TYK2 (Non-receptor tyrosine-protein kinase TYK2)

TYK2 has two kinase domains in its sequence, labeled here as TYK2-1 and TYK2-2. Structures with both domains are given in the last table and labeled as TYK2-12.
Domain_1: TYK2-1 (Pseudokinase)
Group: TYR
Example Uniprot: TYK2_HUMAN
Domain boundary: 589 - 875

Total number of chains: 42
Spatial Dihedral Chains Representative
DFGin None 42 8S99A
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment

Database table as tsv
Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens TYK2_HUMAN 7AX4A 2.12 Inactive DFGin None in-none out-out NM7 Type1 579 - 868 None None 0
Homo sapiens TYK2_HUMAN 7AX4B 2.12 Inactive DFGin None in-none out-out NM7 Type1 579 - 868 None None 0
Homo sapiens TYK2_HUMAN 8S98A 1.87 Inactive DFGin None in-none out-out ZRU Type1 578 - 867 None None 0
Homo sapiens TYK2_HUMAN 8S98B 1.87 Inactive DFGin None in-none out-out ZRU Type1 578 - 867 None None 0
Homo sapiens TYK2_HUMAN 8S98C 1.87 Inactive DFGin None in-none out-out ZRU Type1 578 - 868 None None 0
Homo sapiens TYK2_HUMAN 8S99A 1.71 Inactive DFGin None in-none out-out ZS3 Type1 578 - 868 None None 0
Homo sapiens TYK2_HUMAN 8S99B 1.71 Inactive DFGin None in-none out-out ZS3 Type1 579 - 867 None None 0
Homo sapiens TYK2_HUMAN 8S99C 1.71 Inactive DFGin None in-none out-out ZS3 Type1 578 - 867 None None 0
Homo sapiens TYK2_HUMAN 8S9AA 1.83 Inactive DFGin None in-none out-out ZSB Type1 577 - 868 None None 0
Homo sapiens TYK2_HUMAN 8S9AB 1.83 Inactive DFGin None in-none out-out ZSB Type1 578 - 867 None None 0
Homo sapiens TYK2_HUMAN 8S9AC 1.83 Inactive DFGin None in-none out-out ZSB Type1 578 - 867 None None 0
Homo sapiens TYK2_HUMAN 5TKDA 1.92 Inactive DFGin None in-none out-out 7GL Type1 581 - 866 None None 0
Homo sapiens TYK2_HUMAN 5TKDB 1.92 Inactive DFGin None in-none out-out 7GL Type1 581 - 867 None None 0
Homo sapiens TYK2_HUMAN 3ZONA 2.15 Inactive DFGin None in-none out-out IK1 Type1 577 - 870 None None 0
Homo sapiens TYK2_HUMAN 6NZRA 2.56 Inactive DFGin None in-none out-out LAJ Type1 578 - 867 None None 0
Homo sapiens TYK2_HUMAN 6NZRB 2.56 Inactive DFGin None in-none out-out LAJ Type1 580 - 868 None None 0
Homo sapiens TYK2_HUMAN 4WOVA 1.8 Inactive DFGin None in-none out-out 3SM Type1 580 - 869 None None 0
Homo sapiens TYK2_HUMAN 4WOVB 1.8 Inactive DFGin None in-none out-out 3SM Type1 580 - 867 None None 0
Homo sapiens TYK2_HUMAN 6NSLA 2.15 Inactive DFGin None in-none out-out KZJ Type1 581 - 866 None None 0
Homo sapiens TYK2_HUMAN 6NSLB 2.15 Inactive DFGin None in-none out-out KZJ Type1 581 - 867 None None 0
Homo sapiens TYK2_HUMAN 6NZEA 1.96 Inactive DFGin None in-none out-out L8Y Type1 581 - 863 None None 0
Homo sapiens TYK2_HUMAN 6NZEB 1.96 Inactive DFGin None in-none out-out L8Y Type1 580 - 867 None None 0
Homo sapiens TYK2_HUMAN 6NZFA 2.39 Inactive DFGin None in-none out-out L91 Type1 580 - 865 None None 0
Homo sapiens TYK2_HUMAN 6NZFB 2.39 Inactive DFGin None in-none out-out L91 Type1 580 - 867 None None 0
Homo sapiens TYK2_HUMAN 6NZHA 2.73 Inactive DFGin None in-none out-out L9A Type1 581 - 866 None None 0
Homo sapiens TYK2_HUMAN 6NZHB 2.73 Inactive DFGin None in-none out-out L9A Type1 580 - 867 None None 0
Homo sapiens TYK2_HUMAN 6NZPA 2.35 Inactive DFGin None in-none out-out LB7 Type1 580 - 869 None None 0
Homo sapiens TYK2_HUMAN 6NZPB 2.35 Inactive DFGin None in-none out-out LB7 Type1 580 - 868 None None 0
Homo sapiens TYK2_HUMAN 6NZQA 2.11 Inactive DFGin None in-none out-out LB4 Type1 580 - 867 None None 0
Homo sapiens TYK2_HUMAN 6NZQB 2.11 Inactive DFGin None in-none out-out LB4 Type1 580 - 868 None None 0
Homo sapiens TYK2_HUMAN 7K7OA 2.82 Inactive DFGin None in-none out-out VZJ Type1 580 - 867 None None 0
Homo sapiens TYK2_HUMAN 7K7OB 2.82 Inactive DFGin None in-none out-out VZJ Type1 580 - 868 None None 0
Homo sapiens TYK2_HUMAN 7K7QA 2.27 Inactive DFGin None in-none out-out VZG Type1 580 - 867 None None 0
Homo sapiens TYK2_HUMAN 7K7QB 2.27 Inactive DFGin None in-none out-out VZG Type1 580 - 868 None None 0
Homo sapiens TYK2_HUMAN 8TB5A 2.32 Inactive DFGin None in-none out-out ZOQ Type1 580 - 868 None None 0
Homo sapiens TYK2_HUMAN 8TB5B 2.32 Inactive DFGin None in-none out-out ZOQ Type1 580 - 868 None None 0
Homo sapiens TYK2_HUMAN 8TB6A 1.96 Inactive DFGin None in-none out-out ZOI Type1 572 - 869 None None 0
Homo sapiens TYK2_HUMAN 8TB6B 1.96 Inactive DFGin None in-none out-out ZOI Type1 580 - 867 None None 0
Homo sapiens TYK2_HUMAN 5C01A 2.15 Inactive DFGin None in-none out-out UNL Type1 580 - 868 None None 0
Homo sapiens TYK2_HUMAN 5C01B 2.15 Inactive DFGin None in-none out-out UNL Type1 579 - 869 None None 0
Homo sapiens TYK2_HUMAN 5C03A 1.9 Inactive DFGin None in-none out-out AGS Type1 579 - 869 None None 0
Homo sapiens TYK2_HUMAN 5C03B 1.9 Inactive DFGin None in-none out-out AGS Type1 580 - 870 None None 0

