3LXN

TYK2 (Non-receptor tyrosine-protein kinase TYK2)
Group: TYR
Uniprot: TYK2_HUMAN
Organism: Homo sapiens
Domain boundary: 897 - 1176
Resolu: 2.5

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin ABAminus in-in in-in MI1 Type1 888 - 1178 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain A
         -          -        894        904 
mahhhhhhhh hhgalevlfq gpgDPTVFHK RYLKKIRDLG 
       914        924        934        944 
EGHFGKVSLY CYDPTNDGTG EMVAVKALKA DAGPQHRSGW 
       954        964        974        984 
KQEIDILRTL YHEHIIKYKG CCEDAGAASL QLVMEYVPLG 
       994       1004       1014       1024 
SLRDYLPRHS IGLAQLLLFA QQICEGMAYL HAQHYIHRDL 
      1034       1044       1054       1064 
AARNVLLDND RLVKIGDFGL AKAVPEGHEY YRVredGDSP 
      1074       1084       1094       1104 
VFWYAPECLK EYKFYYASDV WSFGVTLYEL LTHCDSSQSP 
      1114       1124       1134       1144 
PTKFLELIGI AQGQMTVLRL TELLERGERL PRPDKCPAEV 
      1154       1164       1174 
YHLMKNCWET EASFRPTFEN LIPILKTVHE KYQGqaps
Lower-case residues are disordered in structure.
Mutations: C936A,Q969A,E971A,K972A,C1142A
Phosphorylation: X1054