6N7A

JAK1 (Tyrosine-protein kinase JAK1)
Group: TYR
Uniprot: JAK1_HUMAN
Organism: Homo sapiens
Domain boundary: 875 - 1153
Resolu: 1.33

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin ABAminus in-in in-in KEV Type1 865 - 1154 0
B Inactive DFGin ABAminus in-in in-in KEV Type1 854 - 1154 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
       860        870        880        890 
GSGDIVSEKK PATEVDPTHF EKRFLKRIRD LGEGHFGKVE 
       900        910        920        930 
LCRYDPEGDN TGEQVAVKSL KPesggnHIA DLKKEIEILR 
       940        950        960        970 
NLYHENIVKY KGICTedggn GIKLIMEFLP SGSLKEYLPK 
       980        990       1000       1010 
NKNKINLKQQ LKYAVQICKG MDYLGSRQYV HRDLAARNVL 
      1020       1030       1040       1050 
VESEHQVKIG DFGLTKAIET DKEYYTVKDD RDSPVFWYAP 
      1060       1070       1080       1090 
ECLMQSKFYI ASDVWSFGVT LHELLTYCDS DSSPMALFLK 
      1100       1110       1120       1130 
MIGPTHGQMT VTRLVNTLKE GKRLPCPPNC PDEVYQLMRK 
      1140       1150 
CWEFQPSNRT SFQNLIEGFE ALLK
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: X1034,X1035