TYR_IGF1R (Insulin-like growth factor 1 receptor)

Total number of chains: 74
Active chains: 2
Uniprot: IGF1R_HUMAN
Kinase Domain Residues: 999 - 1268
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 30 40.5% 5FXSA
DFGin ABAminus 24 32.4% 2ZM3A
DFGout None 7 9.5% 3O23A
DFGin BLAminus 4 5.4% AF-P08069-K1A
DFGinter None 4 5.4% 1P4OA
DFGout BBAminus 3 4.1% 3LW0A
DFGin BLBminus 1 1.4% 3QQUA
None None 1 1.4% 2OJ9A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P08069-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 991 - 1276 0 None None Insulin-like growth factor 1 receptor
AF-P08069-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 991 - 1276 0 None None Insulin-like growth factor 1 receptor
1K3AA 2.1 Inactive DFGin‑ABAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai ACP ATPlike 988 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
2ZM3A 2.5 Inactive DFGin‑ABAminus in-out in-out TYR APEdihe_oiiai APEdist_aaai 575 Type1 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
2ZM3B 2.5 Inactive DFGin‑ABAminus in-out in-out TYR APEdihe_oiiai APEdist_aaai 575 Type1 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
2ZM3C 2.5 Inactive DFGin‑ABAminus in-out in-out TYR APEdihe_oiiai APEdist_aaai 575 Type1 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
2ZM3D 2.5 Inactive DFGin‑ABAminus in-out in-out TYR APEdihe_oiiai APEdist_aaai 575 Type1 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
3LVPA 3.0 Inactive DFGin‑ABAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai PDR Type1 989 - 1286 0 None None Insulin-like growth factor 1 receptor
3LVPB 3.0 Inactive DFGin‑ABAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai PDR Type1 986 - 1285 0 None None Insulin-like growth factor 1 receptor
3LVPC 3.0 Inactive DFGin‑ABAminus in-out in-out TYR APEdihe_oiiai APEdist_aaai PDR Type1 987 - 1286 0 None None Insulin-like growth factor 1 receptor
3F5PA 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
3F5PB 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
3F5PC 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
3F5PD 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
3F5PE 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
3F5PF 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
3F5PG 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
3F5PH 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
3F5PI 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
3F5PJ 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
3F5PK 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
3F5PL 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
3F5PM 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
3F5PR 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
3F5PS 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
3F5PT 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor
3QQUC 2.9 Inactive DFGin‑BLAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 01P Type1 989 - 1285 0 None None Insulin-like growth factor 1 receptor
3QQUA 2.9 Inactive DFGin‑BLBminus in-out out-in TYR APEdihe_iiiai APEdist_aaai 01P Type1 991 - 1285 0 None None Insulin-like growth factor 1 receptor
1JQHA 2.1 Inactive DFGin‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 984 - 1286 0 None E979G,Y980S Insulin-like growth factor 1 receptor
1JQHB 2.1 Inactive DFGin‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 984 - 1286 0 None E979G,Y980S Insulin-like growth factor 1 receptor
1JQHC 2.1 Inactive DFGin‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 984 - 1286 0 None E979G,Y980S Insulin-like growth factor 1 receptor
3QQUB 2.9 Inactive DFGin‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 01P Type1 988 - 1286 0 None None Insulin-like growth factor 1 receptor
3QQUD 2.9 Inactive DFGin‑None in-out out-out TYR APEdihe_oiiai APEdist_aaai 01P Type1 989 - 1285 0 None None Insulin-like growth factor 1 receptor
4D2RA 2.1 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai DYK Type1 985 - 1286 0 None None Insulin-like growth factor 1 receptor
3NW5A 2.14 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai LGX Type1 985 - 1286 0 None None Insulin-like growth factor 1 receptor
3NW6A 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai LGW Type1 986 - 1286 0 None None Insulin-like growth factor 1 receptor
3NW7A 2.11 Inactive DFGin‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai LGV Type1 987 - 1286 0 None None Insulin-like growth factor 1 receptor
5FXQA 2.3 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai GD5 Type1 980 - 1286 0 None None Insulin-like growth factor 1 receptor
5FXRA 2.4 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 8LN Type1 980 - 1283 0 None None Insulin-like growth factor 1 receptor
3I81A 2.08 Inactive DFGin‑None out-out out-none TYR APEdihe_niiai APEdist_aaai EBI Type1 985 - 1286 0 None None Insulin-like growth factor 1 receptor
5FXSA 1.9 Inactive DFGin‑None out-none out-in TYR APEdihe_iiiai APEdist_aaai OZN Type1 980 - 1286 0 None None Insulin-like growth factor 1 receptor
3D94A 2.3 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai D94 Type1.5_Front 986 - 1285 0 None None Insulin-like growth factor 1 receptor
8PYIAAA 3.06 Inactive DFGin‑None out-out out-none TYR APEdihe_niiai APEdist_aaai IER Type1.5_Front 986 - 1286 0 None None Insulin-like growth factor 1 receptor
8PYIBBB 3.06 Inactive DFGin‑None out-out out-none TYR APEdihe_niiai APEdist_aaai IER Type1.5_Front 986 - 1285 0 None None Insulin-like growth factor 1 receptor
8PYICCC 3.06 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor
8PYIDDD 3.06 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor
8PYIEEE 3.06 Inactive DFGin‑None out-out out-none TYR APEdihe_niiai APEdist_aaai IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor
8PYIFFF 3.06 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor
8PYIGGG 3.06 Inactive DFGin‑None out-out out-none TYR APEdihe_niiai APEdist_aaai IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor
8PYIHHH 3.06 Inactive DFGin‑None out-out out-none TYR APEdihe_niiai APEdist_aaai IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor
5HZNA 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
5HZNB 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
5HZNC 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
5HZND 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
5HZNE 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
5HZNF 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
5HZNG 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
5HZNH 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1285 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
1M7NA 2.7 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 982 - 1286 0 None None Insulin-like growth factor 1 receptor
1M7NB 2.7 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 982 - 1286 0 None None Insulin-like growth factor 1 receptor
1P4OA 1.5 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 978 - 1285 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
1P4OB 1.5 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 977 - 1290 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
3LW0A 1.79 Inactive DFGout‑BBAminus in-out out-in TYR APEdihe_iiiai APEdist_aaai CCX, CCX Type3, Allosteric 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
3LW0B 1.79 Inactive DFGout‑BBAminus in-out out-in TYR APEdihe_iiiai APEdist_aaai CCX, CCX Type3, Allosteric 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
3LW0C 1.79 Inactive DFGout‑BBAminus in-out out-in TYR APEdihe_iiiai APEdist_aaai CCX, CCX Type3, Allosteric 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
3O23A 2.1 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai MQY Type2 991 - 1283 0 None Y987F Insulin-like growth factor 1 receptor
8PYJAAA 2.702 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai IEA Type2 986 - 1270 0 None None Insulin-like growth factor 1 receptor
8PYKAAA 2.23 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IC2 Type2 986 - 1270 0 None None Insulin-like growth factor 1 receptor
8PYLAAA 2.93 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IE0 Type2 986 - 1270 0 None None Insulin-like growth factor 1 receptor
8PYMAAA 2.652 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IED Type2 984 - 1270 0 None None Insulin-like growth factor 1 receptor
8PYNAAA 1.71 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai ICV Type2 986 - 1270 0 None None Insulin-like growth factor 1 receptor
3LW0D 1.79 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai CCX, CCX Type3, Allosteric 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
2OJ9A 2.0 Inactive None‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai BMI Type1 984 - 1286 0 None None Insulin-like growth factor 1 receptor
3LVPD 3.0 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai PDR Type1 986 - 1285 0 None None Insulin-like growth factor 1 receptor

TYR_IGF1R (Insulin-like growth factor 1 receptor)

Total number of chains: 74
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 30 40.5% 5FXSA
DFGin ABAminus 24 32.4% 2ZM3A
DFGout None 7 9.5% 3O23A
DFGin BLAminus 4 5.4% AF-P08069-K1A
DFGinter None 4 5.4% 1P4OA
DFGout BBAminus 3 4.1% 3LW0A
DFGin BLBminus 1 1.4% 3QQUA
None None 1 1.4% 2OJ9A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
IGF1R_HUMAN AF-P08069-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 991 - 1276 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN AF-P08069-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 991 - 1276 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 1K3AA 2.1 Inactive DFGin‑ABAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai ACP ATPlike 988 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 2ZM3A 2.5 Inactive DFGin‑ABAminus in-out in-out TYR APEdihe_oiiai APEdist_aaai 575 Type1 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 2ZM3B 2.5 Inactive DFGin‑ABAminus in-out in-out TYR APEdihe_oiiai APEdist_aaai 575 Type1 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 2ZM3C 2.5 Inactive DFGin‑ABAminus in-out in-out TYR APEdihe_oiiai APEdist_aaai 575 Type1 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 2ZM3D 2.5 Inactive DFGin‑ABAminus in-out in-out TYR APEdihe_oiiai APEdist_aaai 575 Type1 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3LVPA 3.0 Inactive DFGin‑ABAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai PDR Type1 989 - 1286 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3LVPB 3.0 Inactive DFGin‑ABAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai PDR Type1 986 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3LVPC 3.0 Inactive DFGin‑ABAminus in-out in-out TYR APEdihe_oiiai APEdist_aaai PDR Type1 987 - 1286 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3F5PA 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3F5PB 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3F5PC 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3F5PD 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3F5PE 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3F5PF 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3F5PG 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3F5PH 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3F5PI 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3F5PJ 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3F5PK 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3F5PL 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3F5PM 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3F5PR 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1285 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3F5PS 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3F5PT 2.9 Inactive DFGin‑ABAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai 741 Type1.5_Front 981 - 1286 0 PTR1161,PTR1165,PTR1166 None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3QQUC 2.9 Inactive DFGin‑BLAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 01P Type1 989 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3QQUA 2.9 Inactive DFGin‑BLBminus in-out out-in TYR APEdihe_iiiai APEdist_aaai 01P Type1 991 