TYR_RET (Proto-oncogene tyrosine-protein kinase receptor Ret)

Total number of chains: 38
Active chains: 2
Family: TYR
Uniprot: RET_HUMAN
Kinase Domain Residues: 724 - 1007
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 38 100.0% AF-P07949-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P07949-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 716 - 1015 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret
AF-P07949-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 716 - 1015 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret
2IVTA 2.6 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai AMP ATPlike 703 - 1012 0 PTR905 None Proto-oncogene tyrosine-protein kinase receptor Ret
6NE7A 1.99 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai AMP ATPlike 705 - 1013 0 PTR900,PTR905 G810A Proto-oncogene tyrosine-protein kinase receptor Ret
5AMNA 2.57 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai DTQ Type1 705 - 1010 0 PTR900,PTR905 None Proto-oncogene tyrosine-protein kinase receptor Ret
6FEKA 2.3 Inactive DFGin‑BLAminus in-none in-out TYR APEdihe_oiiai APEdist_aaai ADN Type1 705 - 1010 0 PTR900,PTR905 S904F Proto-oncogene tyrosine-protein kinase receptor Ret
6I82A 2.05 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai H6W Type1 705 - 1012 0 PTR928 V804M Proto-oncogene tyrosine-protein kinase receptor Ret
6I82B 2.05 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai H6W Type1 714 - 1012 0 PTR928 V804M Proto-oncogene tyrosine-protein kinase receptor Ret
6I83A 1.88 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai H72 Type1 705 - 1013 0 PTR905 V804M Proto-oncogene tyrosine-protein kinase receptor Ret
6VHGA 2.303 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai QX1 Type1 707 - 1012 0 PTR905,PTR928 None Proto-oncogene tyrosine-protein kinase receptor Ret
2IVSA 2.0 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACK Type1 713 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret
2IVSB 2.0 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACK Type1 703 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret
2IVUA 2.5 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ZD6 Type1 703 - 1012 0 PTR905 None Proto-oncogene tyrosine-protein kinase receptor Ret
2X2KA 2.6 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai X2K Type1 703 - 1013 0 PTR905 None Proto-oncogene tyrosine-protein kinase receptor Ret
2X2LA 2.0 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai X2L Type1 703 - 1010 0 PTR905 None Proto-oncogene tyrosine-protein kinase receptor Ret
2X2MA 2.5 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai X2M Type1 703 - 1013 0 PTR905 None Proto-oncogene tyrosine-protein kinase receptor Ret
2X2MB 2.5 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai X2M Type1 703 - 1011 0 PTR905 None Proto-oncogene tyrosine-protein kinase receptor Ret
4CKJA 1.65 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ADN Type1 705 - 1013 0 PTR905 None Proto-oncogene tyrosine-protein kinase receptor Ret
6NJAA 1.92 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ADE Type1 705 - 1013 0 PTR900,PTR905 None Proto-oncogene tyrosine-protein kinase receptor Ret
7DU9A 2.31 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai Q4J Type1 714 - 1011 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret
7DU9B 2.31 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai Q4J Type1 705 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret
7JU5A 1.9 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai Q4J Type1 705 - 1013 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret
7JU5B 1.9 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai Q4J Type1 710 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret
7JU6A 2.06 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai Q6G Type1 713 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret
7NZNA 2.39 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai VJH Type1 705 - 1013 0 PTR900,PTR905 None Proto-oncogene tyrosine-protein kinase receptor Ret
2IVVA 2.25 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai PP1 Type1 703 - 1011 0 PTR905 None Proto-oncogene tyrosine-protein kinase receptor Ret
5FM2A 3.3 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai PP1 Type1 710 - 1011 0 PTR809,PTR905,SEP909,PTR928 None Proto-oncogene tyrosine-protein kinase receptor Ret
5FM3A 2.95 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai PP1 Type1 707 - 1011 0 PTR809,PTR905,SEP909,PTR928 None Proto-oncogene tyrosine-protein kinase receptor Ret
4CKIA 2.116 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ADN Type1 705 - 1013 0 PTR900,PTR905 M918T Proto-oncogene tyrosine-protein kinase receptor Ret
6NECA 1.87 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai XIN Type1.5_Back 713 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret
6NECC 1.87 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai XIN Type1.5_Back 705 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret
7DUAA 1.64 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai HJ0 Type1.5_Back 712 - 1011 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret
7DUAB 1.64 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai HJ0 Type1.5_Back 705 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret
7RUNA 3.51 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 7QU Type1.5_Back 705 - 1012 0 PTR809,PTR905,SEP909,PTR928 None Proto-oncogene tyrosine-protein kinase receptor Ret
7RUNB 3.51 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 7QU Type1.5_Back 706 - 1012 0 PTR809,PTR905,SEP909,PTR928 None Proto-oncogene tyrosine-protein kinase receptor Ret
7DU8A 2.75 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai Q6G Type1.5_Front 714 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret
7DU8B 2.75 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai Q6G Type1.5_Front 705 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret
7JU6B 2.06 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai Q6G Type1.5_Front 705 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret

TYR_RET (Proto-oncogene tyrosine-protein kinase receptor Ret)

Total number of chains: 38
Active chains: 2
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 38 100.0% AF-P07949-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Advanced page

Hover over column headers for tooltip help

UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
RET_HUMAN AF-P07949-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 716 - 1015 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN AF-P07949-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 716 - 1015 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 2IVTA 2.6 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai AMP ATPlike 703 - 1012 0 PTR905 None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 6NE7A 1.99 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai AMP ATPlike 705 - 1013 0 PTR900,PTR905 G810A Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 5AMNA 2.57 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai DTQ Type1 705 - 1010 0 PTR900,PTR905 None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 6FEKA 2.3 Inactive DFGin‑BLAminus in-none in-out TYR APEdihe_oiiai APEdist_aaai ADN Type1 705 - 1010 0 PTR900,PTR905 S904F Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 6I82A 2.05 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai H6W Type1 705 - 1012 0 PTR928 V804M Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 6I82B 2.05 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai H6W Type1 714 - 1012 0 PTR928 V804M Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 6I83A 1.88 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai H72 Type1 705 - 1013 0 PTR905 V804M Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 6VHGA 2.303 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai QX1 Type1 707 - 1012 0 PTR905,PTR928 None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 2IVSA 2.0 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACK Type1 713 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 2IVSB 2.0 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ACK Type1 703 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 2IVUA 2.5 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ZD6 Type1 703 - 1012 0 PTR905 None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 2X2KA 2.6 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai X2K Type1 703 - 1013 0 PTR905 None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 2X2LA 2.0 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai X2L Type1 703 - 1010 0 PTR905 None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 2X2MA 2.5 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai X2M Type1 703 - 1013 0 PTR905 None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 2X2MB 2.5 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai X2M Type1 703 - 1011 0 PTR905 None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 4CKJA 1.65 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ADN Type1 705 - 1013 0 PTR905 None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 6NJAA 1.92 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ADE Type1 705 - 1013 0 PTR900,PTR905 None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 7DU9A 2.31 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai Q4J Type1 714 - 1011 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 7DU9B 2.31 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai Q4J Type1 705 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 7JU5A 1.9 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai Q4J Type1 705 - 1013 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 7JU5B 1.9 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai Q4J Type1 710 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 7JU6A 2.06 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai Q6G Type1 713 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 7NZNA 2.39 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai VJH Type1 705 - 1013 0 PTR900,PTR905 None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 2IVVA 2.25 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai PP1 Type1 703 - 1011 0 PTR905 None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 5FM2A 3.3 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai PP1 Type1 710 - 1011 0 PTR809,PTR905,SEP909,PTR928 None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 5FM3A 2.95 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai PP1 Type1 707 - 1011 0 PTR809,PTR905,SEP909,PTR928 None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 4CKIA 2.116 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ADN Type1 705 - 1013 0 PTR900,PTR905 M918T Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 6NECA 1.87 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai XIN Type1.5_Back 713 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 6NECC 1.87 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai XIN Type1.5_Back 705 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 7DUAA 1.64 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai HJ0 Type1.5_Back 712 - 1011 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 7DUAB 1.64 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai HJ0 Type1.5_Back 705 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 7RUNA 3.51 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 7QU Type1.5_Back 705 - 1012 0 PTR809,PTR905,SEP909,PTR928 None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 7RUNB 3.51 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 7QU Type1.5_Back 706 - 1012 0 PTR809,PTR905,SEP909,PTR928 None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 7DU8A 2.75 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai Q6G Type1.5_Front 714 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 7DU8B 2.75 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai Q6G Type1.5_Front 705 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
RET_HUMAN 7JU6B 2.06 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai Q6G Type1.5_Front 705 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens

TYR_RET (Proto-oncogene tyrosine-protein kinase receptor Ret)

Total number of chains: 0
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Advanced page

Hover over column headers for tooltip help

UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism