Ligand: ADN

Total number of chains: 20
Active chains: 8
Total number of genes: 10
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 12 60.0% 5LVNA
DFGin ABAminus 4 20.0% 8SE4B
DFGin None 2 10.0% 4O0UA
DFGin BLBminus 1 5.0% 2EVAA
DFGinter None 1 5.0% 1MUOA
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC PDPK1 PDPK1_HUMAN 5LVNA O15530 75 359 556.0 ADN:402 Type1 Active DFGin 6.493 14.784 BLAminus -138.56, -175.41 73.41, 75.09 -105.63, 5.44 285.54, 101.95 -63.79, -19.6 in-in in 8.435 Saltbr-in 2.739 HRD-in -74.59, -52.51 78.18, -12.02 in-in-in SNCiii in-in ActLoopNT-in 2.9 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.48, 161.66 APE9-dihe-na 136.02, -164.27 APE8-dihe-in -134.21, 135.25 APE8-rot-in 295.47 APE67-dihe-in -61.9, -23.15 -53.94, -45.84 APE12-dist-in 7.439 APE11-dist-in 10.533 APE10-dist-in 4.893 APE9-dist-in 3.566 Y288G,Q292A SEP241 SEP241 XRAY 1.379 0.135 0.162 A 311 285 0 0 0 0 [[82, 342]] 1.0 5lvn AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PRKCB KPCB_HUMAN 8SE4B P05771 30 671 671.0 ADN:701 Type1 Inactive DFGin 5.738 12.971 ABAminus -126.66, -34.17 -84.97, 112.43 -117.68, 39.4 296.69, 93.7 -74.7, -30.34 in-in in 8.26 Saltbr-in 2.51 HRD-in -88.0, -50.22 70.29, 1.81 in-in-in SNCiii in-in ActLoopNT-in 3.073 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.54, 164.05 APE9-dihe-na 118.34, -179.99 APE8-dihe-in -91.65, 129.4 APE8-rot-in 306.62 APE67-dihe-in -69.42, -21.97 -51.1, -33.02 APE12-dist-in 8.632 APE11-dist-in 11.783 APE10-dist-in 6.261 APE9-dist-in 3.776 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 2.68 0.206 0.258 B 672 589 0 0 0 0 [[342, 600]] 1.0 8se4 AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
CAMK AURKA AURKA_HUMAN 4O0SA O14965 126 391 403.0 ADN:500 Type1 Inactive DFGin 6.058 16.559 BLAminus -149.62, -178.05 57.82, 65.99 -83.76, 4.5 260.08, 87.32 -48.25, -52.63 out-out out 10.511 Saltbr-out 4.112 HRD-in -67.13, -53.86 77.45, -15.34 out-in-out SNCoio in-out ActLoopNT-in 2.945 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -80.39, -35.33 APE9-dihe-na -145.46, 176.17 APE8-dihe-in -59.32, 141.88 APE8-rot-out 196.74 APE67-dihe-in -51.21, -41.15 -95.86, -1.7 APE12-dist-in 12.477 APE11-dist-in 13.48 APE10-dist-out 10.732 APE9-dist-out 11.027 None None None XRAY 2.5 0.238 0.25 A 282 265 1 0 0 1 [[133, 383]] 1.0 4o0s CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4O0WA O14965 125 391 403.0 ADN:501 Type1 Inactive DFGin 6.272 16.598 None -99.25, -54.63 -80.04, -74.28 72.86, -1.54 279.35, 93.09 -53.76, -20.49 out-out out 11.319 Saltbr-out 4.994 HRD-in -77.36, -61.61 76.79, -35.67 out-in-out SNCoio in-out ActLoopNT-in 2.781 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -96.78, 99.9 APE9-dihe-na 173.74, 169.14 APE8-dihe-in -81.74, 143.07 APE8-rot-out 200.15 APE67-dihe-in -47.45, -41.6 -91.34, -9.3 APE12-dist-none 999.0 APE11-dist-in 12.248 APE10-dist-out 14.98 APE9-dist-out 11.755 H254Y None None XRAY 2.6 0.246 0.277 A 282 259 8 0 0 8 [[133, 383]] 1.0 4o0w CAMK_AURKA_HUMAN CAMK 1.5e-78 269.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4O0UA O14965 126 391 403.0 ADN:501 Type1 Inactive DFGin 6.264 11.43 None -100.67, -17.12 -134.58, 129.02 -80.64, -37.58 28.72, 51.86 64.49, -126.4 out-out out 12.224 Saltbr-out 10.232 HRD-out -138.46, 154.69 -78.12, -46.1 out-in-out SNCoio in-out ActLoopNT-in 3.519 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -78.11, -47.49 APE9-dihe-na -96.12, 155.1 APE8-dihe-in -73.36, 140.7 APE8-rot-out 180.88 APE67-dihe-in -47.54, -36.76 -84.86, -11.52 APE12-dist-out 18.141 APE11-dist-out 15.892 APE10-dist-out 13.345 APE9-dist-out 11.298 H254R None None XRAY 2.6 0.236 0.273 A 282 259 7 0 0 7 [[133, 383]] 1.0 4o0u CAMK_AURKA_HUMAN CAMK 3.5e-78 268.4 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 1MUOA O14965 128 388 403.0 ADN:1 Type1 Inactive DFGinter 5.924 9.006 None -137.2, 91.65 -102.67, 104.14 -141.95, -158.0 317.38, 80.93 -72.97, -80.68 out-out out 11.315 Saltbr-out 7.859 HRD-out -71.01, -147.46 164.07, -11.44 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na -39.4, -7.29 APE9-dihe-na -9.41, -37.67 APE8-dihe-out -44.74, -65.33 APE8-rot-in 311.2 APE67-dihe-in -15.91, -41.07 -76.59, -51.98 APE12-dist-none 999.0 APE11-dist-out 18.196 APE10-dist-out 19.849 APE9-dist-out 11.811 None None None XRAY 2.9 0.26 0.29 A 297 251 10 0 0 10 [[133, 383]] 1.0 1muo CAMK_AURKA_HUMAN CAMK 8.9e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK PIM1 PIM1_HUMAN 1YI4A P11309 33 305 313.0 ADN:306 Type1 Active DFGin 6.072 14.698 BLAminus -134.71, 164.97 59.13, 80.78 -89.82, 21.93 287.09, 72.06 -64.68, -12.33 in-in in 8.788 Saltbr-in 2.717 HRD-na-A -68.53, -44.87 69.57, -1.62 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.9, 36.65 APE9-dihe-na -82.94, -132.28 APE8-dihe-in -114.84, 117.13 APE8-rot-in 309.09 APE67-dihe-in -54.56, -19.23 -51.71, -52.26 APE12-dist-in 9.605 APE11-dist-in 8.674 APE10-dist-in 5.878 APE9-dist-in 4.182 None SEP261 CME161,SEP261 XRAY 2.4 0.21 0.246 A 273 269 4 0 0 0 [[38, 290]] 1.0 1yi4 CAMK_PIM1_HUMAN CAMK 2.4e-65 226.3 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CK1 CSNK1D KC1D_HUMAN 7P7FC P48730 4 294 415.0 ADN:307 Type1 Active DFGin 6.287 14.774 BLAminus -127.27, 170.02 72.27, 90.59 -100.52, 22.08 289.81, 85.32 -63.29, -31.3 in-in in 7.933 Saltbr-in 2.63 HRD-in -80.78, -51.31 76.2, 11.32 in-in-in SNCiii in-in ActLoopNT-in 2.918 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -91.83, -40.42 APE9-dihe-na -88.08, -154.15 APE8-dihe-in -92.07, 119.61 APE8-rot-in 316.8 APE67-dihe-in -56.43, -36.06 -56.0, -37.52 APE12-dist-in 12.693 APE11-dist-in 12.117 APE10-dist-in 6.391 APE9-dist-in 4.324 None TPO220 TPO220 XRAY 1.96 0.19 0.221 C 296 285 6 0 0 6 [[9, 275]] 1.0 7p7f CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7P7FD P48730 4 294 415.0 ADN:309 Type1 Active DFGin 6.224 14.767 BLAminus -126.64, 169.11 73.89, 91.36 -99.69, 21.56 289.8, 84.96 -66.02, -29.96 in-in in 7.952 Saltbr-in 2.667 HRD-in -81.57, -51.69 78.22, 8.75 in-in-in SNCiii in-in ActLoopNT-in 2.894 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -96.24, -37.1 APE9-dihe-na -85.95, -158.82 APE8-dihe-in -90.13, 119.34 APE8-rot-in 319.47 APE67-dihe-in -54.92, -36.79 -58.02, -35.64 APE12-dist-in 13.37 APE11-dist-in 12.222 APE10-dist-in 6.519 APE9-dist-in 4.362 None TPO220 TPO220 XRAY 1.96 0.19 0.221 D 296 285 6 0 0 6 [[9, 275]] 1.0 7p7f CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CMGC CDK9 CDK9_HUMAN 4OGRA P50750 8 330 372.0 ADN:60401 Type1 Active DFGin 6.959 14.852 BLAminus -145.48, 171.71 58.99, 73.11 -88.05, 19.07 282.19, 75.89 -59.04, -25.77 in-in in 8.622 Saltbr-in 3.202 HRD-in -78.29, -48.1 62.83, 28.93 in-in-in SNCiii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.59, 171.14 APE9-dihe-na 70.34, 130.75 APE8-dihe-in -51.49, 135.3 APE8-rot-in 303.62 APE67-dihe-in -61.39, -34.94 -50.28, -42.94 APE12-dist-in 13.245 APE11-dist-in 11.482 APE10-dist-in 6.706 APE9-dist-in 3.205 None TPO186 TPO186 XRAY 3.0 0.206 0.232 A 332 315 8 0 0 0 [[19, 315]] 1.0 4ogr CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CMGC CDK9 CDK9_HUMAN 4OGRE P50750 8 330 372.0 ADN:60401 Type1 Active DFGin 7.086 14.749 BLAminus -145.95, 172.29 59.47, 72.14 -89.89, 19.36 283.65, 75.49 -58.97, -26.2 in-in in 8.801 Saltbr-in 2.931 HRD-in -77.91, -48.96 62.4, 28.78 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.99, 169.74 APE9-dihe-na 65.95, 134.0 APE8-dihe-in -52.43, 138.08 APE8-rot-in 303.65 APE67-dihe-in -62.11, -36.08 -50.82, -43.72 APE12-dist-in 13.214 APE11-dist-in 11.177 APE10-dist-in 6.799 APE9-dist-in 3.429 None TPO186 TPO186 XRAY 3.0 0.206 0.232 E 332 311 12 0 0 0 [[19, 315]] 1.0 4ogr CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CMGC CDK9 CDK9_HUMAN 4OGRI P50750 8 330 372.0 ADN:60401 Type1 Active DFGin 7.02 14.857 BLAminus -146.32, 171.3 58.62, 73.81 -88.0, 20.33 283.45, 75.93 -58.21, -25.18 in-in in 8.754 Saltbr-in 3.252 HRD-in -77.88, -47.68 62.44, 29.24 in-in-in SNCiii in-in ActLoopNT-in 2.937 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.71, 169.37 APE9-dihe-na 67.96, 131.32 APE8-dihe-in -52.01, 135.85 APE8-rot-in 303.33 APE67-dihe-in -60.26, -34.97 -51.39, -42.17 APE12-dist-in 13.226 APE11-dist-in 11.036 APE10-dist-in 6.524 APE9-dist-in 3.127 None TPO186 TPO186 XRAY 3.0 0.206 0.232 I 332 319 4 0 0 0 [[19, 315]] 1.0 4ogr CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CMGC MAPK8 MK08_HUMAN 5LW1B P45983 8 362 427.0 ADN:60401 Type1 Inactive DFGin 4.42 14.448 ABAminus -83.29, -51.84 -118.5, -177.73 -115.08, 20.0 298.98, 87.21 71.2, -159.63 out-out out 10.43 Saltbr-out 3.812 HRD-in -68.61, -60.19 64.51, 12.83 out-out-out SNCooo out-out ActLoopNT-out 6.477 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -136.58, 144.4 APE9-dihe-na -122.04, 105.79 APE8-dihe-out -71.41, -33.58 APE8-rot-in 307.18 APE67-dihe-in -61.62, -32.85 -63.18, -22.53 APE12-dist-out 20.035 APE11-dist-out 18.203 APE10-dist-out 13.764 APE9-dist-out 11.75 None None None XRAY 3.2 0.177 0.212 B 373 355 0 0 0 0 [[26, 321]] 1.0 5lw1 CMGC_MAPK8_HUMAN CMGC 4.7e-84 288.1 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 5LW1E P45983 8 362 427.0 ADN:60401 Type1 Inactive DFGin 4.175 14.075 ABAminus -82.51, -53.19 -119.45, -176.34 -115.64, 20.66 300.14, 87.37 72.63, -160.31 in-out in 9.943 Saltbr-out 4.611 HRD-in -68.12, -61.52 63.83, 14.63 out-out-out SNCooo out-out ActLoopNT-out 6.883 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -137.31, 145.55 APE9-dihe-na -120.94, 104.94 APE8-dihe-out -71.75, -32.64 APE8-rot-in 307.04 APE67-dihe-in -62.19, -31.77 -62.28, -22.63 APE12-dist-out 20.091 APE11-dist-out 18.388 APE10-dist-out 14.086 APE9-dist-out 12.001 None None None XRAY 3.2 0.177 0.212 E 373 355 0 0 0 0 [[26, 321]] 1.0 5lw1 CMGC_MAPK8_HUMAN CMGC 4.7e-84 288.1 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 5LW1H P45983 8 362 427.0 ADN:60401 Type1 Inactive DFGin 4.13 14.378 ABAminus -82.43, -51.23 -118.2, -176.9 -114.7, 20.75 298.45, 87.29 72.11, -159.03 out-out out 10.285 Saltbr-out 3.738 HRD-in -69.31, -61.29 63.64, 13.39 out-out-out SNCooo out-out ActLoopNT-out 6.474 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -136.56, 144.9 APE9-dihe-na -119.98, 105.48 APE8-dihe-out -71.78, -33.35 APE8-rot-in 307.69 APE67-dihe-in -61.37, -31.81 -63.06, -22.73 APE12-dist-out 20.096 APE11-dist-out 18.369 APE10-dist-out 13.965 APE9-dist-out 11.994 None None None XRAY 3.2 0.177 0.212 H 373 355 0 0 0 0 [[26, 321]] 1.0 5lw1 CMGC_MAPK8_HUMAN CMGC 4.7e-84 288.1 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
