Protein kinases in complex with ADN

Total number of genes: 9
Total number of chains: 19
Spatial Dihedral Chains Representative
DFGin BLAminus 12 5LVNA
DFGin ABAminus 3 5LW1B
DFGin BLBminus 1 2EVAA
DFGin None 2 4O0UA
DFGinter None 1 1MUOA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
AGC PDPK1 PDPK1_HUMAN 3-phosphoinositide-dependent protein kinase 1 5LVNA 1.379 Active DFGin BLAminus in-in in-in ADN Type1
CAMK AURKA AURKA_HUMAN Aurora kinase A 4O0SA 2.5 Inactive DFGin BLAminus out-out in-out ADN Type1
CAMK AURKA AURKA_HUMAN Aurora kinase A 4O0WA 2.6 Inactive DFGin None out-out in-out ADN Type1
CAMK AURKA AURKA_HUMAN Aurora kinase A 4O0UA 2.6 Inactive DFGin None out-out in-out ADN Type1
CAMK AURKA AURKA_HUMAN Aurora kinase A 1MUOA 2.9 Inactive DFGinter None out-out none-out ADN Type1
CAMK PIM1 PIM1_HUMAN Serine/threonine-protein kinase pim-1 1YI4A 2.4 Active DFGin BLAminus in-in in-in ADN Type1
CK1 CSNK1D KC1D_HUMAN Casein kinase I isoform delta 7P7FC 1.96 Active DFGin BLAminus in-in in-in ADN Type1
CK1 CSNK1D KC1D_HUMAN Casein kinase I isoform delta 7P7FD 1.96 Active DFGin BLAminus in-in in-in ADN Type1
CMGC CDK9 CDK9_HUMAN Cyclin-dependent kinase 9 4OGRA 3.0 Active DFGin BLAminus in-in in-in ADN Type1
CMGC CDK9 CDK9_HUMAN Cyclin-dependent kinase 9 4OGRE 3.0 Active DFGin BLAminus in-in in-in ADN Type1
CMGC CDK9 CDK9_HUMAN Cyclin-dependent kinase 9 4OGRI 3.0 Active DFGin BLAminus in-in in-in ADN Type1
CMGC MAPK8 MK08_HUMAN Mitogen-activated protein kinase 8 5LW1B 3.2 Inactive DFGin ABAminus out-out out-out ADN Type1
CMGC MAPK8 MK08_HUMAN Mitogen-activated protein kinase 8 5LW1E 3.2 Inactive DFGin ABAminus in-out out-out ADN Type1
CMGC MAPK8 MK08_HUMAN Mitogen-activated protein kinase 8 5LW1H 3.2 Inactive DFGin ABAminus out-out out-out ADN Type1
STE TNIK TNIK_HUMAN TRAF2 and NCK-interacting protein kinase 8WM0A 2.8 Active DFGin BLAminus in-in in-in ADN Type1
TKL MAP3K7 M3K7_HUMAN Mitogen-activated protein kinase kinase kinase 7 2EVAA 2.0 Inactive DFGin BLBminus in-in none-out ADN Type1
TYR RET RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret 6FEKA 2.3 None DFGin BLAminus in-none in-in ADN Type1
TYR RET RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret 4CKJA 1.65 Active DFGin BLAminus in-in in-in ADN Type1
TYR RET RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret 4CKIA 2.116 Active DFGin BLAminus in-in in-in ADN Type1

