TKL_IRAK4 (Interleukin-1 receptor-associated kinase 4)

Total number of chains: 284
Active chains: 87
Uniprot: IRAK4_HUMAN
Kinase Domain Residues: 175 - 456
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 271 95.4% AF-Q9NWZ3-K1A
DFGout None 4 1.4% 6EG9A
DFGin None 3 1.1% 8TVMD
DFGin BLBminus 2 0.7% 2NRYA
None None 2 0.7% 8TVND
DFGin BLAplus 1 0.4% 9R9KC
DFGin BLBtrans 1 0.4% 6EGFB

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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
IRAK4 2OIDD Q9NWZ3 164 459 460.0 ANP:4 ATPlike Active DFGin 6.5602 13.9721 BLAminus -129.12, -177.03 59.13, 109.88 -131.38, 17.54 304.54, 87.5 -68.37, -4.63 in-in in 8.1503 Saltbr-in 3.5198 HRD-in -75.54, -51.34 70.58, 2.03 in-in-in SNCiii in-in ActLoopNT-in 2.7649 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.72, 147.52 APE9-dihe-na 139.0, -173.6 APE8-dihe-in -107.1, 118.58 APE8-rot-in 309.04 APE67-dihe-in -62.68, -15.82 -47.4, -49.91 APE12-dist-in 9.7501 APE11-dist-in 11.4404 APE10-dist-in 5.9279 APE9-dist-in 3.9698 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.244 0.295 D 301.0 277.0 19 30 27 3 [[183, 456]] 1.0 2oid TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 AF-Q9NWZ3-K1A Q9NWZ3 167 460 460.0 No_ligand No_ligand Active DFGin 6.8118 13.6643 BLAminus -132.76, 172.69 67.25, 69.59 -89.82, 12.24 307.87, 90.6 -59.49, -31.68 in-in in 8.8545 Saltbr-in 3.3486 HRD-in -71.59, -45.27 70.03, -5.05 in-in-in SNCiii in-in ActLoopNT-in 2.871 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.66, 156.28 APE9-dihe-na 122.41, 177.96 APE8-dihe-in -94.38, 113.56 APE8-rot-in 308.42 APE67-dihe-in -63.16, -15.22 -47.64, -42.49 APE12-dist-in 9.9128 APE11-dist-in 11.7505 APE10-dist-in 6.2739 APE9-dist-in 3.8166 None None None AF2 -1.0 1.0 1.0 A 294.0 294.0 0 30 30 0 [[183, 456]] 1.0 AF-Q9NWZ3-K1 TKL_IRAK4_HUMAN TKL 3.7e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 AF-Q9NWZ3-K3A Q9NWZ3 167 460 460.0 No_ligand No_ligand Active DFGin 6.7864 14.0038 BLAminus -132.19, 177.79 65.89, 57.73 -81.1, 6.78 299.4, 89.77 -58.62, -25.66 in-in in 8.8744 Saltbr-in 3.0276 HRD-in -74.86, -42.43 71.98, -8.96 in-in-in SNCiii in-in ActLoopNT-in 2.8504 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.5, 149.42 APE9-dihe-na 114.46, -176.54 APE8-dihe-in -91.44, 118.0 APE8-rot-in 299.76 APE67-dihe-in -61.58, -17.39 -51.41, -39.95 APE12-dist-in 10.2044 APE11-dist-in 11.6384 APE10-dist-in 6.1636 APE9-dist-in 4.2957 None None None AF2 -1.0 1.0 1.0 A 294.0 294.0 0 30 30 0 [[183, 456]] 1.0 AF-Q9NWZ3-K3 TKL_IRAK4_HUMAN TKL 3.7e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 2OIBA Q9NWZ3 162 458 460.0 No_ligand No_ligand Active DFGin 7.2364 14.0842 BLAminus -134.16, -176.28 54.93, 81.04 -100.11, 21.09 297.23, 89.01 -65.48, -18.31 in-in in 9.1219 Saltbr-in 2.8468 HRD-in -68.64, -53.67 81.53, -4.3 in-in-in SNCiii in-in ActLoopNT-in 2.6863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.86, 156.66 APE9-dihe-na 135.28, -174.63 APE8-dihe-in -110.16, 113.63 APE8-rot-in 304.76 APE67-dihe-in -68.16, -10.88 -49.28, -45.36 APE12-dist-in 10.0718 APE11-dist-in 11.7658 APE10-dist-in 6.4573 APE9-dist-in 3.9204 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.0 0.224 0.27 A 301.0 283.0 14 30 26 4 [[183, 456]] 1.0 2oib TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 2OIBC Q9NWZ3 161 458 460.0 No_ligand No_ligand Active DFGin 6.7825 13.9217 BLAminus -128.61, -179.25 54.07, 81.1 -99.0, 24.35 303.67, 85.85 -70.18, -11.07 in-in in 9.001 Saltbr-in 2.7478 HRD-in -69.66, -51.82 77.63, -0.65 in-in-in SNCiii in-in ActLoopNT-in 2.7889 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.16, 161.47 APE9-dihe-na 128.44, -177.87 APE8-dihe-in -108.48, 112.83 APE8-rot-in 306.45 APE67-dihe-in -63.49, -17.45 -45.36, -47.81 APE12-dist-in 9.7554 APE11-dist-in 11.7364 APE10-dist-in 6.1609 APE9-dist-in 3.6923 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.0 0.224 0.27 C 301.0 281.0 17 30 26 4 [[183, 456]] 1.0 2oib TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6F3GA Q9NWZ3 164 458 460.0 CJN:501 Type1 Active DFGin 6.9344 14.6905 BLAminus -122.32, 172.07 57.35, 82.28 -97.19, 19.83 304.44, 114.9 -63.17, -27.04 in-in in 9.3591 Saltbr-in 3.2345 HRD-in -67.41, -50.37 77.63, -5.5 in-in-in SNCiii in-in ActLoopNT-in 2.8163 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.97, 162.51 APE9-dihe-na 125.59, -169.48 APE8-dihe-in -113.67, 112.77 APE8-rot-in 308.62 APE67-dihe-in -62.16, -14.53 -45.05, -47.73 APE12-dist-in 10.3673 APE11-dist-in 11.9291 APE10-dist-in 6.368 APE9-dist-in 3.7361 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.37 0.291 0.314 A 295.0 277.0 18 30 24 6 [[183, 456]] 1.0 6f3g TKL_IRAK4_HUMAN TKL 3.8e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6F3GB Q9NWZ3 164 458 460.0 CJN:502 Type1 Active DFGin 6.7463 14.91 BLAminus -124.8, 172.93 59.11, 81.24 -96.73, 18.74 302.18, 100.23 -62.68, -27.88 in-in in 9.5668 Saltbr-in 3.2461 HRD-in -66.44, -50.77 77.64, -6.42 in-in-in SNCiii in-in ActLoopNT-in 2.8172 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.34, 162.98 APE9-dihe-na 126.47, -168.92 APE8-dihe-in -114.13, 114.0 APE8-rot-in 308.7 APE67-dihe-in -62.55, -14.66 -47.56, -45.83 APE12-dist-in 10.3152 APE11-dist-in 11.7999 APE10-dist-in 6.2953 APE9-dist-in 3.7574 None TPO345,SEP346 TPO345,SEP346 XRAY 2.37 0.291 0.314 B 295.0 279.0 16 30 24 6 [[183, 456]] 1.0 6f3g TKL_IRAK4_HUMAN TKL 3.8e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6N8GA Q9NWZ3 164 459 460.0 KFD:501 Type1 Active DFGin 6.8567 13.8503 BLAminus -131.56, 170.5 74.43, 93.31 -112.82, 5.9 310.67, 99.35 -50.67, -35.36 in-in in 8.7028 Saltbr-in 3.3998 HRD-in -74.01, -49.56 80.73, -4.62 in-in-in SNCiii in-in ActLoopNT-in 2.7886 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.5, 156.4 APE9-dihe-na 134.1, -163.0 APE8-dihe-in -125.24, 115.56 APE8-rot-in 300.55 APE67-dihe-in -58.51, -21.49 -57.72, -36.7 APE12-dist-in 9.8814 APE11-dist-in 11.9887 APE10-dist-in 6.4694 APE9-dist-in 3.5414 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.0 0.177 0.22 A 297.0 288.0 8 30 26 4 [[183, 456]] 1.0 6n8g TKL_IRAK4_HUMAN TKL 3.9e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6N8GC Q9NWZ3 164 459 460.0 KFD:501 Type1 Active DFGin 6.674 13.7674 BLAminus -132.63, 173.5 73.5, 89.42 -109.51, 12.57 307.44, 107.33 -58.55, -28.35 in-in in 8.8096 Saltbr-in 3.3471 HRD-in -80.2, -52.37 80.38, -6.83 in-in-in SNCiii in-in ActLoopNT-in 2.8023 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.29, 155.42 APE9-dihe-na 139.08, -169.18 APE8-dihe-in -120.47, 120.87 APE8-rot-in 299.74 APE67-dihe-in -68.05, -14.89 -52.69, -42.94 APE12-dist-in 10.023 APE11-dist-in 11.9495 APE10-dist-in 6.3533 APE9-dist-in 3.6611 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.0 0.177 0.22 C 297.0 289.0 7 30 26 4 [[183, 456]] 1.0 6n8g TKL_IRAK4_HUMAN TKL 3.9e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6N8GD Q9NWZ3 164 459 460.0 KFD:501 Type1 Active DFGin 6.8489 14.0366 BLAminus -133.11, 174.94 69.68, 87.35 -112.0, 19.02 309.42, 96.14 -69.47, -26.65 in-in in 8.4657 Saltbr-in 3.0627 HRD-in -74.85, -48.34 77.85, -6.98 in-in-in SNCiii in-in ActLoopNT-in 2.9429 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.26, 155.15 APE9-dihe-na 138.35, -169.27 APE8-dihe-in -119.34, 119.24 APE8-rot-in 303.95 APE67-dihe-in -65.64, -14.54 -58.36, -38.59 APE12-dist-in 9.773 APE11-dist-in 11.8987 APE10-dist-in 6.4105 APE9-dist-in 3.7994 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.0 0.177 0.22 D 297.0 280.0 16 30 25 5 [[183, 456]] 1.0 6n8g TKL_IRAK4_HUMAN TKL 3.9e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 7C2VA Q9NWZ3 163 459 460.0 FJ0:62001 Type1 Active DFGin 6.6176 14.2134 BLAminus -135.94, 175.42 58.24, 84.61 -104.43, 24.97 312.74, 88.43 -59.88, -37.17 in-in in 8.7453 Saltbr-in 3.002 HRD-in -74.11, -52.44 77.01, 1.32 in-in-in SNCiii in-in ActLoopNT-in 2.8156 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.63, 154.75 APE9-dihe-na 139.65, -164.04 APE8-dihe-in -119.02, 113.97 APE8-rot-in 308.25 APE67-dihe-in -69.21, -17.36 -47.12, -47.85 APE12-dist-in 10.0224 APE11-dist-in 11.7235 APE10-dist-in 6.4158 APE9-dist-in 3.9472 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.44 0.198 0.253 A 300.0 289.0 8 30 26 4 [[183, 456]] 1.0 7c2v TKL_IRAK4_HUMAN TKL 4e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 7C2VB Q9NWZ3 162 459 460.0 FJ0:62001 Type1 Active DFGin 6.6654 14.2521 BLAminus -135.26, 175.48 59.27, 84.88 -104.92, 25.84 312.32, 88.52 -63.18, -35.5 in-in in 8.6997 Saltbr-in 2.9903 HRD-in -74.07, -51.98 78.02, -1.39 in-in-in SNCiii in-in ActLoopNT-in 2.8117 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.61, 154.63 APE9-dihe-na 138.13, -164.33 APE8-dihe-in -118.3, 113.67 APE8-rot-in 307.85 APE67-dihe-in -69.26, -16.84 -48.23, -46.76 APE12-dist-in 10.0425 APE11-dist-in 11.779 APE10-dist-in 6.4215 APE9-dist-in 3.9206 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.44 0.198 0.253 B 300.0 283.0 15 30 25 5 [[183, 456]] 1.0 7c2v TKL_IRAK4_HUMAN TKL 4e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 7C2VC Q9NWZ3 164 460 460.0 FJ0:62001 Type1 Active DFGin 6.712 14.089 BLAminus -135.73, 175.29 58.82, 84.49 -103.99, 25.78 313.96, 89.54 -62.7, -36.78 in-in in 8.7629 Saltbr-in 2.9984 HRD-in -73.62, -52.52 77.93, -0.03 in-in-in SNCiii in-in ActLoopNT-in 2.8182 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.21, 152.15 APE9-dihe-na 142.56, -163.31 APE8-dihe-in -117.7, 113.89 APE8-rot-in 308.41 APE67-dihe-in -67.4, -19.19 -47.53, -47.66 APE12-dist-in 10.0468 APE11-dist-in 11.7965 APE10-dist-in 6.4267 APE9-dist-in 3.9165 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.44 0.198 0.253 C 300.0 283.0 14 30 25 5 [[183, 456]] 1.0 7c2v TKL_IRAK4_HUMAN TKL 4e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 7C2VD Q9NWZ3 164 459 460.0 FJ0:62001 Type1 Active DFGin 6.8435 13.991 BLAminus -135.79, 174.86 59.77, 84.88 -105.31, 25.28 314.76, 91.39 -66.34, -34.97 in-in in 8.5374 Saltbr-in 3.2341 HRD-in -74.76, -52.59 77.74, -0.48 in-in-in SNCiii in-in ActLoopNT-in 2.818 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.65, 153.85 APE9-dihe-na 138.77, -167.25 APE8-dihe-in -118.33, 113.46 APE8-rot-in 308.03 APE67-dihe-in -67.8, -17.81 -49.08, -46.8 APE12-dist-in 9.9954 APE11-dist-in 11.7907 APE10-dist-in 6.4908 APE9-dist-in 3.9523 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.44 0.198 0.253 D 300.0 286.0 10 30 26 4 [[183, 456]] 1.0 7c2v TKL_IRAK4_HUMAN TKL 4e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 2OICA Q9NWZ3 163 458 460.0 STU:1 Type1 Active DFGin 7.5415 14.5501 BLAminus -120.17, -157.79 43.1, 78.64 -95.77, 16.12 291.84, 81.73 -52.42, -46.68 in-in in 9.1643 Saltbr-in 2.7447 HRD-in -70.7, -51.8 81.1, -5.15 in-in-in SNCiii in-in ActLoopNT-in 2.8301 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.11, 162.72 APE9-dihe-na 127.09, -176.82 APE8-dihe-in -109.75, 123.25 APE8-rot-in 303.17 APE67-dihe-in -63.31, -16.61 -48.06, -48.45 APE12-dist-in 10.1333 APE11-dist-in 11.7238 APE10-dist-in 6.3469 APE9-dist-in 3.4459 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 A 301.0 279.0 17 30 24 6 [[183, 456]] 1.0 2oic TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 2OICB Q9NWZ3 164 459 460.0 STU:2 Type1 Active DFGin 7.3007 14.318 BLAminus -135.72, -165.01 43.24, 86.39 -100.56, 27.64 301.91, 89.45 -68.65, -40.8 in-in in 8.997 Saltbr-in 3.0216 HRD-in -70.79, -51.12 80.52, -12.66 in-in-in SNCiii in-in ActLoopNT-in 2.8485 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.84, 167.54 APE9-dihe-na 125.4, -168.64 APE8-dihe-in -121.45, 120.26 APE8-rot-in 302.84 APE67-dihe-in -66.81, -13.26 -49.44, -48.37 APE12-dist-in 10.0934 APE11-dist-in 11.7177 APE10-dist-in 6.031 APE9-dist-in 3.6867 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 B 301.0 278.0 18 30 24 6 [[183, 456]] 1.0 2oic TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 2OICD Q9NWZ3 161 459 460.0 STU:4 Type1 Active DFGin 6.9643 14.7946 BLAminus -128.12, -176.74 47.11, 78.66 -89.74, 11.31 298.87, 93.52 -54.67, -36.62 in-in in 8.7014 Saltbr-in 2.6141 HRD-in -65.25, -53.17 80.56, 0.44 in-in-in SNCiii in-in ActLoopNT-in 2.8622 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.06, 151.9 APE9-dihe-na 143.33, 177.59 APE8-dihe-in -104.02, 127.84 APE8-rot-in 302.2 APE67-dihe-in -61.5, -18.42 -54.54, -50.36 APE12-dist-in 10.5716 APE11-dist-in 11.6739 APE10-dist-in 6.1102 APE9-dist-in 3.4836 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 D 301.0 287.0 12 30 28 2 [[183, 456]] 1.0 2oic TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4XS2B Q9NWZ3 161 459 460.0 42P:501 Type1 Active DFGin 7.0765 13.8865 BLAminus -139.83, 178.8 62.52, 89.3 -111.11, 32.77 305.23, 93.71 -72.57, -32.59 in-in in 8.756 Saltbr-in 3.1307 HRD-in -65.98, -47.74 71.13, 8.5 in-in-in SNCiii in-in ActLoopNT-in 2.9047 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.99, 146.9 APE9-dihe-na 152.01, -163.09 APE8-dihe-in -121.37, 101.63 APE8-rot-in 312.25 APE67-dihe-in -59.65, -26.7 -31.84, -51.61 APE12-dist-in 10.1773 APE11-dist-in 11.5738 APE10-dist-in 6.3629 APE9-dist-in 3.9021 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.73 0.265 0.285 B 301.0 281.0 18 30 23 7 [[183, 456]] 1.0 4xs2 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4YO6B Q9NWZ3 161 459 460.0 4GD:501 Type1 Active DFGin 6.9838 14.018 BLAminus -128.18, 178.21 60.04, 83.58 -106.22, 16.8 308.81, 100.39 -62.55, -37.23 in-in in 8.3444 Saltbr-in 3.3581 HRD-in -63.56, -52.38 78.12, -4.13 in-in-in SNCiii in-in ActLoopNT-in 2.8182 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.99, 155.41 APE9-dihe-na 134.98, -169.72 APE8-dihe-in -112.68, 114.11 APE8-rot-in 315.54 APE67-dihe-in -60.97, -21.48 -39.7, -53.59 APE12-dist-in 9.9188 APE11-dist-in 11.7342 APE10-dist-in 6.2806 APE9-dist-in 3.7727 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.32 0.199 0.225 B 301.0 280.0 19 30 24 6 [[183, 456]] 1.0 4yo6 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4YP8A Q9NWZ3 164 459 460.0 4GF:501 Type1 Active DFGin 6.842 14.1629 BLAminus -130.64, 178.89 61.7, 76.88 -103.53, 25.67 310.66, 96.36 -67.74, -31.55 in-in in 8.7784 Saltbr-in 3.5486 HRD-in -57.79, -50.73 76.7, -3.88 in-in-in SNCiii in-in ActLoopNT-in 2.7748 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.21, 150.97 APE9-dihe-na 140.01, -173.97 APE8-dihe-in -103.61, 115.43 APE8-rot-in 309.9 APE67-dihe-in -66.28, -16.88 -42.43, -50.13 APE12-dist-in 10.0082 APE11-dist-in 11.614 APE10-dist-in 6.3264 APE9-dist-in 3.9176 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 A 301.0 287.0 9 30 26 4 [[183, 456]] 1.0 4yp8 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4ZTLA Q9NWZ3 165 459 460.0 4S1:501 Type1 Active DFGin 7.2485 13.3584 BLAminus -117.91, 179.25 56.88, 97.36 -119.29, 25.75 307.86, 91.56 -68.49, -33.91 in-in in 8.0261 Saltbr-in 2.7435 HRD-in -66.32, -51.9 77.7, -4.43 in-in-in SNCiii in-in ActLoopNT-in 3.0325 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.4, 151.93 APE9-dihe-na 136.96, -167.86 APE8-dihe-in -115.05, 113.79 APE8-rot-in 311.31 APE67-dihe-in -63.05, -18.96 -38.32, -54.3 APE12-dist-in 9.9062 APE11-dist-in 11.7132 APE10-dist-in 6.3075 APE9-dist-in 3.7399 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.39 0.226 0.251 A 301.0 283.0 12 30 23 7 [[183, 456]] 1.0 4ztl TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4ZTLB Q9NWZ3 165 459 460.0 4S1:501 Type1 Active DFGin 7.3657 13.505 BLAminus -117.83, 179.65 56.5, 97.62 -119.39, 25.81 307.63, 91.72 -68.25, -34.25 in-in in 8.4246 Saltbr-in 2.8595 HRD-in -65.94, -51.9 77.53, -3.95 in-in-in SNCiii in-in ActLoopNT-in 3.0208 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.04, 153.48 APE9-dihe-na 136.39, -168.5 APE8-dihe-in -114.87, 114.24 APE8-rot-in 310.51 APE67-dihe-in -62.87, -18.96 -38.44, -53.72 APE12-dist-in 9.9024 APE11-dist-in 11.6832 APE10-dist-in 6.2716 APE9-dist-in 3.725 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.39 0.226 0.251 B 301.0 272.0 23 30 24 6 [[183, 456]] 1.0 4ztl TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4ZTLC Q9NWZ3 164 460 460.0 4S1:501 Type1 Active DFGin 7.1204 13.7358 BLAminus -116.77, 179.72 56.78, 97.16 -118.74, 26.23 307.1, 91.38 -67.56, -34.29 in-in in 8.5247 Saltbr-in 3.5919 HRD-in -66.63, -52.32 77.27, -3.33 in-in-in SNCiii in-in ActLoopNT-in 2.7645 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.73, 154.17 APE9-dihe-na 136.59, -168.35 APE8-dihe-in -115.05, 114.89 APE8-rot-in 308.8 APE67-dihe-in -61.95, -19.73 -39.55, -53.38 APE12-dist-in 9.6829 APE11-dist-in 11.6786 APE10-dist-in 6.2916 APE9-dist-in 3.7394 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.39 0.226 0.251 C 301.0 285.0 12 30 26 4 [[183, 456]] 1.0 4ztl TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4ZTMA Q9NWZ3 162 459 460.0 4S2:501 Type1 Active DFGin 6.8411 14.0035 BLAminus -126.65, 176.49 62.86, 88.68 -111.82, 16.17 306.42, 93.16 -61.8, -39.01 in-in in 8.6752 Saltbr-in 3.5039 HRD-in -66.09, -48.54 74.54, -1.58 in-in-in SNCiii in-in ActLoopNT-in 2.6621 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.13, 150.6 APE9-dihe-na 137.15, -172.25 APE8-dihe-in -111.72, 110.91 APE8-rot-in 308.99 APE67-dihe-in -63.61, -18.06 -39.97, -47.58 APE12-dist-in 9.7817 APE11-dist-in 11.6895 APE10-dist-in 6.2377 APE9-dist-in 3.84 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.66 0.195 0.226 A 301.0 290.0 8 30 27 3 [[183, 456]] 1.0 4ztm TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4ZTMB Q9NWZ3 161 459 460.0 4S2:501 Type1 Active DFGin 6.949 13.8532 BLAminus -125.14, 175.8 64.22, 86.81 -111.57, 16.58 307.7, 93.22 -64.41, -38.21 in-in in 8.1073 Saltbr-in 3.2761 HRD-in -68.42, -47.04 74.05, -1.81 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.65, 151.81 APE9-dihe-na 136.32, -173.24 APE8-dihe-in -111.48, 109.87 APE8-rot-in 308.84 APE67-dihe-in -65.88, -16.61 -38.33, -48.13 APE12-dist-in 9.8545 APE11-dist-in 11.6677 APE10-dist-in 6.2266 APE9-dist-in 3.8116 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.66 0.195 0.226 B 301.0 283.0 16 30 24 6 [[183, 456]] 1.0 4ztm TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4ZTMD Q9NWZ3 164 459 460.0 4S2:501 Type1 Active DFGin 7.3251 14.0535 BLAminus -123.99, 176.44 63.13, 88.09 -113.68, 22.11 303.38, 91.55 -67.04, -38.41 in-in in 8.4641 Saltbr-in 3.3579 HRD-in -67.68, -48.45 75.88, -3.34 in-in-in SNCiii in-in ActLoopNT-in 2.6773 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.43, 151.52 APE9-dihe-na 136.49, -173.1 APE8-dihe-in -111.23, 109.28 APE8-rot-in 305.91 APE67-dihe-in -63.51, -17.43 -35.93, -49.7 APE12-dist-in 9.8849 APE11-dist-in 11.7058 APE10-dist-in 6.2608 APE9-dist-in 3.8589 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.66 0.195 0.226 D 301.0 285.0 11 30 25 5 [[183, 456]] 1.0 4ztm TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4ZTNB Q9NWZ3 161 459 460.0 4S3:501 Type1 Active DFGin 7.1545 13.7575 BLAminus -131.99, 175.82 63.87, 82.48 -105.73, 21.47 308.39, 101.43 -66.39, -41.59 in-in in 8.5507 Saltbr-in 3.2983 HRD-in -64.32, -51.43 76.6, -0.44 in-in-in SNCiii in-in ActLoopNT-in 2.7675 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.02, 158.22 APE9-dihe-na 130.01, -170.09 APE8-dihe-in -112.61, 111.91 APE8-rot-in 309.6 APE67-dihe-in -62.86, -20.33 -37.78, -52.13 APE12-dist-in 9.8586 APE11-dist-in 11.7313 APE10-dist-in 6.2358 APE9-dist-in 3.8196 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.23 0.21 0.224 B 301.0 285.0 14 30 26 4 [[183, 456]] 1.0 4ztn TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5K72A Q9NWZ3 164 458 460.0 6QY:503 Type1 Active DFGin 6.8759 14.7895 BLAminus -129.6, 174.26 62.65, 87.42 -104.23, 19.84 308.29, 101.45 -64.94, -30.93 in-in in 8.9263 Saltbr-in 3.2928 HRD-in -66.84, -51.14 79.92, -9.54 in-in-in SNCiii in-in ActLoopNT-in 2.8541 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.42, 150.12 APE9-dihe-na 136.94, -172.18 APE8-dihe-in -106.38, 111.25 APE8-rot-in 311.69 APE67-dihe-in -67.35, -18.0 -44.33, -42.84 APE12-dist-in 10.1791 APE11-dist-in 11.8759 APE10-dist-in 6.4163 APE9-dist-in 4.057 None TPO345,SEP346 TPO345,SEP346 XRAY 2.22 0.215 0.225 A 301.0 279.0 16 30 23 7 [[183, 456]] 1.0 5k72 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5K72C Q9NWZ3 164 458 460.0 6QY:501 Type1 Active DFGin 6.8592 14.8448 BLAminus -130.1, 165.54 64.05, 88.04 -103.72, 18.66 308.67, 101.27 -64.81, -28.57 in-in in 9.1235 Saltbr-in 3.0215 HRD-in -67.68, -49.88 78.27, -10.5 in-in-in SNCiii in-in ActLoopNT-in 2.8443 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.88, 146.9 APE9-dihe-na 138.11, -173.71 APE8-dihe-in -107.12, 113.22 APE8-rot-in 310.36 APE67-dihe-in -67.72, -16.57 -43.16, -46.42 APE12-dist-in 10.0365 APE11-dist-in 11.8165 APE10-dist-in 6.3526 APE9-dist-in 4.0558 None TPO345,SEP346 TPO345,SEP346 XRAY 2.22 0.215 0.225 C 301.0 279.0 16 30 23 7 [[183, 456]] 1.0 5k72 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5K72D Q9NWZ3 164 458 460.0 6QY:501 Type1 Active DFGin 6.8499 14.806 BLAminus -126.68, 172.94 63.42, 86.83 -103.81, 18.76 308.64, 101.29 -64.45, -29.98 in-in in 9.1769 Saltbr-in 3.1013 HRD-in -66.74, -50.47 78.85, -9.74 in-in-in SNCiii in-in ActLoopNT-in 2.8486 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.97, 148.93 APE9-dihe-na 136.71, -173.44 APE8-dihe-in -107.04, 113.0 APE8-rot-in 309.77 APE67-dihe-in -66.49, -17.75 -42.69, -46.95 APE12-dist-in 10.1232 APE11-dist-in 11.894 APE10-dist-in 6.3939 APE9-dist-in 3.9898 None TPO345,SEP346 TPO345,SEP346 XRAY 2.22 0.215 0.225 D 301.0 278.0 17 30 23 7 [[183, 456]] 1.0 5k72 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5K75A Q9NWZ3 164 458 460.0 6QX:501 Type1 Active DFGin 6.9609 14.4664 BLAminus -129.66, 172.88 64.37, 85.54 -104.02, 19.65 309.39, 101.24 -65.12, -32.34 in-in in 8.9961 Saltbr-in 3.3638 HRD-in -66.74, -50.79 80.27, -9.49 in-in-in SNCiii in-in ActLoopNT-in 2.8428 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.74, 147.16 APE9-dihe-na 138.19, -172.64 APE8-dihe-in -106.01, 110.67 APE8-rot-in 312.95 APE67-dihe-in -63.15, -20.46 -40.66, -48.43 APE12-dist-in 10.1694 APE11-dist-in 11.8969 APE10-dist-in 6.4602 APE9-dist-in 4.0576 None TPO345,SEP346 TPO345,SEP346 XRAY 2.03 0.24 0.253 A 301.0 273.0 22 30 22 8 [[183, 456]] 1.0 5k75 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5K76B Q9NWZ3 164 458 460.0 6R1:501 Type1 Active DFGin 6.842 14.8465 BLAminus -120.86, 179.92 54.63, 86.6 -104.85, 21.84 304.89, 98.02 -65.03, -33.77 in-in in 8.8208 Saltbr-in 3.3542 HRD-in -64.93, -47.01 74.5, -8.88 in-in-in SNCiii in-in ActLoopNT-in 2.797 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.39, 155.1 APE9-dihe-na 131.16, -171.05 APE8-dihe-in -106.73, 112.96 APE8-rot-in 313.37 APE67-dihe-in -69.81, -11.83 -40.26, -47.81 APE12-dist-in 10.0469 APE11-dist-in 11.658 APE10-dist-in 6.1477 APE9-dist-in 3.681 None TPO345,SEP346 TPO345,SEP346 XRAY 2.74 0.218 0.246 B 301.0 283.0 12 30 23 7 [[183, 456]] 1.0 5k76 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5K7GA Q9NWZ3 164 458 460.0 6R0:503 Type1 Active DFGin 6.9273 14.5789 BLAminus -130.44, 172.6 63.09, 86.67 -104.49, 18.83 308.78, 101.81 -65.52, -32.04 in-in in 8.8776 Saltbr-in 3.3007 HRD-in -67.24, -50.39 78.51, -10.38 in-in-in SNCiii in-in ActLoopNT-in 2.8499 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.81, 145.66 APE9-dihe-na 138.88, -174.27 APE8-dihe-in -106.05, 110.69 APE8-rot-in 312.32 APE67-dihe-in -63.78, -20.0 -39.72, -49.62 APE12-dist-in 10.0827 APE11-dist-in 11.8705 APE10-dist-in 6.4292 APE9-dist-in 4.12 None TPO345,SEP346 TPO345,SEP346 XRAY 2.23 0.207 0.227 A 301.0 279.0 16 30 23 7 [[183, 456]] 1.0 5k7g TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5K7GC Q9NWZ3 164 458 460.0 6R0:501 Type1 Active DFGin 6.9575 14.4653 BLAminus -132.74, 161.94 65.76, 88.06 -104.31, 18.89 309.03, 102.17 -65.27, -31.9 in-in in 8.8581 Saltbr-in 2.8923 HRD-in -66.94, -50.37 77.56, -9.09 in-in-in SNCiii in-in ActLoopNT-in 2.8541 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.84, 146.49 APE9-dihe-na 138.07, -172.84 APE8-dihe-in -106.43, 110.54 APE8-rot-in 312.48 APE67-dihe-in -63.68, -20.75 -40.38, -49.26 APE12-dist-in 10.1719 APE11-dist-in 11.746 APE10-dist-in 6.3479 APE9-dist-in 4.1262 None TPO345,SEP346 TPO345,SEP346 XRAY 2.23 0.207 0.227 C 301.0 285.0 10 30 23 7 [[183, 456]] 1.0 5k7g TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5K7GD Q9NWZ3 164 458 460.0 6R0:502 Type1 Active DFGin 6.9139 14.4521 BLAminus -130.04, 170.31 63.99, 86.8 -104.75, 18.86 309.06, 102.0 -64.76, -32.56 in-in in 8.818 Saltbr-in 3.1217 HRD-in -66.7, -50.93 78.39, -9.43 in-in-in SNCiii in-in ActLoopNT-in 2.8521 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.67, 145.96 APE9-dihe-na 138.88, -173.03 APE8-dihe-in -106.21, 110.06 APE8-rot-in 312.19 APE67-dihe-in -64.22, -19.64 -40.02, -49.24 APE12-dist-in 10.0286 APE11-dist-in 11.7906 APE10-dist-in 6.3793 APE9-dist-in 4.1312 None TPO345,SEP346 TPO345,SEP346 XRAY 2.23 0.207 0.227 D 301.0 285.0 10 30 23 7 [[183, 456]] 1.0 5k7g TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5K7IA Q9NWZ3 164 458 460.0 6QZ:501 Type1 Active DFGin 6.8482 14.706 BLAminus -122.1, 174.72 61.52, 86.0 -106.72, 22.05 309.28, 97.65 -66.92, -32.98 in-in in 8.6948 Saltbr-in 3.1305 HRD-in -68.39, -48.54 78.53, -8.67 in-in-in SNCiii in-in ActLoopNT-in 2.8118 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.35, 153.63 APE9-dihe-na 131.32, 179.82 APE8-dihe-in -93.7, 123.26 APE8-rot-in 312.64 APE67-dihe-in -64.14, -19.99 -53.75, -46.67 APE12-dist-in 10.1861 APE11-dist-in 11.8474 APE10-dist-in 6.4429 APE9-dist-in 4.0857 None TPO345,SEP346 TPO345,SEP346 XRAY 2.31 0.221 0.257 A 301.0 274.0 21 30 23 7 [[183, 456]] 1.0 5k7i TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5K7IB Q9NWZ3 164 458 460.0 6QZ:502 Type1 Active DFGin 6.8645 14.5179 BLAminus -124.19, 174.89 61.8, 86.03 -106.67, 22.39 309.0, 97.79 -67.01, -31.74 in-in in 8.7394 Saltbr-in 2.7998 HRD-in -68.08, -49.13 78.29, -7.61 in-in-in SNCiii in-in ActLoopNT-in 2.806 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.12, 153.82 APE9-dihe-na 132.9, -179.87 APE8-dihe-in -93.91, 123.35 APE8-rot-in 313.14 APE67-dihe-in -65.54, -19.28 -54.52, -46.07 APE12-dist-in 10.1598 APE11-dist-in 11.6579 APE10-dist-in 6.3434 APE9-dist-in 4.1334 None TPO345,SEP346 TPO345,SEP346 XRAY 2.31 0.221 0.257 B 301.0 273.0 22 30 23 7 [[183, 456]] 1.0 5k7i TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5KX7B Q9NWZ3 163 459 460.0 6YD:9901 Type1 Active DFGin 6.8554 13.2518 BLAminus -138.07, 174.73 58.64, 80.86 -106.82, 34.07 322.11, 87.79 -71.78, -44.9 in-in in 8.6821 Saltbr-in 3.2371 HRD-in -69.76, -47.63 72.83, 1.05 in-in-in SNCiii in-in ActLoopNT-in 2.7592 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.02, 154.26 APE9-dihe-na 136.96, -175.89 APE8-dihe-in -105.94, 108.82 APE8-rot-in 305.34 APE67-dihe-in -58.95, -17.61 -32.77, -53.96 APE12-dist-in 9.941 APE11-dist-in 11.4956 APE10-dist-in 6.1747 APE9-dist-in 3.7173 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.8 0.213 0.25 B 301.0 289.0 8 30 26 4 [[183, 456]] 1.0 5kx7 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5KX8A Q9NWZ3 163 459 460.0 6YE:501 Type1 Active DFGin 6.7791 13.4576 BLAminus -136.36, -178.34 58.1, 85.73 -110.83, 15.69 315.13, 102.91 -62.12, -34.73 in-in in 8.5225 Saltbr-in 3.3223 HRD-in -62.27, -51.5 76.44, -1.78 in-in-in SNCiii in-in ActLoopNT-in 2.6572 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.83, 147.8 APE9-dihe-na 142.35, -171.73 APE8-dihe-in -109.78, 108.72 APE8-rot-in 309.05 APE67-dihe-in -63.27, -20.61 -34.23, -50.93 APE12-dist-in 9.9822 APE11-dist-in 11.7043 APE10-dist-in 6.474 APE9-dist-in 3.9523 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.671 0.206 0.233 A 301.0 288.0 9 30 26 4 [[183, 456]] 1.0 5kx8 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5KX8B Q9NWZ3 161 459 460.0 6YE:501 Type1 Active DFGin 6.8282 13.5255 BLAminus -135.84, -178.32 58.25, 85.42 -111.0, 16.47 315.08, 103.62 -62.58, -35.26 in-in in 8.5718 Saltbr-in 2.7685 HRD-in -60.81, -51.76 76.06, -1.89 in-in-in SNCiii in-in ActLoopNT-in 2.9656 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.8, 147.8 APE9-dihe-na 142.56, -171.32 APE8-dihe-in -109.67, 108.54 APE8-rot-in 308.6 APE67-dihe-in -62.57, -21.11 -33.86, -51.07 APE12-dist-in 9.7078 APE11-dist-in 11.7045 APE10-dist-in 6.4667 APE9-dist-in 3.945 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.671 0.206 0.233 B 301.0 281.0 18 30 24 6 [[183, 456]] 1.0 5kx8 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5KX8D Q9NWZ3 164 459 460.0 6YE:501 Type1 Active DFGin 6.8858 13.4854 BLAminus -135.91, -178.68 58.98, 85.41 -110.88, 16.35 315.61, 103.98 -63.33, -34.97 in-in in 8.1882 Saltbr-in 3.2202 HRD-in -64.45, -52.27 77.75, -2.01 in-in-in SNCiii in-in ActLoopNT-in 2.6653 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.53, 147.84 APE9-dihe-na 141.85, -171.68 APE8-dihe-in -109.93, 107.97 APE8-rot-in 309.23 APE67-dihe-in -62.28, -20.43 -33.87, -50.84 APE12-dist-in 10.0055 APE11-dist-in 11.708 APE10-dist-in 6.4759 APE9-dist-in 3.9673 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.671 0.206 0.233 D 301.0 286.0 10 30 25 5 [[183, 456]] 1.0 5kx8 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5T1SD Q9NWZ3 164 459 460.0 76Q:9901 Type1 Active DFGin 6.951 14.2485 BLAminus -130.82, 172.71 63.6, 85.49 -103.7, 19.85 304.96, 98.34 -62.88, -38.58 in-in in 8.7924 Saltbr-in 3.1253 HRD-in -67.81, -51.47 79.11, -4.9 in-in-in SNCiii in-in ActLoopNT-in 2.7702 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.3, 155.38 APE9-dihe-na 137.43, -168.44 APE8-dihe-in -112.84, 114.02 APE8-rot-in 311.54 APE67-dihe-in -62.52, -17.13 -40.93, -51.81 APE12-dist-in 9.9302 APE11-dist-in 11.6365 APE10-dist-in 6.235 APE9-dist-in 3.7867 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.207 0.223 D 301.0 284.0 12 30 25 5 [[183, 456]] 1.0 5t1s TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4Y73D Q9NWZ3 164 459 460.0 XPY:1000 Type1 Active DFGin 6.9462 13.9421 BLAminus -134.48, 179.63 58.03, 76.69 -96.29, 18.79 309.44, 97.62 -57.19, -32.63 in-in in 8.8874 Saltbr-in 3.1833 HRD-in -69.87, -49.37 75.0, -4.9 in-in-in SNCiii in-in ActLoopNT-in 2.7499 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.55, 154.63 APE9-dihe-na 135.98, -173.49 APE8-dihe-in -109.02, 111.96 APE8-rot-in 310.2 APE67-dihe-in -59.31, -19.91 -40.37, -53.91 APE12-dist-in 10.0238 APE11-dist-in 11.7099 APE10-dist-in 6.3725 APE9-dist-in 4.0774 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.14 0.196 0.217 D 302.0 291.0 5 30 25 5 [[183, 456]] 1.0 4y73 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6MOMA Q9NWZ3 164 460 460.0 JX4:500 Type1 Active DFGin 7.1288 13.3417 BLAminus -133.95, 172.65 70.74, 82.36 -107.03, 19.92 305.8, 92.98 -64.41, -27.6 in-in in 8.2554 Saltbr-in 3.009 HRD-in -79.36, -51.43 75.47, 2.41 in-in-in SNCiii in-in ActLoopNT-in 2.7127 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.06, 152.26 APE9-dihe-na 137.43, -179.57 APE8-dihe-in -101.68, 120.01 APE8-rot-in 303.6 APE67-dihe-in -63.77, -14.43 -53.86, -42.85 APE12-dist-in 10.3433 APE11-dist-in 12.1388 APE10-dist-in 7.3018 APE9-dist-in 4.7914 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.168 0.207 A 303.0 289.0 8 30 27 3 [[183, 456]] 1.0 6mom TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6MOMC Q9NWZ3 163 460 460.0 JX4:500 Type1 Active DFGin 7.1322 13.3299 BLAminus -133.27, 172.2 69.98, 81.72 -106.08, 16.49 303.99, 96.21 -63.79, -25.79 in-in in 8.2366 Saltbr-in 2.78 HRD-in -77.9, -50.77 76.54, 1.38 in-in-in SNCiii in-in ActLoopNT-in 2.7171 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.08, 151.25 APE9-dihe-na 135.21, -179.82 APE8-dihe-in -101.82, 118.78 APE8-rot-in 306.47 APE67-dihe-in -63.2, -15.41 -53.95, -41.15 APE12-dist-in 10.3567 APE11-dist-in 12.0705 APE10-dist-in 7.0672 APE9-dist-in 4.647 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.168 0.207 C 303.0 292.0 6 30 27 3 [[183, 456]] 1.0 6mom TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 9NA3A Q9NWZ3 164 458 460.0 A1BWX:501 Type1 Active DFGin 6.752 13.8599 BLAminus -133.1, 172.88 66.49, 85.44 -111.24, 22.95 310.94, 83.55 -69.24, -28.75 in-in in 8.6045 Saltbr-in 3.0051 HRD-in -73.29, -51.42 75.45, 6.3 in-in-in SNCiii in-in ActLoopNT-in 2.9071 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.49, 152.01 APE9-dihe-na 139.45, -179.34 APE8-dihe-in -101.95, 112.38 APE8-rot-in 313.22 APE67-dihe-in -64.69, -17.61 -61.03, -33.08 APE12-dist-in 9.927 APE11-dist-in 11.7302 APE10-dist-in 6.4552 APE9-dist-in 4.2549 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.245 0.277 A 304.0 284.0 11 30 25 5 [[183, 456]] 1.0 9na3 TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 9NA3H0A0 Q9NWZ3 164 459 460.0 A1BWX:501 Type1 Active DFGin 6.5887 14.4287 BLAminus -128.39, 175.47 61.09, 89.59 -111.86, 22.39 307.69, 91.01 -72.62, -22.45 in-in in 9.0451 Saltbr-in 3.1983 HRD-in -69.35, -50.66 74.83, 1.0 in-in-in SNCiii in-in ActLoopNT-in 2.7258 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.08, 148.29 APE9-dihe-na 138.75, -172.51 APE8-dihe-in -111.34, 119.79 APE8-rot-in 307.77 APE67-dihe-in -65.4, -14.21 -55.78, -41.76 APE12-dist-in 9.9985 APE11-dist-in 11.593 APE10-dist-in 6.0692 APE9-dist-in 4.0699 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.245 0.277 H0A0 304.0 277.0 19 30 25 5 [[183, 456]] 1.0 9na3 TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 9NA4A Q9NWZ3 164 459 460.0 A1BW1:501 Type1 Active DFGin 6.8128 14.3101 BLAminus -127.38, -174.41 53.31, 76.49 -96.02, 23.68 303.26, 85.02 -73.65, -19.1 in-in in 8.8284 Saltbr-in 2.8811 HRD-in -71.63, -47.62 74.26, 11.21 in-in-in SNCiii in-in ActLoopNT-in 2.7297 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.51, 136.05 APE9-dihe-na 160.84, -170.21 APE8-dihe-in -108.63, 109.57 APE8-rot-in 307.2 APE67-dihe-in -69.94, -9.11 -50.47, -38.9 APE12-dist-in 9.7732 APE11-dist-in 11.7326 APE10-dist-in 6.7006 APE9-dist-in 4.1292 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.33 0.227 0.273 A 304.0 283.0 13 30 25 5 [[183, 456]] 1.0 9na4 TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 9NA4B Q9NWZ3 164 459 460.0 A1BW1:501 Type1 Active DFGin 6.8953 14.2573 BLAminus -128.47, -178.23 58.06, 81.63 -102.84, 25.74 297.67, 81.88 -71.22, -28.21 in-in in 8.905 Saltbr-in 3.1288 HRD-in -72.71, -43.84 74.71, -2.67 in-in-in SNCiii in-in ActLoopNT-in 2.7416 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.53, 162.66 APE9-dihe-na 130.06, -172.53 APE8-dihe-in -106.79, 115.27 APE8-rot-in 294.12 APE67-dihe-in -66.46, -17.91 -59.45, -33.75 APE12-dist-in 9.8798 APE11-dist-in 11.3984 APE10-dist-in 6.504 APE9-dist-in 4.2936 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.33 0.227 0.273 B 304.0 283.0 13 30 25 5 [[183, 456]] 1.0 9na4 TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 9NA4C Q9NWZ3 164 459 460.0 A1BW1:501 Type1 Active DFGin 6.8619 13.9119 BLAminus -133.2, 178.13 56.03, 83.33 -103.05, 20.53 303.74, 87.67 -66.4, -20.44 in-in in 8.9563 Saltbr-in 2.982 HRD-in -79.23, -52.87 78.53, 5.04 in-in-in SNCiii in-in ActLoopNT-in 2.7295 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.71, 151.98 APE9-dihe-na 136.82, -178.5 APE8-dihe-in -102.72, 112.21 APE8-rot-in 308.82 APE67-dihe-in -65.51, -14.62 -58.09, -34.11 APE12-dist-in 10.1177 APE11-dist-in 11.7744 APE10-dist-in 6.7322 APE9-dist-in 4.3722 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.33 0.227 0.273 C 304.0 285.0 11 30 25 5 [[183, 456]] 1.0 9na4 TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 9NA4D Q9NWZ3 165 459 460.0 A1BW1:501 Type1 Active DFGin 6.9821 14.1652 BLAminus -128.79, -176.45 53.3, 89.86 -110.92, 19.74 296.14, 90.51 -74.91, -26.5 in-in in 8.9318 Saltbr-in 2.6587 HRD-in -78.81, -47.02 77.11, -5.8 in-in-in SNCiii in-in ActLoopNT-in 2.7715 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.58, 166.79 APE9-dihe-na 117.7, -160.99 APE8-dihe-in -116.5, 117.73 APE8-rot-in 325.76 APE67-dihe-in -62.89, -19.72 -54.11, -37.62 APE12-dist-in 10.066 APE11-dist-in 11.5289 APE10-dist-in 6.5058 APE9-dist-in 4.3708 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.33 0.227 0.273 D 304.0 284.0 11 30 25 5 [[183, 456]] 1.0 9na4 TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5W84A Q9NWZ3 165 459 460.0 9YY:4000 Type1 Active DFGin 7.2908 14.7392 BLAminus -116.66, -177.09 50.05, 80.29 -103.22, 13.06 304.5, 91.12 -69.66, -13.48 in-in in 8.6947 Saltbr-in 3.1553 HRD-in -58.29, -49.11 72.64, 6.83 in-in-in SNCiii in-in ActLoopNT-in 2.7779 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.65, 156.49 APE9-dihe-na 134.34, -164.03 APE8-dihe-in -112.68, 108.44 APE8-rot-in 309.9 APE67-dihe-inflip 85.12, -33.46 -56.68, 166.21 APE12-dist-in 10.3832 APE11-dist-in 11.9942 APE10-dist-in 6.7579 APE9-dist-in 3.6777 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.9 0.202 0.248 A 305.0 282.0 13 30 25 5 [[183, 456]] 1.0 5w84 TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8SCEB Q9NWZ3 164 458 460.0 ZVD:501 Type1 Active DFGin 6.8725 13.8448 BLAminus -128.59, -178.77 60.92, 81.27 -102.45, 15.1 307.63, 100.59 -60.68, -32.26 in-in in 8.6415 Saltbr-in 3.2068 HRD-in -69.44, -52.46 77.81, -3.32 in-in-in SNCiii in-in ActLoopNT-in 2.7901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.77, 152.58 APE9-dihe-na 139.09, -170.98 APE8-dihe-in -109.95, 109.6 APE8-rot-in 309.72 APE67-dihe-in -61.76, -17.48 -53.14, -40.37 APE12-dist-in 10.5158 APE11-dist-in 11.7603 APE10-dist-in 6.561 APE9-dist-in 4.2252 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.89 0.204 0.228 B 305.0 287.0 8 30 25 5 [[183, 456]] 1.0 8sce TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8SCED Q9NWZ3 161 459 460.0 ZVD:502 Type1 Active DFGin 6.7762 13.9041 BLAminus -121.43, -179.64 62.94, 81.94 -102.76, 13.61 305.86, 101.34 -60.3, -31.77 in-in in 8.6314 Saltbr-in 3.283 HRD-in -70.01, -51.91 77.74, -5.02 in-in-in SNCiii in-in ActLoopNT-in 2.7748 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.26, 152.99 APE9-dihe-na 137.91, -170.79 APE8-dihe-in -110.55, 110.46 APE8-rot-in 310.04 APE67-dihe-in -60.43, -17.98 -47.93, -46.75 APE12-dist-in 10.4381 APE11-dist-in 11.9081 APE10-dist-in 6.6649 APE9-dist-in 4.244 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.89 0.204 0.228 D 305.0 289.0 10 30 26 4 [[183, 456]] 1.0 8sce TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8SCEE Q9NWZ3 162 459 460.0 ZVD:503 Type1 Active DFGin 6.8879 13.9235 BLAminus -126.97, -179.73 60.71, 81.73 -102.64, 14.04 307.26, 101.4 -57.91, -39.49 in-in in 8.6754 Saltbr-in 3.5345 HRD-in -70.01, -51.05 77.24, -5.5 in-in-in SNCiii in-in ActLoopNT-in 2.7794 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.13, 152.08 APE9-dihe-na 138.21, -170.74 APE8-dihe-in -110.91, 109.01 APE8-rot-in 310.79 APE67-dihe-in -61.86, -16.65 -47.33, -46.49 APE12-dist-in 10.5153 APE11-dist-in 11.9011 APE10-dist-in 6.6318 APE9-dist-in 4.2245 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.89 0.204 0.228 E 305.0 285.0 13 30 26 4 [[183, 456]] 1.0 8sce TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8SCVA Q9NWZ3 163 458 460.0 ZVG:501 Type1 Active DFGin 7.184 13.9863 BLAminus -124.46, -179.76 59.49, 87.11 -109.26, 17.19 305.43, 95.33 -61.37, -28.15 in-in in 8.6029 Saltbr-in 2.786 HRD-in -70.57, -45.98 74.49, -10.35 in-in-in SNCiii in-in ActLoopNT-in 2.7225 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.75, 138.68 APE9-dihe-na 145.66, -163.91 APE8-dihe-in -109.56, 109.15 APE8-rot-in 316.1 APE67-dihe-in -55.77, -25.63 -52.88, -41.01 APE12-dist-in 11.5674 APE11-dist-in 11.7092 APE10-dist-in 6.5021 APE9-dist-in 4.3107 None SEP284,TPO345,SEP346 SEP284,TPO345,SEP346 XRAY 2.69 0.222 0.261 A 305.0 290.0 6 30 26 4 [[183, 456]] 1.0 8scv TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8SCWA Q9NWZ3 164 458 460.0 ZVA:502 Type1 Active DFGin 6.949 13.9554 BLAminus -127.98, -178.64 58.18, 81.05 -102.57, 16.55 304.99, 101.16 -62.35, -27.98 in-in in 8.6228 Saltbr-in 3.0695 HRD-in -64.77, -51.29 78.36, -5.77 in-in-in SNCiii in-in ActLoopNT-in 2.783 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.58, 147.29 APE9-dihe-na 136.17, -170.2 APE8-dihe-in -107.72, 107.21 APE8-rot-in 307.44 APE67-dihe-in -62.81, -21.07 -41.99, -38.76 APE12-dist-in 10.2887 APE11-dist-in 11.803 APE10-dist-in 6.5358 APE9-dist-in 4.1925 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.76 0.197 0.238 A 305.0 286.0 9 30 25 5 [[183, 456]] 1.0 8scw TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8SCWB Q9NWZ3 164 458 460.0 ZVA:503 Type1 Active DFGin 6.9168 13.9346 BLAminus -128.2, -178.62 57.88, 81.14 -102.7, 16.27 305.4, 99.65 -62.0, -27.36 in-in in 8.6796 Saltbr-in 3.1049 HRD-in -66.25, -47.62 74.19, -3.24 in-in-in SNCiii in-in ActLoopNT-in 2.8495 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.99, 148.79 APE9-dihe-na 138.79, -168.97 APE8-dihe-in -106.05, 107.42 APE8-rot-in 307.69 APE67-dihe-in -61.91, -21.89 -43.06, -38.9 APE12-dist-in 10.1493 APE11-dist-in 11.6777 APE10-dist-in 6.4467 APE9-dist-in 4.1736 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.76 0.197 0.238 B 305.0 286.0 9 30 25 5 [[183, 456]] 1.0 8scw TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8SCWC Q9NWZ3 164 458 460.0 ZVA:504 Type1 Active DFGin 6.9904 13.9574 BLAminus -128.34, -178.84 58.46, 80.95 -102.7, 17.0 305.11, 100.34 -60.28, -38.49 in-in in 8.6123 Saltbr-in 3.0779 HRD-in -64.94, -50.47 78.38, -7.14 in-in-in SNCiii in-in ActLoopNT-in 2.7877 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.26, 147.61 APE9-dihe-na 135.64, -170.98 APE8-dihe-in -106.84, 106.55 APE8-rot-in 307.9 APE67-dihe-in -62.95, -20.83 -41.66, -39.27 APE12-dist-in 10.2813 APE11-dist-in 11.9023 APE10-dist-in 6.5798 APE9-dist-in 4.1563 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.76 0.197 0.238 C 305.0 284.0 11 30 24 6 [[183, 456]] 1.0 8scw TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8SCWD Q9NWZ3 164 458 460.0 ZVA:503 Type1 Active DFGin 6.9301 13.9264 BLAminus -127.14, -178.48 58.45, 80.61 -102.69, 16.54 304.74, 100.68 -62.23, -29.15 in-in in 8.5743 Saltbr-in 3.051 HRD-in -64.31, -51.28 79.3, -9.6 in-in-in SNCiii in-in ActLoopNT-in 2.7763 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.27, 148.51 APE9-dihe-na 135.19, -171.01 APE8-dihe-in -107.16, 107.03 APE8-rot-in 307.56 APE67-dihe-in -62.12, -22.03 -41.61, -38.47 APE12-dist-in 10.2513 APE11-dist-in 11.8888 APE10-dist-in 6.5736 APE9-dist-in 4.1593 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.76 0.197 0.238 D 305.0 284.0 11 30 24 6 [[183, 456]] 1.0 8scw TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 2NRYC Q9NWZ3 164 458 460.0 STU:503 Type1 Active DFGin 7.3959 13.9911 BLAminus -129.87, 177.33 66.53, 79.75 -106.36, 3.08 302.75, 99.86 -41.96, -44.4 in-in in 9.0503 Saltbr-in 2.876 HRD-in -69.99, -46.9 74.7, -3.92 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.06, 166.37 APE9-dihe-na 122.8, -162.09 APE8-dihe-in -122.72, 120.05 APE8-rot-in 297.38 APE67-dihe-in -61.23, -20.14 -50.62, -47.6 APE12-dist-in 11.8451 APE11-dist-in 12.224 APE10-dist-in 6.9995 APE9-dist-in 3.8635 None TPO345 TPO345 XRAY 2.15 0.212 0.261 C 307.0 281.0 14 30 26 4 [[183, 456]] 1.0 2nry TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 2NRYD Q9NWZ3 164 460 460.0 STU:501 Type1 Active DFGin 7.1034 14.6012 BLAminus -126.69, 167.35 70.82, 64.69 -93.05, 43.05 345.42, 126.85 -89.85, -18.2 in-in in 9.1762 Saltbr-in 2.9498 HRD-in -59.6, -55.9 83.92, -5.49 in-in-in SNCiii in-in ActLoopNT-in 2.7235 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.15, 176.95 APE9-dihe-na 112.24, -167.34 APE8-dihe-in -128.61, 119.15 APE8-rot-in 302.8 APE67-dihe-in -66.3, -17.75 -48.9, -47.71 APE12-dist-in 10.0254 APE11-dist-in 11.6148 APE10-dist-in 6.2715 APE9-dist-in 3.5382 None TPO345 TPO345 XRAY 2.15 0.212 0.261 D 307.0 283.0 14 30 25 5 [[183, 456]] 1.0 2nry TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8TVMB Q9NWZ3 164 459 460.0 VDC:501 Type1 Active DFGin 6.7569 13.5478 BLAminus -140.59, 174.72 61.77, 69.23 -90.22, 25.09 318.9, 80.9 -70.23, -27.26 in-in in 8.9524 Saltbr-in 3.5122 HRD-in -71.78, -55.46 78.6, -2.38 in-in-in SNCiii in-in ActLoopNT-in 2.898 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.68, 151.46 APE9-dihe-na 150.0, -172.63 APE8-dihe-in -105.17, 113.19 APE8-rot-in 324.78 APE67-dihe-in -64.51, -17.83 -60.0, -33.31 APE12-dist-in 10.1836 APE11-dist-in 11.6186 APE10-dist-in 6.722 APE9-dist-in 4.1456 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.223 0.246 B 307.0 289.0 7 30 25 5 [[183, 456]] 1.0 8tvm TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8TVNA Q9NWZ3 167 459 460.0 VE9:501 Type1 Active DFGin 6.8013 14.5814 BLAminus -129.9, -179.17 62.87, 70.82 -90.97, 13.68 296.57, 88.9 -64.15, -18.87 in-in in 8.9586 Saltbr-in 3.5257 HRD-in -70.68, -50.01 73.53, -1.21 in-in-in SNCiii in-in ActLoopNT-in 2.8215 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.33, 162.7 APE9-dihe-na 136.65, 178.35 APE8-dihe-in -105.63, 112.36 APE8-rot-in 304.38 APE67-dihe-in -66.2, -13.47 -50.45, -42.66 APE12-dist-in 10.2672 APE11-dist-in 11.4969 APE10-dist-in 6.0672 APE9-dist-in 3.5946 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.95 0.208 0.242 A 307.0 282.0 11 30 24 6 [[183, 456]] 1.0 8tvn TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6THXA Q9NWZ3 164 458 460.0 N9Z:501 Type1 Active DFGin 6.5269 14.5293 BLAminus -127.56, 172.71 65.6, 83.21 -103.86, 30.76 312.6, 124.02 -71.9, -39.12 in-in in 8.4488 Saltbr-in 3.1272 HRD-in -68.51, -52.67 79.87, -7.09 in-in-in SNCiii in-in ActLoopNT-in 2.7729 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.98, 146.03 APE9-dihe-na 147.06, -173.06 APE8-dihe-in -104.96, 109.73 APE8-rot-in 309.29 APE67-dihe-in -62.88, -17.94 -53.78, -36.75 APE12-dist-in 10.1457 APE11-dist-in 11.8181 APE10-dist-in 6.4566 APE9-dist-in 4.0718 None TPO345,SEP346 TPO345,SEP346 XRAY 1.99 0.232 0.254 A 308.0 279.0 16 30 24 6 [[183, 456]] 1.0 6thx TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6THZA Q9NWZ3 165 458 460.0 NB5:501 Type1 Active DFGin 7.0352 14.6174 BLAminus -132.59, 174.22 64.51, 87.68 -105.41, 12.97 302.18, 105.06 -60.16, -39.11 in-in in 8.7311 Saltbr-in 3.5149 HRD-in -71.52, -47.24 73.49, 0.54 in-in-in SNCiii in-in ActLoopNT-in 2.7941 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.0, 149.74 APE9-dihe-na 142.66, -166.48 APE8-dihe-in -108.46, 106.97 APE8-rot-in 312.32 APE67-dihe-in -65.37, -19.1 -35.78, -49.68 APE12-dist-in 10.562 APE11-dist-in 12.0194 APE10-dist-in 6.8127 APE9-dist-in 4.1097 None TPO345,SEP346 TPO345,SEP346 XRAY 2.38 0.233 0.274 A 308.0 267.0 27 30 24 6 [[183, 456]] 1.0 6thz TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6TI8A Q9NWZ3 165 459 460.0 NBW:501 Type1 Active DFGin 6.4958 14.6874 BLAminus -132.22, 174.78 65.5, 84.55 -108.45, 28.29 312.44, 86.03 -64.97, -26.16 in-in in 8.3272 Saltbr-in 3.3681 HRD-in -64.49, -50.7 73.68, -1.41 in-in-in SNCiii in-in ActLoopNT-in 2.811 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.02, 143.49 APE9-dihe-na 153.75, -168.62 APE8-dihe-in -108.33, 109.09 APE8-rot-in 310.4 APE67-dihe-in -69.46, -9.13 -46.33, -44.33 APE12-dist-in 10.5795 APE11-dist-in 11.6962 APE10-dist-in 6.6386 APE9-dist-in 4.027 None TPO345,SEP346 TPO345,SEP346 XRAY 2.32 0.25 0.281 A 308.0 284.0 11 30 24 6 [[183, 456]] 1.0 6ti8 TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6TI8B Q9NWZ3 165 459 460.0 NBW:501 Type1 Active DFGin 6.8303 14.8598 BLAminus -122.99, 177.68 58.9, 84.31 -102.33, 16.41 302.19, 94.44 -63.27, -32.27 in-in in 8.5736 Saltbr-in 2.9774 HRD-in -64.71, -50.68 74.15, -2.22 in-in-in SNCiii in-in ActLoopNT-in 2.8108 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.3, 142.5 APE9-dihe-na 153.81, -169.31 APE8-dihe-in -108.96, 109.53 APE8-rot-in 310.52 APE67-dihe-in -69.44, -9.65 -46.25, -44.57 APE12-dist-in 10.5598 APE11-dist-in 11.7446 APE10-dist-in 6.6717 APE9-dist-in 4.0381 None TPO345,SEP346 TPO345,SEP346 XRAY 2.32 0.25 0.281 B 308.0 282.0 13 30 23 7 [[183, 456]] 1.0 6ti8 TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6TI8C Q9NWZ3 164 459 460.0 NBW:501 Type1 Active DFGin 6.6548 14.4556 BLAminus -124.84, 176.47 59.94, 83.94 -103.8, 22.42 311.19, 97.24 -66.26, -29.87 in-in in 8.6414 Saltbr-in 2.8322 HRD-in -65.72, -50.02 73.46, -0.5 in-in-in SNCiii in-in ActLoopNT-in 2.8056 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.4, 142.09 APE9-dihe-na 155.32, -168.59 APE8-dihe-in -109.34, 108.99 APE8-rot-in 310.65 APE67-dihe-in -68.15, -9.66 -46.14, -45.0 APE12-dist-in 10.5162 APE11-dist-in 11.6096 APE10-dist-in 6.577 APE9-dist-in 4.0295 None TPO345,SEP346 TPO345,SEP346 XRAY 2.32 0.25 0.281 C 308.0 285.0 11 30 23 7 [[183, 456]] 1.0 6ti8 TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6TI8D Q9NWZ3 164 458 460.0 NBW:501 Type1 Active DFGin 6.6646 14.2723 BLAminus -125.76, 177.59 59.54, 84.07 -104.02, 21.13 313.62, 95.57 -66.12, -29.76 in-in in 8.6145 Saltbr-in 3.0599 HRD-in -64.51, -50.99 73.54, -1.12 in-in-in SNCiii in-in ActLoopNT-in 2.803 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.51, 142.91 APE9-dihe-na 153.9, -168.19 APE8-dihe-in -108.74, 108.12 APE8-rot-in 312.3 APE67-dihe-in -68.08, -10.4 -45.75, -44.97 APE12-dist-in 10.5281 APE11-dist-in 11.6616 APE10-dist-in 6.6114 APE9-dist-in 4.0361 None TPO345,SEP346 TPO345,SEP346 XRAY 2.32 0.25 0.281 D 308.0 284.0 11 30 23 7 [[183, 456]] 1.0 6ti8 TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 7QG3A Q9NWZ3 164 458 460.0 B4U:501 Type1 Active DFGin 6.9181 15.1287 BLAminus -118.63, 175.18 58.47, 100.85 -117.38, 18.69 296.79, 96.31 -62.72, -22.67 in-in in 8.5187 Saltbr-in 2.81 HRD-in -67.79, -50.6 77.88, -8.47 in-in-in SNCiii in-in ActLoopNT-in 2.7837 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.78, 143.14 APE9-dihe-na 150.68, -166.83 APE8-dihe-in -109.63, 113.48 APE8-rot-in 315.93 APE67-dihe-in -63.55, -19.13 -55.1, -38.42 APE12-dist-in 10.8649 APE11-dist-in 11.7855 APE10-dist-in 6.7056 APE9-dist-in 4.2432 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.11 0.273 0.304 A 308.0 278.0 17 30 24 6 [[183, 456]] 1.0 7qg3 TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 9R9JA Q9NWZ3 161 458 460.0 A1JDR:501 Type1 Active DFGin 6.8659 14.3463 BLAminus -129.25, 179.93 58.23, 81.1 -101.74, 30.63 308.21, 100.29 -70.86, -33.46 in-in in 8.2604 Saltbr-in 2.7897 HRD-in -63.31, -48.65 74.54, -3.02 in-in-in SNCiii in-in ActLoopNT-in 2.7549 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.24, 156.68 APE9-dihe-na 136.68, -172.42 APE8-dihe-in -113.58, 112.35 APE8-rot-in 310.23 APE67-dihe-in -62.74, -18.52 -46.74, -43.52 APE12-dist-in 10.2203 APE11-dist-in 11.4894 APE10-dist-in 5.9896 APE9-dist-in 3.6231 None TPO345,SEP346 TPO345,SEP346 XRAY 2.39 0.223 0.263 A 308.0 286.0 12 30 26 4 [[183, 456]] 1.0 9r9j TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 9R9JB Q9NWZ3 161 458 460.0 A1JDR:501 Type1 Active DFGin 6.8465 14.6405 BLAminus -131.61, -178.04 51.54, 84.54 -96.41, 15.7 297.09, 102.18 -62.93, -32.93 in-in in 8.5012 Saltbr-in 2.6937 HRD-in -63.37, -52.47 76.18, 0.48 in-in-in SNCiii in-in ActLoopNT-in 2.8344 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.52, 156.28 APE9-dihe-na 136.33, -173.58 APE8-dihe-in -113.86, 111.72 APE8-rot-in 311.39 APE67-dihe-in -61.96, -19.34 -42.6, -47.27 APE12-dist-in 10.2039 APE11-dist-in 11.5149 APE10-dist-in 6.0235 APE9-dist-in 3.5595 None TPO345,SEP346 TPO345,SEP346 XRAY 2.39 0.223 0.263 B 308.0 288.0 10 30 26 4 [[183, 456]] 1.0 9r9j TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 9R9JC Q9NWZ3 164 458 460.0 A1JDR:501 Type1 Active DFGin 7.0778 14.5939 BLAminus -129.42, 175.26 60.25, 82.4 -97.97, 19.86 302.57, 101.34 -61.97, -34.27 in-in in 8.4059 Saltbr-in 2.7486 HRD-in -64.97, -49.19 74.55, -3.37 in-in-in SNCiii in-in ActLoopNT-in 2.8463 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.64, 156.94 APE9-dihe-na 136.07, -170.81 APE8-dihe-in -114.95, 112.8 APE8-rot-in 308.93 APE67-dihe-in -61.09, -18.92 -46.93, -44.09 APE12-dist-in 10.1321 APE11-dist-in 11.497 APE10-dist-in 6.0134 APE9-dist-in 3.654 None TPO345,SEP346 TPO345,SEP346 XRAY 2.39 0.223 0.263 C 308.0 286.0 9 30 26 4 [[183, 456]] 1.0 9r9j TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 9R9JD Q9NWZ3 164 458 460.0 A1JDR:501 Type1 Active DFGin 6.7491 14.2965 BLAminus -130.45, 174.51 61.25, 83.64 -101.39, 23.57 312.6, 100.72 -63.42, -32.89 in-in in 8.4166 Saltbr-in 2.754 HRD-in -65.01, -48.51 74.63, -4.34 in-in-in SNCiii in-in ActLoopNT-in 2.7552 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.48, 154.74 APE9-dihe-na 136.0, -172.13 APE8-dihe-in -115.41, 112.47 APE8-rot-in 309.74 APE67-dihe-in -62.04, -18.44 -44.31, -45.7 APE12-dist-in 10.3119 APE11-dist-in 11.6086 APE10-dist-in 6.0691 APE9-dist-in 3.6424 None TPO345,SEP346 TPO345,SEP346 XRAY 2.39 0.223 0.263 D 308.0 281.0 14 30 25 5 [[183, 456]] 1.0 9r9j TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 9R9KA Q9NWZ3 162 460 460.0 A1JDQ:501 Type1 Active DFGin 6.9262 14.0839 BLAminus -126.64, 177.21 56.19, 79.08 -95.18, 26.45 305.03, 89.52 -65.57, -28.51 in-in in 8.9061 Saltbr-in 3.1673 HRD-in -66.88, -49.66 78.32, -6.79 in-in-in SNCiii in-in ActLoopNT-in 2.8729 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.84, 161.94 APE9-dihe-na 133.27, -170.49 APE8-dihe-in -114.57, 114.37 APE8-rot-in 305.97 APE67-dihe-in -63.05, -13.23 -41.26, -51.52 APE12-dist-in 10.1327 APE11-dist-in 11.553 APE10-dist-in 6.1785 APE9-dist-in 3.6673 None TPO345,SEP346 TPO345,SEP346 XRAY 1.87 0.216 0.242 A 308.0 286.0 13 30 23 7 [[183, 456]] 1.0 9r9k TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 9R9KB Q9NWZ3 158 460 460.0 A1JDQ:501 Type1 Active DFGin 7.054 14.0094 BLAminus -121.37, 179.62 54.87, 78.76 -94.27, 23.12 304.61, 89.05 -66.48, -26.41 in-in in 9.139 Saltbr-in 3.5739 HRD-in -67.81, -49.8 79.17, -8.08 in-in-in SNCiii in-in ActLoopNT-in 2.8783 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.42, 161.33 APE9-dihe-na 132.97, -172.93 APE8-dihe-in -114.32, 113.72 APE8-rot-in 306.88 APE67-dihe-in -62.56, -13.28 -40.03, -52.35 APE12-dist-in 10.1603 APE11-dist-in 11.5171 APE10-dist-in 6.1401 APE9-dist-in 3.7276 None TPO345,SEP346 TPO345,SEP346 XRAY 1.87 0.216 0.242 B 308.0 290.0 13 30 23 7 [[183, 456]] 1.0 9r9k TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6O9DC Q9NWZ3 163 458 460.0 LTY:501 Type1 Active DFGin 6.9212 14.0549 BLAminus -144.04, 172.46 65.41, 89.1 -109.46, 16.79 309.79, 96.88 -60.57, -25.46 in-in in 8.6382 Saltbr-in 3.2434 HRD-in -67.13, -59.39 84.36, 2.8 in-in-in SNCiii in-in ActLoopNT-in 2.9172 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.08, 166.4 APE9-dihe-na 121.39, -170.65 APE8-dihe-in -111.39, 114.64 APE8-rot-in 323.79 APE67-dihe-in -65.1, -19.0 -57.03, -32.94 APE12-dist-in 10.0662 APE11-dist-in 11.8362 APE10-dist-in 6.5389 APE9-dist-in 4.0321 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.51 0.197 0.239 C 320.0 283.0 13 30 25 5 [[183, 456]] 1.0 6o9d TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6UYAC Q9NWZ3 162 458 460.0 QL7:501 Type1 Active DFGin 6.469 14.031 BLAminus -122.12, 175.34 66.82, 92.98 -113.93, 10.94 305.64, 93.58 -60.94, -31.46 in-in in 8.6103 Saltbr-in 3.4686 HRD-in -67.21, -51.18 74.76, -5.57 in-in-in SNCiii in-in ActLoopNT-in 2.7611 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.27, 154.57 APE9-dihe-na 136.39, -174.77 APE8-dihe-in -105.71, 113.39 APE8-rot-in 307.95 APE67-dihe-in -62.18, -16.27 -43.76, -50.15 APE12-dist-in 9.8803 APE11-dist-in 12.0547 APE10-dist-in 6.6597 APE9-dist-in 4.1698 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.74 0.182 0.207 C 320.0 278.0 19 30 24 6 [[183, 456]] 1.0 6uya TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8W3WA Q9NWZ3 162 460 460.0 A1AFO:501 Type1 Active DFGin 6.8581 14.0412 BLAminus -128.73, 174.74 62.23, 85.48 -101.5, 16.16 305.37, 100.31 -63.72, -27.31 in-in in 8.9043 Saltbr-in 3.2317 HRD-in -68.06, -48.89 74.72, -0.26 in-in-in SNCiii in-in ActLoopNT-in 2.8542 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.76, 159.98 APE9-dihe-na 131.71, -173.57 APE8-dihe-in -107.82, 112.48 APE8-rot-in 308.89 APE67-dihe-in -63.58, -17.69 -42.9, -48.96 APE12-dist-in 10.1032 APE11-dist-in 11.7358 APE10-dist-in 6.3675 APE9-dist-in 3.8724 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.976 0.193 0.213 A 323.0 299.0 0 30 30 0 [[183, 456]] 1.0 8w3w TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8W3WB Q9NWZ3 162 459 460.0 A1AFO:501 Type1 Active DFGin 6.7872 14.0994 BLAminus -127.88, 176.03 61.89, 85.58 -101.74, 15.62 305.04, 100.67 -63.48, -27.05 in-in in 8.8783 Saltbr-in 3.3871 HRD-in -68.38, -48.99 75.54, -0.65 in-in-in SNCiii in-in ActLoopNT-in 2.8671 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.98, 161.44 APE9-dihe-na 131.52, -174.84 APE8-dihe-in -106.58, 111.93 APE8-rot-in 306.6 APE67-dihe-in -64.29, -18.3 -40.73, -48.94 APE12-dist-in 10.0498 APE11-dist-in 11.763 APE10-dist-in 6.369 APE9-dist-in 3.796 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.976 0.193 0.213 B 323.0 289.0 9 30 25 5 [[183, 456]] 1.0 8w3w TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8W3WC Q9NWZ3 164 459 460.0 A1AFO:501 Type1 Active DFGin 6.9447 14.0277 BLAminus -131.5, 174.28 63.48, 84.98 -101.2, 15.78 305.71, 101.49 -64.51, -27.86 in-in in 9.1267 Saltbr-in 3.4906 HRD-in -68.01, -49.84 76.05, -0.43 in-in-in SNCiii in-in ActLoopNT-in 2.8494 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.49, 159.76 APE9-dihe-na 131.52, -174.5 APE8-dihe-in -107.14, 112.54 APE8-rot-in 309.3 APE67-dihe-in -64.01, -18.26 -41.84, -47.74 APE12-dist-in 10.0809 APE11-dist-in 11.8818 APE10-dist-in 6.4663 APE9-dist-in 3.8706 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.976 0.193 0.213 C 323.0 288.0 8 30 26 4 [[183, 456]] 1.0 8w3w TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8W3WD Q9NWZ3 164 459 460.0 A1AFO:501 Type1 Active DFGin 6.892 13.9874 BLAminus -130.3, 174.83 63.6, 85.05 -101.8, 16.17 305.68, 100.86 -64.29, -27.61 in-in in 8.9427 Saltbr-in 3.3493 HRD-in -68.44, -48.97 76.22, -0.96 in-in-in SNCiii in-in ActLoopNT-in 2.8502 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.54, 160.0 APE9-dihe-na 132.11, -172.93 APE8-dihe-in -108.54, 112.3 APE8-rot-in 308.85 APE67-dihe-in -64.64, -17.79 -42.26, -47.29 APE12-dist-in 9.9975 APE11-dist-in 11.755 APE10-dist-in 6.4015 APE9-dist-in 3.9192 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.976 0.193 0.213 D 323.0 287.0 9 30 26 4 [[183, 456]] 1.0 8w3w TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8ATLAAA Q9NWZ3 165 459 460.0 O6X:1001 Type1 Active DFGin 6.8629 14.0415 BLAminus -137.77, 171.28 65.58, 85.32 -106.59, 14.48 304.55, 90.88 -55.82, -34.42 in-in in 9.1164 Saltbr-in 3.5432 HRD-in -70.47, -58.64 81.65, 11.33 in-in-in SNCiii in-in ActLoopNT-in 2.8678 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.86, 150.6 APE9-dihe-na 144.35, -175.33 APE8-dihe-in -104.94, 114.45 APE8-rot-in 316.2 APE67-dihe-in -61.27, -24.68 -62.06, -32.75 APE12-dist-in 10.2616 APE11-dist-in 11.7876 APE10-dist-in 6.8529 APE9-dist-in 4.0524 K400A,E401A,E402A TPO345,SEP346 CSO240,TPO345,SEP346 XRAY 2.464 0.201 0.243 AAA 298.0 282.0 13 30 23 7 [[183, 456]] 1.0 8atl TKL_IRAK4_HUMAN TKL 1.3e-83 286.6 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8ATLBBB Q9NWZ3 165 459 460.0 O6X:1001 Type1 Active DFGin 7.0962 13.9429 BLAminus -128.06, 169.98 67.88, 82.87 -108.63, 28.43 316.44, 98.21 -70.71, -32.03 in-in in 8.9827 Saltbr-in 2.8484 HRD-in -68.78, -54.88 81.51, -3.35 in-in-in SNCiii in-in ActLoopNT-in 3.0516 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.25, 137.09 APE9-dihe-na 154.06, -169.33 APE8-dihe-in -119.2, 107.5 APE8-rot-in 319.15 APE67-dihe-in -65.1, -18.02 -48.25, -46.08 APE12-dist-in 10.238 APE11-dist-in 11.6885 APE10-dist-in 6.5229 APE9-dist-in 4.3488 K400A,E401A,E402A TPO345,SEP346 TPO345,SEP346 XRAY 2.464 0.201 0.243 BBB 298.0 271.0 24 30 23 7 [[183, 456]] 1.0 8atl TKL_IRAK4_HUMAN TKL 1.3e-83 286.6 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6EGEA Q9NWZ3 165 459 460.0 DL1:60501 Type1 Active DFGin 6.9399 14.5554 BLAminus -135.12, -165.28 63.61, 72.4 -102.34, 15.54 280.06, 84.72 -58.95, -24.98 in-in in 8.8526 Saltbr-in 2.8056 HRD-in -77.76, -48.68 75.86, 2.37 in-in-in SNCiii in-in ActLoopNT-in 2.7403 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.44, 145.15 APE9-dihe-na 161.1, -176.09 APE8-dihe-in -100.19, 114.19 APE8-rot-in 298.83 APE67-dihe-in -69.58, -10.0 -51.22, -43.25 APE12-dist-in 10.1892 APE11-dist-in 11.5967 APE10-dist-in 6.6726 APE9-dist-in 4.0972 None None None XRAY 1.401 0.179 0.201 A 302.0 270.0 25 30 19 11 [[183, 456]] 1.0 6ege TKL_IRAK4_HUMAN TKL 2.6e-83 285.5 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5T1SB Q9NWZ3 161 459 460.0 76Q:9901 Type1.5_Back Active DFGin 6.8475 14.1018 BLAminus -131.29, 172.67 63.73, 85.01 -103.62, 20.27 304.8, 98.39 -63.0, -38.49 in-in in 8.7432 Saltbr-in 2.8534 HRD-in -68.0, -50.7 78.25, -4.83 in-in-in SNCiii in-in ActLoopNT-in 2.7693 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.12, 154.96 APE9-dihe-na 137.49, -168.77 APE8-dihe-in -112.44, 114.13 APE8-rot-in 311.51 APE67-dihe-in -62.57, -16.72 -41.02, -52.25 APE12-dist-in 9.8992 APE11-dist-in 11.6424 APE10-dist-in 6.2292 APE9-dist-in 3.7675 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.207 0.223 B 301.0 285.0 14 30 25 5 [[183, 456]] 1.0 5t1s TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 2OIDA Q9NWZ3 164 458 460.0 ANP:1 ATPlike Inactive DFGin 6.9661 14.6844 BLAminus -127.55, 175.38 65.24, 82.27 -102.22, 23.11 306.08, 83.19 -64.75, -29.47 out-out out 11.8323 Saltbr-out 5.6903 HRD-in -73.12, -50.9 80.09, -6.55 out-in-in SNCoii in-in ActLoopNT-in 2.8231 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.88, 151.66 APE9-dihe-na 147.16, -164.5 APE8-dihe-in -113.74, 115.19 APE8-rot-in 308.34 APE67-dihe-in -64.44, -17.27 -37.39, -54.71 APE12-dist-in 9.8258 APE11-dist-in 11.5381 APE10-dist-in 6.0721 APE9-dist-in 3.8073 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.244 0.295 A 301.0 266.0 29 30 26 4 [[183, 456]] 1.0 2oid TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 2OIDB Q9NWZ3 164 459 460.0 ANP:2 ATPlike Inactive DFGin 6.94 14.7103 BLAminus -122.34, 171.98 72.6, 82.12 -104.43, 15.54 299.16, 90.11 -59.64, -29.05 in-out in 8.9076 Saltbr-out 3.9298 HRD-in -75.58, -47.6 78.52, -5.87 out-in-in SNCoii in-in ActLoopNT-in 2.7304 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.71, 158.05 APE9-dihe-na 142.8, -157.21 APE8-dihe-in -121.23, 117.8 APE8-rot-in 309.19 APE67-dihe-in -67.67, -11.87 -44.28, -49.35 APE12-dist-in 10.1904 APE11-dist-in 11.7427 APE10-dist-in 6.5221 APE9-dist-in 3.7233 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.244 0.295 B 301.0 274.0 22 30 24 6 [[183, 456]] 1.0 2oid TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 2OIDC Q9NWZ3 166 458 460.0 ANP:3 ATPlike Inactive DFGin 6.806 13.9727 BLAminus -130.4, 175.52 61.07, 75.53 -96.05, 32.37 309.84, 82.72 -74.67, -28.22 in-out in 8.9014 Saltbr-out 4.0238 HRD-in -62.6, -55.98 80.8, 1.53 out-in-in SNCoii in-in ActLoopNT-in 3.032 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.92, 158.28 APE9-dihe-na 138.01, -176.06 APE8-dihe-in -106.21, 116.22 APE8-rot-in 304.08 APE67-dihe-in -63.21, -15.57 -55.27, -41.4 APE12-dist-in 9.6871 APE11-dist-in 11.4204 APE10-dist-in 6.3612 APE9-dist-in 3.8779 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.244 0.295 C 301.0 259.0 34 30 24 6 [[183, 456]] 1.0 2oid TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 7C2WA Q9NWZ3 164 458 460.0 YTH:345,FJ9:501 Allosteric,Type1 Inactive DFGin 7.0081 14.1007 BLAminus -138.82, 174.74 56.43, 93.02 -113.13, 26.12 310.56, 79.64 -63.58, -29.99 in-out in 8.5567 Saltbr-out 5.7898 HRD-in -76.31, -45.04 70.93, 17.16 out-in-in SNCoii in-in ActLoopNT-in 2.9224 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -98.24, 170.16 APE9-dihe-na 117.69, -175.19 APE8-dihe-in -120.66, 113.54 APE8-rot-in 311.23 APE67-dihe-in -56.83, -22.49 -39.44, -59.61 APE12-dist-in 9.3821 APE11-dist-in 11.4744 APE10-dist-in 6.0252 APE9-dist-in 3.9123 None SEP346 YTH345,SEP346 XRAY 3.2 0.266 0.355 A 296.0 295.0 0 30 30 0 [[183, 456]] 1.0 7c2w TKL_IRAK4_HUMAN TKL 3.8e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 7C2WB Q9NWZ3 163 458 460.0 YTH:345,FJ9:501 Allosteric,Type1 Inactive DFGin 6.9785 14.6116 BLAminus -136.45, 162.53 68.37, 80.41 -104.06, 37.12 313.57, 98.38 -78.22, -38.45 in-out in 9.1185 Saltbr-out 6.5735 HRD-in -83.19, -43.83 70.57, 2.83 out-in-in SNCoii in-in ActLoopNT-in 2.6388 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.34, 141.77 APE9-dihe-na 153.89, -173.46 APE8-dihe-in -107.61, 111.76 APE8-rot-in 314.98 APE67-dihe-in -66.34, -21.87 -50.88, -45.35 APE12-dist-in 10.6643 APE11-dist-in 11.5527 APE10-dist-in 6.5733 APE9-dist-in 3.7907 None SEP346 YTH345,SEP346 XRAY 3.2 0.266 0.355 B 296.0 296.0 0 30 30 0 [[183, 456]] 1.0 7c2w TKL_IRAK4_HUMAN TKL 3.8e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 7C2WC Q9NWZ3 164 458 460.0 YTH:345,FJ9:501 Allosteric,Type1 Inactive DFGin 6.572 14.2817 BLAminus -111.0, 169.93 74.2, 68.59 -90.48, 38.19 306.97, 110.28 -72.84, -29.79 in-out in 8.7988 Saltbr-out 5.1436 HRD-in -81.6, -51.31 75.53, 23.82 out-in-in SNCoii in-in ActLoopNT-in 3.0948 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.53, 139.11 APE9-dihe-na 144.09, -177.78 APE8-dihe-in -103.04, 109.59 APE8-rot-in 305.86 APE67-dihe-in -65.96, -16.53 -57.46, -35.15 APE12-dist-in 10.9103 APE11-dist-in 11.7507 APE10-dist-in 6.7479 APE9-dist-in 4.2238 None SEP346 YTH345,SEP346 XRAY 3.2 0.266 0.355 C 296.0 295.0 0 30 30 0 [[183, 456]] 1.0 7c2w TKL_IRAK4_HUMAN TKL 3.8e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 7C2WD Q9NWZ3 164 458 460.0 YTH:345,FJ9:501 Allosteric,Type1 Inactive DFGin 7.1196 14.474 BLAminus -122.46, 161.89 73.23, 111.34 -132.13, 33.23 304.46, 95.4 -62.48, -38.96 in-out in 8.8964 Saltbr-out 3.7048 HRD-in -82.62, -42.53 65.68, 19.17 out-in-in SNCoii in-in ActLoopNT-in 2.4233 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.21, 150.63 APE9-dihe-na 117.03, -166.09 APE8-dihe-in -99.2, 111.11 APE8-rot-in 306.68 APE67-dihe-in -65.8, -26.71 -55.01, -29.38 APE12-dist-in 10.7708 APE11-dist-in 11.4005 APE10-dist-in 6.0408 APE9-dist-in 4.3734 None SEP346 YTH345,SEP346 XRAY 3.2 0.266 0.355 D 296.0 295.0 0 30 30 0 [[183, 456]] 1.0 7c2w TKL_IRAK4_HUMAN TKL 3.8e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 2O8YA Q9NWZ3 165 459 460.0 No_ligand No_ligand Inactive DFGin 6.8416 14.5911 BLAminus -132.39, 177.22 66.07, 84.3 -105.54, 20.57 305.43, 80.78 -65.44, -21.01 in-out in 9.2203 Saltbr-out 5.2604 HRD-in -67.22, -51.44 76.47, -5.87 out-in-in SNCoii in-in ActLoopNT-in 2.6453 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.99, 161.49 APE9-dihe-na 137.04, -166.6 APE8-dihe-in -112.18, 123.59 APE8-rot-in 299.28 APE67-dihe-in -59.66, -14.58 -45.01, -56.42 APE12-dist-in 10.1061 APE11-dist-in 11.7981 APE10-dist-in 6.4734 APE9-dist-in 3.6984 None TPO342,TPO345 MSE192,MSE237,MSE265,MSE287,TPO342,MSE344,TPO345,MSE355,MSE418,MSE429,MSE457 XRAY 2.4 0.246 0.289 A 298.0 280.0 15 30 25 5 [[183, 456]] 1.0 2o8y TKL_IRAK4_HUMAN TKL 3.9e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 2O8YB Q9NWZ3 165 459 460.0 No_ligand No_ligand Inactive DFGin 6.9821 14.8022 BLAminus -133.86, -178.63 62.43, 89.29 -111.36, 23.7 306.19, 76.11 -69.27, -12.74 in-out in 8.717 Saltbr-out 4.0968 HRD-in -66.08, -48.44 73.53, 0.66 out-in-in SNCoii in-in ActLoopNT-in 2.8454 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.84, 167.68 APE9-dihe-na 128.52, -172.33 APE8-dihe-in -109.54, 116.11 APE8-rot-in 303.67 APE67-dihe-in -57.63, -18.12 -43.35, -51.59 APE12-dist-in 10.3467 APE11-dist-in 11.6456 APE10-dist-in 6.2992 APE9-dist-in 3.8249 None TPO342,TPO345 MSE192,MSE237,MSE265,MSE287,TPO342,MSE344,TPO345,MSE355,MSE418,MSE429,MSE457 XRAY 2.4 0.246 0.289 B 298.0 277.0 18 30 26 4 [[183, 456]] 1.0 2o8y TKL_IRAK4_HUMAN TKL 3.9e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 2OIBB Q9NWZ3 164 459 460.0 No_ligand No_ligand Inactive DFGin 6.9115 14.3665 BLAminus -130.73, 177.63 60.98, 89.06 -107.76, 18.75 304.42, 96.69 -61.49, -32.17 in-out in 8.7105 Saltbr-out 4.9735 HRD-in -73.5, -47.34 78.41, -6.88 out-in-in SNCoii in-in ActLoopNT-in 2.603 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.65, 163.49 APE9-dihe-na 129.0, -175.48 APE8-dihe-in -112.62, 115.8 APE8-rot-in 312.17 APE67-dihe-in -59.96, -17.14 -45.91, -50.69 APE12-dist-in 10.1468 APE11-dist-in 11.7665 APE10-dist-in 6.2429 APE9-dist-in 3.6764 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.0 0.224 0.27 B 301.0 280.0 16 30 25 5 [[183, 456]] 1.0 2oib TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 2OIBD Q9NWZ3 162 459 460.0 No_ligand No_ligand Inactive DFGin 6.869 14.1067 BLAminus -132.48, 179.0 58.57, 90.78 -108.79, 13.93 305.25, 93.63 -59.23, -27.46 in-out in 8.5749 Saltbr-out 3.9104 HRD-in -70.94, -53.7 84.55, -7.25 out-in-in SNCoii in-in ActLoopNT-in 2.7686 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.13, 162.11 APE9-dihe-na 127.99, -173.2 APE8-dihe-in -112.52, 109.59 APE8-rot-in 304.94 APE67-dihe-in -66.63, -13.02 -35.96, -52.59 APE12-dist-in 10.1459 APE11-dist-in 11.7056 APE10-dist-in 6.2291 APE9-dist-in 3.8573 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.0 0.224 0.27 D 301.0 291.0 7 30 30 0 [[183, 456]] 1.0 2oib TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6F3DA Q9NWZ3 164 458 460.0 CJT:502 Type1 Inactive DFGin 6.8568 14.9701 BLAminus -126.43, 173.85 60.13, 90.52 -108.92, 21.74 303.63, 100.05 -64.69, -33.45 in-out in 8.7483 Saltbr-out 7.0584 HRD-in -69.56, -52.85 80.84, -6.56 out-in-in SNCoii in-in ActLoopNT-in 2.7424 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.18, 157.03 APE9-dihe-na 132.14, -169.02 APE8-dihe-in -110.38, 114.0 APE8-rot-in 313.11 APE67-dihe-in -62.64, -17.73 -54.17, -36.33 APE12-dist-in 9.7838 APE11-dist-in 11.7103 APE10-dist-in 6.2087 APE9-dist-in 3.7231 None TPO345,SEP346 TPO345,SEP346 XRAY 2.38 0.199 0.227 A 295.0 279.0 16 30 23 7 [[183, 456]] 1.0 6f3d TKL_IRAK4_HUMAN TKL 3.8e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6F3DB Q9NWZ3 164 458 460.0 CJT:502 Type1 Inactive DFGin 6.9062 14.8413 BLAminus -125.62, 174.19 59.72, 91.48 -109.06, 21.2 303.98, 99.18 -64.05, -33.92 in-out in 8.7272 Saltbr-out 6.88 HRD-in -68.72, -52.8 80.28, -5.29 out-in-in SNCoii in-in ActLoopNT-in 2.7186 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.53, 156.8 APE9-dihe-na 131.54, -170.51 APE8-dihe-in -110.25, 113.69 APE8-rot-in 313.84 APE67-dihe-in -63.36, -18.29 -54.74, -34.7 APE12-dist-in 9.7719 APE11-dist-in 11.4492 APE10-dist-in 5.984 APE9-dist-in 3.7841 None TPO345,SEP346 TPO345,SEP346 XRAY 2.38 0.199 0.227 B 295.0 285.0 10 30 23 7 [[183, 456]] 1.0 6f3d TKL_IRAK4_HUMAN TKL 3.8e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6F3EA Q9NWZ3 164 458 460.0 CJQ:502 Type1 Inactive DFGin 6.9195 14.2196 BLAminus -136.23, 176.33 63.94, 83.09 -106.72, 21.4 311.25, 94.04 -69.13, -19.86 in-out in 8.6751 Saltbr-out 6.7089 HRD-in -63.75, -48.88 78.04, -8.73 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.08, 140.42 APE9-dihe-na 140.98, -176.61 APE8-dihe-in -92.66, 119.69 APE8-rot-in 314.49 APE67-dihe-in -63.0, -18.03 -56.97, -37.35 APE12-dist-in 10.5652 APE11-dist-in 11.8395 APE10-dist-in 6.6189 APE9-dist-in 4.1748 None TPO342,TPO345 TPO342,TPO345 XRAY 2.67 0.201 0.254 A 295.0 272.0 23 30 22 8 [[183, 456]] 1.0 6f3e TKL_IRAK4_HUMAN TKL 3.8e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6F3EB Q9NWZ3 164 458 460.0 CJQ:501 Type1 Inactive DFGin 6.9236 14.146 BLAminus -136.52, 172.28 70.33, 84.0 -110.15, 21.49 311.14, 94.15 -69.02, -20.02 in-out in 8.6523 Saltbr-out 5.4897 HRD-in -63.87, -48.98 77.6, -8.2 out-in-in SNCoii in-in ActLoopNT-in 2.7351 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.45, 141.04 APE9-dihe-na 142.02, -175.79 APE8-dihe-in -93.38, 119.46 APE8-rot-in 315.35 APE67-dihe-in -63.37, -18.21 -57.51, -36.62 APE12-dist-in 10.4116 APE11-dist-in 11.628 APE10-dist-in 6.5015 APE9-dist-in 4.2208 None TPO342,TPO345 TPO342,TPO345 XRAY 2.67 0.201 0.254 B 295.0 284.0 11 30 25 5 [[183, 456]] 1.0 6f3e TKL_IRAK4_HUMAN TKL 3.8e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6N8GB Q9NWZ3 164 459 460.0 KFD:501 Type1 Inactive DFGin 6.6281 14.1098 BLAminus -131.69, 166.82 75.96, 91.11 -108.83, 12.45 307.58, 107.24 -56.0, -36.28 in-out in 8.7951 Saltbr-out 3.6551 HRD-in -73.96, -48.59 79.13, -6.97 out-in-in SNCoii in-in ActLoopNT-in 2.8853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.24, 163.81 APE9-dihe-na 129.93, -172.68 APE8-dihe-in -114.06, 121.63 APE8-rot-in 306.03 APE67-dihe-in -58.98, -19.75 -56.52, -43.04 APE12-dist-in 9.8694 APE11-dist-in 12.0081 APE10-dist-in 6.4514 APE9-dist-in 3.6106 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.0 0.177 0.22 B 297.0 286.0 10 30 25 5 [[183, 456]] 1.0 6n8g TKL_IRAK4_HUMAN TKL 3.9e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8BR5AAA Q9NWZ3 163 459 460.0 R73:501 Type1 Inactive DFGin 6.8909 13.5487 BLAminus -135.64, 166.52 72.95, 87.11 -114.61, 20.95 314.97, 96.05 -63.79, -34.13 in-out in 8.5773 Saltbr-out 5.1263 HRD-in -65.01, -58.54 82.12, 4.04 out-in-in SNCoii in-in ActLoopNT-in 2.6426 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.82, 159.99 APE9-dihe-na 128.75, -171.24 APE8-dihe-in -115.19, 111.48 APE8-rot-in 311.1 APE67-dihe-in -62.63, -23.51 -40.08, -50.26 APE12-dist-in 9.8978 APE11-dist-in 11.8187 APE10-dist-in 6.2927 APE9-dist-in 3.5113 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.7 0.215 0.254 AAA 299.0 285.0 12 30 26 4 [[183, 456]] 1.0 8br5 TKL_IRAK4_HUMAN TKL 4e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8BR5BBB Q9NWZ3 162 459 460.0 R73:501 Type1 Inactive DFGin 6.8575 13.7617 BLAminus -136.08, 166.61 73.3, 87.27 -114.6, 19.85 314.86, 95.64 -65.31, -30.39 in-out in 8.5226 Saltbr-out 3.7294 HRD-in -65.19, -58.29 82.32, 3.9 out-in-in SNCoii in-in ActLoopNT-in 3.1133 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.6, 159.09 APE9-dihe-na 128.61, -173.24 APE8-dihe-in -115.27, 111.19 APE8-rot-in 312.87 APE67-dihe-in -62.24, -23.3 -41.16, -49.65 APE12-dist-in 10.2149 APE11-dist-in 11.8096 APE10-dist-in 6.2677 APE9-dist-in 3.5494 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.7 0.215 0.254 BBB 299.0 286.0 12 30 25 5 [[183, 456]] 1.0 8br5 TKL_IRAK4_HUMAN TKL 4e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8BR5CCC Q9NWZ3 163 459 460.0 R73:501 Type1 Inactive DFGin 6.708 13.7926 BLAminus -136.19, 166.86 72.98, 86.7 -114.08, 20.57 315.82, 89.7 -62.71, -31.97 in-out in 8.6814 Saltbr-out 3.7563 HRD-in -65.25, -58.07 82.96, 3.39 out-in-in SNCoii in-in ActLoopNT-in 2.958 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.36, 158.08 APE9-dihe-na 127.09, -172.58 APE8-dihe-in -114.98, 111.31 APE8-rot-in 311.74 APE67-dihe-in -61.49, -24.18 -41.35, -49.9 APE12-dist-in 10.074 APE11-dist-in 11.8248 APE10-dist-in 6.1654 APE9-dist-in 3.5104 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.7 0.215 0.254 CCC 299.0 284.0 13 30 24 6 [[183, 456]] 1.0 8br5 TKL_IRAK4_HUMAN TKL 4e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8BR5DDD Q9NWZ3 164 459 460.0 R73:501 Type1 Inactive DFGin 6.9291 13.6331 BLAminus -135.77, 166.02 73.96, 87.25 -114.76, 19.82 314.36, 95.52 -65.27, -32.15 in-out in 8.387 Saltbr-out 3.6821 HRD-in -64.82, -58.41 82.56, 3.65 out-in-in SNCoii in-in ActLoopNT-in 2.6458 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.87, 159.3 APE9-dihe-na 128.38, -172.65 APE8-dihe-in -115.23, 111.34 APE8-rot-in 311.38 APE67-dihe-in -63.77, -22.78 -39.6, -50.55 APE12-dist-in 9.8784 APE11-dist-in 11.8965 APE10-dist-in 6.3607 APE9-dist-in 3.5306 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.7 0.215 0.254 DDD 299.0 285.0 11 30 26 4 [[183, 456]] 1.0 8br5 TKL_IRAK4_HUMAN TKL 4e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4XS2A Q9NWZ3 163 459 460.0 42P:501 Type1 Inactive DFGin 6.9606 13.8175 BLAminus -139.83, 178.59 62.42, 89.38 -110.92, 32.37 305.3, 93.64 -72.26, -32.74 in-out in 8.1825 Saltbr-out 3.8869 HRD-in -66.15, -47.6 71.03, 8.51 out-in-in SNCoii in-in ActLoopNT-in 2.7232 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.97, 150.86 APE9-dihe-na 147.38, -162.61 APE8-dihe-in -121.73, 101.64 APE8-rot-in 312.4 APE67-dihe-in -60.48, -25.99 -31.6, -51.75 APE12-dist-in 10.2037 APE11-dist-in 11.5946 APE10-dist-in 6.3636 APE9-dist-in 3.8944 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.73 0.265 0.285 A 301.0 286.0 11 30 26 4 [[183, 456]] 1.0 4xs2 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4XS2C Q9NWZ3 164 460 460.0 42P:501 Type1 Inactive DFGin 7.0029 14.1829 BLAminus -139.75, 179.01 62.21, 89.32 -110.78, 33.07 304.95, 93.8 -72.17, -33.09 in-out in 8.9033 Saltbr-out 4.9313 HRD-in -66.02, -47.7 71.09, 8.03 out-in-in SNCoii in-in ActLoopNT-in 2.7233 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.28, 151.46 APE9-dihe-na 147.22, -162.81 APE8-dihe-in -121.29, 101.83 APE8-rot-in 312.18 APE67-dihe-in -59.63, -26.92 -31.63, -51.62 APE12-dist-in 10.0762 APE11-dist-in 11.6006 APE10-dist-in 6.3679 APE9-dist-in 3.8956 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.73 0.265 0.285 C 301.0 284.0 13 30 26 4 [[183, 456]] 1.0 4xs2 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4XS2D Q9NWZ3 164 459 460.0 42P:501 Type1 Inactive DFGin 7.0245 14.0469 BLAminus -139.44, 179.02 62.41, 89.35 -110.92, 32.6 305.38, 93.57 -72.63, -32.43 in-out in 8.8747 Saltbr-out 3.8974 HRD-in -65.82, -48.05 71.33, 8.53 out-in-in SNCoii in-in ActLoopNT-in 2.7249 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.39, 151.35 APE9-dihe-na 147.15, -162.94 APE8-dihe-in -121.47, 101.64 APE8-rot-in 312.23 APE67-dihe-in -59.77, -26.66 -31.67, -51.78 APE12-dist-in 10.2268 APE11-dist-in 11.5759 APE10-dist-in 6.3602 APE9-dist-in 3.9119 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.73 0.265 0.285 D 301.0 280.0 16 30 25 5 [[183, 456]] 1.0 4xs2 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4YO6A Q9NWZ3 163 459 460.0 4GD:501 Type1 Inactive DFGin 6.8617 13.9601 BLAminus -129.91, 177.67 60.76, 83.02 -105.78, 15.82 308.47, 100.26 -61.62, -37.54 in-out in 8.6354 Saltbr-out 3.7566 HRD-in -64.27, -52.67 78.0, -3.84 out-in-in SNCoii in-in ActLoopNT-in 2.6627 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.75, 154.49 APE9-dihe-na 134.67, -169.9 APE8-dihe-in -113.48, 114.93 APE8-rot-in 316.38 APE67-dihe-in -59.93, -21.93 -40.75, -53.54 APE12-dist-in 9.8108 APE11-dist-in 11.7169 APE10-dist-in 6.295 APE9-dist-in 3.7922 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.32 0.199 0.225 A 301.0 289.0 8 30 27 3 [[183, 456]] 1.0 4yo6 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4YO6C Q9NWZ3 164 460 460.0 4GD:501 Type1 Inactive DFGin 6.9084 14.067 BLAminus -128.29, 178.22 59.78, 82.76 -103.95, 17.07 307.43, 101.27 -61.63, -37.69 in-out in 8.812 Saltbr-out 4.7022 HRD-in -64.18, -52.59 77.65, -3.55 out-in-in SNCoii in-in ActLoopNT-in 2.6722 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.3, 157.9 APE9-dihe-na 134.38, -169.38 APE8-dihe-in -113.09, 114.58 APE8-rot-in 315.5 APE67-dihe-in -61.27, -21.5 -39.75, -52.67 APE12-dist-in 9.9432 APE11-dist-in 11.7304 APE10-dist-in 6.2981 APE9-dist-in 3.7593 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.32 0.199 0.225 C 301.0 289.0 8 30 25 5 [[183, 456]] 1.0 4yo6 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4YP8B Q9NWZ3 161 459 460.0 4GF:501 Type1 Inactive DFGin 6.9172 14.4445 BLAminus -129.86, 179.56 60.17, 77.95 -104.22, 26.32 310.53, 95.0 -66.78, -33.18 in-out in 8.6851 Saltbr-out 3.9622 HRD-in -57.85, -50.75 76.66, -4.15 out-in-in SNCoii in-in ActLoopNT-in 2.8535 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.74, 150.82 APE9-dihe-na 140.12, -173.75 APE8-dihe-in -103.4, 115.49 APE8-rot-in 310.63 APE67-dihe-in -65.34, -17.03 -41.64, -51.23 APE12-dist-in 10.0453 APE11-dist-in 11.5809 APE10-dist-in 6.3191 APE9-dist-in 3.9048 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 B 301.0 281.0 18 30 24 6 [[183, 456]] 1.0 4yp8 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4YP8C Q9NWZ3 164 460 460.0 4GF:501 Type1 Inactive DFGin 6.8212 14.4085 BLAminus -129.81, 179.51 59.35, 79.05 -103.24, 26.6 309.61, 96.69 -66.38, -34.02 in-out in 8.8507 Saltbr-out 4.6837 HRD-in -59.31, -50.52 77.45, -5.42 out-in-in SNCoii in-in ActLoopNT-in 2.7895 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.88, 150.51 APE9-dihe-na 141.79, -174.18 APE8-dihe-in -103.25, 114.63 APE8-rot-in 311.45 APE67-dihe-in -64.61, -17.76 -41.38, -51.75 APE12-dist-in 10.1488 APE11-dist-in 11.6263 APE10-dist-in 6.34 APE9-dist-in 3.9449 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 C 301.0 290.0 7 30 26 4 [[183, 456]] 1.0 4yp8 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4YP8D Q9NWZ3 164 459 460.0 4GF:501 Type1 Inactive DFGin 6.8543 14.3193 BLAminus -129.62, 178.91 61.84, 77.53 -103.67, 26.43 310.15, 95.74 -66.28, -34.21 in-out in 8.9151 Saltbr-out 3.8024 HRD-in -59.75, -49.91 75.93, -3.95 out-in-in SNCoii in-in ActLoopNT-in 2.7897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.59, 153.02 APE9-dihe-na 138.42, -174.86 APE8-dihe-in -103.4, 114.55 APE8-rot-in 310.75 APE67-dihe-in -64.11, -17.03 -41.21, -51.68 APE12-dist-in 10.0152 APE11-dist-in 11.5854 APE10-dist-in 6.3272 APE9-dist-in 3.9224 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 D 301.0 288.0 8 30 26 4 [[183, 456]] 1.0 4yp8 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4ZTLD Q9NWZ3 164 460 460.0 4S1:501 Type1 Inactive DFGin 7.408 13.8584 BLAminus -116.1, 179.03 57.27, 97.63 -119.15, 26.56 307.31, 90.9 -69.0, -33.74 in-out in 8.834 Saltbr-out 4.0326 HRD-in -66.21, -53.23 78.61, -4.19 out-in-in SNCoii in-in ActLoopNT-in 2.759 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.29, 153.79 APE9-dihe-na 136.38, -168.38 APE8-dihe-in -115.43, 114.11 APE8-rot-in 309.49 APE67-dihe-in -62.14, -19.04 -39.35, -53.51 APE12-dist-in 9.8775 APE11-dist-in 11.6541 APE10-dist-in 6.2719 APE9-dist-in 3.739 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.39 0.226 0.251 D 301.0 288.0 9 30 26 4 [[183, 456]] 1.0 4ztl TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4ZTMC Q9NWZ3 164 460 460.0 4S2:501 Type1 Inactive DFGin 7.0479 13.9738 BLAminus -126.04, 176.22 63.0, 87.68 -110.92, 16.43 306.51, 93.12 -61.69, -39.3 in-out in 8.6617 Saltbr-out 3.7253 HRD-in -70.81, -43.23 73.84, -1.89 out-in-in SNCoii in-in ActLoopNT-in 2.6646 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.63, 152.69 APE9-dihe-na 136.92, -172.96 APE8-dihe-in -111.3, 109.86 APE8-rot-in 307.24 APE67-dihe-in -64.59, -17.33 -36.72, -48.95 APE12-dist-in 9.9325 APE11-dist-in 11.7469 APE10-dist-in 6.2763 APE9-dist-in 3.8108 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.66 0.195 0.226 C 301.0 285.0 12 30 26 4 [[183, 456]] 1.0 4ztm TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4ZTNA Q9NWZ3 163 459 460.0 4S3:501 Type1 Inactive DFGin 6.9122 13.7481 BLAminus -132.76, 175.45 64.22, 82.16 -105.35, 20.86 308.35, 101.07 -66.05, -41.88 in-out in 8.6944 Saltbr-out 3.9124 HRD-in -63.92, -51.66 76.82, -0.35 out-in-in SNCoii in-in ActLoopNT-in 2.7616 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.06, 158.04 APE9-dihe-na 129.58, -170.0 APE8-dihe-in -113.45, 112.1 APE8-rot-in 310.07 APE67-dihe-in -62.7, -20.05 -38.09, -52.45 APE12-dist-in 9.814 APE11-dist-in 11.7179 APE10-dist-in 6.2346 APE9-dist-in 3.8197 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.23 0.21 0.224 A 301.0 289.0 8 30 26 4 [[183, 456]] 1.0 4ztn TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4ZTNC Q9NWZ3 164 460 460.0 4S3:501 Type1 Inactive DFGin 6.9885 13.9156 BLAminus -131.78, 175.79 64.01, 82.42 -105.46, 21.38 307.95, 100.83 -65.91, -41.86 in-out in 8.7626 Saltbr-out 5.2416 HRD-in -64.24, -51.41 76.71, -0.47 out-in-in SNCoii in-in ActLoopNT-in 2.7669 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.03, 158.37 APE9-dihe-na 130.24, -169.83 APE8-dihe-in -112.97, 111.72 APE8-rot-in 309.39 APE67-dihe-in -62.29, -20.6 -37.85, -52.05 APE12-dist-in 9.8427 APE11-dist-in 11.7416 APE10-dist-in 6.2439 APE9-dist-in 3.8114 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.23 0.21 0.224 C 301.0 287.0 10 30 25 5 [[183, 456]] 1.0 4ztn TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4ZTND Q9NWZ3 164 459 460.0 4S3:501 Type1 Inactive DFGin 6.9666 13.8616 BLAminus -131.47, 175.86 63.89, 82.53 -105.44, 21.0 308.32, 101.14 -65.65, -42.51 in-out in 8.5619 Saltbr-out 4.5879 HRD-in -64.48, -51.67 77.17, -0.49 out-in-in SNCoii in-in ActLoopNT-in 2.7672 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.0, 157.79 APE9-dihe-na 130.37, -169.74 APE8-dihe-in -112.98, 111.75 APE8-rot-in 309.39 APE67-dihe-in -62.26, -20.04 -38.34, -52.0 APE12-dist-in 9.8419 APE11-dist-in 11.7142 APE10-dist-in 6.2313 APE9-dist-in 3.8469 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.23 0.21 0.224 D 301.0 288.0 8 30 26 4 [[183, 456]] 1.0 4ztn TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5K75B Q9NWZ3 163 458 460.0 6QX:504 Type1 Inactive DFGin 6.9421 14.4597 BLAminus -128.01, 170.74 65.21, 84.11 -102.46, 21.31 309.47, 102.25 -65.48, -35.7 in-out in 8.9911 Saltbr-out 4.824 HRD-in -67.05, -49.26 79.32, -10.55 out-in-in SNCoii in-in ActLoopNT-in 2.8439 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.97, 151.22 APE9-dihe-na 136.05, -171.59 APE8-dihe-in -107.24, 112.63 APE8-rot-in 315.34 APE67-dihe-in -64.6, -19.05 -39.76, -49.9 APE12-dist-in 10.3108 APE11-dist-in 11.9727 APE10-dist-in 6.4513 APE9-dist-in 3.9883 None TPO345,SEP346 TPO345,SEP346 XRAY 2.03 0.24 0.253 B 301.0 276.0 20 30 24 6 [[183, 456]] 1.0 5k75 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5K75C Q9NWZ3 164 458 460.0 6QX:503 Type1 Inactive DFGin 6.8715 14.6093 BLAminus -129.83, 165.29 65.74, 85.81 -102.99, 19.43 308.09, 104.56 -63.96, -32.44 in-out in 9.2956 Saltbr-out 5.3423 HRD-in -68.14, -49.27 78.52, -10.11 out-in-in SNCoii in-in ActLoopNT-in 2.8545 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.89, 149.58 APE9-dihe-na 136.24, -173.39 APE8-dihe-in -107.03, 113.02 APE8-rot-in 310.39 APE67-dihe-in -64.46, -18.84 -41.97, -48.83 APE12-dist-in 10.2092 APE11-dist-in 11.9086 APE10-dist-in 6.4163 APE9-dist-in 3.9225 None TPO345,SEP346 TPO345,SEP346 XRAY 2.03 0.24 0.253 C 301.0 284.0 11 30 24 6 [[183, 456]] 1.0 5k75 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5K75D Q9NWZ3 164 458 460.0 6QX:503 Type1 Inactive DFGin 6.8707 14.653 BLAminus -129.48, 170.81 65.18, 85.95 -104.57, 20.05 308.12, 102.19 -64.37, -31.42 in-out in 9.3321 Saltbr-out 6.1167 HRD-in -68.05, -50.39 79.24, -8.5 out-in-in SNCoii in-in ActLoopNT-in 2.8485 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.04, 148.95 APE9-dihe-na 137.45, -171.0 APE8-dihe-in -108.28, 111.67 APE8-rot-in 312.02 APE67-dihe-in -64.11, -18.6 -47.87, -42.01 APE12-dist-in 10.0957 APE11-dist-in 11.8943 APE10-dist-in 6.4432 APE9-dist-in 4.0163 None TPO345,SEP346 TPO345,SEP346 XRAY 2.03 0.24 0.253 D 301.0 282.0 13 30 25 5 [[183, 456]] 1.0 5k75 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5K76A Q9NWZ3 165 458 460.0 6R1:501 Type1 Inactive DFGin 6.8534 14.8634 BLAminus -121.43, -179.95 54.49, 86.78 -104.23, 22.41 304.48, 98.38 -65.05, -34.55 in-out in 8.9195 Saltbr-out 3.6512 HRD-in -65.07, -46.83 74.96, -9.88 out-in-in SNCoii in-in ActLoopNT-in 2.8021 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.56, 155.66 APE9-dihe-na 131.31, -170.57 APE8-dihe-in -106.81, 113.19 APE8-rot-in 313.21 APE67-dihe-in -69.62, -11.45 -41.08, -46.98 APE12-dist-in 10.3096 APE11-dist-in 11.7027 APE10-dist-in 6.1775 APE9-dist-in 3.6795 None TPO345,SEP346 TPO345,SEP346 XRAY 2.74 0.218 0.246 A 301.0 272.0 22 30 24 6 [[183, 456]] 1.0 5k76 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5KX8C Q9NWZ3 164 460 460.0 6YE:501 Type1 Inactive DFGin 6.7104 13.6602 BLAminus -135.77, -177.74 57.62, 85.63 -110.73, 16.78 314.9, 103.1 -62.24, -34.76 in-out in 8.5149 Saltbr-out 5.49 HRD-in -63.77, -49.86 77.11, -1.48 out-in-in SNCoii in-in ActLoopNT-in 2.6554 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.71, 147.84 APE9-dihe-na 142.61, -171.78 APE8-dihe-in -109.37, 108.08 APE8-rot-in 308.72 APE67-dihe-in -61.99, -21.4 -33.87, -50.94 APE12-dist-in 9.982 APE11-dist-in 11.7199 APE10-dist-in 6.4828 APE9-dist-in 3.943 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.671 0.206 0.233 C 301.0 290.0 7 30 26 4 [[183, 456]] 1.0 5kx8 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5T1SA Q9NWZ3 163 459 460.0 76Q:9901 Type1 Inactive DFGin 6.9238 14.2156 BLAminus -131.2, 172.67 63.25, 85.32 -103.49, 19.58 304.94, 98.19 -62.83, -37.96 in-out in 8.3968 Saltbr-out 4.3357 HRD-in -67.98, -50.93 78.51, -4.97 out-in-in SNCoii in-in ActLoopNT-in 2.7268 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.42, 155.39 APE9-dihe-na 136.97, -168.9 APE8-dihe-in -113.04, 114.06 APE8-rot-in 312.08 APE67-dihe-in -62.34, -17.03 -41.2, -52.01 APE12-dist-in 10.2827 APE11-dist-in 11.6358 APE10-dist-in 6.2313 APE9-dist-in 3.7723 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.207 0.223 A 301.0 283.0 14 30 27 3 [[183, 456]] 1.0 5t1s TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5T1SC Q9NWZ3 164 460 460.0 76Q:9901 Type1 Inactive DFGin 6.925 14.585 BLAminus -131.08, 172.79 63.77, 84.62 -102.6, 19.98 305.07, 98.68 -62.65, -38.92 in-out in 9.0801 Saltbr-out 5.1382 HRD-in -67.96, -50.84 78.65, -4.29 out-in-in SNCoii in-in ActLoopNT-in 2.7708 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.17, 155.14 APE9-dihe-na 137.47, -168.59 APE8-dihe-in -112.75, 113.96 APE8-rot-in 311.75 APE67-dihe-in -62.32, -17.93 -40.65, -52.04 APE12-dist-in 9.7709 APE11-dist-in 11.6606 APE10-dist-in 6.2474 APE9-dist-in 3.771 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.207 0.223 C 301.0 287.0 10 30 25 5 [[183, 456]] 1.0 5t1s TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5T1TA Q9NWZ3 163 459 460.0 76P:9901 Type1 Inactive DFGin 6.887 13.9561 BLAminus -133.7, 176.64 67.32, 81.1 -107.48, 15.55 308.96, 93.07 -63.8, -32.84 in-out in 8.8561 Saltbr-out 4.6921 HRD-in -67.26, -50.15 75.88, -1.73 out-in-in SNCoii in-in ActLoopNT-in 2.7428 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.24, 158.51 APE9-dihe-na 129.02, -169.71 APE8-dihe-in -114.13, 114.14 APE8-rot-in 310.96 APE67-dihe-in -64.47, -17.8 -40.74, -50.47 APE12-dist-in 9.8476 APE11-dist-in 11.7553 APE10-dist-in 6.3662 APE9-dist-in 3.8797 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.34 0.207 0.228 A 301.0 286.0 11 30 24 6 [[183, 456]] 1.0 5t1t TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5T1TB Q9NWZ3 161 459 460.0 76P:9901 Type1 Inactive DFGin 6.9393 13.9935 BLAminus -132.8, 176.38 67.63, 80.73 -108.02, 15.73 309.33, 93.37 -64.25, -32.84 in-out in 8.925 Saltbr-out 4.0346 HRD-in -67.17, -50.18 76.11, -2.27 out-in-in SNCoii in-in ActLoopNT-in 2.7407 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.26, 158.14 APE9-dihe-na 129.32, -169.9 APE8-dihe-in -113.91, 113.67 APE8-rot-in 310.6 APE67-dihe-in -63.34, -18.99 -40.46, -50.32 APE12-dist-in 9.7898 APE11-dist-in 11.7618 APE10-dist-in 6.3647 APE9-dist-in 3.8778 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.34 0.207 0.228 B 301.0 283.0 16 30 25 5 [[183, 456]] 1.0 5t1t TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5T1TC Q9NWZ3 164 460 460.0 76P:9901 Type1 Inactive DFGin 6.9305 13.9526 BLAminus -133.8, 176.71 66.9, 81.1 -106.8, 16.35 308.8, 92.24 -64.12, -32.99 in-out in 8.9406 Saltbr-out 4.7923 HRD-in -66.05, -49.3 74.35, -2.18 out-in-in SNCoii in-in ActLoopNT-in 2.7376 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.21, 158.83 APE9-dihe-na 129.01, -170.01 APE8-dihe-in -113.41, 113.59 APE8-rot-in 310.43 APE67-dihe-in -64.34, -19.05 -39.55, -50.27 APE12-dist-in 9.7346 APE11-dist-in 11.7787 APE10-dist-in 6.3763 APE9-dist-in 3.8759 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.34 0.207 0.228 C 301.0 289.0 8 30 26 4 [[183, 456]] 1.0 5t1t TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5T1TD Q9NWZ3 164 459 460.0 76P:9901 Type1 Inactive DFGin 6.9694 13.9993 BLAminus -132.86, 176.93 67.54, 80.5 -108.06, 15.43 309.35, 93.29 -64.49, -32.38 in-out in 9.0752 Saltbr-out 4.2903 HRD-in -67.54, -50.03 76.03, -1.74 out-in-in SNCoii in-in ActLoopNT-in 2.7479 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.33, 157.65 APE9-dihe-na 129.81, -169.72 APE8-dihe-in -114.04, 113.72 APE8-rot-in 310.35 APE67-dihe-in -63.86, -17.96 -40.26, -50.55 APE12-dist-in 9.7798 APE11-dist-in 11.755 APE10-dist-in 6.3701 APE9-dist-in 3.8974 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.34 0.207 0.228 D 301.0 286.0 10 30 25 5 [[183, 456]] 1.0 5t1t TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4Y73A Q9NWZ3 163 459 460.0 XPY:1000 Type1 Inactive DFGin 6.7939 13.8816 BLAminus -135.22, 179.14 58.81, 74.84 -95.42, 16.11 309.59, 98.19 -56.86, -31.3 in-out in 8.6719 Saltbr-out 4.1966 HRD-in -65.11, -54.01 76.65, -4.03 out-in-in SNCoii in-in ActLoopNT-in 2.7411 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.98, 155.58 APE9-dihe-na 135.26, -172.46 APE8-dihe-in -110.18, 112.73 APE8-rot-in 310.78 APE67-dihe-in -61.03, -19.56 -40.26, -54.06 APE12-dist-in 10.1174 APE11-dist-in 11.6957 APE10-dist-in 6.3615 APE9-dist-in 4.0109 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.14 0.196 0.217 A 302.0 292.0 5 30 25 5 [[183, 456]] 1.0 4y73 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4Y73B Q9NWZ3 161 459 460.0 XPY:1000 Type1 Inactive DFGin 6.9031 13.8994 BLAminus -134.53, 179.53 58.2, 75.65 -95.32, 17.24 309.95, 97.89 -59.17, -23.79 in-out in 8.3394 Saltbr-out 3.7399 HRD-in -64.75, -51.42 74.08, -3.62 out-in-in SNCoii in-in ActLoopNT-in 2.8588 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.97, 155.19 APE9-dihe-na 135.01, -173.41 APE8-dihe-in -108.72, 112.77 APE8-rot-in 310.3 APE67-dihe-in -60.51, -19.8 -41.06, -53.91 APE12-dist-in 10.1439 APE11-dist-in 11.7409 APE10-dist-in 6.3534 APE9-dist-in 3.9692 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.14 0.196 0.217 B 302.0 292.0 7 30 23 7 [[183, 456]] 1.0 4y73 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4Y73C Q9NWZ3 164 460 460.0 XPY:1000 Type1 Inactive DFGin 6.9893 13.7959 BLAminus -135.91, 178.91 60.18, 74.45 -95.65, 17.31 309.71, 99.32 -57.1, -32.23 in-out in 8.4949 Saltbr-out 4.0135 HRD-in -67.33, -52.41 76.27, -4.09 out-in-in SNCoii in-in ActLoopNT-in 2.752 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.79, 155.49 APE9-dihe-na 134.48, -173.93 APE8-dihe-in -109.04, 112.55 APE8-rot-in 310.08 APE67-dihe-in -60.39, -19.29 -39.87, -53.77 APE12-dist-in 10.0164 APE11-dist-in 11.817 APE10-dist-in 6.4291 APE9-dist-in 3.9704 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.14 0.196 0.217 C 302.0 293.0 4 30 26 4 [[183, 456]] 1.0 4y73 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6MOMB Q9NWZ3 164 459 460.0 JX4:500 Type1 Inactive DFGin 7.1655 13.5154 BLAminus -127.54, 170.46 71.09, 82.13 -106.22, 20.82 305.71, 89.03 -65.5, -27.27 in-out in 8.5492 Saltbr-out 5.0881 HRD-in -79.93, -51.42 76.22, 2.24 out-in-in SNCoii in-in ActLoopNT-in 2.7756 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.82, 152.75 APE9-dihe-na 140.22, 179.97 APE8-dihe-in -102.97, 112.18 APE8-rot-in 307.34 APE67-dihe-in -63.75, -15.14 -58.52, -34.89 APE12-dist-in 10.1297 APE11-dist-in 12.031 APE10-dist-in 7.0099 APE9-dist-in 4.5624 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.168 0.207 B 303.0 289.0 7 30 26 4 [[183, 456]] 1.0 6mom TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6MOMD Q9NWZ3 164 459 460.0 JX4:500 Type1 Inactive DFGin 6.9958 13.418 BLAminus -130.88, 172.79 70.38, 81.05 -105.81, 20.52 305.57, 94.51 -64.31, -26.67 in-out in 8.4879 Saltbr-out 4.6811 HRD-in -80.85, -51.58 75.47, 1.68 out-in-in SNCoii in-in ActLoopNT-in 2.8054 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.31, 153.05 APE9-dihe-na 140.98, -178.81 APE8-dihe-in -101.12, 113.96 APE8-rot-in 309.17 APE67-dihe-in -64.74, -14.89 -58.96, -36.24 APE12-dist-in 10.1507 APE11-dist-in 11.959 APE10-dist-in 7.0419 APE9-dist-in 4.5456 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.168 0.207 D 303.0 296.0 0 30 30 0 [[183, 456]] 1.0 6mom TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 9NA2A Q9NWZ3 164 458 460.0 A1BW0:501 Type1 Inactive DFGin 6.8477 13.7307 BLAminus -129.5, 174.15 76.19, 82.37 -109.93, 12.46 306.46, 102.0 -68.06, -20.21 in-out in 8.946 Saltbr-out 6.2888 HRD-in -77.12, -53.15 78.59, 0.07 out-in-in SNCoii in-in ActLoopNT-in 2.704 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.31, 156.05 APE9-dihe-na 126.63, -176.29 APE8-dihe-in -108.96, 120.82 APE8-rot-in 296.98 APE67-dihe-in -64.68, -11.03 -61.41, -36.62 APE12-dist-in 9.905 APE11-dist-in 11.9527 APE10-dist-in 6.5317 APE9-dist-in 4.4021 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.99 0.206 0.246 A 304.0 293.0 2 30 28 2 [[183, 456]] 1.0 9na2 TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 9NA2B Q9NWZ3 165 458 460.0 A1BW0:501 Type1 Inactive DFGin 6.9241 14.1302 BLAminus -134.63, 174.5 75.73, 83.38 -111.23, 11.86 301.94, 95.06 -63.77, -21.44 in-out in 8.971 Saltbr-out 6.13 HRD-in -76.54, -51.75 76.66, 1.42 out-in-in SNCoii in-in ActLoopNT-in 2.6237 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.09, 160.31 APE9-dihe-na 114.91, -171.81 APE8-dihe-in -114.31, 117.82 APE8-rot-in 292.46 APE67-dihe-in -63.01, -16.36 -51.36, -43.64 APE12-dist-in 10.1486 APE11-dist-in 11.9934 APE10-dist-in 6.6007 APE9-dist-in 4.4889 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.99 0.206 0.246 B 304.0 287.0 7 30 25 5 [[183, 456]] 1.0 9na2 TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 9NA5A Q9NWZ3 162 458 460.0 A1BWY:501 Type1 Inactive DFGin 6.8573 13.7953 BLAminus -133.26, 171.01 69.04, 85.7 -105.99, 16.7 310.03, 99.89 -62.7, -22.3 in-out in 8.8572 Saltbr-out 4.4238 HRD-in -75.21, -50.97 79.25, -1.48 out-in-in SNCoii in-in ActLoopNT-in 2.6791 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.97, 159.53 APE9-dihe-na 136.23, -177.51 APE8-dihe-in -108.28, 116.32 APE8-rot-in 306.12 APE67-dihe-in -69.45, -13.91 -54.86, -39.45 APE12-dist-in 10.4537 APE11-dist-in 11.8359 APE10-dist-in 6.49 APE9-dist-in 3.958 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.73 0.19 0.227 A 304.0 291.0 6 30 26 4 [[183, 456]] 1.0 9na5 TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 9NA5B Q9NWZ3 165 458 460.0 A1BWY:501 Type1 Inactive DFGin 6.876 13.9226 BLAminus -130.74, 172.07 71.17, 82.18 -107.01, 16.94 308.3, 95.76 -65.86, -22.74 in-out in 8.8818 Saltbr-out 4.1971 HRD-in -71.92, -49.38 75.44, -3.18 out-in-in SNCoii in-in ActLoopNT-in 2.6831 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.98, 162.05 APE9-dihe-na 124.64, -175.69 APE8-dihe-in -110.28, 114.32 APE8-rot-in 308.49 APE67-dihe-in -65.45, -14.65 -45.32, -47.37 APE12-dist-in 10.2616 APE11-dist-in 12.1034 APE10-dist-in 6.6156 APE9-dist-in 4.2001 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.73 0.19 0.227 B 304.0 284.0 10 30 26 4 [[183, 456]] 1.0 9na5 TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 9NA5C Q9NWZ3 161 458 460.0 A1BWY:501 Type1 Inactive DFGin 6.8473 13.8139 BLAminus -130.66, 174.72 69.96, 81.61 -104.57, 15.46 307.74, 101.68 -63.81, -23.82 in-out in 8.9007 Saltbr-out 5.866 HRD-in -74.06, -49.12 75.91, 0.34 out-in-in SNCoii in-in ActLoopNT-in 2.6928 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.19, 157.89 APE9-dihe-na 134.71, -176.93 APE8-dihe-in -111.25, 115.39 APE8-rot-in 313.06 APE67-dihe-in -67.61, -11.6 -53.8, -44.56 APE12-dist-in 10.3174 APE11-dist-in 11.8345 APE10-dist-in 6.4403 APE9-dist-in 4.0253 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.73 0.19 0.227 C 304.0 291.0 7 30 25 5 [[183, 456]] 1.0 9na5 TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 9NA5D Q9NWZ3 164 458 460.0 A1BWY:501 Type1 Inactive DFGin 6.9561 13.9047 BLAminus -133.93, 172.24 67.87, 81.49 -104.77, 16.45 307.07, 100.09 -65.52, -27.63 in-out in 8.6953 Saltbr-out 4.3303 HRD-in -70.04, -49.46 77.38, -3.43 out-in-in SNCoii in-in ActLoopNT-in 2.7008 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.14, 158.61 APE9-dihe-na 129.07, -176.96 APE8-dihe-in -107.72, 113.83 APE8-rot-in 313.13 APE67-dihe-in -66.94, -16.69 -45.61, -45.94 APE12-dist-in 10.2273 APE11-dist-in 12.0281 APE10-dist-in 6.5641 APE9-dist-in 4.0674 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.73 0.19 0.227 D 304.0 285.0 10 30 26 4 [[183, 456]] 1.0 9na5 TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 9NA6A Q9NWZ3 164 458 460.0 A1BWZ:501 Type1 Inactive DFGin 6.721 13.6876 BLAminus -137.72, 177.76 61.95, 81.18 -105.84, 21.75 314.25, 92.68 -68.32, -23.98 in-out in 8.8626 Saltbr-out 4.8157 HRD-in -69.93, -48.99 73.89, 7.21 out-in-in SNCoii in-in ActLoopNT-in 2.5351 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.84, 156.52 APE9-dihe-na 129.68, 177.66 APE8-dihe-in -93.15, 117.82 APE8-rot-in 311.66 APE67-dihe-in -64.52, -19.34 -62.24, -34.28 APE12-dist-in 10.4305 APE11-dist-in 11.758 APE10-dist-in 6.6341 APE9-dist-in 4.201 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.14 0.215 0.246 A 304.0 285.0 10 30 24 6 [[183, 456]] 1.0 9na6 TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 9NA6B Q9NWZ3 166 458 460.0 A1BWZ:501 Type1 Inactive DFGin 6.8899 13.6553 BLAminus -131.83, -177.82 57.71, 78.74 -101.25, 28.45 309.13, 97.45 -66.82, -49.29 in-out in 8.7208 Saltbr-out 4.4197 HRD-in -71.05, -48.89 69.34, 8.62 out-in-in SNCoii in-in ActLoopNT-in 2.4766 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.78, 144.51 APE9-dihe-na 141.43, -168.74 APE8-dihe-in -110.53, 118.7 APE8-rot-in 308.86 APE67-dihe-in -63.4, -17.18 -58.15, -40.7 APE12-dist-in 10.2018 APE11-dist-in 11.9098 APE10-dist-in 6.4955 APE9-dist-in 4.2297 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.14 0.215 0.246 B 304.0 276.0 17 30 25 5 [[183, 456]] 1.0 9na6 TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 9NA6C Q9NWZ3 165 458 460.0 A1BWZ:501 Type1 Inactive DFGin 6.8296 13.8219 BLAminus -137.21, 175.52 61.39, 85.88 -109.71, 19.68 311.56, 94.94 -67.31, -23.31 in-out in 8.9623 Saltbr-out 4.2037 HRD-in -70.95, -51.5 74.46, 4.63 out-in-in SNCoii in-in ActLoopNT-in 2.6532 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.0, 159.33 APE9-dihe-na 132.78, -176.71 APE8-dihe-in -104.67, 119.95 APE8-rot-in 309.79 APE67-dihe-in -64.37, -16.17 -62.59, -40.04 APE12-dist-in 10.1583 APE11-dist-in 11.6635 APE10-dist-in 6.4426 APE9-dist-in 4.1281 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.14 0.215 0.246 C 304.0 286.0 8 30 25 5 [[183, 456]] 1.0 9na6 TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 9NA6D Q9NWZ3 165 458 460.0 A1BWZ:501 Type1 Inactive DFGin 6.9431 13.6177 BLAminus -133.67, 176.88 60.25, 73.83 -97.87, 24.38 314.47, 96.87 -71.99, -35.94 in-out in 8.7921 Saltbr-out 5.2844 HRD-in -66.69, -50.31 69.34, 8.63 out-in-in SNCoii in-in ActLoopNT-in 2.6485 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.39, 147.5 APE9-dihe-na 142.28, -170.25 APE8-dihe-in -108.07, 118.9 APE8-rot-in 310.29 APE67-dihe-in -66.51, -20.67 -56.64, -38.87 APE12-dist-in 10.1932 APE11-dist-in 11.7368 APE10-dist-in 6.4753 APE9-dist-in 4.3319 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.14 0.215 0.246 D 304.0 277.0 17 30 26 4 [[183, 456]] 1.0 9na6 TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6O8UA Q9NWZ3 164 458 460.0 LS7:501 Type1 Inactive DFGin 6.8496 13.9237 BLAminus -130.69, 173.07 63.01, 86.37 -108.36, 22.19 311.43, 95.51 -64.92, -32.76 in-out in 8.7449 Saltbr-out 5.5857 HRD-in -75.11, -49.45 74.88, -0.72 out-in-in SNCoii in-in ActLoopNT-in 2.8137 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.91, 157.66 APE9-dihe-na 128.13, 175.66 APE8-dihe-in -101.58, 115.34 APE8-rot-in 306.32 APE67-dihe-in -62.48, -19.12 -53.1, -39.45 APE12-dist-in 10.265 APE11-dist-in 11.8986 APE10-dist-in 6.3917 APE9-dist-in 3.9382 None TPO345,SEP346 TPO345,SEP346 XRAY 1.8 0.232 0.255 A 305.0 283.0 12 30 24 6 [[183, 456]] 1.0 6o8u TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6O8UB Q9NWZ3 160 458 460.0 LS7:501 Type1 Inactive DFGin 6.7464 14.3255 BLAminus -126.54, 176.56 64.22, 88.45 -115.23, 24.91 305.83, 84.08 -70.08, -44.03 in-out in 8.8874 Saltbr-out 4.6625 HRD-in -67.93, -50.14 73.94, 8.33 out-in-in SNCoii in-in ActLoopNT-in 2.8827 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.94, 156.88 APE9-dihe-na 130.39, -170.17 APE8-dihe-in -111.3, 117.6 APE8-rot-in 309.78 APE67-dihe-in -67.89, -15.82 -48.54, -45.93 APE12-dist-in 10.4025 APE11-dist-in 11.9103 APE10-dist-in 6.5663 APE9-dist-in 4.1608 None TPO345,SEP346 TPO345,SEP346 XRAY 1.8 0.232 0.255 B 305.0 286.0 13 30 23 7 [[183, 456]] 1.0 6o8u TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6O8UC Q9NWZ3 163 458 460.0 LS7:501 Type1 Inactive DFGin 6.7864 13.9031 BLAminus -128.29, 176.07 64.24, 85.11 -109.32, 20.81 312.79, 96.26 -63.76, -35.39 in-out in 8.9621 Saltbr-out 5.2152 HRD-in -75.57, -52.02 75.43, 8.91 out-in-in SNCoii in-in ActLoopNT-in 2.8058 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.09, 151.89 APE9-dihe-na 134.27, -175.85 APE8-dihe-in -100.31, 112.85 APE8-rot-in 307.74 APE67-dihe-in -64.12, -18.09 -55.7, -37.12 APE12-dist-in 9.9208 APE11-dist-in 12.0749 APE10-dist-in 7.1277 APE9-dist-in 4.8131 None TPO345,SEP346 TPO345,SEP346 XRAY 1.8 0.232 0.255 C 305.0 292.0 4 30 26 4 [[183, 456]] 1.0 6o8u TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6O8UD Q9NWZ3 162 458 460.0 LS7:501 Type1 Inactive DFGin 6.6865 13.956 BLAminus -123.57, 176.25 66.06, 85.61 -109.09, 18.14 308.14, 93.15 -62.5, -37.48 in-out in 9.0392 Saltbr-out 4.9797 HRD-in -73.18, -49.75 72.94, 10.03 out-in-in SNCoii in-in ActLoopNT-in 2.8474 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.37, 151.31 APE9-dihe-na 137.68, -175.61 APE8-dihe-in -104.71, 113.88 APE8-rot-in 306.99 APE67-dihe-in -63.19, -22.97 -60.18, -27.94 APE12-dist-in 9.9588 APE11-dist-in 11.8343 APE10-dist-in 6.9077 APE9-dist-in 4.6584 None TPO345,SEP346 TPO345,SEP346 XRAY 1.8 0.232 0.255 D 305.0 290.0 7 30 24 6 [[183, 456]] 1.0 6o8u TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5W85A Q9NWZ3 164 458 460.0 9YS:4000 Type1 Inactive DFGin 6.813 14.8006 BLAminus -119.69, 174.7 62.24, 92.17 -111.46, 11.32 305.63, 96.72 -63.25, -31.58 in-out in 8.9015 Saltbr-out 6.0751 HRD-in -63.97, -52.63 78.83, -4.43 out-in-in SNCoii in-in ActLoopNT-in 2.712 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.53, 155.64 APE9-dihe-na 132.02, -173.09 APE8-dihe-in -113.06, 114.4 APE8-rot-in 314.94 APE67-dihe-in -58.27, -22.42 -43.08, -51.51 APE12-dist-in 10.7433 APE11-dist-in 11.6775 APE10-dist-in 6.2108 APE9-dist-in 3.7715 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.25 0.227 0.251 A 305.0 281.0 14 30 25 5 [[183, 456]] 1.0 5w85 TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5W85B Q9NWZ3 164 459 460.0 9YS:4000 Type1 Inactive DFGin 6.7637 14.8223 BLAminus -118.77, 174.95 63.48, 91.76 -111.27, 11.84 305.7, 96.65 -62.41, -32.37 in-out in 8.9394 Saltbr-out 6.4178 HRD-in -63.31, -52.79 78.17, -3.31 out-in-in SNCoii in-in ActLoopNT-in 2.711 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.8, 156.56 APE9-dihe-na 131.61, -171.93 APE8-dihe-in -111.44, 113.82 APE8-rot-in 314.64 APE67-dihe-in -58.18, -22.16 -43.05, -51.43 APE12-dist-in 10.6394 APE11-dist-in 11.7542 APE10-dist-in 6.2542 APE9-dist-in 3.7207 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.25 0.227 0.251 B 305.0 282.0 14 30 26 4 [[183, 456]] 1.0 5w85 TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6LXYA Q9NWZ3 163 458 460.0 EXF:501 Type1 Inactive DFGin 6.9967 14.0491 BLAminus -130.85, 177.02 62.25, 85.69 -105.57, 13.21 307.3, 97.03 -58.17, -30.36 in-out in 8.9293 Saltbr-out 5.3622 HRD-in -67.47, -54.1 77.02, 0.48 out-in-in SNCoii in-in ActLoopNT-in 2.8192 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.95, 147.66 APE9-dihe-na 135.07, -175.38 APE8-dihe-in -106.14, 112.07 APE8-rot-in 312.29 APE67-dihe-in -59.29, -20.88 -52.35, -43.4 APE12-dist-in 10.1915 APE11-dist-in 11.7043 APE10-dist-in 6.4389 APE9-dist-in 4.3573 None TPO345,SEP346 TPO345,SEP346 XRAY 2.19 0.202 0.231 A 305.0 294.0 2 30 28 2 [[183, 456]] 1.0 6lxy TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6LXYD Q9NWZ3 162 459 460.0 EXF:502 Type1 Inactive DFGin 7.0024 14.1156 BLAminus -130.62, 177.55 62.4, 85.91 -106.35, 12.8 307.19, 98.16 -58.64, -30.18 in-out in 8.9428 Saltbr-out 5.3537 HRD-in -67.38, -53.42 77.14, -1.48 out-in-in SNCoii in-in ActLoopNT-in 2.7863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.01, 149.8 APE9-dihe-na 134.89, -175.28 APE8-dihe-in -104.95, 111.45 APE8-rot-in 311.34 APE67-dihe-in -58.57, -21.72 -44.58, -48.25 APE12-dist-in 10.314 APE11-dist-in 11.9545 APE10-dist-in 6.613 APE9-dist-in 4.2536 None TPO345,SEP346 TPO345,SEP346 XRAY 2.19 0.202 0.231 D 305.0 293.0 5 30 25 5 [[183, 456]] 1.0 6lxy TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6LXYE Q9NWZ3 164 458 460.0 EXF:502 Type1 Inactive DFGin 6.9536 14.1587 BLAminus -130.3, 176.57 62.62, 85.73 -105.89, 13.23 306.79, 97.59 -58.45, -29.69 in-out in 8.9309 Saltbr-out 5.3907 HRD-in -66.96, -52.89 76.03, -0.37 out-in-in SNCoii in-in ActLoopNT-in 2.7953 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.25, 150.73 APE9-dihe-na 134.77, -173.9 APE8-dihe-in -105.72, 111.9 APE8-rot-in 311.85 APE67-dihe-in -56.93, -22.86 -45.56, -48.25 APE12-dist-in 10.3091 APE11-dist-in 11.9048 APE10-dist-in 6.6072 APE9-dist-in 4.2918 None TPO345,SEP346 TPO345,SEP346 XRAY 2.19 0.202 0.231 E 305.0 288.0 7 30 23 7 [[183, 456]] 1.0 6lxy TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6VQLA Q9NWZ3 162 458 460.0 R7S:501 Type1 Inactive DFGin 6.9484 14.1016 BLAminus -128.89, 178.86 62.54, 89.32 -112.77, 19.41 307.7, 95.35 -67.01, -28.48 in-out in 8.8675 Saltbr-out 5.76 HRD-in -60.86, -51.23 73.74, 13.24 out-in-in SNCoii in-in ActLoopNT-in 2.8492 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.6, 156.29 APE9-dihe-na 133.29, -167.61 APE8-dihe-in -110.06, 117.8 APE8-rot-in 304.32 APE67-dihe-in -57.05, -22.07 -48.75, -46.61 APE12-dist-in 10.1761 APE11-dist-in 11.8072 APE10-dist-in 6.649 APE9-dist-in 4.2808 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.069 0.244 0.279 A 305.0 289.0 8 30 24 6 [[183, 456]] 1.0 6vql TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6VQLB Q9NWZ3 163 458 460.0 R7S:501 Type1 Inactive DFGin 6.8966 14.2148 BLAminus -126.69, 171.91 63.96, 89.58 -112.73, 19.19 306.74, 94.98 -66.69, -28.16 in-out in 8.9822 Saltbr-out 5.741 HRD-in -62.48, -51.55 75.13, -0.71 out-in-in SNCoii in-in ActLoopNT-in 2.8406 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.85, 155.05 APE9-dihe-na 137.23, -167.23 APE8-dihe-in -108.71, 118.9 APE8-rot-in 303.04 APE67-dihe-in -58.51, -22.41 -49.11, -44.93 APE12-dist-in 9.9848 APE11-dist-in 11.6612 APE10-dist-in 6.4733 APE9-dist-in 4.1617 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.069 0.244 0.279 B 305.0 286.0 10 30 24 6 [[183, 456]] 1.0 6vql TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6VQLC Q9NWZ3 163 458 460.0 R7S:501 Type1 Inactive DFGin 6.8553 14.2188 BLAminus -132.18, 176.88 62.56, 88.49 -111.96, 18.83 307.92, 94.58 -68.15, -27.83 in-out in 8.914 Saltbr-out 5.6384 HRD-in -60.2, -52.63 76.62, 2.47 out-in-in SNCoii in-in ActLoopNT-in 2.8512 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.63, 152.97 APE9-dihe-na 134.77, -170.05 APE8-dihe-in -109.39, 118.28 APE8-rot-in 304.2 APE67-dihe-in -58.39, -21.83 -47.95, -45.47 APE12-dist-in 10.3271 APE11-dist-in 11.87 APE10-dist-in 6.6051 APE9-dist-in 4.1155 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.069 0.244 0.279 C 305.0 287.0 9 30 26 4 [[183, 456]] 1.0 6vql TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6VQLD Q9NWZ3 164 458 460.0 R7S:501 Type1 Inactive DFGin 6.8992 14.2157 BLAminus -132.06, 177.07 63.58, 87.81 -112.09, 19.53 307.29, 95.54 -67.51, -28.65 in-out in 8.8824 Saltbr-out 5.7951 HRD-in -61.98, -52.71 76.16, 3.96 out-in-in SNCoii in-in ActLoopNT-in 2.8477 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.0, 154.7 APE9-dihe-na 133.81, -169.11 APE8-dihe-in -109.98, 117.79 APE8-rot-in 303.11 APE67-dihe-in -57.87, -22.08 -46.74, -46.13 APE12-dist-in 10.0605 APE11-dist-in 11.8494 APE10-dist-in 6.607 APE9-dist-in 4.1195 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.069 0.244 0.279 D 305.0 287.0 8 30 27 3 [[183, 456]] 1.0 6vql TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8SCEA Q9NWZ3 164 459 460.0 ZVD:501 Type1 Inactive DFGin 6.8097 14.0165 BLAminus -126.47, -178.7 59.91, 82.58 -102.13, 13.59 306.65, 101.09 -59.02, -31.96 in-out in 8.9343 Saltbr-out 3.9405 HRD-in -69.45, -51.74 77.12, -3.19 out-in-in SNCoii in-in ActLoopNT-in 2.7833 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.78, 152.45 APE9-dihe-na 139.2, -169.88 APE8-dihe-in -111.37, 109.73 APE8-rot-in 310.53 APE67-dihe-in -61.52, -17.0 -52.93, -40.4 APE12-dist-in 10.3682 APE11-dist-in 11.7487 APE10-dist-in 6.5372 APE9-dist-in 4.2328 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.89 0.204 0.228 A 305.0 286.0 10 30 25 5 [[183, 456]] 1.0 8sce TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8SCVB Q9NWZ3 165 459 460.0 ZVG:501 Type1 Inactive DFGin 7.1982 14.2281 BLAminus -124.98, -179.77 59.41, 86.09 -112.04, 18.78 306.72, 95.85 -65.24, -40.99 in-none in 8.6641 Saltbr-none 999.0 HRD-in -71.15, -45.18 73.66, -10.79 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aannn APEdist_ooon APE10-dihe-na -17.19, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -60.41, -44.69 999.0, 171.91 APE12-dist-out 20.2582 APE11-dist-out 21.893 APE10-dist-out 16.6393 APE9-dist-none 999.0 None TPO345,SEP346 TPO345,SEP346 XRAY 2.69 0.222 0.261 B 305.0 263.0 32 30 19 11 [[183, 456]] 1.0 8scv TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 2NRUA Q9NWZ3 164 458 460.0 T12:600 Type1 Inactive DFGin 6.8099 14.2068 BLAminus -144.52, 176.61 61.01, 85.78 -109.02, 12.36 305.24, 99.64 -69.12, -13.83 in-out in 8.9452 Saltbr-out 4.7125 HRD-in -72.42, -46.16 74.2, -6.12 out-in-in SNCoii in-in ActLoopNT-in 2.7294 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.65, 155.19 APE9-dihe-na 137.29, -171.31 APE8-dihe-in -118.15, 118.79 APE8-rot-in 298.95 APE67-dihe-in -68.17, -16.18 -56.18, -39.45 APE12-dist-in 9.9818 APE11-dist-in 12.0247 APE10-dist-in 6.3558 APE9-dist-in 3.6872 None TPO345,SEP346 TPO345,SEP346 XRAY 2.0 0.237 0.299 A 307.0 295.0 0 30 30 0 [[183, 456]] 1.0 2nru TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 2NRUB Q9NWZ3 163 458 460.0 T12:601 Type1 Inactive DFGin 6.9604 14.2106 BLAminus -137.22, 177.45 63.67, 76.5 -99.31, 24.17 313.64, 91.89 -66.38, -18.79 in-out in 8.9606 Saltbr-out 4.8485 HRD-in -79.32, -50.69 82.23, -1.29 out-in-in SNCoii in-in ActLoopNT-in 2.7826 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.97, 154.3 APE9-dihe-na 141.66, -169.29 APE8-dihe-in -112.44, 117.57 APE8-rot-in 305.42 APE67-dihe-in -56.19, -21.78 -44.47, -53.99 APE12-dist-in 10.0872 APE11-dist-in 11.8736 APE10-dist-in 6.2572 APE9-dist-in 3.7879 None TPO345,SEP346 TPO345,SEP346 XRAY 2.0 0.237 0.299 B 307.0 296.0 0 30 30 0 [[183, 456]] 1.0 2nru TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 2NRUC Q9NWZ3 164 458 460.0 T12:602 Type1 Inactive DFGin 6.8622 14.0444 BLAminus -133.27, -178.43 54.04, 81.31 -99.32, 21.09 309.78, 92.94 -44.33, -46.49 in-out in 9.1783 Saltbr-out 6.0489 HRD-in -65.42, -50.47 80.21, -0.92 out-in-in SNCoii in-in ActLoopNT-in 2.6841 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.9, 149.98 APE9-dihe-na 140.03, -170.94 APE8-dihe-in -117.58, 117.62 APE8-rot-in 307.34 APE67-dihe-in -53.9, -13.95 -48.73, -50.48 APE12-dist-in 9.9887 APE11-dist-in 11.9789 APE10-dist-in 6.1763 APE9-dist-in 3.6513 None TPO345,SEP346 TPO345,SEP346 XRAY 2.0 0.237 0.299 C 307.0 295.0 0 30 30 0 [[183, 456]] 1.0 2nru TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 2NRUD Q9NWZ3 164 458 460.0 T12:603 Type1 Inactive DFGin 6.9472 14.0982 BLAminus -135.72, 173.17 70.19, 87.19 -107.97, 13.86 307.81, 96.43 -64.39, -20.58 in-out in 9.1072 Saltbr-out 4.4888 HRD-in -69.73, -51.3 77.25, -2.09 out-in-in SNCoii in-in ActLoopNT-in 2.6621 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.08, 159.59 APE9-dihe-na 136.7, -170.84 APE8-dihe-in -116.97, 119.52 APE8-rot-in 299.39 APE67-dihe-in -65.53, -15.07 -56.41, -37.98 APE12-dist-in 9.9199 APE11-dist-in 11.8549 APE10-dist-in 6.2692 APE9-dist-in 3.6063 None TPO345,SEP346 TPO345,SEP346 XRAY 2.0 0.237 0.299 D 307.0 295.0 0 30 30 0 [[183, 456]] 1.0 2nru TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4RMZA Q9NWZ3 165 458 460.0 T20:501 Type1 Inactive DFGin 6.9177 13.9891 BLAminus -126.68, 170.9 71.61, 84.5 -108.32, 13.5 307.27, 99.22 -63.08, -23.58 in-out in 9.2564 Saltbr-out 5.0284 HRD-in -71.37, -54.68 82.53, 0.08 out-in-in SNCoii in-in ActLoopNT-in 2.6851 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.07, 154.46 APE9-dihe-na 140.89, -175.55 APE8-dihe-in -107.53, 124.9 APE8-rot-in 311.29 APE67-dihe-in -64.19, -16.01 -66.65, -36.99 APE12-dist-in 10.1681 APE11-dist-in 11.8109 APE10-dist-in 6.8502 APE9-dist-in 3.935 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.2 0.239 0.296 A 307.0 287.0 7 30 27 3 [[183, 456]] 1.0 4rmz TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4RMZB Q9NWZ3 165 458 460.0 T20:501 Type1 Inactive DFGin 6.6818 13.8372 BLAminus -127.34, 178.11 67.71, 81.3 -107.41, 14.46 311.78, 87.68 -59.65, -35.76 in-out in 9.1851 Saltbr-out 4.3576 HRD-in -77.65, -51.27 81.38, -11.53 out-in-in SNCoii in-in ActLoopNT-in 2.8032 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.02, 148.94 APE9-dihe-na 142.43, 179.5 APE8-dihe-in -98.65, 120.34 APE8-rot-in 323.49 APE67-dihe-in -67.37, -15.66 -55.22, -41.75 APE12-dist-in 10.2326 APE11-dist-in 12.0489 APE10-dist-in 6.7697 APE9-dist-in 4.476 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.2 0.239 0.296 B 307.0 284.0 10 30 24 6 [[183, 456]] 1.0 4rmz TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8TVMA Q9NWZ3 164 459 460.0 VDC:501 Type1 Inactive DFGin 7.0501 14.4498 BLAminus -132.18, 174.07 62.0, 72.94 -94.59, 26.48 308.28, 71.42 -66.42, -36.15 in-out in 9.0051 Saltbr-out 4.39 HRD-in -66.24, -53.38 76.43, -3.48 out-in-in SNCoii in-in ActLoopNT-in 2.6755 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.69, 149.04 APE9-dihe-na 147.68, -173.36 APE8-dihe-in -109.64, 107.78 APE8-rot-in 317.11 APE67-dihe-in -64.75, -17.49 -53.67, -37.13 APE12-dist-in 9.854 APE11-dist-in 11.9108 APE10-dist-in 6.7173 APE9-dist-in 4.1363 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.223 0.246 A 307.0 287.0 9 30 25 5 [[183, 456]] 1.0 8tvm TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8TVNB Q9NWZ3 164 459 460.0 VE9:501 Type1 Inactive DFGin 6.6028 14.4763 BLAminus -131.79, -173.84 61.55, 70.77 -94.0, 17.31 300.61, 97.59 -62.64, -29.8 in-out in 9.1406 Saltbr-out 4.7146 HRD-in -66.97, -49.93 68.76, 1.62 out-in-in SNCoii in-in ActLoopNT-in 2.9298 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.69, 158.15 APE9-dihe-na 141.52, -174.1 APE8-dihe-in -109.0, 120.89 APE8-rot-in 302.22 APE67-dihe-in -68.04, -9.84 -64.13, -33.08 APE12-dist-in 10.3621 APE11-dist-in 11.6165 APE10-dist-in 6.1182 APE9-dist-in 3.6145 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.95 0.208 0.242 B 307.0 286.0 10 30 24 6 [[183, 456]] 1.0 8tvn TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8TVNC Q9NWZ3 164 458 460.0 VE9:501 Type1 Inactive DFGin 6.8157 14.2711 BLAminus -134.87, -179.71 63.14, 78.0 -99.07, 16.75 311.05, 99.83 -68.52, -20.84 in-out in 8.9656 Saltbr-out 7.9858 HRD-in -73.64, -49.44 78.87, -3.37 out-in-in SNCoii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.92, 162.63 APE9-dihe-na 133.65, -178.49 APE8-dihe-in -106.73, 121.01 APE8-rot-in 304.08 APE67-dihe-in -68.08, -14.0 -59.46, -35.34 APE12-dist-in 10.0153 APE11-dist-in 11.7731 APE10-dist-in 6.3704 APE9-dist-in 3.7637 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.95 0.208 0.242 C 307.0 286.0 9 30 24 6 [[183, 456]] 1.0 8tvn TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8TX0A Q9NWZ3 164 459 460.0 VEU:501 Type1 Inactive DFGin 6.7893 13.9204 BLAminus -129.73, 176.59 65.6, 77.23 -99.3, 19.02 315.24, 98.72 -60.81, -34.53 in-out in 8.826 Saltbr-out 5.8696 HRD-in -69.7, -48.85 75.81, -2.36 out-in-in SNCoii in-in ActLoopNT-in 2.6468 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.63, 157.0 APE9-dihe-na 131.18, -179.13 APE8-dihe-in -106.66, 116.14 APE8-rot-in 293.2 APE67-dihe-in -65.42, -13.38 -58.15, -40.41 APE12-dist-in 9.8637 APE11-dist-in 11.8077 APE10-dist-in 6.5529 APE9-dist-in 4.2168 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.0 0.208 0.238 A 307.0 286.0 10 30 25 5 [[183, 456]] 1.0 8tx0 TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8TX0B Q9NWZ3 164 459 460.0 VEU:501 Type1 Inactive DFGin 6.8379 14.2966 BLAminus -129.72, 178.54 65.66, 76.17 -98.39, 13.53 305.13, 94.22 -63.2, -26.14 in-out in 9.2869 Saltbr-out 4.5523 HRD-in -70.22, -48.33 73.47, 0.05 out-in-in SNCoii in-in ActLoopNT-in 2.7242 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.02, 152.76 APE9-dihe-na 138.77, -175.43 APE8-dihe-in -104.24, 111.09 APE8-rot-in 310.05 APE67-dihe-in -64.51, -18.26 -47.53, -45.01 APE12-dist-in 9.9994 APE11-dist-in 12.0054 APE10-dist-in 7.0902 APE9-dist-in 4.8138 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.0 0.208 0.238 B 307.0 292.0 4 30 26 4 [[183, 456]] 1.0 8tx0 TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8UCBA Q9NWZ3 164 459 460.0 X1T:501 Type1 Inactive DFGin 6.5864 13.5726 BLAminus -133.38, -177.12 64.35, 68.66 -97.8, 16.07 315.98, 102.93 -65.68, -24.73 in-out in 8.6022 Saltbr-out 4.6911 HRD-in -74.88, -51.2 76.87, -1.43 out-in-in SNCoii in-in ActLoopNT-in 2.7607 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.62, 153.75 APE9-dihe-na 131.02, 179.21 APE8-dihe-in -98.2, 123.02 APE8-rot-in 308.0 APE67-dihe-in -65.09, -13.5 -58.01, -44.66 APE12-dist-in 10.2847 APE11-dist-in 12.061 APE10-dist-in 6.9488 APE9-dist-in 4.5201 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.85 0.209 0.243 A 307.0 289.0 7 30 26 4 [[183, 456]] 1.0 8ucb TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8UCBB Q9NWZ3 164 459 460.0 X1T:501 Type1 Inactive DFGin 6.6068 13.6491 BLAminus -133.65, -177.71 64.73, 70.02 -96.46, 15.08 312.24, 106.62 -64.34, -23.76 in-out in 8.4707 Saltbr-out 4.4017 HRD-in -75.17, -52.58 77.06, -2.05 out-in-in SNCoii in-in ActLoopNT-in 2.7252 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.68, 152.68 APE9-dihe-na 139.38, -177.32 APE8-dihe-in -102.85, 112.84 APE8-rot-in 315.95 APE67-dihe-in -69.47, -15.98 -65.94, -25.77 APE12-dist-in 10.0344 APE11-dist-in 12.218 APE10-dist-in 7.2634 APE9-dist-in 4.5061 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.85 0.209 0.243 B 307.0 288.0 8 30 24 6 [[183, 456]] 1.0 8ucb TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8UCBC Q9NWZ3 164 459 460.0 X1T:501 Type1 Inactive DFGin 6.8619 13.6822 BLAminus -134.97, -176.91 65.3, 70.16 -98.18, 15.85 309.36, 103.91 -62.86, -30.38 in-out in 8.58 Saltbr-out 4.6734 HRD-in -73.7, -52.09 76.17, -2.4 out-in-in SNCoii in-in ActLoopNT-in 2.7491 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.82, 155.19 APE9-dihe-na 136.02, -175.98 APE8-dihe-in -107.53, 111.71 APE8-rot-in 310.29 APE67-dihe-in -67.32, -13.57 -61.09, -32.68 APE12-dist-in 10.0286 APE11-dist-in 11.8791 APE10-dist-in 6.6271 APE9-dist-in 4.3453 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.85 0.209 0.243 C 307.0 287.0 9 30 24 6 [[183, 456]] 1.0 8ucb TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8UCBD Q9NWZ3 163 459 460.0 X1T:501 Type1 Inactive DFGin 6.6554 13.7707 BLAminus -133.17, -176.75 64.27, 71.56 -97.28, 15.93 311.73, 106.12 -63.94, -30.66 in-out in 8.6256 Saltbr-out 4.5655 HRD-in -70.95, -49.5 72.68, -1.18 out-in-in SNCoii in-in ActLoopNT-in 2.6741 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.88, 149.05 APE9-dihe-na 123.76, 174.28 APE8-dihe-in -91.74, 123.53 APE8-rot-in 308.1 APE67-dihe-in -62.24, -18.02 -60.37, -40.94 APE12-dist-in 10.2039 APE11-dist-in 11.968 APE10-dist-in 6.4738 APE9-dist-in 4.435 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.85 0.209 0.243 D 307.0 291.0 6 30 25 5 [[183, 456]] 1.0 8ucb TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8UCCA Q9NWZ3 160 459 460.0 WFQ:501 Type1 Inactive DFGin 7.0259 14.6998 BLAminus -131.7, 179.12 66.11, 75.99 -100.65, 16.62 301.91, 97.83 -63.53, -20.26 in-out in 9.3909 Saltbr-out 5.6136 HRD-in -75.53, -47.51 77.1, -4.78 out-in-in SNCoii in-in ActLoopNT-in 2.6824 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.27, 158.69 APE9-dihe-na 128.46, -168.51 APE8-dihe-in -116.14, 113.09 APE8-rot-in 308.41 APE67-dihe-in -66.69, -15.41 -48.67, -44.93 APE12-dist-in 10.0268 APE11-dist-in 11.9409 APE10-dist-in 6.614 APE9-dist-in 4.0809 None TPO345,SEP346 TPO345,SEP346 XRAY 1.8 0.21 0.24 A 307.0 295.0 5 30 25 5 [[183, 456]] 1.0 8ucc TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8UCCB Q9NWZ3 164 458 460.0 WFQ:501 Type1 Inactive DFGin 6.8793 13.8721 BLAminus -129.51, 162.92 70.33, 79.94 -104.55, 23.09 318.21, 95.61 -62.87, -26.0 in-out in 8.7684 Saltbr-out 6.0166 HRD-in -75.0, -48.09 77.72, -4.06 out-in-in SNCoii in-in ActLoopNT-in 2.7395 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.42, 156.86 APE9-dihe-na 134.29, 179.4 APE8-dihe-in -111.9, 115.53 APE8-rot-in 300.81 APE67-dihe-in -63.49, -15.46 -50.92, -46.75 APE12-dist-in 9.9358 APE11-dist-in 11.9321 APE10-dist-in 6.4043 APE9-dist-in 3.8041 None TPO345 TPO345 XRAY 1.8 0.21 0.24 B 307.0 286.0 9 30 25 5 [[183, 456]] 1.0 8ucc TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6THWA Q9NWZ3 164 458 460.0 NBK:501 Type1 Inactive DFGin 6.8204 14.6137 BLAminus -123.66, 168.11 62.81, 82.82 -101.09, 19.87 307.94, 110.85 -62.52, -25.01 in-out in 9.344 Saltbr-out 4.8967 HRD-in -67.46, -50.06 75.47, -3.2 out-in-none SNCoin in-none ActLoopNT-in 2.7816 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -124.8, 166.47 APE9-dihe-na 126.73, -169.13 APE8-dihe-in -110.99, 111.83 APE8-rot-in 308.93 APE67-dihe-in -62.57, -16.11 -43.52, -47.59 APE12-dist-none 999.0 APE11-dist-in 11.9165 APE10-dist-in 6.5636 APE9-dist-in 3.7607 None None None XRAY 2.44 0.242 0.271 A 308.0 277.0 18 30 18 12 [[183, 456]] 1.0 6thw TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6THWB Q9NWZ3 164 458 460.0 NBK:501 Type1 Inactive DFGin 7.0858 14.4327 BLAminus -140.9, 170.15 72.18, 81.33 -104.48, 18.05 307.7, 105.04 -67.72, -34.78 in-out in 9.1622 Saltbr-out 6.8487 HRD-in -62.52, -55.9 78.39, -2.11 out-in-none SNCoin in-none ActLoopNT-in 2.6548 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -148.04, 150.43 APE9-dihe-na 154.2, -168.3 APE8-dihe-in -105.53, 110.29 APE8-rot-in 314.35 APE67-dihe-in -55.79, -22.17 -55.77, -37.55 APE12-dist-none 999.0 APE11-dist-in 11.5075 APE10-dist-in 6.9992 APE9-dist-in 4.133 None None None XRAY 2.44 0.242 0.271 B 308.0 281.0 14 30 19 11 [[183, 456]] 1.0 6thw TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6THXB Q9NWZ3 164 458 460.0 N9Z:501 Type1 Inactive DFGin 6.7832 14.5032 BLAminus -130.3, 173.53 69.43, 82.81 -102.19, 17.11 308.42, 101.98 -60.44, -37.77 in-out in 9.0557 Saltbr-out 6.7422 HRD-in -69.56, -52.62 80.33, -6.88 out-in-in SNCoii in-in ActLoopNT-in 2.7756 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.94, 145.34 APE9-dihe-na 147.73, -171.87 APE8-dihe-in -106.02, 110.0 APE8-rot-in 309.88 APE67-dihe-in -61.74, -18.4 -54.4, -36.6 APE12-dist-in 10.54 APE11-dist-in 11.7168 APE10-dist-in 6.4037 APE9-dist-in 4.1021 None TPO345,SEP346 TPO345,SEP346 XRAY 1.99 0.232 0.254 B 308.0 283.0 12 30 25 5 [[183, 456]] 1.0 6thx TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6THZB Q9NWZ3 164 458 460.0 NB5:501 Type1 Inactive DFGin 6.8838 14.4002 BLAminus -139.08, 176.87 64.46, 76.57 -96.2, 11.73 309.97, 94.63 -53.15, -40.13 in-out in 8.8775 Saltbr-out 7.0047 HRD-in -73.05, -47.74 74.11, -0.28 out-in-in SNCoii in-in ActLoopNT-in 2.79 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.96, 150.22 APE9-dihe-na 143.37, -165.81 APE8-dihe-in -109.46, 106.81 APE8-rot-in 312.76 APE67-dihe-in -65.57, -18.06 -35.96, -49.66 APE12-dist-in 10.5033 APE11-dist-in 11.8757 APE10-dist-in 6.7528 APE9-dist-in 4.1586 None TPO345,SEP346 TPO345,SEP346 XRAY 2.38 0.233 0.274 B 308.0 283.0 12 30 25 5 [[183, 456]] 1.0 6thz TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 7QG2A Q9NWZ3 164 458 460.0 B6I:501 Type1 Inactive DFGin 6.7297 14.1053 BLAminus -125.05, 176.88 61.14, 81.6 -102.86, 19.43 311.58, 97.65 -64.22, -24.25 in-out in 8.7049 Saltbr-out 4.5606 HRD-in -63.97, -47.98 75.86, -3.25 out-in-in SNCoii in-in ActLoopNT-in 2.8469 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.2, 151.19 APE9-dihe-na 136.66, 178.88 APE8-dihe-in -97.77, 114.51 APE8-rot-in 305.46 APE67-dihe-in -59.4, -19.06 -44.01, -48.1 APE12-dist-in 10.052 APE11-dist-in 11.4971 APE10-dist-in 6.1997 APE9-dist-in 3.9271 None TPO345,SEP346 TPO345,SEP346 XRAY 3.031 0.227 0.274 A 308.0 281.0 14 30 24 6 [[183, 456]] 1.0 7qg2 TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 7QG2B Q9NWZ3 165 458 460.0 B6I:501 Type1 Inactive DFGin 6.7217 14.5967 BLAminus -126.18, -179.5 55.73, 88.47 -114.93, 34.76 304.62, 86.87 -76.5, -21.59 in-out in 9.0083 Saltbr-out 4.1411 HRD-in -59.71, -48.0 76.59, -4.26 out-in-in SNCoii in-in ActLoopNT-in 2.8364 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.23, 151.56 APE9-dihe-na 136.82, 177.58 APE8-dihe-in -97.3, 113.73 APE8-rot-in 307.05 APE67-dihe-in -59.8, -18.2 -41.32, -48.97 APE12-dist-in 10.0594 APE11-dist-in 11.5265 APE10-dist-in 6.3643 APE9-dist-in 3.9131 None TPO345,SEP346 TPO345,SEP346 XRAY 3.031 0.227 0.274 B 308.0 275.0 19 30 22 8 [[183, 456]] 1.0 7qg2 TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 7QG2C Q9NWZ3 164 458 460.0 B6I:501 Type1 Inactive DFGin 6.9577 14.1725 BLAminus -123.88, 179.51 55.6, 95.37 -116.47, 22.24 302.05, 94.49 -66.41, -26.71 in-out in 8.9488 Saltbr-out 4.3168 HRD-in -60.39, -48.1 75.35, -2.7 out-in-in SNCoii in-in ActLoopNT-in 2.8488 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.09, 152.33 APE9-dihe-na 135.79, 177.88 APE8-dihe-in -96.73, 114.77 APE8-rot-in 307.98 APE67-dihe-in -59.31, -19.42 -43.08, -47.58 APE12-dist-in 10.1175 APE11-dist-in 11.6603 APE10-dist-in 6.4245 APE9-dist-in 3.9036 None TPO345,SEP346 TPO345,SEP346 XRAY 3.031 0.227 0.274 C 308.0 284.0 11 30 23 7 [[183, 456]] 1.0 7qg2 TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 7QG2D Q9NWZ3 164 458 460.0 B6I:501 Type1 Inactive DFGin 6.8695 14.5085 BLAminus -124.89, 178.48 57.48, 94.84 -118.64, 27.39 301.07, 100.0 -70.03, -20.47 in-out in 8.921 Saltbr-out 4.276 HRD-in -61.48, -47.48 76.38, -5.16 out-in-in SNCoii in-in ActLoopNT-in 2.8424 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.84, 151.37 APE9-dihe-na 137.51, 176.91 APE8-dihe-in -97.58, 114.3 APE8-rot-in 305.98 APE67-dihe-in -59.32, -18.8 -41.34, -49.0 APE12-dist-in 9.8967 APE11-dist-in 11.6128 APE10-dist-in 6.4087 APE9-dist-in 3.9216 None TPO345,SEP346 TPO345,SEP346 XRAY 3.031 0.227 0.274 D 308.0 280.0 15 30 23 7 [[183, 456]] 1.0 7qg2 TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 7QG3B Q9NWZ3 164 458 460.0 B4U:501 Type1 Inactive DFGin 6.8462 14.6838 BLAminus -132.44, 171.27 64.36, 88.43 -111.84, 26.31 313.62, 91.35 -71.36, -21.35 in-out in 8.677 Saltbr-out 5.0214 HRD-in -67.36, -50.82 78.83, -8.31 out-in-in SNCoii in-in ActLoopNT-in 2.7775 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.2, 142.27 APE9-dihe-na 152.04, -166.56 APE8-dihe-in -110.23, 113.93 APE8-rot-in 316.42 APE67-dihe-in -63.34, -18.6 -57.19, -37.15 APE12-dist-in 10.7684 APE11-dist-in 11.7378 APE10-dist-in 6.6852 APE9-dist-in 4.2629 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.11 0.273 0.304 B 308.0 283.0 12 30 24 6 [[183, 456]] 1.0 7qg3 TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 7QG5A Q9NWZ3 165 458 460.0 B7R:501 Type1 Inactive DFGin 6.578 14.4932 BLAminus -124.15, 174.43 61.08, 84.14 -101.81, 21.99 311.05, 99.37 -64.51, -29.58 in-out in 8.8835 Saltbr-out 3.9488 HRD-in -68.99, -49.5 76.63, -2.55 out-in-in SNCoii in-in ActLoopNT-in 2.8887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.94, 161.62 APE9-dihe-na 129.5, -173.09 APE8-dihe-in -108.69, 116.59 APE8-rot-in 312.95 APE67-dihe-in -65.31, -14.05 -47.57, -46.29 APE12-dist-in 9.9238 APE11-dist-in 11.7586 APE10-dist-in 6.4022 APE9-dist-in 3.9224 None TPO345,SEP346 TPO345,SEP346 XRAY 2.3 0.249 0.275 A 308.0 270.0 24 30 24 6 [[183, 456]] 1.0 7qg5 TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 7QG5B Q9NWZ3 164 458 460.0 B7R:501 Type1 Inactive DFGin 7.0578 14.3827 BLAminus -131.21, 172.38 65.67, 86.88 -104.52, 23.37 306.02, 106.65 -68.49, -29.45 in-out in 8.8038 Saltbr-out 3.9184 HRD-in -70.17, -49.03 75.63, -1.79 out-in-in SNCoii in-in ActLoopNT-in 2.8968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.87, 162.12 APE9-dihe-na 129.84, -172.51 APE8-dihe-in -109.04, 117.43 APE8-rot-in 313.01 APE67-dihe-in -64.34, -13.55 -51.38, -43.59 APE12-dist-in 10.0182 APE11-dist-in 11.6188 APE10-dist-in 6.3383 APE9-dist-in 3.9707 None TPO345,SEP346 TPO345,SEP346 XRAY 2.3 0.249 0.275 B 308.0 281.0 14 30 24 6 [[183, 456]] 1.0 7qg5 TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 9R9GA Q9NWZ3 163 458 460.0 Y9T:501 Type1 Inactive DFGin 6.948 14.2471 BLAminus -130.74, 175.0 63.76, 86.61 -108.65, 17.69 308.07, 98.94 -62.62, -29.22 in-out in 8.7339 Saltbr-out 4.8435 HRD-in -68.25, -50.26 77.88, -4.02 out-in-in SNCoii in-in ActLoopNT-in 2.8599 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.63, 160.85 APE9-dihe-na 132.15, -171.04 APE8-dihe-in -115.27, 115.04 APE8-rot-in 308.73 APE67-dihe-in -62.64, -15.32 -49.18, -44.92 APE12-dist-in 9.8967 APE11-dist-in 11.8568 APE10-dist-in 6.4089 APE9-dist-in 3.6889 None TPO345,SEP346 TPO345,SEP346 XRAY 1.88 0.204 0.228 A 308.0 286.0 10 30 25 5 [[183, 456]] 1.0 9r9g TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 9R9GB Q9NWZ3 163 458 460.0 Y9T:501 Type1 Inactive DFGin 6.9319 14.2655 BLAminus -125.04, 172.39 63.91, 85.11 -106.57, 17.26 306.3, 94.34 -62.58, -32.77 in-out in 8.6918 Saltbr-out 4.0108 HRD-in -67.99, -51.01 79.32, -6.48 out-in-in SNCoii in-in ActLoopNT-in 2.8491 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.63, 159.54 APE9-dihe-na 133.41, -171.38 APE8-dihe-in -115.54, 114.65 APE8-rot-in 308.5 APE67-dihe-in -62.16, -14.91 -45.99, -48.35 APE12-dist-in 9.9025 APE11-dist-in 11.9461 APE10-dist-in 6.482 APE9-dist-in 3.7204 None TPO345,SEP346 TPO345,SEP346 XRAY 1.88 0.204 0.228 B 308.0 286.0 10 30 25 5 [[183, 456]] 1.0 9r9g TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 9R9GC Q9NWZ3 164 458 460.0 Y9T:501 Type1 Inactive DFGin 7.0674 14.0996 BLAminus -129.01, 170.18 68.19, 86.48 -108.0, 15.16 307.09, 99.37 -62.89, -29.47 in-out in 8.5991 Saltbr-out 4.7702 HRD-in -67.95, -50.9 79.35, -5.74 out-in-in SNCoii in-in ActLoopNT-in 2.8497 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.34, 160.8 APE9-dihe-na 132.4, -171.76 APE8-dihe-in -114.85, 114.71 APE8-rot-in 307.49 APE67-dihe-in -61.59, -16.4 -48.9, -45.19 APE12-dist-in 9.893 APE11-dist-in 11.8233 APE10-dist-in 6.3745 APE9-dist-in 3.6951 None TPO345,SEP346 TPO345,SEP346 XRAY 1.88 0.204 0.228 C 308.0 286.0 9 30 25 5 [[183, 456]] 1.0 9r9g TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 9R9GD Q9NWZ3 164 458 460.0 Y9T:501 Type1 Inactive DFGin 7.0205 13.9212 BLAminus -128.78, 173.52 64.74, 84.24 -108.04, 17.03 309.57, 97.28 -63.17, -27.35 in-out in 8.6739 Saltbr-out 5.7794 HRD-in -67.79, -51.04 79.66, -6.4 out-in-in SNCoii in-in ActLoopNT-in 2.8362 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.94, 160.1 APE9-dihe-na 133.16, -172.19 APE8-dihe-in -114.51, 114.26 APE8-rot-in 307.76 APE67-dihe-in -62.14, -15.82 -42.97, -50.29 APE12-dist-in 9.8576 APE11-dist-in 11.8526 APE10-dist-in 6.3769 APE9-dist-in 3.6866 None TPO345,SEP346 TPO345,SEP346 XRAY 1.88 0.204 0.228 D 308.0 286.0 9 30 24 6 [[183, 456]] 1.0 9r9g TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 9R9KD Q9NWZ3 164 459 460.0 A1JDQ:501 Type1 Inactive DFGin 7.2627 13.9086 BLAminus -127.82, -173.62 51.62, 79.16 -94.28, 25.38 306.25, 90.36 -67.69, -32.97 in-out in 9.2191 Saltbr-out 3.6855 HRD-in -67.18, -49.93 79.82, -9.59 out-in-in SNCoii in-in ActLoopNT-in 2.8601 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.33, 161.69 APE9-dihe-na 131.99, -171.77 APE8-dihe-in -113.49, 115.43 APE8-rot-in 306.97 APE67-dihe-in -64.18, -12.29 -42.85, -50.18 APE12-dist-in 10.2285 APE11-dist-in 11.6612 APE10-dist-in 6.2577 APE9-dist-in 3.6952 None TPO345,SEP346 TPO345,SEP346 XRAY 1.87 0.216 0.242 D 308.0 287.0 9 30 25 5 [[183, 456]] 1.0 9r9k TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6O94A Q9NWZ3 163 458 460.0 LRS:502 Type1 Inactive DFGin 6.9797 13.9567 BLAminus -123.25, 179.18 58.62, 91.23 -110.31, 12.12 305.58, 96.78 -63.69, -27.63 in-out in 9.1142 Saltbr-out 5.0245 HRD-in -68.39, -52.68 75.29, -1.68 out-in-in SNCoii in-in ActLoopNT-in 2.8366 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.99, 140.47 APE9-dihe-na 148.46, -177.74 APE8-dihe-in -101.2, 107.55 APE8-rot-in 306.34 APE67-dihe-in -55.1, -20.47 -45.77, -47.94 APE12-dist-in 10.0718 APE11-dist-in 12.0661 APE10-dist-in 7.3254 APE9-dist-in 5.2183 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.98 0.184 0.215 A 320.0 292.0 4 30 26 4 [[183, 456]] 1.0 6o94 TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6O94B Q9NWZ3 162 458 460.0 LRS:502 Type1 Inactive DFGin 6.899 14.0279 BLAminus -122.58, 179.95 63.12, 86.64 -108.65, 9.89 303.71, 93.33 -58.6, -27.16 in-out in 8.998 Saltbr-out 4.9134 HRD-in -65.66, -51.1 74.78, 1.16 out-in-in SNCoii in-in ActLoopNT-in 2.8194 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.21, 144.66 APE9-dihe-na 140.06, 177.25 APE8-dihe-in -95.53, 110.29 APE8-rot-in 309.4 APE67-dihe-in -63.88, -19.8 -59.96, -25.96 APE12-dist-in 10.2683 APE11-dist-in 12.0988 APE10-dist-in 7.0791 APE9-dist-in 4.8461 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.98 0.184 0.215 B 320.0 293.0 4 30 26 4 [[183, 456]] 1.0 6o94 TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6O94C Q9NWZ3 163 458 460.0 LRS:501 Type1 Inactive DFGin 6.5899 14.128 BLAminus -121.22, 176.46 62.3, 93.01 -113.1, 16.55 308.78, 90.13 -63.81, -32.68 in-out in 8.6856 Saltbr-out 4.062 HRD-in -68.33, -51.83 77.7, -5.17 out-in-in SNCoii in-in ActLoopNT-in 2.7983 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.28, 149.13 APE9-dihe-na 136.69, -178.03 APE8-dihe-in -101.68, 113.37 APE8-rot-in 311.59 APE67-dihe-in -65.13, -21.18 -43.64, -46.59 APE12-dist-in 9.9441 APE11-dist-in 12.0198 APE10-dist-in 6.6751 APE9-dist-in 4.3492 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.98 0.184 0.215 C 320.0 286.0 10 30 26 4 [[183, 456]] 1.0 6o94 TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6O94D Q9NWZ3 163 458 460.0 LRS:501 Type1 Inactive DFGin 7.0029 14.0207 BLAminus -126.53, 176.59 61.66, 94.12 -114.42, 13.3 307.72, 104.0 -58.57, -29.78 in-out in 8.9166 Saltbr-out 4.8918 HRD-in -70.14, -50.46 72.65, -1.5 out-in-in SNCoii in-in ActLoopNT-in 2.7844 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.81, 156.44 APE9-dihe-na 122.83, -176.0 APE8-dihe-in -107.14, 110.01 APE8-rot-in 318.74 APE67-dihe-in -57.74, -23.07 -42.07, -49.71 APE12-dist-in 10.2874 APE11-dist-in 12.0683 APE10-dist-in 6.673 APE9-dist-in 4.3687 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.98 0.184 0.215 D 320.0 285.0 11 30 25 5 [[183, 456]] 1.0 6o94 TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6O95A Q9NWZ3 162 459 460.0 LSV:502 Type1 Inactive DFGin 6.5143 14.1644 BLAminus -124.69, 178.36 63.9, 85.02 -104.54, 7.03 304.14, 94.6 -57.19, -35.8 in-out in 8.8719 Saltbr-out 4.6326 HRD-in -66.91, -51.29 74.49, -0.76 out-in-in SNCoii in-in ActLoopNT-in 2.8041 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.02, 155.29 APE9-dihe-na 132.54, -175.83 APE8-dihe-in -104.27, 113.04 APE8-rot-in 302.9 APE67-dihe-in -57.84, -19.71 -40.16, -52.66 APE12-dist-in 10.0524 APE11-dist-in 12.0481 APE10-dist-in 6.8824 APE9-dist-in 4.3628 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.77 0.19 0.217 A 320.0 291.0 7 30 25 5 [[183, 456]] 1.0 6o95 TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6O95B Q9NWZ3 163 458 460.0 LSV:501 Type1 Inactive DFGin 7.047 13.9336 BLAminus -128.69, 178.37 64.78, 86.4 -106.95, 10.27 304.55, 103.52 -56.04, -36.05 in-out in 8.6869 Saltbr-out 5.348 HRD-in -68.16, -49.56 73.95, -1.69 out-in-in SNCoii in-in ActLoopNT-in 2.8208 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.52, 156.12 APE9-dihe-na 128.25, -179.73 APE8-dihe-in -105.09, 111.99 APE8-rot-in 310.32 APE67-dihe-in -60.91, -16.95 -44.72, -45.17 APE12-dist-in 10.1353 APE11-dist-in 12.0602 APE10-dist-in 6.4328 APE9-dist-in 4.0004 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.77 0.19 0.217 B 320.0 279.0 17 30 25 5 [[183, 456]] 1.0 6o95 TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6O95C Q9NWZ3 165 458 460.0 LSV:501 Type1 Inactive DFGin 6.9177 13.9296 BLAminus -128.33, 177.09 66.35, 90.72 -113.17, 15.76 309.56, 95.89 -60.57, -32.1 in-out in 8.9463 Saltbr-out 4.8251 HRD-in -67.67, -54.03 77.11, 0.43 out-in-in SNCoii in-in ActLoopNT-in 2.8077 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.77, 148.25 APE9-dihe-na 141.05, -171.27 APE8-dihe-in -106.42, 112.41 APE8-rot-in 303.07 APE67-dihe-in -59.27, -17.89 -44.67, -47.52 APE12-dist-in 10.0305 APE11-dist-in 12.0003 APE10-dist-in 7.1669 APE9-dist-in 4.8503 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.77 0.19 0.217 C 320.0 286.0 8 30 25 5 [[183, 456]] 1.0 6o95 TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6O95D Q9NWZ3 161 458 460.0 LSV:503 Type1 Inactive DFGin 6.7141 13.781 BLAminus -126.14, -178.81 60.46, 90.73 -111.09, 9.64 304.76, 99.65 -59.01, -30.48 in-out in 8.9078 Saltbr-out 4.9695 HRD-in -67.54, -51.97 72.39, 2.38 out-in-in SNCoii in-in ActLoopNT-in 2.8137 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.99, 146.99 APE9-dihe-na 137.73, 178.81 APE8-dihe-in -100.23, 111.63 APE8-rot-in 301.88 APE67-dihe-in -63.03, -17.06 -59.78, -27.35 APE12-dist-in 10.1677 APE11-dist-in 11.9475 APE10-dist-in 6.7267 APE9-dist-in 4.7161 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.77 0.19 0.217 D 320.0 292.0 6 30 24 6 [[183, 456]] 1.0 6o95 TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6O9DA Q9NWZ3 162 458 460.0 LTY:501 Type1 Inactive DFGin 6.7066 14.4556 BLAminus -127.76, -176.84 57.79, 87.99 -106.68, 3.04 297.04, 103.76 -53.04, -31.02 in-out in 8.3352 Saltbr-out 3.6179 HRD-in -61.91, -55.52 80.82, -6.22 out-in-in SNCoii in-in ActLoopNT-in 2.7956 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.17, 155.38 APE9-dihe-na 127.36, -176.8 APE8-dihe-in -102.61, 119.68 APE8-rot-in 323.19 APE67-dihe-in -59.01, -22.88 -47.44, -49.99 APE12-dist-in 9.9006 APE11-dist-in 11.5992 APE10-dist-in 6.2466 APE9-dist-in 3.9113 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.51 0.197 0.239 A 320.0 286.0 11 30 26 4 [[183, 456]] 1.0 6o9d TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6O9DB Q9NWZ3 163 458 460.0 LTY:501 Type1 Inactive DFGin 7.0573 13.9514 BLAminus -143.03, -179.16 58.94, 82.95 -104.14, 17.08 307.96, 103.48 -62.26, -32.09 in-out in 8.6875 Saltbr-out 4.2071 HRD-in -62.85, -48.11 75.04, -10.08 out-in-in SNCoii in-in ActLoopNT-in 2.9311 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.13, 158.27 APE9-dihe-na 134.69, -173.08 APE8-dihe-in -118.39, 112.91 APE8-rot-in 312.26 APE67-dihe-in -64.54, -21.64 -47.5, -39.01 APE12-dist-in 10.1336 APE11-dist-in 11.7619 APE10-dist-in 6.3028 APE9-dist-in 4.0783 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.51 0.197 0.239 B 320.0 284.0 12 30 25 5 [[183, 456]] 1.0 6o9d TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6O9DD Q9NWZ3 164 458 460.0 LTY:501 Type1 Inactive DFGin 6.8994 14.3177 BLAminus -134.66, 178.58 59.54, 82.94 -104.76, 14.4 302.36, 96.51 -59.1, -33.56 in-out in 8.7304 Saltbr-out 4.0778 HRD-in -68.8, -51.26 82.92, -3.16 out-in-in SNCoii in-in ActLoopNT-in 2.7865 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.38, 156.72 APE9-dihe-na 130.79, 174.85 APE8-dihe-in -97.61, 110.6 APE8-rot-in 318.14 APE67-dihe-in -67.31, -17.64 -49.18, -44.21 APE12-dist-in 10.2848 APE11-dist-in 11.7694 APE10-dist-in 6.4018 APE9-dist-in 4.2439 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.51 0.197 0.239 D 320.0 284.0 11 30 27 3 [[183, 456]] 1.0 6o9d TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6UYAA Q9NWZ3 163 458 460.0 QL7:501 Type1 Inactive DFGin 6.9118 14.0613 BLAminus -130.83, 174.58 66.33, 88.53 -109.61, 11.93 305.77, 104.97 -60.29, -30.37 in-out in 8.9208 Saltbr-out 5.3891 HRD-in -66.32, -52.06 75.53, -1.71 out-in-in SNCoii in-in ActLoopNT-in 2.7571 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.77, 155.18 APE9-dihe-na 131.38, -176.71 APE8-dihe-in -108.73, 111.35 APE8-rot-in 311.67 APE67-dihe-in -54.65, -22.72 -39.48, -51.06 APE12-dist-in 10.4706 APE11-dist-in 12.0745 APE10-dist-in 6.6655 APE9-dist-in 4.1482 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.74 0.182 0.207 A 320.0 288.0 8 30 25 5 [[183, 456]] 1.0 6uya TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6UYAB Q9NWZ3 165 458 460.0 QL7:502 Type1 Inactive DFGin 6.893 13.9843 BLAminus -128.71, 175.35 66.38, 92.59 -112.91, 7.52 303.04, 106.99 -58.83, -29.06 in-out in 9.0 Saltbr-out 5.0833 HRD-in -69.36, -50.91 73.85, 5.13 out-in-in SNCoii in-in ActLoopNT-in 2.8239 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.22, 142.0 APE9-dihe-na 152.09, 178.07 APE8-dihe-in -98.25, 109.05 APE8-rot-in 300.26 APE67-dihe-in -55.26, -18.41 -44.33, -48.88 APE12-dist-in 10.1551 APE11-dist-in 11.9953 APE10-dist-in 7.2576 APE9-dist-in 5.0479 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.74 0.182 0.207 B 320.0 290.0 4 30 26 4 [[183, 456]] 1.0 6uya TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6UYAD Q9NWZ3 162 458 460.0 QL7:501 Type1 Inactive DFGin 6.8191 13.7579 BLAminus -128.37, 176.07 66.47, 90.2 -111.03, 7.65 306.44, 101.65 -54.58, -29.97 in-out in 8.9183 Saltbr-out 4.6606 HRD-in -66.75, -50.48 73.09, -0.55 out-in-in SNCoii in-in ActLoopNT-in 2.8044 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.42, 146.21 APE9-dihe-na 142.04, -178.31 APE8-dihe-in -100.42, 112.16 APE8-rot-in 302.67 APE67-dihe-in -61.72, -16.37 -57.08, -31.92 APE12-dist-in 10.0883 APE11-dist-in 11.9674 APE10-dist-in 6.9354 APE9-dist-in 4.7438 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.74 0.182 0.207 D 320.0 291.0 6 30 24 6 [[183, 456]] 1.0 6uya TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6F3IA Q9NWZ3 165 458 460.0 CKN:501 Type1 Inactive DFGin 7.0541 14.3219 BLAminus -123.52, -179.8 60.09, 89.16 -112.89, 21.06 305.23, 95.52 -66.66, -30.45 in-out in 8.6589 Saltbr-out 8.1067 HRD-in -71.48, -51.41 77.44, -5.11 out-in-in SNCoii in-in ActLoopNT-in 2.7963 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.09, 147.59 APE9-dihe-na 131.67, -176.65 APE8-dihe-in -98.22, 114.27 APE8-rot-in 316.92 APE67-dihe-in -58.79, -21.5 -51.79, -39.53 APE12-dist-in 10.2249 APE11-dist-in 12.0072 APE10-dist-in 6.5371 APE9-dist-in 4.3271 None TPO345,SEP346 TPO345,SEP346 XRAY 2.14 0.237 0.27 A 322.0 260.0 34 30 23 7 [[183, 456]] 1.0 6f3i TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6F3IB Q9NWZ3 164 458 460.0 CKN:502 Type1 Inactive DFGin 7.0734 14.7278 BLAminus -124.14, 177.7 62.74, 84.47 -108.24, 21.83 305.38, 94.82 -65.48, -30.96 in-out in 9.2285 Saltbr-out 6.0168 HRD-in -71.3, -51.64 77.0, -4.42 out-in-in SNCoii in-in ActLoopNT-in 2.8027 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.51, 147.67 APE9-dihe-na 131.82, -176.31 APE8-dihe-in -97.78, 113.9 APE8-rot-in 318.2 APE67-dihe-in -58.63, -21.1 -51.98, -39.95 APE12-dist-in 10.2485 APE11-dist-in 11.8868 APE10-dist-in 6.4604 APE9-dist-in 4.3589 None TPO345,SEP346 TPO345,SEP346 XRAY 2.14 0.237 0.27 B 322.0 281.0 14 30 23 7 [[183, 456]] 1.0 6f3i TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6RFIA Q9NWZ3 165 458 460.0 K1H:502 Type1 Inactive DFGin 6.9898 14.3021 BLAminus -129.16, 176.7 63.09, 88.81 -109.76, 14.57 309.19, 95.71 -60.71, -34.41 in-out in 8.9539 Saltbr-out 4.6447 HRD-in -64.1, -51.33 77.3, -1.49 out-in-in SNCoii in-in ActLoopNT-in 2.9423 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.51, 158.58 APE9-dihe-na 128.54, -171.69 APE8-dihe-in -107.47, 116.44 APE8-rot-in 316.16 APE67-dihe-in -66.19, -16.15 -43.18, -47.25 APE12-dist-in 10.0116 APE11-dist-in 11.8198 APE10-dist-in 6.3514 APE9-dist-in 3.7063 None TPO345,SEP346 TPO345,SEP346 XRAY 2.31 0.211 0.236 A 322.0 275.0 19 30 25 5 [[183, 456]] 1.0 6rfi TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6RFIB Q9NWZ3 164 458 460.0 K1H:502 Type1 Inactive DFGin 7.0642 14.0503 BLAminus -129.63, 173.33 61.36, 88.99 -110.28, 17.12 308.46, 99.08 -63.95, -28.47 in-out in 8.8564 Saltbr-out 4.3159 HRD-in -66.26, -50.83 78.99, -1.16 out-in-in SNCoii in-in ActLoopNT-in 2.7779 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.66, 154.17 APE9-dihe-na 132.35, -169.11 APE8-dihe-in -111.83, 120.53 APE8-rot-in 311.0 APE67-dihe-in -70.4, -14.87 -59.89, -31.07 APE12-dist-in 10.04 APE11-dist-in 11.875 APE10-dist-in 6.3304 APE9-dist-in 3.7215 None TPO345,SEP346 TPO345,SEP346 XRAY 2.31 0.211 0.236 B 322.0 280.0 15 30 22 8 [[183, 456]] 1.0 6rfi TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6RFJA Q9NWZ3 165 458 460.0 K1E:501 Type1 Inactive DFGin 6.7312 14.2145 BLAminus -138.26, 177.45 62.01, 88.8 -111.36, 12.54 307.73, 96.46 -63.8, -18.03 in-out in 8.9085 Saltbr-out 4.5689 HRD-in -70.21, -47.87 75.12, -3.47 out-in-in SNCoii in-in ActLoopNT-in 2.7494 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.34, 157.08 APE9-dihe-na 130.62, -174.05 APE8-dihe-in -112.58, 112.94 APE8-rot-in 303.06 APE67-dihe-in -64.16, -16.63 -45.12, -46.37 APE12-dist-in 9.991 APE11-dist-in 11.846 APE10-dist-in 6.2324 APE9-dist-in 3.6713 None TPO345,SEP346 TPO345,SEP346 XRAY 2.61 0.245 0.254 A 322.0 268.0 26 30 23 7 [[183, 456]] 1.0 6rfj TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6RFJB Q9NWZ3 164 458 460.0 K1E:502 Type1 Inactive DFGin 6.98 14.2477 BLAminus -131.73, 178.64 60.17, 79.36 -102.97, 22.96 313.3, 93.8 -64.31, -22.35 in-out in 9.0016 Saltbr-out 4.973 HRD-in -70.9, -51.42 81.49, -4.07 out-in-in SNCoii in-in ActLoopNT-in 2.7843 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.43, 154.68 APE9-dihe-na 135.37, -174.43 APE8-dihe-in -109.42, 116.51 APE8-rot-in 308.77 APE67-dihe-in -61.15, -17.08 -52.21, -44.98 APE12-dist-in 10.1202 APE11-dist-in 11.8217 APE10-dist-in 6.2407 APE9-dist-in 3.8303 None TPO345,SEP346 TPO345,SEP346 XRAY 2.61 0.245 0.254 B 322.0 279.0 16 30 22 8 [[183, 456]] 1.0 6rfj TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 7QG1A Q9NWZ3 165 458 460.0 B8I:501 Type1 Inactive DFGin 7.02 14.3894 BLAminus -118.81, -178.64 55.1, 76.86 -97.97, 21.19 305.6, 72.54 -63.87, -32.47 in-out in 8.4699 Saltbr-out 5.3619 HRD-in -68.86, -48.74 75.05, -2.97 out-in-in SNCoii in-in ActLoopNT-in 2.8001 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.97, 148.67 APE9-dihe-na 139.86, -177.08 APE8-dihe-in -100.51, 118.37 APE8-rot-in 305.34 APE67-dihe-in -60.75, -17.99 -59.84, -38.95 APE12-dist-in 10.0839 APE11-dist-in 11.8182 APE10-dist-in 6.3351 APE9-dist-in 4.0571 None TPO345,SEP346 TPO345,SEP346 XRAY 2.07 0.249 0.285 A 322.0 266.0 28 30 23 7 [[183, 456]] 1.0 7qg1 TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 7QG1B Q9NWZ3 164 458 460.0 B8I:501 Type1 Inactive DFGin 7.2031 14.7406 BLAminus -127.97, 179.77 66.68, 77.1 -104.37, 20.94 303.7, 91.21 -70.61, -31.96 in-out in 8.7539 Saltbr-out 4.3527 HRD-in -69.99, -48.76 75.97, -2.57 out-in-in SNCoii in-in ActLoopNT-in 2.773 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.49, 147.07 APE9-dihe-na 141.42, -176.13 APE8-dihe-in -101.1, 117.88 APE8-rot-in 306.31 APE67-dihe-in -60.31, -17.27 -61.18, -38.28 APE12-dist-in 10.0926 APE11-dist-in 11.7254 APE10-dist-in 6.2972 APE9-dist-in 4.1112 None TPO345,SEP346 TPO345,SEP346 XRAY 2.07 0.249 0.285 B 322.0 282.0 13 30 23 7 [[183, 456]] 1.0 7qg1 TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5UIQA Q9NWZ3 164 459 460.0 8BV:501 Type1 Inactive DFGin 6.9307 14.3095 BLAminus -127.76, 177.14 59.33, 95.8 -119.34, 15.89 308.77, 95.83 -65.11, -29.47 in-out in 8.6504 Saltbr-out 4.3022 HRD-in -67.28, -50.5 79.56, -0.59 out-in-in SNCoii in-in ActLoopNT-in 2.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.14, 152.7 APE9-dihe-na 138.15, -166.94 APE8-dihe-in -116.13, 111.27 APE8-rot-in 312.43 APE67-dihe-in -63.93, -18.01 -42.44, -46.16 APE12-dist-in 9.8691 APE11-dist-in 11.872 APE10-dist-in 6.4418 APE9-dist-in 3.9304 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.64 0.199 0.226 A 323.0 271.0 25 30 26 4 [[183, 456]] 1.0 5uiq TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5UIQB Q9NWZ3 164 458 460.0 8BV:501 Type1 Inactive DFGin 6.8044 14.3759 BLAminus -130.56, -176.5 54.94, 94.68 -118.91, 16.72 307.57, 95.93 -64.01, -29.62 in-out in 8.8285 Saltbr-out 4.3856 HRD-in -70.9, -49.5 78.92, -1.32 out-in-in SNCoii in-in ActLoopNT-in 2.8073 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.36, 153.22 APE9-dihe-na 140.63, -165.78 APE8-dihe-in -116.87, 110.95 APE8-rot-in 311.97 APE67-dihe-in -63.22, -18.39 -42.29, -46.59 APE12-dist-in 9.9707 APE11-dist-in 11.8372 APE10-dist-in 6.4033 APE9-dist-in 3.9043 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.64 0.199 0.226 B 323.0 275.0 20 30 25 5 [[183, 456]] 1.0 5uiq TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5UIQC Q9NWZ3 164 458 460.0 8BV:501 Type1 Inactive DFGin 6.9897 14.0885 BLAminus -129.3, 173.99 64.73, 91.59 -115.5, 16.73 307.85, 97.93 -64.38, -30.3 in-out in 8.7851 Saltbr-out 4.4015 HRD-in -65.88, -50.65 76.92, 0.42 out-in-in SNCoii in-in ActLoopNT-in 2.7926 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.19, 152.87 APE9-dihe-na 139.13, -167.26 APE8-dihe-in -115.65, 111.65 APE8-rot-in 310.37 APE67-dihe-in -63.01, -19.88 -42.68, -46.48 APE12-dist-in 9.6424 APE11-dist-in 11.8309 APE10-dist-in 6.3933 APE9-dist-in 3.8996 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.64 0.199 0.226 C 323.0 283.0 12 30 26 4 [[183, 456]] 1.0 5uiq TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5UIQD Q9NWZ3 164 458 460.0 8BV:501 Type1 Inactive DFGin 6.9589 14.2657 BLAminus -119.1, 174.77 64.33, 95.9 -120.23, 16.26 309.43, 94.98 -65.41, -29.0 in-out in 8.6314 Saltbr-out 4.2615 HRD-in -57.37, -47.98 74.72, -2.81 out-in-in SNCoii in-in ActLoopNT-in 2.9316 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.96, 150.91 APE9-dihe-na 138.88, -168.68 APE8-dihe-in -114.25, 111.41 APE8-rot-in 310.92 APE67-dihe-in -61.78, -19.41 -45.33, -46.22 APE12-dist-in 9.6136 APE11-dist-in 11.7923 APE10-dist-in 6.3731 APE9-dist-in 3.99 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.64 0.199 0.226 D 323.0 274.0 21 30 24 6 [[183, 456]] 1.0 5uiq TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5UIRA Q9NWZ3 165 458 460.0 8BY:800 Type1 Inactive DFGin 6.9354 14.1138 BLAminus -136.3, 170.5 69.87, 91.85 -112.04, 22.11 309.32, 96.71 -72.39, -36.2 in-out in 8.9664 Saltbr-out 3.7468 HRD-in -63.83, -51.01 78.63, 2.17 out-in-in SNCoii in-in ActLoopNT-in 2.7969 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.87, 150.35 APE9-dihe-na 136.71, -173.51 APE8-dihe-in -100.71, 112.33 APE8-rot-in 315.74 APE67-dihe-in -65.12, -20.89 -48.07, -45.69 APE12-dist-in 9.847 APE11-dist-in 11.5689 APE10-dist-in 6.4183 APE9-dist-in 4.3194 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.64 0.222 0.277 A 323.0 272.0 22 30 22 8 [[183, 456]] 1.0 5uir TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5UIRB Q9NWZ3 164 458 460.0 8BY:801 Type1 Inactive DFGin 6.9002 14.2024 BLAminus -136.36, 170.65 70.05, 91.83 -112.72, 22.02 309.43, 96.93 -72.89, -36.25 in-out in 8.8243 Saltbr-out 3.616 HRD-in -62.53, -51.23 78.89, 1.88 out-in-in SNCoii in-in ActLoopNT-in 2.7897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.66, 150.06 APE9-dihe-na 137.27, -173.33 APE8-dihe-in -99.83, 112.61 APE8-rot-in 313.76 APE67-dihe-in -66.01, -19.75 -48.02, -45.39 APE12-dist-in 9.8686 APE11-dist-in 11.6908 APE10-dist-in 6.4823 APE9-dist-in 4.2738 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.64 0.222 0.277 B 323.0 276.0 19 30 25 5 [[183, 456]] 1.0 5uir TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5UISA Q9NWZ3 165 458 460.0 8C1:800 Type1 Inactive DFGin 7.1118 14.0398 BLAminus -129.58, 176.58 61.82, 86.42 -113.89, 16.49 308.82, 94.47 -62.9, -34.09 in-out in 8.541 Saltbr-out 5.5548 HRD-in -63.14, -50.87 76.52, -0.1 out-in-in SNCoii in-in ActLoopNT-in 2.7767 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.1, 153.54 APE9-dihe-na 136.54, -173.47 APE8-dihe-in -104.82, 108.83 APE8-rot-in 309.6 APE67-dihe-in -61.86, -20.01 -38.21, -50.94 APE12-dist-in 10.0387 APE11-dist-in 11.8275 APE10-dist-in 6.4632 APE9-dist-in 3.9028 None TPO342,TPO345 TPO342,TPO345 XRAY 2.5 0.235 0.25 A 323.0 270.0 24 30 22 8 [[183, 456]] 1.0 5uis TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5UISB Q9NWZ3 165 458 460.0 8C1:801 Type1 Inactive DFGin 7.1692 13.9676 BLAminus -129.92, 177.17 60.99, 86.93 -113.16, 17.11 308.88, 93.79 -61.36, -35.46 in-out in 8.7441 Saltbr-out 6.5207 HRD-in -63.03, -51.01 76.25, -0.93 out-in-in SNCoii in-in ActLoopNT-in 2.7744 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.05, 154.43 APE9-dihe-na 135.24, -173.1 APE8-dihe-in -105.0, 108.25 APE8-rot-in 310.98 APE67-dihe-in -62.29, -20.41 -37.93, -50.24 APE12-dist-in 10.0863 APE11-dist-in 11.8055 APE10-dist-in 6.4182 APE9-dist-in 3.8972 None TPO342,TPO345 TPO342,TPO345 XRAY 2.5 0.235 0.25 B 323.0 275.0 19 30 23 7 [[183, 456]] 1.0 5uis TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5UISC Q9NWZ3 162 458 460.0 8C1:501 Type1 Inactive DFGin 7.0074 14.3874 BLAminus -130.49, 177.24 60.84, 87.43 -113.94, 16.73 308.87, 94.61 -62.1, -34.09 in-out in 8.8684 Saltbr-out 5.5617 HRD-in -63.44, -49.93 76.07, -0.4 out-in-in SNCoii in-in ActLoopNT-in 2.7889 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.1, 154.4 APE9-dihe-na 135.33, -172.81 APE8-dihe-in -104.91, 108.2 APE8-rot-in 311.65 APE67-dihe-in -62.59, -19.93 -37.82, -50.44 APE12-dist-in 10.0518 APE11-dist-in 11.9322 APE10-dist-in 6.5257 APE9-dist-in 3.8867 None TPO342,TPO345 TPO342,TPO345 XRAY 2.5 0.235 0.25 C 323.0 271.0 26 30 22 8 [[183, 456]] 1.0 5uis TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5UISD Q9NWZ3 165 458 460.0 8C1:501 Type1 Inactive DFGin 6.9195 14.3084 BLAminus -130.03, 177.09 61.04, 87.02 -113.16, 16.71 309.14, 94.51 -62.12, -34.57 in-out in 8.8176 Saltbr-out 6.5419 HRD-in -64.13, -50.74 76.91, 0.02 out-in-in SNCoii in-in ActLoopNT-in 2.7878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.65, 153.91 APE9-dihe-na 135.71, -173.08 APE8-dihe-in -105.05, 108.68 APE8-rot-in 311.81 APE67-dihe-in -63.27, -19.62 -38.27, -49.96 APE12-dist-in 10.0324 APE11-dist-in 11.8269 APE10-dist-in 6.4561 APE9-dist-in 3.9118 None TPO342,TPO345 TPO342,TPO345 XRAY 2.5 0.235 0.25 D 323.0 251.0 43 30 22 8 [[183, 456]] 1.0 5uis TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5UITA Q9NWZ3 162 458 460.0 8CD:501 Type1 Inactive DFGin 6.7656 14.1309 BLAminus -128.38, 174.25 65.21, 85.43 -108.44, 15.88 303.94, 92.71 -57.19, -35.46 in-out in 8.8471 Saltbr-out 4.6146 HRD-in -70.51, -45.47 75.95, -8.98 out-in-in SNCoii in-in ActLoopNT-in 2.7454 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.37, 160.28 APE9-dihe-na 137.06, -174.06 APE8-dihe-in -107.79, 113.28 APE8-rot-in 302.72 APE67-dihe-in -66.32, -7.6 -45.31, -45.85 APE12-dist-in 9.8884 APE11-dist-in 11.6608 APE10-dist-in 6.1877 APE9-dist-in 3.6535 None TPO345,SEP346 TPO345,SEP346 XRAY 1.84 0.183 0.218 A 323.0 286.0 11 30 25 5 [[183, 456]] 1.0 5uit TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5UITB Q9NWZ3 164 458 460.0 8CD:501 Type1 Inactive DFGin 6.9737 13.9393 BLAminus -129.91, 176.45 70.0, 83.22 -107.54, 18.86 303.43, 95.85 -65.97, -22.62 in-out in 8.6891 Saltbr-out 5.2639 HRD-in -66.11, -49.66 75.87, -4.01 out-in-in SNCoii in-in ActLoopNT-in 2.615 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.66, 166.35 APE9-dihe-na 133.13, -174.76 APE8-dihe-in -106.63, 115.01 APE8-rot-in 307.0 APE67-dihe-in -65.75, -11.97 -51.76, -39.05 APE12-dist-in 9.7232 APE11-dist-in 11.7832 APE10-dist-in 6.5251 APE9-dist-in 3.674 None TPO345,SEP346 TPO345,SEP346 XRAY 1.84 0.183 0.218 B 323.0 285.0 10 30 25 5 [[183, 456]] 1.0 5uit TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5UIUA Q9NWZ3 165 458 460.0 8CG:4000 Type1 Inactive DFGin 7.0714 14.1912 BLAminus -128.0, 178.75 57.4, 86.68 -103.61, 15.12 305.49, 98.8 -59.8, -27.73 in-out in 9.029 Saltbr-out 3.9038 HRD-in -69.77, -50.91 79.77, -5.91 out-in-in SNCoii in-in ActLoopNT-in 2.7343 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.31, 159.24 APE9-dihe-na 132.22, -173.23 APE8-dihe-in -109.61, 111.77 APE8-rot-in 308.77 APE67-dihe-in -62.44, -17.23 -49.55, -40.12 APE12-dist-in 10.0557 APE11-dist-in 11.9469 APE10-dist-in 6.4345 APE9-dist-in 3.8865 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.02 0.186 0.204 A 323.0 289.0 5 30 25 5 [[183, 456]] 1.0 5uiu TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5UIUB Q9NWZ3 164 458 460.0 8CG:4000 Type1 Inactive DFGin 7.0024 14.0448 BLAminus -130.9, 173.2 66.57, 85.65 -106.49, 15.18 305.82, 98.74 -60.25, -27.45 in-out in 9.0772 Saltbr-out 4.1991 HRD-in -69.82, -51.52 78.72, -3.57 out-in-in SNCoii in-in ActLoopNT-in 2.7287 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.42, 157.5 APE9-dihe-na 132.2, -173.12 APE8-dihe-in -109.05, 111.57 APE8-rot-in 309.25 APE67-dihe-in -61.49, -18.85 -44.37, -45.98 APE12-dist-in 10.1021 APE11-dist-in 11.9995 APE10-dist-in 6.4787 APE9-dist-in 3.9707 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.02 0.186 0.204 B 323.0 290.0 5 30 25 5 [[183, 456]] 1.0 5uiu TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8W3XA Q9NWZ3 162 460 460.0 A1AFH:501 Type1 Inactive DFGin 6.7631 14.0864 BLAminus -129.8, 175.53 62.33, 85.97 -101.36, 14.33 304.54, 100.12 -62.52, -27.4 in-out in 8.8657 Saltbr-out 4.4893 HRD-in -68.21, -49.93 76.52, -2.3 out-in-in SNCoii in-in ActLoopNT-in 2.8548 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.65, 160.15 APE9-dihe-na 133.09, -174.82 APE8-dihe-in -108.97, 112.7 APE8-rot-in 305.97 APE67-dihe-in -63.54, -15.82 -41.12, -50.5 APE12-dist-in 9.9893 APE11-dist-in 11.7283 APE10-dist-in 6.3538 APE9-dist-in 3.8624 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.765 0.191 0.212 A 323.0 289.0 10 30 25 5 [[183, 456]] 1.0 8w3x TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8W3XB Q9NWZ3 162 459 460.0 A1AFH:501 Type1 Inactive DFGin 6.7194 14.083 BLAminus -131.86, 175.94 61.72, 86.86 -102.91, 14.0 304.56, 100.34 -62.32, -27.57 in-out in 8.8165 Saltbr-out 4.434 HRD-in -69.04, -50.02 77.17, -2.0 out-in-in SNCoii in-in ActLoopNT-in 2.8469 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.36, 162.06 APE9-dihe-na 132.25, -173.81 APE8-dihe-in -109.37, 111.4 APE8-rot-in 305.14 APE67-dihe-in -62.67, -15.91 -40.92, -50.44 APE12-dist-in 10.0144 APE11-dist-in 11.7727 APE10-dist-in 6.3777 APE9-dist-in 3.7844 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.765 0.191 0.212 B 323.0 289.0 9 30 25 5 [[183, 456]] 1.0 8w3x TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8W3XC Q9NWZ3 164 459 460.0 A1AFH:501 Type1 Inactive DFGin 6.9712 14.0541 BLAminus -133.25, 171.05 66.34, 84.83 -102.34, 14.62 305.45, 100.45 -62.92, -27.96 in-out in 8.9904 Saltbr-out 4.5117 HRD-in -68.29, -50.47 77.57, -3.07 out-in-in SNCoii in-in ActLoopNT-in 2.837 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.14, 159.95 APE9-dihe-na 132.75, -174.83 APE8-dihe-in -108.93, 112.47 APE8-rot-in 307.06 APE67-dihe-in -62.79, -16.23 -41.81, -49.04 APE12-dist-in 10.0996 APE11-dist-in 11.9677 APE10-dist-in 6.5219 APE9-dist-in 3.8336 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.765 0.191 0.212 C 323.0 288.0 8 30 26 4 [[183, 456]] 1.0 8w3x TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8W3XD Q9NWZ3 164 459 460.0 A1AFH:501 Type1 Inactive DFGin 6.9677 13.9927 BLAminus -130.92, 172.36 64.58, 86.68 -103.48, 14.54 305.1, 100.07 -62.66, -26.7 in-out in 8.8521 Saltbr-out 4.3981 HRD-in -69.41, -50.81 77.69, -1.46 out-in-in SNCoii in-in ActLoopNT-in 2.843 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.51, 160.43 APE9-dihe-na 133.04, -172.94 APE8-dihe-in -110.16, 111.74 APE8-rot-in 305.95 APE67-dihe-in -63.06, -15.81 -41.04, -49.97 APE12-dist-in 9.9983 APE11-dist-in 11.7911 APE10-dist-in 6.4283 APE9-dist-in 3.8999 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.765 0.191 0.212 D 323.0 287.0 9 30 26 4 [[183, 456]] 1.0 8w3x TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8V1OA Q9NWZ3 163 459 460.0 Y9T:501 Type1 Inactive DFGin 6.8549 14.2482 BLAminus -140.64, 168.57 69.95, 86.27 -108.05, 19.4 305.86, 96.59 -62.38, -30.29 in-out in 8.9505 Saltbr-out 4.347 HRD-in -60.57, -58.78 78.86, 6.37 out-in-in SNCoii in-in ActLoopNT-in 2.7463 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.84, 152.18 APE9-dihe-na 140.36, 176.78 APE8-dihe-in -102.6, 111.09 APE8-rot-in 311.94 APE67-dihe-in -57.16, -25.0 -36.59, -53.2 APE12-dist-in 9.9458 APE11-dist-in 11.7778 APE10-dist-in 6.4265 APE9-dist-in 3.6969 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.92 0.219 0.266 A 327.0 290.0 7 30 27 3 [[183, 456]] 1.0 8v1o TKL_IRAK4_HUMAN TKL 5.5e-84 287.8 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8V1OB Q9NWZ3 164 459 460.0 Y9T:501 Type1 Inactive DFGin 6.8614 14.2977 BLAminus -140.52, 168.93 69.44, 87.06 -107.94, 19.45 305.05, 96.72 -62.6, -30.13 in-out in 8.769 Saltbr-out 3.6904 HRD-in -60.51, -59.01 78.22, 6.98 out-in-in SNCoii in-in ActLoopNT-in 2.7706 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.06, 153.17 APE9-dihe-na 139.34, 176.48 APE8-dihe-in -102.52, 110.93 APE8-rot-in 310.58 APE67-dihe-in -54.87, -25.59 -38.21, -52.86 APE12-dist-in 10.0158 APE11-dist-in 11.6891 APE10-dist-in 6.2662 APE9-dist-in 3.6553 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.92 0.219 0.266 B 327.0 289.0 7 30 27 3 [[183, 456]] 1.0 8v1o TKL_IRAK4_HUMAN TKL 5.5e-84 287.8 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8V1OC Q9NWZ3 163 459 460.0 Y9T:501 Type1 Inactive DFGin 6.9152 14.164 BLAminus -140.19, 169.04 68.79, 87.36 -108.28, 19.76 305.21, 96.76 -61.62, -32.73 in-out in 8.8991 Saltbr-out 4.0595 HRD-in -60.61, -59.09 78.04, 8.77 out-in-in SNCoii in-in ActLoopNT-in 2.776 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.34, 152.45 APE9-dihe-na 142.6, 179.16 APE8-dihe-in -102.2, 110.2 APE8-rot-in 311.46 APE67-dihe-in -56.49, -25.16 -38.09, -52.95 APE12-dist-in 9.9908 APE11-dist-in 11.5248 APE10-dist-in 6.209 APE9-dist-in 3.69 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.92 0.219 0.266 C 327.0 292.0 5 30 30 0 [[183, 456]] 1.0 8v1o TKL_IRAK4_HUMAN TKL 5.5e-84 287.8 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8V1OD Q9NWZ3 163 459 460.0 Y9T:501 Type1 Inactive DFGin 6.8497 14.2684 BLAminus -140.2, 169.66 70.3, 86.25 -107.86, 18.94 306.2, 96.68 -63.07, -30.17 in-out in 8.7571 Saltbr-out 4.0511 HRD-in -61.84, -59.06 77.97, 8.8 out-in-in SNCoii in-in ActLoopNT-in 2.7789 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.76, 152.94 APE9-dihe-na 140.97, 176.36 APE8-dihe-in -102.92, 110.82 APE8-rot-in 311.53 APE67-dihe-in -56.93, -25.15 -39.7, -51.03 APE12-dist-in 10.0789 APE11-dist-in 11.7528 APE10-dist-in 6.4009 APE9-dist-in 3.6968 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.92 0.219 0.266 D 327.0 288.0 9 30 25 5 [[183, 456]] 1.0 8v1o TKL_IRAK4_HUMAN TKL 5.5e-84 287.8 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8V2FA Q9NWZ3 163 459 460.0 YJU:60501 Type1 Inactive DFGin 6.8702 13.9122 BLAminus -130.46, 167.87 71.07, 88.15 -105.99, 14.17 306.33, 105.04 -63.43, -29.84 in-out in 8.7525 Saltbr-out 6.6469 HRD-in -75.59, -51.25 77.14, -1.53 out-in-in SNCoii in-in ActLoopNT-in 2.7595 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.46, 160.72 APE9-dihe-na 130.93, -172.56 APE8-dihe-in -109.8, 115.15 APE8-rot-in 307.79 APE67-dihe-in -64.1, -12.85 -49.44, -45.85 APE12-dist-in 9.9997 APE11-dist-in 11.6907 APE10-dist-in 6.2636 APE9-dist-in 3.8414 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.09 0.17 0.208 A 327.0 297.0 0 30 30 0 [[183, 456]] 1.0 8v2f TKL_IRAK4_HUMAN TKL 5.5e-84 287.8 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8V2FB Q9NWZ3 162 459 460.0 YJU:60501 Type1 Inactive DFGin 6.791 13.9203 BLAminus -128.51, 168.52 71.95, 86.21 -105.97, 13.84 307.27, 104.55 -61.45, -29.65 in-out in 8.6134 Saltbr-out 4.6866 HRD-in -73.0, -49.88 77.29, -2.9 out-in-in SNCoii in-in ActLoopNT-in 2.7666 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.29, 159.97 APE9-dihe-na 133.0, -176.78 APE8-dihe-in -107.14, 116.65 APE8-rot-in 305.27 APE67-dihe-in -65.9, -12.4 -47.02, -47.36 APE12-dist-in 9.8602 APE11-dist-in 11.7515 APE10-dist-in 6.2634 APE9-dist-in 3.7427 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.09 0.17 0.208 B 327.0 298.0 0 30 30 0 [[183, 456]] 1.0 8v2f TKL_IRAK4_HUMAN TKL 5.5e-84 287.8 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8V2FC Q9NWZ3 160 459 460.0 YJU:60501 Type1 Inactive DFGin 6.7489 13.9597 BLAminus -128.52, 169.77 69.32, 87.03 -106.73, 13.85 307.97, 104.15 -62.29, -28.75 in-out in 8.627 Saltbr-out 4.5488 HRD-in -75.43, -50.45 76.09, 0.63 out-in-in SNCoii in-in ActLoopNT-in 2.7812 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.14, 162.06 APE9-dihe-na 130.19, -174.89 APE8-dihe-in -108.77, 116.12 APE8-rot-in 305.67 APE67-dihe-in -65.6, -13.25 -47.01, -47.42 APE12-dist-in 9.8432 APE11-dist-in 11.6233 APE10-dist-in 6.0978 APE9-dist-in 3.7165 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.09 0.17 0.208 C 327.0 300.0 0 30 30 0 [[183, 456]] 1.0 8v2f TKL_IRAK4_HUMAN TKL 5.5e-84 287.8 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8V2FD Q9NWZ3 163 459 460.0 YJU:60501 Type1 Inactive DFGin 6.86 14.0001 BLAminus -128.26, 168.26 72.7, 86.48 -106.33, 14.33 307.69, 103.31 -60.7, -31.69 in-out in 8.8572 Saltbr-out 6.2889 HRD-in -76.04, -50.4 78.3, -1.88 out-in-in SNCoii in-in ActLoopNT-in 2.7509 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.81, 159.65 APE9-dihe-na 129.85, -177.51 APE8-dihe-in -108.36, 116.16 APE8-rot-in 308.63 APE67-dihe-in -62.97, -13.61 -47.53, -48.41 APE12-dist-in 10.0513 APE11-dist-in 11.8961 APE10-dist-in 6.3897 APE9-dist-in 3.7603 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.09 0.17 0.208 D 327.0 294.0 3 30 27 3 [[183, 456]] 1.0 8v2f TKL_IRAK4_HUMAN TKL 5.5e-84 287.8 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8V2LA Q9NWZ3 164 459 460.0 YK0:501 Type1 Inactive DFGin 6.6037 13.4056 BLAminus -121.21, 172.86 64.77, 85.79 -107.22, 18.27 310.33, 96.01 -58.61, -41.96 in-out in 8.0401 Saltbr-out 4.2802 HRD-in -62.46, -51.84 78.02, 3.1 out-in-in SNCoii in-in ActLoopNT-in 2.6112 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.97, 166.5 APE9-dihe-na 120.32, -177.29 APE8-dihe-in -108.05, 112.93 APE8-rot-in 310.64 APE67-dihe-in -64.75, -16.58 -36.82, -53.61 APE12-dist-in 9.3452 APE11-dist-in 11.3313 APE10-dist-in 5.8782 APE9-dist-in 3.2645 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.43 0.255 0.302 A 327.0 291.0 5 30 25 5 [[183, 456]] 1.0 8v2l TKL_IRAK4_HUMAN TKL 5.5e-84 287.8 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8V2LB Q9NWZ3 163 459 460.0 YK0:501 Type1 Inactive DFGin 6.6197 13.3492 BLAminus -120.96, 172.67 64.91, 85.77 -106.56, 17.9 310.1, 96.45 -58.62, -41.82 in-out in 7.9848 Saltbr-out 3.8758 HRD-in -62.59, -51.36 77.4, 3.79 out-in-in SNCoii in-in ActLoopNT-in 2.6128 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.09, 166.75 APE9-dihe-na 122.3, -175.29 APE8-dihe-in -107.71, 112.62 APE8-rot-in 309.44 APE67-dihe-in -64.15, -17.62 -36.19, -53.73 APE12-dist-in 9.2748 APE11-dist-in 11.2494 APE10-dist-in 5.7935 APE9-dist-in 3.2243 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.43 0.255 0.302 B 327.0 292.0 5 30 25 5 [[183, 456]] 1.0 8v2l TKL_IRAK4_HUMAN TKL 5.5e-84 287.8 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8V2LC Q9NWZ3 164 459 460.0 YK0:501 Type1 Inactive DFGin 6.5519 13.5417 BLAminus -121.25, 173.26 64.05, 86.32 -106.85, 17.63 309.75, 95.82 -58.65, -40.64 in-out in 7.9726 Saltbr-out 3.8686 HRD-in -62.33, -51.39 77.94, 3.4 out-in-in SNCoii in-in ActLoopNT-in 2.607 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.03, 167.23 APE9-dihe-na 120.49, -177.04 APE8-dihe-in -107.34, 112.53 APE8-rot-in 310.89 APE67-dihe-in -65.65, -16.07 -36.38, -53.95 APE12-dist-in 9.2763 APE11-dist-in 11.2987 APE10-dist-in 5.8444 APE9-dist-in 3.232 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.43 0.255 0.302 C 327.0 291.0 5 30 25 5 [[183, 456]] 1.0 8v2l TKL_IRAK4_HUMAN TKL 5.5e-84 287.8 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8V2LD Q9NWZ3 164 459 460.0 YK0:501 Type1 Inactive DFGin 6.5695 13.4784 BLAminus -121.17, 172.07 65.62, 86.14 -107.29, 16.86 310.43, 82.27 -58.81, -41.47 in-out in 7.8793 Saltbr-out 3.8558 HRD-in -62.38, -51.53 78.2, 3.12 out-in-in SNCoii in-in ActLoopNT-in 2.6133 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.11, 167.04 APE9-dihe-na 120.53, -178.59 APE8-dihe-in -107.42, 112.59 APE8-rot-in 311.17 APE67-dihe-in -65.49, -16.09 -36.28, -53.87 APE12-dist-in 9.5025 APE11-dist-in 11.3431 APE10-dist-in 5.9014 APE9-dist-in 3.2603 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.43 0.255 0.302 D 327.0 291.0 5 30 25 5 [[183, 456]] 1.0 8v2l TKL_IRAK4_HUMAN TKL 5.5e-84 287.8 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8ATBAAA Q9NWZ3 165 459 460.0 O0H:501 Type1 Inactive DFGin 6.9325 14.0449 BLAminus -121.47, 173.79 68.09, 102.5 -125.51, 19.89 306.28, 88.96 -63.31, -35.55 in-out in 9.0143 Saltbr-out 4.7306 HRD-in -76.64, -56.17 81.36, 1.11 out-in-in SNCoii in-in ActLoopNT-in 2.7117 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.25, 147.68 APE9-dihe-na 138.07, -176.27 APE8-dihe-in -102.25, 110.92 APE8-rot-in 311.13 APE67-dihe-in -58.31, -27.03 -61.07, -35.05 APE12-dist-in 10.3429 APE11-dist-in 11.7734 APE10-dist-in 6.4836 APE9-dist-in 4.0423 K400A,E401A,E402A TPO345,SEP346 CSO240,CSO289,TPO345,SEP346 XRAY 2.35 0.214 0.26 AAA 298.0 280.0 15 30 22 8 [[183, 456]] 1.0 8atb TKL_IRAK4_HUMAN TKL 1.3e-83 286.6 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8ATBBBB Q9NWZ3 165 459 460.0 O0H:501 Type1 Inactive DFGin 7.2148 13.7854 BLAminus -128.79, 170.66 65.65, 84.73 -111.53, 16.19 311.14, 85.88 -77.86, -13.48 in-out in 8.5669 Saltbr-out 7.2399 HRD-in -72.73, -56.78 83.28, 0.6 out-in-in SNCoii in-in ActLoopNT-in 2.6798 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.97, 161.24 APE9-dihe-na 134.69, -177.34 APE8-dihe-in -106.53, 101.49 APE8-rot-in 315.43 APE67-dihe-in -62.03, -21.88 -37.43, -49.3 APE12-dist-in 10.6974 APE11-dist-in 12.0305 APE10-dist-in 7.3801 APE9-dist-in 4.3329 K400A,E401A,E402A TPO345,SEP346 CSO240,CSO289,TPO345,SEP346 XRAY 2.35 0.214 0.26 BBB 298.0 282.0 13 30 24 6 [[183, 456]] 1.0 8atb TKL_IRAK4_HUMAN TKL 1.3e-83 286.6 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8ATNAAA Q9NWZ3 165 459 460.0 O06:1001 Type1 Inactive DFGin 6.7239 14.2081 BLAminus -117.77, 176.24 64.77, 96.31 -125.83, 10.5 313.57, 103.82 -69.05, -5.63 in-out in 8.6317 Saltbr-out 4.5649 HRD-in -69.73, -51.11 77.51, -5.14 out-in-in SNCoii in-in ActLoopNT-in 2.8391 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.0, 157.33 APE9-dihe-na 133.5, -162.12 APE8-dihe-in -121.39, 112.47 APE8-rot-in 318.21 APE67-dihe-in -71.32, -7.35 -41.66, -51.09 APE12-dist-in 9.9019 APE11-dist-in 12.0467 APE10-dist-in 7.0691 APE9-dist-in 3.8594 K400A,E401A,E402A TPO345,SEP346 TPO345,SEP346 XRAY 2.171 0.242 0.306 AAA 298.0 282.0 13 30 25 5 [[183, 456]] 1.0 8atn TKL_IRAK4_HUMAN TKL 1.3e-83 286.6 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8ATNBBB Q9NWZ3 165 459 460.0 O06:1001 Type1 Inactive DFGin 6.4704 14.0241 BLAminus -130.98, 162.78 71.1, 84.67 -104.49, 21.53 314.64, 81.97 -66.59, -34.68 in-out in 8.5199 Saltbr-out 5.3387 HRD-in -69.18, -52.19 77.12, 4.45 out-in-in SNCoii in-in ActLoopNT-in 2.5999 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.72, 153.2 APE9-dihe-na 145.05, 176.75 APE8-dihe-in -102.56, 117.31 APE8-rot-in 320.99 APE67-dihe-in -62.43, -13.54 -50.51, -47.21 APE12-dist-in 9.7364 APE11-dist-in 11.5133 APE10-dist-in 6.4449 APE9-dist-in 4.1015 K400A,E401A,E402A TPO345,SEP346 TPO345,SEP346 XRAY 2.171 0.242 0.306 BBB 298.0 286.0 9 30 27 3 [[183, 456]] 1.0 8atn TKL_IRAK4_HUMAN TKL 1.3e-83 286.6 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8BR6AAA Q9NWZ3 165 459 460.0 R6I:1001 Type1 Inactive DFGin 6.9174 13.8173 BLAminus -129.66, 170.0 69.62, 98.1 -122.85, 19.7 306.96, 88.76 -58.16, -37.07 in-out in 8.8089 Saltbr-out 7.4707 HRD-in -72.91, -58.78 84.26, 5.42 out-in-in SNCoii in-in ActLoopNT-in 2.7532 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.53, 152.76 APE9-dihe-na 145.18, -171.68 APE8-dihe-in -111.26, 112.24 APE8-rot-in 315.6 APE67-dihe-in -61.85, -25.79 -58.99, -34.36 APE12-dist-in 9.9925 APE11-dist-in 11.9713 APE10-dist-in 6.8577 APE9-dist-in 3.9736 K400A,E401A,E402A TPO345,SEP346 TPO345,SEP346 XRAY 2.167 0.215 0.251 AAA 298.0 288.0 7 30 23 7 [[183, 456]] 1.0 8br6 TKL_IRAK4_HUMAN TKL 1.3e-83 286.6 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8BR6BBB Q9NWZ3 165 459 460.0 R6I:1001 Type1 Inactive DFGin 7.2141 14.1156 BLAminus -122.04, 169.11 67.87, 99.68 -120.93, 27.62 310.0, 104.06 -68.88, -33.21 in-out in 9.2138 Saltbr-out 4.1674 HRD-in -70.69, -55.19 81.72, -1.09 out-in-in SNCoii in-in ActLoopNT-in 3.038 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.8, 91.66 APE9-dihe-na -148.3, -158.25 APE8-dihe-in -114.14, 110.31 APE8-rot-in 308.07 APE67-dihe-in -68.26, -15.15 -42.56, -51.42 APE12-dist-in 10.1107 APE11-dist-in 11.7081 APE10-dist-in 6.6862 APE9-dist-in 3.8899 K400A,E401A,E402A TPO345,SEP346 TPO345,SEP346 XRAY 2.167 0.215 0.251 BBB 298.0 278.0 17 30 24 6 [[183, 456]] 1.0 8br6 TKL_IRAK4_HUMAN TKL 1.3e-83 286.6 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8BR7AAA Q9NWZ3 165 458 460.0 R6R:501 Type1 Inactive DFGin 6.7483 13.7843 BLAminus -121.68, 175.13 64.52, 68.33 -88.96, 4.22 313.41, 97.24 -60.18, 142.14 in-out in 8.2357 Saltbr-out 7.7831 HRD-in -69.56, -54.74 85.52, -4.41 out-in-in SNCoii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.26, 163.97 APE9-dihe-na 117.6, -170.85 APE8-dihe-in -114.4, 114.65 APE8-rot-in 314.25 APE67-dihe-in -62.57, -14.8 -45.12, -53.09 APE12-dist-in 9.6098 APE11-dist-in 11.5218 APE10-dist-in 6.0807 APE9-dist-in 3.6881 K400A,E401A,E402A TPO345,SEP346 TPO345,SEP346 XRAY 2.119 0.241 0.288 AAA 298.0 273.0 21 30 24 6 [[183, 456]] 1.0 8br7 TKL_IRAK4_HUMAN TKL 1.3e-83 286.6 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8BR7BBB Q9NWZ3 165 458 460.0 R6R:501 Type1 Inactive DFGin 6.7251 14.0843 BLAminus -127.23, 169.57 70.93, 84.26 -111.93, 23.51 310.86, 94.87 -67.5, -27.24 in-out in 9.0787 Saltbr-out 4.6695 HRD-in -74.15, -52.75 85.58, -3.83 out-in-in SNCoii in-in ActLoopNT-in 2.7055 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.6, 148.06 APE9-dihe-na 139.81, -171.92 APE8-dihe-in -112.09, 123.4 APE8-rot-in 327.06 APE67-dihe-in -62.8, -13.81 -52.63, -52.65 APE12-dist-in 10.0265 APE11-dist-in 11.8292 APE10-dist-in 6.6234 APE9-dist-in 3.9928 K400A,E401A,E402A TPO345,SEP346 TPO345,SEP346 XRAY 2.119 0.241 0.288 BBB 298.0 278.0 16 30 25 5 [[183, 456]] 1.0 8br7 TKL_IRAK4_HUMAN TKL 1.3e-83 286.6 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8DKSA Q9NWZ3 165 459 460.0 SO9:501 Type1 Inactive DFGin 6.9825 14.0197 BLAminus -134.64, 178.03 63.45, 86.35 -110.27, 29.73 310.97, 98.17 -70.79, -35.85 in-out in 8.2912 Saltbr-out 4.4467 HRD-in -75.38, -48.79 72.8, 5.5 out-in-in SNCoii in-in ActLoopNT-in 2.9065 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.77, 162.36 APE9-dihe-na 128.07, -167.6 APE8-dihe-in -119.72, 111.55 APE8-rot-in 307.86 APE67-dihe-in -64.51, -15.13 -57.7, -32.23 APE12-dist-in 9.8577 APE11-dist-in 11.5245 APE10-dist-in 6.2214 APE9-dist-in 3.6652 None SEP346 SEP346 XRAY 2.45 0.215 0.267 A 460.0 283.0 12 30 23 7 [[183, 456]] 1.0 8dks TKL_IRAK4_HUMAN TKL 1.6e-83 286.6 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8DKSB Q9NWZ3 164 459 460.0 SO9:501 Type1 Inactive DFGin 7.0195 14.2623 BLAminus -133.36, 172.32 69.94, 86.94 -110.0, 21.28 306.52, 104.01 -69.01, -36.15 in-out in 8.4475 Saltbr-out 4.2848 HRD-in -74.58, -51.41 77.38, 3.56 out-in-in SNCoii in-in ActLoopNT-in 2.6651 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.18, 157.32 APE9-dihe-na 125.46, -172.72 APE8-dihe-in -116.19, 115.21 APE8-rot-in 297.6 APE67-dihe-in -69.09, -18.07 -48.21, -41.4 APE12-dist-in 10.1058 APE11-dist-in 11.7004 APE10-dist-in 6.2871 APE9-dist-in 3.8575 None SEP346 SEP346 XRAY 2.45 0.215 0.267 B 460.0 278.0 18 30 24 6 [[183, 456]] 1.0 8dks TKL_IRAK4_HUMAN TKL 1.6e-83 286.6 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8WTFA Q9NWZ3 165 458 460.0 8CG:501 Type1 Inactive DFGin 7.0053 14.5963 BLAminus -130.8, 171.92 71.01, 81.99 -105.62, 21.38 296.99, 92.96 -66.19, -26.61 in-out in 9.1924 Saltbr-out 4.6295 HRD-in -70.42, -54.47 79.43, 6.51 out-in-in SNCoii in-in ActLoopNT-in 2.8134 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.2, 140.94 APE9-dihe-na 161.87, -178.6 APE8-dihe-in -106.43, 100.35 APE8-rot-in 315.83 APE67-dihe-in -65.34, -20.2 -65.65, -27.46 APE12-dist-in 12.77 APE11-dist-in 10.937 APE10-dist-in 6.8234 APE9-dist-in 4.6698 None None None XRAY 2.0 0.183 0.236 A 297.0 291.0 3 30 30 0 [[183, 456]] 1.0 8wtf TKL_IRAK4_HUMAN TKL 2.5e-83 285.6 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6EGDD Q9NWZ3 164 458 460.0 J87:60501 Type1 Inactive DFGin 6.9187 14.3644 BLAminus -149.78, -167.55 62.28, 69.57 -94.25, 14.81 300.14, 101.17 -61.64, -25.96 in-out in 9.0927 Saltbr-out 3.605 HRD-in -74.47, -53.77 75.51, 2.5 out-in-none SNCoin in-none ActLoopNT-in 2.7234 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -71.85, -7.72 999.0, -32.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.184 0.23 D 302.0 274.0 21 30 14 16 [[183, 456]] 1.0 6egd TKL_IRAK4_HUMAN TKL 2.6e-83 285.5 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4YO6D Q9NWZ3 164 459 460.0 4GD:501,4GD:502 Type1,Allosteric Inactive DFGin 7.0074 13.7987 BLAminus -128.52, 178.14 61.39, 82.47 -106.01, 15.47 309.65, 100.13 -63.32, -35.07 in-out in 8.3085 Saltbr-out 4.1986 HRD-in -64.44, -53.47 79.17, -4.29 out-in-in SNCoii in-in ActLoopNT-in 2.6719 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.23, 153.2 APE9-dihe-na 136.75, -169.98 APE8-dihe-in -112.74, 114.12 APE8-rot-in 314.47 APE67-dihe-in -60.31, -19.69 -40.21, -53.83 APE12-dist-in 9.9637 APE11-dist-in 11.7421 APE10-dist-in 6.3209 APE9-dist-in 3.8609 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.32 0.199 0.225 D 301.0 288.0 8 30 26 4 [[183, 456]] 1.0 4yo6 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6TIAA Q9NWZ3 163 459 460.0 ND2:501,ND2:502,ND2:503,ND2:504 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 7.0563 14.7895 BLAminus -140.42, -178.87 56.13, 87.79 -104.25, 13.99 300.74, 95.94 -61.47, -11.04 in-out in 9.4587 Saltbr-out 6.4913 HRD-in -66.38, -48.88 73.85, 2.56 out-in-in SNCoii in-in ActLoopNT-in 2.803 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.91, 156.52 APE9-dihe-na 134.49, -171.44 APE8-dihe-in -101.75, 121.09 APE8-rot-in 313.72 APE67-dihe-in -68.2, -12.58 -55.04, -41.75 APE12-dist-in 10.3144 APE11-dist-in 11.8851 APE10-dist-in 6.4879 APE9-dist-in 3.5476 None TPO345,SEP346 TPO345,SEP346 XRAY 2.52 0.218 0.261 A 308.0 288.0 9 30 24 6 [[183, 456]] 1.0 6tia TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6TIAB Q9NWZ3 164 459 460.0 ND2:501,ND2:502,ND2:503,ND2:504 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 7.0823 14.767 BLAminus -129.53, 179.91 56.34, 87.3 -105.34, 14.83 301.91, 95.46 -60.96, -19.27 in-out in 9.2422 Saltbr-out 7.2036 HRD-in -65.06, -49.58 73.65, 2.87 out-in-in SNCoii in-in ActLoopNT-in 2.8143 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.9, 155.88 APE9-dihe-na 135.29, -171.62 APE8-dihe-in -102.71, 120.99 APE8-rot-in 315.19 APE67-dihe-in -67.65, -13.42 -54.79, -41.81 APE12-dist-in 10.2844 APE11-dist-in 11.9206 APE10-dist-in 6.518 APE9-dist-in 3.6049 None TPO345,SEP346 TPO345,SEP346 XRAY 2.52 0.218 0.261 B 308.0 287.0 9 30 24 6 [[183, 456]] 1.0 6tia TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 9R9KC Q9NWZ3 164 460 460.0 A1JDQ:501 Type1 Inactive DFGin 5.4273 13.7003 BLAplus -121.4, 174.92 52.96, 52.1 -113.08, 22.09 63.11, 100.55 -82.15, -34.43 in-in in 9.0044 Saltbr-in 3.5643 HRD-in -66.7, -51.75 79.98, -9.1 in-in-out SNCiio in-out ActLoopNT-in 2.8767 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -121.02, 159.56 APE9-dihe-na 135.26, -175.03 APE8-dihe-in -112.94, 115.11 APE8-rot-in 304.94 APE67-dihe-in -64.76, -11.9 -41.19, -51.22 APE12-dist-in 11.5011 APE11-dist-in 13.5883 APE10-dist-out 8.3502 APE9-dist-in 3.7071 None TPO345,SEP346 TPO345,SEP346 XRAY 1.87 0.216 0.242 C 308.0 287.0 10 30 25 5 [[183, 456]] 1.0 9r9k TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 2NRYA Q9NWZ3 164 458 460.0 STU:504 Type1 Inactive DFGin 7.0388 13.8495 BLBminus -119.68, 177.11 59.06, 71.69 -112.23, -126.05 350.98, 70.79 78.1, -70.69 in-in in 9.0302 Saltbr-in 2.7579 HRD-in -65.27, -50.09 77.33, -7.45 in-in-in SNCiii in-in ActLoopNT-in 2.7537 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.61, 161.22 APE9-dihe-na 128.42, -175.43 APE8-dihe-in -120.1, 117.97 APE8-rot-in 299.02 APE67-dihe-in -57.48, -21.15 -43.86, -55.05 APE12-dist-in 10.9882 APE11-dist-in 13.0534 APE10-dist-in 7.6703 APE9-dist-in 3.6824 None TPO345 TPO345 XRAY 2.15 0.212 0.261 A 307.0 287.0 8 30 25 5 [[183, 456]] 1.0 2nry TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 2NRYB Q9NWZ3 164 458 460.0 STU:502 Type1 Inactive DFGin 7.3303 14.2109 BLBminus -121.91, 179.32 63.59, 83.43 -104.91, -160.11 313.36, 100.13 93.41, -69.05 in-out in 8.9923 Saltbr-out 3.7751 HRD-in -74.38, -53.26 85.42, -10.52 out-in-in SNCoii in-in ActLoopNT-in 2.61 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.77, 162.03 APE9-dihe-na 124.37, -168.49 APE8-dihe-in -121.78, 111.1 APE8-rot-in 307.1 APE67-dihe-in -48.86, -28.56 -36.36, -56.5 APE12-dist-in 9.9324 APE11-dist-in 12.1379 APE10-dist-in 6.4849 APE9-dist-in 3.62 None TPO345 TPO345 XRAY 2.15 0.212 0.261 B 307.0 287.0 8 30 25 5 [[183, 456]] 1.0 2nry TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6EGFB Q9NWZ3 164 460 460.0 ANP:501 ATPlike Inactive DFGin 5.6133 16.8833 BLBtrans -116.63, 167.73 64.0, 27.84 -68.07, 138.11 161.96, 71.15 80.16, -16.86 out-out out 13.6461 Saltbr-out 13.3901 HRD-in -72.08, -42.87 70.74, 1.24 out-out-out SNCooo out-out ActLoopNT-out 6.1127 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 31.47 APE8-rot-out 178.98 APE67-dihe-in -65.08, -16.47 -76.23, -17.