STE TNIK TNIK_HUMAN 8WM0A Q9UKE5 12 310 1360.0 ADN:401 Type1 Active DFGin 6.684 14.428 BLAminus -137.99, 169.89 73.28, 84.67 -101.61, 23.01 291.08, 82.33 -60.26, -43.27 in-in in 9.699 Saltbr-in 3.566 HRD-in -74.37, -47.31 76.19, -3.3 in-in-in SNCiii in-in ActLoopNT-in 2.94 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.58, 162.14 APE9-dihe-na 103.93, -165.27 APE8-dihe-in -107.19, 120.81 APE8-rot-in 307.37 APE67-dihe-in -60.27, -41.62 -35.76, -53.6 APE12-dist-in 8.707 APE11-dist-in 11.767 APE10-dist-in 6.12 APE9-dist-in 3.42 None TPO181,TPO187 TPO181,TPO187 XRAY 2.8 0.233 0.285 A 306 299 0 0 0 0 [[25, 289]] 1.0 8wm0 STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TKL MAP3K7 M3K7_HUMAN 2EVAA O43318 31 305 606.0 ADN:60498 Type1 Inactive DFGin 5.782 14.522 BLBminus -146.29, -178.1 42.05, 74.22 -66.23, 143.24 303.43, 3.21 -61.8, -26.77 in-in in 8.748 Saltbr-in 3.208 HRD-in -77.52, -49.32 75.21, -17.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 39.52 APE8-dihe-in -17.89, 153.36 APE8-rot-in 310.55 APE67-dihe-in -70.66, -19.63 -64.99, -10.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.095 None None None XRAY 2.0 0.258 0.231 A 307 263 12 0 0 12 [[36, 286]] 1.0 2eva TKL_MAP3K7_HUMAN TKL 3.7e-74 255.5 2 266 265 174 175 176 178 180 63 77 81 153 155 154 156 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
TYR RET RET_HUMAN 6FEKA P07949 705 1010 1114.0 ADN:61104 Type1 Inactive DFGin 6.767 13.821 BLAminus -141.99, -171.41 59.54, 71.43 -98.37, 12.19 284.75, 93.0 -64.4, -26.64 in-none in 7.246 Saltbr-none 999.0 HRD-in -77.44, -40.12 73.87, -24.59 none-in-out SNCnio in-out ActLoopNT-in 2.971 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.75, 17.41 APE9-dihe-in -84.07, 140.52 APE8-dihe-in -58.1, 137.81 APE8-rot-na 331.87 APE67-dihe-in -76.24, -0.91 -55.46, -40.98 APE12-dist-na 13.861 APE11-dist-na 9.442 APE10-dist-na 7.876 APE9-dist-in 5.294 S904F PTR900,PTR905 PTR900,PTR905 XRAY 2.3 0.203 0.244 A 299 291 0 0 0 0 [[724, 1007]] 1.0 6fek TYR_RET_HUMAN TYR 8.2e-101 342.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
TYR RET RET_HUMAN 4CKJA P07949 705 1013 1114.0 ADN:62014 Type1 Inactive DFGin 6.799 14.267 BLAminus -142.57, -173.53 61.96, 74.35 -98.53, 13.01 284.62, 85.56 -60.08, -30.45 in-in in 7.039 Saltbr-in 2.76 HRD-in -74.89, -46.96 77.65, -13.67 in-in-out SNCiio in-out ActLoopNT-in 2.868 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.85, 27.99 APE9-dihe-in -102.95, 135.91 APE8-dihe-in -52.01, 131.39 APE8-rot-na 319.87 APE67-dihe-in -74.49, -6.87 -52.83, -38.38 APE12-dist-na 13.53 APE11-dist-na 9.318 APE10-dist-na 7.901 APE9-dist-in 5.528 None PTR905 PTR905 XRAY 1.65 0.155 0.181 A 314 288 21 0 0 0 [[724, 1007]] 1.0 4ckj TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
TYR RET RET_HUMAN 4CKIA P07949 705 1013 1114.0 ADN:62022 Type1 Inactive DFGin 6.668 14.116 BLAminus -140.51, -172.43 59.47, 75.33 -100.17, 17.92 285.5, 88.95 -62.36, -29.86 in-in in 7.147 Saltbr-in 3.078 HRD-in -77.8, -45.32 75.52, -20.59 in-in-out SNCiio in-out ActLoopNT-in 2.954 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.1, 19.65 APE9-dihe-in -92.48, 138.17 APE8-dihe-in -53.68, 134.11 APE8-rot-na 326.66 APE67-dihe-in -73.39, -8.31 -50.86, -43.32 APE12-dist-na 13.614 APE11-dist-na 9.339 APE10-dist-na 7.871 APE9-dist-in 5.238 M918T PTR900,PTR905 PTR900,PTR905 XRAY 2.116 0.158 0.191 A 314 290 19 0 0 0 [[724, 1007]] 1.0 4cki TYR_RET_HUMAN TYR 1.3e-100 342.0 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret

Ligand: ADN

Total number of chains: 28
Active chains: 12
Total number of genes: 14
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 16 57.1% 5LVNA
DFGin ABAminus 4 14.3% 8SE4B
DFGin None 4 14.3% 4O0UA
None None 2 7.1% 8EWYA
DFGin BLBminus 1 3.6% 2EVAA
DFGinter None 1 3.6% 1MUOA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC LIK M1UWB5_CYAM1 9FMPA M1UWB5 449 809 815.0 ADN:901 Type1 Active DFGin 6.946 14.371 BLAminus -126.69, -178.42 64.87, 88.96 -109.24, 24.93 295.56, 88.61 -76.39, -6.58 in-in in 8.446 Saltbr-in 2.804 HRD-in -86.32, -43.7 69.84, -17.87 in-in-in SNCiii in-in ActLoopNT-in 2.925 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.29, -176.2 APE9-dihe-na 69.63, 141.33 APE8-dihe-in -59.43, 138.59 APE8-rot-in 305.86 APE67-dihe-in -62.53, -19.36 -41.71, -55.06 APE12-dist-in 10.031 APE11-dist-in 11.546 APE10-dist-in 6.856 APE9-dist-in 3.135 None None None XRAY 2.69 0.206 0.268 A 376 361 0 0 0 0 [[468, 806]] 1.0 9fmp Cyanidioschyzon merolae CMGC_LIK_CYAM1 CMGC 9.6e-71 244.5 1 301 301 628 629 630 632 634 497 512 516 597 599 598 600 667 655 650 649 648 647 646 645 644 553 LAMMER-like dual specificity kinase
CMGC LIK M1UWB5_CYAM1 9FMPB M1UWB5 451 808 815.0 ADN:902 Type1 Active DFGin 7.278 14.436 BLAminus -122.95, 178.8 58.14, 81.17 -97.0, 18.78 291.28, 87.76 -69.2, -14.87 in-in in 8.497 Saltbr-in 2.861 HRD-in -75.26, -50.47 74.26, -2.43 in-in-in SNCiii in-in ActLoopNT-in 3.047 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.92, 176.11 APE9-dihe-na 71.64, 149.24 APE8-dihe-in -65.55, 144.2 APE8-rot-in 302.06 APE67-dihe-in -68.68, -10.55 -43.45, -53.0 APE12-dist-in 10.368 APE11-dist-in 11.803 APE10-dist-in 7.332 APE9-dist-in 3.057 None TPO683 TPO683 XRAY 2.69 0.206 0.268 B 376 357 1 0 0 0 [[468, 806]] 1.0 9fmp Cyanidioschyzon merolae CMGC_LIK_CYAM1 CMGC 9.6e-71 244.5 1 301 301 628 629 630 632 634 497 512 516 597 599 598 600 667 655 650 649 648 647 646 645 644 553 LAMMER-like dual specificity kinase
AGC PDPK1 PDPK1_HUMAN 5LVNA O15530 75 359 556.0 ADN:402 Type1 Active DFGin 6.493 14.784 BLAminus -138.56, -175.41 73.41, 75.09 -105.63, 5.44 285.54, 101.95 -63.79, -19.6 in-in in 8.435 Saltbr-in 2.739 HRD-in -74.59, -52.51 78.18, -12.02 in-in-in SNCiii in-in ActLoopNT-in 2.9 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.48, 161.66 APE9-dihe-na 136.02, -164.27 APE8-dihe-in -134.21, 135.25 APE8-rot-in 295.47 APE67-dihe-in -61.9, -23.15 -53.94, -45.84 APE12-dist-in 7.439 APE11-dist-in 10.533 APE10-dist-in 4.893 APE9-dist-in 3.566 Y288G,Q292A SEP241 SEP241 XRAY 1.379 0.135 0.162 A 311 285 0 0 0 0 [[82, 342]] 1.0 5lvn Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PRKCB KPCB_HUMAN 8SE4B P05771 30 671 671.0 ADN:701 Type1 Inactive DFGin 5.738 12.971 ABAminus -126.66, -34.17 -84.97, 112.43 -117.68, 39.4 296.69, 93.7 -74.7, -30.34 in-in in 8.26 Saltbr-in 2.51 HRD-in -88.0, -50.22 70.29, 1.81 in-in-in SNCiii in-in ActLoopNT-in 3.073 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.54, 164.05 APE9-dihe-na 118.34, -179.99 APE8-dihe-in -91.65, 129.4 APE8-rot-in 306.62 APE67-dihe-in -69.42, -21.97 -51.1, -33.02 APE12-dist-in 8.632 APE11-dist-in 11.783 APE10-dist-in 6.261 APE9-dist-in 3.776 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 2.68 0.206 0.258 B 672 589 0 0 0 0 [[342, 600]] 1.0 8se4 Homo sapiens AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
CAMK AURKA AURKA_HUMAN 4O0SA O14965 126 391 403.0 ADN:500 Type1 Inactive DFGin 6.058 16.559 BLAminus -149.62, -178.05 57.82, 65.99 -83.76, 4.5 260.08, 87.32 -48.25, -52.63 out-out out 10.511 Saltbr-out 4.112 HRD-in -67.13, -53.86 77.45, -15.34 out-in-out SNCoio in-out ActLoopNT-in 2.945 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -80.39, -35.33 APE9-dihe-na -145.46, 176.17 APE8-dihe-in -59.32, 141.88 APE8-rot-out 196.74 APE67-dihe-in -51.21, -41.15 -95.86, -1.7 APE12-dist-in 12.477 APE11-dist-in 13.48 APE10-dist-out 10.732 APE9-dist-out 11.027 None None None XRAY 2.5 0.238 0.25 A 282 265 1 0 0 1 [[133, 383]] 1.0 4o0s Homo sapiens CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4O0WA O14965 125 391 403.0 ADN:501 Type1 Inactive DFGin 6.272 16.598 None -99.25, -54.63 -80.04, -74.28 72.86, -1.54 279.35, 93.09 -53.76, -20.49 out-out out 11.319 Saltbr-out 4.994 HRD-in -77.36, -61.61 76.79, -35.67 out-in-out SNCoio in-out ActLoopNT-in 2.781 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -96.78, 99.9 APE9-dihe-na 173.74, 169.14 APE8-dihe-in -81.74, 143.07 APE8-rot-out 200.15 APE67-dihe-in -47.45, -41.6 -91.34, -9.3 APE12-dist-none 999.0 APE11-dist-in 12.248 APE10-dist-out 14.98 APE9-dist-out 11.755 H254Y None None XRAY 2.6 0.246 0.277 A 282 259 8 0 0 8 [[133, 383]] 1.0 4o0w Homo sapiens CAMK_AURKA_HUMAN CAMK 1.5e-78 269.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4O0UA O14965 126 391 403.0 ADN:501 Type1 Inactive DFGin 6.264 11.43 None -100.67, -17.12 -134.58, 129.02 -80.64, -37.58 28.72, 51.86 64.49, -126.4 out-out out 12.224 Saltbr-out 10.232 HRD-out -138.46, 154.69 -78.12, -46.1 out-in-out SNCoio in-out ActLoopNT-in 3.519 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -78.11, -47.49 APE9-dihe-na -96.12, 155.1 APE8-dihe-in -73.36, 140.7 APE8-rot-out 180.88 APE67-dihe-in -47.54, -36.76 -84.86, -11.52 APE12-dist-out 18.141 APE11-dist-out 15.892 APE10-dist-out 13.345 APE9-dist-out 11.298 H254R None None XRAY 2.6 0.236 0.273 A 282 259 7 0 0 7 [[133, 383]] 1.0 4o0u Homo sapiens CAMK_AURKA_HUMAN CAMK 3.5e-78 268.4 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 1MUOA O14965 128 388 403.0 ADN:1 Type1 Inactive DFGinter 5.924 9.006 None -137.2, 91.65 -102.67, 104.14 -141.95, -158.0 317.38, 80.93 -72.97, -80.68 out-out out 11.315 Saltbr-out 7.859 HRD-out -71.01, -147.46 164.07, -11.44 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na -39.4, -7.29 APE9-dihe-na -9.41, -37.67 APE8-dihe-out -44.74, -65.33 APE8-rot-in 311.2 APE67-dihe-in -15.91, -41.07 -76.59, -51.98 APE12-dist-none 999.0 APE11-dist-out 18.196 APE10-dist-out 19.849 APE9-dist-out 11.811 None None None XRAY 2.9 0.26 0.29 A 297 251 10 0 0 10 [[133, 383]] 1.0 1muo Homo sapiens CAMK_AURKA_HUMAN CAMK 8.9e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK PIM1 PIM1_HUMAN 1YI4A P11309 33 305 313.0 ADN:306 Type1 Active DFGin 6.072 14.698 BLAminus -134.71, 164.97 59.13, 80.78 -89.82, 21.93 287.09, 72.06 -64.68, -12.33 in-in in 8.788 Saltbr-in 2.717 HRD-na-A -68.53, -44.87 69.57, -1.62 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.9, 36.65 APE9-dihe-na -82.94, -132.28 APE8-dihe-in -114.84, 117.13 APE8-rot-in 309.09 APE67-dihe-in -54.56, -19.23 -51.71, -52.26 APE12-dist-in 9.605 APE11-dist-in 8.674 APE10-dist-in 5.878 APE9-dist-in 4.182 None SEP261 CME161,SEP261 XRAY 2.4 0.21 0.246 A 273 269 4 0 0 0 [[38, 290]] 1.0 1yi4 Homo sapiens CAMK_PIM1_HUMAN CAMK 2.4e-65 226.3 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CK1 CSNK1D KC1D_HUMAN 7P7FC P48730 4 294 415.0 ADN:307 Type1 Active DFGin 6.287 14.774 BLAminus -127.27, 170.02 72.27, 90.59 -100.52, 22.08 289.81, 85.32 -63.29, -31.3 in-in in 7.933 Saltbr-in 2.63 HRD-in -80.78, -51.31 76.2, 11.32 in-in-in SNCiii in-in ActLoopNT-in 2.918 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -91.83, -40.42 APE9-dihe-na -88.08, -154.15 APE8-dihe-in -92.07, 119.61 APE8-rot-in 316.8 APE67-dihe-in -56.43, -36.06 -56.0, -37.52 APE12-dist-in 12.693 APE11-dist-in 12.117 APE10-dist-in 6.391 APE9-dist-in 4.324 None TPO220 TPO220 XRAY 1.96 0.19 0.221 C 296 285 6 0 0 6 [[9, 275]] 1.0 7p7f Homo sapiens CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7P7FD P48730 4 294 415.0 ADN:309 Type1 Active DFGin 6.224 14.767 BLAminus -126.64, 169.11 73.89, 91.36 -99.69, 21.56 289.8, 84.96 -66.02, -29.96 in-in in 7.952 Saltbr-in 2.667 HRD-in -81.57, -51.69 78.22, 8.75 in-in-in SNCiii in-in ActLoopNT-in 2.894 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -96.24, -37.1 APE9-dihe-na -85.95, -158.82 APE8-dihe-in -90.13, 119.34 APE8-rot-in 319.47 APE67-dihe-in -54.92, -36.79 -58.02, -35.64 APE12-dist-in 13.37 APE11-dist-in 12.222 APE10-dist-in 6.519 APE9-dist-in 4.362 None TPO220 TPO220 XRAY 1.96 0.19 0.221 D 296 285 6 0 0 6 [[9, 275]] 1.0 7p7f Homo sapiens CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CMGC CDK9 CDK9_HUMAN 4OGRA P50750 8 330 372.0 ADN:60401 Type1 Active DFGin 6.959 14.852 BLAminus -145.48, 171.71 58.99, 73.11 -88.05, 19.07 282.19, 75.89 -59.04, -25.77 in-in in 8.622 Saltbr-in 3.202 HRD-in -78.29, -48.1 62.83, 28.93 in-in-in SNCiii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.59, 171.14 APE9-dihe-na 70.34, 130.75 APE8-dihe-in -51.49, 135.3 APE8-rot-in 303.62 APE67-dihe-in -61.39, -34.94 -50.28, -42.94 APE12-dist-in 13.245 APE11-dist-in 11.482 APE10-dist-in 6.706 APE9-dist-in 3.205 None TPO186 TPO186 XRAY 3.0 0.206 0.232 A 332 315 8 0 0 0 [[19, 315]] 1.0 4ogr Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CMGC CDK9 CDK9_HUMAN 4OGRE P50750 8 330 372.0 ADN:60401 Type1 Active DFGin 7.086 14.749 BLAminus -145.95, 172.29 59.47, 72.14 -89.89, 19.36 283.65, 75.49 -58.97, -26.2 in-in in 8.801 Saltbr-in 2.931 HRD-in -77.91, -48.96 62.4, 28.78 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.99, 169.74 APE9-dihe-na 65.95, 134.0 APE8-dihe-in -52.43, 138.08 APE8-rot-in 303.65 APE67-dihe-in -62.11, -36.08 -50.82, -43.72 APE12-dist-in 13.214 APE11-dist-in 11.177 APE10-dist-in 6.799 APE9-dist-in 3.429 None TPO186 TPO186 XRAY 3.0 0.206 0.232 E 332 311 12 0 0 0 [[19, 315]] 1.0 4ogr Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CMGC CDK9 CDK9_HUMAN 4OGRI P50750 8 330 372.0 ADN:60401 Type1 Active DFGin 7.02 14.857 BLAminus -146.32, 171.3 58.62, 73.81 -88.0, 20.33 283.45, 75.93 -58.21, -25.18 in-in in 8.754 Saltbr-in 3.252 HRD-in -77.88, -47.68 62.44, 29.24 in-in-in SNCiii in-in ActLoopNT-in 2.937 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.71, 169.37 APE9-dihe-na 67.96, 131.32 APE8-dihe-in -52.01, 135.85 APE8-rot-in 303.33 APE67-dihe-in -60.26, -34.97 -51.39, -42.17 APE12-dist-in 13.226 APE11-dist-in 11.036 APE10-dist-in 6.524 APE9-dist-in 3.127 None TPO186 TPO186 XRAY 3.0 0.206 0.232 I 332 319 4 0 0 0 [[19, 315]] 1.0 4ogr Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CMGC MAPK8 MK08_HUMAN 5LW1B P45983 8 362 427.0 ADN:60401 Type1 Inactive DFGin 4.42 14.448 ABAminus -83.29, -51.84 -118.5, -177.73 -115.08, 20.0 298.98, 87.21 71.2, -159.63 out-out out 10.43 Saltbr-out 3.812 HRD-in -68.61, -60.19 64.51, 12.83 out-out-out SNCooo out-out ActLoopNT-out 6.477 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -136.58, 144.4 APE9-dihe-na -122.04, 105.79 APE8-dihe-out -71.41, -33.58 APE8-rot-in 307.18 APE67-dihe-in -61.62, -32.85 -63.18, -22.53 APE12-dist-out 20.035 APE11-dist-out 18.203 APE10-dist-out 13.764 APE9-dist-out 11.75 None None None XRAY 3.2 0.177 0.212 B 373 355 0 0 0 0 [[26, 321]] 1.0 5lw1 Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.7e-84 288.1 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 5LW1E P45983 8 362 427.0 ADN:60401 Type1 Inactive DFGin 4.175 14.075 ABAminus -82.51, -53.19 -119.45, -176.34 -115.64, 20.66 300.14, 87.37 72.63, -160.31 in-out in 9.943 Saltbr-out 4.611 HRD-in -68.12, -61.52 63.83, 14.63 out-out-out SNCooo out-out ActLoopNT-out 6.883 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -137.31, 145.55 APE9-dihe-na -120.94, 104.94 APE8-dihe-out -71.75, -32.64 APE8-rot-in 307.04 APE67-dihe-in -62.19, -31.77 -62.28, -22.63 APE12-dist-out 20.091 APE11-dist-out 18.388 APE10-dist-out 14.086 APE9-dist-out 12.001 None None None XRAY 3.2 0.177 0.212 E 373 355 0 0 0 0 [[26, 321]] 1.0 5lw1 Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.7e-84 288.1 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 5LW1H P45983 8 362 427.0 ADN:60401 Type1 Inactive DFGin 4.13 14.378 ABAminus -82.43, -51.23 -118.2, -176.9 -114.7, 20.75 298.45, 87.29 72.11, -159.03 out-out out 10.285 Saltbr-out 3.738 HRD-in -69.31, -61.29 63.64, 13.39 out-out-out SNCooo out-out ActLoopNT-out 6.474 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -136.56, 144.9 APE9-dihe-na -119.98, 105.48 APE8-dihe-out -71.78, -33.35 APE8-rot-in 307.69 APE67-dihe-in -61.37, -31.81 -63.06, -22.73 APE12-dist-out 20.096 APE11-dist-out 18.369 APE10-dist-out 13.965 APE9-dist-out 11.994 None None None XRAY 3.2 0.177 0.212 H 373 355 0 0 0 0 [[26, 321]] 1.0 5lw1 Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.7e-84 288.1 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
STE TNIK TNIK_HUMAN 8WM0A Q9UKE5 12 310 1360.0 ADN:401 Type1 Active DFGin 6.684 14.428 BLAminus -137.99, 169.89 73.28, 84.67 -101.61, 23.01 291.08, 82.33 -60.26, -43.27 in-in in 9.699 Saltbr-in 3.566 HRD-in -74.37, -47.31 76.19, -3.3 in-in-in SNCiii in-in ActLoopNT-in 2.94 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.58, 162.14 APE9-dihe-na 103.93, -165.27 APE8-dihe-in -107.19, 120.81 APE8-rot-in 307.37 APE67-dihe-in -60.27, -41.62 -35.76, -53.6 APE12-dist-in 8.707 APE11-dist-in 11.767 APE10-dist-in 6.12 APE9-dist-in 3.42 None TPO181,TPO187 TPO181,TPO187 XRAY 2.8 0.233 0.285 A 306 299 0 0 0 0 [[25, 289]] 1.0 8wm0 Homo sapiens STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TKL MAP3K7 M3K7_HUMAN 2EVAA O43318 31 305 606.0 ADN:60498 Type1 Inactive DFGin 5.782 14.522 BLBminus -146.29, -178.1 42.05, 74.22 -66.23, 143.24 303.43, 3.21 -61.8, -26.77 in-in in 8.748 Saltbr-in 3.208 HRD-in -77.52, -49.32 75.21, -17.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 39.52 APE8-dihe-in -17.89, 153.36 APE8-rot-in 310.55 APE67-dihe-in -70.66, -19.63 -64.99, -10.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.095 None None None XRAY 2.0 0.258 0.231 A 307 263 12 0 0 12 [[36, 286]] 1.0 2eva Homo sapiens TKL_MAP3K7_HUMAN TKL 3.7e-74 255.5 2 266 265 174 175 176 178 180 63 77 81 153 155 154 156 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
TYR RET RET_HUMAN 6FEKA P07949 705 1010 1114.0 ADN:61104 Type1 Inactive DFGin 6.767 13.821 BLAminus -141.99, -171.41 59.54, 71.43 -98.37, 12.19 284.75, 93.0 -64.4, -26.64 in-none in 7.246 Saltbr-none 999.0 HRD-in -77.44, -40.12 73.87, -24.59 none-in-out SNCnio in-out ActLoopNT-in 2.971 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.75, 17.41 APE9-dihe-in -84.07, 140.52 APE8-dihe-in -58.1, 137.81 APE8-rot-na 331.87 APE67-dihe-in -76.24, -0.91 -55.46, -40.98 APE12-dist-na 13.861 APE11-dist-na 9.442 APE10-dist-na 7.876 APE9-dist-in 5.294 S904F PTR900,PTR905 PTR900,PTR905 XRAY 2.3 0.203 0.244 A 299 291 0 0 0 0 [[724, 1007]] 1.0 6fek Homo sapiens TYR_RET_HUMAN TYR 8.2e-101 342.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
TYR RET RET_HUMAN 4CKJA P07949 705 1013 1114.0 ADN:62014 Type1 Inactive DFGin 6.799 14.267 BLAminus -142.57, -173.53 61.96, 74.35 -98.53, 13.01 284.62, 85.56 -60.08, -30.45 in-in in 7.039 Saltbr-in 2.76 HRD-in -74.89, -46.96 77.65, -13.67 in-in-out SNCiio in-out ActLoopNT-in 2.868 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.85, 27.99 APE9-dihe-in -102.95, 135.91 APE8-dihe-in -52.01, 131.39 APE8-rot-na 319.87 APE67-dihe-in -74.49, -6.87 -52.83, -38.38 APE12-dist-na 13.53 APE11-dist-na 9.318 APE10-dist-na 7.901 APE9-dist-in 5.528 None PTR905 PTR905 XRAY 1.65 0.155 0.181 A 314 288 21 0 0 0 [[724, 1007]] 1.0 4ckj Homo sapiens TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
TYR RET RET_HUMAN 4CKIA P07949 705 1013 1114.0 ADN:62022 Type1 Inactive DFGin 6.668 14.116 BLAminus -140.51, -172.43 59.47, 75.33 -100.17, 17.92 285.5, 88.95 -62.36, -29.86 in-in in 7.147 Saltbr-in 3.078 HRD-in -77.8, -45.32 75.52, -20.59 in-in-out SNCiio in-out ActLoopNT-in 2.954 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.1, 19.65 APE9-dihe-in -92.48, 138.17 APE8-dihe-in -53.68, 134.11 APE8-rot-na 326.66 APE67-dihe-in -73.39, -8.31 -50.86, -43.32 APE12-dist-na 13.614 APE11-dist-na 9.339 APE10-dist-na 7.871 APE9-dist-in 5.238 M918T PTR900,PTR905 PTR900,PTR905 XRAY 2.116 0.158 0.191 A 314 290 19 0 0 0 [[724, 1007]] 1.0 4cki Homo sapiens TYR_RET_HUMAN TYR 1.3e-100 342.0 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
AGC PRKACA KAPCA_MOUSE 1FMOE P05132 14 351 351.0 ADN:60351 Type1 Active DFGin 6.678 14.282 BLAminus -114.95, 166.87 67.95, 101.15 -111.54, 7.58 268.05, 65.13 -43.18, -17.52 in-in in 8.56 Saltbr-in 2.982 HRD-in -73.08, -60.95 74.44, -3.64 in-in-in SNCiii in-in ActLoopNT-in 2.86 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.53, 167.98 APE9-dihe-na 127.76, -157.13 APE8-dihe-in -115.17, 123.5 APE8-rot-in 303.04 APE67-dihe-in -62.85, -32.38 -37.72, -49.63 APE12-dist-in 7.934 APE11-dist-in 11.276 APE10-dist-in 5.947 APE9-dist-in 3.712 None TPO198,SEP339 TPO198,SEP339 XRAY 2.2 0.182 999.0 E 350 338 0 0 0 0 [[44, 298]] 1.0 1fmo Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
TYR JAK1-12 JAK1_MOUSE 7T6FA P52332 32 1153 1153.0 ADN:61201,ADP:61202 Allosteric,ATPlike Inactive DFGin 6.899 13.813 None -86.13, -125.98 -78.37, 170.67 -132.74, 42.36 300.4, 95.7 -63.52, -44.16 in-out in 8.266 Saltbr-out 5.345 HRD-in -74.55, -24.53 68.9, -7.15 out-in-out SNCoio in-out ActLoopNT-in 3.366 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -74.97, -30.61 APE9-dihe-in -69.86, 145.09 APE8-dihe-in -65.5, 154.45 APE8-rot-na 337.81 APE67-dihe-in -111.81, 34.03 -69.03, -47.03 APE12-dist-na 13.07 APE11-dist-na 13.989 APE10-dist-na 8.674 APE9-dist-in 6.36 None None None EM 3.6 999.0 999.0 A 1173 1043 23 0 0 0 [[582, 846], [874, 1150]] 2.0 7t6f Mus musculus TYR_JAK1-12_MOUSE TYR 7.5e-59 499.6 3 260 516 1019 1020 1021 1023 1025 907 924 928 999 1001 1000 1002 1062 1050 1045 1044 1043 1042 1041 1040 1039 956 Tyrosine-protein kinase JAK1
TYR JAK1-12 JAK1_MOUSE 7T6FB P52332 32 1153 1153.0 ADN:61201,ADP:61202 Allosteric,ATPlike Inactive DFGin 6.898 13.813 None -86.09, -125.95 -78.45, 170.72 -132.73, 42.29 300.45, 95.61 -63.42, -44.2 in-out in 8.267 Saltbr-out 5.347 HRD-in -74.65, -24.42 68.9, -7.11 out-in-out SNCoio in-out ActLoopNT-in 3.366 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -74.91, -30.65 APE9-dihe-in -69.79, 145.09 APE8-dihe-in -65.5, 154.47 APE8-rot-na 337.81 APE67-dihe-in -111.9, 34.05 -69.03, -46.98 APE12-dist-na 13.069 APE11-dist-na 13.989 APE10-dist-na 8.673 APE9-dist-in 6.36 None None None EM 3.6 999.0 999.0 B 1173 1043 23 0 0 0 [[582, 846], [874, 1150]] 2.0 7t6f Mus musculus TYR_JAK1-12_MOUSE TYR 7.5e-59 499.6 3 260 516 1019 1020 1021 1023 1025 907 924 928 999 1001 1000 1002 1062 1050 1045 1044 1043 1042 1041 1040 1039 956 Tyrosine-protein kinase JAK1
TYR JAK1-12 JAK1_MOUSE 8EWYA P52332 32 1153 1153.0 ADN:61201,ADP:61202 Allosteric,ATPlike Inactive None 999.0 999.0 None -138.68, -158.74 57.84, 53.41 -86.5, 17.2 999.0, 999.0 -66.33, -21.83 in-none in 8.079 Saltbr-none 999.0 HRD-in -63.86, -38.24 65.99, -1.42 none-in-in SNCnii in-in ActLoopNT-in 2.841 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.88, 139.03 APE9-dihe-in -137.63, 148.1 APE8-dihe-in -70.82, 80.23 APE8-rot-na 999.0 APE67-dihe-in -71.32, -12.38 -60.07, -30.97 APE12-dist-na 13.002 APE11-dist-na 7.928 APE10-dist-na 11.009 APE9-dist-in 6.342 V657F None None EM 5.5 999.0 999.0 A 1173 1047 19 0 0 0 [[582, 846], [874, 1150]] 2.0 8ewy Mus musculus TYR_JAK1-12_MOUSE TYR 7.5e-59 499.6 3 260 516 1019 1020 1021 1023 1025 907 924 928 999 1001 1000 1002 1062 1050 1045 1044 1043 1042 1041 1040 1039 956 Tyrosine-protein kinase JAK1
TYR JAK1-12 JAK1_MOUSE 8EWYB P52332 32 1153 1153.0 ADN:61201,ADP:61202 Allosteric,ATPlike Inactive None 999.0 999.0 None -138.65, -158.76 57.86, 53.37 -86.37, 17.05 999.0, 999.0 -66.24, -21.9 in-none in 8.079 Saltbr-none 999.0 HRD-in -63.87, -38.25 66.06, -1.5 none-in-in SNCnii in-in ActLoopNT-in 2.842 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.87, 139.06 APE9-dihe-in -137.62, 148.16 APE8-dihe-in -70.91, 80.26 APE8-rot-na 999.0 APE67-dihe-in -71.25, -12.38 -60.08, -31.01 APE12-dist-na 13.002 APE11-dist-na 7.928 APE10-dist-na 11.009 APE9-dist-in 6.341 V657F None None EM 5.5 999.0 999.0 B 1173 1047 19 0 0 0 [[582, 846], [874, 1150]] 2.0 8ewy Mus musculus TYR_JAK1-12_MOUSE TYR 7.5e-59 499.6 3 260 516 1019 1020 1021 1023 1025 907 924 928 999 1001 1000 1002 1062 1050 1045 1044 1043 1042 1041 1040 1039 956 Tyrosine-protein kinase JAK1
CMGC SKY1 SKY1_YEAST 1Q97B Q03656 145 737 742.0 ADN:60486 Type1 Active DFGin 5.815 12.952 BLAminus -104.57, 173.13 44.98, 86.84 -90.28, 23.6 296.08, 17.77 -63.17, -24.44 in-in in 8.846 Saltbr-in 3.266 HRD-in -73.58, -45.0 72.28, -6.95 in-in-in SNCiii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.01, 170.7 APE9-dihe-na 67.39, 158.89 APE8-dihe-in -97.9, 143.15 APE8-rot-in 292.96 APE67-dihe-in -50.21, -30.65 -20.49, -80.35 APE12-dist-in 12.564 APE11-dist-in 10.52 APE10-dist-in 7.605 APE9-dist-in 3.025 None None None XRAY 2.3 0.215 0.264 B 373 361 0 0 0 0 [[158, 706]] 1.0 1q97 Saccharomyces cerevisiae CMGC_SKY1_YEAST CMGC 8.8e-100 339.7 1 301 301 549 550 551 553 555 187 202 206 291 293 292 294 586 574 569 568 567 566 565 564 563 247 Serine/threonine-protein kinase SKY1

Ligand: ADN

Total number of chains: 8
Active chains: 4
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 50.0% 1FMOE
DFGin None 2 25.0% 7T6FA
None None 2 25.0% 8EWYA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC LIK M1UWB5_CYAM1 9FMPA M1UWB5 449 809 815.0 ADN:901 Type1 Active DFGin 6.946 14.371 BLAminus -126.69, -178.42 64.87, 88.96 -109.24, 24.93 295.56, 88.61 -76.39, -6.58 in-in in 8.446 Saltbr-in 2.804 HRD-in -86.32, -43.7 69.84, -17.87 in-in-in SNCiii in-in ActLoopNT-in 2.925 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.29, -176.2 APE9-dihe-na 69.63, 141.33 APE8-dihe-in -59.43, 138.59 APE8-rot-in 305.86 APE67-dihe-in -62.53, -19.36 -41.71, -55.06 APE12-dist-in 10.031 APE11-dist-in 11.546 APE10-dist-in 6.856 APE9-dist-in 3.135 None None None XRAY 2.69 0.206 0.268 A 376 361 0 0 0 0 [[468, 806]] 1.0 9fmp Cyanidioschyzon merolae CMGC_LIK_CYAM1 CMGC 9.6e-71 244.5 1 301 301 628 629 630 632 634 497 512 516 597 599 598 600 667 655 650 649 648 647 646 645 644 553 LAMMER-like dual specificity kinase
CMGC LIK M1UWB5_CYAM1 9FMPB M1UWB5 451 808 815.0 ADN:902 Type1 Active DFGin 7.278 14.436 BLAminus -122.95, 178.8 58.14, 81.17 -97.0, 18.78 291.28, 87.76 -69.2, -14.87 in-in in 8.497 Saltbr-in 2.861 HRD-in -75.26, -50.47 74.26, -2.43 in-in-in SNCiii in-in ActLoopNT-in 3.047 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.92, 176.11 APE9-dihe-na 71.64, 149.24 APE8-dihe-in -65.55, 144.2 APE8-rot-in 302.06 APE67-dihe-in -68.68, -10.55 -43.45, -53.0 APE12-dist-in 10.368 APE11-dist-in 11.803 APE10-dist-in 7.332 APE9-dist-in 3.057 None TPO683 TPO683 XRAY 2.69 0.206 0.268 B 376 357 1 0 0 0 [[468, 806]] 1.0 9fmp Cyanidioschyzon merolae CMGC_LIK_CYAM1 CMGC 9.6e-71 244.5 1 301 301 628 629 630 632 634 497 512 516 597 599 598 600 667 655 650 649 648 647 646 645 644 553 LAMMER-like dual specificity kinase
