 130.52 APE8-dihe-in -77.35, 72.52 APE8-rot-na 32.09 APE67-dihe-in -77.69, -0.43 -59.29, -31.15 APE12-dist-na 10.581 APE11-dist-na 9.423 APE10-dist-na 10.23 APE9-dist-in 7.335 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.7 0.173 0.198 A 317 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8bpv TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
8BPWA 840 1132 1132.0 2V9:61201 Type1 Inactive DFGin 6.215 13.646 ABAminus -115.19, -48.31 -103.06, 116.82 -112.02, 18.76 287.81, 84.2 -63.54, -25.29 in-in in 8.484 Saltbr-in 2.996 HRD-in -64.59, -48.42 72.07, 3.03 in-in-in SNCiii in-in ActLoopNT-in 2.78 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.29, 123.58 APE9-dihe-in -114.84, 131.32 APE8-dihe-in -78.29, 74.82 APE8-rot-na 31.98 APE67-dihe-in -81.09, 3.66 -62.61, -27.13 APE12-dist-na 11.055 APE11-dist-na 10.031 APE10-dist-na 10.285 APE9-dist-in 7.466 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.8 0.163 0.197 A 317 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8bpw TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
8BPWB 840 1132 1132.0 2V9:61201 Type1 Inactive DFGin 6.297 13.887 ABAminus -111.51, -47.7 -108.79, 109.16 -104.77, 22.85 290.19, 83.67 -62.05, -23.01 in-in in 8.735 Saltbr-in 3.025 HRD-in -67.26, -44.61 65.05, 5.26 in-in-in SNCiii in-in ActLoopNT-in 2.761 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.76, 134.33 APE9-dihe-in -123.62, 132.56 APE8-dihe-in -77.84, 75.4 APE8-rot-na 31.91 APE67-dihe-in -80.86, -1.2 -58.88, -29.17 APE12-dist-na 11.075 APE11-dist-na 9.621 APE10-dist-na 10.468 APE9-dist-in 7.297 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.8 0.163 0.197 B 317 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8bpw TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4ZIMA 842 1131 1132.0 4OK:61201 Type1 Inactive DFGin 6.256 13.524 ABAminus -102.09, -6.97 -147.71, 148.02 -137.31, 29.43 300.7, 95.51 -55.05, -34.04 in-in in 8.595 Saltbr-in 2.797 HRD-in -53.87, -50.26 65.52, 9.71 in-in-in SNCiii in-in ActLoopNT-in 2.732 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -90.04, 117.49 APE9-dihe-in -95.25, 146.52 APE8-dihe-in -75.87, 68.0 APE8-rot-na 26.85 APE67-dihe-in -81.7, -1.44 -56.38, -28.63 APE12-dist-na 13.079 APE11-dist-na 12.404 APE10-dist-na 12.923 APE9-dist-in 7.594 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.65 0.204 0.274 A 321 287 3 0 0 0 [[545, 807], [849, 1125]] 2.0 4zim TYR_JAK2-2_HUMAN TYR 3.4e-87 298.0 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4ZIMB 839 1132 1132.0 4OK:61201 Type1 Inactive DFGin 6.31 13.573 ABAminus -101.81, -6.62 -147.61, 146.1 -135.69, 28.39 301.03, 95.65 -55.21, -33.63 in-in in 8.573 Saltbr-in 2.811 HRD-in -54.97, -54.79 72.19, 10.05 in-in-in SNCiii in-in ActLoopNT-in 2.73 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.16, 96.7 APE9-dihe-in -86.92, 138.92 APE8-dihe-in -75.37, 68.14 APE8-rot-na 27.6 APE67-dihe-in -81.8, -0.82 -56.64, -28.71 APE12-dist-na 12.564 APE11-dist-na 10.097 APE10-dist-na 12.046 APE9-dist-in 7.577 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.65 0.204 0.274 B 321 294 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4zim TYR_JAK2-2_HUMAN TYR 3.4e-87 298.0 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
5CF4A 843 1131 1132.0 50Y:4000 Type1 Inactive DFGin 6.295 13.579 ABAminus -103.56, 3.37 -156.43, 145.58 -135.49, 36.18 298.36, 87.67 -61.24, -32.94 in-in in 8.471 Saltbr-in 2.725 HRD-in -60.77, -47.53 65.86, 5.68 in-in-in SNCiii in-in ActLoopNT-in 2.753 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.53, 110.94 APE9-dihe-in -84.82, 139.81 APE8-dihe-in -78.84, 67.91 APE8-rot-na 30.09 APE67-dihe-in -80.84, 0.88 -52.35, -28.91 APE12-dist-na 13.014 APE11-dist-na 12.171 APE10-dist-na 13.191 APE9-dist-in 7.812 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.38 0.252 0.253 A 321 285 4 0 0 0 [[545, 807], [849, 1125]] 2.0 5cf4 TYR_JAK2-2_HUMAN TYR 3.4e-87 298.0 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
5CF4B 839 1132 1132.0 50Y:4000 Type1 Inactive DFGin 6.357 13.609 ABAminus -103.87, 5.06 -157.73, 143.99 -135.02, 36.0 298.42, 86.53 -61.5, -31.7 in-in in 8.449 Saltbr-in 2.768 HRD-in -62.02, -51.24 72.04, 5.25 in-in-out SNCiio in-out ActLoopNT-in 2.756 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 49.02, 84.4 APE9-dihe-in -103.49, 134.66 APE8-dihe-in -78.95, 68.18 APE8-rot-na 29.68 APE67-dihe-in -80.17, 0.94 -52.54, -29.08 APE12-dist-na 12.873 APE11-dist-na 11.403 APE10-dist-na 11.854 APE9-dist-in 7.867 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.38 0.252 0.253 B 321 293 1 0 0 0 [[545, 807], [849, 1125]] 2.0 5cf4 TYR_JAK2-2_HUMAN TYR 3.4e-87 298.0 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
5CF5A 842 1132 1132.0 50W:64000 Type1 Inactive DFGin 6.318 13.581 ABAminus -106.13, 0.46 -155.61, 145.68 -133.99, 32.21 297.37, 84.13 -60.56, -30.29 in-in in 8.499 Saltbr-in 2.776 HRD-in -63.82, -46.49 65.44, 2.47 in-in-out SNCiio in-out ActLoopNT-in 2.754 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out 18.66, 109.36 APE9-dihe-in -98.47, 150.84 APE8-dihe-in -80.28, 69.58 APE8-rot-na 31.09 APE67-dihe-in -78.37, -4.04 -58.67, -29.57 APE12-dist-na 12.911 APE11-dist-na 12.769 APE10-dist-na 13.276 APE9-dist-out 8.022 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.45 0.187 0.199 A 321 288 3 0 0 0 [[545, 807], [849, 1125]] 2.0 5cf5 TYR_JAK2-2_HUMAN TYR 3.4e-87 298.0 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
5CF5B 839 1132 1132.0 50W:64000 Type1 Inactive DFGin 6.366 13.586 ABAminus -105.36, 0.35 -155.34, 144.46 -134.01, 32.12 297.68, 83.75 -61.64, -29.62 in-in in 8.455 Saltbr-in 2.813 HRD-in -64.6, -47.11 66.71, 2.52 in-in-in SNCiii in-in ActLoopNT-in 2.763 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.2, 111.77 APE9-dihe-in -119.03, 140.54 APE8-dihe-in -81.94, 67.92 APE8-rot-na 30.1 APE67-dihe-in -78.8, -4.12 -52.51, -28.89 APE12-dist-na 9.69 APE11-dist-na 10.862 APE10-dist-na 11.845 APE9-dist-in 7.875 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.45 0.187 0.199 B 321 294 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5cf5 TYR_JAK2-2_HUMAN TYR 3.4e-87 298.0 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
5CF6A 842 1131 1132.0 50O:64000 Type1 Inactive DFGin 6.294 13.492 ABAminus -104.13, 1.62 -156.18, 144.42 -132.41, 30.68 297.44, 85.19 -58.71, -30.05 in-in in 8.402 Saltbr-in 2.803 HRD-in -64.91, -47.46 68.86, -4.67 in-in-in SNCiii in-in ActLoopNT-in 2.777 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.12, 114.93 APE9-dihe-in -87.57, 141.3 APE8-dihe-in -74.44, 75.42 APE8-rot-na 29.19 APE67-dihe-in -80.74, -1.76 -62.41, -25.89 APE12-dist-na 12.787 APE11-dist-na 12.279 APE10-dist-na 13.222 APE9-dist-in 7.898 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.5 0.187 0.214 A 321 287 3 0 0 0 [[545, 807], [849, 1125]] 2.0 5cf6 TYR_JAK2-2_HUMAN TYR 3.4e-87 298.0 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
5CF6B 839 1132 1132.0 50O:64000 Type1 Inactive DFGin 6.328 13.502 ABAminus -102.75, 1.1 -157.33, 143.82 -132.8, 30.05 297.51, 85.67 -59.73, -28.47 in-in in 8.342 Saltbr-in 2.832 HRD-in -65.26, -47.89 69.87, -4.78 in-in-in SNCiii in-in ActLoopNT-in 2.779 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.07, 114.0 APE9-dihe-in -116.42, 144.16 APE8-dihe-in -79.24, 65.15 APE8-rot-na 28.53 APE67-dihe-in -81.85, -1.06 -52.72, -29.08 APE12-dist-na 12.249 APE11-dist-na 10.493 APE10-dist-na 11.521 APE9-dist-in 7.569 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.5 0.187 0.214 B 321 290 4 0 0 0 [[545, 807], [849, 1125]] 2.0 5cf6 TYR_JAK2-2_HUMAN TYR 3.4e-87 298.0 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4E6DA 840 1132 1132.0 0NU:1201 Type1 Inactive DFGin 6.096 13.312 ABAminus -122.24, 3.75 -153.98, 144.84 -134.34, 24.14 296.82, 81.89 -55.12, -26.57 in-in in 8.248 Saltbr-in 2.649 HRD-in -69.92, -47.82 71.55, -0.63 in-in-in SNCiii in-in ActLoopNT-in 2.685 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.79, 131.23 APE9-dihe-in -111.58, 150.84 APE8-dihe-in -76.94, 65.01 APE8-rot-na 34.92 APE67-dihe-in -79.16, -3.09 -56.44, -27.07 APE12-dist-na 12.506 APE11-dist-na 13.314 APE10-dist-na 12.774 APE9-dist-in 7.967 Q853R,Y931F,D939E PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.22 0.162 0.203 A 298 288 5 0 0 0 [[545, 807], [849, 1125]] 2.0 4e6d TYR_JAK2-2_HUMAN TYR 4.9e-87 297.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4E6DB 840 1132 1132.0 0NU:1201 Type1 Inactive DFGin 6.306 13.387 ABAminus -117.06, 8.14 -158.35, 146.27 -137.86, 24.42 294.7, 80.09 -57.56, -27.02 in-in in 8.175 Saltbr-in 2.721 HRD-in -78.46, -40.84 73.08, -9.79 in-in-in SNCiii in-in ActLoopNT-in 2.796 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -62.69, 149.18 APE9-dihe-in -123.01, 137.44 APE8-dihe-in -75.9, 62.49 APE8-rot-na 355.6 APE67-dihe-in -81.97, -0.11 -52.79, -31.49 APE12-dist-na 7.25 APE11-dist-na 9.882 APE10-dist-na 11.579 APE9-dist-in 7.652 Q853R,Y931F,D939E PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.22 0.162 0.203 B 298 288 5 0 0 0 [[545, 807], [849, 1125]] 2.0 4e6d TYR_JAK2-2_HUMAN TYR 4.9e-87 297.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4E6QA 835 1132 1132.0 0NV:1201 Type1 Inactive DFGin 6.269 13.45 ABAminus -126.67, 13.67 -142.89, 143.88 -137.27, 22.15 296.58, 95.03 -64.63, -19.34 in-in in 8.366 Saltbr-in 2.874 HRD-in -63.97, -49.26 71.25, 9.0 in-in-out SNCiio in-out ActLoopNT-in 2.733 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -67.76, 142.09 APE9-dihe-in -117.85, 160.32 APE8-dihe-in -76.9, 79.46 APE8-rot-na 30.98 APE67-dihe-in -84.05, -2.56 -64.72, -24.34 APE12-dist-na 13.753 APE11-dist-na 13.35 APE10-dist-na 14.079 APE9-dist-out 8.198 Q853R,Y931F,D939E PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.948 0.189 0.234 A 298 298 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4e6q TYR_JAK2-2_HUMAN TYR 4.9e-87 297.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4E6QB 835 1132 1132.0 0NV:1201 Type1 Inactive DFGin 6.309 13.393 ABAminus -126.92, 5.36 -155.12, 144.98 -131.94, 23.19 295.89, 95.38 -67.11, -25.79 in-in in 8.118 Saltbr-in 2.373 HRD-in -66.33, -47.39 73.85, -0.29 in-in-out SNCiio in-out ActLoopNT-in 2.983 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -76.02, 138.29 APE9-dihe-in -102.23, 152.61 APE8-dihe-in -79.57, 76.43 APE8-rot-na 29.69 APE67-dihe-in -80.89, 2.35 -56.64, -31.57 APE12-dist-na 13.86 APE11-dist-na 12.97 APE10-dist-na 13.982 APE9-dist-out 8.456 Q853R,Y931F,D939E PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.948 0.189 0.234 B 298 298 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4e6q TYR_JAK2-2_HUMAN TYR 4.9e-87 297.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
2XA4A 843 1130 1132.0 AZ5:2131 Type1 Inactive DFGin 6.321 13.847 ABAminus -121.7, -5.46 -148.03, 137.82 -132.4, 31.72 296.05, 86.79 -68.8, -26.4 in-in in 8.543 Saltbr-in 2.486 HRD-in -71.2, -45.88 73.36, -2.24 in-in-none SNCiin in-none ActLoopNT-in 2.754 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 126.78 APE9-dihe-in -107.35, 156.84 APE8-dihe-in -77.77, 72.68 APE8-rot-na 32.4 APE67-dihe-in -78.43, -2.14 -60.39, -28.3 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.548 APE9-dist-in 7.401 K943A,K945A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.04 0.2 0.245 A 298 278 10 0 0 4 [[545, 807], [849, 1125]] 2.0 2xa4 TYR_JAK2-2_HUMAN TYR 1.1e-86 296.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
2XA4B 843 1131 1132.0 AZ5:2132 Type1 Inactive DFGin 6.36 13.939 ABAminus -114.45, -6.24 -145.12, 137.4 -128.21, 30.09 293.01, 86.49 -67.85, -24.85 in-in in 8.604 Saltbr-in 2.567 HRD-in -74.84, -43.44 74.17, -13.1 in-in-in SNCiii in-in ActLoopNT-in 2.846 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.26, 151.87 APE9-dihe-in -119.66, 134.15 APE8-dihe-in -79.04, 70.15 APE8-rot-na 35.49 APE67-dihe-in -81.02, -6.09 -54.48, -27.27 APE12-dist-na 999.0 APE11-dist-na 10.196 APE10-dist-na 11.428 APE9-dist-in 7.642 K943A,K945A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.04 0.2 0.245 B 298 277 12 0 0 1 [[545, 807], [849, 1125]] 2.0 2xa4 TYR_JAK2-2_HUMAN TYR 1.1e-86 296.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
3ZMMA 844 1130 1132.0 F9J:2133 Type1 Inactive DFGin 6.565 13.901 ABAminus -124.92, 4.32 -148.66, 145.32 -139.04, 35.94 291.38, 91.22 -76.64, -20.0 in-in in 8.47 Saltbr-in 2.626 HRD-in -74.41, -53.48 82.29, -12.58 in-in-none SNCiin in-none ActLoopNT-in 2.69 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 144.54 APE9-dihe-in -152.47, 158.96 APE8-dihe-in -87.79, 67.39 APE8-rot-na 35.81 APE67-dihe-in -75.46, -0.84 -60.96, -24.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.382 APE9-dist-in 7.793 K943A,K945A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.51 0.195 0.246 A 298 275 12 0 0 4 [[545, 807], [849, 1125]] 2.0 3zmm TYR_JAK2-2_HUMAN TYR 1.1e-86 296.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
3ZMMB 843 1131 1132.0 F9J:2134 Type1 Inactive DFGin 6.572 14.222 ABAminus -118.91, 2.8 -144.65, 134.95 -129.24, 31.19 288.83, 86.73 -65.15, -32.55 in-in in 8.494 Saltbr-in 2.631 HRD-in -67.1, -39.55 67.31, -4.77 in-in-in SNCiii in-in ActLoopNT-in 2.809 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -137.08, 109.88 APE9-dihe-in -113.35, 152.82 APE8-dihe-in -78.67, 75.19 APE8-rot-na 30.04 APE67-dihe-in -84.91, -6.79 -57.53, -23.83 APE12-dist-na 11.336 APE11-dist-na 11.902 APE10-dist-na 12.137 APE9-dist-in 7.69 K943A,K945A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.51 0.195 0.246 B 298 276 13 0 0 0 [[545, 807], [849, 1125]] 2.0 3zmm TYR_JAK2-2_HUMAN TYR 1.1e-86 296.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4C61A 844 1130 1132.0 LMM:2133 Type1 Inactive DFGin 6.532 13.992 ABAminus -100.5, -7.49 -142.5, 135.85 -127.75, 28.69 291.26, 86.96 -61.78, -31.29 in-in in 8.46 Saltbr-in 2.748 HRD-in -61.21, -51.25 72.4, -7.24 in-in-none SNCiin in-none ActLoopNT-in 2.723 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 116.09 APE9-dihe-in -128.96, 149.61 APE8-dihe-in -80.23, 71.12 APE8-rot-na 29.74 APE67-dihe-in -78.54, -3.02 -52.78, -33.19 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.707 APE9-dist-in 7.497 K943A,K945A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.45 0.182 0.217 A 298 274 13 0 0 4 [[545, 807], [849, 1125]] 2.0 4c61 TYR_JAK2-2_HUMAN TYR 1.1e-86 296.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4C61B 843 1131 1132.0 LMM:3134 Type1 Inactive DFGin 6.587 13.964 ABAminus -99.29, -7.41 -144.35, 135.64 -128.8, 28.74 291.58, 87.68 -61.03, -31.63 in-in in 8.425 Saltbr-in 2.733 HRD-in -61.64, -51.8 71.18, -7.39 in-in-in SNCiii in-in ActLoopNT-in 2.717 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.27, 116.76 APE9-dihe-in -129.15, 144.96 APE8-dihe-in -79.41, 70.56 APE8-rot-na 30.9 APE67-dihe-in -79.29, -3.33 -51.49, -32.42 APE12-dist-na 10.495 APE11-dist-na 11.91 APE10-dist-na 11.206 APE9-dist-in 7.524 K943A,K945A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.45 0.182 0.217 B 298 276 13 0 0 0 [[545, 807], [849, 1125]] 2.0 4c61 TYR_JAK2-2_HUMAN TYR 1.1e-86 296.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4C62A 844 1130 1132.0 XWW:2133 Type1 Inactive DFGin 6.529 13.898 ABAminus -113.05, -0.79 -150.5, 138.69 -131.28, 30.16 295.66, 95.47 -70.5, -17.57 in-in in 8.529 Saltbr-in 2.745 HRD-in -77.66, -50.29 78.32, -7.51 in-in-none SNCiin in-none ActLoopNT-in 2.76 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 124.25 APE9-dihe-in -114.5, 154.43 APE8-dihe-in -78.75, 69.66 APE8-rot-na 32.02 APE67-dihe-in -77.58, -7.44 -57.08, -29.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.316 APE9-dist-in 7.438 K943A,K945A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.75 0.199 0.246 A 298 275 12 0 0 4 [[545, 807], [849, 1125]] 2.0 4c62 TYR_JAK2-2_HUMAN TYR 1.1e-86 296.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4C62B 843 1131 1132.0 XWW:2135 Type1 Inactive DFGin 6.485 13.894 ABAminus -114.61, 4.06 -154.86, 137.03 -130.79, 31.93 295.01, 94.29 -69.55, -19.77 in-in in 8.553 Saltbr-in 2.823 HRD-in -79.26, -45.4 75.54, -12.71 in-in-in SNCiii in-in ActLoopNT-in 2.771 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -104.27, 116.68 APE9-dihe-in -110.1, 148.45 APE8-dihe-in -73.84, 72.01 APE8-rot-na 31.1 APE67-dihe-in -81.36, -4.7 -56.44, -28.7 APE12-dist-na 12.231 APE11-dist-na 11.26 APE10-dist-na 12.209 APE9-dist-in 7.492 K943A,K945A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.75 0.199 0.246 B 298 273 16 0 0 0 [[545, 807], [849, 1125]] 2.0 4c62 TYR_JAK2-2_HUMAN TYR 1.1e-86 296.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
5HEZC 842 1132 1132.0 1M3:1201,1M3:1202 Type1,Allosteric Inactive DFGin 6.167 13.569 ABAminus -103.82, 3.86 -148.69, 138.92 -132.75, 28.94 299.92, 92.74 -60.0, -27.11 in-in in 8.287 Saltbr-in 2.747 HRD-in -60.66, -47.83 77.19, -22.6 in-in-out SNCiio in-out ActLoopNT-in 2.817 ActLoopCT-out TYR APEdihe_oioao APEdist_aaao APE10-dihe-out -104.85, 22.51 APE9-dihe-in -86.59, 123.97 APE8-dihe-out -80.09, -0.5 APE8-rot-na 27.2 APE67-dihe-out -118.37, -51.6 -67.71, 128.02 APE12-dist-na 10.904 APE11-dist-na 13.374 APE10-dist-na 11.281 APE9-dist-out 8.854 P1057A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.66 0.218 0.238 C 302 291 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5hez TYR_JAK2-2_HUMAN TYR 3.7e-87 297.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
2W1IB 843 1132 1132.0 No_ligand No_ligand Inactive DFGin 5.997 13.845 BLAminus -129.87, -167.39 53.3, 77.87 -90.81, 22.6 298.76, 93.77 -65.07, -29.79 in-out in 8.428 Saltbr-out 3.849 HRD-in -57.34, -41.14 62.34, 9.12 out-in-in SNCoii in-in ActLoopNT-in 2.721 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -53.98, 136.0 APE9-dihe-in -141.41, 130.69 APE8-dihe-in -74.31, 69.47 APE8-rot-na 31.54 APE67-dihe-in -71.28, -6.63 -56.8, -34.08 APE12-dist-na 10.481 APE11-dist-na 9.48 APE10-dist-na 10.251 APE9-dist-in 6.786 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.6 0.209 0.295 B 326 286 4 0 0 0 [[545, 807], [849, 1125]] 2.0 2w1i TYR_JAK2-2_HUMAN TYR 3.6e-87 298.0 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6DRWA 840 1131 1132.0 SKE:61201 Type1 Inactive DFGin 6.272 14.004 BLAminus -135.62, -164.15 53.36, 70.98 -94.26, 33.85 297.13, 87.99 -70.79, -31.52 in-out in 8.273 Saltbr-out 3.745 HRD-in -68.89, -41.09 70.39, -6.99 out-in-none SNCoin in-none ActLoopNT-in 2.729 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 112.68 APE8-dihe-in -73.32, 76.55 APE8-rot-na 28.19 APE67-dihe-in -76.44, -0.11 -65.53, -30.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.486 None PTR1007 PTR1007 XRAY 2.303 0.216 0.255 A 316 287 5 0 0 3 [[545, 807], [849, 1125]] 2.0 6drw TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
6TPDA 842 1130 1132.0 QZ8:1201 Type1 Inactive DFGin 6.63 14.76 BLAminus -124.83, -158.73 59.79, 63.27 -93.49, 16.99 294.26, 88.24 -63.81, -25.57 in-in in 8.328 Saltbr-in 3.335 HRD-in -71.82, -47.85 72.16, -6.01 in-in-out SNCiio in-out ActLoopNT-in 2.803 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 70.21, 68.81 APE9-dihe-in -104.96, 158.71 APE8-dihe-in -79.2, 75.08 APE8-rot-na 33.87 APE67-dihe-in -77.56, -1.44 -58.33, -26.98 APE12-dist-na 10.403 APE11-dist-na 12.515 APE10-dist-na 12.776 APE9-dist-in 7.862 None None None XRAY 1.99 0.226 0.278 A 289 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6tpd TYR_JAK2-2_HUMAN TYR 1e-85 293.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
5TQ4A 841 1132 1132.0 7GY:4000 Type1.5_Back Inactive DFGin 6.986 15.576 BLAminus -126.97, -150.42 5.26, 93.28 -93.68, 31.39 284.52, 81.78 -74.22, -14.45 in-in in 8.964 Saltbr-in 3.156 HRD-in -67.84, -48.95 79.15, -11.54 in-in-out SNCiio in-out ActLoopNT-in 2.969 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -95.18, 108.56 APE9-dihe-in -105.14, 150.08 APE8-dihe-in -86.77, 77.3 APE8-rot-na 31.15 APE67-dihe-in -77.77, -0.55 -58.88, -32.93 APE12-dist-na 11.62 APE11-dist-na 9.761 APE10-dist-na 11.634 APE9-dist-out 8.166 M1073S,F1076T PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.3 0.249 0.279 A 298 292 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5tq4 TYR_JAK2-2_HUMAN TYR 6.1e-87 297.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
