TYR_IGF1R (Insulin-like growth factor 1 receptor)

Total number of chains: 74
Active chains: 2
Family: TYR
Uniprot: IGF1R_HUMAN
Kinase Domain Residues: 999 - 1268
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 30 40.5% 5FXSA
DFGin ABAminus 24 32.4% 2ZM3A
DFGout None 7 9.5% 3O23A
DFGin BLAminus 4 5.4% AF-P08069-K1A
DFGinter None 4 5.4% 1P4OA
DFGout BBAminus 3 4.1% 3LW0A
DFGin BLBminus 1 1.4% 3QQUA
None None 1 1.4% 2OJ9A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P08069-K1A 991 1276 1367.0 No_ligand No_ligand Active DFGin 6.643 13.608 BLAminus -135.67, -174.5 50.5, 80.19 -91.57, 14.84 300.61, 100.02 -58.88, -30.47 in-in in 8.177 Saltbr-in 2.67 HRD-in -70.7, -43.4 67.54, -16.33 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -57.17, 140.22 APE9-dihe-in -136.38, 138.83 APE8-dihe-in -78.03, 65.53 APE8-rot-na 35.47 APE67-dihe-in -78.02, -11.21 -44.96, -38.15 APE12-dist-na 15.113 APE11-dist-na 10.906 APE10-dist-na 10.15 APE9-dist-in 6.924 None None None AF2 -1.0 1.0 1.0 A 286 286 0 0 0 0 [[999, 1268]] 1.0 AF-P08069-K1 TYR_IGF1R_HUMAN TYR 1.5e-95 325.4 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
AF-P08069-K3A 991 1276 1367.0 No_ligand No_ligand Active DFGin 6.117 13.053 BLAminus -137.79, -171.74 47.09, 82.9 -94.36, 9.98 307.09, 101.02 -65.96, -22.69 in-in in 8.088 Saltbr-in 2.671 HRD-in -75.6, -44.24 66.53, -10.48 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -53.45, 145.29 APE9-dihe-in -144.44, 141.35 APE8-dihe-in -79.58, 60.38 APE8-rot-na 36.37 APE67-dihe-in -70.79, -12.12 -43.91, -40.05 APE12-dist-na 15.115 APE11-dist-na 11.247 APE10-dist-na 9.947 APE9-dist-in 6.744 None None None AF2 -1.0 1.0 1.0 A 286 286 0 0 0 0 [[999, 1268]] 1.0 AF-P08069-K3 TYR_IGF1R_HUMAN TYR 1.5e-95 325.4 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
1K3AA 988 1286 1367.0 ACP:60300 ATPlike Inactive DFGin 6.326 14.213 ABAminus -128.41, -4.91 -126.86, 131.72 -125.9, 30.62 307.04, 99.18 -55.79, -30.44 in-out in 9.005 Saltbr-out 4.763 HRD-in -68.21, -48.33 72.95, -10.46 out-in-in SNCoii in-in ActLoopNT-in 2.922 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -92.81, 106.37 APE9-dihe-in -118.2, 152.14 APE8-dihe-in -73.75, 68.45 APE8-rot-na 35.41 APE67-dihe-in -73.37, -1.85 -44.97, -44.15 APE12-dist-na 15.179 APE11-dist-na 11.105 APE10-dist-na 10.844 APE9-dist-in 7.129 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.1 0.212 0.251 A 299 291 8 0 0 0 [[999, 1268]] 1.0 1k3a TYR_IGF1R_HUMAN TYR 3.1e-95 324.3 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
2ZM3A 981 1285 1367.0 575:60001 Type1 Inactive DFGin 6.789 15.505 ABAminus -126.6, 3.02 -143.72, 130.04 -129.16, 19.26 296.34, 90.11 -55.9, -25.14 in-out in 9.527 Saltbr-out 4.852 HRD-in -72.76, -50.33 77.45, -5.62 out-in-out SNCoio in-out ActLoopNT-in 3.048 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -118.76, 9.6 APE9-dihe-in -63.6, 138.6 APE8-dihe-in -67.76, 134.68 APE8-rot-na 23.16 APE67-dihe-in -69.69, -0.78 -61.9, -34.84 APE12-dist-na 13.645 APE11-dist-na 9.848 APE10-dist-na 9.225 APE9-dist-in 5.645 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.5 0.204 0.257 A 308 302 3 0 0 0 [[999, 1268]] 1.0 2zm3 TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
2ZM3B 981 1285 1367.0 575:60001 Type1 Inactive DFGin 6.898 15.542 ABAminus -122.17, -30.49 -117.45, 117.57 -113.54, 25.96 293.65, 87.06 -63.47, -21.66 in-out in 9.271 Saltbr-out 4.722 HRD-in -70.83, -52.07 75.8, -5.9 out-in-out SNCoio in-out ActLoopNT-in 2.903 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -116.67, 22.47 APE9-dihe-in -72.91, 143.81 APE8-dihe-in -66.5, 133.93 APE8-rot-na 346.04 APE67-dihe-in -76.24, -7.5 -59.54, -34.53 APE12-dist-na 13.473 APE11-dist-na 9.742 APE10-dist-na 9.363 APE9-dist-in 5.867 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.5 0.204 0.257 B 308 298 7 0 0 0 [[999, 1268]] 1.0 2zm3 TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
2ZM3C 981 1285 1367.0 575:60001 Type1 Inactive DFGin 6.947 15.802 ABAminus -152.06, 34.97 -157.73, 111.59 -117.56, 21.8 294.76, 97.45 -67.22, -1.53 in-out in 9.294 Saltbr-out 4.566 HRD-in -77.37, -44.24 69.01, -4.52 out-in-out SNCoio in-out ActLoopNT-in 2.914 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -140.21, 38.41 APE9-dihe-in -71.06, 141.9 APE8-dihe-in -59.24, 134.31 APE8-rot-na 17.13 APE67-dihe-in -70.15, -0.4 -63.02, -34.83 APE12-dist-na 13.912 APE11-dist-na 9.841 APE10-dist-na 10.352 APE9-dist-in 5.839 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.5 0.204 0.257 C 308 298 7 0 0 0 [[999, 1268]] 1.0 2zm3 TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
2ZM3D 981 1285 1367.0 575:60001 Type1 Inactive DFGin 6.824 15.051 ABAminus -111.39, -39.63 -105.46, 131.68 -127.13, 27.77 299.55, 96.91 -65.49, -19.62 in-out in 9.687 Saltbr-out 5.274 HRD-in -74.05, -49.11 76.32, -10.43 out-in-out SNCoio in-out ActLoopNT-in 2.901 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -119.17, 22.3 APE9-dihe-in -75.96, 143.16 APE8-dihe-in -66.16, 129.67 APE8-rot-na 349.87 APE67-dihe-in -74.71, -7.32 -58.83, -32.73 APE12-dist-na 13.653 APE11-dist-na 9.739 APE10-dist-na 9.3 APE9-dist-in 5.836 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.5 0.204 0.257 D 308 295 10 0 0 0 [[999, 1268]] 1.0 2zm3 TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3LVPA 989 1286 1367.0 PDR:1 Type1 Inactive DFGin 6.057 14.189 ABAminus -121.12, 43.14 -157.44, 127.28 -132.71, 38.65 304.97, 81.73 -58.62, -41.18 in-out in 9.113 Saltbr-out 6.234 HRD-in -83.6, -34.91 64.8, -16.89 out-in-in SNCoii in-in ActLoopNT-in 3.21 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.15, 163.21 APE9-dihe-in -98.5, 148.37 APE8-dihe-in -75.76, 55.82 APE8-rot-na 35.7 APE67-dihe-in -60.82, -13.12 -37.4, -57.84 APE12-dist-na 11.81 APE11-dist-na 10.859 APE10-dist-na 12.555 APE9-dist-in 7.769 None None None XRAY 3.0 0.226 0.279 A 336 289 9 0 0 7 [[999, 1268]] 1.0 3lvp TYR_IGF1R_HUMAN TYR 2.6e-95 324.6 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3LVPB 986 1285 1367.0 PDR:2 Type1 Inactive DFGin 5.929 13.658 ABAminus -100.72, -41.98 -105.19, 149.94 -137.93, 21.74 308.71, 87.7 -51.11, -10.36 in-out in 9.376 Saltbr-out 4.699 HRD-in -75.05, -36.77 62.12, -0.15 out-in-in SNCoii in-in ActLoopNT-in 2.801 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -133.19, 147.36 APE9-dihe-in -73.98, 133.27 APE8-dihe-in -70.94, 67.87 APE8-rot-na 28.67 APE67-dihe-in -66.44, 0.67 -51.66, -49.49 APE12-dist-na 12.766 APE11-dist-na 10.848 APE10-dist-na 12.443 APE9-dist-in 7.627 None None None XRAY 3.0 0.226 0.279 B 336 295 5 0 0 0 [[999, 1268]] 1.0 3lvp TYR_IGF1R_HUMAN TYR 2.6e-95 324.6 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3LVPC 987 1286 1367.0 PDR:3 Type1 Inactive DFGin 6.602 14.705 ABAminus -128.34, 8.64 -136.7, 135.21 -140.34, 37.76 307.43, 72.91 -60.45, -40.08 in-out in 9.777 Saltbr-out 5.735 HRD-in -80.86, -39.6 60.48, 1.48 out-in-out SNCoio in-out ActLoopNT-in 3.067 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 53.07, 146.43 APE9-dihe-in -156.81, 103.94 APE8-dihe-in -81.83, 74.27 APE8-rot-na 32.03 APE67-dihe-in -72.67, -15.88 -39.8, -39.1 APE12-dist-na 7.873 APE11-dist-na 8.677 APE10-dist-na 7.38 APE9-dist-in 7.06 None None None XRAY 3.0 0.226 0.279 C 336 293 7 0 0 2 [[999, 1268]] 1.0 3lvp TYR_IGF1R_HUMAN TYR 2.6e-95 324.6 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3F5PA 981 1286 1367.0 741:60001 Type1.5_Front Inactive DFGin 6.61 16.748 ABAminus -138.06, -25.59 -129.58, 107.73 -116.06, 43.16 310.54, 93.03 -78.83, -11.08 out-out out 11.275 Saltbr-out 6.906 HRD-in -67.38, -43.83 73.05, -28.09 out-in-out SNCoio in-out ActLoopNT-in 2.971 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.2, 9.43 APE9-dihe-in -62.84, 138.01 APE8-dihe-in -63.08, 132.26 APE8-rot-na 338.19 APE67-dihe-in -72.6, -14.18 -69.93, -24.15 APE12-dist-na 13.896 APE11-dist-na 10.264 APE10-dist-na 9.82 APE9-dist-in 6.264 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 A 308 301 5 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3F5PB 981 1286 1367.0 741:60002 Type1.5_Front Inactive DFGin 6.74 16.774 ABAminus -147.75, -6.76 -126.37, 106.72 -113.94, 18.15 303.38, 100.96 -63.88, -6.59 out-out out 11.005 Saltbr-out 7.016 HRD-in -75.04, -39.09 66.41, -28.14 out-in-out SNCoio in-out ActLoopNT-in 2.98 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.44, 30.24 APE9-dihe-in -71.55, 137.53 APE8-dihe-in -59.54, 131.44 APE8-rot-na 338.8 APE67-dihe-in -62.32, -22.71 -80.06, -23.54 APE12-dist-na 13.869 APE11-dist-na 10.125 APE10-dist-na 10.151 APE9-dist-in 6.368 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 B 308 300 6 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3F5PC 981 1286 1367.0 741:60003 Type1.5_Front Inactive DFGin 6.476 16.508 ABAminus -131.28, -29.71 -123.17, 122.2 -124.32, 31.59 310.58, 97.96 -71.28, -4.47 out-out out 11.326 Saltbr-out 7.151 HRD-in -67.89, -44.01 69.59, -29.8 out-in-out SNCoio in-out ActLoopNT-in 2.929 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.67, 21.52 APE9-dihe-in -66.68, 135.08 APE8-dihe-in -55.37, 125.9 APE8-rot-na 335.16 APE67-dihe-in -63.64, -20.63 -71.03, -23.62 APE12-dist-na 13.947 APE11-dist-na 10.314 APE10-dist-na 10.017 APE9-dist-in 6.347 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 C 308 303 3 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3F5PD 981 1286 1367.0 741:60004 Type1.5_Front Inactive DFGin 6.691 16.948 ABAminus -123.55, -41.41 -120.41, 118.96 -120.72, 27.37 304.28, 99.29 -67.93, -13.37 out-out out 11.466 Saltbr-out 7.444 HRD-in -72.44, -43.38 70.69, -28.87 out-in-out SNCoio in-out ActLoopNT-in 2.922 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -114.64, 11.87 APE9-dihe-in -60.75, 136.9 APE8-dihe-in -61.78, 130.42 APE8-rot-na 20.36 APE67-dihe-in -67.44, -13.84 -72.23, -24.66 APE12-dist-na 13.872 APE11-dist-na 10.33 APE10-dist-na 10.049 APE9-dist-in 6.368 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 D 308 299 7 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3F5PE 981 1285 1367.0 741:60005 Type1.5_Front Inactive DFGin 6.694 16.82 ABAminus -135.52, -29.09 -118.77, 122.15 -123.6, 9.7 296.44, 108.3 -57.57, -18.08 out-out out 11.069 Saltbr-out 7.271 HRD-in -68.6, -42.13 69.21, -24.51 out-in-out SNCoio in-out ActLoopNT-in 2.855 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -119.4, 7.14 APE9-dihe-in -54.67, 137.93 APE8-dihe-in -65.35, 131.07 APE8-rot-na 341.16 APE67-dihe-in -64.5, -10.68 -68.92, -32.58 APE12-dist-na 14.021 APE11-dist-na 10.452 APE10-dist-na 10.148 APE9-dist-in 6.28 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 E 308 301 4 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3F5PF 981 1285 1367.0 741:60006 Type1.5_Front Inactive DFGin 6.483 16.672 ABAminus -133.64, -29.08 -124.95, 116.76 -119.73, 22.12 307.37, 101.54 -62.11, -21.12 out-out out 11.456 Saltbr-out 7.439 HRD-in -66.51, -41.75 69.88, -16.79 out-in-out SNCoio in-out ActLoopNT-in 2.973 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.91, 14.58 APE9-dihe-in -64.37, 136.64 APE8-dihe-in -51.49, 126.07 APE8-rot-na 332.53 APE67-dihe-in -71.57, -11.29 -75.66, -21.34 APE12-dist-na 14.067 APE11-dist-na 10.393 APE10-dist-na 10.014 APE9-dist-in 6.14 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 F 308 301 4 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3F5PG 981 1285 1367.0 741:60007 Type1.5_Front Inactive DFGin 6.83 16.816 ABAminus -142.79, -22.58 -124.37, 117.71 -119.99, 31.05 299.76, 104.87 -73.83, -11.77 out-out out 11.313 Saltbr-out 7.0 HRD-in -78.88, -44.79 72.24, -24.62 out-in-out SNCoio in-out ActLoopNT-in 2.969 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -107.94, 24.79 APE9-dihe-in -73.02, 139.57 APE8-dihe-in -63.97, 132.91 APE8-rot-na 337.39 APE67-dihe-in -71.97, -5.77 -75.29, -20.42 APE12-dist-na 14.012 APE11-dist-na 10.239 APE10-dist-na 9.892 APE9-dist-in 6.221 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 G 308 301 4 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3F5PH 981 1286 1367.0 741:60008 Type1.5_Front Inactive DFGin 6.629 16.429 ABAminus -135.18, -37.61 -123.09, 112.94 -114.78, 16.78 310.03, 93.21 -57.54, -9.93 out-out out 11.26 Saltbr-out 7.542 HRD-in -79.51, -41.44 75.33, -29.75 out-in-out SNCoio in-out ActLoopNT-in 2.981 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.47, 10.93 APE9-dihe-in -59.95, 134.42 APE8-dihe-in -57.02, 119.96 APE8-rot-na 332.96 APE67-dihe-in -72.4, -8.79 -61.06, -25.16 APE12-dist-na 14.198 APE11-dist-na 10.466 APE10-dist-na 10.185 APE9-dist-in 6.401 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 H 308 301 5 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3F5PI 981 1285 1367.0 741:60009 Type1.5_Front Inactive DFGin 6.637 16.461 ABAminus -144.33, -12.52 -125.22, 113.79 -116.99, 15.78 300.54, 108.07 -62.21, -14.24 out-out out 10.889 Saltbr-out 6.889 HRD-in -60.61, -42.68 67.93, -23.46 out-in-out SNCoio in-out ActLoopNT-in 2.917 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.73, 15.28 APE9-dihe-in -67.33, 139.53 APE8-dihe-in -63.65, 128.86 APE8-rot-na 345.01 APE67-dihe-in -68.57, -17.49 -69.06, -21.27 APE12-dist-na 13.914 APE11-dist-na 10.23 APE10-dist-na 9.797 APE9-dist-in 6.228 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 I 308 296 9 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3F5PJ 981 1285 1367.0 741:60010 Type1.5_Front Inactive DFGin 6.647 16.713 ABAminus -137.35, -22.07 -131.76, 119.09 -115.56, 22.57 300.22, 101.26 -61.94, -18.78 out-out out 10.94 Saltbr-out 6.672 HRD-in -74.88, -41.95 72.95, -30.32 out-in-out SNCoio in-out ActLoopNT-in 2.964 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -114.55, 26.2 APE9-dihe-in -76.04, 131.14 APE8-dihe-in -47.14, 118.18 APE8-rot-na 11.41 APE67-dihe-in -74.24, -9.54 -60.76, -20.49 APE12-dist-na 14.276 APE11-dist-na 10.237 APE10-dist-na 10.205 APE9-dist-in 6.46 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 J 308 295 10 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3F5PK 981 1285 1367.0 741:60011 Type1.5_Front Inactive DFGin 6.407 16.547 ABAminus -137.37, -28.84 -124.99, 120.18 -119.7, 16.02 301.42, 102.62 -59.26, -20.51 out-out out 11.163 Saltbr-out 6.697 HRD-in -69.13, -50.03 76.13, -25.52 out-in-out SNCoio in-out ActLoopNT-in 2.956 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -116.66, 8.96 APE9-dihe-in -58.52, 142.15 APE8-dihe-in -59.15, 129.43 APE8-rot-na 338.61 APE67-dihe-in -60.69, -25.24 -69.7, -27.83 APE12-dist-na 14.114 APE11-dist-na 10.152 APE10-dist-na 9.947 APE9-dist-in 6.405 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 K 308 295 10 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3F5PL 981 1285 1367.0 741:60013 Type1.5_Front Inactive DFGin 6.56 16.394 ABAminus -130.09, -30.53 -132.5, 115.28 -114.91, 24.81 310.05, 96.63 -62.07, -19.46 out-out out 11.029 Saltbr-out 6.97 HRD-in -66.51, -50.25 76.73, -28.84 out-in-out SNCoio in-out ActLoopNT-in 2.868 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.68, 19.75 APE9-dihe-in -67.29, 128.45 APE8-dihe-in -49.93, 126.32 APE8-rot-na 13.1 APE67-dihe-in -68.28, -21.28 -70.5, -21.67 APE12-dist-na 14.19 APE11-dist-na 10.315 APE10-dist-na 10.171 APE9-dist-in 6.356 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 L 308 295 10 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3F5PM 981 1285 1367.0 741:60012 Type1.5_Front Inactive DFGin 6.771 16.613 ABAminus -128.57, -42.47 -122.66, 116.51 -120.09, 38.47 314.34, 94.44 -73.17, -23.07 out-out out 11.214 Saltbr-out 7.332 HRD-in -78.25, -49.69 75.71, -26.22 out-in-out SNCoio in-out ActLoopNT-in 2.877 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.51, 9.39 APE9-dihe-in -60.52, 138.49 APE8-dihe-in -61.63, 125.4 APE8-rot-na 341.15 APE67-dihe-in -68.1, -5.47 -67.37, -25.72 APE12-dist-na 13.872 APE11-dist-na 10.161 APE10-dist-na 9.914 APE9-dist-in 6.394 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 M 308 297 8 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3F5PR 981 1285 1367.0 741:60014 Type1.5_Front Inactive DFGin 6.538 16.629 ABAminus -139.04, -20.87 -125.55, 103.39 -109.5, 25.04 311.13, 96.42 -58.59, -20.19 out-out out 11.106 Saltbr-out 7.253 HRD-in -61.08, -46.93 71.37, -30.05 out-in-out SNCoio in-out ActLoopNT-in 2.994 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -121.06, 13.96 APE9-dihe-in -63.18, 134.5 APE8-dihe-in -57.6, 125.54 APE8-rot-na 338.75 APE67-dihe-in -68.47, -18.65 -66.66, -22.95 APE12-dist-na 14.134 APE11-dist-na 10.186 APE10-dist-na 10.002 APE9-dist-in 6.439 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 R 308 296 9 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3F5PS 981 1286 1367.0 741:60015 Type1.5_Front Inactive DFGin 6.621 16.362 ABAminus -137.74, -25.34 -122.78, 115.95 -115.05, 8.88 304.38, 111.51 -47.71, -27.84 out-out out 11.103 Saltbr-out 6.886 HRD-in -69.09, -43.99 64.64, -15.6 out-in-out SNCoio in-out ActLoopNT-in 2.902 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -120.58, 17.02 APE9-dihe-in -62.27, 136.85 APE8-dihe-in -61.63, 122.69 APE8-rot-na 21.86 APE67-dihe-in -66.47, -21.61 -67.46, -19.45 APE12-dist-na 13.986 APE11-dist-na 10.237 APE10-dist-na 10.157 APE9-dist-in 6.245 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 S 308 297 9 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3F5PT 981 1286 1367.0 741:60016 Type1.5_Front Inactive DFGin 6.52 16.375 ABAminus -141.26, -19.49 -137.77, 101.2 -103.13, 11.95 304.34, 96.76 -50.98, -21.44 out-out out 10.787 Saltbr-out 6.707 HRD-in -77.18, -39.29 69.12, -25.78 out-in-out SNCoio in-out ActLoopNT-in 2.859 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -114.42, 13.71 APE9-dihe-in -68.71, 130.72 APE8-dihe-in -54.94, 124.12 APE8-rot-na 340.88 APE67-dihe-in -66.19, -17.17 -61.43, -26.74 APE12-dist-na 13.846 APE11-dist-na 10.239 APE10-dist-na 9.88 APE9-dist-in 6.273 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 T 308 297 9 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3QQUC 989 1285 1367.0 01P:60001 Type1 Inactive DFGin 8.318 16.87 BLAminus -97.01, 150.34 14.49, 98.68 -65.56, 26.06 281.91, 75.71 -140.07, 16.5 in-in in 9.191 Saltbr-in 3.594 HRD-out -77.97, 136.61 -108.26, 0.31 in-out-in SNCioi out-in ActLoopNT-out 16.858 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.41, 127.29 APE9-dihe-in -133.08, 155.06 APE8-dihe-in -87.24, 64.19 APE8-rot-na 38.0 APE67-dihe-in -67.35, -9.92 -53.34, -43.26 APE12-dist-na 22.831 APE11-dist-na 18.041 APE10-dist-na 14.399 APE9-dist-in 7.438 None None None XRAY 2.9 0.273 0.302 C 301 293 4 0 0 0 [[999, 1268]] 1.0 3qqu TYR_IGF1R_HUMAN TYR 1.8e-95 325.1 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3QQUA 991 1285 1367.0 01P:60001 Type1 Inactive DFGin 7.018 15.778 BLBminus -115.26, 159.62 28.18, 96.19 -42.42, 112.88 288.43, 150.16 68.34, -45.79 in-out in 9.091 Saltbr-out 5.093 HRD-out -66.07, 145.48 -122.95, 8.59 out-out-in SNCooi out-in ActLoopNT-out 16.955 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.25, 118.57 APE9-dihe-in -132.55, 144.54 APE8-dihe-in -85.92, 76.47 APE8-rot-na 33.89 APE67-dihe-in -71.18, -0.86 -64.59, -36.6 APE12-dist-na 20.861 APE11-dist-na 16.489 APE10-dist-na 12.487 APE9-dist-in 7.354 None None None XRAY 2.9 0.273 0.302 A 301 285 10 0 0 0 [[999, 1268]] 1.0 3qqu TYR_IGF1R_HUMAN TYR 1.8e-95 325.1 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
1JQHA 984 1286 1367.0 ANP:301 ATPlike Inactive DFGin 5.69 16.569 None -66.7, 163.88 -59.45, 151.32 -140.18, 178.07 43.94, 89.38 -106.76, 173.06 in-out in 9.977 Saltbr-out 6.056 HRD-in -50.88, -56.96 74.77, -3.78 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -84.24, 106.81 APE9-dihe-in -58.88, 134.76 APE8-dihe-in -78.96, 121.64 APE8-rot-na 37.96 APE67-dihe-in -60.45, -7.73 -52.46, -43.95 APE12-dist-na 7.157 APE11-dist-na 11.3 APE10-dist-na 15.597 APE9-dist-in 5.8 E979G,Y980S None None XRAY 2.1 0.195 0.219 A 308 291 12 0 0 7 [[999, 1268]] 1.0 1jqh TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
1JQHB 984 1286 1367.0 ANP:302 ATPlike Inactive DFGin 5.687 16.554 None -65.78, 164.4 -59.98, 151.89 -140.81, 178.2 43.68, 89.42 -109.69, -174.77 in-out in 9.988 Saltbr-out 6.019 HRD-in -51.69, -56.66 74.32, -2.97 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.6, 107.67 APE9-dihe-in -58.75, 135.36 APE8-dihe-in -79.54, 122.52 APE8-rot-na 37.69 APE67-dihe-in -59.25, -7.46 -52.18, -45.28 APE12-dist-na 6.817 APE11-dist-na 10.932 APE10-dist-na 15.216 APE9-dist-in 5.768 E979G,Y980S None None XRAY 2.1 0.195 0.219 B 308 287 16 0 0 7 [[999, 1268]] 1.0 1jqh TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
1JQHC 984 1286 1367.0 ANP:303 ATPlike Inactive DFGin 5.698 16.558 None -65.47, 162.73 -58.75, 151.62 -140.8, 179.03 43.87, 88.98 -110.24, -177.72 in-out in 9.999 Saltbr-out 6.035 HRD-in -53.2, -57.0 74.59, -2.63 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.9, 107.89 APE9-dihe-in -58.88, 134.76 APE8-dihe-in -79.04, 122.75 APE8-rot-na 38.27 APE67-dihe-in -60.34, -8.42 -53.61, -43.61 APE12-dist-na 6.926 APE11-dist-na 10.986 APE10-dist-na 15.245 APE9-dist-in 5.774 E979G,Y980S None None XRAY 2.1 0.195 0.219 C 308 291 12 0 0 7 [[999, 1268]] 1.0 1jqh TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3QQUB 988 1286 1367.0 01P:60001 Type1 Inactive DFGin 7.313 15.849 None -33.42, 160.47 -37.99, 116.49 -33.99, 105.39 285.12, 147.4 61.19, -16.27 in-out in 9.14 Saltbr-out 5.132 HRD-out -74.87, 134.07 -112.64, 23.07 out-out-in SNCooi out-in ActLoopNT-out 16.45 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.73, 125.53 APE9-dihe-in -129.43, 153.07 APE8-dihe-in -94.91, 67.38 APE8-rot-na 36.24 APE67-dihe-in -82.46, 4.52 -51.63, -28.48 APE12-dist-na 20.873 APE11-dist-na 16.306 APE10-dist-na 12.631 APE9-dist-in 7.052 None None None XRAY 2.9 0.273 0.302 B 301 288 11 0 0 0 [[999, 1268]] 1.0 3qqu TYR_IGF1R_HUMAN TYR 1.8e-95 325.1 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3QQUD 989 1285 1367.0 01P:60001 Type1 Inactive DFGin 7.865 16.342 None -72.27, 173.4 -41.63, 112.37 -69.49, 2.91 294.86, 82.49 -113.94, 14.31 in-out in 9.33 Saltbr-out 4.332 HRD-out -89.46, 130.4 -100.59, 1.17 out-out-out SNCooo out-out ActLoopNT-out 17.365 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 71.55, 69.22 APE9-dihe-in -124.37, 159.91 APE8-dihe-in -89.12, 68.21 APE8-rot-na 38.62 APE67-dihe-in -73.08, -17.7 -59.12, -27.53 APE12-dist-na 21.94 APE11-dist-na 19.125 APE10-dist-na 15.188 APE9-dist-in 7.458 None None None XRAY 2.9 0.273 0.302 D 301 292 5 0 0 0 [[999, 1268]] 1.0 3qqu TYR_IGF1R_HUMAN TYR 1.8e-95 325.1 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
4D2RA 985 1286 1367.0 DYK:2288 Type1 Inactive DFGin 6.17 16.203 None -69.68, 163.13 -53.49, 135.63 -66.9, 144.51 304.26, 163.38 61.31, 29.83 out-out out 10.267 Saltbr-out 6.647 HRD-in -70.04, -49.33 73.87, -13.98 out-out-in SNCooi out-in ActLoopNT-out 17.489 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.92, 112.08 APE9-dihe-in -125.82, 147.19 APE8-dihe-in -85.98, 69.81 APE8-rot-na 32.75 APE67-dihe-in -73.08, -8.74 -50.8, -35.19 APE12-dist-na 21.901 APE11-dist-na 17.034 APE10-dist-na 13.417 APE9-dist-in 7.156 None None None XRAY 2.1 0.181 0.221 A 302 300 2 0 0 2 [[999, 1268]] 1.0 4d2r TYR_IGF1R_HUMAN TYR 1.8e-95 325.1 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3NW5A 985 1286 1367.0 LGX:60001 Type1 Inactive DFGin 6.696 16.886 None -72.74, 167.89 -46.3, 134.17 -70.68, 160.99 291.97, 0.43 38.79, 22.82 out-out out 10.246 Saltbr-out 5.611 HRD-in -64.28, -52.64 77.7, -10.43 out-out-in SNCooi out-in ActLoopNT-out 16.559 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.81, 115.11 APE9-dihe-in -124.48, 143.18 APE8-dihe-in -78.32, 63.38 APE8-rot-na 28.02 APE67-dihe-in -71.11, -14.08 -47.07, -38.36 APE12-dist-na 20.295 APE11-dist-na 16.099 APE10-dist-na 12.81 APE9-dist-in 7.362 None None None XRAY 2.14 0.196 0.254 A 307 302 0 0 0 0 [[999, 1268]] 1.0 3nw5 TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3NW6A 986 1286 1367.0 LGW:60001 Type1 Inactive DFGin 6.379 16.329 None -74.88, 163.27 -46.43, 132.32 -66.66, 145.01 298.3, 172.57 60.37, 24.67 out-out out 10.116 Saltbr-out 5.223 HRD-in -71.12, -48.14 76.3, -15.79 out-out-in SNCooi out-in ActLoopNT-out 18.224 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.0, 97.67 APE9-dihe-in -118.49, 154.77 APE8-dihe-in -81.27, 69.63 APE8-rot-na 32.94 APE67-dihe-in -72.42, -10.33 -48.22, -40.81 APE12-dist-na 17.163 APE11-dist-na 16.709 APE10-dist-na 13.655 APE9-dist-in 7.171 None None None XRAY 2.2 0.184 0.253 A 307 301 0 0 0 0 [[999, 1268]] 1.0 3nw6 TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3NW7A 987 1286 1367.0 LGV:60001 Type1 Inactive DFGin 5.914 15.618 None -79.79, -167.52 -73.83, 143.18 -76.01, 139.22 303.93, 155.83 55.33, 50.19 in-out in 9.95 Saltbr-out 6.831 HRD-in -73.07, -47.61 73.35, -7.71 out-out-in SNCooi out-in ActLoopNT-out 15.576 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.1, 112.82 APE9-dihe-in -110.42, 135.27 APE8-dihe-in -85.88, 69.94 APE8-rot-na 27.32 APE67-dihe-in -72.04, -10.86 -50.71, -38.46 APE12-dist-na 999.0 APE11-dist-na 15.926 APE10-dist-na 11.794 APE9-dist-in 7.466 None None None XRAY 2.11 0.168 0.226 A 307 297 3 0 0 3 [[999, 1268]] 1.0 3nw7 TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
