7T6F

JAK1 (Tyrosine-protein kinase JAK1)
Group: TYR
Uniprot: JAK1_MOUSE
Organism: Mus musculus
Domain boundary: 582 - 1152
Resolu: 3.6

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin None in-out in-in ADN ADP Allosteric Type1 32 - 1153 0
B Inactive DFGin None in-out in-in ADN ADP Allosteric Type1 32 - 1153 0
Representative sequence - Chain B
10 20 30 40
mqylnikedc namafcakmr sfkktevkqv vPEPGVEVTF
50 60 70 80
YLLDREPLRL GSGEYTAEEL CIRAAQECSI SPLCHNLFAL
90 100 110 120
YDESTKLWYA PNRIITVDDK TSLRLHYRMR FYFTNWHGTN
130 140 150 160
DNEQSVWRHS PKkqkngyek krvpEATPLL DASSLEYLFA
170 180 190 200
QGQYDLIKCL APIRDPKTEQ DGHDIENECL GMAVLAISHY
210 220 230 240
AMMKKMQLPE LPKDISYKRY IPETLNKSIR QRNLLTRMRI
250 260 268 280
NNVFKDFLKE FNNKTICDSS VSTHDLKVKY LATLETLTKH
290 300 310 320
YGAEIFETSM LLISSENELS RCHSNDSGNV LYEVMVTGNL
330 340 350 360
GIQWRQKPNv vpvekeknkl krkkleynkh kkddernklr
370 380 390 400
EEWNNFSYFP EITHIVIKES VVSINKQDNK NMELKLSSRE
410 420 430 440
EALSFVSLVD GYFRLTADAH HYLCTDVAPP LIVHNIQNGC
450 460 470 480
HGPICTEYAI NKLRQEGSEE GMYVLRWSCT DFDNILMTVT
490 500 510 520
cfeksevlgg qKQFKNFQIE VQKGRYSLHG SMDHFPSLRD
530 540 550 560
LMNHLKKQIL RTDNISFVLK RCCQPKPREI SNLLVATKKA
570 580 590 600
QEWQPVYSMS QLSFDRILKK DIIQGEHLGR GTRTHIYSGT
610 620 630 640
LLDYkdeegi aeEKKIKVIL KVLDPSHRDI SLAFFEAASM
650 660 670 680
MRQVSHKHIV YLYGVCFRDV ENIMVEEFVE GGPLDLFMHR
690 700 710 720
KSDALTTPWK FKVAKQLASA LSYLEDKDLV HGNVCTKNLL
730 740 750 760
LAREGIDSDI GPFIKLSDPG IPVSVLTRQE CIERIPWIAP
770 780 790 800
ECVEDSKNLS VAADKWSFGT TLWEICYNGE IPLKDKTLIE
810 820 830 840
KERFYESRCR PVTPSCKELA DLMTRCMNYD PNQRPFFRAI
850 860 870 880
MRDINKLEEQ NPDIVsekqp tTEVDPTHFE KRFLKRIRDL
890 900 910 920
GEGHFGKVEL CRYDPEGDNT GEQVAVKSLK PESGGNHIAD
930 940 950 960
LKKEIEILRN LYHENIVKYK GICMEDGGNG IKLIMEFLPS
970 980 990 1000
GSLKEYLPKN KNKINLKQQL KYAIQICKGM DYLGSRQYVH
1010 1020 1030 1040
RDLAARNVLV ESEHQVKIGD FGLTKAIETD KEYYTVKDDR
1050 1060 1070 1080
DSPVFWYAPE CLIQCKFYIA SDVWSFGVTL HELLTYCDSD
1090 1100 1110 1120
FSPMALFLkm igpthgqMTV TRLVNTLKEG KRLPCPPNCP
1130 1140 1150 -
DEVYQLMRKC WEFQPSNRTT FQNLIEGFEA LLKgsdrkaa
-
vshwqhhhhh hhh
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: None