TYK2 (Non-receptor tyrosine-protein kinase TYK2)

Domain_2: TYK2-2
Group: TYR
Example Uniprot: TYK2_HUMAN
Domain boundary: 897 - 1176

Total number of chains in: 32
Spatial Dihedral Chains Representative
DFGin BLAminus 14 AF-P29597-K2A
DFGin ABAminus 17 6DBKA
DFGin None 1 4GIIA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment

Database table as tsv
Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens TYK2_HUMAN 7UYRA 2.15 Inactive DFGin ABAminus in-out in-in OVI Type1 890 - 1177 None X1054,X1055 0
Homo sapiens TYK2_HUMAN 4PY1A 2.16 Inactive DFGin ABAminus in-in in-in 2YK Type1 889 - 1178 C936A,Q969A,E971A,K972A,A1016S,C1142A X1054 0
Homo sapiens TYK2_HUMAN 6DBKA 2.0 Inactive DFGin ABAminus in-in in-in G5D Type1 889 - 1178 C936A,Q969A,E971A,K972A,C1142A X1054 0
Homo sapiens TYK2_HUMAN 6DBMA 2.368 Inactive DFGin ABAminus in-in in-in G4J Type1 889 - 1178 C936A,Q969A,E971A,K972A,C1142A X1054 0
Homo sapiens TYK2_HUMAN 6VNSA 2.09 Inactive DFGin ABAminus in-in in-in R5D Type1 889 - 1178 C936A,Q969A,E971A,K972A,C1142A X1054 0
Homo sapiens TYK2_HUMAN 6VNVA 2.15 Inactive DFGin ABAminus in-in in-in R4Y Type1 889 - 1178 C936A,Q969A,E971A,K972A,C1142A X1054 0
Homo sapiens TYK2_HUMAN 6VNXA 2.18 Inactive DFGin ABAminus in-in in-in R4V Type1 889 - 1178 C936A,Q969A,E971A,K972A,C1142A X1054 0
Homo sapiens TYK2_HUMAN 6VNYA 2.3 Inactive DFGin ABAminus in-in in-in R4S Type1 889 - 1178 C936A,Q969A,E971A,K972A,C1142A X1054 0
Homo sapiens TYK2_HUMAN 6X8FA 2.15 Inactive DFGin ABAminus in-in in-in UWP Type1 889 - 1178 C936A,Q969A,E971A,K972A,A1016S,C1142A X1054 0
Homo sapiens TYK2_HUMAN 6X8FC 2.15 Inactive DFGin ABAminus in-in in-in UWP Type1 889 - 1178 C936A,Q969A,E971A,K972A,A1016S,C1142A X1054 0
Homo sapiens TYK2_HUMAN 6X8GA 2.21 Inactive DFGin ABAminus in-in in-in UWM Type1 889 - 1178 C936A,Q969A,E971A,K972A,A1016S,C1142A X1054 0
Homo sapiens TYK2_HUMAN 3LXNA 2.5 Inactive DFGin ABAminus in-in in-in MI1 Type1 888 - 1178 C936A,Q969A,E971A,K972A,C1142A X1054 0
Homo sapiens TYK2_HUMAN 4GJ2A 2.4 Inactive DFGin ABAminus in-in in-in 0XH Type1 890 - 1176 C936A,Q969A,E971A,K972A,D1023N,C1142A None 0
Homo sapiens TYK2_HUMAN 4GJ3A 2.5 Inactive DFGin ABAminus in-in in-in 0XP Type1 890 - 1176 C936A,Q969A,E971A,K972A,D1023N,C1142A None 0
Homo sapiens TYK2_HUMAN 5WALA 2.45 Inactive DFGin ABAminus in-in in-in 9ZS Type1 890 - 1176 C936A,Q969A,E971A,K972A,D1023N,C1142A None 0
