4GJ2

TYK2 (Non-receptor tyrosine-protein kinase TYK2)
Group: TYR
Uniprot: TYK2_HUMAN
Organism: Homo sapiens
Domain boundary: 897 - 1176
Resolu: 2.4

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin ABAminus in-in in-in 0XH Type1 890 - 1176 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain A
       891        901        911        921 
mgspasdpTV FHKRYLKKIR DLGEGHFGKV SLYCYDPTND 
       931        941        951        961 
GTGEMVAVKA LKADAGPQHR SGWKQEIDIL RTLYHEHIIK 
       971        981        991       1001 
YKGCCEDAGA ASLQLVMEYV PLGSLRDYLP RHSIGLAQLL 
      1011       1021       1031       1041 
LFAQQICEGM AYLHAQHYIH RNLAARNVLL DNDRLVKIGD 
      1051       1061       1071       1081 
FGLAKAVPEG HEYYRVREDG DSPVFWYAPE CLKEYKFYYA 
      1091       1101       1111       1121 
SDVWSFGVTL YELLTHCDSS QSPPTKFLEL IGIAQGQMTV 
      1131       1141       1151       1161 
LRLTELLERG ERLPRPDKCP AEVYHLMKNC WETEASFRPT 
      1171          - 
FENLIPILKT VHEKYRhhhh hh
Lower-case residues are disordered in structure.
Mutations: C936A,Q969A,E971A,K972A,D1023N,C1142A
Phosphorylation: None