5FXQA 980 1286 1367.0 GD5:62287 Type1 Inactive DFGin 6.15 16.395 None -75.24, 161.17 -49.54, 127.03 -61.92, 123.0 295.29, 167.93 87.57, 25.79 out-out out 10.492 Saltbr-out 7.924 HRD-in -76.32, -54.31 77.35, -9.89 out-out-in SNCooi out-in ActLoopNT-out 15.064 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.4, 114.95 APE9-dihe-in -123.96, 146.04 APE8-dihe-in -82.98, 67.94 APE8-rot-na 28.97 APE67-dihe-in -76.69, -10.66 -53.34, -32.39 APE12-dist-na 999.0 APE11-dist-na 16.72 APE10-dist-na 13.032 APE9-dist-in 7.148 None None None XRAY 2.3 999.0 0.275 A 308 301 6 0 0 3 [[999, 1268]] 1.0 5fxq TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
5FXRA 980 1283 1367.0 8LN:62284 Type1 Inactive DFGin 6.364 16.559 None -71.13, 158.45 -48.25, 129.23 -64.15, 116.2 296.93, 166.85 93.0, 19.74 out-out out 10.539 Saltbr-out 7.176 HRD-in -75.83, -55.57 82.75, -12.94 out-out-in SNCooi out-in ActLoopNT-out 15.258 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.77, 112.68 APE9-dihe-in -129.53, 148.37 APE8-dihe-in -86.54, 69.56 APE8-rot-na 33.95 APE67-dihe-in -74.34, -9.8 -55.93, -31.36 APE12-dist-na 999.0 APE11-dist-na 17.455 APE10-dist-na 13.75 APE9-dist-in 7.242 None None None XRAY 2.4 0.23 0.294 A 308 299 4 0 0 3 [[999, 1268]] 1.0 5fxr TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3I81A 985 1286 1367.0 EBI:60201 Type1 Inactive DFGin 6.688 15.783 None -69.56, 174.65 -71.05, 142.28 -76.41, 136.92 311.88, 126.84 70.68, 14.21 out-out out 10.216 Saltbr-out 5.618 HRD-in -62.27, -48.86 72.23, -18.63 out-out-none SNCoon out-none ActLoopNT-out 16.975 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -54.18 APE9-dihe-in -126.35, 139.61 APE8-dihe-in -88.27, 72.05 APE8-rot-na 24.95 APE67-dihe-in -71.45, -14.34 -46.11, -40.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 15.874 APE9-dist-in 7.3 None None None XRAY 2.08 0.221 0.265 A 315 296 6 0 0 5 [[999, 1268]] 1.0 3i81 TYR_IGF1R_HUMAN TYR 2.1e-95 324.9 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
5FXSA 980 1286 1367.0 OZN:62290 Type1 Inactive DFGin 6.301 16.461 None -84.33, 164.5 -49.68, 126.88 -62.59, 125.5 294.84, 163.97 82.66, 11.86 out-none out 10.15 Saltbr-none 999.0 HRD-in -72.06, -52.4 79.12, -11.09 none-out-in SNCnoi out-in ActLoopNT-out 14.946 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.25, 115.64 APE9-dihe-in -119.16, 145.07 APE8-dihe-in -79.78, 69.43 APE8-rot-na 32.71 APE67-dihe-in -75.57, -9.31 -55.8, -33.39 APE12-dist-na 18.911 APE11-dist-na 16.798 APE10-dist-na 13.353 APE9-dist-in 6.932 None None None XRAY 1.9 0.183 0.214 A 308 307 0 0 0 0 [[999, 1268]] 1.0 5fxs TYR_IGF1R_HUMAN TYR 6.9e-95 323.2 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3D94A 986 1285 1367.0 D94:60001 Type1.5_Front Inactive DFGin 5.753 12.09 None -113.77, -141.33 -41.63, 115.12 -104.14, 0.25 54.89, 83.46 -78.61, -17.4 out-out out 11.035 Saltbr-out 11.282 HRD-in -72.35, -49.36 78.31, -12.49 out-out-in SNCooi out-in ActLoopNT-out 9.257 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.21, 135.68 APE9-dihe-in -120.98, 133.2 APE8-dihe-in -80.59, 66.97 APE8-rot-na 24.88 APE67-dihe-in -76.95, -9.87 -55.9, -29.5 APE12-dist-na 12.646 APE11-dist-na 8.596 APE10-dist-na 6.456 APE9-dist-in 7.111 None None MHO1142 XRAY 2.3 0.2 0.236 A 301 289 11 0 0 0 [[999, 1268]] 1.0 3d94 TYR_IGF1R_HUMAN TYR 3.2e-95 324.3 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
8PYIAAA 986 1286 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.183 12.51 None -115.76, -140.08 -56.69, 128.49 -118.25, -19.27 59.93, 80.29 -40.9, -38.76 out-out out 10.581 Saltbr-out 8.136 HRD-in -71.36, -56.99 87.46, -13.56 out-out-none SNCoon out-none ActLoopNT-out 8.922 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 111.18 APE9-dihe-in -126.65, 126.64 APE8-dihe-in -81.12, 76.62 APE8-rot-na 35.9 APE67-dihe-in -71.26, -20.53 -54.98, -37.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.172 APE9-dist-in 7.073 None None None XRAY 3.06 0.193 0.235 AAA 321 288 13 0 0 5 [[999, 1268]] 1.0 8pyi TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
8PYIBBB 986 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.22 12.447 None -115.29, -140.05 -57.59, 130.35 -119.47, -19.04 57.6, 81.65 -39.33, -40.51 out-out out 10.581 Saltbr-out 8.138 HRD-in -71.54, -57.15 87.92, -15.23 out-out-none SNCoon out-none ActLoopNT-out 8.993 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 112.31 APE9-dihe-in -126.67, 128.52 APE8-dihe-in -80.09, 76.32 APE8-rot-na 35.62 APE67-dihe-in -70.72, -20.09 -56.2, -36.65 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.11 APE9-dist-in 7.068 None None None XRAY 3.06 0.193 0.235 BBB 321 287 13 0 0 5 [[999, 1268]] 1.0 8pyi TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
8PYICCC 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.166 12.505 None -114.85, -140.89 -57.29, 129.65 -118.38, -19.22 58.71, 80.33 -40.35, -39.19 out-out out 10.547 Saltbr-out 8.078 HRD-in -70.97, -56.86 87.86, -15.93 out-out-in SNCooi out-in ActLoopNT-out 8.949 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -146.69, 116.05 APE9-dihe-in -129.59, 126.27 APE8-dihe-in -80.63, 76.08 APE8-rot-na 36.39 APE67-dihe-in -71.13, -19.68 -54.93, -37.06 APE12-dist-na 999.0 APE11-dist-na 9.653 APE10-dist-na 6.184 APE9-dist-in 7.131 None None None XRAY 3.06 0.193 0.235 CCC 321 286 13 0 0 5 [[999, 1268]] 1.0 8pyi TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
8PYIDDD 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.219 12.459 None -115.04, -139.19 -57.22, 129.11 -118.66, -19.63 58.67, 81.12 -40.31, -39.48 out-out out 10.605 Saltbr-out 8.095 HRD-in -71.24, -57.12 86.84, -13.26 out-out-in SNCooi out-in ActLoopNT-out 8.935 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -91.29, 122.24 APE9-dihe-in -125.14, 125.87 APE8-dihe-in -79.9, 75.59 APE8-rot-na 36.0 APE67-dihe-in -70.95, -19.69 -56.73, -36.41 APE12-dist-na 999.0 APE11-dist-na 9.553 APE10-dist-na 5.986 APE9-dist-in 7.125 None None None XRAY 3.06 0.193 0.235 DDD 321 287 12 0 0 4 [[999, 1268]] 1.0 8pyi TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
8PYIEEE 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.27 12.44 None -115.61, -138.87 -56.86, 128.87 -118.49, -19.41 58.83, 81.0 -40.15, -38.87 out-out out 10.516 Saltbr-out 8.092 HRD-in -71.39, -56.94 87.82, -14.48 out-out-none SNCoon out-none ActLoopNT-out 8.951 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 116.42 APE9-dihe-in -125.67, 127.35 APE8-dihe-in -81.15, 76.83 APE8-rot-na 35.52 APE67-dihe-in -70.81, -19.39 -56.95, -36.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.155 APE9-dist-in 7.113 None None None XRAY 3.06 0.193 0.235 EEE 321 285 14 0 0 6 [[999, 1268]] 1.0 8pyi TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
8PYIFFF 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.31 12.506 None -114.84, -139.12 -57.32, 129.09 -119.24, -19.1 58.43, 80.95 -39.6, -40.34 out-out out 10.562 Saltbr-out 8.089 HRD-in -71.51, -57.69 87.61, -14.16 out-out-in SNCooi out-in ActLoopNT-out 8.913 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -146.97, 119.39 APE9-dihe-in -127.92, 126.81 APE8-dihe-in -81.17, 76.54 APE8-rot-na 34.85 APE67-dihe-in -70.74, -20.02 -56.2, -36.99 APE12-dist-na 14.267 APE11-dist-na 9.704 APE10-dist-na 6.176 APE9-dist-in 7.071 None None None XRAY 3.06 0.193 0.235 FFF 321 287 12 0 0 3 [[999, 1268]] 1.0 8pyi TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
8PYIGGG 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.215 12.411 None -115.39, -138.9 -56.85, 128.81 -118.89, -19.11 58.65, 81.01 -40.57, -39.34 out-out out 10.582 Saltbr-out 8.151 HRD-in -71.45, -56.87 87.79, -13.89 out-out-none SNCoon out-none ActLoopNT-out 8.956 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 115.56 APE9-dihe-in -139.88, 129.5 APE8-dihe-in -81.92, 78.52 APE8-rot-na 36.73 APE67-dihe-in -71.48, -19.02 -54.63, -36.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.313 APE9-dist-in 6.925 None None None XRAY 3.06 0.193 0.235 GGG 321 284 15 0 0 6 [[999, 1268]] 1.0 8pyi TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
8PYIHHH 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.201 12.494 None -116.04, -140.1 -57.52, 129.83 -118.81, -19.1 57.82, 80.84 -40.32, -39.43 out-out out 10.616 Saltbr-out 8.121 HRD-in -71.69, -57.04 87.53, -14.25 out-out-none SNCoon out-none ActLoopNT-out 8.959 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 112.91 APE9-dihe-in -126.66, 127.03 APE8-dihe-in -79.81, 75.92 APE8-rot-na 35.31 APE67-dihe-in -70.25, -19.75 -57.25, -36.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.154 APE9-dist-in 7.165 None None None XRAY 3.06 0.193 0.235 HHH 321 285 14 0 0 5 [[999, 1268]] 1.0 8pyi TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
5HZNA 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.523 11.883 None -122.71, -134.04 -48.48, 117.08 -112.65, 5.39 56.52, 89.56 -80.2, -12.63 out-out out 10.105 Saltbr-out 7.07 HRD-in -68.72, -44.68 74.42, -15.27 out-out-in SNCooi out-in ActLoopNT-out 9.082 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.2, 129.26 APE9-dihe-in -125.1, 113.12 APE8-dihe-in -76.3, 72.6 APE8-rot-na 31.29 APE67-dihe-in -71.82, -14.27 -59.77, -33.09 APE12-dist-na 12.78 APE11-dist-na 9.341 APE10-dist-na 6.003 APE9-dist-in 7.412 E1097A,E1099A None None XRAY 2.2 0.195 0.218 A 304 296 8 0 0 0 [[999, 1268]] 1.0 5hzn TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
5HZNB 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.668 11.698 None -120.23, -145.7 -34.99, 114.07 -109.86, 7.02 53.42, 94.67 -86.81, -17.85 out-out out 10.23 Saltbr-out 7.469 HRD-in -74.79, -42.86 77.21, -19.92 out-out-in SNCooi out-in ActLoopNT-out 8.972 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.8, 127.36 APE9-dihe-in -126.61, 120.91 APE8-dihe-in -82.51, 72.5 APE8-rot-na 31.18 APE67-dihe-in -70.34, -12.61 -56.19, -36.04 APE12-dist-na 12.71 APE11-dist-na 9.436 APE10-dist-na 6.009 APE9-dist-in 7.413 E1097A,E1099A None None XRAY 2.2 0.195 0.218 B 304 296 8 0 0 0 [[999, 1268]] 1.0 5hzn TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
5HZNC 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.504 11.893 None -117.5, -144.25 -35.28, 118.67 -116.54, 5.75 57.58, 87.45 -83.77, -13.7 out-out out 10.205 Saltbr-out 6.568 HRD-in -68.11, -52.05 81.72, -11.87 out-out-in SNCooi out-in ActLoopNT-out 8.979 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.64, 128.06 APE9-dihe-in -121.48, 117.98 APE8-dihe-in -78.81, 67.18 APE8-rot-na 28.39 APE67-dihe-in -73.45, -14.3 -52.08, -33.81 APE12-dist-na 13.032 APE11-dist-na 9.428 APE10-dist-na 6.062 APE9-dist-in 7.275 E1097A,E1099A None None XRAY 2.2 0.195 0.218 C 304 296 8 0 0 0 [[999, 1268]] 1.0 5hzn TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
5HZND 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.586 11.812 None -120.23, -138.34 -41.88, 115.18 -111.54, 6.87 52.55, 90.98 -80.5, -21.29 out-out out 10.156 Saltbr-out 7.057 HRD-in -75.17, -45.42 77.74, -21.01 out-out-in SNCooi out-in ActLoopNT-out 9.098 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.35, 128.86 APE9-dihe-in -120.46, 118.5 APE8-dihe-in -79.97, 71.37 APE8-rot-na 32.37 APE67-dihe-in -73.39, -13.02 -52.14, -35.35 APE12-dist-na 13.179 APE11-dist-na 9.253 APE10-dist-na 6.021 APE9-dist-in 7.453 E1097A,E1099A None None XRAY 2.2 0.195 0.218 D 304 304 0 0 0 0 [[999, 1268]] 1.0 5hzn TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
5HZNE 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.534 11.884 None -122.97, -133.9 -50.03, 120.11 -115.89, 7.06 56.85, 84.61 -81.92, -13.97 out-out out 10.09 Saltbr-out 7.001 HRD-in -71.62, -46.82 77.23, -15.08 out-out-in SNCooi out-in ActLoopNT-out 9.076 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.35, 128.61 APE9-dihe-in -123.88, 113.86 APE8-dihe-in -76.92, 69.0 APE8-rot-na 31.9 APE67-dihe-in -73.44, -14.93 -54.7, -32.97 APE12-dist-na 12.756 APE11-dist-na 9.32 APE10-dist-na 6.009 APE9-dist-in 7.417 E1097A,E1099A None None XRAY 2.2 0.195 0.218 E 304 296 8 0 0 0 [[999, 1268]] 1.0 5hzn TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
5HZNF 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.669 11.686 None -119.91, -143.87 -36.57, 117.22 -111.83, 7.84 53.92, 93.37 -86.48, -19.66 out-out out 10.245 Saltbr-out 7.495 HRD-in -71.54, -45.74 77.92, -19.28 out-out-in SNCooi out-in ActLoopNT-out 8.972 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.77, 125.58 APE9-dihe-in -123.67, 120.15 APE8-dihe-in -81.16, 71.31 APE8-rot-na 31.34 APE67-dihe-in -70.78, -14.02 -54.99, -34.82 APE12-dist-na 12.696 APE11-dist-na 9.431 APE10-dist-na 6.025 APE9-dist-in 7.415 E1097A,E1099A None None XRAY 2.2 0.195 0.218 F 304 296 8 0 0 0 [[999, 1268]] 1.0 5hzn TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
5HZNG 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.495 11.888 None -115.22, -143.92 -37.17, 121.14 -119.03, 5.44 57.57, 87.05 -84.31, -13.87 out-out out 10.212 Saltbr-out 6.568 HRD-in -69.56, -54.08 84.44, -12.44 out-out-in SNCooi out-in ActLoopNT-out 8.999 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.44, 128.11 APE9-dihe-in -122.01, 115.9 APE8-dihe-in -78.8, 69.19 APE8-rot-na 29.58 APE67-dihe-in -71.28, -16.87 -55.78, -34.47 APE12-dist-na 13.018 APE11-dist-na 9.418 APE10-dist-na 6.068 APE9-dist-in 7.312 E1097A,E1099A None None XRAY 2.2 0.195 0.218 G 304 296 8 0 0 0 [[999, 1268]] 1.0 5hzn TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
5HZNH 983 1285 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.564 11.84 None -117.51, -139.77 -40.96, 115.52 -113.35, 4.84 52.59, 91.03 -79.05, -20.18 out-out out 10.169 Saltbr-out 7.132 HRD-in -75.23, -47.04 79.69, -19.55 out-out-in SNCooi out-in ActLoopNT-out 9.113 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.78, 128.57 APE9-dihe-in -119.04, 118.91 APE8-dihe-in -80.75, 73.24 APE8-rot-na 32.94 APE67-dihe-in -74.0, -12.28 -56.22, -33.69 APE12-dist-na 13.184 APE11-dist-na 9.261 APE10-dist-na 6.031 APE9-dist-in 7.449 E1097A,E1099A None None XRAY 2.2 0.195 0.218 H 304 303 0 0 0 0 [[999, 1268]] 1.0 5hzn TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
1M7NA 982 1286 1367.0 No_ligand No_ligand Inactive DFGinter 8.164 7.514 None -63.65, 150.56 -83.71, 161.97 -57.58, 152.8 77.55, 99.86 65.02, 30.98 in-out in 9.867 Saltbr-out 8.828 HRD-in -83.45, -42.46 69.8, -16.63 out-out-in SNCooi out-in ActLoopNT-out 17.622 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.63, 113.99 APE9-dihe-in -128.05, 145.23 APE8-dihe-in -84.3, 65.47 APE8-rot-na 35.92 APE67-dihe-in -74.19, -1.69 -49.75, -32.81 APE12-dist-na 23.243 APE11-dist-na 19.123 APE10-dist-na 15.076 APE9-dist-in 7.467 None None None XRAY 2.7 0.229 0.294 A 322 299 6 0 0 0 [[999, 1268]] 1.0 1m7n TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
1M7NB 982 1286 1367.0 No_ligand No_ligand Inactive DFGinter 9.13 7.337 None -73.47, 167.84 -87.9, 168.41 -62.8, 156.56 81.22, 124.1 55.25, 47.18 in-out in 9.829 Saltbr-out 8.107 HRD-in -100.99, -42.57 66.39, -13.05 out-out-in SNCooi out-in ActLoopNT-out 17.68 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -84.27, 123.84 APE9-dihe-in -122.55, 149.6 APE8-dihe-in -77.03, 59.62 APE8-rot-na 36.33 APE67-dihe-in -67.03, 6.96 -40.27, -45.78 APE12-dist-na 22.981 APE11-dist-na 18.942 APE10-dist-na 15.815 APE9-dist-in 7.184 None None None XRAY 2.7 0.229 0.294 B 322 299 6 0 0 0 [[999, 1268]] 1.0 1m7n TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
1P4OA 978 1285 1367.0 No_ligand No_ligand Inactive DFGinter 8.937 7.453 None -75.61, 161.81 -88.19, 167.58 -62.75, 158.69 79.74, 92.2 58.69, 28.18 in-out in 9.669 Saltbr-out 8.161 HRD-in -85.36, -54.81 81.1, -18.95 out-out-in SNCooi out-in ActLoopNT-out 17.814 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.47, 124.06 APE9-dihe-in -124.38, 139.88 APE8-dihe-in -82.49, 64.57 APE8-rot-na 36.92 APE67-dihe-in -73.19, -6.91 -50.14, -35.0 APE12-dist-na 22.275 APE11-dist-na 18.248 APE10-dist-na 14.541 APE9-dist-in 7.274 E1097A,E1099A None None XRAY 1.5 0.209 0.236 A 322 308 0 0 0 0 [[999, 1268]] 1.0 1p4o TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
1P4OB 977 1290 1367.0 No_ligand No_ligand Inactive DFGinter 8.973 7.373 None -74.95, 163.69 -90.41, 168.58 -63.57, 158.6 80.11, 88.87 59.26, 26.84 in-out in 9.712 Saltbr-out 8.134 HRD-in -85.93, -55.48 81.68, -17.46 out-out-in SNCooi out-in ActLoopNT-out 17.871 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.53, 126.34 APE9-dihe-in -129.41, 143.63 APE8-dihe-in -82.98, 67.29 APE8-rot-na 36.94 APE67-dihe-in -73.89, -4.17 -52.36, -34.34 APE12-dist-na 22.458 APE11-dist-na 18.39 APE10-dist-na 14.695 APE9-dist-in 7.171 E1097A,E1099A None None XRAY 1.5 0.209 0.236 B 322 314 0 0 0 0 [[999, 1268]] 1.0 1p4o TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3LW0A 983 1286 1367.0 CCX:1,CCX:1287 Type3,Allosteric Inactive DFGout 14.069 6.949 BBAminus 170.04, 149.43 -168.43, 165.06 -107.76, 13.31 308.93, 125.37 90.3, 111.78 in-out in 9.111 Saltbr-out 3.854 HRD-in -70.2, -51.48 79.95, -15.38 out-out-in SNCooi out-in ActLoopNT-out 18.456 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.1, 127.88 APE9-dihe-in -120.17, 130.79 APE8-dihe-in -79.59, 68.17 APE8-rot-na 29.74 APE67-dihe-in -72.92, -7.93 -60.62, -32.58 APE12-dist-na 999.0 APE11-dist-na 13.844 APE10-dist-na 9.448 APE9-dist-in 7.294 E1097A,E1099A None None XRAY 1.79 0.157 0.185 A 304 292 12 0 0 3 [[999, 1268]] 1.0 3lw0 TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3LW0B 983 1286 1367.0 CCX:2,CCX:1287 Type3,Allosteric Inactive DFGout 14.11 6.973 BBAminus 170.42, 151.14 -165.86, 166.3 -107.53, 14.79 308.98, 126.2 88.83, 109.35 in-out in 9.031 Saltbr-out 3.852 HRD-in -73.16, -50.06 79.09, -12.99 out-out-in SNCooi out-in ActLoopNT-out 18.441 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.78, 129.68 APE9-dihe-in -120.1, 131.04 APE8-dihe-in -81.08, 67.52 APE8-rot-na 31.55 APE67-dihe-in -72.5, -8.7 -59.87, -33.5 APE12-dist-na 999.0 APE11-dist-na 13.717 APE10-dist-na 9.388 APE9-dist-in 7.263 E1097A,E1099A None None XRAY 1.79 0.157 0.185 B 304 292 12 0 0 3 [[999, 1268]] 1.0 3lw0 TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3LW0C 983 1286 1367.0 CCX:3,CCX:1287 Type3,Allosteric Inactive DFGout 14.138 6.957 BBAminus 171.38, 152.6 -167.31, 165.1 -107.82, 15.64 311.4, 121.85 88.58, 109.58 in-out in 9.103 Saltbr-out 3.922 HRD-in -69.69, -49.88 78.11, -14.34 out-out-in SNCooi out-in ActLoopNT-out 18.417 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.78, 130.13 APE9-dihe-in -121.41, 130.52 APE8-dihe-in -80.7, 68.48 APE8-rot-na 32.26 APE67-dihe-in -71.62, -8.72 -57.24, -35.28 APE12-dist-na 999.0 APE11-dist-na 13.845 APE10-dist-na 9.51 APE9-dist-in 7.27 E1097A,E1099A None None XRAY 1.79 0.157 0.185 C 304 292 12 0 0 3 [[999, 1268]] 1.0 3lw0 TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3O23A 991 1283 1367.0 MQY:1 Type2 Inactive DFGout 19.367 12.672 None -140.99, -145.13 -170.55, 100.68 -44.16, -46.08 195.05, 101.85 38.62, 39.08 out-out out 10.354 Saltbr-out 5.096 HRD-in -68.63, -53.32 81.21, -11.17 out-out-in SNCooi out-in ActLoopNT-out 20.713 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.0, 129.34 APE9-dihe-in -127.06, 143.41 APE8-dihe-in -83.13, 67.71 APE8-rot-na 38.63 APE67-dihe-in -77.97, -3.22 -49.97, -33.61 APE12-dist-na 20.677 APE11-dist-na 15.959 APE10-dist-na 12.623 APE9-dist-in 7.259 Y987F None None XRAY 2.1 0.238 0.278 A 305 293 0 0 0 0 [[999, 1268]] 1.0 3o23 TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
8PYJAAA 986 1270 1367.0 IEA:1301 Type2 Inactive DFGout 17.424 8.106 None -138.01, -167.4 -155.94, 116.33 -112.01, 27.11 203.64, 158.04 64.23, -172.08 in-out in 9.678 Saltbr-out 4.607 HRD-in -63.06, -47.9 63.67, -0.73 out-out-in SNCooi out-in ActLoopNT-out 18.23 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.03, 143.8 APE9-dihe-in -132.6, 135.07 APE8-dihe-in -83.01, 61.81 APE8-rot-na 38.8 APE67-dihe-in -67.3, -20.56 -57.7, -32.48 APE12-dist-na 13.823 APE11-dist-na 9.661 APE10-dist-na 5.585 APE9-dist-in 7.528 None None None XRAY 2.702 0.204 0.302 AAA 321 277 8 0 0 0 [[999, 1268]] 1.0 8pyj TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
8PYKAAA 986 1270 1367.0 IC2:1301 Type2 Inactive DFGout 17.851 9.57 None -133.25, -156.99 -163.59, 105.08 -98.92, 70.17 206.03, 163.97 22.38, -129.27 out-out out 10.195 Saltbr-out 6.356 HRD-in -65.91, -54.94 83.67, -11.11 out-out-in SNCooi out-in ActLoopNT-out 18.256 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.17, 123.86 APE9-dihe-in -113.37, 130.73 APE8-dihe-in -77.02, 69.17 APE8-rot-na 33.02 APE67-dihe-in -67.4, -8.74 -59.14, -35.38 APE12-dist-na 13.709 APE11-dist-na 10.074 APE10-dist-na 6.084 APE9-dist-in 7.185 None None None XRAY 2.23 0.201 0.253 AAA 321 274 11 0 0 0 [[999, 1268]] 1.0 8pyk TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
8PYLAAA 986 1270 1367.0 IE0:1301 Type2 Inactive DFGout 17.49 8.802 None -135.7, -153.05 -170.07, 104.78 -81.37, -21.74 213.38, 146.3 99.88, -176.88 out-out out 10.258 Saltbr-out 5.022 HRD-in -75.5, -46.79 77.95, -4.93 out-out-in SNCooi out-in ActLoopNT-out 18.194 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -61.72, 135.11 APE9-dihe-in -129.69, 131.01 APE8-dihe-in -77.6, 68.98 APE8-rot-na 32.9 APE67-dihe-in -67.64, -16.63 -60.37, -36.74 APE12-dist-na 13.769 APE11-dist-na 9.55 APE10-dist-na 5.581 APE9-dist-in 7.367 None None None XRAY 2.93 0.191 0.249 AAA 321 277 8 0 0 0 [[999, 1268]] 1.0 8pyl TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
8PYMAAA 984 1270 1367.0 IED:1301 Type2 Inactive DFGout 17.388 8.066 None -140.29, -174.19 -150.41, 118.32 -112.85, 8.25 208.87, 151.48 70.27, -164.18 out-out out 10.103 Saltbr-out 5.09 HRD-in -64.19, -38.83 54.72, 11.98 out-out-in SNCooi out-in ActLoopNT-out 18.319 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.12, 139.29 APE9-dihe-in -129.72, 131.76 APE8-dihe-in -83.92, 64.41 APE8-rot-na 36.05 APE67-dihe-in -67.04, -15.79 -60.07, -31.92 APE12-dist-na 13.836 APE11-dist-na 9.654 APE10-dist-na 5.565 APE9-dist-in 7.56 None None None XRAY 2.652 0.24 0.309 AAA 321 278 9 0 0 0 [[999, 1268]] 1.0 8pym TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
8PYNAAA 986 1270 1367.0 ICV:1301 Type2 Inactive DFGout 17.067 8.118 None -134.94, -158.57 -167.15, 119.05 -107.66, 14.53 216.32, 140.82 63.73, -168.46 in-out in 9.719 Saltbr-out 3.706 HRD-in -74.35, -43.01 75.39, -14.56 out-out-in SNCooi out-in ActLoopNT-out 18.077 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.14, 139.88 APE9-dihe-in -133.35, 137.86 APE8-dihe-in -79.24, 67.55 APE8-rot-na 29.6 APE67-dihe-in -72.27, -10.13 -65.45, -29.73 APE12-dist-na 13.949 APE11-dist-na 9.733 APE10-dist-na 5.656 APE9-dist-in 7.462 None None None XRAY 1.71 0.17 0.209 AAA 321 275 10 0 0 0 [[999, 1268]] 1.0 8pyn TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3LW0D 983 1286 1367.0 CCX:4,CCX:1287 Type3,Allosteric Inactive DFGout 14.05 6.878 None 167.75, 151.96 -167.74, 166.55 -109.76, 14.11 305.35, 128.19 89.26, 110.63 in-out in 9.224 Saltbr-out 4.213 HRD-in -71.95, -49.8 77.64, -11.7 out-out-in SNCooi out-in ActLoopNT-out 18.495 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.75, 129.65 APE9-dihe-in -120.75, 130.34 APE8-dihe-in -80.64, 68.25 APE8-rot-na 34.21 APE67-dihe-in -72.08, -8.31 -58.75, -34.0 APE12-dist-na 999.0 APE11-dist-na 13.809 APE10-dist-na 9.457 APE9-dist-in 7.25 E1097A,E1099A None None XRAY 1.79 0.157 0.185 D 304 292 12 0 0 3 [[999, 1268]] 1.0 3lw0 TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
2OJ9A 984 1286 1367.0 BMI:60301 Type1 Inactive None 13.649 18.682 None -109.08, -162.39 -72.97, 149.83 -62.93, 130.5 151.52, 94.1 65.22, -124.89 in-out in 9.905 Saltbr-out 9.511 HRD-in -62.11, -52.47 78.05, -12.6 out-out-in SNCooi out-in ActLoopNT-out 15.423 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.78, 118.25 APE9-dihe-in -124.44, 146.6 APE8-dihe-in -87.28, 67.01 APE8-rot-na 31.6 APE67-dihe-in -78.37, -2.27 -50.93, -32.32 APE12-dist-na 19.952 APE11-dist-na 15.233 APE10-dist-na 11.582 APE9-dist-in 7.287 None None None XRAY 2.0 0.217 0.276 A 307 295 8 0 0 0 [[999, 1268]] 1.0 2oj9 TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
3LVPD 986 1285 1367.0 PDR:4 Type1 None DFGin 6.306 14.427 BLAminus -106.91, 166.93 53.44, 123.0 -131.84, 26.68 301.24, 78.21 -46.25, -39.95 in-in in 9.275 Saltbr-in 3.129 HRD-in -65.98, -38.21 59.59, -1.0 in-in-none SNCiin in-none ActLoopNT-in 2.829 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 78.94 APE8-dihe-in -74.27, 72.81 APE8-rot-na 31.79 APE67-dihe-in -58.26, -9.17 -42.05, -56.15 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.259 None None None XRAY 3.0 0.226 0.279 D 336 282 18 0 0 3 [[999, 1268]] 1.0 3lvp TYR_IGF1R_HUMAN TYR 2.6e-95 324.6 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor

TYR_IGF1R (Insulin-like growth factor 1 receptor)

Total number of chains: 74
Active chains: 2
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 30 40.5% 5FXSA
DFGin ABAminus 24 32.4% 2ZM3A
DFGout None 7 9.5% 3O23A
DFGin BLAminus 4 5.4% AF-P08069-K1A
DFGinter None 4 5.4% 1P4OA
DFGout BBAminus 3 4.1% 3LW0A
DFGin BLBminus 1 1.4% 3QQUA
None None 1 1.4% 2OJ9A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
IGF1R_HUMAN AF-P08069-K1A P08069 991 1276 1367.0 No_ligand No_ligand Active DFGin 6.643 13.608 BLAminus -135.67, -174.5 50.5, 80.19 -91.57, 14.84 300.61, 100.02 -58.88, -30.47 in-in in 8.177 Saltbr-in 2.67 HRD-in -70.7, -43.4 67.54, -16.33 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -57.17, 140.22 APE9-dihe-in -136.38, 138.83 APE8-dihe-in -78.03, 65.53 APE8-rot-na 35.47 APE67-dihe-in -78.02, -11.21 -44.96, -38.15 APE12-dist-na 15.113 APE11-dist-na 10.906 APE10-dist-na 10.15 APE9-dist-in 6.924 None None None AF2 -1.0 1.0 1.0 A 286 286 0 0 0 0 [[999, 1268]] 1.0 AF-P08069-K1 Homo sapiens TYR_IGF1R_HUMAN TYR 1.5e-95 325.4 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN AF-P08069-K3A P08069 991 1276 1367.0 No_ligand No_ligand Active DFGin 6.117 13.053 BLAminus -137.79, -171.74 47.09, 82.9 -94.36, 9.98 307.09, 101.02 -65.96, -22.69 in-in in 8.088 Saltbr-in 2.671 HRD-in -75.6, -44.24 66.53, -10.48 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -53.45, 145.29 APE9-dihe-in -144.44, 141.35 APE8-dihe-in -79.58, 60.38 APE8-rot-na 36.37 APE67-dihe-in -70.79, -12.12 -43.91, -40.05 APE12-dist-na 15.115 APE11-dist-na 11.247 APE10-dist-na 9.947 APE9-dist-in 6.744 None None None AF2 -1.0 1.0 1.0 A 286 286 0 0 0 0 [[999, 1268]] 1.0 AF-P08069-K3 Homo sapiens TYR_IGF1R_HUMAN TYR 1.5e-95 325.4 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 1K3AA P08069 988 1286 1367.0 ACP:60300 ATPlike Inactive DFGin 6.326 14.213 ABAminus -128.41, -4.91 -126.86, 131.72 -125.9, 30.62 307.04, 99.18 -55.79, -30.44 in-out in 9.005 Saltbr-out 4.763 HRD-in -68.21, -48.33 72.95, -10.46 out-in-in SNCoii in-in ActLoopNT-in 2.922 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -92.81, 106.37 APE9-dihe-in -118.2, 152.14 APE8-dihe-in -73.75, 68.45 APE8-rot-na 35.41 APE67-dihe-in -73.37, -1.85 -44.97, -44.15 APE12-dist-na 15.179 APE11-dist-na 11.105 APE10-dist-na 10.844 APE9-dist-in 7.129 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.1 0.212 0.251 A 299 291 8 0 0 0 [[999, 1268]] 1.0 1k3a Homo sapiens TYR_IGF1R_HUMAN TYR 3.1e-95 324.3 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 2ZM3A P08069 981 1285 1367.0 575:60001 Type1 Inactive DFGin 6.789 15.505 ABAminus -126.6, 3.02 -143.72, 130.04 -129.16, 19.26 296.34, 90.11 -55.9, -25.14 in-out in 9.527 Saltbr-out 4.852 HRD-in -72.76, -50.33 77.45, -5.62 out-in-out SNCoio in-out ActLoopNT-in 3.048 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -118.76, 9.6 APE9-dihe-in -63.6, 138.6 APE8-dihe-in -67.76, 134.68 APE8-rot-na 23.16 APE67-dihe-in -69.69, -0.78 -61.9, -34.84 APE12-dist-na 13.645 APE11-dist-na 9.848 APE10-dist-na 9.225 APE9-dist-in 5.645 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.5 0.204 0.257 A 308 302 3 0 0 0 [[999, 1268]] 1.0 2zm3 Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 2ZM3B P08069 981 1285 1367.0 575:60001 Type1 Inactive DFGin 6.898 15.542 ABAminus -122.17, -30.49 -117.45, 117.57 -113.54, 25.96 293.65, 87.06 -63.47, -21.66 in-out in 9.271 Saltbr-out 4.722 HRD-in -70.83, -52.07 75.8, -5.9 out-in-out SNCoio in-out ActLoopNT-in 2.903 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -116.67, 22.47 APE9-dihe-in -72.91, 143.81 APE8-dihe-in -66.5, 133.93 APE8-rot-na 346.04 APE67-dihe-in -76.24, -7.5 -59.54, -34.53 APE12-dist-na 13.473 APE11-dist-na 9.742 APE10-dist-na 9.363 APE9-dist-in 5.867 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.5 0.204 0.257 B 308 298 7 0 0 0 [[999, 1268]] 1.0 2zm3 Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 2ZM3C P08069 981 1285 1367.0 575:60001 Type1 Inactive DFGin 6.947 15.802 ABAminus -152.06, 34.97 -157.73, 111.59 -117.56, 21.8 294.76, 97.45 -67.22, -1.53 in-out in 9.294 Saltbr-out 4.566 HRD-in -77.37, -44.24 69.01, -4.52 out-in-out SNCoio in-out ActLoopNT-in 2.914 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -140.21, 38.41 APE9-dihe-in -71.06, 141.9 APE8-dihe-in -59.24, 134.31 APE8-rot-na 17.13 APE67-dihe-in -70.15, -0.4 -63.02, -34.83 APE12-dist-na 13.912 APE11-dist-na 9.841 APE10-dist-na 10.352 APE9-dist-in 5.839 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.5 0.204 0.257 C 308 298 7 0 0 0 [[999, 1268]] 1.0 2zm3 Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 2ZM3D P08069 981 1285 1367.0 575:60001 Type1 Inactive DFGin 6.824 15.051 ABAminus -111.39, -39.63 -105.46, 131.68 -127.13, 27.77 299.55, 96.91 -65.49, -19.62 in-out in 9.687 Saltbr-out 5.274 HRD-in -74.05, -49.11 76.32, -10.43 out-in-out SNCoio in-out ActLoopNT-in 2.901 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -119.17, 22.3 APE9-dihe-in -75.96, 143.16 APE8-dihe-in -66.16, 129.67 APE8-rot-na 349.87 APE67-dihe-in -74.71, -7.32 -58.83, -32.73 APE12-dist-na 13.653 APE11-dist-na 9.739 APE10-dist-na 9.3 APE9-dist-in 5.836 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.5 0.204 0.257 D 308 295 10 0 0 0 [[999, 1268]] 1.0 2zm3 Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3LVPA P08069 989 1286 1367.0 PDR:1 Type1 Inactive DFGin 6.057 14.189 ABAminus -121.12, 43.14 -157.44, 127.28 -132.71, 38.65 304.97, 81.73 -58.62, -41.18 in-out in 9.113 Saltbr-out 6.234 HRD-in -83.6, -34.91 64.8, -16.89 out-in-in SNCoii in-in ActLoopNT-in 3.21 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.15, 163.21 APE9-dihe-in -98.5, 148.37 APE8-dihe-in -75.76, 55.82 APE8-rot-na 35.7 APE67-dihe-in -60.82, -13.12 -37.4, -57.84 APE12-dist-na 11.81 APE11-dist-na 10.859 APE10-dist-na 12.555 APE9-dist-in 7.769 None None None XRAY 3.0 0.226 0.279 A 336 289 9 0 0 7 [[999, 1268]] 1.0 3lvp Homo sapiens TYR_IGF1R_HUMAN TYR 2.6e-95 324.6 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3LVPB P08069 986 1285 1367.0 PDR:2 Type1 Inactive DFGin 5.929 13.658 ABAminus -100.72, -41.98 -105.19, 149.94 -137.93, 21.74 308.71, 87.7 -51.11, -10.36 in-out in 9.376 Saltbr-out 4.699 HRD-in -75.05, -36.77 62.12, -0.15 out-in-in SNCoii in-in ActLoopNT-in 2.801 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -133.19, 147.36 APE9-dihe-in -73.98, 133.27 APE8-dihe-in -70.94, 67.87 APE8-rot-na 28.67 APE67-dihe-in -66.44, 0.67 -51.66, -49.49 APE12-dist-na 12.766 APE11-dist-na 10.848 APE10-dist-na 12.443 APE9-dist-in 7.627 None None None XRAY 3.0 0.226 0.279 B 336 295 5 0 0 0 [[999, 1268]] 1.0 3lvp Homo sapiens TYR_IGF1R_HUMAN TYR 2.6e-95 324.6 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3LVPC P08069 987 1286 1367.0 PDR:3 Type1 Inactive DFGin 6.602 14.705 ABAminus -128.34, 8.64 -136.7, 135.21 -140.34, 37.76 307.43, 72.91 -60.45, -40.08 in-out in 9.777 Saltbr-out 5.735 HRD-in -80.86, -39.6 60.48, 1.48 out-in-out SNCoio in-out ActLoopNT-in 3.067 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 53.07, 146.43 APE9-dihe-in -156.81, 103.94 APE8-dihe-in -81.83, 74.27 APE8-rot-na 32.03 APE67-dihe-in -72.67, -15.88 -39.8, -39.1 APE12-dist-na 7.873 APE11-dist-na 8.677 APE10-dist-na 7.38 APE9-dist-in 7.06 None None None XRAY 3.0 0.226 0.279 C 336 293 7 0 0 2 [[999, 1268]] 1.0 3lvp Homo sapiens TYR_IGF1R_HUMAN TYR 2.6e-95 324.6 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3F5PA P08069 981 1286 1367.0 741:60001 Type1.5_Front Inactive DFGin 6.61 16.748 ABAminus -138.06, -25.59 -129.58, 107.73 -116.06, 43.16 310.54, 93.03 -78.83, -11.08 out-out out 11.275 Saltbr-out 6.906 HRD-in -67.38, -43.83 73.05, -28.09 out-in-out SNCoio in-out ActLoopNT-in 2.971 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.2, 9.43 APE9-dihe-in -62.84, 138.01 APE8-dihe-in -63.08, 132.26 APE8-rot-na 338.19 APE67-dihe-in -72.6, -14.18 -69.93, -24.15 APE12-dist-na 13.896 APE11-dist-na 10.264 APE10-dist-na 9.82 APE9-dist-in 6.264 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 A 308 301 5 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3F5PB P08069 981 1286 1367.0 741:60002 Type1.5_Front Inactive DFGin 6.74 16.774 ABAminus -147.75, -6.76 -126.37, 106.72 -113.94, 18.15 303.38, 100.96 -63.88, -6.59 out-out out 11.005 Saltbr-out 7.016 HRD-in -75.04, -39.09 66.41, -28.14 out-in-out SNCoio in-out ActLoopNT-in 2.98 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.44, 30.24 APE9-dihe-in -71.55, 137.53 APE8-dihe-in -59.54, 131.44 APE8-rot-na 338.8 APE67-dihe-in -62.32, -22.71 -80.06, -23.54 APE12-dist-na 13.869 APE11-dist-na 10.125 APE10-dist-na 10.151 APE9-dist-in 6.368 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 B 308 300 6 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3F5PC P08069 981 1286 1367.0 741:60003 Type1.5_Front Inactive DFGin 6.476 16.508 ABAminus -131.28, -29.71 -123.17, 122.2 -124.32, 31.59 310.58, 97.96 -71.28, -4.47 out-out out 11.326 Saltbr-out 7.151 HRD-in -67.89, -44.01 69.59, -29.8 out-in-out SNCoio in-out ActLoopNT-in 2.929 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.67, 21.52 APE9-dihe-in -66.68, 135.08 APE8-dihe-in -55.37, 125.9 APE8-rot-na 335.16 APE67-dihe-in -63.64, -20.63 -71.03, -23.62 APE12-dist-na 13.947 APE11-dist-na 10.314 APE10-dist-na 10.017 APE9-dist-in 6.347 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 C 308 303 3 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3F5PD P08069 981 1286 1367.0 741:60004 Type1.5_Front Inactive DFGin 6.691 16.948 ABAminus -123.55, -41.41 -120.41, 118.96 -120.72, 27.37 304.28, 99.29 -67.93, -13.37 out-out out 11.466 Saltbr-out 7.444 HRD-in -72.44, -43.38 70.69, -28.87 out-in-out SNCoio in-out ActLoopNT-in 2.922 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -114.64, 11.87 APE9-dihe-in -60.75, 136.9 APE8-dihe-in -61.78, 130.42 APE8-rot-na 20.36 APE67-dihe-in -67.44, -13.84 -72.23, -24.66 APE12-dist-na 13.872 APE11-dist-na 10.33 APE10-dist-na 10.049 APE9-dist-in 6.368 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 D 308 299 7 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3F5PE P08069 981 1285 1367.0 741:60005 Type1.5_Front Inactive DFGin 6.694 16.82 ABAminus -135.52, -29.09 -118.77, 122.15 -123.6, 9.7 296.44, 108.3 -57.57, -18.08 out-out out 11.069 Saltbr-out 7.271 HRD-in -68.6, -42.13 69.21, -24.51 out-in-out SNCoio in-out ActLoopNT-in 2.855 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -119.4, 7.14 APE9-dihe-in -54.67, 137.93 APE8-dihe-in -65.35, 131.07 APE8-rot-na 341.16 APE67-dihe-in -64.5, -10.68 -68.92, -32.58 APE12-dist-na 14.021 APE11-dist-na 10.452 APE10-dist-na 10.148 APE9-dist-in 6.28 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 E 308 301 4 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3F5PF P08069 981 1285 1367.0 741:60006 Type1.5_Front Inactive DFGin 6.483 16.672 ABAminus -133.64, -29.08 -124.95, 116.76 -119.73, 22.12 307.37, 101.54 -62.11, -21.12 out-out out 11.456 Saltbr-out 7.439 HRD-in -66.51, -41.75 69.88, -16.79 out-in-out SNCoio in-out ActLoopNT-in 2.973 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.91, 14.58 APE9-dihe-in -64.37, 136.64 APE8-dihe-in -51.49, 126.07 APE8-rot-na 332.53 APE67-dihe-in -71.57, -11.29 -75.66, -21.34 APE12-dist-na 14.067 APE11-dist-na 10.393 APE10-dist-na 10.014 APE9-dist-in 6.14 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 F 308 301 4 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3F5PG P08069 981 1285 1367.0 741:60007 Type1.5_Front Inactive DFGin 6.83 16.816 ABAminus -142.79, -22.58 -124.37, 117.71 -119.99, 31.05 299.76, 104.87 -73.83, -11.77 out-out out 11.313 Saltbr-out 7.0 HRD-in -78.88, -44.79 72.24, -24.62 out-in-out SNCoio in-out ActLoopNT-in 2.969 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -107.94, 24.79 APE9-dihe-in -73.02, 139.57 APE8-dihe-in -63.97, 132.91 APE8-rot-na 337.39 APE67-dihe-in -71.97, -5.77 -75.29, -20.42 APE12-dist-na 14.012 APE11-dist-na 10.239 APE10-dist-na 9.892 APE9-dist-in 6.221 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 G 308 301 4 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3F5PH P08069 981 1286 1367.0 741:60008 Type1.5_Front Inactive DFGin 6.629 16.429 ABAminus -135.18, -37.61 -123.09, 112.94 -114.78, 16.78 310.03, 93.21 -57.54, -9.93 out-out out 11.26 Saltbr-out 7.542 HRD-in -79.51, -41.44 75.33, -29.75 out-in-out SNCoio in-out ActLoopNT-in 2.981 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.47, 10.93 APE9-dihe-in -59.95, 134.42 APE8-dihe-in -57.02, 119.96 APE8-rot-na 332.96 APE67-dihe-in -72.4, -8.79 -61.06, -25.16 APE12-dist-na 14.198 APE11-dist-na 10.466 APE10-dist-na 10.185 APE9-dist-in 6.401 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 H 308 301 5 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3F5PI P08069 981 1285 1367.0 741:60009 Type1.5_Front Inactive DFGin 6.637 16.461 ABAminus -144.33, -12.52 -125.22, 113.79 -116.99, 15.78 300.54, 108.07 -62.21, -14.24 out-out out 10.889 Saltbr-out 6.889 HRD-in -60.61, -42.68 67.93, -23.46 out-in-out SNCoio in-out ActLoopNT-in 2.917 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.73, 15.28 APE9-dihe-in -67.33, 139.53 APE8-dihe-in -63.65, 128.86 APE8-rot-na 345.01 APE67-dihe-in -68.57, -17.49 -69.06, -21.27 APE12-dist-na 13.914 APE11-dist-na 10.23 APE10-dist-na 9.797 APE9-dist-in 6.228 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 I 308 296 9 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3F5PJ P08069 981 1285 1367.0 741:60010 Type1.5_Front Inactive DFGin 6.647 16.713 ABAminus -137.35, -22.07 -131.76, 119.09 -115.56, 22.57 300.22, 101.26 -61.94, -18.78 out-out out 10.94 Saltbr-out 6.672 HRD-in -74.88, -41.95 72.95, -30.32 out-in-out SNCoio in-out ActLoopNT-in 2.964 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -114.55, 26.2 APE9-dihe-in -76.04, 131.14 APE8-dihe-in -47.14, 118.18 APE8-rot-na 11.41 APE67-dihe-in -74.24, -9.54 -60.76, -20.49 APE12-dist-na 14.276 APE11-dist-na 10.237 APE10-dist-na 10.205 APE9-dist-in 6.46 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 J 308 295 10 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3F5PK P08069 981 1285 1367.0 741:60011 Type1.5_Front Inactive DFGin 6.407 16.547 ABAminus -137.37, -28.84 -124.99, 120.18 -119.7, 16.02 301.42, 102.62 -59.26, -20.51 out-out out 11.163 Saltbr-out 6.697 HRD-in -69.13, -50.03 76.13, -25.52 out-in-out SNCoio in-out ActLoopNT-in 2.956 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -116.66, 8.96 APE9-dihe-in -58.52, 142.15 APE8-dihe-in -59.15, 129.43 APE8-rot-na 338.61 APE67-dihe-in -60.69, -25.24 -69.7, -27.83 APE12-dist-na 14.114 APE11-dist-na 10.152 APE10-dist-na 9.947 APE9-dist-in 6.405 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 K 308 295 10 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3F5PL P08069 981 1285 1367.0 741:60013 Type1.5_Front Inactive DFGin 6.56 16.394 ABAminus -130.09, -30.53 -132.5, 115.28 -114.91, 24.81 310.05, 96.63 -62.07, -19.46 out-out out 11.029 Saltbr-out 6.97 HRD-in -66.51, -50.25 76.73, -28.84 out-in-out SNCoio in-out ActLoopNT-in 2.868 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.68, 19.75 APE9-dihe-in -67.29, 128.45 APE8-dihe-in -49.93, 126.32 APE8-rot-na 13.1 APE67-dihe-in -68.28, -21.28 -70.5, -21.67 APE12-dist-na 14.19 APE11-dist-na 10.315 APE10-dist-na 10.171 APE9-dist-in 6.356 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 L 308 295 10 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3F5PM P08069 981 1285 1367.0 741:60012 Type1.5_Front Inactive DFGin 6.771 16.613 ABAminus -128.57, -42.47 -122.66, 116.51 -120.09, 38.47 314.34, 94.44 -73.17, -23.07 out-out out 11.214 Saltbr-out 7.332 HRD-in -78.25, -49.69 75.71, -26.22 out-in-out SNCoio in-out ActLoopNT-in 2.877 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.51, 9.39 APE9-dihe-in -60.52, 138.49 APE8-dihe-in -61.63, 125.4 APE8-rot-na 341.15 APE67-dihe-in -68.1, -5.47 -67.37, -25.72 APE12-dist-na 13.872 APE11-dist-na 10.161 APE10-dist-na 9.914 APE9-dist-in 6.394 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 M 308 297 8 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3F5PR P08069 981 1285 1367.0 741:60014 Type1.5_Front Inactive DFGin 6.538 16.629 ABAminus -139.04, -20.87 -125.55, 103.39 -109.5, 25.04 311.13, 96.42 -58.59, -20.19 out-out out 11.106 Saltbr-out 7.253 HRD-in -61.08, -46.93 71.37, -30.05 out-in-out SNCoio in-out ActLoopNT-in 2.994 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -121.06, 13.96 APE9-dihe-in -63.18, 134.5 APE8-dihe-in -57.6, 125.54 APE8-rot-na 338.75 APE67-dihe-in -68.47, -18.65 -66.66, -22.95 APE12-dist-na 14.134 APE11-dist-na 10.186 APE10-dist-na 10.002 APE9-dist-in 6.439 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 R 308 296 9 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3F5PS P08069 981 1286 1367.0 741:60015 Type1.5_Front Inactive DFGin 6.621 16.362 ABAminus -137.74, -25.34 -122.78, 115.95 -115.05, 8.88 304.38, 111.51 -47.71, -27.84 out-out out 11.103 Saltbr-out 6.886 HRD-in -69.09, -43.99 64.64, -15.6 out-in-out SNCoio in-out ActLoopNT-in 2.902 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -120.58, 17.02 APE9-dihe-in -62.27, 136.85 APE8-dihe-in -61.63, 122.69 APE8-rot-na 21.86 APE67-dihe-in -66.47, -21.61 -67.46, -19.45 APE12-dist-na 13.986 APE11-dist-na 10.237 APE10-dist-na 10.157 APE9-dist-in 6.245 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 S 308 297 9 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3F5PT P08069 981 1286 1367.0 741:60016 Type1.5_Front Inactive DFGin 6.52 16.375 ABAminus -141.26, -19.49 -137.77, 101.2 -103.13, 11.95 304.34, 96.76 -50.98, -21.44 out-out out 10.787 Saltbr-out 6.707 HRD-in -77.18, -39.29 69.12, -25.78 out-in-out SNCoio in-out ActLoopNT-in 2.859 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -114.42, 13.71 APE9-dihe-in -68.71, 130.72 APE8-dihe-in -54.94, 124.12 APE8-rot-na 340.88 APE67-dihe-in -66.19, -17.17 -61.43, -26.74 APE12-dist-na 13.846 APE11-dist-na 10.239 APE10-dist-na 9.88 APE9-dist-in 6.273 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 T 308 297 9 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3QQUC P08069 989 1285 1367.0 01P:60001 Type1 Inactive DFGin 8.318 16.87 BLAminus -97.01, 150.34 14.49, 98.68 -65.56, 26.06 281.91, 75.71 -140.07, 16.5 in-in in 9.191 Saltbr-in 3.594 HRD-out -77.97, 136.61 -108.26, 0.31 in-out-in SNCioi out-in ActLoopNT-out 16.858 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.41, 127.29 APE9-dihe-in -133.08, 155.06 APE8-dihe-in -87.24, 64.19 APE8-rot-na 38.0 APE67-dihe-in -67.35, -9.92 -53.34, -43.26 APE12-dist-na 22.831 APE11-dist-na 18.041 APE10-dist-na 14.399 APE9-dist-in 7.438 None None None XRAY 2.9 0.273 0.302 C 301 293 4 0 0 0 [[999, 1268]] 1.0 3qqu Homo sapiens TYR_IGF1R_HUMAN TYR 1.8e-95 325.1 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3QQUA P08069 991 1285 1367.0 01P:60001 Type1 Inactive DFGin 7.018 15.778 BLBminus -115.26, 159.62 28.18, 96.19 -42.42, 112.88 288.43, 150.16 68.34, -45.79 in-out in 9.091 Saltbr-out 5.093 HRD-out -66.07, 145.48 -122.95, 8.59 out-out-in SNCooi out-in ActLoopNT-out 16.955 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.25, 118.57 APE9-dihe-in -132.55, 144.54 APE8-dihe-in -85.92, 76.47 APE8-rot-na 33.89 APE67-dihe-in -71.18, -0.86 -64.59, -36.6 APE12-dist-na 20.861 APE11-dist-na 16.489 APE10-dist-na 12.487 APE9-dist-in 7.354 None None None XRAY 2.9 0.273 0.302 A 301 285 10 0 0 0 [[999, 1268]] 1.0 3qqu Homo sapiens TYR_IGF1R_HUMAN TYR 1.8e-95 325.1 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 1JQHA P08069 984 1286 1367.0 ANP:301 ATPlike Inactive DFGin 5.69 16.569 None -66.7, 163.88 -59.45, 151.32 -140.18, 178.07 43.94, 89.38 -106.76, 173.06 in-out in 9.977 Saltbr-out 6.056 HRD-in -50.88, -56.96 74.77, -3.78 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -84.24, 106.81 APE9-dihe-in -58.88, 134.76 APE8-dihe-in -78.96, 121.64 APE8-rot-na 37.96 APE67-dihe-in -60.45, -7.73 -52.46, -43.95 APE12-dist-na 7.157 APE11-dist-na 11.3 APE10-dist-na 15.597 APE9-dist-in 5.8 E979G,Y980S None None XRAY 2.1 0.195 0.219 A 308 291 12 0 0 7 [[999, 1268]] 1.0 1jqh Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 1JQHB P08069 984 1286 1367.0 ANP:302 ATPlike Inactive DFGin 5.687 16.554 None -65.78, 164.4 -59.98, 151.89 -140.81, 178.2 43.68, 89.42 -109.69, -174.77 in-out in 9.988 Saltbr-out 6.019 HRD-in -51.69, -56.66 74.32, -2.97 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.6, 107.67 APE9-dihe-in -58.75, 135.36 APE8-dihe-in -79.54, 122.52 APE8-rot-na 37.69 APE67-dihe-in -59.25, -7.46 -52.18, -45.28 APE12-dist-na 6.817 APE11-dist-na 10.932 APE10-dist-na 15.216 APE9-dist-in 5.768 E979G,Y980S None None XRAY 2.1 0.195 0.219 B 308 287 16 0 0 7 [[999, 1268]] 1.0 1jqh Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 1JQHC P08069 984 1286 1367.0 ANP:303 ATPlike Inactive DFGin 5.698 16.558 None -65.47, 162.73 -58.75, 151.62 -140.8, 179.03 43.87, 88.98 -110.24, -177.72 in-out in 9.999 Saltbr-out 6.035 HRD-in -53.2, -57.0 74.59, -2.63 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.9, 107.89 APE9-dihe-in -58.88, 134.76 APE8-dihe-in -79.04, 122.75 APE8-rot-na 38.27 APE67-dihe-in -60.34, -8.42 -53.61, -43.61 APE12-dist-na 6.926 APE11-dist-na 10.986 APE10-dist-na 15.245 APE9-dist-in 5.774 E979G,Y980S None None XRAY 2.1 0.195 0.219 C 308 291 12 0 0 7 [[999, 1268]] 1.0 1jqh Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3QQUB P08069 988 1286 1367.0 01P:60001 Type1 Inactive DFGin 7.313 15.849 None -33.42, 160.47 -37.99, 116.49 -33.99, 105.39 285.12, 147.4 61.19, -16.27 in-out in 9.14 Saltbr-out 5.132 HRD-out -74.87, 134.07 -112.64, 23.07 out-out-in SNCooi out-in ActLoopNT-out 16.45 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.73, 125.53 APE9-dihe-in -129.43, 153.07 APE8-dihe-in -94.91, 67.38 APE8-rot-na 36.24 APE67-dihe-in -82.46, 4.52 -51.63, -28.48 APE12-dist-na 20.873 APE11-dist-na 16.306 APE10-dist-na 12.631 APE9-dist-in 7.052 None None None XRAY 2.9 0.273 0.302 B 301 288 11 0 0 0 [[999, 1268]] 1.0 3qqu Homo sapiens TYR_IGF1R_HUMAN TYR 1.8e-95 325.1 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3QQUD P08069 989 1285 1367.0 01P:60001 Type1 Inactive DFGin 7.865 16.342 None -72.27, 173.4 -41.63, 112.37 -69.49, 2.91 294.86, 82.49 -113.94, 14.31 in-out in 9.33 Saltbr-out 4.332 HRD-out -89.46, 130.4 -100.59, 1.17 out-out-out SNCooo out-out ActLoopNT-out 17.365 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 71.55, 69.22 APE9-dihe-in -124.37, 159.91 APE8-dihe-in -89.12, 68.21 APE8-rot-na 38.62 APE67-dihe-in -73.08, -17.7 -59.12, -27.53 APE12-dist-na 21.94 APE11-dist-na 19.125 APE10-dist-na 15.188 APE9-dist-in 7.458 None None None XRAY 2.9 0.273 0.302 D 301 292 5 0 0 0 [[999, 1268]] 1.0 3qqu Homo sapiens TYR_IGF1R_HUMAN TYR 1.8e-95 325.1 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 4D2RA P08069 985 1286 1367.0 DYK:2288 Type1 Inactive DFGin 6.17 16.203 None -69.68, 163.13 -53.49, 135.63 -66.9, 144.51 304.26, 163.38 61.31, 29.83 out-out out 10.267 Saltbr-out 6.647 HRD-in -70.04, -49.33 73.87, -13.98 out-out-in SNCooi out-in ActLoopNT-out 17.489 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.92, 112.08 APE9-dihe-in -125.82, 147.19 APE8-dihe-in -85.98, 69.81 APE8-rot-na 32.75 APE67-dihe-in -73.08, -8.74 -50.8, -35.19 APE12-dist-na 21.901 APE11-dist-na 17.034 APE10-dist-na 13.417 APE9-dist-in 7.156 None None None XRAY 2.1 0.181 0.221 A 302 300 2 0 0 2 [[999, 1268]] 1.0 4d2r Homo sapiens TYR_IGF1R_HUMAN TYR 1.8e-95 325.1 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3NW5A P08069 985 1286 1367.0 LGX:60001 Type1 Inactive DFGin 6.696 16.886 None -72.74, 167.89 -46.3, 134.17 -70.68, 160.99 291.97, 0.43 38.79, 22.82 out-out out 10.246 Saltbr-out 5.611 HRD-in -64.28, -52.64 77.7, -10.43 out-out-in SNCooi out-in ActLoopNT-out 16.559 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.81, 115.11 APE9-dihe-in -124.48, 143.18 APE8-dihe-in -78.32, 63.38 APE8-rot-na 28.02 APE67-dihe-in -71.11, -14.08 -47.07, -38.36 APE12-dist-na 20.295 APE11-dist-na 16.099 APE10-dist-na 12.81 APE9-dist-in 7.362 None None None XRAY 2.14 0.196 0.254 A 307 302 0 0 0 0 [[999, 1268]] 1.0 3nw5 Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3NW6A P08069 986 1286 1367.0 LGW:60001 Type1 Inactive DFGin 6.379 16.329 None -74.88, 163.27 -46.43, 132.32 -66.66, 145.01 298.3, 172.57 60.37, 24.67 out-out out 10.116 Saltbr-out 5.223 HRD-in -71.12, -48.14 76.3, -15.79 out-out-in SNCooi out-in ActLoopNT-out 18.224 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.0, 97.67 APE9-dihe-in -118.49, 154.77 APE8-dihe-in -81.27, 69.63 APE8-rot-na 32.94 APE67-dihe-in -72.42, -10.33 -48.22, -40.81 APE12-dist-na 17.163 APE11-dist-na 16.709 APE10-dist-na 13.655 APE9-dist-in 7.171 None None None XRAY 2.2 0.184 0.253 A 307 301 0 0 0 0 [[999, 1268]] 1.0 3nw6 Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3NW7A P08069 987 1286 1367.0 LGV:60001 Type1 Inactive DFGin 5.914 15.618 None -79.79, -167.52 -73.83, 143.18 -76.01, 139.22 303.93, 155.83 55.33, 50.19 in-out in 9.95 Saltbr-out 6.831 HRD-in -73.07, -47.61 73.35, -7.71 out-out-in SNCooi out-in ActLoopNT-out 15.576 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.1, 112.82 APE9-dihe-in -110.42, 135.27 APE8-dihe-in -85.88, 69.94 APE8-rot-na 27.32 APE67-dihe-in -72.04, -10.86 -50.71, -38.46 APE12-dist-na 999.0 APE11-dist-na 15.926 APE10-dist-na 11.794 APE9-dist-in 7.466 None None None XRAY 2.11 0.168 0.226 A 307 297 3 0 0 3 [[999, 1268]] 1.0 3nw7 Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 5FXQA P08069 980 1286 1367.0 GD5:62287 Type1 Inactive DFGin 6.15 16.395 None -75.24, 161.17 -49.54, 127.03 -61.92, 123.0 295.29, 167.93 87.57, 25.79 out-out out 10.492 Saltbr-out 7.924 HRD-in -76.32, -54.31 77.35, -9.89 out-out-in SNCooi out-in ActLoopNT-out 15.064 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.4, 114.95 APE9-dihe-in -123.96, 146.04 APE8-dihe-in -82.98, 67.94 APE8-rot-na 28.97 APE67-dihe-in -76.69, -10.66 -53.34, -32.39 APE12-dist-na 999.0 APE11-dist-na 16.72 APE10-dist-na 13.032 APE9-dist-in 7.148 None None None XRAY 2.3 999.0 0.275 A 308 301 6 0 0 3 [[999, 1268]] 1.0 5fxq Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 5FXRA P08069 980 1283 1367.0 8LN:62284 Type1 Inactive DFGin 6.364 16.559 None -71.13, 158.45 -48.25, 129.23 -64.15, 116.2 296.93, 166.85 93.0, 19.74 out-out out 10.539 Saltbr-out 7.176 HRD-in -75.83, -55.57 82.75, -12.94 out-out-in SNCooi out-in ActLoopNT-out 15.258 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.77, 112.68 APE9-dihe-in -129.53, 148.37 APE8-dihe-in -86.54, 69.56 APE8-rot-na 33.95 APE67-dihe-in -74.34, -9.8 -55.93, -31.36 APE12-dist-na 999.0 APE11-dist-na 17.455 APE10-dist-na 13.75 APE9-dist-in 7.242 None None None XRAY 2.4 0.23 0.294 A 308 299 4 0 0 3 [[999, 1268]] 1.0 5fxr Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3I81A P08069 985 1286 1367.0 EBI:60201 Type1 Inactive DFGin 6.688 15.783 None -69.56, 174.65 -71.05, 142.28 -76.41, 136.92 311.88, 126.84 70.68, 14.21 out-out out 10.216 Saltbr-out 5.618 HRD-in -62.27, -48.86 72.23, -18.63 out-out-none SNCoon out-none ActLoopNT-out 16.975 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -54.18 APE9-dihe-in -126.35, 139.61 APE8-dihe-in -88.27, 72.05 APE8-rot-na 24.95 APE67-dihe-in -71.45, -14.34 -46.11, -40.