5TQ3A 843 1132 1132.0 7GZ:4000 Type1.5_Back Inactive DFGin 6.737 14.799 None 172.87, 131.46 -138.34, 98.39 -97.83, 27.37 287.51, 86.01 -80.9, -8.4 in-in in 8.584 Saltbr-in 2.836 HRD-in -60.87, -46.98 70.99, 1.64 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.52, 122.1 APE9-dihe-in -107.12, 143.94 APE8-dihe-in -76.54, 73.52 APE8-rot-na 28.78 APE67-dihe-in -71.43, -5.04 -57.67, -36.56 APE12-dist-na 9.152 APE11-dist-na 10.628 APE10-dist-na 11.386 APE9-dist-in 7.326 M1073S,F1076T,I1126V PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.69 0.219 0.271 A 304 284 6 0 0 2 [[545, 807], [849, 1125]] 2.0 5tq3 TYR_JAK2-2_HUMAN TYR 6.6e-87 297.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
5TQ3B 843 1132 1132.0 7GZ:4001 Type1.5_Back Inactive DFGin 6.737 14.798 None 175.33, 157.26 -141.41, 99.71 -97.33, 27.05 288.19, 85.47 -80.15, -9.61 in-in in 8.574 Saltbr-in 2.88 HRD-in -62.69, -46.43 69.37, 2.93 in-in-in SNCiii in-in ActLoopNT-in 2.955 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.61, 127.26 APE9-dihe-in -88.47, 146.55 APE8-dihe-in -72.07, 80.22 APE8-rot-na 34.9 APE67-dihe-in -69.96, -5.59 -60.36, -37.68 APE12-dist-na 12.144 APE11-dist-na 10.877 APE10-dist-na 11.876 APE9-dist-in 7.199 M1073S,F1076T,I1126V PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.69 0.219 0.271 B 304 287 3 0 0 0 [[545, 807], [849, 1125]] 2.0 5tq3 TYR_JAK2-2_HUMAN TYR 6.6e-87 297.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
7RN6A 839 1130 1132.0 046:61201 Type2 Inactive DFGout 14.849 10.032 BBAminus -142.9, -161.3 -155.9, 101.54 -56.95, -47.21 271.11, 99.06 62.67, 34.57 in-in in 8.4 Saltbr-in 2.853 HRD-in -71.23, -54.0 79.2, -32.78 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nioai APEdist_aaao APE10-dihe-none 999.0, 23.78 APE9-dihe-in -68.64, 133.62 APE8-dihe-out -69.28, -14.0 APE8-rot-na 30.51 APE67-dihe-in -77.29, 3.35 -60.18, -24.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.997 APE9-dist-out 11.023 None PTR1007 PTR1007 XRAY 1.5 0.19 0.214 A 298 270 22 0 0 16 [[545, 807], [849, 1125]] 2.0 7rn6 TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
3UGCA 843 1129 1132.0 046:1201 Type2 Inactive DFGout 15.041 10.383 BBAminus -140.53, -160.06 -162.81, 97.88 -51.65, -50.95 277.97, 90.44 63.84, 37.94 in-in in 8.398 Saltbr-in 2.778 HRD-in -68.11, -58.01 83.55, -37.27 in-out-out SNCioo out-out ActLoopNT-out 14.979 ActLoopCT-out TYR APEdihe_oioai APEdist_aaao APE10-dihe-out -100.96, -0.55 APE9-dihe-in -75.25, 134.38 APE8-dihe-out -78.02, -9.14 APE8-rot-na 29.56 APE67-dihe-in -74.84, -0.63 -60.59, -24.73 APE12-dist-na 19.039 APE11-dist-na 16.385 APE10-dist-na 12.022 APE9-dist-out 11.188 Y1007F,Y1008F None None XRAY 1.34 0.177 0.189 A 295 274 13 0 0 13 [[545, 807], [849, 1125]] 2.0 3ugc TYR_JAK2-2_HUMAN TYR 4.6e-86 294.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
7TEUA 843 1131 1132.0 I6C:1201 Type2 Inactive DFGout 14.305 10.598 BBAminus -138.23, -157.36 -163.3, 103.15 -64.67, -46.44 280.47, 106.62 49.38, 50.86 in-in in 8.283 Saltbr-in 2.86 HRD-in -76.64, -47.89 74.84, -32.91 in-out-out SNCioo out-out ActLoopNT-out 16.198 ActLoopCT-out TYR APEdihe_oioai APEdist_aaao APE10-dihe-out -95.98, 15.17 APE9-dihe-in -100.26, 136.67 APE8-dihe-out -72.55, -11.79 APE8-rot-na 28.68 APE67-dihe-in -77.6, -0.85 -63.7, -21.24 APE12-dist-na 19.564 APE11-dist-na 16.952 APE10-dist-na 12.55 APE9-dist-out 11.163 Y1007F,Y1008F None None XRAY 1.45 0.194 0.207 A 317 276 13 0 0 13 [[545, 807], [849, 1125]] 2.0 7teu TYR_JAK2-2_HUMAN TYR 6e-86 293.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
4D1SA 842 1130 1132.0 BJG:1141 Type1 None DFGin 6.153 14.03 BLAminus -124.84, -163.04 46.78, 76.68 -90.28, 22.64 295.97, 91.18 -59.77, -25.09 in-in in 8.462 Saltbr-in 2.749 HRD-in -72.78, -44.48 72.51, -0.35 in-in-none SNCiin in-none ActLoopNT-in 2.776 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.85 APE8-dihe-in -79.29, 70.09 APE8-rot-na 33.83 APE67-dihe-in -78.27, -2.32 -57.11, -28.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.736 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.66 0.205 0.231 A 298 282 7 0 0 5 [[545, 807], [849, 1125]] 2.0 4d1s TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
5USYA 840 1130 1132.0 SKE:1201 Type1 None DFGin 6.298 14.188 BLAminus -130.23, -164.34 47.33, 79.32 -93.1, 20.71 291.84, 98.58 -62.97, -21.55 in-in in 8.613 Saltbr-in 2.803 HRD-in -71.47, -46.11 68.35, -0.6 in-in-none SNCiin in-none ActLoopNT-in 2.735 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.57 APE8-dihe-in -78.81, 76.11 APE8-rot-na 30.98 APE67-dihe-in -83.0, 0.49 -61.55, -24.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.265 None PTR1007 PTR1007 XRAY 2.0 0.178 0.216 A 316 288 3 0 0 3 [[545, 807], [849, 1125]] 2.0 5usy TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
5USYB 840 1130 1132.0 SKE:1201 Type1 None DFGin 6.309 14.253 BLAminus -121.96, -156.65 31.13, 87.35 -93.3, 22.45 292.93, 84.2 -66.48, -18.97 in-in in 8.443 Saltbr-in 2.973 HRD-in -70.92, -45.61 67.52, 2.98 in-in-none SNCiin in-none ActLoopNT-in 2.725 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.82 APE8-dihe-in -82.14, 78.44 APE8-rot-na 33.08 APE67-dihe-in -81.92, -0.91 -60.29, -26.19 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.406 None PTR1007 PTR1007 XRAY 2.0 0.178 0.216 B 316 288 3 0 0 3 [[545, 807], [849, 1125]] 2.0 5usy TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2

TYR_JAK2-2 (Tyrosine-protein kinase JAK2)

Total number of chains: 180
Active chains: 37
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 128 71.1% 8BXHA
DFGin BLAminus 47 26.1% AF-O60674-K2A
DFGout BBAminus 3 1.7% 3UGCA
DFGin None 2 1.1% 5TQ3B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
JAK2_HUMAN AF-O60674-K2A O60674 841 1132 1132.0 No_ligand No_ligand Active DFGin 6.076 13.511 BLAminus -134.61, -173.69 52.08, 73.04 -83.89, 16.61 294.74, 89.28 -62.65, -26.85 in-in in 8.222 Saltbr-in 2.679 HRD-in -66.64, -44.29 64.49, -16.9 in-in-in SNCiii in-in ActLoopNT-in 2.873 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.63, 129.01 APE9-dihe-in -134.95, 135.87 APE8-dihe-in -76.24, 67.38 APE8-rot-na 35.11 APE67-dihe-in -76.66, -11.38 -54.24, -26.75 APE12-dist-na 10.548 APE11-dist-na 9.777 APE10-dist-na 10.368 APE9-dist-in 7.016 None None None AF2 -1.0 1.0 1.0 A 292 292 0 0 0 0 [[545, 807], [849, 1125]] 2.0 AF-O60674-K2 Homo sapiens TYR_JAK2-2_HUMAN TYR 2.4e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN AF-O60674-K4A O60674 841 1132 1132.0 No_ligand No_ligand Active DFGin 6.183 13.728 BLAminus -124.83, -169.75 47.53, 87.52 -95.54, 11.39 291.22, 87.41 -58.23, -35.02 in-in in 8.101 Saltbr-in 2.69 HRD-in -71.89, -46.5 63.37, -4.19 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -53.03, 124.77 APE9-dihe-in -142.44, 144.76 APE8-dihe-in -76.91, 66.4 APE8-rot-na 36.22 APE67-dihe-in -74.84, -12.36 -51.58, -31.85 APE12-dist-na 12.698 APE11-dist-na 9.962 APE10-dist-na 10.367 APE9-dist-in 6.61 None None None AF2 -1.0 1.0 1.0 A 292 292 0 0 0 0 [[545, 807], [849, 1125]] 2.0 AF-O60674-K4 Homo sapiens TYR_JAK2-2_HUMAN TYR 2.4e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4YTCA O60674 842 1130 1132.0 4HW:4000 Type1 Active DFGin 6.284 13.631 BLAminus -129.66, -176.22 51.29, 90.56 -102.75, 24.38 294.82, 85.35 -54.0, -39.57 in-in in 8.35 Saltbr-in 2.805 HRD-in -56.35, -51.38 71.22, -20.89 in-in-in SNCiii in-in ActLoopNT-in 2.788 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.0, 125.77 APE9-dihe-in -125.82, 130.76 APE8-dihe-in -79.99, 71.65 APE8-rot-na 31.05 APE67-dihe-in -75.16, -3.9 -53.22, -32.81 APE12-dist-na 10.704 APE11-dist-na 9.782 APE10-dist-na 9.936 APE9-dist-in 7.17 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.16 0.191 0.213 A 296 286 3 0 0 0 [[545, 807], [849, 1125]] 2.0 4ytc Homo sapiens TYR_JAK2-2_HUMAN TYR 2.5e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4YTFA O60674 842 1130 1132.0 4HZ:4000 Type1 Active DFGin 6.37 13.978 BLAminus -125.72, -175.3 45.63, 83.96 -89.3, 17.99 291.34, 92.01 -59.67, -25.51 in-in in 8.149 Saltbr-in 2.876 HRD-in -60.23, -48.26 68.84, -2.8 in-in-in SNCiii in-in ActLoopNT-in 2.841 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -61.86, 130.64 APE9-dihe-in -127.42, 133.95 APE8-dihe-in -81.26, 70.38 APE8-rot-na 32.03 APE67-dihe-in -72.41, -3.79 -52.3, -34.22 APE12-dist-na 10.964 APE11-dist-na 9.902 APE10-dist-na 10.371 APE9-dist-in 7.059 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.78 0.184 0.213 A 296 285 4 0 0 0 [[545, 807], [849, 1125]] 2.0 4ytf Homo sapiens TYR_JAK2-2_HUMAN TYR 2.5e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4YTHA O60674 842 1130 1132.0 467:4000 Type1 Active DFGin 6.501 14.25 BLAminus -123.79, 177.05 52.02, 90.63 -96.87, 16.55 287.94, 81.01 -60.81, -22.17 in-in in 8.35 Saltbr-in 2.868 HRD-in -56.47, -50.57 69.99, -4.7 in-in-in SNCiii in-in ActLoopNT-in 2.789 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.19, 125.25 APE9-dihe-in -116.48, 132.76 APE8-dihe-in -83.33, 72.42 APE8-rot-na 31.59 APE67-dihe-in -74.94, -3.66 -52.89, -33.66 APE12-dist-na 11.091 APE11-dist-na 9.973 APE10-dist-na 10.603 APE9-dist-in 7.355 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.04 0.185 0.215 A 296 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4yth Homo sapiens TYR_JAK2-2_HUMAN TYR 2.5e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4YTIA O60674 842 1130 1132.0 VJK:4000 Type1 Active DFGin 6.453 14.042 BLAminus -111.73, 173.97 45.15, 104.18 -106.31, 17.15 289.25, 83.82 -59.01, -26.24 in-in in 8.296 Saltbr-in 2.892 HRD-in -56.28, -51.06 69.78, -6.88 in-in-in SNCiii in-in ActLoopNT-in 2.787 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.56, 124.89 APE9-dihe-in -117.8, 129.73 APE8-dihe-in -82.47, 72.1 APE8-rot-na 31.97 APE67-dihe-in -75.31, -3.93 -52.08, -34.26 APE12-dist-na 10.981 APE11-dist-na 9.838 APE10-dist-na 10.188 APE9-dist-in 7.242 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.52 0.208 0.217 A 296 286 3 0 0 0 [[545, 807], [849, 1125]] 2.0 4yti Homo sapiens TYR_JAK2-2_HUMAN TYR 2.5e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4JIAA O60674 833 1132 1132.0 1K3:1201 Type1 Active DFGin 6.364 14.47 BLAminus -122.4, -163.0 65.63, 62.41 -96.29, 10.16 289.43, 100.3 -68.57, -11.9 in-in in 8.392 Saltbr-in 2.997 HRD-in -71.65, -49.59 74.75, -2.34 in-in-in SNCiii in-in ActLoopNT-in 2.792 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.81, 146.85 APE9-dihe-in -121.32, 149.01 APE8-dihe-in -77.17, 68.16 APE8-rot-na 29.8 APE67-dihe-in -77.58, -3.98 -58.25, -30.19 APE12-dist-na 13.472 APE11-dist-na 13.148 APE10-dist-na 13.123 APE9-dist-in 7.946 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.85 0.172 0.202 A 300 300 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4jia Homo sapiens TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4E4MA O60674 835 1132 1132.0 0NH:1201 Type1 Active DFGin 6.18 13.838 BLAminus -126.63, -156.25 24.74, 86.17 -92.72, 21.67 300.1, 90.36 -63.44, -19.58 in-in in 8.414 Saltbr-in 2.778 HRD-in -66.9, -48.08 75.55, -2.59 in-in-in SNCiii in-in ActLoopNT-in 2.676 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.21, 124.91 APE9-dihe-in -103.01, 150.72 APE8-dihe-in -78.71, 77.02 APE8-rot-na 32.56 APE67-dihe-in -75.65, -0.18 -64.92, -29.56 APE12-dist-na 13.669 APE11-dist-na 12.915 APE10-dist-na 12.815 APE9-dist-in 7.815 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.25 0.193 0.25 A 302 298 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4e4m Homo sapiens TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4E4MB O60674 835 1132 1132.0 0NH:1201 Type1 Active DFGin 6.372 14.203 BLAminus -118.84, -161.19 49.92, 72.51 -97.78, 25.28 298.31, 88.24 -69.84, -19.78 in-in in 8.441 Saltbr-in 2.744 HRD-in -61.1, -46.48 75.69, -8.22 in-in-in SNCiii in-in ActLoopNT-in 2.827 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.14, 74.01 APE9-dihe-in -58.89, 145.08 APE8-dihe-in -79.55, 72.25 APE8-rot-na 32.4 APE67-dihe-in -77.95, -3.75 -58.02, -29.09 APE12-dist-na 14.044 APE11-dist-na 12.156 APE10-dist-na 12.903 APE9-dist-in 7.921 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.25 0.193 0.25 B 302 298 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4e4m Homo sapiens TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4E4MD O60674 835 1132 1132.0 0NH:1201 Type1 Active DFGin 6.304 14.131 BLAminus -117.3, -162.8 35.37, 82.7 -96.62, 19.05 298.07, 93.7 -70.19, -12.95 in-in in 8.496 Saltbr-in 3.227 HRD-in -71.15, -48.12 79.59, -3.5 in-in-in SNCiii in-in ActLoopNT-in 2.793 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.18, 63.68 APE9-dihe-in -53.04, 143.19 APE8-dihe-in -78.69, 70.09 APE8-rot-na 32.31 APE67-dihe-in -79.35, -2.96 -56.35, -30.0 APE12-dist-na 14.288 APE11-dist-na 12.111 APE10-dist-na 12.723 APE9-dist-in 7.823 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.25 0.193 0.25 D 302 298 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4e4m Homo sapiens TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4E4ME O60674 835 1132 1132.0 0NH:1201 Type1 Active DFGin 6.15 13.969 BLAminus -129.52, -159.3 35.39, 81.53 -94.01, 23.95 298.27, 88.38 -61.49, -26.33 in-in in 8.438 Saltbr-in 2.72 HRD-in -66.9, -47.68 77.51, -1.6 in-in-in SNCiii in-in ActLoopNT-in 2.751 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.74, 130.71 APE9-dihe-in -111.94, 154.92 APE8-dihe-in -81.89, 77.11 APE8-rot-na 32.96 APE67-dihe-in -74.64, -3.77 -64.87, -30.41 APE12-dist-na 13.725 APE11-dist-na 13.029 APE10-dist-na 12.659 APE9-dist-in 7.874 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.25 0.193 0.25 E 302 298 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4e4m Homo sapiens TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4GMYA O60674 833 1132 1132.0 0X5:1201 Type1 Active DFGin 6.323 14.368 BLAminus -129.14, -151.03 59.75, 56.19 -91.99, 15.7 291.11, 106.6 -64.82, -18.52 in-in in 8.609 Saltbr-in 2.934 HRD-in -66.28, -44.86 75.83, -6.94 in-in-in SNCiii in-in ActLoopNT-in 2.748 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.06, 153.62 APE9-dihe-in -126.47, 151.79 APE8-dihe-in -73.92, 63.65 APE8-rot-na 25.85 APE67-dihe-in -78.85, -1.67 -58.34, -29.64 APE12-dist-na 13.157 APE11-dist-na 13.07 APE10-dist-na 13.214 APE9-dist-in 7.875 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.403 0.167 0.233 A 302 300 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4gmy Homo sapiens TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 8BX6A O60674 840 1132 1132.0 S5I:61201 Type1 Active DFGin 6.252 14.07 BLAminus -127.87, -163.53 51.31, 75.7 -93.06, 21.79 292.47, 95.0 -66.79, -21.79 in-in in 8.305 Saltbr-in 2.845 HRD-in -68.58, -46.29 73.08, -0.73 in-in-in SNCiii in-in ActLoopNT-in 2.803 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.3, 133.56 APE9-dihe-in -112.55, 137.83 APE8-dihe-in -81.04, 71.82 APE8-rot-na 35.5 APE67-dihe-in -78.45, 2.01 -54.32, -34.02 APE12-dist-na 10.6 APE11-dist-na 9.432 APE10-dist-na 10.852 APE9-dist-in 7.383 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.5 0.175 0.202 A 316 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8bx6 Homo sapiens TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 8BM2A O60674 840 1132 1132.0 QQC:61201 Type1 Active DFGin 6.495 13.668 BLAminus -136.57, -149.18 56.25, 58.85 -83.86, 18.34 294.62, 85.88 -65.29, -21.3 in-in in 8.604 Saltbr-in 2.709 HRD-in -74.1, -44.85 72.69, -1.57 in-in-in SNCiii in-in ActLoopNT-in 2.805 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.48, 126.84 APE9-dihe-in -115.75, 132.68 APE8-dihe-in -77.01, 74.29 APE8-rot-na 31.66 APE67-dihe-in -77.57, -2.52 -60.5, -31.86 APE12-dist-na 11.43 APE11-dist-na 10.253 APE10-dist-na 10.652 APE9-dist-in 7.29 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.5 0.178 0.202 A 317 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8bm2 Homo sapiens TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 8BM2B O60674 840 1132 1132.0 QQC:61201 Type1 Active DFGin 6.444 13.986 BLAminus -119.78, -156.07 50.59, 71.59 -91.98, 24.86 295.0, 85.76 -67.95, -20.12 in-in in 8.7 Saltbr-in 2.9 HRD-in -70.73, -45.45 70.42, 4.42 in-in-in SNCiii in-in ActLoopNT-in 2.821 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.07, 132.24 APE9-dihe-in -113.55, 136.93 APE8-dihe-in -79.1, 74.25 APE8-rot-na 36.64 APE67-dihe-in -79.53, -0.67 -57.94, -30.78 APE12-dist-na 10.834 APE11-dist-na 9.505 APE10-dist-na 11.03 APE9-dist-in 7.25 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.5 0.178 0.202 B 317 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8bm2 Homo sapiens TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 5WEVA O60674 833 1130 1132.0 9ZS:1201 Type1 Active DFGin 6.336 14.339 BLAminus -124.44, -159.19 59.63, 63.05 -90.04, 11.06 293.07, 100.36 -64.94, -15.33 in-in in 8.512 Saltbr-in 3.1 HRD-in -69.99, -46.25 71.47, -5.34 in-in-in SNCiii in-in ActLoopNT-in 2.811 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.7, 140.81 APE9-dihe-in -115.07, 150.19 APE8-dihe-in -75.39, 69.78 APE8-rot-na 28.35 APE67-dihe-in -78.28, -1.86 -59.75, -29.31 APE12-dist-na 13.533 APE11-dist-na 13.117 APE10-dist-na 13.038 APE9-dist-in 7.929 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.854 0.167 0.194 A 319 295 3 0 0 0 [[545, 807], [849, 1125]] 2.0 5wev Homo sapiens TYR_JAK2-2_HUMAN TYR 3.3e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 2W1IA O60674 843 1132 1132.0 L0I:2133 Type1 Active DFGin 6.093 14.09 BLAminus -142.48, -169.83 51.96, 80.95 -93.55, 29.52 297.23, 91.38 -67.11, -31.24 in-in in 8.397 Saltbr-in 3.063 HRD-in -62.15, -46.21 66.4, 9.56 in-in-in SNCiii in-in ActLoopNT-in 2.678 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -58.29, 137.22 APE9-dihe-in -138.71, 128.52 APE8-dihe-in -70.92, 67.85 APE8-rot-na 29.05 APE67-dihe-in -68.18, -7.39 -56.23, -38.03 APE12-dist-na 10.609 APE11-dist-na 9.405 APE10-dist-na 10.334 APE9-dist-in 6.885 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.6 0.209 0.295 A 326 286 4 0 0 0 [[545, 807], [849, 1125]] 2.0 2w1i Homo sapiens TYR_JAK2-2_HUMAN TYR 3.6e-87 298.0 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 5L3AA O60674 841 1130 1132.0 6DP:1201 Type1 Active DFGin 6.364 14.258 BLAminus -128.56, -160.96 38.41, 89.97 -102.03, 29.89 294.5, 81.8 -68.3, -33.79 in-in in 8.624 Saltbr-in 2.634 HRD-in -70.27, -44.2 70.55, -8.67 in-in-in SNCiii in-in ActLoopNT-in 2.668 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.08, 129.72 APE9-dihe-in -120.83, 133.92 APE8-dihe-in -79.34, 75.34 APE8-rot-na 33.39 APE67-dihe-in -79.15, -7.13 -61.09, -27.66 APE12-dist-na 9.341 APE11-dist-na 10.686 APE10-dist-na 11.323 APE9-dist-in 7.795 Y1007F,Y1008F None None XRAY 1.98 0.235 0.277 A 295 290 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5l3a Homo sapiens TYR_JAK2-2_HUMAN TYR 4.6e-86 294.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6AAJA O60674 843 1130 1132.0 9T6:1201 Type1 Active DFGin 6.538 14.489 BLAminus -115.63, -164.58 40.59, 91.02 -103.17, 27.63 288.93, 89.27 -64.3, -31.13 in-in in 8.29 Saltbr-in 3.264 HRD-in -73.79, -50.75 76.22, -8.05 in-in-in SNCiii in-in ActLoopNT-in 2.662 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -60.45, 121.7 APE9-dihe-in -116.64, 165.17 APE8-dihe-in -82.47, 75.26 APE8-rot-na 26.67 APE67-dihe-in -77.47, -9.05 -66.38, -30.21 APE12-dist-na 11.304 APE11-dist-na 10.897 APE10-dist-na 12.893 APE9-dist-in 7.857 K943A,K945A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.37 0.211 0.262 A 299 283 5 0 0 0 [[545, 807], [849, 1125]] 2.0 6aaj Homo sapiens TYR_JAK2-2_HUMAN TYR 1.1e-86 296.