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 1JQHA 2.1 Inactive DFGin‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 984 - 1286 0 None E979G,Y980S Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 1JQHB 2.1 Inactive DFGin‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 984 - 1286 0 None E979G,Y980S Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 1JQHC 2.1 Inactive DFGin‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 984 - 1286 0 None E979G,Y980S Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3QQUB 2.9 Inactive DFGin‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 01P Type1 988 - 1286 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3QQUD 2.9 Inactive DFGin‑None in-out out-out TYR APEdihe_oiiai APEdist_aaai 01P Type1 989 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 4D2RA 2.1 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai DYK Type1 985 - 1286 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3NW5A 2.14 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai LGX Type1 985 - 1286 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3NW6A 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai LGW Type1 986 - 1286 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3NW7A 2.11 Inactive DFGin‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai LGV Type1 987 - 1286 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 5FXQA 2.3 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai GD5 Type1 980 - 1286 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 5FXRA 2.4 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 8LN Type1 980 - 1283 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3I81A 2.08 Inactive DFGin‑None out-out out-none TYR APEdihe_niiai APEdist_aaai EBI Type1 985 - 1286 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 5FXSA 1.9 Inactive DFGin‑None out-none out-in TYR APEdihe_iiiai APEdist_aaai OZN Type1 980 - 1286 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3D94A 2.3 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai D94 Type1.5_Front 986 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 8PYIAAA 3.06 Inactive DFGin‑None out-out out-none TYR APEdihe_niiai APEdist_aaai IER Type1.5_Front 986 - 1286 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 8PYIBBB 3.06 Inactive DFGin‑None out-out out-none TYR APEdihe_niiai APEdist_aaai IER Type1.5_Front 986 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 8PYICCC 3.06 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 8PYIDDD 3.06 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 8PYIEEE 3.06 Inactive DFGin‑None out-out out-none TYR APEdihe_niiai APEdist_aaai IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 8PYIFFF 3.06 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 8PYIGGG 3.06 Inactive DFGin‑None out-out out-none TYR APEdihe_niiai APEdist_aaai IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 8PYIHHH 3.06 Inactive DFGin‑None out-out out-none TYR APEdihe_niiai APEdist_aaai IER Type1.5_Front 987 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 5HZNA 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 5HZNB 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 5HZNC 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 5HZND 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 5HZNE 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 5HZNF 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 5HZNG 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 5HZNH 2.2 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 66A Type1.5_Front 983 - 1285 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 1M7NA 2.7 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 982 - 1286 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 1M7NB 2.7 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 982 - 1286 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 1P4OA 1.5 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 978 - 1285 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 1P4OB 1.5 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 977 - 1290 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3LW0A 1.79 Inactive DFGout‑BBAminus in-out out-in TYR APEdihe_iiiai APEdist_aaai CCX, CCX Type3, Allosteric 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3LW0B 1.79 Inactive DFGout‑BBAminus in-out out-in TYR APEdihe_iiiai APEdist_aaai CCX, CCX Type3, Allosteric 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3LW0C 1.79 Inactive DFGout‑BBAminus in-out out-in TYR APEdihe_iiiai APEdist_aaai CCX, CCX Type3, Allosteric 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3O23A 2.1 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai MQY Type2 991 - 1283 0 None Y987F Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 8PYJAAA 2.702 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai IEA Type2 986 - 1270 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 8PYKAAA 2.23 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IC2 Type2 986 - 1270 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 8PYLAAA 2.93 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IE0 Type2 986 - 1270 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 8PYMAAA 2.652 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IED Type2 984 - 1270 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 8PYNAAA 1.71 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai ICV Type2 986 - 1270 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3LW0D 1.79 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai CCX, CCX Type3, Allosteric 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 2OJ9A 2.0 Inactive None‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai BMI Type1 984 - 1286 0 None None Insulin-like growth factor 1 receptor Homo sapiens
IGF1R_HUMAN 3LVPD 3.0 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai PDR Type1 986 - 1285 0 None None Insulin-like growth factor 1 receptor Homo sapiens

TYR_IGF1R (Insulin-like growth factor 1 receptor)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism