Ligand: ADN

Total number of chains: 20
Active chains: 8
Total number of genes: 10
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 12 60.0% 5LVNA
DFGin ABAminus 4 20.0% 8SE4B
DFGin None 2 10.0% 4O0UA
DFGin BLBminus 1 5.0% 2EVAA
DFGinter None 1 5.0% 1MUOA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AGC PDPK1 PDPK1_HUMAN 5LVNA 1.379 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
AGC PRKCB KPCB_HUMAN 8SE4B 2.68 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 30 - 671 0 TPO500,TPO642,SEP661 None Protein kinase C beta type
CAMK AURKA AURKA_HUMAN 4O0SA 2.5 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iioo ADN Type1 126 - 391 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 4O0WA 2.6 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaioi APEdist_nioo ADN Type1 125 - 391 0 None H254Y Aurora kinase A
CAMK AURKA AURKA_HUMAN 4O0UA 2.6 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaioi APEdist_oooo ADN Type1 126 - 391 0 None H254R Aurora kinase A
CAMK AURKA AURKA_HUMAN 1MUOA 2.9 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaoii APEdist_nooo ADN Type1 128 - 388 0 None None Aurora kinase A
CAMK PIM1 PIM1_HUMAN 1YI4A 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 33 - 305 0 SEP261 None Serine/threonine-protein kinase pim-1
CK1 CSNK1D KC1D_HUMAN 7P7FC 1.96 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 4 - 294 0 TPO220 None Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7P7FD 1.96 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 4 - 294 0 TPO220 None Casein kinase I isoform delta
CMGC CDK9 CDK9_HUMAN 4OGRA 3.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 8 - 330 0 TPO186 None Cyclin-dependent kinase 9
CMGC CDK9 CDK9_HUMAN 4OGRE 3.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 8 - 330 0 TPO186 None Cyclin-dependent kinase 9
CMGC CDK9 CDK9_HUMAN 4OGRI 3.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 8 - 330 0 TPO186 None Cyclin-dependent kinase 9
CMGC MAPK8 MK08_HUMAN 5LW1B 3.2 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaoii APEdist_oooo ADN Type1 8 - 362 0 None None Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 5LW1E 3.2 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaoii APEdist_oooo ADN Type1 8 - 362 0 None None Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 5LW1H 3.2 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaoii APEdist_oooo ADN Type1 8 - 362 0 None None Mitogen-activated protein kinase 8
STE TNIK TNIK_HUMAN 8WM0A 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 12 - 310 0 TPO181,TPO187 None TRAF2 and NCK-interacting protein kinase
TKL MAP3K7 M3K7_HUMAN 2EVAA 2.0 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaiii APEdist_nnno ADN Type1 31 - 305 0 None None Mitogen-activated protein kinase kinase kinase 7
TYR RET RET_HUMAN 6FEKA 2.3 Inactive DFGin‑BLAminus in-none in-out TYR APEdihe_oiiai APEdist_aaai ADN Type1 705 - 1010 0 PTR900,PTR905 S904F Proto-oncogene tyrosine-protein kinase receptor Ret
TYR RET RET_HUMAN 4CKJA 1.65 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ADN Type1 705 - 1013 0 PTR905 None Proto-oncogene tyrosine-protein kinase receptor Ret
TYR RET RET_HUMAN 4CKIA 2.116 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ADN Type1 705 - 1013 0 PTR900,PTR905 M918T Proto-oncogene tyrosine-protein kinase receptor Ret