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6AAJB O60674 843 1131 1132.0 9T6:1201 Type1 Active DFGin 6.545 14.395 BLAminus -118.96, -159.53 45.76, 82.33 -100.65, 20.72 287.12, 93.43 -66.06, -21.73 in-in in 8.544 Saltbr-in 2.844 HRD-in -65.44, -45.07 71.55, -13.22 in-in-in SNCiii in-in ActLoopNT-in 2.882 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.56, 105.36 APE9-dihe-in -102.08, 153.39 APE8-dihe-in -76.19, 74.45 APE8-rot-na 31.79 APE67-dihe-in -76.6, 0.02 -66.92, -30.87 APE12-dist-na 999.0 APE11-dist-na 12.177 APE10-dist-na 12.802 APE9-dist-in 7.814 K943A,K945A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.37 0.211 0.262 B 299 274 15 0 0 2 [[545, 807], [849, 1125]] 2.0 6aaj Homo sapiens TYR_JAK2-2_HUMAN TYR 1.1e-86 296.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4BBEA O60674 841 1128 1132.0 3O4:2229 Type1 Active DFGin 6.402 14.33 BLAminus -125.98, -167.12 51.58, 81.25 -103.28, 27.34 292.11, 90.95 -69.35, -30.44 in-in in 8.615 Saltbr-in 2.753 HRD-in -62.89, -44.94 65.81, -4.46 in-in-in SNCiii in-in ActLoopNT-in 2.864 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.13, 115.7 APE9-dihe-in -138.06, 143.88 APE8-dihe-in -67.9, 80.65 APE8-rot-na 24.27 APE67-dihe-in -82.38, -6.87 -66.31, -22.61 APE12-dist-na 9.149 APE11-dist-na 12.713 APE10-dist-na 12.214 APE9-dist-in 7.687 D976N None None XRAY 1.9 0.344 0.359 A 298 288 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4bbe Homo sapiens TYR_JAK2-2_HUMAN TYR 9.7e-87 296.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4BBEB O60674 841 1128 1132.0 3O4:2229 Type1 Active DFGin 6.205 14.074 BLAminus -127.29, -170.77 54.58, 85.32 -105.55, 29.26 294.25, 89.97 -70.75, -26.52 in-in in 8.621 Saltbr-in 2.769 HRD-in -63.86, -45.65 65.48, -0.2 in-in-in SNCiii in-in ActLoopNT-in 2.964 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -125.21, 122.57 APE9-dihe-in -139.6, 145.84 APE8-dihe-in -69.38, 76.77 APE8-rot-na 24.94 APE67-dihe-in -79.94, -8.57 -65.61, -22.2 APE12-dist-na 10.177 APE11-dist-na 12.651 APE10-dist-na 11.956 APE9-dist-in 7.563 D976N None None XRAY 1.9 0.344 0.359 B 298 288 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4bbe Homo sapiens TYR_JAK2-2_HUMAN TYR 9.7e-87 296.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4BBEC O60674 841 1128 1132.0 3O4:2229 Type1 Active DFGin 6.293 14.188 BLAminus -126.43, -167.53 51.59, 82.16 -102.68, 26.48 292.93, 90.3 -68.82, -26.35 in-in in 8.712 Saltbr-in 2.609 HRD-in -65.59, -47.62 66.51, -1.03 in-in-in SNCiii in-in ActLoopNT-in 2.85 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -134.93, 105.75 APE9-dihe-in -133.87, 147.84 APE8-dihe-in -67.78, 81.68 APE8-rot-na 24.27 APE67-dihe-in -82.22, -3.34 -67.19, -22.64 APE12-dist-na 10.312 APE11-dist-na 12.852 APE10-dist-na 12.214 APE9-dist-in 7.68 D976N None None XRAY 1.9 0.344 0.359 C 298 288 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4bbe Homo sapiens TYR_JAK2-2_HUMAN TYR 9.7e-87 296.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4BBED O60674 841 1128 1132.0 3O4:2229 Type1 Active DFGin 6.399 14.306 BLAminus -126.45, -167.95 52.52, 81.86 -103.52, 26.55 291.97, 89.91 -69.01, -29.54 in-in in 8.606 Saltbr-in 2.731 HRD-in -63.92, -45.32 65.09, -4.3 in-in-in SNCiii in-in ActLoopNT-in 2.826 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.16, 106.33 APE9-dihe-in -128.2, 144.76 APE8-dihe-in -68.04, 81.17 APE8-rot-na 24.25 APE67-dihe-in -80.48, -9.22 -66.73, -22.27 APE12-dist-na 9.46 APE11-dist-na 12.666 APE10-dist-na 12.359 APE9-dist-in 7.793 D976N None None XRAY 1.9 0.344 0.359 D 298 288 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4bbe Homo sapiens TYR_JAK2-2_HUMAN TYR 9.7e-87 296.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4BBFA O60674 841 1128 1132.0 O19:2229 Type1 Active DFGin 6.31 13.682 BLAminus -122.28, 157.21 62.91, 103.68 -120.19, 22.73 295.23, 86.2 -48.8, -35.8 in-in in 8.418 Saltbr-in 2.631 HRD-in -73.08, -45.64 68.9, 4.29 in-in-in SNCiii in-in ActLoopNT-in 2.72 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.01, 125.11 APE9-dihe-in -136.65, 156.16 APE8-dihe-in -79.26, 68.68 APE8-rot-na 35.28 APE67-dihe-in -75.77, -5.49 -52.84, -31.24 APE12-dist-na 9.236 APE11-dist-na 12.578 APE10-dist-na 12.07 APE9-dist-in 7.484 D976N None None XRAY 2.0 0.232 0.289 A 298 288 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4bbf Homo sapiens TYR_JAK2-2_HUMAN TYR 9.7e-87 296.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4BBFB O60674 841 1128 1132.0 O19:2229 Type1 Active DFGin 6.579 14.152 BLAminus -105.04, -155.04 19.23, 107.45 -113.45, 24.27 291.25, 95.72 -57.33, -30.87 in-in in 8.405 Saltbr-in 2.719 HRD-in -66.38, -45.27 65.07, 1.26 in-in-in SNCiii in-in ActLoopNT-in 2.739 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -88.58, 126.22 APE9-dihe-in -128.56, 154.33 APE8-dihe-in -77.1, 75.24 APE8-rot-na 35.98 APE67-dihe-in -81.26, -2.64 -63.77, -23.03 APE12-dist-na 8.439 APE11-dist-na 12.975 APE10-dist-na 12.764 APE9-dist-in 7.646 D976N None None XRAY 2.0 0.232 0.289 B 298 288 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4bbf Homo sapiens TYR_JAK2-2_HUMAN TYR 9.7e-87 296.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4BBFC O60674 841 1128 1132.0 O19:2229 Type1 Active DFGin 6.539 14.131 BLAminus -104.07, -172.68 36.61, 102.28 -115.67, 23.77 291.54, 96.27 -45.14, -34.47 in-in in 8.461 Saltbr-in 2.759 HRD-in -62.09, -47.1 70.38, 6.53 in-in-in SNCiii in-in ActLoopNT-in 2.702 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -93.18, 129.11 APE9-dihe-in -138.58, 151.05 APE8-dihe-in -77.24, 74.09 APE8-rot-na 32.23 APE67-dihe-in -82.19, -2.12 -57.96, -26.71 APE12-dist-na 9.821 APE11-dist-na 13.104 APE10-dist-na 11.998 APE9-dist-in 7.665 D976N None None XRAY 2.0 0.232 0.289 C 298 288 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4bbf Homo sapiens TYR_JAK2-2_HUMAN TYR 9.7e-87 296.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4BBFD O60674 841 1128 1132.0 O19:2229 Type1 Active DFGin 6.286 13.514 BLAminus -118.87, 148.23 73.97, 103.66 -117.83, 24.63 298.53, 82.83 -57.3, -34.26 in-in in 8.351 Saltbr-in 2.67 HRD-in -74.8, -46.04 69.77, 0.83 in-in-in SNCiii in-in ActLoopNT-in 2.741 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.36, 121.84 APE9-dihe-in -135.14, 154.38 APE8-dihe-in -81.18, 76.48 APE8-rot-na 38.95 APE67-dihe-in -79.95, -2.38 -61.79, -29.08 APE12-dist-na 8.023 APE11-dist-na 12.521 APE10-dist-na 11.93 APE9-dist-in 7.383 D976N None None XRAY 2.0 0.232 0.289 D 298 288 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4bbf Homo sapiens TYR_JAK2-2_HUMAN TYR 9.7e-87 296.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 5TQ5A O60674 841 1131 1132.0 7GX:4000 Type1.5_Back Active DFGin 7.115 14.952 BLAminus -119.32, -142.58 8.61, 85.15 -90.27, 16.98 285.17, 79.58 -59.76, -25.38 in-in in 8.586 Saltbr-in 2.803 HRD-in -64.66, -52.67 75.62, -9.13 in-in-in SNCiii in-in ActLoopNT-in 2.735 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.04, 123.33 APE9-dihe-in -112.08, 150.1 APE8-dihe-in -79.42, 65.81 APE8-rot-na 31.26 APE67-dihe-in -78.66, 0.06 -53.84, -28.19 APE12-dist-na 10.284 APE11-dist-na 10.931 APE10-dist-na 12.071 APE9-dist-in 7.623 M1073S,F1076T None None XRAY 2.3 0.282 0.332 A 298 291 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5tq5 Homo sapiens TYR_JAK2-2_HUMAN TYR 6.1e-87 297.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 5TQ8A O60674 841 1131 1132.0 7GS:4000 Type1.5_Back Active DFGin 6.928 14.98 BLAminus -112.92, -147.32 8.13, 87.34 -90.44, 17.76 279.3, 79.39 -58.24, -25.27 in-in in 8.45 Saltbr-in 2.78 HRD-in -60.77, -51.81 74.15, 1.15 in-in-in SNCiii in-in ActLoopNT-in 2.784 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.68, 127.51 APE9-dihe-in -117.91, 153.17 APE8-dihe-in -80.73, 67.65 APE8-rot-na 28.53 APE67-dihe-in -77.2, -0.13 -49.08, -33.67 APE12-dist-na 9.59 APE11-dist-na 10.322 APE10-dist-na 11.653 APE9-dist-in 7.48 M1073S,F1076T None None XRAY 1.59 0.167 0.192 A 298 291 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5tq8 Homo sapiens TYR_JAK2-2_HUMAN TYR 6.1e-87 297.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 7Q7IA O60674 840 1131 1132.0 9I8:4000 Type1.5_Back Active DFGin 6.247 13.731 BLAminus -122.35, -168.71 42.75, 76.87 -84.65, 18.59 291.58, 89.35 -59.24, -27.3 in-in in 8.237 Saltbr-in 2.811 HRD-in -60.05, -48.79 69.76, -14.23 in-in-in SNCiii in-in ActLoopNT-in 2.823 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -62.82, 125.01 APE9-dihe-in -122.77, 133.38 APE8-dihe-in -82.92, 71.36 APE8-rot-na 34.06 APE67-dihe-in -75.58, -1.96 -52.18, -31.93 APE12-dist-na 10.376 APE11-dist-na 9.5 APE10-dist-na 9.908 APE9-dist-in 7.099 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.78 0.189 0.222 A 316 292 0 0 0 0 [[545, 807], [849, 1125]] 2.0 7q7i Homo sapiens TYR_JAK2-2_HUMAN TYR 7.6e-87 296.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 7Q7KA O60674 840 1131 1132.0 9I5:4000 Type1.5_Back Active DFGin 6.186 13.705 BLAminus -125.79, -166.32 44.92, 74.69 -86.44, 19.78 289.1, 91.09 -62.55, -24.66 in-in in 8.272 Saltbr-in 2.8 HRD-in -62.94, -47.62 72.62, -19.01 in-in-in SNCiii in-in ActLoopNT-in 2.803 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.24, 127.36 APE9-dihe-in -125.5, 133.64 APE8-dihe-in -82.56, 68.91 APE8-rot-na 32.36 APE67-dihe-in -75.19, -5.67 -51.59, -30.75 APE12-dist-na 10.234 APE11-dist-na 9.45 APE10-dist-na 10.03 APE9-dist-in 7.197 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.61 0.184 0.204 A 316 292 0 0 0 0 [[545, 807], [849, 1125]] 2.0 7q7k Homo sapiens TYR_JAK2-2_HUMAN TYR 7.6e-87 296.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 7Q7LA O60674 843 1131 1132.0 9I2:4000 Type1.5_Back Active DFGin 6.309 14.177 BLAminus -119.13, -162.07 32.41, 83.25 -90.84, 16.8 285.63, 88.13 -57.14, -30.61 in-in in 8.319 Saltbr-in 2.795 HRD-in -58.93, -46.4 69.45, -9.97 in-in-in SNCiii in-in ActLoopNT-in 2.796 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.23, 129.86 APE9-dihe-in -123.68, 128.22 APE8-dihe-in -81.04, 69.0 APE8-rot-na 30.72 APE67-dihe-in -77.79, -3.43 -50.71, -28.47 APE12-dist-na 10.666 APE11-dist-na 9.404 APE10-dist-na 9.975 APE9-dist-in 7.117 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.97 0.172 0.196 A 316 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 7q7l Homo sapiens TYR_JAK2-2_HUMAN TYR 7.6e-87 296.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 7Q7WA O60674 840 1131 1132.0 9HR:4000 Type1.5_Back Active DFGin 6.41 14.538 BLAminus -113.89, -148.73 11.33, 84.65 -87.0, 16.91 281.85, 82.61 -58.95, -25.64 in-in in 8.333 Saltbr-in 2.795 HRD-in -66.63, -42.74 68.35, -2.19 in-in-in SNCiii in-in ActLoopNT-in 2.789 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -65.94, 122.57 APE9-dihe-in -117.51, 131.31 APE8-dihe-in -82.75, 70.26 APE8-rot-na 32.08 APE67-dihe-in -75.91, -5.95 -51.18, -28.75 APE12-dist-na 10.493 APE11-dist-na 9.493 APE10-dist-na 10.105 APE9-dist-in 6.898 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.85 0.181 0.227 A 316 292 0 0 0 0 [[545, 807], [849, 1125]] 2.0 7q7w Homo sapiens TYR_JAK2-2_HUMAN TYR 7.6e-87 296.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 3JY9A O60674 842 1130 1132.0 JZH:1 Type1.5_Back Active DFGin 6.313 14.253 BLAminus -123.65, -154.99 17.68, 87.85 -86.97, 19.54 286.71, 84.2 -50.28, -36.18 in-in in 8.321 Saltbr-in 2.819 HRD-in -57.47, -44.36 69.83, -15.51 in-in-in SNCiii in-in ActLoopNT-in 2.835 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.55, 129.55 APE9-dihe-in -129.25, 135.47 APE8-dihe-in -83.14, 70.63 APE8-rot-na 34.02 APE67-dihe-in -70.23, -8.08 -50.19, -35.53 APE12-dist-na 10.87 APE11-dist-na 9.694 APE10-dist-na 9.976 APE9-dist-in 7.206 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.1 0.201 0.271 A 311 284 5 0 0 0 [[545, 807], [849, 1125]] 2.0 3jy9 Homo sapiens TYR_JAK2-2_HUMAN TYR 3e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 3KCKA O60674 842 1130 1132.0 3KC:1 Type1.5_Back Active DFGin 6.245 14.399 BLAminus -122.33, -150.45 29.06, 78.16 -95.54, 2.33 291.6, 90.27 -50.57, -18.29 in-in in 8.364 Saltbr-in 2.926 HRD-in -68.02, -44.9 71.68, -16.29 in-in-in SNCiii in-in ActLoopNT-in 2.715 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -65.17, 121.75 APE9-dihe-in -129.14, 127.5 APE8-dihe-in -83.31, 77.57 APE8-rot-na 25.02 APE67-dihe-in -76.11, -1.18 -59.14, -29.17 APE12-dist-na 11.365 APE11-dist-na 10.127 APE10-dist-na 9.498 APE9-dist-in 7.304 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.2 0.244 0.296 A 313 287 2 0 0 0 [[545, 807], [849, 1125]] 2.0 3kck Homo sapiens TYR_JAK2-2_HUMAN TYR 3.1e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 5HEZA O60674 842 1132 1132.0 1M3:1203,1M3:1204 Allosteric,Type1 Inactive DFGin 6.181 13.576 ABAminus -103.67, 3.96 -149.83, 138.2 -131.72, 28.65 300.8, 91.99 -61.15, -26.6 in-in in 8.296 Saltbr-in 2.743 HRD-in -60.6, -48.83 77.58, -20.92 in-in-out SNCiio in-out ActLoopNT-in 2.826 ActLoopCT-out TYR APEdihe_oioao APEdist_aaao APE10-dihe-out -93.22, 48.54 APE9-dihe-in -69.64, 140.78 APE8-dihe-out -72.52, 2.67 APE8-rot-na 25.71 APE67-dihe-out -117.46, -52.02 -67.01, 128.79 APE12-dist-na 14.579 APE11-dist-na 11.317 APE10-dist-na 12.268 APE9-dist-out 8.372 P1057A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.66 0.218 0.238 A 302 289 2 0 0 0 [[545, 807], [849, 1125]] 2.0 5hez Homo sapiens TYR_JAK2-2_HUMAN TYR 3.7e-87 297.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 5HEZB O60674 842 1132 1132.0 1M3:1202,1M3:1203 Allosteric,Type1 Inactive DFGin 6.191 13.527 ABAminus -103.41, 2.96 -148.35, 138.17 -130.74, 29.01 299.81, 93.06 -60.8, -25.75 in-in in 8.324 Saltbr-in 2.743 HRD-in -61.03, -48.59 78.08, -21.43 in-in-out SNCiio in-out ActLoopNT-in 2.824 ActLoopCT-out TYR APEdihe_oioao APEdist_aaao APE10-dihe-out 45.93, 11.51 APE9-dihe-in -79.34, 131.16 APE8-dihe-out -79.25, -1.75 APE8-rot-na 28.01 APE67-dihe-out -118.77, -49.59 -69.25, 127.98 APE12-dist-na 12.453 APE11-dist-na 13.412 APE10-dist-na 12.364 APE9-dist-out 8.94 P1057A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.66 0.218 0.238 B 302 291 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5hez Homo sapiens TYR_JAK2-2_HUMAN TYR 3.7e-87 297.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 5HEZD O60674 842 1132 1132.0 1M3:1202,1M3:1203 Allosteric,Type1 Inactive DFGin 6.189 13.538 ABAminus -102.35, 3.11 -149.37, 138.24 -132.2, 28.53 300.15, 93.07 -59.55, -26.76 in-in in 8.302 Saltbr-in 2.776 HRD-in -60.7, -48.85 78.34, -23.62 in-in-out SNCiio in-out ActLoopNT-in 2.817 ActLoopCT-out TYR APEdihe_oioao APEdist_aaao APE10-dihe-out -170.07, -9.93 APE9-dihe-in -55.73, 129.12 APE8-dihe-out -79.78, -1.34 APE8-rot-na 27.62 APE67-dihe-out -118.44, -49.74 -68.49, 127.41 APE12-dist-na 10.894 APE11-dist-na 13.836 APE10-dist-na 11.844 APE9-dist-out 8.922 P1057A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.66 0.218 0.238 D 302 291 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5hez Homo sapiens TYR_JAK2-2_HUMAN TYR 3.7e-87 297.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 7UYWA O60674 842 1131 1132.0 OV0:1201 Type1 Inactive DFGin 6.162 13.552 ABAminus -102.13, -65.77 -97.61, 118.73 -112.34, 34.06 302.3, 86.62 -68.86, -35.74 in-in in 8.446 Saltbr-in 3.127 HRD-in -63.99, -43.03 64.14, 10.59 in-in-in SNCiii in-in ActLoopNT-in 2.857 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.32, 131.93 APE9-dihe-in -128.43, 132.61 APE8-dihe-in -78.21, 78.3 APE8-rot-na 32.14 APE67-dihe-in -77.48, -5.27 -63.06, -29.41 APE12-dist-na 10.281 APE11-dist-na 9.748 APE10-dist-na 10.244 APE9-dist-in 6.83 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.51 0.21 0.26 A 291 290 0 0 0 0 [[545, 807], [849, 1125]] 2.0 7uyw Homo sapiens TYR_JAK2-2_HUMAN TYR 2.3e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6BBVA O60674 843 1131 1132.0 D7D:1201 Type1 Inactive DFGin 6.199 13.255 ABAminus -113.98, 5.62 -153.05, 141.18 -132.03, 30.21 297.46, 84.49 -58.98, -27.69 in-in in 8.296 Saltbr-in 2.796 HRD-in -69.62, -44.96 69.56, -11.16 in-in-in SNCiii in-in ActLoopNT-in 2.782 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -57.98, 116.85 APE9-dihe-in -106.89, 148.6 APE8-dihe-in -82.02, 70.74 APE8-rot-na 31.49 APE67-dihe-in -79.85, -2.28 -54.85, -30.11 APE12-dist-na 13.759 APE11-dist-na 12.417 APE10-dist-na 12.232 APE9-dist-in 7.818 None None None XRAY 1.8 0.178 0.215 A 298 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6bbv Homo sapiens TYR_JAK2-2_HUMAN TYR 6.1e-87 297.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6X8EA O60674 843 1130 1132.0 UWP:4000 Type1 Inactive DFGin 6.257 13.614 ABAminus -104.07, -6.27 -144.33, 140.78 -129.93, 25.98 299.29, 84.64 -56.68, -27.83 in-in in 8.514 Saltbr-in 2.77 HRD-in -64.77, -46.55 65.18, -3.57 in-in-none SNCiin in-none ActLoopNT-in 2.871 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.41 APE8-dihe-in -80.26, 70.05 APE8-rot-na 29.9 APE67-dihe-in -75.03, -3.98 -52.38, -33.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.218 M1073S,F1076T PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.75 0.183 0.225 A 298 274 14 0 0 4 [[545, 807], [849, 1125]] 2.0 6x8e Homo sapiens TYR_JAK2-2_HUMAN TYR 6.1e-87 297.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6X8EB O60674 843 1132 1132.0 UWP:4001 Type1 Inactive DFGin 6.233 13.721 ABAminus -106.05, -4.78 -145.1, 140.25 -129.47, 26.42 299.09, 84.77 -55.74, -27.96 in-in in 8.485 Saltbr-in 2.791 HRD-in -65.28, -46.37 65.46, -3.84 in-in-none SNCiin in-none ActLoopNT-in 2.89 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.68 APE8-dihe-in -81.95, 68.62 APE8-rot-na 30.25 APE67-dihe-in -74.54, -2.39 -53.13, -32.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.287 M1073S,F1076T PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.75 0.183 0.225 B 298 281 9 0 0 5 [[545, 807], [849, 1125]] 2.0 6x8e Homo sapiens TYR_JAK2-2_HUMAN TYR 6.1e-87 297.