5KHW

JAK1 (Tyrosine-protein kinase JAK1)
Group: TYR
Uniprot: JAK1_HUMAN
Organism: Homo sapiens
Domain boundary: 875 - 1153
Resolu: 2.47

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin ABAminus in-in in-in ADP Type1 867 - 1153 0
B Active DFGin BLAminus in-in in-in ADP Type1 867 - 1153 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
       848        858        868        878 
gsimrdinkl eeqnpdivse kkpatevdPT HFEKRFLKRI 
       888        898        908        918 
RDLGEGHFGK VELCRYDPEG DNTGEQVAVK SLKpesggnH 
       928        938        948        958 
IADLKKEIEI LRNLYHENIV KYKGICTEdg gNGIKLIMEF 
       968        978        988        998 
LPSGSLKEYL PKNKNKINLK QQLKYAVQIC KGMDYLGSRQ 
      1008       1018       1028       1038 
YVHRDLAARN VLVESEHQVK IGDFGLTKAI ETDKEYYTVK 
      1048       1058       1068       1078 
DDRDSPVFWY APECLMQSKF YIASDVWSFG VTLHELLTYC 
      1088       1098       1108       1118 
DSDSSPMALF LKMIGPTHGQ MTVTRLVNTL KEGKRLPCPP 
      1128       1138       1148 
NCPDEVYQLM RKCWEFQPSN RTSFQNLIEG FEALLk
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: X1034,X1035