Homo sapiens TYK2_HUMAN AF-P29597-K2A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 889 - 1179 None None 0
Homo sapiens TYK2_HUMAN 7UYSA 2.15 Active DFGin BLAminus in-in in-in OVC Type1 890 - 1177 None X1054,X1055 0
Homo sapiens TYK2_HUMAN 7UYTA 2.14 Active DFGin BLAminus in-in in-in OV5 Type1 890 - 1177 None X1054,X1055 0
Homo sapiens TYK2_HUMAN 7UYUA 2.05 Active DFGin BLAminus in-in in-in OV0 Type1 889 - 1177 None X1054,X1055 0
Homo sapiens TYK2_HUMAN 4GVJA 2.03 Active DFGin BLAminus in-in in-in ADP Type1 889 - 1176 C936A,Q969A,E971A,K972A,C1142A None 0
Homo sapiens TYK2_HUMAN 3LXPA 1.65 Active DFGin BLAminus in-in in-in IZA Type1 888 - 1178 C936A,Q969A,E971A,K972A,C1142A X1054 0
Homo sapiens TYK2_HUMAN 5F1ZA 2.65 Active DFGin BLAminus in-in in-in 5U3 Type1 886 - 1176 None None 0
Homo sapiens TYK2_HUMAN 5F20A 2.91 Active DFGin BLAminus in-in in-in 5U4 Type1 888 - 1176 None None 0
Homo sapiens TYK2_HUMAN 6OVAA 2.5 Active DFGin BLAminus in-in in-in N9G Type1 888 - 1175 None None 0
Homo sapiens TYK2_HUMAN 4GFOA 2.3 Inactive DFGin BLAminus in-out in-in 0X2 Type1 890 - 1176 D1023N None 0
Homo sapiens TYK2_HUMAN 3NZ0A 2.0 Active DFGin BLAminus in-in in-in IZA Type1 888 - 1176 D1023N None 0
Homo sapiens TYK2_HUMAN 6AAMA 1.98 None DFGin BLAminus in-in in-none 9T6 Type1 888 - 1178 C936A,Q969A,E971A,K972A,D1023N,I1114L,C1142A None 0
Homo sapiens TYK2_HUMAN 4GIHA 2.0 Active DFGin BLAminus in-in in-in 0X5 Type1 890 - 1176 C936A,Q969A,E971A,K972A,D1023N,C1142A None 0
Homo sapiens TYK2_HUMAN 3NYXA 2.5 Inactive DFGin BLAminus out-out in-in TZ1 Type1.5_Back 889 - 1176 D1023N None 0
Homo sapiens TYK2_HUMAN 4GIIA 2.31 Inactive DFGin None in-in in-in 0X6 Type1 890 - 1176 C936A,Q969A,E971A,K972A,D1023N,C1142A None 0
Mus musculus TYK2_MOUSE 4E20A 2.6 Inactive DFGin ABAminus in-in in-in 0MY Type1 885 - 1174 D1020A None 0
Mus musculus TYK2_MOUSE 4E1ZA 2.5 Inactive DFGin ABAminus in-in in-in 0MX Type1 884 - 1174 D1020A None 0

TYK2 (Non-receptor tyrosine-protein kinase TYK2)

Domain_12: TYK2-12 (Pseudokinase)
Group: TYR
Example Uniprot: TYK2_HUMAN
Domain boundary: 589 - 1176

Total number of chains in: 1. Analysis of 2nd kinase domain given in table below.
Spatial Dihedral Chains Representative
DFGin BLAminus 1 4OLIA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment

Database table as tsv
Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens TYK2_HUMAN 4OLIA 2.8 Active DFGin BLAminus in-in in-in 2TT 2TT Allosteric Type1 579 - 1177 D1023N None 0