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 7LL5A O60674 840 1132 1132.0 Y5G:1202 Type1 Inactive DFGin 6.328 13.256 ABAminus -111.9, -9.06 -144.82, 143.7 -137.48, 34.37 299.16, 84.57 -71.01, -21.45 in-in in 8.545 Saltbr-in 2.896 HRD-in -71.87, -45.77 67.74, 6.24 in-in-in SNCiii in-in ActLoopNT-in 2.806 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -50.46, 104.84 APE9-dihe-in -121.67, 111.5 APE8-dihe-in -79.5, 76.19 APE8-rot-na 29.89 APE67-dihe-in -81.17, 1.75 -62.05, -27.41 APE12-dist-na 10.448 APE11-dist-na 9.962 APE10-dist-na 7.596 APE9-dist-in 6.877 None PTR1007 PTR1007 XRAY 1.5 0.196 0.221 A 293 291 2 0 0 0 [[545, 807], [849, 1125]] 2.0 7ll5 Homo sapiens TYR_JAK2-2_HUMAN TYR 2.4e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 2B7AA O60674 843 1132 1132.0 IZA:2001 Type1 Inactive DFGin 6.091 13.625 ABAminus -114.38, -2.16 -148.17, 146.16 -136.98, 30.75 299.01, 90.79 -59.91, -29.0 in-in in 8.569 Saltbr-in 2.706 HRD-in -66.9, -48.29 72.12, 2.52 in-in-in SNCiii in-in ActLoopNT-in 2.792 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.58, 136.09 APE9-dihe-in -109.08, 151.35 APE8-dihe-in -75.49, 67.84 APE8-rot-na 28.43 APE67-dihe-in -82.12, -0.33 -57.73, -26.93 APE12-dist-na 12.838 APE11-dist-na 12.784 APE10-dist-na 13.028 APE9-dist-in 7.774 N1129Q PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.0 0.211 0.249 A 293 286 4 0 0 0 [[545, 807], [849, 1125]] 2.0 2b7a Homo sapiens TYR_JAK2-2_HUMAN TYR 2.4e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 2B7AB O60674 840 1132 1132.0 IZA:2002 Type1 Inactive DFGin 6.344 13.996 ABAminus -119.31, 4.3 -151.2, 143.13 -134.49, 30.64 293.9, 87.84 -61.34, -27.31 in-in in 8.553 Saltbr-in 2.699 HRD-in -66.93, -45.51 70.91, -4.56 in-in-in SNCiii in-in ActLoopNT-in 2.753 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.16, 133.69 APE9-dihe-in -107.45, 143.93 APE8-dihe-in -73.92, 74.12 APE8-rot-na 26.37 APE67-dihe-in -82.73, -2.12 -60.01, -26.2 APE12-dist-na 12.455 APE11-dist-na 10.818 APE10-dist-na 12.443 APE9-dist-in 7.584 N1129Q PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.0 0.211 0.249 B 293 289 4 0 0 0 [[545, 807], [849, 1125]] 2.0 2b7a Homo sapiens TYR_JAK2-2_HUMAN TYR 2.4e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 3FUPA O60674 843 1132 1132.0 MI1:1 Type1 Inactive DFGin 6.225 13.432 ABAminus -116.05, -10.27 -157.31, 141.86 -130.25, 26.52 298.67, 97.27 -56.05, -29.03 in-in in 8.532 Saltbr-in 2.813 HRD-in -69.41, -60.51 90.73, 3.04 in-in-in SNCiii in-in ActLoopNT-in 2.788 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -103.46, 121.61 APE9-dihe-in -101.81, 146.65 APE8-dihe-in -75.99, 69.83 APE8-rot-na 29.05 APE67-dihe-in -81.62, -2.38 -64.51, -21.49 APE12-dist-na 12.388 APE11-dist-na 13.122 APE10-dist-na 12.928 APE9-dist-in 7.819 N1129Q PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.4 0.182 0.25 A 293 286 4 0 0 0 [[545, 807], [849, 1125]] 2.0 3fup Homo sapiens TYR_JAK2-2_HUMAN TYR 2.4e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 3FUPB O60674 840 1132 1132.0 MI1:1 Type1 Inactive DFGin 6.516 13.542 ABAminus -123.67, 7.61 -151.78, 141.72 -133.31, 23.64 288.75, 96.19 -52.65, -32.8 in-in in 8.296 Saltbr-in 2.807 HRD-in -70.48, -55.18 91.07, -4.94 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.61, 115.12 APE9-dihe-in -94.97, 142.02 APE8-dihe-in -78.58, 69.75 APE8-rot-na 27.0 APE67-dihe-in -74.68, 0.84 -67.13, -29.65 APE12-dist-na 12.756 APE11-dist-na 12.389 APE10-dist-na 12.223 APE9-dist-in 7.705 N1129Q PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.4 0.182 0.25 B 293 289 4 0 0 0 [[545, 807], [849, 1125]] 2.0 3fup Homo sapiens TYR_JAK2-2_HUMAN TYR 2.4e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4P7EA O60674 843 1132 1132.0 2HB:1201 Type1 Inactive DFGin 6.14 13.482 ABAminus -124.45, -1.38 -143.07, 141.76 -136.38, 26.63 297.22, 97.88 -60.6, -28.13 in-in in 8.576 Saltbr-in 2.596 HRD-in -75.55, -47.44 69.37, 3.54 in-in-in SNCiii in-in ActLoopNT-in 2.706 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -104.89, 108.67 APE9-dihe-in -96.54, 141.13 APE8-dihe-in -69.31, 68.63 APE8-rot-na 25.75 APE67-dihe-in -80.27, -1.15 -59.72, -27.17 APE12-dist-na 13.062 APE11-dist-na 13.134 APE10-dist-na 12.609 APE9-dist-in 7.859 N1129Q PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.4 0.208 0.267 A 293 283 7 0 0 0 [[545, 807], [849, 1125]] 2.0 4p7e Homo sapiens TYR_JAK2-2_HUMAN TYR 2.4e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4P7EB O60674 840 1132 1132.0 2HB:1201 Type1 Inactive DFGin 6.414 13.697 ABAminus -115.99, -1.13 -148.14, 134.17 -130.43, 26.77 296.67, 85.72 -57.74, -28.02 in-in in 8.328 Saltbr-in 2.808 HRD-in -72.77, -49.08 78.97, -6.71 in-in-in SNCiii in-in ActLoopNT-in 2.724 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.19, 157.28 APE9-dihe-in -129.69, 151.57 APE8-dihe-in -76.37, 70.24 APE8-rot-na 28.33 APE67-dihe-in -83.2, -2.9 -60.49, -24.42 APE12-dist-na 13.343 APE11-dist-na 11.61 APE10-dist-na 12.725 APE9-dist-in 7.656 N1129Q PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.4 0.208 0.267 B 293 287 6 0 0 0 [[545, 807], [849, 1125]] 2.0 4p7e Homo sapiens TYR_JAK2-2_HUMAN TYR 2.4e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 3E62A O60674 839 1131 1132.0 5B1:1 Type1 Inactive DFGin 6.204 13.533 ABAminus -117.43, -9.54 -145.14, 143.03 -133.21, 27.96 294.3, 93.66 -64.8, -25.71 in-in in 8.562 Saltbr-in 2.71 HRD-in -66.37, -48.89 71.77, -4.26 in-in-in SNCiii in-in ActLoopNT-in 2.769 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -57.69, 123.41 APE9-dihe-in -119.72, 132.2 APE8-dihe-in -80.32, 68.61 APE8-rot-na 30.21 APE67-dihe-in -75.98, -4.12 -58.29, -27.27 APE12-dist-na 11.194 APE11-dist-na 9.741 APE10-dist-na 10.153 APE9-dist-in 7.058 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.922 0.169 0.218 A 293 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 3e62 Homo sapiens TYR_JAK2-2_HUMAN TYR 2.4e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 3E63A O60674 840 1131 1132.0 5B2:1 Type1 Inactive DFGin 6.243 13.507 ABAminus -112.95, -9.31 -145.85, 144.31 -135.9, 32.26 296.11, 93.33 -65.62, -22.76 in-in in 8.52 Saltbr-in 2.697 HRD-in -68.9, -47.56 68.19, -1.26 in-in-in SNCiii in-in ActLoopNT-in 2.732 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -61.25, 121.51 APE9-dihe-in -116.29, 133.15 APE8-dihe-in -81.25, 66.79 APE8-rot-na 26.73 APE67-dihe-in -77.97, -4.82 -56.67, -25.73 APE12-dist-na 11.43 APE11-dist-na 9.917 APE10-dist-na 10.463 APE9-dist-in 7.097 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.9 0.203 0.263 A 293 292 0 0 0 0 [[545, 807], [849, 1125]] 2.0 3e63 Homo sapiens TYR_JAK2-2_HUMAN TYR 2.4e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 3E64A O60674 839 1131 1132.0 5B3:1 Type1 Inactive DFGin 6.29 13.426 ABAminus -117.76, -5.87 -147.76, 143.26 -133.0, 28.87 296.92, 93.43 -63.79, -22.59 in-in in 8.54 Saltbr-in 2.695 HRD-in -73.29, -45.29 66.18, -2.15 in-in-in SNCiii in-in ActLoopNT-in 2.766 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -57.84, 124.88 APE9-dihe-in -124.06, 129.84 APE8-dihe-in -80.32, 69.47 APE8-rot-na 30.73 APE67-dihe-in -74.18, -4.27 -57.31, -29.24 APE12-dist-na 11.552 APE11-dist-na 10.057 APE10-dist-na 10.46 APE9-dist-in 7.034 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.8 0.172 0.22 A 293 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 3e64 Homo sapiens TYR_JAK2-2_HUMAN TYR 2.4e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 3KRRA O60674 840 1131 1132.0 DQX:60001 Type1 Inactive DFGin 6.111 13.355 ABAminus -118.83, -1.24 -150.38, 145.98 -134.02, 25.36 296.32, 84.62 -62.03, -27.75 in-in in 8.472 Saltbr-in 2.657 HRD-in -68.72, -45.54 74.36, -23.06 in-in-in SNCiii in-in ActLoopNT-in 2.801 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -46.19, 121.88 APE9-dihe-in -140.07, 105.66 APE8-dihe-in -75.55, 70.84 APE8-rot-na 30.39 APE67-dihe-in -77.46, -5.4 -55.44, -28.31 APE12-dist-na 10.213 APE11-dist-na 10.037 APE10-dist-na 7.409 APE9-dist-in 7.271 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.8 0.169 0.206 A 295 292 0 0 0 0 [[545, 807], [849, 1125]] 2.0 3krr Homo sapiens TYR_JAK2-2_HUMAN TYR 2.5e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 3LPBA O60674 842 1131 1132.0 NVB:61133 Type1 Inactive DFGin 6.252 13.471 ABAminus -118.13, 3.49 -150.26, 140.34 -128.73, 24.71 296.89, 86.22 -55.47, -30.57 in-in in 8.552 Saltbr-in 2.58 HRD-in -69.29, -46.76 69.54, 5.53 in-in-in SNCiii in-in ActLoopNT-in 2.835 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.85, 115.06 APE9-dihe-in -78.93, 143.76 APE8-dihe-in -77.26, 67.49 APE8-rot-na 32.29 APE67-dihe-in -78.53, -4.63 -55.18, -29.06 APE12-dist-na 12.878 APE11-dist-na 11.685 APE10-dist-na 13.113 APE9-dist-in 7.912 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.0 0.178 0.207 A 295 280 10 0 0 0 [[545, 807], [849, 1125]] 2.0 3lpb Homo sapiens TYR_JAK2-2_HUMAN TYR 2.5e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 3LPBB O60674 840 1132 1132.0 NVB:61133 Type1 Inactive DFGin 6.414 13.631 ABAminus -111.19, 1.19 -153.19, 136.07 -126.66, 23.99 296.66, 80.96 -51.9, -31.54 in-in in 8.429 Saltbr-in 2.795 HRD-in -80.7, -45.59 69.18, -7.08 in-in-none SNCiin in-none ActLoopNT-in 2.716 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 123.25 APE9-dihe-in -129.24, 142.1 APE8-dihe-in -77.96, 73.49 APE8-rot-na 29.39 APE67-dihe-in -79.17, -1.43 -62.85, -28.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.981 APE9-dist-in 7.681 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.0 0.178 0.207 B 295 285 8 0 0 3 [[545, 807], [849, 1125]] 2.0 3lpb Homo sapiens TYR_JAK2-2_HUMAN TYR 2.5e-87 298.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 5TQ6A O60674 843 1132 1132.0 7GV:4000 Type1 Inactive DFGin 6.075 13.383 ABAminus -115.84, 4.11 -150.06, 142.11 -129.75, 33.22 297.27, 97.82 -62.11, -22.89 in-in in 8.508 Saltbr-in 2.584 HRD-in -72.1, -52.07 80.22, -10.44 in-in-none SNCiin in-none ActLoopNT-in 2.844 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 149.94 APE9-dihe-in -125.18, 149.33 APE8-dihe-in -73.55, 68.75 APE8-rot-na 30.87 APE67-dihe-in -75.64, -0.92 -63.35, -28.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.055 APE9-dist-in 7.93 M1073S,F1076T PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.06 0.259 0.289 A 304 276 14 0 0 3 [[545, 807], [849, 1125]] 2.0 5tq6 Homo sapiens TYR_JAK2-2_HUMAN TYR 6.6e-87 297.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 5TQ6B O60674 843 1130 1132.0 7GV:4001 Type1 Inactive DFGin 6.162 13.363 ABAminus -111.57, -0.99 -147.24, 140.21 -133.48, 34.47 301.56, 87.04 -70.04, -26.0 in-in in 8.402 Saltbr-in 2.86 HRD-in -64.79, -51.16 74.89, -3.31 in-in-none SNCiin in-none ActLoopNT-in 2.684 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.65 APE8-dihe-in -75.33, 63.27 APE8-rot-na 30.25 APE67-dihe-in -71.69, -0.6 -52.05, -37.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.965 M1073S,F1076T PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.06 0.259 0.289 B 304 273 15 0 0 4 [[545, 807], [849, 1125]] 2.0 5tq6 Homo sapiens TYR_JAK2-2_HUMAN TYR 6.6e-87 297.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 5TQ7A O60674 841 1132 1132.0 7GT:4000 Type1 Inactive DFGin 6.323 13.447 ABAminus -112.11, 6.39 -155.17, 139.89 -132.33, 31.13 301.67, 84.4 -54.42, -34.31 in-in in 8.227 Saltbr-in 2.596 HRD-in -76.61, -45.66 78.1, -8.67 in-in-none SNCiin in-none ActLoopNT-in 2.861 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 130.6 APE9-dihe-in -120.25, 145.22 APE8-dihe-in -82.11, 80.94 APE8-rot-na 32.95 APE67-dihe-in -75.04, -9.7 -64.29, -26.87 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.422 APE9-dist-in 7.681 M1073S,F1076T,I1126V PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.1 0.229 0.286 A 304 277 15 0 0 4 [[545, 807], [849, 1125]] 2.0 5tq7 Homo sapiens TYR_JAK2-2_HUMAN TYR 6.6e-87 297.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 5TQ7B O60674 843 1132 1132.0 7GT:4000 Type1 Inactive DFGin 6.107 13.502 ABAminus -110.47, 5.32 -145.71, 141.14 -137.73, 43.09 299.27, 79.83 -87.98, -15.69 in-in in 8.574 Saltbr-in 2.559 HRD-in -74.7, -41.33 71.59, -12.66 in-in-in SNCiii in-in ActLoopNT-in 2.859 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.68, 157.9 APE9-dihe-in -122.63, 153.25 APE8-dihe-in -77.9, 72.47 APE8-rot-na 30.75 APE67-dihe-in -86.98, 6.22 -56.6, -25.3 APE12-dist-na 999.0 APE11-dist-na 11.751 APE10-dist-na 12.452 APE9-dist-in 7.777 M1073S,F1076T,I1126V PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.1 0.229 0.286 B 304 271 19 0 0 3 [[545, 807], [849, 1125]] 2.0 5tq7 Homo sapiens TYR_JAK2-2_HUMAN TYR 6.6e-87 297.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 7LL4A O60674 839 1132 1132.0 Y5D:61201 Type1 Inactive DFGin 6.237 13.346 ABAminus -111.87, -12.4 -148.07, 145.73 -133.69, 26.5 295.72, 88.69 -63.44, -25.93 in-in in 8.56 Saltbr-in 2.871 HRD-in -74.77, -47.27 71.81, 2.5 in-in-in SNCiii in-in ActLoopNT-in 2.805 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.74, 124.43 APE9-dihe-in -118.12, 108.48 APE8-dihe-in -77.72, 77.11 APE8-rot-na 30.86 APE67-dihe-in -76.62, -3.15 -64.49, -27.35 APE12-dist-na 10.187 APE11-dist-na 8.934 APE10-dist-na 8.329 APE9-dist-in 7.019 None PTR1007 PTR1007 XRAY 1.31 0.178 0.194 A 297 294 0 0 0 0 [[545, 807], [849, 1125]] 2.0 7ll4 Homo sapiens TYR_JAK2-2_HUMAN TYR 2.5e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 7REEA O60674 839 1130 1132.0 4LY:61201 Type1 Inactive DFGin 6.288 13.336 ABAminus -111.29, -12.64 -147.41, 147.89 -137.15, 27.39 297.98, 85.55 -64.9, -23.25 in-in in 8.492 Saltbr-in 2.787 HRD-in -71.82, -48.68 71.66, 2.81 in-in-none SNCiin in-none ActLoopNT-in 2.809 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 113.93 APE8-dihe-in -75.76, 74.26 APE8-rot-na 30.49 APE67-dihe-in -80.67, 1.45 -60.2, -27.42 APE12-dist-na 11.193 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.133 None PTR1007 PTR1007 XRAY 1.38 0.174 0.205 A 297 288 4 0 0 2 [[545, 807], [849, 1125]] 2.0 7ree Homo sapiens TYR_JAK2-2_HUMAN TYR 2.5e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4D0WA O60674 839 1130 1132.0 VVQ:2132 Type1 Inactive DFGin 6.276 13.526 ABAminus -121.35, -5.98 -149.17, 146.15 -130.76, 29.34 294.02, 83.91 -68.32, -23.85 in-in in 8.427 Saltbr-in 2.822 HRD-in -68.34, -43.76 72.13, -8.84 in-in-in SNCiii in-in ActLoopNT-in 2.83 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.76, 138.61 APE9-dihe-in -136.68, 129.14 APE8-dihe-in -86.53, 73.15 APE8-rot-na 31.27 APE67-dihe-in -71.04, -8.89 -58.05, -27.58 APE12-dist-na 10.91 APE11-dist-na 9.679 APE10-dist-na 10.123 APE9-dist-in 7.038 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.77 0.175 0.215 A 298 291 1 0 0 0 [[545, 807], [849, 1125]] 2.0 4d0w Homo sapiens TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4D0XA O60674 839 1131 1132.0 953:2132 Type1 Inactive DFGin 6.176 13.315 ABAminus -120.48, -3.08 -149.35, 141.94 -130.69, 26.8 296.75, 85.48 -62.08, -25.74 in-in in 8.515 Saltbr-in 2.737 HRD-in -69.4, -46.22 76.98, -14.46 in-in-in SNCiii in-in ActLoopNT-in 2.83 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -45.33, 128.51 APE9-dihe-in -145.08, 109.4 APE8-dihe-in -86.52, 75.6 APE8-rot-na 31.86 APE67-dihe-in -75.53, -7.86 -59.36, -25.54 APE12-dist-na 10.423 APE11-dist-na 9.495 APE10-dist-na 7.147 APE9-dist-in 6.946 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.82 0.166 0.219 A 298 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4d0x Homo sapiens TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 5AEPA O60674 840 1131 1132.0 QUP:2000 Type1 Inactive DFGin 6.253 13.159 ABAminus -125.75, 4.32 -152.04, 146.73 -136.98, 29.7 294.69, 83.13 -68.44, -27.57 in-in in 8.435 Saltbr-in 2.848 HRD-in -64.03, -50.14 76.8, -15.41 in-in-in SNCiii in-in ActLoopNT-in 2.708 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -42.38, 127.98 APE9-dihe-in -145.32, 108.79 APE8-dihe-in -83.74, 73.12 APE8-rot-na 22.99 APE67-dihe-in -68.58, -7.69 -60.86, -27.68 APE12-dist-na 10.399 APE11-dist-na 9.306 APE10-dist-na 7.369 APE9-dist-in 7.021 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.95 0.173 0.213 A 298 289 3 0 0 0 [[545, 807], [849, 1125]] 2.0 5aep Homo sapiens TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 3TJCA O60674 843 1132 1132.0 0TP:1 Type1 Inactive DFGin 6.182 13.776 ABAminus -111.28, 8.43 -150.47, 142.92 -136.09, 31.13 297.77, 93.1 -58.92, -26.75 in-in in 8.633 Saltbr-in 2.701 HRD-in -58.35, -49.6 68.34, 2.22 in-in-in SNCiii in-in ActLoopNT-in 2.807 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.05, 136.72 APE9-dihe-in -111.73, 151.95 APE8-dihe-in -78.69, 64.15 APE8-rot-na 33.68 APE67-dihe-in -82.41, 8.52 -50.91, -27.5 APE12-dist-na 12.872 APE11-dist-na 12.665 APE10-dist-na 13.033 APE9-dist-in 7.847 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.4 0.265 0.275 A 298 286 4 0 0 0 [[545, 807], [849, 1125]] 2.0 3tjc Homo sapiens TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 3TJCB O60674 840 1132 1132.0 0TP:1 Type1 Inactive DFGin 6.383 14.126 ABAminus -116.85, 12.84 -151.32, 140.31 -135.01, 33.47 291.72, 91.04 -63.92, -25.01 in-in in 8.469 Saltbr-in 2.761 HRD-in -67.53, -45.4 67.54, -5.76 in-in-in SNCiii in-in ActLoopNT-in 2.726 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.38, 138.96 APE9-dihe-in -114.25, 144.01 APE8-dihe-in -76.43, 71.46 APE8-rot-na 32.78 APE67-dihe-in -82.33, 3.33 -53.44, -26.31 APE12-dist-na 12.464 APE11-dist-na 10.827 APE10-dist-na 12.41 APE9-dist-in 7.632 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.4 0.265 0.275 B 298 289 4 0 0 0 [[545, 807], [849, 1125]] 2.0 3tjc Homo sapiens TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 3TJDA O60674 843 1132 1132.0 6TP:1 Type1 Inactive DFGin 5.991 13.668 ABAminus -106.4, 6.86 -148.97, 135.33 -126.71, 31.52 298.26, 96.91 -65.03, -17.37 in-in in 8.661 Saltbr-in 2.405 HRD-in -60.32, -42.09 57.24, 2.17 in-in-in SNCiii in-in ActLoopNT-in 2.756 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.99, 136.33 APE9-dihe-in -114.67, 153.5 APE8-dihe-in -80.71, 62.46 APE8-rot-na 37.92 APE67-dihe-in -72.13, 9.26 -46.3, -36.88 APE12-dist-na 12.873 APE11-dist-na 12.766 APE10-dist-na 12.946 APE9-dist-in 7.834 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.9 0.286 0.312 A 298 286 4 0 0 0 [[545, 807], [849, 1125]] 2.0 3tjd Homo sapiens TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 3TJDB O60674 840 1132 1132.0 6TP:1 Type1 Inactive DFGin 6.389 13.998 ABAminus -115.4, 19.45 -153.78, 133.17 -126.99, 29.7 296.86, 92.39 -60.7, -23.46 in-in in 8.472 Saltbr-in 2.899 HRD-in -70.92, -38.15 64.72, -21.56 in-in-in SNCiii in-in ActLoopNT-in 2.808 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -58.27, 138.19 APE9-dihe-in -112.71, 149.09 APE8-dihe-in -82.04, 69.58 APE8-rot-na 37.61 APE67-dihe-in -79.66, -3.25 -52.11, -26.43 APE12-dist-na 12.399 APE11-dist-na 10.691 APE10-dist-na 12.313 APE9-dist-in 7.826 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.9 0.286 0.312 B 298 289 4 0 0 0 [[545, 807], [849, 1125]] 2.0 3tjd Homo sapiens TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4HGEA O60674 843 1132 1132.0 15V:1201 Type1 Inactive DFGin 6.12 13.322 ABAminus -121.19, -0.59 -151.44, 140.08 -132.37, 31.16 296.92, 93.91 -59.01, -29.78 in-in in 8.51 Saltbr-in 2.651 HRD-in -71.02, -46.89 72.34, 4.2 in-in-in SNCiii in-in ActLoopNT-in 2.816 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.36, 116.11 APE9-dihe-in -94.64, 140.5 APE8-dihe-in -78.26, 68.86 APE8-rot-na 33.18 APE67-dihe-in -79.92, -6.13 -58.48, -24.37 APE12-dist-na 13.133 APE11-dist-na 12.335 APE10-dist-na 12.614 APE9-dist-in 7.9 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.3 0.182 0.227 A 300 286 4 0 0 0 [[545, 807], [849, 1125]] 2.0 4hge Homo sapiens TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4HGEB O60674 839 1132 1132.0 15V:1201 Type1 Inactive DFGin 6.414 13.619 ABAminus -123.27, 3.39 -144.34, 141.84 -131.47, 30.21 289.8, 89.09 -61.76, -21.14 in-in in 8.47 Saltbr-in 2.755 HRD-in -75.48, -44.42 74.95, -13.38 in-in-in SNCiii in-in ActLoopNT-in 2.775 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -80.96, 159.38 APE9-dihe-in -121.56, 128.25 APE8-dihe-in -83.16, 76.08 APE8-rot-na 32.14 APE67-dihe-in -81.69, -3.64 -63.01, -27.28 APE12-dist-na 7.612 APE11-dist-na 9.196 APE10-dist-na 10.927 APE9-dist-in 7.57 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.3 0.182 0.227 B 300 290 4 0 0 0 [[545, 807], [849, 1125]] 2.0 4hge Homo sapiens TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4IVAA O60674 841 1132 1132.0 1J5:1201 Type1 Inactive DFGin 6.388 13.602 ABAminus -118.25, 0.69 -152.6, 145.56 -135.74, 29.43 296.04, 91.26 -62.02, -26.49 in-in in 8.14 Saltbr-in 2.66 HRD-in -71.64, -46.05 71.97, 4.91 in-in-in SNCiii in-in ActLoopNT-in 2.828 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.88, 157.47 APE9-dihe-in -148.23, 152.2 APE8-dihe-in -79.45, 71.02 APE8-rot-na 33.72 APE67-dihe-in -79.14, -1.96 -60.0, -26.54 APE12-dist-na 13.969 APE11-dist-na 13.082 APE10-dist-na 12.805 APE9-dist-in 7.824 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.5 0.176 0.193 A 300 292 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4iva Homo sapiens TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4JI9A O60674 843 1132 1132.0 1M3:1201 Type1 Inactive DFGin 6.324 13.484 ABAminus -109.55, -7.44 -150.82, 140.52 -127.26, 30.44 299.13, 87.76 -52.84, -40.14 in-in in 8.585 Saltbr-in 2.647 HRD-in -80.17, -42.61 76.43, -32.58 in-in-out SNCiio in-out ActLoopNT-in 2.752 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -82.23, 111.22 APE9-dihe-in -100.97, 137.91 APE8-dihe-in -72.06, 68.6 APE8-rot-na 27.55 APE67-dihe-in -77.94, 0.46 -63.88, -26.22 APE12-dist-na 13.441 APE11-dist-na 13.317 APE10-dist-na 13.32 APE9-dist-out 8.757 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.4 0.203 0.245 A 300 286 4 0 0 0 [[545, 807], [849, 1125]] 2.0 4ji9 Homo sapiens TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4JI9B O60674 839 1132 1132.0 1M3:1201 Type1 Inactive DFGin 6.466 13.849 ABAminus -116.52, -6.78 -147.24, 138.79 -124.56, 33.92 292.32, 86.1 -62.37, -34.07 in-in in 8.491 Saltbr-in 2.822 HRD-in -81.25, -47.33 75.7, -23.37 in-in-in SNCiii in-in ActLoopNT-in 2.697 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.22, 150.08 APE9-dihe-in -122.92, 128.48 APE8-dihe-in -79.58, 77.7 APE8-rot-na 25.7 APE67-dihe-in -82.32, 3.2 -61.18, -27.11 APE12-dist-na 8.057 APE11-dist-na 10.455 APE10-dist-na 11.075 APE9-dist-in 7.698 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.4 0.203 0.245 B 300 290 4 0 0 0 [[545, 807], [849, 1125]] 2.0 4ji9 Homo sapiens TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 3Q32A O60674 840 1132 1132.0 J2I:60001 Type1 Inactive DFGin 6.361 13.16 ABAminus -114.0, 9.8 -155.91, 140.25 -131.27, 26.73 299.78, 91.25 -53.97, -36.83 in-in in 8.507 Saltbr-in 2.734 HRD-in -67.89, -51.07 72.0, 2.71 in-in-in SNCiii in-in ActLoopNT-in 2.672 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.02, 124.49 APE9-dihe-in -104.36, 146.31 APE8-dihe-in -75.92, 65.47 APE8-rot-na 28.37 APE67-dihe-in -65.9, -9.93 -48.92, -44.51 APE12-dist-na 13.055 APE11-dist-na 12.866 APE10-dist-na 13.129 APE9-dist-in 7.929 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.5 0.178 0.21 A 301 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 3q32 Homo sapiens TYR_JAK2-2_HUMAN TYR 2.7e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 3Q32B O60674 839 1132 1132.0 J2I:60002 Type1 Inactive DFGin 6.567 13.418 ABAminus -99.13, -6.07 -150.2, 138.61 -127.33, 32.33 296.64, 91.2 -58.16, -35.1 in-in in 8.333 Saltbr-in 3.028 HRD-in -64.89, -50.46 73.01, -21.55 in-in-out SNCiio in-out ActLoopNT-in 2.727 ActLoopCT-out TYR APEdihe_ooiai APEdist_aaai APE10-dihe-out 54.05, -68.26 APE9-dihe-out 64.56, 127.18 APE8-dihe-in -78.63, 72.28 APE8-rot-na 27.75 APE67-dihe-in -79.48, -5.64 -54.11, -32.33 APE12-dist-na 10.429 APE11-dist-na 10.277 APE10-dist-na 11.348 APE9-dist-in 7.501 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.5 0.178 0.21 B 301 294 0 0 0 0 [[545, 807], [849, 1125]] 2.0 3q32 Homo sapiens TYR_JAK2-2_HUMAN TYR 2.7e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 5CF8A O60674 842 1132 1132.0 50V:64000 Type1 Inactive DFGin 6.319 13.61 ABAminus -111.5, 5.34 -159.98, 145.11 -133.05, 28.13 292.06, 92.11 -55.99, -28.41 in-in in 8.519 Saltbr-in 2.699 HRD-in -68.8, -45.07 66.6, 4.57 in-in-in SNCiii in-in ActLoopNT-in 2.807 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -84.77, 124.44 APE9-dihe-in -93.29, 144.71 APE8-dihe-in -78.53, 70.36 APE8-rot-na 30.49 APE67-dihe-in -76.87, -0.84 -55.83, -30.99 APE12-dist-na 12.946 APE11-dist-na 11.773 APE10-dist-na 12.808 APE9-dist-in 7.75 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.8 0.191 0.204 A 301 286 5 0 0 0 [[545, 807], [849, 1125]] 2.0 5cf8 Homo sapiens TYR_JAK2-2_HUMAN TYR 2.7e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 5CF8B O60674 839 1132 1132.0 50V:64000 Type1 Inactive DFGin 6.435 13.692 ABAminus -110.5, 4.8 -158.24, 144.72 -132.59, 27.56 291.52, 92.27 -58.53, -26.74 in-in in 8.453 Saltbr-in 2.731 HRD-in -69.62, -45.44 67.63, 3.37 in-in-out SNCiio in-out ActLoopNT-in 2.808 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 60.73, 91.69 APE9-dihe-in -118.13, 144.09 APE8-dihe-in -78.0, 69.71 APE8-rot-na 28.79 APE67-dihe-in -78.53, -1.18 -55.41, -30.41 APE12-dist-na 10.287 APE11-dist-na 11.081 APE10-dist-na 11.869 APE9-dist-in 7.744 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.8 0.191 0.204 B 301 289 5 0 0 0 [[545, 807], [849, 1125]] 2.0 5cf8 Homo sapiens TYR_JAK2-2_HUMAN TYR 2.7e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4AQCA O60674 842 1132 1132.0 88A:2001 Type1 Inactive DFGin 6.15 13.455 ABAminus -119.36, 0.46 -148.42, 139.35 -130.52, 29.8 295.81, 93.68 -57.31, -31.29 in-in in 8.588 Saltbr-in 2.64 HRD-in -68.43, -50.02 76.23, -1.23 in-in-in SNCiii in-in ActLoopNT-in 2.76 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.9, 129.7 APE9-dihe-in -107.31, 146.17 APE8-dihe-in -74.14, 67.42 APE8-rot-na 34.69 APE67-dihe-in -82.32, -4.12 -58.66, -24.6 APE12-dist-na 12.744 APE11-dist-na 12.838 APE10-dist-na 12.962 APE9-dist-in 7.816 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.9 0.178 0.217 A 301 291 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4aqc Homo sapiens TYR_JAK2-2_HUMAN TYR 2.7e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4AQCB O60674 836 1132 1132.0 88A:2001 Type1 Inactive DFGin 6.388 13.689 ABAminus -123.9, -2.65 -148.48, 139.47 -132.14, 28.65 294.89, 80.58 -66.71, -20.79 in-in in 8.457 Saltbr-in 2.638 HRD-in -71.57, -47.61 74.96, -4.96 in-in-in SNCiii in-in ActLoopNT-in 2.744 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.78, 150.42 APE9-dihe-in -118.99, 125.24 APE8-dihe-in -80.6, 74.92 APE8-rot-na 32.88 APE67-dihe-in -80.42, -6.59 -61.14, -25.41 APE12-dist-na 7.979 APE11-dist-na 9.467 APE10-dist-na 10.907 APE9-dist-in 7.626 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.9 0.178 0.217 B 301 297 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4aqc Homo sapiens TYR_JAK2-2_HUMAN TYR 2.7e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4F08A O60674 843 1132 1132.0 1RS:1201 Type1 Inactive DFGin 6.422 13.449 ABAminus -118.75, 17.84 -162.68, 140.07 -138.8, 36.17 302.12, 78.28 -60.82, -32.25 in-in in 8.347 Saltbr-in 2.96 HRD-in -65.4, -47.08 70.33, 4.13 in-in-in SNCiii in-in ActLoopNT-in 2.716 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.27, 131.17 APE9-dihe-in -120.61, 142.32 APE8-dihe-in -71.84, 61.3 APE8-rot-na 27.63 APE67-dihe-in -74.77, -5.24 -55.3, -29.19 APE12-dist-na 12.333 APE11-dist-na 13.397 APE10-dist-na 12.857 APE9-dist-in 7.956 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.82 0.214 0.241 A 302 290 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4f08 Homo sapiens TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4F08B O60674 843 1132 1132.0 1RS:1201 Type1 Inactive DFGin 6.516 13.42 ABAminus -124.31, 17.64 -159.69, 141.63 -138.77, 37.19 300.52, 77.4 -63.7, -27.82 in-in in 8.334 Saltbr-in 2.917 HRD-in -64.42, -45.84 68.41, 15.3 in-in-in SNCiii in-in ActLoopNT-in 2.724 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -58.79, 144.81 APE9-dihe-in -113.89, 127.58 APE8-dihe-in -71.3, 63.33 APE8-rot-na 27.17 APE67-dihe-in -75.09, -5.44 -57.05, -30.14 APE12-dist-na 8.12 APE11-dist-na 9.253 APE10-dist-na 11.287 APE9-dist-in 7.932 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.82 0.214 0.241 B 302 290 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4f08 Homo sapiens TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4F09A O60674 843 1132 1132.0 JAK:1201 Type1 Inactive DFGin 6.346 13.64 ABAminus -102.4, 3.93 -153.26, 137.83 -131.35, 32.59 302.39, 88.52 -60.65, -32.63 in-in in 8.192 Saltbr-in 2.72 HRD-in -66.03, -47.09 70.26, -3.17 in-in-in SNCiii in-in ActLoopNT-in 2.659 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.49, 147.17 APE9-dihe-in -131.9, 144.19 APE8-dihe-in -76.78, 68.09 APE8-rot-na 28.11 APE67-dihe-in -65.65, -9.03 -42.52, -43.38 APE12-dist-na 13.863 APE11-dist-na 13.083 APE10-dist-na 12.641 APE9-dist-in 7.809 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.4 0.198 0.254 A 302 290 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4f09 Homo sapiens TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4GFMA O60674 840 1130 1132.0 0X2:1201 Type1 Inactive DFGin 6.218 13.617 ABAminus -121.44, -7.12 -143.9, 139.81 -132.81, 29.99 295.23, 86.37 -67.0, -21.6 in-in in 8.42 Saltbr-in 3.064 HRD-in -69.73, -44.15 65.44, -8.11 in-in-in SNCiii in-in ActLoopNT-in 2.718 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.82, 128.5 APE9-dihe-in -126.85, 127.41 APE8-dihe-in -79.98, 73.49 APE8-rot-na 29.58 APE67-dihe-in -75.78, -2.18 -60.58, -27.16 APE12-dist-na 10.952 APE11-dist-na 9.716 APE10-dist-na 9.927 APE9-dist-in 7.029 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.3 0.171 0.242 A 302 291 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4gfm Homo sapiens TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 3RVGA O60674 841 1132 1132.0 17P:2000 Type1 Inactive DFGin 6.444 13.309 ABAminus -117.6, -0.24 -150.28, 146.04 -143.43, 33.28 298.77, 92.11 -68.51, -23.75 in-in in 8.454 Saltbr-in 2.496 HRD-in -62.82, -53.33 76.84, -7.61 in-in-none SNCiin in-none ActLoopNT-in 2.733 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -151.78 APE8-dihe-in -87.41, 90.65 APE8-rot-na 40.72 APE67-dihe-in -82.3, 0.9 -69.11, -22.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.738 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.498 0.225 0.3 A 303 287 5 0 0 5 [[545, 807], [849, 1125]] 2.0 3rvg Homo sapiens TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VGLA O60674 840 1132 1132.0 RXT:61201 Type1 Inactive DFGin 6.446 13.513 ABAminus -117.0, -7.21 -146.07, 141.05 -130.49, 28.54 292.94, 81.12 -65.56, -22.11 in-in in 8.428 Saltbr-in 2.754 HRD-in -71.73, -48.4 73.96, -1.64 in-in-in SNCiii in-in ActLoopNT-in 2.781 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -88.11, 129.62 APE9-dihe-in -121.72, 122.37 APE8-dihe-in -84.02, 76.32 APE8-rot-na 33.09 APE67-dihe-in -78.28, -3.75 -61.51, -29.27 APE12-dist-na 13.555 APE11-dist-na 9.49 APE10-dist-na 8.47 APE9-dist-in 7.051 None PTR1007 PTR1007 XRAY 1.9 0.182 0.217 A 308 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vgl Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VGLB O60674 840 1132 1132.0 RXT:61201 Type1 Inactive DFGin 6.445 13.616 ABAminus -116.85, -7.44 -149.05, 140.79 -130.84, 27.89 290.32, 82.4 -67.42, -21.82 in-in in 8.398 Saltbr-in 2.781 HRD-in -71.23, -46.75 71.83, -3.65 in-in-in SNCiii in-in ActLoopNT-in 2.815 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -93.23, 146.01 APE9-dihe-in -126.07, 123.7 APE8-dihe-in -81.61, 74.86 APE8-rot-na 31.65 APE67-dihe-in -77.61, -3.9 -60.75, -30.09 APE12-dist-na 13.288 APE11-dist-na 9.377 APE10-dist-na 8.665 APE9-dist-in 6.981 None PTR1007 PTR1007 XRAY 1.9 0.182 0.217 B 308 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vgl Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VGLC O60674 843 1131 1132.0 RXT:61201 Type1 Inactive DFGin 6.222 13.379 ABAminus -115.55, -9.12 -143.9, 140.61 -132.23, 26.54 293.7, 85.16 -65.11, -21.72 in-in in 8.417 Saltbr-in 2.704 HRD-in -73.34, -48.11 71.88, -3.21 in-in-in SNCiii in-in ActLoopNT-in 2.813 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.66, 127.53 APE9-dihe-in -113.0, 141.05 APE8-dihe-in -75.8, 72.0 APE8-rot-na 32.54 APE67-dihe-in -77.35, -4.0 -61.49, -27.59 APE12-dist-na 13.338 APE11-dist-na 13.082 APE10-dist-na 13.222 APE9-dist-in 7.904 None PTR1007 PTR1007 XRAY 1.9 0.182 0.217 C 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vgl Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VGLD O60674 843 1131 1132.0 RXT:61201 Type1 Inactive DFGin 6.288 13.488 ABAminus -116.23, -6.92 -148.77, 141.37 -133.22, 26.24 295.62, 83.68 -64.72, -19.37 in-in in 8.434 Saltbr-in 2.677 HRD-in -70.05, -46.57 72.2, -0.79 in-in-in SNCiii in-in ActLoopNT-in 2.763 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.83, 129.61 APE9-dihe-in -113.86, 144.08 APE8-dihe-in -77.54, 74.01 APE8-rot-na 34.3 APE67-dihe-in -79.99, -2.4 -62.52, -26.5 APE12-dist-na 13.31 APE11-dist-na 13.261 APE10-dist-na 13.273 APE9-dist-in 7.82 None PTR1007 PTR1007 XRAY 1.9 0.182 0.217 D 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vgl Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VN8A O60674 840 1132 1132.0 3JW:61201 Type1 Inactive DFGin 6.42 13.799 ABAminus -116.88, -11.5 -143.58, 137.54 -129.5, 26.21 292.83, 83.89 -62.24, -22.44 in-in in 8.581 Saltbr-in 2.751 HRD-in -74.45, -48.89 74.52, -4.46 in-in-in SNCiii in-in ActLoopNT-in 2.788 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.86, 136.24 APE9-dihe-in -126.34, 122.3 APE8-dihe-in -79.17, 73.44 APE8-rot-na 30.57 APE67-dihe-in -82.31, 0.54 -60.95, -23.7 APE12-dist-na 13.292 APE11-dist-na 9.326 APE10-dist-na 8.777 APE9-dist-in 6.956 None PTR1007 PTR1007 XRAY 1.9 0.185 0.215 A 308 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vn8 Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VN8B O60674 843 1131 1132.0 3JW:61201 Type1 Inactive DFGin 6.202 13.633 ABAminus -114.34, -11.39 -144.21, 140.62 -131.03, 26.72 294.72, 85.25 -60.7, -25.73 in-in in 8.616 Saltbr-in 2.632 HRD-in -74.15, -47.61 71.7, -1.3 in-in-in SNCiii in-in ActLoopNT-in 2.769 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.46, 140.77 APE9-dihe-in -119.45, 142.72 APE8-dihe-in -71.39, 69.25 APE8-rot-na 31.65 APE67-dihe-in -81.85, -1.4 -64.46, -21.62 APE12-dist-na 13.405 APE11-dist-na 12.858 APE10-dist-na 13.328 APE9-dist-in 7.896 None PTR1007 PTR1007 XRAY 1.9 0.185 0.215 B 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vn8 Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VNBA O60674 840 1132 1132.0 R6P:61201 Type1 Inactive DFGin 6.35 13.558 ABAminus -118.62, -19.62 -134.83, 143.12 -133.38, 24.47 298.28, 91.33 -62.05, -22.2 in-in in 8.704 Saltbr-in 3.038 HRD-in -74.06, -49.4 74.99, -5.13 in-in-in SNCiii in-in ActLoopNT-in 2.777 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.81, 144.4 APE9-dihe-in -128.3, 128.29 APE8-dihe-in -78.46, 78.55 APE8-rot-na 29.64 APE67-dihe-in -84.54, -4.75 -64.16, -21.71 APE12-dist-na 13.155 APE11-dist-na 9.378 APE10-dist-na 9.993 APE9-dist-in 6.925 None PTR1007 PTR1007 XRAY 2.19 0.217 0.261 A 308 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnb Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VNBB O60674 843 1131 1132.0 R6P:61201 Type1 Inactive DFGin 6.151 13.517 ABAminus -116.85, -18.84 -135.3, 144.45 -134.76, 23.18 296.23, 88.9 -62.89, -23.75 in-in in 8.742 Saltbr-in 2.835 HRD-in -73.15, -47.55 74.78, -6.06 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.7, 141.71 APE9-dihe-in -125.69, 135.6 APE8-dihe-in -71.63, 74.77 APE8-rot-na 30.51 APE67-dihe-in -85.73, -5.2 -67.19, -19.79 APE12-dist-na 13.148 APE11-dist-na 12.045 APE10-dist-na 12.948 APE9-dist-in 7.869 None PTR1007 PTR1007 XRAY 2.19 0.217 0.261 B 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnb Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VNCA O60674 840 1131 1132.0 R6V:61201 Type1 Inactive DFGin 6.175 13.178 ABAminus -125.0, 1.92 -144.44, 138.94 -134.55, 26.62 299.16, 82.3 -63.96, -13.53 in-in in 8.732 Saltbr-in 3.231 HRD-in -71.26, -46.55 70.57, -1.02 in-in-in SNCiii in-in ActLoopNT-in 2.753 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.44, 156.2 APE9-dihe-in -132.4, 123.78 APE8-dihe-in -79.65, 76.35 APE8-rot-na 29.35 APE67-dihe-in -79.45, -6.71 -61.99, -27.52 APE12-dist-na 12.877 APE11-dist-na 8.486 APE10-dist-na 9.116 APE9-dist-in 6.852 None PTR1007 PTR1007 XRAY 2.3 0.227 0.269 A 308 292 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnc Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VNCB O60674 843 1131 1132.0 R6V:61201 Type1 Inactive DFGin 6.154 13.17 ABAminus -122.12, 1.77 -145.07, 140.87 -135.43, 27.24 299.55, 83.32 -63.99, -17.1 in-in in 8.871 Saltbr-in 2.922 HRD-in -71.34, -45.2 70.18, -2.12 in-in-in SNCiii in-in ActLoopNT-in 2.751 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.37, 171.08 APE9-dihe-in -127.34, 149.39 APE8-dihe-in -72.05, 74.05 APE8-rot-na 32.11 APE67-dihe-in -79.07, -5.61 -65.16, -22.9 APE12-dist-na 12.808 APE11-dist-na 12.821 APE10-dist-na 13.914 APE9-dist-in 7.934 None PTR1007 PTR1007 XRAY 2.3 0.227 0.269 B 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnc Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VNEA O60674 840 1131 1132.0 2TA:1201 Type1 Inactive DFGin 6.24 13.55 ABAminus -112.42, -11.2 -144.98, 141.53 -127.78, 32.23 299.17, 89.49 -63.48, -25.65 in-in in 8.665 Saltbr-in 3.036 HRD-in -73.58, -49.14 71.52, -8.03 in-in-in SNCiii in-in ActLoopNT-in 2.828 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.09, 122.45 APE9-dihe-in -105.67, 157.15 APE8-dihe-in -76.97, 84.95 APE8-rot-na 28.57 APE67-dihe-in -90.04, 0.84 -78.4, -8.76 APE12-dist-na 9.559 APE11-dist-na 10.649 APE10-dist-na 13.363 APE9-dist-in 7.541 None PTR1007 PTR1007 XRAY 2.32 0.218 0.256 A 308 292 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vne Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VNEB O60674 843 1131 1132.0 2TA:1201 Type1 Inactive DFGin 6.117 13.225 ABAminus -110.41, -14.18 -143.68, 142.64 -126.91, 32.7 300.48, 90.31 -63.79, -30.1 in-in in 8.677 Saltbr-in 2.484 HRD-in -71.56, -46.99 72.0, -8.33 in-in-out SNCiio in-out ActLoopNT-in 2.815 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -93.72, 133.02 APE9-dihe-in -103.49, 156.39 APE8-dihe-in -78.16, 83.6 APE8-rot-na 32.04 APE67-dihe-in -91.27, 0.43 -78.58, -6.63 APE12-dist-na 13.225 APE11-dist-na 13.061 APE10-dist-na 14.217 APE9-dist-out 8.301 None PTR1007 PTR1007 XRAY 2.32 0.218 0.256 B 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vne Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VNFA O60674 840 1132 1132.0 R6S:61201 Type1 Inactive DFGin 6.401 13.602 ABAminus -118.43, -3.64 -151.35, 141.65 -132.21, 29.14 295.59, 85.58 -63.11, -24.0 in-in in 8.575 Saltbr-in 2.971 HRD-in -72.52, -45.08 76.22, -28.49 in-in-in SNCiii in-in ActLoopNT-in 2.846 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.59, 126.97 APE9-dihe-in -119.09, 117.22 APE8-dihe-in -78.88, 74.74 APE8-rot-na 28.3 APE67-dihe-in -82.18, -0.54 -60.56, -26.17 APE12-dist-na 13.628 APE11-dist-na 9.993 APE10-dist-na 8.563 APE9-dist-in 7.384 None PTR1007 PTR1007 XRAY 2.06 0.194 0.222 A 308 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnf Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VNFB O60674 841 1131 1132.0 R6S:61201 Type1 Inactive DFGin 6.135 13.537 ABAminus -117.95, -1.25 -153.05, 143.83 -133.46, 28.47 293.84, 87.12 -62.91, -26.87 in-in in 8.658 Saltbr-in 2.815 HRD-in -75.84, -43.4 73.32, -33.47 in-in-out SNCiio in-out ActLoopNT-in 2.782 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -86.85, 129.3 APE9-dihe-in -107.76, 138.95 APE8-dihe-in -69.74, 71.65 APE8-rot-na 30.42 APE67-dihe-in -79.11, -3.05 -64.43, -23.08 APE12-dist-na 13.104 APE11-dist-na 12.478 APE10-dist-na 13.657 APE9-dist-out 8.756 None PTR1007 PTR1007 XRAY 2.06 0.194 0.222 B 308 291 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnf Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VNGA O60674 841 1132 1132.0 R6M:1201 Type1 Inactive DFGin 6.284 13.57 ABAminus -121.14, 0.07 -154.35, 134.43 -129.13, 26.03 303.3, 79.75 -62.14, -18.06 in-in in 8.525 Saltbr-in 2.724 HRD-in -71.67, -45.35 75.28, -26.53 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -150.97, 166.68 APE9-dihe-in -128.34, 153.91 APE8-dihe-in -88.8, 83.93 APE8-rot-na 25.03 APE67-dihe-in -83.51, 0.54 -62.02, -27.23 APE12-dist-na 13.157 APE11-dist-na 10.042 APE10-dist-na 11.299 APE9-dist-in 7.281 None PTR1007 PTR1007 XRAY 2.5 0.213 0.251 A 308 292 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vng Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VNGB O60674 843 1131 1132.0 R6M:1201 Type1 Inactive DFGin 6.084 13.441 ABAminus -119.47, 1.55 -153.39, 138.22 -129.51, 27.29 300.51, 84.65 -62.17, -19.61 in-in in 8.541 Saltbr-in 2.525 HRD-in -72.31, -45.0 74.08, -28.57 in-in-out SNCiio in-out ActLoopNT-in 2.912 ActLoopCT-out TYR APEdihe_ioiai APEdist_aaai APE10-dihe-in -151.17, 167.67 APE9-dihe-out -117.53, -162.05 APE8-dihe-in -85.16, 86.67 APE8-rot-na 28.85 APE67-dihe-in -81.37, 0.25 -61.69, -27.42 APE12-dist-na 13.199 APE11-dist-na 12.813 APE10-dist-na 13.033 APE9-dist-in 7.766 None PTR1007 PTR1007 XRAY 2.5 0.213 0.251 B 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vng Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VNHA O60674 840 1132 1132.0 XZS:61201 Type1 Inactive DFGin 6.184 13.553 ABAminus -123.6, 24.97 -161.82, 132.95 -130.5, 37.69 300.8, 91.36 -67.84, -25.06 in-in in 8.429 Saltbr-in 2.79 HRD-in -79.9, -37.99 68.88, -41.62 in-in-in SNCiii in-in ActLoopNT-in 2.842 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.96, 147.55 APE9-dihe-in -142.31, 115.2 APE8-dihe-in -71.26, 87.66 APE8-rot-na 26.81 APE67-dihe-in -79.29, -8.01 -67.64, -27.75 APE12-dist-na 13.161 APE11-dist-na 9.563 