7AX4

TYK2 (Non-receptor tyrosine-protein kinase TYK2)
Pseudokinase
Group: TYR
Uniprot: TYK2_HUMAN
Organism: Homo sapiens
Domain boundary: 589 - 875
Resolu: 2.12

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin None in-none out-out NM7 Type1 579 - 868 0
B Inactive DFGin None in-none out-out NM7 Type1 579 - 868 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
       584        594        604        614 
nlsqLSFHRV DQKEITQLSH LGQGTRTNVY EGRLRVegsg 
       624        634        644        654 
dpeegkmdde dplvpgrdrg qELRVVLKVL DPSHHDIALA 
       664        674        684        694 
FYETASLMSQ VSHTHLAFVH GVCVRGPENI MVTEYVEHGP 
       704        714        724        734 
LDVWLRRERG HVPMAWKMVV AQQLASALSY LENKNLVHGN 
       744        754        764        774 
VCGRNILLAR LGLAEGTSPF IKLSDPGVGL GALSREERVE 
       784        794        804        814 
RIPWLAPECL PgganSLSTA MDKWGFGATL LEICFDGEAP 
       824        834        844        854 
LQSRSPSEKE HFYQRQHRLP EPSCPQLATL TSQCLTYEPT 
       864 
QRPSFRTILR DLTRl
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: None