Protein kinases in complex with ADN

Total number of genes: 12
Total number of chains: 25
Spatial Dihedral Chains Representative
DFGin BLAminus 14 5LVNA
DFGin ABAminus 3 5LW1B
DFGin BLBminus 1 2EVAA
DFGin None 4 7T6FA
DFGinter None 1 1MUOA
None None 2 8EWYA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Homo sapiens AGC PDPK1 PDPK1_HUMAN 3-phosphoinositide-dependent protein kinase 1 5LVNA 1.379 Active DFGin BLAminus in-in in-in ADN Type1
Homo sapiens CAMK AURKA AURKA_HUMAN Aurora kinase A 4O0SA 2.5 Inactive DFGin BLAminus out-out in-out ADN Type1
Homo sapiens CAMK AURKA AURKA_HUMAN Aurora kinase A 4O0WA 2.6 Inactive DFGin None out-out in-out ADN Type1
Homo sapiens CAMK AURKA AURKA_HUMAN Aurora kinase A 4O0UA 2.6 Inactive DFGin None out-out in-out ADN Type1
Homo sapiens CAMK AURKA AURKA_HUMAN Aurora kinase A 1MUOA 2.9 Inactive DFGinter None out-out none-out ADN Type1
Homo sapiens CAMK PIM1 PIM1_HUMAN Serine/threonine-protein kinase pim-1 1YI4A 2.4 Active DFGin BLAminus in-in in-in ADN Type1
Homo sapiens CK1 CSNK1D KC1D_HUMAN Casein kinase I isoform delta 7P7FC 1.96 Active DFGin BLAminus in-in in-in ADN Type1
Homo sapiens CK1 CSNK1D KC1D_HUMAN Casein kinase I isoform delta 7P7FD 1.96 Active DFGin BLAminus in-in in-in ADN Type1
Homo sapiens CMGC CDK9 CDK9_HUMAN Cyclin-dependent kinase 9 4OGRA 3.0 Active DFGin BLAminus in-in in-in ADN Type1
Homo sapiens CMGC CDK9 CDK9_HUMAN Cyclin-dependent kinase 9 4OGRE 3.0 Active DFGin BLAminus in-in in-in ADN Type1
Homo sapiens CMGC CDK9 CDK9_HUMAN Cyclin-dependent kinase 9 4OGRI 3.0 Active DFGin BLAminus in-in in-in ADN Type1
Homo sapiens CMGC MAPK8 MK08_HUMAN Mitogen-activated protein kinase 8 5LW1B 3.2 Inactive DFGin ABAminus out-out out-out ADN Type1
Homo sapiens CMGC MAPK8 MK08_HUMAN Mitogen-activated protein kinase 8 5LW1E 3.2 Inactive DFGin ABAminus in-out out-out ADN Type1
Homo sapiens CMGC MAPK8 MK08_HUMAN Mitogen-activated protein kinase 8 5LW1H 3.2 Inactive DFGin ABAminus out-out out-out ADN Type1
Homo sapiens STE TNIK TNIK_HUMAN TRAF2 and NCK-interacting protein kinase 8WM0A 2.8 Active DFGin BLAminus in-in in-in ADN Type1
Homo sapiens TKL MAP3K7 M3K7_HUMAN Mitogen-activated protein kinase kinase kinase 7 2EVAA 2.0 Inactive DFGin BLBminus in-in none-out ADN Type1
Homo sapiens TYR RET RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret 6FEKA 2.3 None DFGin BLAminus in-none in-in ADN Type1
Homo sapiens TYR RET RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret 4CKJA 1.65 Active DFGin BLAminus in-in in-in ADN Type1
Homo sapiens TYR RET RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret 4CKIA 2.116 Active DFGin BLAminus in-in in-in ADN Type1
Mus musculus AGC PRKACA KAPCA_MOUSE cAMP-dependent protein kinase catalytic subunit alpha 1FMOE 2.2 Active DFGin BLAminus in-in in-in ADN Type1
Mus musculus TYR JAK1 JAK1_MOUSE Tyrosine-protein kinase JAK1 7T6FA 3.6 Inactive DFGin None in-out in-in ADN ADP Allosteric Type1
Mus musculus TYR JAK1 JAK1_MOUSE Tyrosine-protein kinase JAK1 7T6FB 3.6 Inactive DFGin None in-out in-in ADN ADP Allosteric Type1
Mus musculus TYR JAK1 JAK1_MOUSE Tyrosine-protein kinase JAK1 8EWYA 5.5 Inactive None None in-none in-in ADN ADP Allosteric Type1
Mus musculus TYR JAK1 JAK1_MOUSE Tyrosine-protein kinase JAK1 8EWYB 5.5 Inactive None None in-none in-in ADN ADP Allosteric Type1
Saccharomyces cerevisiae CMGC SKY1 SKY1_YEAST Serine/threonine-protein kinase SKY1 1Q97B 2.3 Active DFGin BLAminus in-in in-in ADN Type1

Protein kinases in complex with ADN

Total number of genes: 3
Total number of chains: 6
Spatial Dihedral Chains Representative
DFGin BLAminus 2 1FMOE
DFGin None 2 7T6FA
None None 2 8EWYA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Mus musculus AGC PRKACA KAPCA_MOUSE cAMP-dependent protein kinase catalytic subunit alpha 1FMOE 2.2 Active DFGin BLAminus in-in in-in ADN Type1
Mus musculus TYR JAK1 JAK1_MOUSE Tyrosine-protein kinase JAK1 7T6FA 3.6 Inactive DFGin None in-out in-in ADN ADP Allosteric Type1
Mus musculus TYR JAK1 JAK1_MOUSE Tyrosine-protein kinase JAK1 7T6FB 3.6 Inactive DFGin None in-out in-in ADN ADP Allosteric Type1
Mus musculus TYR JAK1 JAK1_MOUSE Tyrosine-protein kinase JAK1 8EWYA 5.5 Inactive None None in-none in-in ADN ADP Allosteric Type1
Mus musculus TYR JAK1 JAK1_MOUSE Tyrosine-protein kinase JAK1 8EWYB 5.5 Inactive None None in-none in-in ADN ADP Allosteric Type1
Saccharomyces cerevisiae CMGC SKY1 SKY1_YEAST Serine/threonine-protein kinase SKY1 1Q97B 2.3 Active DFGin BLAminus in-in in-in ADN Type1