APE10-dist-na 9.24 APE9-dist-in 7.563 None PTR1007 PTR1007 XRAY 2.4 0.231 0.267 A 308 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnh Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VNHB O60674 843 1131 1132.0 XZS:61201 Type1 Inactive DFGin 5.985 13.692 ABAminus -107.49, 3.1 -151.23, 145.03 -137.2, 27.68 297.12, 87.64 -65.09, -22.9 in-in in 8.702 Saltbr-in 2.567 HRD-in -73.62, -34.79 67.37, -46.78 in-in-out SNCiio in-out ActLoopNT-in 2.897 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -67.53, 130.24 APE9-dihe-in -117.53, 132.31 APE8-dihe-in -69.15, 74.29 APE8-rot-na 26.97 APE67-dihe-in -84.52, -2.56 -66.6, -16.86 APE12-dist-na 13.295 APE11-dist-na 12.384 APE10-dist-na 12.816 APE9-dist-out 8.873 None PTR1007 PTR1007 XRAY 2.4 0.231 0.267 B 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnh Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VNIA O60674 842 1132 1132.0 R61:1201 Type1 Inactive DFGin 6.372 13.893 ABAminus -132.82, -5.88 -134.64, 102.29 -105.41, 22.74 292.04, 85.81 -67.02, -17.75 in-in in 8.424 Saltbr-in 3.115 HRD-in -73.15, -47.37 76.86, -9.59 in-in-in SNCiii in-in ActLoopNT-in 2.801 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.58, 161.49 APE9-dihe-in -125.11, 123.14 APE8-dihe-in -78.8, 73.35 APE8-rot-na 30.02 APE67-dihe-in -81.16, -2.43 -62.36, -24.99 APE12-dist-na 12.841 APE11-dist-na 9.238 APE10-dist-na 10.179 APE9-dist-in 7.245 None PTR1007 PTR1007 XRAY 2.1 0.215 0.257 A 308 291 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vni Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VNIB O60674 843 1131 1132.0 R61:1201 Type1 Inactive DFGin 6.265 13.847 ABAminus -131.4, -8.41 -135.18, 107.42 -105.53, 24.3 291.29, 84.71 -65.51, -19.14 in-in in 8.554 Saltbr-in 2.409 HRD-in -72.62, -46.4 76.72, -7.82 in-in-out SNCiio in-out ActLoopNT-in 2.851 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -99.99, 151.02 APE9-dihe-in -125.21, 137.98 APE8-dihe-in -70.39, 70.81 APE8-rot-na 33.16 APE67-dihe-in -80.33, -2.36 -65.48, -23.28 APE12-dist-na 13.019 APE11-dist-na 11.819 APE10-dist-na 13.639 APE9-dist-out 8.158 None PTR1007 PTR1007 XRAY 2.1 0.215 0.257 B 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vni Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VNJA O60674 840 1132 1132.0 R5S:61201 Type1 Inactive DFGin 6.357 13.714 ABAminus -118.92, -6.85 -149.35, 132.07 -126.54, 24.6 294.41, 81.95 -61.91, -21.92 in-in in 8.624 Saltbr-in 2.76 HRD-in -73.19, -45.71 72.13, -3.37 in-in-in SNCiii in-in ActLoopNT-in 2.739 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.52, 135.78 APE9-dihe-in -128.55, 123.44 APE8-dihe-in -79.62, 75.87 APE8-rot-na 30.22 APE67-dihe-in -81.34, -2.92 -63.1, -25.95 APE12-dist-na 13.398 APE11-dist-na 9.488 APE10-dist-na 9.225 APE9-dist-in 7.102 None PTR1007 PTR1007 XRAY 1.9 0.185 0.211 A 308 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnj Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VNJB O60674 842 1131 1132.0 R5S:61201 Type1 Inactive DFGin 6.205 13.567 ABAminus -116.85, -5.7 -149.84, 134.43 -128.79, 24.08 295.94, 84.61 -61.54, -23.54 in-in in 8.592 Saltbr-in 2.527 HRD-in -73.0, -46.01 70.61, -2.12 in-in-in SNCiii in-in ActLoopNT-in 2.733 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.48, 144.02 APE9-dihe-in -116.33, 142.06 APE8-dihe-in -73.73, 71.42 APE8-rot-na 32.45 APE67-dihe-in -82.06, -3.3 -62.97, -22.66 APE12-dist-na 13.304 APE11-dist-na 12.557 APE10-dist-na 13.498 APE9-dist-in 7.849 None PTR1007 PTR1007 XRAY 1.9 0.185 0.211 B 308 290 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnj Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VNKA O60674 840 1132 1132.0 RXT:61201 Type1 Inactive DFGin 6.346 13.504 ABAminus -115.53, -9.34 -146.7, 139.79 -130.65, 29.08 297.41, 82.92 -64.51, -25.93 in-in in 8.37 Saltbr-in 2.823 HRD-in -72.4, -46.44 73.38, -6.51 in-in-in SNCiii in-in ActLoopNT-in 2.748 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.17, 138.86 APE9-dihe-in -125.9, 117.8 APE8-dihe-in -77.19, 70.99 APE8-rot-na 34.11 APE67-dihe-in -82.04, -0.49 -60.88, -24.48 APE12-dist-na 13.289 APE11-dist-na 9.078 APE10-dist-na 8.5 APE9-dist-in 6.887 None PTR1007 PTR1007 XRAY 2.0 0.219 0.244 A 308 292 1 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnk Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VNKB O60674 840 1132 1132.0 RXT:61201 Type1 Inactive DFGin 6.484 13.471 ABAminus -114.35, -10.36 -144.27, 138.95 -130.65, 27.3 296.72, 80.78 -63.16, -24.64 in-in in 8.645 Saltbr-in 2.956 HRD-in -76.05, -48.13 73.42, -7.36 in-in-in SNCiii in-in ActLoopNT-in 2.805 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.22, 137.32 APE9-dihe-in -130.36, 114.06 APE8-dihe-in -78.87, 73.36 APE8-rot-na 31.4 APE67-dihe-in -82.55, -2.95 -58.49, -25.22 APE12-dist-na 13.259 APE11-dist-na 9.498 APE10-dist-na 8.289 APE9-dist-in 6.947 None PTR1007 PTR1007 XRAY 2.0 0.219 0.244 B 308 292 1 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnk Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VNKC O60674 843 1131 1132.0 RXT:61201 Type1 Inactive DFGin 6.298 13.465 ABAminus -116.4, -8.39 -145.93, 138.87 -131.99, 24.75 293.4, 87.91 -62.13, -24.17 in-in in 8.433 Saltbr-in 2.775 HRD-in -70.05, -46.67 72.0, -3.71 in-in-out SNCiio in-out ActLoopNT-in 2.675 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -53.68, 136.82 APE9-dihe-in -128.24, 127.1 APE8-dihe-in -70.94, 70.21 APE8-rot-na 30.43 APE67-dihe-in -80.64, -2.41 -62.95, -22.96 APE12-dist-na 13.512 APE11-dist-na 12.93 APE10-dist-na 12.063 APE9-dist-out 8.085 None PTR1007 PTR1007 XRAY 2.0 0.219 0.244 C 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnk Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VNKD O60674 843 1131 1132.0 RXT:61201 Type1 Inactive DFGin 6.112 13.457 ABAminus -114.41, -10.28 -145.24, 140.17 -129.26, 27.8 295.47, 88.05 -63.2, -27.61 in-in in 8.501 Saltbr-in 2.688 HRD-in -73.35, -47.11 71.95, -9.02 in-in-in SNCiii in-in ActLoopNT-in 2.72 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.65, 135.59 APE9-dihe-in -122.99, 135.75 APE8-dihe-in -71.71, 68.28 APE8-rot-na 32.34 APE67-dihe-in -81.87, -2.23 -61.51, -23.34 APE12-dist-na 13.283 APE11-dist-na 12.874 APE10-dist-na 12.716 APE9-dist-in 7.747 None PTR1007 PTR1007 XRAY 2.0 0.219 0.244 D 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnk Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VNLA O60674 840 1132 1132.0 5W2:61201 Type1 Inactive DFGin 6.327 13.77 ABAminus -119.32, -0.49 -140.7, 133.57 -134.25, 25.52 297.74, 87.39 -65.79, -22.82 in-in in 8.396 Saltbr-in 2.695 HRD-in -67.09, -49.12 77.88, -9.34 in-in-in SNCiii in-in ActLoopNT-in 2.772 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.51, 153.05 APE9-dihe-in -134.74, 140.01 APE8-dihe-in -75.65, 76.24 APE8-rot-na 30.79 APE67-dihe-in -80.53, -2.68 -63.26, -24.89 APE12-dist-na 9.545 APE11-dist-na 10.935 APE10-dist-na 12.071 APE9-dist-in 7.676 None PTR1007 PTR1007 XRAY 2.4 0.218 0.257 A 308 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnl Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VNLB O60674 840 1132 1132.0 5W2:61201 Type1 Inactive DFGin 6.267 13.703 ABAminus -120.39, -1.24 -140.56, 133.69 -134.27, 25.09 300.22, 88.0 -65.36, -23.57 in-in in 8.35 Saltbr-in 2.485 HRD-in -66.32, -49.37 78.14, -8.52 in-in-in SNCiii in-in ActLoopNT-in 2.862 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.03, 146.85 APE9-dihe-in -140.64, 128.61 APE8-dihe-in -81.75, 76.62 APE8-rot-na 30.24 APE67-dihe-in -80.98, -3.76 -62.39, -26.5 APE12-dist-na 8.506 APE11-dist-na 9.941 APE10-dist-na 8.971 APE9-dist-in 6.989 None PTR1007 PTR1007 XRAY 2.4 0.218 0.257 B 308 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnl Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VNLC O60674 842 1131 1132.0 5W2:61201 Type1 Inactive DFGin 6.034 13.446 ABAminus -118.65, -2.25 -143.32, 137.65 -132.09, 28.15 298.49, 86.48 -64.1, -24.5 in-in in 8.587 Saltbr-in 2.629 HRD-in -67.65, -48.53 76.35, -9.72 in-in-out SNCiio in-out ActLoopNT-in 2.829 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -78.17, 150.96 APE9-dihe-in -134.19, 139.06 APE8-dihe-in -75.25, 71.72 APE8-rot-na 30.81 APE67-dihe-in -79.64, -2.96 -65.81, -24.18 APE12-dist-na 13.37 APE11-dist-na 12.542 APE10-dist-na 13.321 APE9-dist-out 8.458 None PTR1007 PTR1007 XRAY 2.4 0.218 0.257 C 308 290 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnl Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VNLD O60674 843 1131 1132.0 5W2:61201 Type1 Inactive DFGin 6.125 13.445 ABAminus -118.2, -3.11 -143.32, 139.15 -131.54, 28.79 298.46, 86.52 -63.72, -23.5 in-in in 8.453 Saltbr-in 2.499 HRD-in -67.45, -48.99 77.0, -9.54 in-in-out SNCiio in-out ActLoopNT-in 2.925 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -71.97, 152.24 APE9-dihe-in -132.29, 144.67 APE8-dihe-in -70.93, 73.22 APE8-rot-na 30.09 APE67-dihe-in -80.02, -3.29 -64.41, -24.13 APE12-dist-na 13.607 APE11-dist-na 12.431 APE10-dist-na 13.393 APE9-dist-out 8.045 None PTR1007 PTR1007 XRAY 2.4 0.218 0.257 D 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnl Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VNMA O60674 840 1132 1132.0 R5Y:61201 Type1 Inactive DFGin 6.276 13.856 ABAminus -161.76, 45.15 -147.28, 91.94 -100.3, 24.04 301.04, 88.04 -66.18, -22.04 in-in in 8.445 Saltbr-in 2.795 HRD-in -70.38, -47.67 75.09, -3.21 in-in-in SNCiii in-in ActLoopNT-in 2.846 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.31, 147.1 APE9-dihe-in -133.78, 127.05 APE8-dihe-in -79.36, 82.18 APE8-rot-na 30.27 APE67-dihe-in -79.86, -2.09 -63.93, -27.28 APE12-dist-na 13.16 APE11-dist-na 9.337 APE10-dist-na 9.9 APE9-dist-in 7.078 None PTR1007 PTR1007 XRAY 2.2 0.2 0.238 A 308 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnm Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VNMB O60674 843 1131 1132.0 R5Y:61201 Type1 Inactive DFGin 6.181 13.729 ABAminus -117.34, 7.17 -155.1, 140.98 -137.24, 30.83 296.86, 88.07 -64.53, -27.32 in-in in 8.498 Saltbr-in 2.667 HRD-in -72.3, -46.39 69.83, 0.54 in-in-in SNCiii in-in ActLoopNT-in 2.84 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.62, 127.37 APE9-dihe-in -107.62, 146.18 APE8-dihe-in -72.44, 70.75 APE8-rot-na 28.98 APE67-dihe-in -82.72, -2.53 -66.0, -19.57 APE12-dist-na 13.114 APE11-dist-na 12.515 APE10-dist-na 13.195 APE9-dist-in 7.954 None PTR1007 PTR1007 XRAY 2.2 0.2 0.238 B 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnm Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VS3A O60674 843 1131 1132.0 R6V:61201 Type1 Inactive DFGin 6.172 13.4 ABAminus -113.69, -9.73 -145.44, 139.92 -129.95, 28.79 298.53, 82.06 -63.1, -23.05 in-in in 8.628 Saltbr-in 2.665 HRD-in -70.46, -47.53 70.83, 1.7 in-in-in SNCiii in-in ActLoopNT-in 2.716 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.96, 143.74 APE9-dihe-in -124.34, 136.67 APE8-dihe-in -71.53, 71.61 APE8-rot-na 30.56 APE67-dihe-in -80.97, -2.5 -64.33, -23.02 APE12-dist-na 13.534 APE11-dist-na 12.192 APE10-dist-na 12.955 APE9-dist-in 7.731 None PTR1007 PTR1007 XRAY 2.0 0.186 0.218 A 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vs3 Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VS3B O60674 840 1132 1132.0 R6V:61201 Type1 Inactive DFGin 6.448 13.651 ABAminus -115.02, -9.81 -144.91, 138.32 -130.18, 30.61 296.48, 83.03 -64.54, -21.19 in-in in 8.591 Saltbr-in 2.758 HRD-in -72.75, -48.7 73.41, 1.11 in-in-in SNCiii in-in ActLoopNT-in 2.792 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.71, 137.37 APE9-dihe-in -128.13, 115.26 APE8-dihe-in -80.11, 76.19 APE8-rot-na 29.15 APE67-dihe-in -81.55, -1.54 -62.24, -25.56 APE12-dist-na 13.482 APE11-dist-na 9.569 APE10-dist-na 8.843 APE9-dist-in 6.816 None PTR1007 PTR1007 XRAY 2.0 0.186 0.218 B 308 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vs3 Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VSNA O60674 840 1132 1132.0 RG4:61201 Type1 Inactive DFGin 6.387 13.682 ABAminus -109.72, -15.97 -143.49, 135.23 -126.22, 34.01 297.74, 73.77 -69.3, -17.68 in-in in 8.481 Saltbr-in 2.897 HRD-in -79.84, -47.55 78.38, -6.15 in-in-in SNCiii in-in ActLoopNT-in 2.801 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.38, 157.36 APE9-dihe-in -150.13, 136.5 APE8-dihe-in -88.29, 86.0 APE8-rot-na 31.5 APE67-dihe-in -79.48, -1.84 -66.44, -27.63 APE12-dist-na 13.264 APE11-dist-na 9.454 APE10-dist-na 9.789 APE9-dist-in 7.435 None PTR1007 PTR1007 XRAY 2.5 0.192 0.252 A 308 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vsn Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VSNB O60674 842 1132 1132.0 RG4:61201 Type1 Inactive DFGin 6.533 13.616 ABAminus -117.93, -12.97 -144.23, 143.5 -132.58, 27.03 294.85, 82.1 -60.37, -24.95 in-in in 8.466 Saltbr-in 2.762 HRD-in -69.1, -47.38 74.26, -2.29 in-in-in SNCiii in-in ActLoopNT-in 2.732 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -88.77, 141.32 APE9-dihe-in -136.93, 114.67 APE8-dihe-in -78.68, 76.58 APE8-rot-na 34.47 APE67-dihe-in -78.91, -4.45 -63.01, -29.1 APE12-dist-na 13.466 APE11-dist-na 9.67 APE10-dist-na 8.649 APE9-dist-in 6.927 None PTR1007 PTR1007 XRAY 2.5 0.192 0.252 B 308 291 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vsn Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VSNC O60674 843 1131 1132.0 RG4:61201 Type1 Inactive DFGin 6.034 13.511 ABAminus -107.84, -22.28 -138.6, 146.61 -138.13, 17.5 291.81, 81.19 -54.12, -30.2 in-in in 8.404 Saltbr-in 2.811 HRD-in -72.34, -46.8 72.49, -7.83 in-in-in SNCiii in-in ActLoopNT-in 2.793 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.1, 144.23 APE9-dihe-in -124.87, 143.11 APE8-dihe-in -74.05, 69.35 APE8-rot-na 33.67 APE67-dihe-in -74.69, -6.91 -60.31, -31.34 APE12-dist-na 13.033 APE11-dist-na 12.562 APE10-dist-na 12.591 APE9-dist-in 7.777 None PTR1007 PTR1007 XRAY 2.5 0.192 0.252 C 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vsn Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6VSND O60674 843 1131 1132.0 RG4:61201 Type1 Inactive DFGin 6.309 13.563 ABAminus -113.0, -18.77 -145.19, 142.86 -134.87, 26.72 297.57, 84.55 -62.91, -20.18 in-in in 8.393 Saltbr-in 2.584 HRD-in -70.27, -45.5 73.77, -2.2 in-in-in SNCiii in-in ActLoopNT-in 2.795 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.43, 138.88 APE9-dihe-in -113.67, 149.04 APE8-dihe-in -68.65, 67.63 APE8-rot-na 29.35 APE67-dihe-in -83.91, -0.02 -57.93, -26.65 APE12-dist-na 13.214 APE11-dist-na 12.023 APE10-dist-na 12.863 APE9-dist-in 7.846 None PTR1007 PTR1007 XRAY 2.5 0.192 0.252 D 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vsn Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6WTNA O60674 843 1132 1132.0 RXT:61204 Type1 Inactive DFGin 6.303 13.472 ABAminus -111.65, -11.4 -144.34, 142.04 -130.65, 26.85 297.43, 84.86 -63.08, -21.36 in-in in 8.376 Saltbr-in 2.731 HRD-in -72.34, -45.85 71.67, 3.57 in-in-none SNCiin in-none ActLoopNT-in 2.822 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 99.29 APE9-dihe-in -135.56, 143.51 APE8-dihe-in -77.16, 75.07 APE8-rot-na 31.93 APE67-dihe-in -77.79, -2.65 -63.55, -26.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.496 APE9-dist-in 7.601 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.83 0.188 0.208 A 309 284 6 0 0 4 [[545, 807], [849, 1125]] 2.0 6wtn Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6WTOA O60674 843 1132 1132.0 3JW:61203 Type1 Inactive DFGin 6.295 13.728 ABAminus -110.91, -10.94 -144.37, 142.6 -132.91, 28.16 294.42, 82.44 -64.81, -24.56 in-in in 8.777 Saltbr-in 2.859 HRD-in -75.59, -46.13 71.34, -0.4 in-in-none SNCiin in-none ActLoopNT-in 2.874 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 111.14 APE8-dihe-in -79.27, 79.05 APE8-rot-na 31.58 APE67-dihe-in -75.7, -0.19 -66.04, -26.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.373 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.74 0.198 0.218 A 309 277 13 0 0 4 [[545, 807], [849, 1125]] 2.0 6wto Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6WTPA O60674 844 1132 1132.0 U8P:61201 Type1 Inactive DFGin 6.337 13.488 ABAminus -105.78, -9.61 -139.27, 143.87 -139.06, 28.68 303.29, 89.31 -68.12, -18.66 in-in in 8.834 Saltbr-in 2.731 HRD-in -70.88, -49.52 74.24, 2.12 in-in-none SNCiin in-none ActLoopNT-in 2.912 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 144.61 APE8-dihe-in -75.02, 77.35 APE8-rot-na 29.42 APE67-dihe-in -78.13, 0.58 -67.05, -26.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.762 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.5 0.24 0.288 A 309 275 12 0 0 6 [[545, 807], [849, 1125]] 2.0 6wtp Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6WTQA O60674 849 1132 1132.0 U8J:61201 Type1 Inactive DFGin 6.372 13.722 ABAminus -122.37, -1.18 -147.37, 138.84 -128.85, 28.14 290.84, 82.66 -70.09, -22.16 in-in in 8.292 Saltbr-in 2.737 HRD-in -76.48, -43.01 68.69, 3.02 in-in-out SNCiio in-out ActLoopNT-in 2.756 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 146.69 APE8-dihe-in -80.82, 73.73 APE8-rot-na 32.68 APE67-dihe-in -76.94, 0.52 -62.2, -25.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.081 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.8 0.193 0.213 A 309 263 21 0 0 4 [[545, 807], [849, 1125]] 2.0 6wtq Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 8G6ZA O60674 843 1131 1132.0 YSI:1201 Type1 Inactive DFGin 6.507 13.481 ABAminus -112.8, -5.23 -143.49, 146.77 -138.83, 38.03 298.53, 91.36 -63.83, -28.22 in-in in 8.18 Saltbr-in 2.549 HRD-in -65.64, -52.64 73.67, 5.8 in-in-in SNCiii in-in ActLoopNT-in 2.945 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.74, 129.64 APE9-dihe-in -136.21, 150.63 APE8-dihe-in -82.42, 71.95 APE8-rot-na 35.87 APE67-dihe-in -78.82, 3.44 -55.51, -28.44 APE12-dist-na 9.983 APE11-dist-na 10.956 APE10-dist-na 12.332 APE9-dist-in 7.453 M1073S,F1076T PTR1007 PTR1007 XRAY 2.45 0.228 0.281 A 318 281 8 0 0 2 [[545, 807], [849, 1125]] 2.0 8g6z Homo sapiens TYR_JAK2-2_HUMAN TYR 7.8e-87 296.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 8G6ZB O60674 843 1131 1132.0 YSI:1201 Type1 Inactive DFGin 6.478 13.519 ABAminus -114.28, -24.13 -123.15, 146.92 -135.04, 38.65 297.12, 87.98 -64.32, -25.66 in-in in 8.328 Saltbr-in 2.534 HRD-in -64.88, -55.1 79.03, -3.13 in-in-in SNCiii in-in ActLoopNT-in 2.948 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.77, 129.6 APE9-dihe-in -136.97, 149.24 APE8-dihe-in -83.09, 73.37 APE8-rot-na 34.87 APE67-dihe-in -79.65, 4.6 -55.74, -28.56 APE12-dist-na 10.387 APE11-dist-na 10.793 APE10-dist-na 11.978 APE9-dist-in 7.415 M1073S,F1076T PTR1007 PTR1007 XRAY 2.45 0.228 0.281 B 318 280 9 0 0 2 [[545, 807], [849, 1125]] 2.0 8g6z Homo sapiens TYR_JAK2-2_HUMAN TYR 7.8e-87 296.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 8G8OA O60674 842 1130 1132.0 YT0:1201 Type1 Inactive DFGin 6.202 13.361 ABAminus -120.55, -4.2 -147.29, 140.78 -131.57, 35.21 298.42, 95.45 -70.36, -19.76 in-in in 8.192 Saltbr-in 2.533 HRD-in -67.5, -52.92 71.36, 0.27 in-in-in SNCiii in-in ActLoopNT-in 2.717 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -53.6, 147.72 APE9-dihe-in -134.85, 143.13 APE8-dihe-in -73.21, 78.3 APE8-rot-na 29.04 APE67-dihe-in -74.11, 1.81 -65.23, -33.21 APE12-dist-na 13.898 APE11-dist-na 10.893 APE10-dist-na 12.109 APE9-dist-in 7.437 M1073S,F1076T PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.2 0.189 0.231 A 318 282 7 0 0 0 [[545, 807], [849, 1125]] 2.0 8g8o Homo sapiens TYR_JAK2-2_HUMAN TYR 7.8e-87 296.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 8G8OB O60674 843 1130 1132.0 YT0:1201 Type1 Inactive DFGin 6.195 13.456 ABAminus -116.17, -2.6 -150.03, 138.73 -130.97, 33.74 298.07, 97.39 -67.58, -22.65 in-in in 8.303 Saltbr-in 2.5 HRD-in -66.68, -51.5 71.43, 0.69 in-in-none SNCiin in-none ActLoopNT-in 2.734 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 153.39 APE9-dihe-in -126.18, 143.79 APE8-dihe-in -69.22, 78.32 APE8-rot-na 30.12 APE67-dihe-in -74.43, 0.93 -67.38, -32.46 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.83 APE9-dist-in 7.655 M1073S,F1076T PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.2 0.189 0.231 B 318 279 9 0 0 3 [[545, 807], [849, 1125]] 2.0 8g8o Homo sapiens TYR_JAK2-2_HUMAN TYR 7.8e-87 296.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 8G8XA O60674 842 1130 1132.0 YT8:1201 Type1 Inactive DFGin 6.287 13.621 ABAminus -128.64, 13.57 -157.75, 139.94 -132.4, 23.74 294.22, 91.25 -59.33, -23.18 in-in in 8.275 Saltbr-in 2.663 HRD-in -73.44, -46.22 72.51, -9.33 in-in-in SNCiii in-in ActLoopNT-in 2.802 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -57.22, 138.12 APE9-dihe-in -120.1, 150.86 APE8-dihe-in -76.91, 73.06 APE8-rot-na 33.65 APE67-dihe-in -77.05, 1.87 -66.0, -28.97 APE12-dist-na 13.891 APE11-dist-na 11.252 APE10-dist-na 12.307 APE9-dist-in 7.589 M1073S,F1076T PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.97 0.197 0.236 A 318 279 10 0 0 0 [[545, 807], [849, 1125]] 2.0 8g8x Homo sapiens TYR_JAK2-2_HUMAN TYR 7.8e-87 296.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 8G8XB O60674 842 1130 1132.0 YT8:1201 Type1 Inactive DFGin 6.305 13.625 ABAminus -131.5, 13.18 -154.49, 140.48 -130.41, 26.19 295.07, 93.87 -67.86, -20.04 in-in in 8.318 Saltbr-in 2.66 HRD-in -75.4, -49.99 77.29, -20.66 in-in-none SNCiin in-none ActLoopNT-in 2.78 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 148.7 APE9-dihe-in -121.49, 150.25 APE8-dihe-in -78.15, 75.05 APE8-rot-na 34.71 APE67-dihe-in -78.89, 2.08 -66.22, -28.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.395 APE9-dist-in 7.624 M1073S,F1076T PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.97 0.197 0.236 B 318 283 6 0 0 3 [[545, 807], [849, 1125]] 2.0 8g8x Homo sapiens TYR_JAK2-2_HUMAN TYR 7.8e-87 296.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 3IO7A O60674 842 1130 1132.0 1P5:1 Type1 Inactive DFGin 6.301 13.815 ABAminus -112.16, -1.32 -145.89, 149.76 -140.76, 26.89 292.99, 90.84 -59.52, -22.75 in-in in 8.824 Saltbr-in 2.811 HRD-in -55.86, -45.98 63.25, 8.93 in-in-in SNCiii in-in ActLoopNT-in 2.869 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.54, 138.09 APE9-dihe-in -133.41, 110.4 APE8-dihe-in -73.98, 70.25 APE8-rot-na 29.13 APE67-dihe-in -67.35, -10.36 -61.07, -31.41 APE12-dist-na 10.917 APE11-dist-na 9.773 APE10-dist-na 9.373 APE9-dist-in 7.014 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.6 0.206 0.294 A 313 284 5 0 0 0 [[545, 807], [849, 1125]] 2.0 3io7 Homo sapiens TYR_JAK2-2_HUMAN TYR 3.1e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 3IOKA O60674 842 1130 1132.0 1P6:1201 Type1 Inactive DFGin 6.096 13.541 ABAminus -121.32, -1.67 -146.25, 142.19 -132.46, 26.61 298.26, 86.73 -60.37, -26.17 in-in in 8.866 Saltbr-in 2.758 HRD-in -69.45, -45.65 73.01, -14.13 in-in-in SNCiii in-in ActLoopNT-in 2.893 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -46.78, 118.71 APE9-dihe-in -139.1, 105.64 APE8-dihe-in -78.75, 70.53 APE8-rot-na 31.27 APE67-dihe-in -75.46, -3.39 -51.2, -30.09 APE12-dist-na 10.916 APE11-dist-na 9.84 APE10-dist-na 7.394 APE9-dist-in 7.058 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.1 0.228 0.27 A 313 287 2 0 0 0 [[545, 807], [849, 1125]] 2.0 3iok Homo sapiens TYR_JAK2-2_HUMAN TYR 3.1e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 8BX9A O60674 840 1132 1132.0 S59:61201 Type1 Inactive DFGin 6.282 13.313 ABAminus -115.66, -15.46 -143.67, 143.69 -132.35, 26.34 296.6, 90.45 -62.57, -27.31 in-in in 8.693 Saltbr-in 2.708 HRD-in -72.71, -45.4 77.34, -11.34 in-in-in SNCiii in-in ActLoopNT-in 2.812 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.37, 138.38 APE9-dihe-in -118.57, 132.52 APE8-dihe-in -81.71, 72.52 APE8-rot-na 30.52 APE67-dihe-in -77.4, -1.6 -57.61, -31.37 APE12-dist-na 10.348 APE11-dist-na 9.382 APE10-dist-na 10.331 APE9-dist-in 7.339 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.4 0.193 0.223 A 316 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8bx9 Homo sapiens TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 8BX9B O60674 840 1132 1132.0 S59:61201 Type1 Inactive DFGin 6.291 13.332 ABAminus -114.72, -14.51 -143.68, 140.34 -129.13, 28.22 298.96, 84.54 -63.48, -25.1 in-in in 8.666 Saltbr-in 2.644 HRD-in -70.33, -47.05 74.41, -10.04 in-in-in SNCiii in-in ActLoopNT-in 2.793 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.07, 136.0 APE9-dihe-in -119.91, 128.99 APE8-dihe-in -80.21, 75.11 APE8-rot-na 32.85 APE67-dihe-in -76.92, -1.3 -60.27, -31.85 APE12-dist-na 10.468 APE11-dist-na 9.724 APE10-dist-na 10.147 APE9-dist-in 7.285 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.4 0.193 0.223 B 316 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8bx9 Homo sapiens TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 8BXCA O60674 840 1132 1132.0 S4R:1201 Type1 Inactive DFGin 6.317 13.273 ABAminus -114.09, -8.87 -149.97, 142.12 -133.77, 26.82 296.68, 81.56 -66.21, -23.2 in-in in 8.414 Saltbr-in 2.829 HRD-in -70.66, -50.65 75.15, -2.01 in-in-in SNCiii in-in ActLoopNT-in 2.751 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -59.68, 118.56 APE9-dihe-in -120.33, 123.76 APE8-dihe-in -80.89, 77.22 APE8-rot-na 32.94 APE67-dihe-in -79.78, -1.06 -63.1, -26.51 APE12-dist-na 11.275 APE11-dist-na 10.016 APE10-dist-na 9.625 APE9-dist-in 7.187 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.9 0.185 0.212 A 316 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8bxc Homo sapiens TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 8BXCB O60674 840 1131 1132.0 S4R:1202 Type1 Inactive DFGin 6.329 13.413 ABAminus -113.04, -4.23 -153.84, 142.12 -133.27, 27.51 295.22, 80.62 -63.7, -24.73 in-in in 8.348 Saltbr-in 2.687 HRD-in -71.82, -48.34 71.63, 1.45 in-in-out SNCiio in-out ActLoopNT-in 2.784 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 57.98, 67.78 APE9-dihe-in -109.48, 127.54 APE8-dihe-in -76.72, 73.7 APE8-rot-na 31.9 APE67-dihe-in -80.49, -2.19 -63.42, -23.88 APE12-dist-na 10.645 APE11-dist-na 10.848 APE10-dist-na 9.617 APE9-dist-in 7.152 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.9 0.185 0.212 B 316 292 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8bxc Homo sapiens TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 8BXHA O60674 840 1132 1132.0 C87:61201 Type1 Inactive DFGin 6.183 13.48 ABAminus -116.43, -2.68 -151.15, 148.41 -139.57, 22.33 295.88, 95.21 -64.33, -22.57 in-in in 8.486 Saltbr-in 2.667 HRD-in -70.75, -47.1 73.22, -3.09 in-in-in SNCiii in-in ActLoopNT-in 2.814 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.87, 128.71 APE9-dihe-in -114.3, 130.49 APE8-dihe-in -78.73, 74.05 APE8-rot-na 31.88 APE67-dihe-in -78.01, -2.31 -59.56, -30.79 APE12-dist-na 10.824 APE11-dist-na 9.715 APE10-dist-na 10.372 APE9-dist-in 7.251 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.3 0.146 0.168 A 316 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8bxh Homo sapiens TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 8BPVA O60674 840 1132 1132.0 6T3:61201 Type1 Inactive DFGin 6.233 13.683 ABAminus -116.56, -36.11 -124.2, 138.28 -129.59, 22.59 292.57, 84.89 -62.94, -24.65 in-in in 8.519 Saltbr-in 2.663 HRD-in -72.07, -43.66 72.8, -7.66 in-in-in SNCiii in-in ActLoopNT-in 2.816 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.52, 127.49 APE9-dihe-in -110.12, 130.52 APE8-dihe-in -77.35, 72.52 APE8-rot-na 32.09 APE67-dihe-in -77.69, -0.43 -59.29, -31.15 APE12-dist-na 10.581 APE11-dist-na 9.423 APE10-dist-na 10.23 APE9-dist-in 7.335 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.7 0.173 0.198 A 317 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8bpv Homo sapiens TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 8BPWA O60674 840 1132 1132.0 2V9:61201 Type1 Inactive DFGin 6.215 13.646 ABAminus -115.19, -48.31 -103.06, 116.82 -112.02, 18.76 287.81, 84.2 -63.54, -25.29 in-in in 8.484 Saltbr-in 2.996 HRD-in -64.59, -48.42 72.07, 3.03 in-in-in SNCiii in-in ActLoopNT-in 2.78 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.29, 123.58 APE9-dihe-in -114.84, 131.32 APE8-dihe-in -78.29, 74.82 APE8-rot-na 31.98 APE67-dihe-in -81.09, 3.66 -62.61, -27.13 APE12-dist-na 11.055 APE11-dist-na 10.031 APE10-dist-na 10.285 APE9-dist-in 7.466 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.8 0.163 0.197 A 317 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8bpw Homo sapiens TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 8BPWB O60674 840 1132 1132.0 2V9:61201 Type1 Inactive DFGin 6.297 13.887 ABAminus -111.51, -47.7 -108.79, 109.16 -104.77, 22.85 290.19, 83.67 -62.05, -23.01 in-in in 8.735 Saltbr-in 3.025 HRD-in -67.26, -44.61 65.05, 5.26 in-in-in SNCiii in-in ActLoopNT-in 2.761 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.76, 134.33 APE9-dihe-in -123.62, 132.56 APE8-dihe-in -77.84, 75.4 APE8-rot-na 31.91 APE67-dihe-in -80.86, -1.2 -58.88, -29.17 APE12-dist-na 11.075 APE11-dist-na 9.621 APE10-dist-na 10.468 APE9-dist-in 7.297 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.8 0.163 0.197 B 317 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8bpw Homo sapiens TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4ZIMA O60674 842 1131 1132.0 4OK:61201 Type1 Inactive DFGin 6.256 13.524 ABAminus -102.09, -6.97 -147.71, 148.02 -137.31, 29.43 300.7, 95.51 -55.05, -34.04 in-in in 8.595 Saltbr-in 2.797 HRD-in -53.87, -50.26 65.52, 9.71 in-in-in SNCiii in-in ActLoopNT-in 2.732 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -90.04, 117.49 APE9-dihe-in -95.25, 146.52 APE8-dihe-in -75.87, 68.0 APE8-rot-na 26.85 APE67-dihe-in -81.7, -1.44 -56.38, -28.63 APE12-dist-na 13.079 APE11-dist-na 12.404 APE10-dist-na 12.923 APE9-dist-in 7.594 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.65 0.204 0.274 A 321 287 3 0 0 0 [[545, 807], [849, 1125]] 2.0 4zim Homo sapiens TYR_JAK2-2_HUMAN TYR 3.4e-87 298.0 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4ZIMB O60674 839 1132 1132.0 4OK:61201 Type1 Inactive DFGin 6.31 13.573 ABAminus -101.81, -6.62 -147.61, 146.1 -135.69, 28.39 301.03, 95.65 -55.21, -33.63 in-in in 8.573 Saltbr-in 2.811 HRD-in -54.97, -54.79 72.19, 10.05 in-in-in SNCiii in-in ActLoopNT-in 2.73 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.16, 96.7 APE9-dihe-in -86.92, 138.92 APE8-dihe-in -75.37, 68.14 APE8-rot-na 27.6 APE67-dihe-in -81.8, -0.82 -56.64, -28.71 APE12-dist-na 12.564 APE11-dist-na 10.097 APE10-dist-na 12.046 APE9-dist-in 7.577 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.65 0.204 0.274 B 321 294 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4zim Homo sapiens TYR_JAK2-2_HUMAN TYR 3.4e-87 298.0 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 5CF4A O60674 843 1131 1132.0 50Y:4000 Type1 Inactive DFGin 6.295 13.579 ABAminus -103.56, 3.37 -156.43, 145.58 -135.49, 36.18 298.36, 87.67 -61.24, -32.94 in-in in 8.471 Saltbr-in 2.725 HRD-in -60.77, -47.53 65.86, 5.68 in-in-in SNCiii in-in ActLoopNT-in 2.753 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.53, 110.94 APE9-dihe-in -84.82, 139.81 APE8-dihe-in -78.84, 67.91 APE8-rot-na 30.09 APE67-dihe-in -80.84, 0.88 -52.35, -28.91 APE12-dist-na 13.014 APE11-dist-na 12.171 APE10-dist-na 13.191 APE9-dist-in 7.812 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.38 0.252 0.253 A 321 285 4 0 0 0 [[545, 807], [849, 1125]] 2.0 5cf4 Homo sapiens TYR_JAK2-2_HUMAN TYR 3.4e-87 298.0 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 5CF4B O60674 839 1132 1132.0 50Y:4000 Type1 Inactive DFGin 6.357 13.609 ABAminus -103.87, 5.06 -157.73, 143.99 -135.02, 36.0 298.42, 86.53 -61.5, -31.7 in-in in 8.449 Saltbr-in 2.768 HRD-in -62.02, -51.24 72.04, 5.25 in-in-out SNCiio in-out ActLoopNT-in 2.756 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 49.02, 84.4 APE9-dihe-in -103.49, 134.66 APE8-dihe-in -78.95, 68.18 APE8-rot-na 29.68 APE67-dihe-in -80.17, 0.94 -52.54, -29.08 APE12-dist-na 12.873 APE11-dist-na 11.403 APE10-dist-na 11.854 APE9-dist-in 7.867 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.38 0.252 0.253 B 321 293 1 0 0 0 [[545, 807], [849, 1125]] 2.0 5cf4 Homo sapiens TYR_JAK2-2_HUMAN TYR 3.4e-87 298.0 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 5CF5A O60674 842 1132 1132.0 50W:64000 Type1 Inactive DFGin 6.318 13.581 ABAminus -106.13, 0.46 -155.61, 145.68 -133.99, 32.21 297.37, 84.13 -60.56, -30.29 in-in in 8.499 Saltbr-in 2.776 HRD-in -63.82, -46.49 65.44, 2.47 in-in-out SNCiio in-out ActLoopNT-in 2.754 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out 18.66, 109.36 APE9-dihe-in -98.47, 150.84 APE8-dihe-in -80.28, 69.58 APE8-rot-na 31.09 APE67-dihe-in -78.37, -4.04 -58.67, -29.57 APE12-dist-na 12.911 APE11-dist-na 12.769 APE10-dist-na 13.276 APE9-dist-out 8.022 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.45 0.187 0.199 A 321 288 3 0 0 0 [[545, 807], [849, 1125]] 2.0 5cf5 Homo sapiens TYR_JAK2-2_HUMAN TYR 3.4e-87 298.0 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 5CF5B O60674 839 1132 1132.0 50W:64000 Type1 Inactive DFGin 6.366 13.586 ABAminus -105.36, 0.35 -155.34, 144.46 -134.01, 32.12 297.68, 83.75 -61.64, -29.62 in-in in 8.455 Saltbr-in 2.813 HRD-in -64.6, -47.11 66.71, 2.52 in-in-in SNCiii in-in ActLoopNT-in 2.763 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.2, 111.77 APE9-dihe-in -119.03, 140.54 APE8-dihe-in -81.94, 67.92 APE8-rot-na 30.1 APE67-dihe-in -78.8, -4.12 -52.51, -28.89 APE12-dist-na 9.69 APE11-dist-na 10.862 APE10-dist-na 11.845 APE9-dist-in 7.875 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.45 0.187 0.199 B 321 294 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5cf5 Homo sapiens TYR_JAK2-2_HUMAN TYR 3.4e-87 298.0 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 5CF6A O60674 842 1131 1132.0 50O:64000 Type1 Inactive DFGin 6.294 13.492 ABAminus -104.13, 1.62 -156.18, 144.42 -132.41, 30.68 297.44, 85.19 -58.71, -30.05 in-in in 8.402 Saltbr-in 2.803 HRD-in -64.91, -47.46 68.86, -4.67 in-in-in SNCiii in-in ActLoopNT-in 2.777 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.12, 114.93 APE9-dihe-in -87.57, 141.3 APE8-dihe-in -74.44, 75.42 APE8-rot-na 29.19 APE67-dihe-in -80.74, -1.76 -62.41, -25.89 APE12-dist-na 12.787 APE11-dist-na 12.279 APE10-dist-na 13.222 APE9-dist-in 7.898 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.5 0.187 0.214 A 321 287 3 0 0 0 [[545, 807], [849, 1125]] 2.0 5cf6 Homo sapiens TYR_JAK2-2_HUMAN TYR 3.4e-87 298.0 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 5CF6B O60674 839 1132 1132.0 50O:64000 Type1 Inactive DFGin 6.328 13.502 ABAminus -102.75, 1.1 -157.33, 143.82 -132.8, 30.05 297.51, 85.67 -59.73, -28.47 in-in in 8.342 Saltbr-in 2.832 HRD-in -65.26, -47.89 69.87, -4.78 in-in-in SNCiii in-in ActLoopNT-in 2.779 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.07, 114.0 APE9-dihe-in -116.42, 144.16 APE8-dihe-in -79.24, 65.15 APE8-rot-na 28.53 APE67-dihe-in -81.85, -1.06 -52.72, -29.08 APE12-dist-na 12.249 APE11-dist-na 10.493 APE10-dist-na 11.521 APE9-dist-in 7.569 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.5 0.187 0.214 B 321 290 4 0 0 0 [[545, 807], [849, 1125]] 2.0 5cf6 Homo sapiens TYR_JAK2-2_HUMAN TYR 3.4e-87 298.0 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4E6DA O60674 840 1132 1132.0 0NU:1201 Type1 Inactive DFGin 6.096 13.312 ABAminus -122.24, 3.75 -153.98, 144.84 -134.34, 24.14 296.82, 81.89 -55.12, -26.57 in-in in 8.248 Saltbr-in 2.649 HRD-in -69.92, -47.82 71.55, -0.63 in-in-in SNCiii in-in ActLoopNT-in 2.685 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.79, 131.23 APE9-dihe-in -111.58, 150.84 APE8-dihe-in -76.94, 65.01 APE8-rot-na 34.92 APE67-dihe-in -79.16, -3.09 -56.44, -27.07 APE12-dist-na 12.506 APE11-dist-na 13.314 APE10-dist-na 12.774 APE9-dist-in 7.967 Q853R,Y931F,D939E PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.22 0.162 0.203 A 298 288 5 0 0 0 [[545, 807], [849, 1125]] 2.0 4e6d Homo sapiens TYR_JAK2-2_HUMAN TYR 4.9e-87 297.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4E6DB O60674 840 1132 1132.0 0NU:1201 Type1 Inactive DFGin 6.306 13.387 ABAminus -117.06, 8.14 -158.35, 146.27 -137.86, 24.42 294.7, 80.09 -57.56, -27.02 in-in in 8.175 Saltbr-in 2.721 HRD-in -78.46, -40.84 73.08, -9.79 in-in-in SNCiii in-in ActLoopNT-in 2.796 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -62.69, 149.18 APE9-dihe-in -123.01, 137.44 APE8-dihe-in -75.9, 62.49 APE8-rot-na 355.6 APE67-dihe-in -81.97, -0.11 -52.79, -31.49 APE12-dist-na 7.25 APE11-dist-na 9.882 APE10-dist-na 11.579 APE9-dist-in 7.652 Q853R,Y931F,D939E PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.22 0.162 0.203 B 298 288 5 0 0 0 [[545, 807], [849, 1125]] 2.0 4e6d Homo sapiens TYR_JAK2-2_HUMAN TYR 4.9e-87 297.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4E6QA O60674 835 1132 1132.0 0NV:1201 Type1 Inactive DFGin 6.269 13.45 ABAminus -126.67, 13.67 -142.89, 143.88 -137.27, 22.15 296.58, 95.03 -64.63, -19.34 in-in in 8.366 Saltbr-in 2.874 HRD-in -63.97, -49.26 71.25, 9.0 in-in-out SNCiio in-out ActLoopNT-in 2.733 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -67.76, 142.09 APE9-dihe-in -117.85, 160.32 APE8-dihe-in -76.9, 79.46 APE8-rot-na 30.98 APE67-dihe-in -84.05, -2.56 -64.72, -24.34 APE12-dist-na 13.753 APE11-dist-na 13.35 APE10-dist-na 14.079 APE9-dist-out 8.198 Q853R,Y931F,D939E PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.948 0.189 0.234 A 298 298 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4e6q Homo sapiens TYR_JAK2-2_HUMAN TYR 4.9e-87 297.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4E6QB O60674 835 1132 1132.0 0NV:1201 Type1 Inactive DFGin 6.309 13.393 ABAminus -126.92, 5.36 -155.12, 144.98 -131.94, 23.19 295.89, 95.38 -67.11, -25.79 in-in in 8.118 Saltbr-in 2.373 HRD-in -66.33, -47.39 73.85, -0.29 in-in-out SNCiio in-out ActLoopNT-in 2.983 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -76.02, 138.29 APE9-dihe-in -102.23, 152.61 APE8-dihe-in -79.57, 76.43 APE8-rot-na 29.69 APE67-dihe-in -80.89, 2.35 -56.64, -31.57 APE12-dist-na 13.86 APE11-dist-na 12.97 APE10-dist-na 13.982 APE9-dist-out 8.456 Q853R,Y931F,D939E PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.948 0.189 0.234 B 298 298 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4e6q Homo sapiens TYR_JAK2-2_HUMAN TYR 4.9e-87 297.5 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 2XA4A O60674 843 1130 1132.0 AZ5:2131 Type1 Inactive DFGin 6.321 13.847 ABAminus -121.7, -5.46 -148.03, 137.82 -132.4, 31.72 296.05, 86.79 -68.8, -26.4 in-in in 8.543 Saltbr-in 2.486 HRD-in -71.2, -45.88 73.36, -2.24 in-in-none SNCiin in-none ActLoopNT-in 2.754 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 126.78 APE9-dihe-in -107.35, 156.84 APE8-dihe-in -77.77, 72.68 APE8-rot-na 32.4 APE67-dihe-in -78.43, -2.14 -60.39, -28.3 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.548 APE9-dist-in 7.401 K943A,K945A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.04 0.2 0.245 A 298 278 10 0 0 4 [[545, 807], [849, 1125]] 2.0 2xa4 Homo sapiens TYR_JAK2-2_HUMAN TYR 1.1e-86 296.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 2XA4B O60674 843 1131 1132.0 AZ5:2132 Type1 Inactive DFGin 6.36 13.939 ABAminus -114.45, -6.24 -145.12, 137.4 -128.21, 30.09 293.01, 86.49 -67.85, -24.85 in-in in 8.604 Saltbr-in 2.567 HRD-in -74.84, -43.44 74.17, -13.1 in-in-in SNCiii in-in ActLoopNT-in 2.846 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.26, 151.87 APE9-dihe-in -119.66, 134.15 APE8-dihe-in -79.04, 70.15 APE8-rot-na 35.49 APE67-dihe-in -81.02, -6.09 -54.48, -27.27 APE12-dist-na 999.0 APE11-dist-na 10.196 APE10-dist-na 11.428 APE9-dist-in 7.642 K943A,K945A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.04 0.2 0.245 B 298 277 12 0 0 1 [[545, 807], [849, 1125]] 2.0 2xa4 Homo sapiens TYR_JAK2-2_HUMAN TYR 1.1e-86 296.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 3ZMMA O60674 844 1130 1132.0 F9J:2133 Type1 Inactive DFGin 6.565 13.901 ABAminus -124.92, 4.32 -148.66, 145.32 -139.04, 35.94 291.38, 91.22 -76.64, -20.0 in-in in 8.47 Saltbr-in 2.626 HRD-in -74.41, -53.48 82.29, -12.58 in-in-none SNCiin in-none ActLoopNT-in 2.69 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 144.54 APE9-dihe-in -152.47, 158.96 APE8-dihe-in -87.79, 67.39 APE8-rot-na 35.81 APE67-dihe-in -75.46, -0.84 -60.96, -24.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.382 APE9-dist-in 7.793 K943A,K945A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.51 0.195 0.246 A 298 275 12 0 0 4 [[545, 807], [849, 1125]] 2.0 3zmm Homo sapiens TYR_JAK2-2_HUMAN TYR 1.1e-86 296.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 3ZMMB O60674 843 1131 1132.0 F9J:2134 Type1 Inactive DFGin 6.572 14.222 ABAminus -118.91, 2.8 -144.65, 134.95 -129.24, 31.19 288.83, 86.73 -65.15, -32.55 in-in in 8.494 Saltbr-in 2.631 HRD-in -67.1, -39.55 67.31, -4.77 in-in-in SNCiii in-in ActLoopNT-in 2.809 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -137.08, 109.88 APE9-dihe-in -113.35, 152.82 APE8-dihe-in -78.67, 75.19 APE8-rot-na 30.04 APE67-dihe-in -84.91, -6.79 -57.53, -23.83 APE12-dist-na 11.336 APE11-dist-na 11.902 APE10-dist-na 12.137 APE9-dist-in 7.69 K943A,K945A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.51 0.195 0.246 B 298 276 13 0 0 0 [[545, 807], [849, 1125]] 2.0 3zmm Homo sapiens TYR_JAK2-2_HUMAN TYR 1.1e-86 296.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4C61A O60674 844 1130 1132.0 LMM:2133 Type1 Inactive DFGin 6.532 13.992 ABAminus -100.5, -7.49 -142.5, 135.85 -127.75, 28.69 291.26, 86.96 -61.78, -31.29 in-in in 8.46 Saltbr-in 2.748 HRD-in -61.21, -51.25 72.4, -7.24 in-in-none SNCiin in-none ActLoopNT-in 2.723 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 116.09 APE9-dihe-in -128.96, 149.61 APE8-dihe-in -80.23, 71.12 APE8-rot-na 29.74 APE67-dihe-in -78.54, -3.02 -52.78, -33.19 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.707 APE9-dist-in 7.497 K943A,K945A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.45 0.182 0.217 A 298 274 13 0 0 4 [[545, 807], [849, 1125]] 2.0 4c61 Homo sapiens TYR_JAK2-2_HUMAN TYR 1.1e-86 296.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4C61B O60674 843 1131 1132.0 LMM:3134 Type1 Inactive DFGin 6.587 13.964 ABAminus -99.29, -7.41 -144.35, 135.64 -128.8, 28.74 291.58, 87.68 -61.03, -31.63 in-in in 8.425 Saltbr-in 2.733 HRD-in -61.64, -51.8 71.18, -7.39 in-in-in SNCiii in-in ActLoopNT-in 2.717 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.27, 116.76 APE9-dihe-in -129.15, 144.96 APE8-dihe-in -79.41, 70.56 APE8-rot-na 30.9 APE67-dihe-in -79.29, -3.33 -51.49, -32.42 APE12-dist-na 10.495 APE11-dist-na 11.91 APE10-dist-na 11.206 APE9-dist-in 7.524 K943A,K945A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.45 0.182 0.217 B 298 276 13 0 0 0 [[545, 807], [849, 1125]] 2.0 4c61 Homo sapiens TYR_JAK2-2_HUMAN TYR 1.1e-86 296.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4C62A O60674 844 1130 1132.0 XWW:2133 Type1 Inactive DFGin 6.529 13.898 ABAminus -113.05, -0.79 -150.5, 138.69 -131.28, 30.16 295.66, 95.47 -70.5, -17.57 in-in in 8.529 Saltbr-in 2.745 HRD-in -77.66, -50.29 78.32, -7.51 in-in-none SNCiin in-none ActLoopNT-in 2.76 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 124.25 APE9-dihe-in -114.5, 154.43 APE8-dihe-in -78.75, 69.66 APE8-rot-na 32.02 APE67-dihe-in -77.58, -7.44 -57.08, -29.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.316 APE9-dist-in 7.438 K943A,K945A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.75 0.199 0.246 A 298 275 12 0 0 4 [[545, 807], [849, 1125]] 2.0 4c62 Homo sapiens TYR_JAK2-2_HUMAN TYR 1.1e-86 296.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4C62B O60674 843 1131 1132.0 XWW:2135 Type1 Inactive DFGin 6.485 13.894 ABAminus -114.61, 4.06 -154.86, 137.03 -130.79, 31.93 295.01, 94.29 -69.55, -19.77 in-in in 8.553 Saltbr-in 2.823 HRD-in -79.26, -45.4 75.54, -12.71 in-in-in SNCiii in-in ActLoopNT-in 2.771 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -104.27, 116.68 APE9-dihe-in -110.1, 148.45 APE8-dihe-in -73.84, 72.01 APE8-rot-na 31.1 APE67-dihe-in -81.36, -4.7 -56.44, -28.7 APE12-dist-na 12.231 APE11-dist-na 11.26 APE10-dist-na 12.209 APE9-dist-in 7.492 K943A,K945A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.75 0.199 0.246 B 298 273 16 0 0 0 [[545, 807], [849, 1125]] 2.0 4c62 Homo sapiens TYR_JAK2-2_HUMAN TYR 1.1e-86 296.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 5HEZC O60674 842 1132 1132.0 1M3:1201,1M3:1202 Type1,Allosteric Inactive DFGin 6.167 13.569 ABAminus -103.82, 3.86 -148.69, 138.92 -132.75, 28.94 299.92, 92.74 -60.0, -27.11 in-in in 8.287 Saltbr-in 2.747 HRD-in -60.66, -47.83 77.19, -22.6 in-in-out SNCiio in-out ActLoopNT-in 2.817 ActLoopCT-out TYR APEdihe_oioao APEdist_aaao APE10-dihe-out -104.85, 22.51 APE9-dihe-in -86.59, 123.97 APE8-dihe-out -80.09, -0.5 APE8-rot-na 27.2 APE67-dihe-out -118.37, -51.6 -67.71, 128.02 APE12-dist-na 10.904 APE11-dist-na 13.374 APE10-dist-na 11.281 APE9-dist-out 8.854 P1057A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.66 0.218 0.238 C 302 291 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5hez Homo sapiens TYR_JAK2-2_HUMAN TYR 3.7e-87 297.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 2W1IB O60674 843 1132 1132.0 No_ligand No_ligand Inactive DFGin 5.997 13.845 BLAminus -129.87, -167.39 53.3, 77.87 -90.81, 22.6 298.76, 93.77 -65.07, -29.79 in-out in 8.428 Saltbr-out 3.849 HRD-in -57.34, -41.14 62.34, 9.12 out-in-in SNCoii in-in ActLoopNT-in 2.721 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -53.98, 136.0 APE9-dihe-in -141.41, 130.69 APE8-dihe-in -74.31, 69.47 APE8-rot-na 31.54 APE67-dihe-in -71.28, -6.63 -56.8, -34.08 APE12-dist-na 10.481 APE11-dist-na 9.48 APE10-dist-na 10.251 APE9-dist-in 6.786 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.6 0.209 0.295 B 326 286 4 0 0 0 [[545, 807], [849, 1125]] 2.0 2w1i Homo sapiens TYR_JAK2-2_HUMAN TYR 3.6e-87 298.0 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6DRWA O60674 840 1131 1132.0 SKE:61201 Type1 Inactive DFGin 6.272 14.004 BLAminus -135.62, -164.15 53.36, 70.98 -94.26, 33.85 297.13, 87.99 -70.79, -31.52 in-out in 8.273 Saltbr-out 3.745 HRD-in -68.89, -41.09 70.39, -6.99 out-in-none SNCoin in-none ActLoopNT-in 2.729 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 112.68 APE8-dihe-in -73.32, 76.55 APE8-rot-na 28.19 APE67-dihe-in -76.44, -0.11 -65.53, -30.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.486 None PTR1007 PTR1007 XRAY 2.303 0.216 0.255 A 316 287 5 0 0 3 [[545, 807], [849, 1125]] 2.0 6drw Homo sapiens TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 6TPDA O60674 842 1130 1132.0 QZ8:1201 Type1 Inactive DFGin 6.63 14.76 BLAminus -124.83, -158.73 59.79, 63.27 -93.49, 16.99 294.26, 88.24 -63.81, -25.57 in-in in 8.328 Saltbr-in 3.335 HRD-in -71.82, -47.85 72.16, -6.01 in-in-out SNCiio in-out ActLoopNT-in 2.803 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 70.21, 68.81 APE9-dihe-in -104.96, 158.71 APE8-dihe-in -79.2, 75.08 APE8-rot-na 33.87 APE67-dihe-in -77.56, -1.44 -58.33, -26.98 APE12-dist-na 10.403 APE11-dist-na 12.515 APE10-dist-na 12.776 APE9-dist-in 7.862 None None None XRAY 1.99 0.226 0.278 A 289 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6tpd Homo sapiens TYR_JAK2-2_HUMAN TYR 1e-85 293.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 5TQ4A O60674 841 1132 1132.0 7GY:4000 Type1.5_Back Inactive DFGin 6.986 15.576 BLAminus -126.97, -150.42 5.26, 93.28 -93.68, 31.39 284.52, 81.78 -74.22, -14.45 in-in in 8.964 Saltbr-in 3.156 HRD-in -67.84, -48.95 79.15, -11.54 in-in-out SNCiio in-out ActLoopNT-in 2.969 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -95.18, 108.56 APE9-dihe-in -105.14, 150.08 APE8-dihe-in -86.77, 77.3 APE8-rot-na 31.15 APE67-dihe-in -77.77, -0.55 -58.88, -32.93 APE12-dist-na 11.62 APE11-dist-na 9.761 APE10-dist-na 11.634 APE9-dist-out 8.166 M1073S,F1076T PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.3 0.249 0.279 A 298 292 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5tq4 Homo sapiens TYR_JAK2-2_HUMAN TYR 6.1e-87 297.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 5TQ3A O60674 843 1132 1132.0 7GZ:4000 Type1.5_Back Inactive DFGin 6.737 14.799 None 172.87, 131.46 -138.34, 98.39 -97.83, 27.37 287.51, 86.01 -80.9, -8.4 in-in in 8.584 Saltbr-in 2.836 HRD-in -60.87, -46.98 70.99, 1.64 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.52, 122.1 APE9-dihe-in -107.12, 143.94 APE8-dihe-in -76.54, 73.52 APE8-rot-na 28.78 APE67-dihe-in -71.43, -5.04 -57.67, -36.56 APE12-dist-na 9.152 APE11-dist-na 10.628 APE10-dist-na 11.386 APE9-dist-in 7.326 M1073S,F1076T,I1126V PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.69 0.219 0.271 A 304 284 6 0 0 2 [[545, 807], [849, 1125]] 2.0 5tq3 Homo sapiens TYR_JAK2-2_HUMAN TYR 6.6e-87 297.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 5TQ3B O60674 843 1132 1132.0 7GZ:4001 Type1.5_Back Inactive DFGin 6.737 14.798 None 175.33, 157.26 -141.41, 99.71 -97.33, 27.05 288.19, 85.47 -80.15, -9.61 in-in in 8.574 Saltbr-in 2.88 HRD-in -62.69, -46.43 69.37, 2.93 in-in-in SNCiii in-in ActLoopNT-in 2.955 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.61, 127.26 APE9-dihe-in -88.47, 146.55 APE8-dihe-in -72.07, 80.22 APE8-rot-na 34.9 APE67-dihe-in -69.96, -5.59 -60.36, -37.68 APE12-dist-na 12.144 APE11-dist-na 10.877 APE10-dist-na 11.876 APE9-dist-in 7.199 M1073S,F1076T,I1126V PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.69 0.219 0.271 B 304 287 3 0 0 0 [[545, 807], [849, 1125]] 2.0 5tq3 Homo sapiens TYR_JAK2-2_HUMAN TYR 6.6e-87 297.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 7RN6A O60674 839 1130 1132.0 046:61201 Type2 Inactive DFGout 14.849 10.032 BBAminus -142.9, -161.3 -155.9, 101.54 -56.95, -47.21 271.11, 99.06 62.67, 34.57 in-in in 8.4 Saltbr-in 2.853 HRD-in -71.23, -54.0 79.2, -32.78 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nioai APEdist_aaao APE10-dihe-none 999.0, 23.78 APE9-dihe-in -68.64, 133.62 APE8-dihe-out -69.28, -14.0 APE8-rot-na 30.51 APE67-dihe-in -77.29, 3.35 -60.18, -24.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.997 APE9-dist-out 11.023 None PTR1007 PTR1007 XRAY 1.5 0.19 0.214 A 298 270 22 0 0 16 [[545, 807], [849, 1125]] 2.0 7rn6 Homo sapiens TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 3UGCA O60674 843 1129 1132.0 046:1201 Type2 Inactive DFGout 15.041 10.383 BBAminus -140.53, -160.06 -162.81, 97.88 -51.65, -50.95 277.97, 90.44 63.84, 37.94 in-in in 8.398 Saltbr-in 2.778 HRD-in -68.11, -58.01 83.55, -37.27 in-out-out SNCioo out-out ActLoopNT-out 14.979 ActLoopCT-out TYR APEdihe_oioai APEdist_aaao APE10-dihe-out -100.96, -0.55 APE9-dihe-in -75.25, 134.38 APE8-dihe-out -78.02, -9.14 APE8-rot-na 29.56 APE67-dihe-in -74.84, -0.63 -60.59, -24.73 APE12-dist-na 19.039 APE11-dist-na 16.385 APE10-dist-na 12.022 APE9-dist-out 11.188 Y1007F,Y1008F None None XRAY 1.34 0.177 0.189 A 295 274 13 0 0 13 [[545, 807], [849, 1125]] 2.0 3ugc Homo sapiens TYR_JAK2-2_HUMAN TYR 4.6e-86 294.3 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 7TEUA O60674 843 1131 1132.0 I6C:1201 Type2 Inactive DFGout 14.305 10.598 BBAminus -138.23, -157.36 -163.3, 103.15 -64.67, -46.44 280.47, 106.62 49.38, 50.86 in-in in 8.283 Saltbr-in 2.86 HRD-in -76.64, -47.89 74.84, -32.91 in-out-out SNCioo out-out ActLoopNT-out 16.198 ActLoopCT-out TYR APEdihe_oioai APEdist_aaao APE10-dihe-out -95.98, 15.17 APE9-dihe-in -100.26, 136.67 APE8-dihe-out -72.55, -11.79 APE8-rot-na 28.68 APE67-dihe-in -77.6, -0.85 -63.7, -21.24 APE12-dist-na 19.564 APE11-dist-na 16.952 APE10-dist-na 12.55 APE9-dist-out 11.163 Y1007F,Y1008F None None XRAY 1.45 0.194 0.207 A 317 276 13 0 0 13 [[545, 807], [849, 1125]] 2.0 7teu Homo sapiens TYR_JAK2-2_HUMAN TYR 6e-86 293.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 4D1SA O60674 842 1130 1132.0 BJG:1141 Type1 None DFGin 6.153 14.03 BLAminus -124.84, -163.04 46.78, 76.68 -90.28, 22.64 295.97, 91.18 -59.77, -25.09 in-in in 8.462 Saltbr-in 2.749 HRD-in -72.78, -44.48 72.51, -0.35 in-in-none SNCiin in-none ActLoopNT-in 2.776 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.85 APE8-dihe-in -79.29, 70.09 APE8-rot-na 33.83 APE67-dihe-in -78.27, -2.32 -57.11, -28.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.736 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.66 0.205 0.231 A 298 282 7 0 0 5 [[545, 807], [849, 1125]] 2.0 4d1s Homo sapiens TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 5USYA O60674 840 1130 1132.0 SKE:1201 Type1 None DFGin 6.298 14.188 BLAminus -130.23, -164.34 47.33, 79.32 -93.1, 20.71 291.84, 98.58 -62.97, -21.55 in-in in 8.613 Saltbr-in 2.803 HRD-in -71.47, -46.11 68.35, -0.6 in-in-none SNCiin in-none ActLoopNT-in 2.735 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.57 APE8-dihe-in -78.81, 76.11 APE8-rot-na 30.98 APE67-dihe-in -83.0, 0.49 -61.55, -24.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.265 None PTR1007 PTR1007 XRAY 2.0 0.178 0.216 A 316 288 3 0 0 3 [[545, 807], [849, 1125]] 2.0 5usy Homo sapiens TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_HUMAN 5USYB O60674 840 1130 1132.0 SKE:1201 Type1 None DFGin 6.309 14.253 BLAminus -121.96, -156.65 31.13, 87.35 -93.3, 22.45 292.93, 84.2 -66.48, -18.97 in-in in 8.443 Saltbr-in 2.973 HRD-in -70.92, -45.61 67.52, 2.98 in-in-none SNCiin in-none ActLoopNT-in 2.725 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.82 APE8-dihe-in -82.14, 78.44 APE8-rot-na 33.08 APE67-dihe-in -81.92, -0.91 -60.29, -26.19 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.406 None PTR1007 PTR1007 XRAY 2.0 0.178 0.216 B 316 288 3 0 0 3 [[545, 807], [849, 1125]] 2.0 5usy Homo sapiens TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_MOUSE 4GL9D Q62120 843 1130 1132.0 IZA:61201 Type1 Active DFGin 6.113 14.104 BLAminus -130.51, 174.55 54.31, 81.77 -91.69, 33.32 299.7, 91.33 -57.81, -43.55 in-in in 9.037 Saltbr-in 3.326 HRD-in -75.42, -43.64 65.18, -41.08 in-in-in SNCiii in-in ActLoopNT-in 3.109 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.34, 133.7 APE9-dihe-in -146.39, 149.67 APE8-dihe-in -76.13, 80.18 APE8-rot-na 27.12 APE67-dihe-in -82.31, -26.02 -65.86, -16.39 APE12-dist-na 11.461 APE11-dist-na 10.314 APE10-dist-na 10.79 APE9-dist-in 7.989 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 3.9 0.254 0.281 D 297 284 4 0 0 0 [[545, 807], [849, 1125]] 2.0 4gl9 Mus musculus TYR_JAK2-2_MOUSE TYR 7.3e-87 296.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_MOUSE 4GL9A Q62120 843 1130 1132.0 IZA:62001 Type1 Inactive DFGin 5.758 14.535 BLAminus -131.1, 175.47 54.64, 81.14 -92.19, 32.98 300.1, 95.95 -58.27, -44.01 in-in in 9.035 Saltbr-in 3.36 HRD-in -73.72, -44.47 64.56, -43.96 in-in-out SNCiio in-out ActLoopNT-in 3.107 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -55.67, 134.18 APE9-dihe-in -146.45, 151.12 APE8-dihe-in -74.76, 79.94 APE8-rot-na 27.08 APE67-dihe-in -82.75, -26.09 -66.14, -14.69 APE12-dist-na 11.898 APE11-dist-na 11.346 APE10-dist-na 12.126 APE9-dist-out 8.495 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 3.9 0.254 0.281 A 297 284 4 0 0 0 [[545, 807], [849, 1125]] 2.0 4gl9 Mus musculus TYR_JAK2-2_MOUSE TYR 7.3e-87 296.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_MOUSE 4GL9B Q62120 843 1130 1132.0 IZA:61201 Type1 Inactive DFGin 5.926 13.957 BLAminus -131.65, 175.34 54.28, 82.24 -93.18, 32.79 301.63, 90.67 -58.15, -43.04 in-in in 8.784 Saltbr-in 2.777 HRD-in -75.15, -44.99 64.86, -43.48 in-in-out SNCiio in-out ActLoopNT-in 3.173 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -55.23, 133.88 APE9-dihe-in -145.62, 151.28 APE8-dihe-in -74.33, 80.39 APE8-rot-na 26.93 APE67-dihe-in -82.22, -25.66 -66.02, -15.3 APE12-dist-na 10.854 APE11-dist-na 10.546 APE10-dist-na 11.576 APE9-dist-out 8.155 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 3.9 0.254 0.281 B 297 282 6 0 0 0 [[545, 807], [849, 1125]] 2.0 4gl9 Mus musculus TYR_JAK2-2_MOUSE TYR 7.3e-87 296.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_MOUSE 4GL9C Q62120 843 1130 1132.0 IZA:61201 Type1 Inactive DFGin 6.067 14.339 BLAminus -130.77, 175.48 54.57, 81.25 -92.89, 33.32 299.53, 89.15 -58.8, -44.7 in-in in 9.076 Saltbr-in 2.996 HRD-in -74.67, -44.19 64.59, -44.72 in-in-out SNCiio in-out ActLoopNT-in 2.94 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -53.52, 135.21 APE9-dihe-in -144.8, 151.59 APE8-dihe-in -74.44, 79.48 APE8-rot-na 27.41 APE67-dihe-in -84.46, -26.89 -66.72, -16.8 APE12-dist-na 11.515 APE11-dist-na 11.177 APE10-dist-na 11.856 APE9-dist-out 8.48 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 3.9 0.254 0.281 C 297 284 4 0 0 0 [[545, 807], [849, 1125]] 2.0 4gl9 Mus musculus TYR_JAK2-2_MOUSE TYR 7.3e-87 296.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2

TYR_JAK2-2 (Tyrosine-protein kinase JAK2)

Total number of chains: 4
Active chains: 1
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 4GL9D
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
JAK2_MOUSE 4GL9D Q62120 843 1130 1132.0 IZA:61201 Type1 Active DFGin 6.113 14.104 BLAminus -130.51, 174.55 54.31, 81.77 -91.69, 33.32 299.7, 91.33 -57.81, -43.55 in-in in 9.037 Saltbr-in 3.326 HRD-in -75.42, -43.64 65.18, -41.08 in-in-in SNCiii in-in ActLoopNT-in 3.109 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.34, 133.7 APE9-dihe-in -146.39, 149.67 APE8-dihe-in -76.13, 80.18 APE8-rot-na 27.12 APE67-dihe-in -82.31, -26.02 -65.86, -16.39 APE12-dist-na 11.461 APE11-dist-na 10.314 APE10-dist-na 10.79 APE9-dist-in 7.989 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 3.9 0.254 0.281 D 297 284 4 0 0 0 [[545, 807], [849, 1125]] 2.0 4gl9 Mus musculus TYR_JAK2-2_MOUSE TYR 7.3e-87 296.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_MOUSE 4GL9A Q62120 843 1130 1132.0 IZA:62001 Type1 Inactive DFGin 5.758 14.535 BLAminus -131.1, 175.47 54.64, 81.14 -92.19, 32.98 300.1, 95.95 -58.27, -44.01 in-in in 9.035 Saltbr-in 3.36 HRD-in -73.72, -44.47 64.56, -43.96 in-in-out SNCiio in-out ActLoopNT-in 3.107 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -55.67, 134.18 APE9-dihe-in -146.45, 151.12 APE8-dihe-in -74.76, 79.94 APE8-rot-na 27.08 APE67-dihe-in -82.75, -26.09 -66.14, -14.69 APE12-dist-na 11.898 APE11-dist-na 11.346 APE10-dist-na 12.126 APE9-dist-out 8.495 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 3.9 0.254 0.281 A 297 284 4 0 0 0 [[545, 807], [849, 1125]] 2.0 4gl9 Mus musculus TYR_JAK2-2_MOUSE TYR 7.3e-87 296.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_MOUSE 4GL9B Q62120 843 1130 1132.0 IZA:61201 Type1 Inactive DFGin 5.926 13.957 BLAminus -131.65, 175.34 54.28, 82.24 -93.18, 32.79 301.63, 90.67 -58.15, -43.04 in-in in 8.784 Saltbr-in 2.777 HRD-in -75.15, -44.99 64.86, -43.48 in-in-out SNCiio in-out ActLoopNT-in 3.173 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -55.23, 133.88 APE9-dihe-in -145.62, 151.28 APE8-dihe-in -74.33, 80.39 APE8-rot-na 26.93 APE67-dihe-in -82.22, -25.66 -66.02, -15.3 APE12-dist-na 10.854 APE11-dist-na 10.546 APE10-dist-na 11.576 APE9-dist-out 8.155 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 3.9 0.254 0.281 B 297 282 6 0 0 0 [[545, 807], [849, 1125]] 2.0 4gl9 Mus musculus TYR_JAK2-2_MOUSE TYR 7.3e-87 296.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
JAK2_MOUSE 4GL9C Q62120 843 1130 1132.0 IZA:61201 Type1 Inactive DFGin 6.067 14.339 BLAminus -130.77, 175.48 54.57, 81.25 -92.89, 33.32 299.53, 89.15 -58.8, -44.7 in-in in 9.076 Saltbr-in 2.996 HRD-in -74.67, -44.19 64.59, -44.72 in-in-out SNCiio in-out ActLoopNT-in 2.94 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -53.52, 135.21 APE9-dihe-in -144.8, 151.59 APE8-dihe-in -74.44, 79.48 APE8-rot-na 27.41 APE67-dihe-in -84.46, -26.89 -66.72, -16.8 APE12-dist-na 11.515 APE11-dist-na 11.177 APE10-dist-na 11.856 APE9-dist-out 8.48 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 3.9 0.254 0.281 C 297 284 4 0 0 0 [[545, 807], [849, 1125]] 2.0 4gl9 Mus musculus TYR_JAK2-2_MOUSE TYR 7.3e-87 296.9 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2