4OLI

TYK2 (Non-receptor tyrosine-protein kinase TYK2)
Pseudokinase
Group: TYR
Uniprot: TYK2_HUMAN
Organism: Homo sapiens
Domain boundary: 589 - 1176
Resolu: 2.8

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Active DFGin BLAminus in-in in-in 2TT 2TT Allosteric Type1 579 - 1177 0
Representative sequence - Chain A
- - 572 582
msyyhhhhhh dydipttenl yfqgaraspr tlnlsqLSFH
592 602 612 622
RVDQKEITQL SHLGQGTRTN VYEGRLRVeg sgdpeegkmd
632 642 652 662
dedplvpgrd rgqELRVVLK VLDPSHHDIA LAFYETASLM
672 682 692 702
SQVSHTHLAF VHGVCVRGPE NIMVTEYVEH GPLDVWLRRE
712 722 732 742
RGHVPMAWKM VVAQQLASAL SYLENKNLVH GNVCGRNILL
752 762 772 782
ARLGLAEGTS PFIKLSDPGV GLGALSREER VERIPWLAPE
792 802 812 822
CLPGgansLS TAMDKWGFGA TLLEICFDGE APLQSRSPSE
832 842 852 862
KEHFYQRQHR LPEPSCPQLA TLTSQCLTYE PTQRPSFRTI
872 882 892 902
LRDLTRLQPh nladvltvnp dspasdPTVF HKRYLKKIRD
912 922 932 942
LGEGHFGKVS LYCYDPTNDG TGEMVAVKAL kadcgpqHRS
952 962 972 982
GWKQEIDILR TLYHEHIIKY KGCCEDQGEK SLQLVMEYVP
992 1002 1012 1022
LGSLRDYLPR HSIGLAQLLL FAQQICEGMA YLHSQHYIHR
1032 1042 1052 1062
NLAARNVLLD NDrlVKIGDF GLAKAVPEGH EYYRVREDGD
1072 1082 1092 1102
SPVFWYAPEC LKEYKFYYAS DVWSFGVTLY ELLTHCDSSQ
1112 1122 1132 1142
SPPTKFLELI GiaqgqMTVL RLTELLERGE RLPRPDKCPC
1152 1162 1172 1182
EVYHLMKNCW ETEASFRPTF ENLIPILKTV HEKYQgqaps

vfsvc
Lower-case residues are disordered in structure.
Mutations: D1023N
Phosphorylation: None