JAK1 (Tyrosine-protein kinase JAK1)

JAK1 has two kinase domains in its sequence, labeled here as JAK1-1 and JAK1-2. Structures with both domains are given in the last table and labeled as JAK1-12.
Domain_1: JAK1-1 (Pseudokinase)
Group: TYR
Example Uniprot: JAK1_HUMAN
Domain boundary: 583 - 855

Total number of chains: 4
Spatial Dihedral Chains Representative
DFGin None 4 4L00A
All chains
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All chains - renumbered by
Uniprot PDB Alignment

Database table as tsv
Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens JAK1_HUMAN 4L01A 1.9 Inactive DFGin None in-none out-out No_ligand No_ligand 565 - 850 V658F None 0
Homo sapiens JAK1_HUMAN 4L01B 1.9 Inactive DFGin None in-none out-out No_ligand No_ligand 565 - 849 V658F None 0
Homo sapiens JAK1_HUMAN 4L00A 1.8 Inactive DFGin None in-none out-out No_ligand No_ligand 564 - 850 None None 0
Homo sapiens JAK1_HUMAN 4L00B 1.8 Inactive DFGin None in-none out-out No_ligand No_ligand 565 - 850 None None 0

JAK1 (Tyrosine-protein kinase JAK1)

Domain_2: JAK1-2
Group: TYR
Example Uniprot: JAK1_HUMAN
Domain boundary: 875 - 1153

Total number of chains in: 79
Spatial Dihedral Chains Representative
DFGin BLAminus 4 AF-P23458-K2A
DFGin ABAminus 75 6N7AA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment

Database table as tsv
Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens JAK1_HUMAN 4E4LE 2.0 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 864 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 3EYGA 1.9 Inactive DFGin ABAminus in-in in-in MI1 Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 3EYHA 2.0 Inactive DFGin ABAminus in-in in-in IZA Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 5E1EB 2.3 Inactive DFGin ABAminus in-in in-in 5JG Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6AAHA 1.83 Inactive DFGin ABAminus in-in in-in 9T6 Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6AAHB 1.83 Inactive DFGin ABAminus in-in in-in 9T6 Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6TPEA 2.87 Inactive DFGin ABAminus in-in in-in NTW Type1 864 - 1153 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6TPEB 2.87 Inactive DFGin ABAminus in-in in-in NTW Type1 864 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6TPFA 2.31 Inactive DFGin ABAminus in-in in-in NTQ Type1 864 - 1153 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6TPFB 2.31 Inactive DFGin ABAminus in-in in-in NTQ Type1 865 - 1153 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6GGHA 1.7 Inactive DFGin ABAminus in-in in-in EYQ Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6GGHB 1.7 Inactive DFGin ABAminus in-in in-in EYQ Type1 863 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6ELRA 1.8 Inactive DFGin ABAminus in-in in-in BFK Type1 854 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6ELRB 1.8 Inactive DFGin ABAminus in-in in-in BFK Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6SM8B 1.85 Inactive DFGin ABAminus in-in in-in LKT Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6SMBA 2.04 Inactive DFGin ABAminus in-in in-in LKQ Type1 863 - 1153 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6SMBB 2.04 Inactive DFGin ABAminus in-in in-in LKQ Type1 863 - 1153 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 4E4LA 2.0 Inactive DFGin ABAminus in-in in-in 0NH Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 4E4LB 2.0 Inactive DFGin ABAminus in-in in-in 0NH Type1 864 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 4E4LD 2.0 Inactive DFGin ABAminus in-in in-in 0NH Type1 864 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 4E4NA 1.9 Inactive DFGin ABAminus in-in in-in 0NL Type1 854 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 4E4NB 1.9 Inactive DFGin ABAminus in-in in-in 0NL Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 4E5WA 1.86 Inactive DFGin ABAminus in-in in-in 0NT Type1 854 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 4E5WB 1.86 Inactive DFGin ABAminus in-in in-in 0NT Type1 865 - 1153 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 4EHZA 2.174 Inactive DFGin ABAminus in-in in-in JAK Type1 858 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 4EHZB 2.174 Inactive DFGin ABAminus in-in in-in JAK Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 4EHZC 2.174 Inactive DFGin ABAminus in-in in-in JAK Type1 866 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 4EHZD 2.174 Inactive DFGin ABAminus in-in in-in JAK Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 4EI4A 2.22 Inactive DFGin ABAminus in-in in-in 0Q2 Type1 854 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 4EI4B 2.22 Inactive DFGin ABAminus in-in in-in 0Q2 Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 4FK6A 2.2 Inactive DFGin ABAminus in-in in-in 0UJ Type1 863 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 4FK6B 2.2 Inactive DFGin ABAminus in-in in-in 0UJ Type1 864 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 4I5CA 2.1 Inactive DFGin ABAminus in-in in-in C5I Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 4I5CB 2.1 Inactive DFGin ABAminus in-in in-in C5I Type1 854 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 4IVBA 1.9 Inactive DFGin ABAminus in-in in-in 1J5 Type1 854 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 4IVBB 1.9 Inactive DFGin ABAminus in-in in-in 1J5 Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 4IVCA 2.35 Inactive DFGin ABAminus in-in in-in 1J6 Type1 854 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 4IVCB 2.35 Inactive DFGin ABAminus in-in in-in 1J6 Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 4IVDA 1.93 Inactive DFGin ABAminus in-in in-in 15T Type1 854 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 4IVDB 1.93 Inactive DFGin ABAminus in-in in-in 15T Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 4K6ZA 2.73 Inactive DFGin ABAminus in-in in-in 1Q3 Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 4K77A 2.4 Inactive DFGin ABAminus in-in in-in 1Q4 Type1 864 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 4K77B 2.4 Inactive DFGin ABAminus in-in in-in 1Q4 Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 5HX8A 2.2 Inactive DFGin ABAminus in-in in-in 66P Type1 855 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 5HX8B 2.2 Inactive DFGin ABAminus in-in in-in 66P Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 5WO4A 1.84 Inactive DFGin ABAminus in-in in-in B7V Type1 854 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 5WO4B 1.84 Inactive DFGin ABAminus in-in in-in B7V Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6HZUA 2.2 Inactive DFGin ABAminus in-in in-in GYQ Type1 854 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6HZUB 2.2 Inactive DFGin ABAminus in-in in-in GYQ Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6N77A 1.64 Inactive DFGin ABAminus in-in in-in KEJ Type1 866 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6N77B 1.64 Inactive DFGin ABAminus in-in in-in KEJ Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6N78A 1.83 Inactive DFGin ABAminus in-in in-in KEP Type1 866 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6N79A 2.27 Inactive DFGin ABAminus in-in in-in KES Type1 866 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6N7BA 1.81 Inactive DFGin ABAminus in-in in-in KEY Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6N7CA 1.69 Inactive DFGin ABAminus in-in in-in KF1 Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6N7CB 1.69 Inactive DFGin ABAminus in-in in-in KF1 Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6N7DA 1.78 Inactive DFGin ABAminus in-in in-in KF4 Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6RSBA 1.8 Inactive DFGin ABAminus in-in in-in KGZ Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6RSBB 1.8 Inactive DFGin ABAminus in-in in-in KGZ Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6RSCA 1.85 Inactive DFGin ABAminus in-in in-in KH5 Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6RSCB 1.85 Inactive DFGin ABAminus in-in in-in KH5 Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6RSDA 1.76 Inactive DFGin ABAminus in-in in-in KH8 Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6RSDB 1.76 Inactive DFGin ABAminus in-in in-in KH8 Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6RSEA 1.8 Inactive DFGin ABAminus in-in in-in KHH Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6RSEB 1.8 Inactive DFGin ABAminus in-in in-in KHH Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6RSHA 1.71 Inactive DFGin ABAminus in-in in-in KHE Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6RSHB 1.71 Inactive DFGin ABAminus in-in in-in KHE Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6SM8A 1.85 Inactive DFGin ABAminus in-in in-in LKT Type1 854 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6N7AA 1.33 Inactive DFGin ABAminus in-in in-in KEV Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6N7AB 1.33 Inactive DFGin ABAminus in-in in-in KEV Type1 854 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 5KHWA 2.47 Inactive DFGin ABAminus in-in in-in ADP Type1 867 - 1153 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 5KHXA 2.4 Inactive DFGin ABAminus in-in in-in 6TE Type1 867 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6BBUA 2.08 Inactive DFGin ABAminus in-in in-in D7D Type1 867 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6DBNA 2.48 Inactive DFGin ABAminus in-in in-in G4J Type1 867 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 6W8LA 2.11 Inactive DFGin ABAminus in-in in-in R4S Type1 867 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN AF-P23458-K2A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 867 - 1154 None None 0
Homo sapiens JAK1_HUMAN 6C7YA 2.499 Active DFGin BLAminus in-in in-in ADP Type1 869 - 1153 None X1035 0
Homo sapiens JAK1_HUMAN 5E1EA 2.3 Active DFGin BLAminus in-in in-in 5JG Type1 865 - 1154 None X1034,X1035 0
Homo sapiens JAK1_HUMAN 5KHWB 2.47 Active DFGin BLAminus in-in in-in ADP Type1 867 - 1153 None X1034,X1035 0

JAK1 (Tyrosine-protein kinase JAK1)

Domain_12: JAK1-12
Group: TYR
Example Uniprot: JAK1_MOUSE
Domain boundary: 582 - 1152

Total number of chains in: 4. Analysis of 2nd kinase domain given in table below.
Spatial Dihedral Chains Representative
DFGin None 2 7T6FA
None None 2 8EWYA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment

Database table as tsv
Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Mus musculus JAK1_MOUSE 7T6FA 3.6 Inactive DFGin None in-out in-in ADN ADP Allosteric Type1 32 - 1153 None None 0
Mus musculus JAK1_MOUSE 7T6FB 3.6 Inactive DFGin None in-out in-in ADN ADP Allosteric Type1 32 - 1153 None None 0
Mus musculus JAK1_MOUSE 8EWYA 5.5 Inactive None None in-none in-in ADN ADP Allosteric Type1 32 - 1153 V657F None 0
Mus musculus JAK1_MOUSE 8EWYB 5.5 Inactive None None in-none in-in ADN ADP Allosteric Type1 32 - 1153 V657F None 0