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 15.874 APE9-dist-in 7.3 None None None XRAY 2.08 0.221 0.265 A 315 296 6 0 0 5 [[999, 1268]] 1.0 3i81 Homo sapiens TYR_IGF1R_HUMAN TYR 2.1e-95 324.9 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 5FXSA P08069 980 1286 1367.0 OZN:62290 Type1 Inactive DFGin 6.301 16.461 None -84.33, 164.5 -49.68, 126.88 -62.59, 125.5 294.84, 163.97 82.66, 11.86 out-none out 10.15 Saltbr-none 999.0 HRD-in -72.06, -52.4 79.12, -11.09 none-out-in SNCnoi out-in ActLoopNT-out 14.946 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.25, 115.64 APE9-dihe-in -119.16, 145.07 APE8-dihe-in -79.78, 69.43 APE8-rot-na 32.71 APE67-dihe-in -75.57, -9.31 -55.8, -33.39 APE12-dist-na 18.911 APE11-dist-na 16.798 APE10-dist-na 13.353 APE9-dist-in 6.932 None None None XRAY 1.9 0.183 0.214 A 308 307 0 0 0 0 [[999, 1268]] 1.0 5fxs Homo sapiens TYR_IGF1R_HUMAN TYR 6.9e-95 323.2 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3D94A P08069 986 1285 1367.0 D94:60001 Type1.5_Front Inactive DFGin 5.753 12.09 None -113.77, -141.33 -41.63, 115.12 -104.14, 0.25 54.89, 83.46 -78.61, -17.4 out-out out 11.035 Saltbr-out 11.282 HRD-in -72.35, -49.36 78.31, -12.49 out-out-in SNCooi out-in ActLoopNT-out 9.257 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.21, 135.68 APE9-dihe-in -120.98, 133.2 APE8-dihe-in -80.59, 66.97 APE8-rot-na 24.88 APE67-dihe-in -76.95, -9.87 -55.9, -29.5 APE12-dist-na 12.646 APE11-dist-na 8.596 APE10-dist-na 6.456 APE9-dist-in 7.111 None None MHO1142 XRAY 2.3 0.2 0.236 A 301 289 11 0 0 0 [[999, 1268]] 1.0 3d94 Homo sapiens TYR_IGF1R_HUMAN TYR 3.2e-95 324.3 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 8PYIAAA P08069 986 1286 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.183 12.51 None -115.76, -140.08 -56.69, 128.49 -118.25, -19.27 59.93, 80.29 -40.9, -38.76 out-out out 10.581 Saltbr-out 8.136 HRD-in -71.36, -56.99 87.46, -13.56 out-out-none SNCoon out-none ActLoopNT-out 8.922 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 111.18 APE9-dihe-in -126.65, 126.64 APE8-dihe-in -81.12, 76.62 APE8-rot-na 35.9 APE67-dihe-in -71.26, -20.53 -54.98, -37.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.172 APE9-dist-in 7.073 None None None XRAY 3.06 0.193 0.235 AAA 321 288 13 0 0 5 [[999, 1268]] 1.0 8pyi Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 8PYIBBB P08069 986 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.22 12.447 None -115.29, -140.05 -57.59, 130.35 -119.47, -19.04 57.6, 81.65 -39.33, -40.51 out-out out 10.581 Saltbr-out 8.138 HRD-in -71.54, -57.15 87.92, -15.23 out-out-none SNCoon out-none ActLoopNT-out 8.993 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 112.31 APE9-dihe-in -126.67, 128.52 APE8-dihe-in -80.09, 76.32 APE8-rot-na 35.62 APE67-dihe-in -70.72, -20.09 -56.2, -36.65 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.11 APE9-dist-in 7.068 None None None XRAY 3.06 0.193 0.235 BBB 321 287 13 0 0 5 [[999, 1268]] 1.0 8pyi Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 8PYICCC P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.166 12.505 None -114.85, -140.89 -57.29, 129.65 -118.38, -19.22 58.71, 80.33 -40.35, -39.19 out-out out 10.547 Saltbr-out 8.078 HRD-in -70.97, -56.86 87.86, -15.93 out-out-in SNCooi out-in ActLoopNT-out 8.949 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -146.69, 116.05 APE9-dihe-in -129.59, 126.27 APE8-dihe-in -80.63, 76.08 APE8-rot-na 36.39 APE67-dihe-in -71.13, -19.68 -54.93, -37.06 APE12-dist-na 999.0 APE11-dist-na 9.653 APE10-dist-na 6.184 APE9-dist-in 7.131 None None None XRAY 3.06 0.193 0.235 CCC 321 286 13 0 0 5 [[999, 1268]] 1.0 8pyi Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 8PYIDDD P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.219 12.459 None -115.04, -139.19 -57.22, 129.11 -118.66, -19.63 58.67, 81.12 -40.31, -39.48 out-out out 10.605 Saltbr-out 8.095 HRD-in -71.24, -57.12 86.84, -13.26 out-out-in SNCooi out-in ActLoopNT-out 8.935 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -91.29, 122.24 APE9-dihe-in -125.14, 125.87 APE8-dihe-in -79.9, 75.59 APE8-rot-na 36.0 APE67-dihe-in -70.95, -19.69 -56.73, -36.41 APE12-dist-na 999.0 APE11-dist-na 9.553 APE10-dist-na 5.986 APE9-dist-in 7.125 None None None XRAY 3.06 0.193 0.235 DDD 321 287 12 0 0 4 [[999, 1268]] 1.0 8pyi Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 8PYIEEE P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.27 12.44 None -115.61, -138.87 -56.86, 128.87 -118.49, -19.41 58.83, 81.0 -40.15, -38.87 out-out out 10.516 Saltbr-out 8.092 HRD-in -71.39, -56.94 87.82, -14.48 out-out-none SNCoon out-none ActLoopNT-out 8.951 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 116.42 APE9-dihe-in -125.67, 127.35 APE8-dihe-in -81.15, 76.83 APE8-rot-na 35.52 APE67-dihe-in -70.81, -19.39 -56.95, -36.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.155 APE9-dist-in 7.113 None None None XRAY 3.06 0.193 0.235 EEE 321 285 14 0 0 6 [[999, 1268]] 1.0 8pyi Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 8PYIFFF P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.31 12.506 None -114.84, -139.12 -57.32, 129.09 -119.24, -19.1 58.43, 80.95 -39.6, -40.34 out-out out 10.562 Saltbr-out 8.089 HRD-in -71.51, -57.69 87.61, -14.16 out-out-in SNCooi out-in ActLoopNT-out 8.913 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -146.97, 119.39 APE9-dihe-in -127.92, 126.81 APE8-dihe-in -81.17, 76.54 APE8-rot-na 34.85 APE67-dihe-in -70.74, -20.02 -56.2, -36.99 APE12-dist-na 14.267 APE11-dist-na 9.704 APE10-dist-na 6.176 APE9-dist-in 7.071 None None None XRAY 3.06 0.193 0.235 FFF 321 287 12 0 0 3 [[999, 1268]] 1.0 8pyi Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 8PYIGGG P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.215 12.411 None -115.39, -138.9 -56.85, 128.81 -118.89, -19.11 58.65, 81.01 -40.57, -39.34 out-out out 10.582 Saltbr-out 8.151 HRD-in -71.45, -56.87 87.79, -13.89 out-out-none SNCoon out-none ActLoopNT-out 8.956 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 115.56 APE9-dihe-in -139.88, 129.5 APE8-dihe-in -81.92, 78.52 APE8-rot-na 36.73 APE67-dihe-in -71.48, -19.02 -54.63, -36.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.313 APE9-dist-in 6.925 None None None XRAY 3.06 0.193 0.235 GGG 321 284 15 0 0 6 [[999, 1268]] 1.0 8pyi Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 8PYIHHH P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.201 12.494 None -116.04, -140.1 -57.52, 129.83 -118.81, -19.1 57.82, 80.84 -40.32, -39.43 out-out out 10.616 Saltbr-out 8.121 HRD-in -71.69, -57.04 87.53, -14.25 out-out-none SNCoon out-none ActLoopNT-out 8.959 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 112.91 APE9-dihe-in -126.66, 127.03 APE8-dihe-in -79.81, 75.92 APE8-rot-na 35.31 APE67-dihe-in -70.25, -19.75 -57.25, -36.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.154 APE9-dist-in 7.165 None None None XRAY 3.06 0.193 0.235 HHH 321 285 14 0 0 5 [[999, 1268]] 1.0 8pyi Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 5HZNA P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.523 11.883 None -122.71, -134.04 -48.48, 117.08 -112.65, 5.39 56.52, 89.56 -80.2, -12.63 out-out out 10.105 Saltbr-out 7.07 HRD-in -68.72, -44.68 74.42, -15.27 out-out-in SNCooi out-in ActLoopNT-out 9.082 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.2, 129.26 APE9-dihe-in -125.1, 113.12 APE8-dihe-in -76.3, 72.6 APE8-rot-na 31.29 APE67-dihe-in -71.82, -14.27 -59.77, -33.09 APE12-dist-na 12.78 APE11-dist-na 9.341 APE10-dist-na 6.003 APE9-dist-in 7.412 E1097A,E1099A None None XRAY 2.2 0.195 0.218 A 304 296 8 0 0 0 [[999, 1268]] 1.0 5hzn Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 5HZNB P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.668 11.698 None -120.23, -145.7 -34.99, 114.07 -109.86, 7.02 53.42, 94.67 -86.81, -17.85 out-out out 10.23 Saltbr-out 7.469 HRD-in -74.79, -42.86 77.21, -19.92 out-out-in SNCooi out-in ActLoopNT-out 8.972 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.8, 127.36 APE9-dihe-in -126.61, 120.91 APE8-dihe-in -82.51, 72.5 APE8-rot-na 31.18 APE67-dihe-in -70.34, -12.61 -56.19, -36.04 APE12-dist-na 12.71 APE11-dist-na 9.436 APE10-dist-na 6.009 APE9-dist-in 7.413 E1097A,E1099A None None XRAY 2.2 0.195 0.218 B 304 296 8 0 0 0 [[999, 1268]] 1.0 5hzn Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 5HZNC P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.504 11.893 None -117.5, -144.25 -35.28, 118.67 -116.54, 5.75 57.58, 87.45 -83.77, -13.7 out-out out 10.205 Saltbr-out 6.568 HRD-in -68.11, -52.05 81.72, -11.87 out-out-in SNCooi out-in ActLoopNT-out 8.979 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.64, 128.06 APE9-dihe-in -121.48, 117.98 APE8-dihe-in -78.81, 67.18 APE8-rot-na 28.39 APE67-dihe-in -73.45, -14.3 -52.08, -33.81 APE12-dist-na 13.032 APE11-dist-na 9.428 APE10-dist-na 6.062 APE9-dist-in 7.275 E1097A,E1099A None None XRAY 2.2 0.195 0.218 C 304 296 8 0 0 0 [[999, 1268]] 1.0 5hzn Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 5HZND P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.586 11.812 None -120.23, -138.34 -41.88, 115.18 -111.54, 6.87 52.55, 90.98 -80.5, -21.29 out-out out 10.156 Saltbr-out 7.057 HRD-in -75.17, -45.42 77.74, -21.01 out-out-in SNCooi out-in ActLoopNT-out 9.098 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.35, 128.86 APE9-dihe-in -120.46, 118.5 APE8-dihe-in -79.97, 71.37 APE8-rot-na 32.37 APE67-dihe-in -73.39, -13.02 -52.14, -35.35 APE12-dist-na 13.179 APE11-dist-na 9.253 APE10-dist-na 6.021 APE9-dist-in 7.453 E1097A,E1099A None None XRAY 2.2 0.195 0.218 D 304 304 0 0 0 0 [[999, 1268]] 1.0 5hzn Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 5HZNE P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.534 11.884 None -122.97, -133.9 -50.03, 120.11 -115.89, 7.06 56.85, 84.61 -81.92, -13.97 out-out out 10.09 Saltbr-out 7.001 HRD-in -71.62, -46.82 77.23, -15.08 out-out-in SNCooi out-in ActLoopNT-out 9.076 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.35, 128.61 APE9-dihe-in -123.88, 113.86 APE8-dihe-in -76.92, 69.0 APE8-rot-na 31.9 APE67-dihe-in -73.44, -14.93 -54.7, -32.97 APE12-dist-na 12.756 APE11-dist-na 9.32 APE10-dist-na 6.009 APE9-dist-in 7.417 E1097A,E1099A None None XRAY 2.2 0.195 0.218 E 304 296 8 0 0 0 [[999, 1268]] 1.0 5hzn Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 5HZNF P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.669 11.686 None -119.91, -143.87 -36.57, 117.22 -111.83, 7.84 53.92, 93.37 -86.48, -19.66 out-out out 10.245 Saltbr-out 7.495 HRD-in -71.54, -45.74 77.92, -19.28 out-out-in SNCooi out-in ActLoopNT-out 8.972 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.77, 125.58 APE9-dihe-in -123.67, 120.15 APE8-dihe-in -81.16, 71.31 APE8-rot-na 31.34 APE67-dihe-in -70.78, -14.02 -54.99, -34.82 APE12-dist-na 12.696 APE11-dist-na 9.431 APE10-dist-na 6.025 APE9-dist-in 7.415 E1097A,E1099A None None XRAY 2.2 0.195 0.218 F 304 296 8 0 0 0 [[999, 1268]] 1.0 5hzn Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 5HZNG P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.495 11.888 None -115.22, -143.92 -37.17, 121.14 -119.03, 5.44 57.57, 87.05 -84.31, -13.87 out-out out 10.212 Saltbr-out 6.568 HRD-in -69.56, -54.08 84.44, -12.44 out-out-in SNCooi out-in ActLoopNT-out 8.999 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.44, 128.11 APE9-dihe-in -122.01, 115.9 APE8-dihe-in -78.8, 69.19 APE8-rot-na 29.58 APE67-dihe-in -71.28, -16.87 -55.78, -34.47 APE12-dist-na 13.018 APE11-dist-na 9.418 APE10-dist-na 6.068 APE9-dist-in 7.312 E1097A,E1099A None None XRAY 2.2 0.195 0.218 G 304 296 8 0 0 0 [[999, 1268]] 1.0 5hzn Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 5HZNH P08069 983 1285 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.564 11.84 None -117.51, -139.77 -40.96, 115.52 -113.35, 4.84 52.59, 91.03 -79.05, -20.18 out-out out 10.169 Saltbr-out 7.132 HRD-in -75.23, -47.04 79.69, -19.55 out-out-in SNCooi out-in ActLoopNT-out 9.113 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.78, 128.57 APE9-dihe-in -119.04, 118.91 APE8-dihe-in -80.75, 73.24 APE8-rot-na 32.94 APE67-dihe-in -74.0, -12.28 -56.22, -33.69 APE12-dist-na 13.184 APE11-dist-na 9.261 APE10-dist-na 6.031 APE9-dist-in 7.449 E1097A,E1099A None None XRAY 2.2 0.195 0.218 H 304 303 0 0 0 0 [[999, 1268]] 1.0 5hzn Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 1M7NA P08069 982 1286 1367.0 No_ligand No_ligand Inactive DFGinter 8.164 7.514 None -63.65, 150.56 -83.71, 161.97 -57.58, 152.8 77.55, 99.86 65.02, 30.98 in-out in 9.867 Saltbr-out 8.828 HRD-in -83.45, -42.46 69.8, -16.63 out-out-in SNCooi out-in ActLoopNT-out 17.622 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.63, 113.99 APE9-dihe-in -128.05, 145.23 APE8-dihe-in -84.3, 65.47 APE8-rot-na 35.92 APE67-dihe-in -74.19, -1.69 -49.75, -32.81 APE12-dist-na 23.243 APE11-dist-na 19.123 APE10-dist-na 15.076 APE9-dist-in 7.467 None None None XRAY 2.7 0.229 0.294 A 322 299 6 0 0 0 [[999, 1268]] 1.0 1m7n Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 1M7NB P08069 982 1286 1367.0 No_ligand No_ligand Inactive DFGinter 9.13 7.337 None -73.47, 167.84 -87.9, 168.41 -62.8, 156.56 81.22, 124.1 55.25, 47.18 in-out in 9.829 Saltbr-out 8.107 HRD-in -100.99, -42.57 66.39, -13.05 out-out-in SNCooi out-in ActLoopNT-out 17.68 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -84.27, 123.84 APE9-dihe-in -122.55, 149.6 APE8-dihe-in -77.03, 59.62 APE8-rot-na 36.33 APE67-dihe-in -67.03, 6.96 -40.27, -45.78 APE12-dist-na 22.981 APE11-dist-na 18.942 APE10-dist-na 15.815 APE9-dist-in 7.184 None None None XRAY 2.7 0.229 0.294 B 322 299 6 0 0 0 [[999, 1268]] 1.0 1m7n Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 1P4OA P08069 978 1285 1367.0 No_ligand No_ligand Inactive DFGinter 8.937 7.453 None -75.61, 161.81 -88.19, 167.58 -62.75, 158.69 79.74, 92.2 58.69, 28.18 in-out in 9.669 Saltbr-out 8.161 HRD-in -85.36, -54.81 81.1, -18.95 out-out-in SNCooi out-in ActLoopNT-out 17.814 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.47, 124.06 APE9-dihe-in -124.38, 139.88 APE8-dihe-in -82.49, 64.57 APE8-rot-na 36.92 APE67-dihe-in -73.19, -6.91 -50.14, -35.0 APE12-dist-na 22.275 APE11-dist-na 18.248 APE10-dist-na 14.541 APE9-dist-in 7.274 E1097A,E1099A None None XRAY 1.5 0.209 0.236 A 322 308 0 0 0 0 [[999, 1268]] 1.0 1p4o Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 1P4OB P08069 977 1290 1367.0 No_ligand No_ligand Inactive DFGinter 8.973 7.373 None -74.95, 163.69 -90.41, 168.58 -63.57, 158.6 80.11, 88.87 59.26, 26.84 in-out in 9.712 Saltbr-out 8.134 HRD-in -85.93, -55.48 81.68, -17.46 out-out-in SNCooi out-in ActLoopNT-out 17.871 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.53, 126.34 APE9-dihe-in -129.41, 143.63 APE8-dihe-in -82.98, 67.29 APE8-rot-na 36.94 APE67-dihe-in -73.89, -4.17 -52.36, -34.34 APE12-dist-na 22.458 APE11-dist-na 18.39 APE10-dist-na 14.695 APE9-dist-in 7.171 E1097A,E1099A None None XRAY 1.5 0.209 0.236 B 322 314 0 0 0 0 [[999, 1268]] 1.0 1p4o Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3LW0A P08069 983 1286 1367.0 CCX:1,CCX:1287 Type3,Allosteric Inactive DFGout 14.069 6.949 BBAminus 170.04, 149.43 -168.43, 165.06 -107.76, 13.31 308.93, 125.37 90.3, 111.78 in-out in 9.111 Saltbr-out 3.854 HRD-in -70.2, -51.48 79.95, -15.38 out-out-in SNCooi out-in ActLoopNT-out 18.456 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.1, 127.88 APE9-dihe-in -120.17, 130.79 APE8-dihe-in -79.59, 68.17 APE8-rot-na 29.74 APE67-dihe-in -72.92, -7.93 -60.62, -32.58 APE12-dist-na 999.0 APE11-dist-na 13.844 APE10-dist-na 9.448 APE9-dist-in 7.294 E1097A,E1099A None None XRAY 1.79 0.157 0.185 A 304 292 12 0 0 3 [[999, 1268]] 1.0 3lw0 Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3LW0B P08069 983 1286 1367.0 CCX:2,CCX:1287 Type3,Allosteric Inactive DFGout 14.11 6.973 BBAminus 170.42, 151.14 -165.86, 166.3 -107.53, 14.79 308.98, 126.2 88.83, 109.35 in-out in 9.031 Saltbr-out 3.852 HRD-in -73.16, -50.06 79.09, -12.99 out-out-in SNCooi out-in ActLoopNT-out 18.441 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.78, 129.68 APE9-dihe-in -120.1, 131.04 APE8-dihe-in -81.08, 67.52 APE8-rot-na 31.55 APE67-dihe-in -72.5, -8.7 -59.87, -33.5 APE12-dist-na 999.0 APE11-dist-na 13.717 APE10-dist-na 9.388 APE9-dist-in 7.263 E1097A,E1099A None None XRAY 1.79 0.157 0.185 B 304 292 12 0 0 3 [[999, 1268]] 1.0 3lw0 Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3LW0C P08069 983 1286 1367.0 CCX:3,CCX:1287 Type3,Allosteric Inactive DFGout 14.138 6.957 BBAminus 171.38, 152.6 -167.31, 165.1 -107.82, 15.64 311.4, 121.85 88.58, 109.58 in-out in 9.103 Saltbr-out 3.922 HRD-in -69.69, -49.88 78.11, -14.34 out-out-in SNCooi out-in ActLoopNT-out 18.417 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.78, 130.13 APE9-dihe-in -121.41, 130.52 APE8-dihe-in -80.7, 68.48 APE8-rot-na 32.26 APE67-dihe-in -71.62, -8.72 -57.24, -35.28 APE12-dist-na 999.0 APE11-dist-na 13.845 APE10-dist-na 9.51 APE9-dist-in 7.27 E1097A,E1099A None None XRAY 1.79 0.157 0.185 C 304 292 12 0 0 3 [[999, 1268]] 1.0 3lw0 Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3O23A P08069 991 1283 1367.0 MQY:1 Type2 Inactive DFGout 19.367 12.672 None -140.99, -145.13 -170.55, 100.68 -44.16, -46.08 195.05, 101.85 38.62, 39.08 out-out out 10.354 Saltbr-out 5.096 HRD-in -68.63, -53.32 81.21, -11.17 out-out-in SNCooi out-in ActLoopNT-out 20.713 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.0, 129.34 APE9-dihe-in -127.06, 143.41 APE8-dihe-in -83.13, 67.71 APE8-rot-na 38.63 APE67-dihe-in -77.97, -3.22 -49.97, -33.61 APE12-dist-na 20.677 APE11-dist-na 15.959 APE10-dist-na 12.623 APE9-dist-in 7.259 Y987F None None XRAY 2.1 0.238 0.278 A 305 293 0 0 0 0 [[999, 1268]] 1.0 3o23 Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 8PYJAAA P08069 986 1270 1367.0 IEA:1301 Type2 Inactive DFGout 17.424 8.106 None -138.01, -167.4 -155.94, 116.33 -112.01, 27.11 203.64, 158.04 64.23, -172.08 in-out in 9.678 Saltbr-out 4.607 HRD-in -63.06, -47.9 63.67, -0.73 out-out-in SNCooi out-in ActLoopNT-out 18.23 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.03, 143.8 APE9-dihe-in -132.6, 135.07 APE8-dihe-in -83.01, 61.81 APE8-rot-na 38.8 APE67-dihe-in -67.3, -20.56 -57.7, -32.48 APE12-dist-na 13.823 APE11-dist-na 9.661 APE10-dist-na 5.585 APE9-dist-in 7.528 None None None XRAY 2.702 0.204 0.302 AAA 321 277 8 0 0 0 [[999, 1268]] 1.0 8pyj Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 8PYKAAA P08069 986 1270 1367.0 IC2:1301 Type2 Inactive DFGout 17.851 9.57 None -133.25, -156.99 -163.59, 105.08 -98.92, 70.17 206.03, 163.97 22.38, -129.27 out-out out 10.195 Saltbr-out 6.356 HRD-in -65.91, -54.94 83.67, -11.11 out-out-in SNCooi out-in ActLoopNT-out 18.256 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.17, 123.86 APE9-dihe-in -113.37, 130.73 APE8-dihe-in -77.02, 69.17 APE8-rot-na 33.02 APE67-dihe-in -67.4, -8.74 -59.14, -35.38 APE12-dist-na 13.709 APE11-dist-na 10.074 APE10-dist-na 6.084 APE9-dist-in 7.185 None None None XRAY 2.23 0.201 0.253 AAA 321 274 11 0 0 0 [[999, 1268]] 1.0 8pyk Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 8PYLAAA P08069 986 1270 1367.0 IE0:1301 Type2 Inactive DFGout 17.49 8.802 None -135.7, -153.05 -170.07, 104.78 -81.37, -21.74 213.38, 146.3 99.88, -176.88 out-out out 10.258 Saltbr-out 5.022 HRD-in -75.5, -46.79 77.95, -4.93 out-out-in SNCooi out-in ActLoopNT-out 18.194 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -61.72, 135.11 APE9-dihe-in -129.69, 131.01 APE8-dihe-in -77.6, 68.98 APE8-rot-na 32.9 APE67-dihe-in -67.64, -16.63 -60.37, -36.74 APE12-dist-na 13.769 APE11-dist-na 9.55 APE10-dist-na 5.581 APE9-dist-in 7.367 None None None XRAY 2.93 0.191 0.249 AAA 321 277 8 0 0 0 [[999, 1268]] 1.0 8pyl Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 8PYMAAA P08069 984 1270 1367.0 IED:1301 Type2 Inactive DFGout 17.388 8.066 None -140.29, -174.19 -150.41, 118.32 -112.85, 8.25 208.87, 151.48 70.27, -164.18 out-out out 10.103 Saltbr-out 5.09 HRD-in -64.19, -38.83 54.72, 11.98 out-out-in SNCooi out-in ActLoopNT-out 18.319 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.12, 139.29 APE9-dihe-in -129.72, 131.76 APE8-dihe-in -83.92, 64.41 APE8-rot-na 36.05 APE67-dihe-in -67.04, -15.79 -60.07, -31.92 APE12-dist-na 13.836 APE11-dist-na 9.654 APE10-dist-na 5.565 APE9-dist-in 7.56 None None None XRAY 2.652 0.24 0.309 AAA 321 278 9 0 0 0 [[999, 1268]] 1.0 8pym Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 8PYNAAA P08069 986 1270 1367.0 ICV:1301 Type2 Inactive DFGout 17.067 8.118 None -134.94, -158.57 -167.15, 119.05 -107.66, 14.53 216.32, 140.82 63.73, -168.46 in-out in 9.719 Saltbr-out 3.706 HRD-in -74.35, -43.01 75.39, -14.56 out-out-in SNCooi out-in ActLoopNT-out 18.077 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.14, 139.88 APE9-dihe-in -133.35, 137.86 APE8-dihe-in -79.24, 67.55 APE8-rot-na 29.6 APE67-dihe-in -72.27, -10.13 -65.45, -29.73 APE12-dist-na 13.949 APE11-dist-na 9.733 APE10-dist-na 5.656 APE9-dist-in 7.462 None None None XRAY 1.71 0.17 0.209 AAA 321 275 10 0 0 0 [[999, 1268]] 1.0 8pyn Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3LW0D P08069 983 1286 1367.0 CCX:4,CCX:1287 Type3,Allosteric Inactive DFGout 14.05 6.878 None 167.75, 151.96 -167.74, 166.55 -109.76, 14.11 305.35, 128.19 89.26, 110.63 in-out in 9.224 Saltbr-out 4.213 HRD-in -71.95, -49.8 77.64, -11.7 out-out-in SNCooi out-in ActLoopNT-out 18.495 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.75, 129.65 APE9-dihe-in -120.75, 130.34 APE8-dihe-in -80.64, 68.25 APE8-rot-na 34.21 APE67-dihe-in -72.08, -8.31 -58.75, -34.0 APE12-dist-na 999.0 APE11-dist-na 13.809 APE10-dist-na 9.457 APE9-dist-in 7.25 E1097A,E1099A None None XRAY 1.79 0.157 0.185 D 304 292 12 0 0 3 [[999, 1268]] 1.0 3lw0 Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 2OJ9A P08069 984 1286 1367.0 BMI:60301 Type1 Inactive None 13.649 18.682 None -109.08, -162.39 -72.97, 149.83 -62.93, 130.5 151.52, 94.1 65.22, -124.89 in-out in 9.905 Saltbr-out 9.511 HRD-in -62.11, -52.47 78.05, -12.6 out-out-in SNCooi out-in ActLoopNT-out 15.423 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.78, 118.25 APE9-dihe-in -124.44, 146.6 APE8-dihe-in -87.28, 67.01 APE8-rot-na 31.6 APE67-dihe-in -78.37, -2.27 -50.93, -32.32 APE12-dist-na 19.952 APE11-dist-na 15.233 APE10-dist-na 11.582 APE9-dist-in 7.287 None None None XRAY 2.0 0.217 0.276 A 307 295 8 0 0 0 [[999, 1268]] 1.0 2oj9 Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
IGF1R_HUMAN 3LVPD P08069 986 1285 1367.0 PDR:4 Type1 None DFGin 6.306 14.427 BLAminus -106.91, 166.93 53.44, 123.0 -131.84, 26.68 301.24, 78.21 -46.25, -39.95 in-in in 9.275 Saltbr-in 3.129 HRD-in -65.98, -38.21 59.59, -1.0 in-in-none SNCiin in-none ActLoopNT-in 2.829 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 78.94 APE8-dihe-in -74.27, 72.81 APE8-rot-na 31.79 APE67-dihe-in -58.26, -9.17 -42.05, -56.15 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.259 None None None XRAY 3.0 0.226 0.279 D 336 282 18 0 0 3 [[999, 1268]] 1.0 3lvp Homo sapiens TYR_IGF1R_HUMAN TYR 2.6e-95 324.6 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor

TYR_IGF1R (Insulin-like growth factor 1 receptor)

Total number of chains: 0
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name