Ligand: ADN

Total number of chains: 28
Active chains: 12
Total number of genes: 14
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 16 57.1% 5LVNA
DFGin ABAminus 4 14.3% 8SE4B
DFGin None 4 14.3% 4O0UA
None None 2 7.1% 8EWYA
DFGin BLBminus 1 3.6% 2EVAA
DFGinter None 1 3.6% 1MUOA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC LIK M1UWB5_CYAM1 9FMPA 2.69 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 449 - 809 0 None None LAMMER-like dual specificity kinase Cyanidioschyzon merolae
CMGC LIK M1UWB5_CYAM1 9FMPB 2.69 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 451 - 808 0 TPO683 None LAMMER-like dual specificity kinase Cyanidioschyzon merolae
AGC PDPK1 PDPK1_HUMAN 5LVNA 1.379 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PRKCB KPCB_HUMAN 8SE4B 2.68 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 30 - 671 0 TPO500,TPO642,SEP661 None Protein kinase C beta type Homo sapiens
CAMK AURKA AURKA_HUMAN 4O0SA 2.5 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iioo ADN Type1 126 - 391 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 4O0WA 2.6 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaioi APEdist_nioo ADN Type1 125 - 391 0 None H254Y Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 4O0UA 2.6 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaioi APEdist_oooo ADN Type1 126 - 391 0 None H254R Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 1MUOA 2.9 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaoii APEdist_nooo ADN Type1 128 - 388 0 None None Aurora kinase A Homo sapiens
CAMK PIM1 PIM1_HUMAN 1YI4A 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 33 - 305 0 SEP261 None Serine/threonine-protein kinase pim-1 Homo sapiens
CK1 CSNK1D KC1D_HUMAN 7P7FC 1.96 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 4 - 294 0 TPO220 None Casein kinase I isoform delta Homo sapiens
CK1 CSNK1D KC1D_HUMAN 7P7FD 1.96 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 4 - 294 0 TPO220 None Casein kinase I isoform delta Homo sapiens
CMGC CDK9 CDK9_HUMAN 4OGRA 3.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 8 - 330 0 TPO186 None Cyclin-dependent kinase 9 Homo sapiens
CMGC CDK9 CDK9_HUMAN 4OGRE 3.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 8 - 330 0 TPO186 None Cyclin-dependent kinase 9 Homo sapiens
CMGC CDK9 CDK9_HUMAN 4OGRI 3.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 8 - 330 0 TPO186 None Cyclin-dependent kinase 9 Homo sapiens
CMGC MAPK8 MK08_HUMAN 5LW1B 3.2 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaoii APEdist_oooo ADN Type1 8 - 362 0 None None Mitogen-activated protein kinase 8 Homo sapiens
CMGC MAPK8 MK08_HUMAN 5LW1E 3.2 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaoii APEdist_oooo ADN Type1 8 - 362 0 None None Mitogen-activated protein kinase 8 Homo sapiens
CMGC MAPK8 MK08_HUMAN 5LW1H 3.2 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaoii APEdist_oooo ADN Type1 8 - 362 0 None None Mitogen-activated protein kinase 8 Homo sapiens
STE TNIK TNIK_HUMAN 8WM0A 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 12 - 310 0 TPO181,TPO187 None TRAF2 and NCK-interacting protein kinase Homo sapiens
TKL MAP3K7 M3K7_HUMAN 2EVAA 2.0 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaiii APEdist_nnno ADN Type1 31 - 305 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
TYR RET RET_HUMAN 6FEKA 2.3 Inactive DFGin‑BLAminus in-none in-out TYR APEdihe_oiiai APEdist_aaai ADN Type1 705 - 1010 0 PTR900,PTR905 S904F Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
TYR RET RET_HUMAN 4CKJA 1.65 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ADN Type1 705 - 1013 0 PTR905 None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
TYR RET RET_HUMAN 4CKIA 2.116 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ADN Type1 705 - 1013 0 PTR900,PTR905 M918T Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
AGC PRKACA KAPCA_MOUSE 1FMOE 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 14 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
TYR JAK1-12 JAK1_MOUSE 7T6FA 3.6 Inactive DFGin‑None in-out in-out TYR APEdihe_oiiai APEdist_aaai ADN, ADP Allosteric, ATPlike 32 - 1153 0 None None Tyrosine-protein kinase JAK1 Mus musculus
TYR JAK1-12 JAK1_MOUSE 7T6FB 3.6 Inactive DFGin‑None in-out in-out TYR APEdihe_oiiai APEdist_aaai ADN, ADP Allosteric, ATPlike 32 - 1153 0 None None Tyrosine-protein kinase JAK1 Mus musculus
TYR JAK1-12 JAK1_MOUSE 8EWYA 5.5 Inactive None‑None in-none in-in TYR APEdihe_iiiai APEdist_aaai ADN, ADP Allosteric, ATPlike 32 - 1153 0 None V657F Tyrosine-protein kinase JAK1 Mus musculus
TYR JAK1-12 JAK1_MOUSE 8EWYB 5.5 Inactive None‑None in-none in-in TYR APEdihe_iiiai APEdist_aaai ADN, ADP Allosteric, ATPlike 32 - 1153 0 None V657F Tyrosine-protein kinase JAK1 Mus musculus
CMGC SKY1 SKY1_YEAST 1Q97B 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 145 - 737 0 None None Serine/threonine-protein kinase SKY1 Saccharomyces cerevisiae

Ligand: ADN

Total number of chains: 8
Active chains: 4
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 50.0% 1FMOE
DFGin None 2 25.0% 7T6FA
None None 2 25.0% 8EWYA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC LIK M1UWB5_CYAM1 9FMPA 2.69 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 449 - 809 0 None None LAMMER-like dual specificity kinase Cyanidioschyzon merolae
CMGC LIK M1UWB5_CYAM1 9FMPB 2.69 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 451 - 808 0 TPO683 None LAMMER-like dual specificity kinase Cyanidioschyzon merolae
AGC PRKACA KAPCA_MOUSE 1FMOE 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 14 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
TYR JAK1-12 JAK1_MOUSE 7T6FA 3.6 Inactive DFGin‑None in-out in-out TYR APEdihe_oiiai APEdist_aaai ADN, ADP Allosteric, ATPlike 32 - 1153 0 None None Tyrosine-protein kinase JAK1 Mus musculus
TYR JAK1-12 JAK1_MOUSE 7T6FB 3.6 Inactive DFGin‑None in-out in-out TYR APEdihe_oiiai APEdist_aaai ADN, ADP Allosteric, ATPlike 32 - 1153 0 None None Tyrosine-protein kinase JAK1 Mus musculus
TYR JAK1-12 JAK1_MOUSE 8EWYA 5.5 Inactive None‑None in-none in-in TYR APEdihe_iiiai APEdist_aaai ADN, ADP Allosteric, ATPlike 32 - 1153 0 None V657F Tyrosine-protein kinase JAK1 Mus musculus
TYR JAK1-12 JAK1_MOUSE 8EWYB 5.5 Inactive None‑None in-none in-in TYR APEdihe_iiiai APEdist_aaai ADN, ADP Allosteric, ATPlike 32 - 1153 0 None V657F Tyrosine-protein kinase JAK1 Mus musculus
CMGC SKY1 SKY1_YEAST 1Q97B 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 145 - 737 0 None None Serine/threonine-protein kinase SKY1 Saccharomyces cerevisiae