AGC PRKACA KAPCA_MOUSE 1FMOE P05132 14 351 351.0 ADN:60351 Type1 Active DFGin 6.678 14.282 BLAminus -114.95, 166.87 67.95, 101.15 -111.54, 7.58 268.05, 65.13 -43.18, -17.52 in-in in 8.56 Saltbr-in 2.982 HRD-in -73.08, -60.95 74.44, -3.64 in-in-in SNCiii in-in ActLoopNT-in 2.86 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.53, 167.98 APE9-dihe-na 127.76, -157.13 APE8-dihe-in -115.17, 123.5 APE8-rot-in 303.04 APE67-dihe-in -62.85, -32.38 -37.72, -49.63 APE12-dist-in 7.934 APE11-dist-in 11.276 APE10-dist-in 5.947 APE9-dist-in 3.712 None TPO198,SEP339 TPO198,SEP339 XRAY 2.2 0.182 999.0 E 350 338 0 0 0 0 [[44, 298]] 1.0 1fmo Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
TYR JAK1-12 JAK1_MOUSE 7T6FA P52332 32 1153 1153.0 ADN:61201,ADP:61202 Allosteric,ATPlike Inactive DFGin 6.899 13.813 None -86.13, -125.98 -78.37, 170.67 -132.74, 42.36 300.4, 95.7 -63.52, -44.16 in-out in 8.266 Saltbr-out 5.345 HRD-in -74.55, -24.53 68.9, -7.15 out-in-out SNCoio in-out ActLoopNT-in 3.366 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -74.97, -30.61 APE9-dihe-in -69.86, 145.09 APE8-dihe-in -65.5, 154.45 APE8-rot-na 337.81 APE67-dihe-in -111.81, 34.03 -69.03, -47.03 APE12-dist-na 13.07 APE11-dist-na 13.989 APE10-dist-na 8.674 APE9-dist-in 6.36 None None None EM 3.6 999.0 999.0 A 1173 1043 23 0 0 0 [[582, 846], [874, 1150]] 2.0 7t6f Mus musculus TYR_JAK1-12_MOUSE TYR 7.5e-59 499.6 3 260 516 1019 1020 1021 1023 1025 907 924 928 999 1001 1000 1002 1062 1050 1045 1044 1043 1042 1041 1040 1039 956 Tyrosine-protein kinase JAK1
TYR JAK1-12 JAK1_MOUSE 7T6FB P52332 32 1153 1153.0 ADN:61201,ADP:61202 Allosteric,ATPlike Inactive DFGin 6.898 13.813 None -86.09, -125.95 -78.45, 170.72 -132.73, 42.29 300.45, 95.61 -63.42, -44.2 in-out in 8.267 Saltbr-out 5.347 HRD-in -74.65, -24.42 68.9, -7.11 out-in-out SNCoio in-out ActLoopNT-in 3.366 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -74.91, -30.65 APE9-dihe-in -69.79, 145.09 APE8-dihe-in -65.5, 154.47 APE8-rot-na 337.81 APE67-dihe-in -111.9, 34.05 -69.03, -46.98 APE12-dist-na 13.069 APE11-dist-na 13.989 APE10-dist-na 8.673 APE9-dist-in 6.36 None None None EM 3.6 999.0 999.0 B 1173 1043 23 0 0 0 [[582, 846], [874, 1150]] 2.0 7t6f Mus musculus TYR_JAK1-12_MOUSE TYR 7.5e-59 499.6 3 260 516 1019 1020 1021 1023 1025 907 924 928 999 1001 1000 1002 1062 1050 1045 1044 1043 1042 1041 1040 1039 956 Tyrosine-protein kinase JAK1
TYR JAK1-12 JAK1_MOUSE 8EWYA P52332 32 1153 1153.0 ADN:61201,ADP:61202 Allosteric,ATPlike Inactive None 999.0 999.0 None -138.68, -158.74 57.84, 53.41 -86.5, 17.2 999.0, 999.0 -66.33, -21.83 in-none in 8.079 Saltbr-none 999.0 HRD-in -63.86, -38.24 65.99, -1.42 none-in-in SNCnii in-in ActLoopNT-in 2.841 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.88, 139.03 APE9-dihe-in -137.63, 148.1 APE8-dihe-in -70.82, 80.23 APE8-rot-na 999.0 APE67-dihe-in -71.32, -12.38 -60.07, -30.97 APE12-dist-na 13.002 APE11-dist-na 7.928 APE10-dist-na 11.009 APE9-dist-in 6.342 V657F None None EM 5.5 999.0 999.0 A 1173 1047 19 0 0 0 [[582, 846], [874, 1150]] 2.0 8ewy Mus musculus TYR_JAK1-12_MOUSE TYR 7.5e-59 499.6 3 260 516 1019 1020 1021 1023 1025 907 924 928 999 1001 1000 1002 1062 1050 1045 1044 1043 1042 1041 1040 1039 956 Tyrosine-protein kinase JAK1
TYR JAK1-12 JAK1_MOUSE 8EWYB P52332 32 1153 1153.0 ADN:61201,ADP:61202 Allosteric,ATPlike Inactive None 999.0 999.0 None -138.65, -158.76 57.86, 53.37 -86.37, 17.05 999.0, 999.0 -66.24, -21.9 in-none in 8.079 Saltbr-none 999.0 HRD-in -63.87, -38.25 66.06, -1.5 none-in-in SNCnii in-in ActLoopNT-in 2.842 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.87, 139.06 APE9-dihe-in -137.62, 148.16 APE8-dihe-in -70.91, 80.26 APE8-rot-na 999.0 APE67-dihe-in -71.25, -12.38 -60.08, -31.01 APE12-dist-na 13.002 APE11-dist-na 7.928 APE10-dist-na 11.009 APE9-dist-in 6.341 V657F None None EM 5.5 999.0 999.0 B 1173 1047 19 0 0 0 [[582, 846], [874, 1150]] 2.0 8ewy Mus musculus TYR_JAK1-12_MOUSE TYR 7.5e-59 499.6 3 260 516 1019 1020 1021 1023 1025 907 924 928 999 1001 1000 1002 1062 1050 1045 1044 1043 1042 1041 1040 1039 956 Tyrosine-protein kinase JAK1
CMGC SKY1 SKY1_YEAST 1Q97B Q03656 145 737 742.0 ADN:60486 Type1 Active DFGin 5.815 12.952 BLAminus -104.57, 173.13 44.98, 86.84 -90.28, 23.6 296.08, 17.77 -63.17, -24.44 in-in in 8.846 Saltbr-in 3.266 HRD-in -73.58, -45.0 72.28, -6.95 in-in-in SNCiii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.01, 170.7 APE9-dihe-na 67.39, 158.89 APE8-dihe-in -97.9, 143.15 APE8-rot-in 292.96 APE67-dihe-in -50.21, -30.65 -20.49, -80.35 APE12-dist-in 12.564 APE11-dist-in 10.52 APE10-dist-in 7.605 APE9-dist-in 3.025 None None None XRAY 2.3 0.215 0.264 B 373 361 0 0 0 0 [[158, 706]] 1.0 1q97 Saccharomyces cerevisiae CMGC_SKY1_YEAST CMGC 8.8e-100 339.7 1 301 301 549 550 551 553 555 187 202 206 291 293 292 294 586 574 569 568 567 566 565 564 563 247 Serine/threonine-protein kinase SKY1