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.61 0.206 0.229 B 302.0 285.0 12 30 18 12 [[183, 456]] 1.0 6egf TKL_IRAK4_HUMAN TKL 2.6e-83 285.5 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8TVMD Q9NWZ3 164 459 460.0 VDC:501 Type1 Inactive DFGin 7.8031 14.7146 None -126.76, 170.55 55.84, 64.27 -89.21, 999.0 333.58, 116.07 999.0, 999.0 in-out in 9.0975 Saltbr-out 4.7491 HRD-in -67.23, -50.36 76.24, -8.64 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na -109.51, 116.74 APE9-dihe-na 179.74, -172.21 APE8-dihe-in -111.79, 118.52 APE8-rot-out 41.22 APE67-dihe-in -67.21, -19.62 -56.37, -42.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.276 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.223 0.246 D 307.0 277.0 19 30 19 11 [[183, 456]] 1.0 8tvm TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4U97B Q9NWZ3 166 458 460.0 STU:501 Type1 Inactive DFGin 5.2944 14.2173 None -136.34, -175.59 46.99, 62.58 -120.73, 999.0 61.34, 86.78 999.0, 999.0 in-in in 9.393 Saltbr-in 2.9962 HRD-in -71.9, -50.3 83.45, -13.24 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -128.91, -19.36 APE9-dihe-na -55.91, 145.79 APE8-dihe-in -64.15, 91.3 APE8-rot-in 291.9 APE67-dihe-in -57.49, -34.64 -51.29, -30.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.1454 D311N None None XRAY 2.65 0.206 0.251 B 312.0 270.0 23 30 18 12 [[183, 456]] 1.0 4u97 TKL_IRAK4_HUMAN TKL 3e-83 285.4 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4U9AB Q9NWZ3 166 458 460.0 STU:501 Type1 Inactive DFGin 5.6327 14.406 None -136.0, 173.79 77.97, 80.6 -165.88, 999.0 67.94, 103.04 999.0, 999.0 in-in in 9.4018 Saltbr-in 2.9242 HRD-in -69.54, -47.75 75.57, 5.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -138.84, -18.64 APE9-dihe-na -63.49, 153.65 APE8-dihe-in -64.27, 92.38 APE8-rot-in 304.32 APE67-dihe-in -63.41, -26.11 -54.68, -17.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.3588 D311N None None XRAY 2.8 0.185 0.24 B 312.0 270.0 23 30 18 12 [[183, 456]] 1.0 4u9a TKL_IRAK4_HUMAN TKL 3e-83 285.4 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6EG9A Q9NWZ3 164 459 460.0 0LI:501 Type2 Inactive DFGout 14.0712 10.7156 None -127.45, 167.3 -138.69, 101.47 -85.85, 140.23 309.7, 100.41 -43.19, 999.0 in-out in 9.0273 Saltbr-out 6.6465 HRD-in -71.51, -48.43 70.86, -5.67 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 6.91 APE9-dihe-na 158.59, -165.8 APE8-dihe-in -114.99, 116.82 APE8-rot-in 299.55 APE67-dihe-in -67.65, -20.43 -63.19, -29.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.972 None None None XRAY 2.414 0.224 0.249 A 312.0 276.0 20 30 13 17 [[183, 456]] 1.0 6eg9 TKL_IRAK4_HUMAN TKL 4.6e-84 288.0 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6EG9B Q9NWZ3 165 459 460.0 0LI:501 Type2 Inactive DFGout 14.2443 9.3953 None -135.81, 174.82 -152.29, 126.78 -163.75, 999.0 33.58, 60.29 999.0, 999.0 in-in in 8.9787 Saltbr-in 3.0904 HRD-in -69.81, -51.27 77.39, -7.02 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 146.5 APE9-dihe-na 95.5, 175.38 APE8-dihe-in -117.78, 118.94 APE8-rot-in 307.93 APE67-dihe-in -67.02, -18.64 -61.22, -30.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.6297 None None None XRAY 2.414 0.224 0.249 B 312.0 274.0 21 30 12 18 [[183, 456]] 1.0 6eg9 TKL_IRAK4_HUMAN TKL 4.6e-84 288.0 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6EGAA Q9NWZ3 166 459 460.0 J8A:501 Type2 Inactive DFGout 14.8372 9.221 None -132.87, 171.64 -143.22, 111.2 -89.3, 999.0 283.17, 56.87 999.0, 999.0 in-in in 8.4692 Saltbr-in 2.523 HRD-in -60.76, -42.87 73.04, -12.28 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnni APE10-dihe-na 999.0, -143.73 APE9-dihe-na -70.15, -161.11 APE8-dihe-out -111.74, -12.32 APE8-rot-in 304.14 APE67-dihe-out -73.29, -17.17 93.23, -43.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.6219 None None None XRAY 2.512 0.232 0.267 A 312.0 266.0 28 30 12 18 [[183, 456]] 1.0 6ega TKL_IRAK4_HUMAN TKL 4.6e-84 288.0 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6EGAB Q9NWZ3 164 459 460.0 J8A:501 Type2 Inactive DFGout 14.7494 10.183 None -139.75, 175.22 -156.01, 106.42 -83.08, 999.0 308.29, 92.5 999.0, 999.0 in-in in 8.7604 Saltbr-in 3.3724 HRD-in -65.42, -48.57 72.61, -7.89 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, -76.21 APE9-dihe-na 148.93, -171.19 APE8-dihe-in -115.49, 130.35 APE8-rot-in 312.15 APE67-dihe-in -70.04, -13.16 -55.8, -40.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.7443 None None None XRAY 2.512 0.232 0.267 B 312.0 269.0 27 30 12 18 [[183, 456]] 1.0 6ega TKL_IRAK4_HUMAN TKL 4.6e-84 288.0 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5KX7A Q9NWZ3 192 459 460.0 No_ligand No_ligand Inactive None 7.5134 999.0 None -138.26, 174.6 58.57, 81.01 -106.91, 34.11 322.12, 87.89 -72.06, -44.46 none-none none 999.0 Saltbr-none 999.0 HRD-in -69.47, -47.61 72.64, 1.38 none-in-in SNCnii in-in ActLoopNT-in 2.7601 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.3, 154.34 APE9-dihe-na 136.56, -175.85 APE8-dihe-in -106.22, 109.07 APE8-rot-in 305.46 APE67-dihe-in -59.17, -17.42 -32.79, -54.17 APE12-dist-in 9.9579 APE11-dist-in 11.4997 APE10-dist-in 6.1778 APE9-dist-in 3.7121 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.8 0.213 0.25 A 301.0 240.0 45 30 26 4 [[183, 456]] 1.0 5kx7 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8TVND Q9NWZ3 165 459 460.0 VE9:501 Type1 Inactive None 999.0 999.0 None -128.0, 174.48 59.07, 74.82 -91.46, 22.14 999.0, 999.0 -68.15, -32.2 in-in in 8.7182 Saltbr-in 3.5248 HRD-in -66.97, -47.07 77.91, -9.26 in-in-in SNCiii in-in ActLoopNT-in 2.7388 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.76, 163.35 APE9-dihe-na 134.11, -178.04 APE8-dihe-in -111.72, 122.92 APE8-rot-in 303.39 APE67-dihe-in -72.86, -10.54 -60.52, -36.73 APE12-dist-in 9.9407 APE11-dist-in 11.4617 APE10-dist-in 5.9919 APE9-dist-in 3.5874 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.95 0.208 0.242 D 307.0 286.0 9 30 24 6 [[183, 456]] 1.0 8tvn TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 2OICC Q9NWZ3 161 458 460.0 STU:3 Type1 None DFGin 7.6419 14.5124 BLAminus -134.38, -175.33 55.45, 88.83 -103.9, 2.57 299.42, 100.27 -42.77, 999.0 in-in in 9.1756 Saltbr-in 3.2966 HRD-in -70.98, -49.49 84.28, -16.44 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na -109.35, 145.04 APE9-dihe-na 142.04, -179.34 APE8-dihe-in -123.52, 118.39 APE8-rot-in 307.07 APE67-dihe-in -69.67, -21.31 -65.38, -24.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.5672 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 C 301.0 280.0 18 30 20 10 [[183, 456]] 1.0 2oic TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5K72B Q9NWZ3 165 458 460.0 6QY:504 Type1 None DFGin 6.9184 14.7968 BLAminus -126.83, 172.54 63.1, 86.46 -103.47, 19.92 308.93, 101.56 -64.92, -35.48 in-in in 8.8719 Saltbr-in 3.0871 HRD-in -67.63, -51.12 79.83, -9.89 in-in-none SNCiin in-none ActLoopNT-in 2.8692 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 146.4 APE9-dihe-na 138.09, -173.14 APE8-dihe-in -106.76, 111.81 APE8-rot-in 311.41 APE67-dihe-in -65.66, -17.88 -41.88, -47.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.4064 APE9-dist-in 4.0839 None TPO345,SEP346 TPO345,SEP346 XRAY 2.22 0.215 0.225 B 301.0 267.0 27 30 16 14 [[183, 456]] 1.0 5k72 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5K7GB Q9NWZ3 165 458 460.0 6R0:503 Type1 None DFGin 6.9828 14.5764 BLAminus -125.44, 169.29 65.46, 85.11 -103.67, 20.54 309.11, 102.13 -65.88, -35.43 in-in in 8.8953 Saltbr-in 3.1333 HRD-in -66.71, -50.75 79.24, -11.2 in-in-none SNCiin in-none ActLoopNT-in 2.8554 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 145.13 APE9-dihe-na 139.01, -174.96 APE8-dihe-in -106.13, 110.24 APE8-rot-in 312.27 APE67-dihe-in -64.1, -19.47 -39.24, -50.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.428 APE9-dist-in 4.132 None TPO345,SEP346 TPO345,SEP346 XRAY 2.23 0.207 0.227 B 301.0 275.0 19 30 16 14 [[183, 456]] 1.0 5k7g TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 5W84B Q9NWZ3 168 459 460.0 9YY:4000 Type1 None DFGin 6.9172 14.7775 BLAminus -117.28, -176.87 50.45, 80.34 -103.74, 13.5 304.16, 91.69 -70.56, -13.43 in-none in 8.5423 Saltbr-none 999.0 HRD-in -59.01, -48.84 73.66, 4.88 none-in-in SNCnii in-in ActLoopNT-in 2.7863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.28, 157.08 APE9-dihe-na 134.47, -164.72 APE8-dihe-in -110.39, 105.06 APE8-rot-in 309.52 APE67-dihe-in -62.58, -18.58 -39.91, -49.41 APE12-dist-in 9.8472 APE11-dist-in 12.1046 APE10-dist-in 6.8178 APE9-dist-in 3.6538 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.9 0.202 0.248 B 305.0 264.0 28 30 25 5 [[183, 456]] 1.0 5w84 TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6LXYB Q9NWZ3 163 459 460.0 EXF:502 Type1 None DFGin 6.9731 14.1366 BLAminus -129.45, 177.84 61.74, 86.54 -106.07, 12.43 306.08, 97.48 -57.61, -29.04 in-none in 9.0982 Saltbr-none 999.0 HRD-in -68.65, -53.21 75.68, 1.0 none-in-in SNCnii in-in ActLoopNT-in 2.8068 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.47, 149.33 APE9-dihe-na 135.3, -175.41 APE8-dihe-in -105.49, 112.4 APE8-rot-in 312.11 APE67-dihe-in -59.55, -21.17 -51.5, -42.55 APE12-dist-in 10.1894 APE11-dist-in 11.6864 APE10-dist-in 6.444 APE9-dist-in 4.3325 None TPO345,SEP346 TPO345,SEP346 XRAY 2.19 0.202 0.231 B 305.0 297.0 0 30 30 0 [[183, 456]] 1.0 6lxy TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 8TVMC Q9NWZ3 160 458 460.0 VDC:501 Type1 None DFGin 6.907 14.6736 BLAminus -124.23, 176.14 60.41, 68.85 -88.16, 21.88 308.01, 97.71 -66.33, -43.48 in-none in 8.8732 Saltbr-none 999.0 HRD-in -71.38, -49.64 77.01, -7.35 none-in-in SNCnii in-in ActLoopNT-in 2.6838 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.63, 156.99 APE9-dihe-na 140.7, -171.01 APE8-dihe-in -113.25, 123.93 APE8-rot-in 312.17 APE67-dihe-in -64.66, -21.4 -62.46, -37.14 APE12-dist-in 9.7991 APE11-dist-in 11.1869 APE10-dist-in 6.2459 APE9-dist-in 3.9943 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.223 0.246 C 307.0 281.0 18 30 24 6 [[183, 456]] 1.0 8tvm TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6EGDA Q9NWZ3 165 458 460.0 J87:60501 Type1 None DFGin 6.8485 14.1837 BLAminus -141.24, -173.92 62.73, 75.05 -96.24, 8.11 294.89, 87.75 -42.03, -35.64 in-in in 8.8336 Saltbr-in 3.375 HRD-in -75.12, -50.55 72.64, 0.08 in-in-none SNCiin in-none ActLoopNT-in 2.6778 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -63.37, -20.6 999.0, -46.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.184 0.23 A 302.0 268.0 26 30 14 16 [[183, 456]] 1.0 6egd TKL_IRAK4_HUMAN TKL 2.6e-83 285.5 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 6EGED Q9NWZ3 164 457 460.0 DL1:60501 Type1 None DFGin 6.4849 13.7691 BLAminus -131.26, -173.55 62.72, 71.71 -99.41, 12.5 304.64, 98.46 -67.05, -20.52 in-in in 8.9822 Saltbr-in 2.9789 HRD-in -74.07, -47.83 71.86, 0.89 in-in-none SNCiin in-none ActLoopNT-in 2.6901 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -66.83, -16.12 999.0, -13.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.401 0.179 0.201 D 302.0 282.0 12 30 25 5 [[183, 456]] 1.0 6ege TKL_IRAK4_HUMAN TKL 2.6e-83 285.5 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4U97A Q9NWZ3 166 458 460.0 STU:501 Type1 None DFGin 7.218 14.4948 BLAminus -133.4, -177.52 44.45, 65.76 -75.86, 30.58 295.34, 78.33 -61.24, -17.68 in-in in 9.1113 Saltbr-in 2.7963 HRD-in -81.28, -51.43 74.22, 0.69 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.32, 150.98 APE9-dihe-na 154.49, -177.45 APE8-dihe-in -96.07, 115.4 APE8-rot-in 303.66 APE67-dihe-in -67.54, -17.85 -61.65, -28.02 APE12-dist-in 9.909 APE11-dist-in 11.8395 APE10-dist-in 7.0324 APE9-dist-in 3.8244 D311N None None XRAY 2.65 0.206 0.251 A 312.0 272.0 21 30 22 8 [[183, 456]] 1.0 4u97 TKL_IRAK4_HUMAN TKL 3e-83 285.4 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 4U9AA Q9NWZ3 166 458 460.0 STU:501 Type1 None DFGin 7.0448 14.9069 BLAminus -101.08, -157.39 29.3, 88.18 -95.05, 25.51 282.71, 82.79 -64.14, 4.87 in-in in 8.9978 Saltbr-in 3.2256 HRD-in -68.43, -44.05 62.5, 13.64 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.36, 146.03 APE9-dihe-na 162.68, -156.1 APE8-dihe-in -121.4, 112.37 APE8-rot-in 316.45 APE67-dihe-in -59.48, -18.83 -58.3, -38.15 APE12-dist-in 9.9834 APE11-dist-in 11.9507 APE10-dist-in 7.2186 APE9-dist-in 3.878 D311N None None XRAY 2.8 0.185 0.24 A 312.0 272.0 21 30 22 8 [[183, 456]] 1.0 4u9a TKL_IRAK4_HUMAN TKL 3e-83 285.4 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4

TKL_IRAK4 (Interleukin-1 receptor-associated kinase 4)

Total number of chains: 284
Active chains: 87
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 271 95.4% AF-Q9NWZ3-K1A
DFGout None 4 1.4% 6EG9A
DFGin None 3 1.1% 8TVMD
DFGin BLBminus 2 0.7% 2NRYA
None None 2 0.7% 8TVND
DFGin BLAplus 1 0.4% 9R9KC
DFGin BLBtrans 1 0.4% 6EGFB

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
IRAK4 IRAK4_HUMAN 2OIDD Q9NWZ3 164 459 460.0 ANP:4 ATPlike Active DFGin 6.5602 13.9721 BLAminus -129.12, -177.03 59.13, 109.88 -131.38, 17.54 304.54, 87.5 -68.37, -4.63 in-in in 8.1503 Saltbr-in 3.5198 HRD-in -75.54, -51.34 70.58, 2.03 in-in-in SNCiii in-in ActLoopNT-in 2.7649 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.72, 147.52 APE9-dihe-na 139.0, -173.6 APE8-dihe-in -107.1, 118.58 APE8-rot-in 309.04 APE67-dihe-in -62.68, -15.82 -47.4, -49.91 APE12-dist-in 9.7501 APE11-dist-in 11.4404 APE10-dist-in 5.9279 APE9-dist-in 3.9698 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.244 0.295 D 301.0 277.0 19 30 27 3 [[183, 456]] 1.0 2oid Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN AF-Q9NWZ3-K1A Q9NWZ3 167 460 460.0 No_ligand No_ligand Active DFGin 6.8118 13.6643 BLAminus -132.76, 172.69 67.25, 69.59 -89.82, 12.24 307.87, 90.6 -59.49, -31.68 in-in in 8.8545 Saltbr-in 3.3486 HRD-in -71.59, -45.27 70.03, -5.05 in-in-in SNCiii in-in ActLoopNT-in 2.871 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.66, 156.28 APE9-dihe-na 122.41, 177.96 APE8-dihe-in -94.38, 113.56 APE8-rot-in 308.42 APE67-dihe-in -63.16, -15.22 -47.64, -42.49 APE12-dist-in 9.9128 APE11-dist-in 11.7505 APE10-dist-in 6.2739 APE9-dist-in 3.8166 None None None AF2 -1.0 1.0 1.0 A 294.0 294.0 0 30 30 0 [[183, 456]] 1.0 AF-Q9NWZ3-K1 Homo sapiens TKL_IRAK4_HUMAN TKL 3.7e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN AF-Q9NWZ3-K3A Q9NWZ3 167 460 460.0 No_ligand No_ligand Active DFGin 6.7864 14.0038 BLAminus -132.19, 177.79 65.89, 57.73 -81.1, 6.78 299.4, 89.77 -58.62, -25.66 in-in in 8.8744 Saltbr-in 3.0276 HRD-in -74.86, -42.43 71.98, -8.96 in-in-in SNCiii in-in ActLoopNT-in 2.8504 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.5, 149.42 APE9-dihe-na 114.46, -176.54 APE8-dihe-in -91.44, 118.0 APE8-rot-in 299.76 APE67-dihe-in -61.58, -17.39 -51.41, -39.95 APE12-dist-in 10.2044 APE11-dist-in 11.6384 APE10-dist-in 6.1636 APE9-dist-in 4.2957 None None None AF2 -1.0 1.0 1.0 A 294.0 294.0 0 30 30 0 [[183, 456]] 1.0 AF-Q9NWZ3-K3 Homo sapiens TKL_IRAK4_HUMAN TKL 3.7e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 2OIBA Q9NWZ3 162 458 460.0 No_ligand No_ligand Active DFGin 7.2364 14.0842 BLAminus -134.16, -176.28 54.93, 81.04 -100.11, 21.09 297.23, 89.01 -65.48, -18.31 in-in in 9.1219 Saltbr-in 2.8468 HRD-in -68.64, -53.67 81.53, -4.3 in-in-in SNCiii in-in ActLoopNT-in 2.6863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.86, 156.66 APE9-dihe-na 135.28, -174.63 APE8-dihe-in -110.16, 113.63 APE8-rot-in 304.76 APE67-dihe-in -68.16, -10.88 -49.28, -45.36 APE12-dist-in 10.0718 APE11-dist-in 11.7658 APE10-dist-in 6.4573 APE9-dist-in 3.9204 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.0 0.224 0.27 A 301.0 283.0 14 30 26 4 [[183, 456]] 1.0 2oib Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 2OIBC Q9NWZ3 161 458 460.0 No_ligand No_ligand Active DFGin 6.7825 13.9217 BLAminus -128.61, -179.25 54.07, 81.1 -99.0, 24.35 303.67, 85.85 -70.18, -11.07 in-in in 9.001 Saltbr-in 2.7478 HRD-in -69.66, -51.82 77.63, -0.65 in-in-in SNCiii in-in ActLoopNT-in 2.7889 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.16, 161.47 APE9-dihe-na 128.44, -177.87 APE8-dihe-in -108.48, 112.83 APE8-rot-in 306.45 APE67-dihe-in -63.49, -17.45 -45.36, -47.81 APE12-dist-in 9.7554 APE11-dist-in 11.7364 APE10-dist-in 6.1609 APE9-dist-in 3.6923 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.0 0.224 0.27 C 301.0 281.0 17 30 26 4 [[183, 456]] 1.0 2oib Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6F3GA Q9NWZ3 164 458 460.0 CJN:501 Type1 Active DFGin 6.9344 14.6905 BLAminus -122.32, 172.07 57.35, 82.28 -97.19, 19.83 304.44, 114.9 -63.17, -27.04 in-in in 9.3591 Saltbr-in 3.2345 HRD-in -67.41, -50.37 77.63, -5.5 in-in-in SNCiii in-in ActLoopNT-in 2.8163 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.97, 162.51 APE9-dihe-na 125.59, -169.48 APE8-dihe-in -113.67, 112.77 APE8-rot-in 308.62 APE67-dihe-in -62.16, -14.53 -45.05, -47.73 APE12-dist-in 10.3673 APE11-dist-in 11.9291 APE10-dist-in 6.368 APE9-dist-in 3.7361 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.37 0.291 0.314 A 295.0 277.0 18 30 24 6 [[183, 456]] 1.0 6f3g Homo sapiens TKL_IRAK4_HUMAN TKL 3.8e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6F3GB Q9NWZ3 164 458 460.0 CJN:502 Type1 Active DFGin 6.7463 14.91 BLAminus -124.8, 172.93 59.11, 81.24 -96.73, 18.74 302.18, 100.23 -62.68, -27.88 in-in in 9.5668 Saltbr-in 3.2461 HRD-in -66.44, -50.77 77.64, -6.42 in-in-in SNCiii in-in ActLoopNT-in 2.8172 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.34, 162.98 APE9-dihe-na 126.47, -168.92 APE8-dihe-in -114.13, 114.0 APE8-rot-in 308.7 APE67-dihe-in -62.55, -14.66 -47.56, -45.83 APE12-dist-in 10.3152 APE11-dist-in 11.7999 APE10-dist-in 6.2953 APE9-dist-in 3.7574 None TPO345,SEP346 TPO345,SEP346 XRAY 2.37 0.291 0.314 B 295.0 279.0 16 30 24 6 [[183, 456]] 1.0 6f3g Homo sapiens TKL_IRAK4_HUMAN TKL 3.8e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6N8GA Q9NWZ3 164 459 460.0 KFD:501 Type1 Active DFGin 6.8567 13.8503 BLAminus -131.56, 170.5 74.43, 93.31 -112.82, 5.9 310.67, 99.35 -50.67, -35.36 in-in in 8.7028 Saltbr-in 3.3998 HRD-in -74.01, -49.56 80.73, -4.62 in-in-in SNCiii in-in ActLoopNT-in 2.7886 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.5, 156.4 APE9-dihe-na 134.1, -163.0 APE8-dihe-in -125.24, 115.56 APE8-rot-in 300.55 APE67-dihe-in -58.51, -21.49 -57.72, -36.7 APE12-dist-in 9.8814 APE11-dist-in 11.9887 APE10-dist-in 6.4694 APE9-dist-in 3.5414 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.0 0.177 0.22 A 297.0 288.0 8 30 26 4 [[183, 456]] 1.0 6n8g Homo sapiens TKL_IRAK4_HUMAN TKL 3.9e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6N8GC Q9NWZ3 164 459 460.0 KFD:501 Type1 Active DFGin 6.674 13.7674 BLAminus -132.63, 173.5 73.5, 89.42 -109.51, 12.57 307.44, 107.33 -58.55, -28.35 in-in in 8.8096 Saltbr-in 3.3471 HRD-in -80.2, -52.37 80.38, -6.83 in-in-in SNCiii in-in ActLoopNT-in 2.8023 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.29, 155.42 APE9-dihe-na 139.08, -169.18 APE8-dihe-in -120.47, 120.87 APE8-rot-in 299.74 APE67-dihe-in -68.05, -14.89 -52.69, -42.94 APE12-dist-in 10.023 APE11-dist-in 11.9495 APE10-dist-in 6.3533 APE9-dist-in 3.6611 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.0 0.177 0.22 C 297.0 289.0 7 30 26 4 [[183, 456]] 1.0 6n8g Homo sapiens TKL_IRAK4_HUMAN TKL 3.9e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6N8GD Q9NWZ3 164 459 460.0 KFD:501 Type1 Active DFGin 6.8489 14.0366 BLAminus -133.11, 174.94 69.68, 87.35 -112.0, 19.02 309.42, 96.14 -69.47, -26.65 in-in in 8.4657 Saltbr-in 3.0627 HRD-in -74.85, -48.34 77.85, -6.98 in-in-in SNCiii in-in ActLoopNT-in 2.9429 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.26, 155.15 APE9-dihe-na 138.35, -169.27 APE8-dihe-in -119.34, 119.24 APE8-rot-in 303.95 APE67-dihe-in -65.64, -14.54 -58.36, -38.59 APE12-dist-in 9.773 APE11-dist-in 11.8987 APE10-dist-in 6.4105 APE9-dist-in 3.7994 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.0 0.177 0.22 D 297.0 280.0 16 30 25 5 [[183, 456]] 1.0 6n8g Homo sapiens TKL_IRAK4_HUMAN TKL 3.9e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 7C2VA Q9NWZ3 163 459 460.0 FJ0:62001 Type1 Active DFGin 6.6176 14.2134 BLAminus -135.94, 175.42 58.24, 84.61 -104.43, 24.97 312.74, 88.43 -59.88, -37.17 in-in in 8.7453 Saltbr-in 3.002 HRD-in -74.11, -52.44 77.01, 1.32 in-in-in SNCiii in-in ActLoopNT-in 2.8156 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.63, 154.75 APE9-dihe-na 139.65, -164.04 APE8-dihe-in -119.02, 113.97 APE8-rot-in 308.25 APE67-dihe-in -69.21, -17.36 -47.12, -47.85 APE12-dist-in 10.0224 APE11-dist-in 11.7235 APE10-dist-in 6.4158 APE9-dist-in 3.9472 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.44 0.198 0.253 A 300.0 289.0 8 30 26 4 [[183, 456]] 1.0 7c2v Homo sapiens TKL_IRAK4_HUMAN TKL 4e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 7C2VB Q9NWZ3 162 459 460.0 FJ0:62001 Type1 Active DFGin 6.6654 14.2521 BLAminus -135.26, 175.48 59.27, 84.88 -104.92, 25.84 312.32, 88.52 -63.18, -35.5 in-in in 8.6997 Saltbr-in 2.9903 HRD-in -74.07, -51.98 78.02, -1.39 in-in-in SNCiii in-in ActLoopNT-in 2.8117 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.61, 154.63 APE9-dihe-na 138.13, -164.33 APE8-dihe-in -118.3, 113.67 APE8-rot-in 307.85 APE67-dihe-in -69.26, -16.84 -48.23, -46.76 APE12-dist-in 10.0425 APE11-dist-in 11.779 APE10-dist-in 6.4215 APE9-dist-in 3.9206 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.44 0.198 0.253 B 300.0 283.0 15 30 25 5 [[183, 456]] 1.0 7c2v Homo sapiens TKL_IRAK4_HUMAN TKL 4e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 7C2VC Q9NWZ3 164 460 460.0 FJ0:62001 Type1 Active DFGin 6.712 14.089 BLAminus -135.73, 175.29 58.82, 84.49 -103.99, 25.78 313.96, 89.54 -62.7, -36.78 in-in in 8.7629 Saltbr-in 2.9984 HRD-in -73.62, -52.52 77.93, -0.03 in-in-in SNCiii in-in ActLoopNT-in 2.8182 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.21, 152.15 APE9-dihe-na 142.56, -163.31 APE8-dihe-in -117.7, 113.89 APE8-rot-in 308.41 APE67-dihe-in -67.4, -19.19 -47.53, -47.66 APE12-dist-in 10.0468 APE11-dist-in 11.7965 APE10-dist-in 6.4267 APE9-dist-in 3.9165 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.44 0.198 0.253 C 300.0 283.0 14 30 25 5 [[183, 456]] 1.0 7c2v Homo sapiens TKL_IRAK4_HUMAN TKL 4e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 7C2VD Q9NWZ3 164 459 460.0 FJ0:62001 Type1 Active DFGin 6.8435 13.991 BLAminus -135.79, 174.86 59.77, 84.88 -105.31, 25.28 314.76, 91.39 -66.34, -34.97 in-in in 8.5374 Saltbr-in 3.2341 HRD-in -74.76, -52.59 77.74, -0.48 in-in-in SNCiii in-in ActLoopNT-in 2.818 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.65, 153.85 APE9-dihe-na 138.77, -167.25 APE8-dihe-in -118.33, 113.46 APE8-rot-in 308.03 APE67-dihe-in -67.8, -17.81 -49.08, -46.8 APE12-dist-in 9.9954 APE11-dist-in 11.7907 APE10-dist-in 6.4908 APE9-dist-in 3.9523 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.44 0.198 0.253 D 300.0 286.0 10 30 26 4 [[183, 456]] 1.0 7c2v Homo sapiens TKL_IRAK4_HUMAN TKL 4e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 2OICA Q9NWZ3 163 458 460.0 STU:1 Type1 Active DFGin 7.5415 14.5501 BLAminus -120.17, -157.79 43.1, 78.64 -95.77, 16.12 291.84, 81.73 -52.42, -46.68 in-in in 9.1643 Saltbr-in 2.7447 HRD-in -70.7, -51.8 81.1, -5.15 in-in-in SNCiii in-in ActLoopNT-in 2.8301 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.11, 162.72 APE9-dihe-na 127.09, -176.82 APE8-dihe-in -109.75, 123.25 APE8-rot-in 303.17 APE67-dihe-in -63.31, -16.61 -48.06, -48.45 APE12-dist-in 10.1333 APE11-dist-in 11.7238 APE10-dist-in 6.3469 APE9-dist-in 3.4459 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 A 301.0 279.0 17 30 24 6 [[183, 456]] 1.0 2oic Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 2OICB Q9NWZ3 164 459 460.0 STU:2 Type1 Active DFGin 7.3007 14.318 BLAminus -135.72, -165.01 43.24, 86.39 -100.56, 27.64 301.91, 89.45 -68.65, -40.8 in-in in 8.997 Saltbr-in 3.0216 HRD-in -70.79, -51.12 80.52, -12.66 in-in-in SNCiii in-in ActLoopNT-in 2.8485 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.84, 167.54 APE9-dihe-na 125.4, -168.64 APE8-dihe-in -121.45, 120.26 APE8-rot-in 302.84 APE67-dihe-in -66.81, -13.26 -49.44, -48.37 APE12-dist-in 10.0934 APE11-dist-in 11.7177 APE10-dist-in 6.031 APE9-dist-in 3.6867 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 B 301.0 278.0 18 30 24 6 [[183, 456]] 1.0 2oic Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 2OICD Q9NWZ3 161 459 460.0 STU:4 Type1 Active DFGin 6.9643 14.7946 BLAminus -128.12, -176.74 47.11, 78.66 -89.74, 11.31 298.87, 93.52 -54.67, -36.62 in-in in 8.7014 Saltbr-in 2.6141 HRD-in -65.25, -53.17 80.56, 0.44 in-in-in SNCiii in-in ActLoopNT-in 2.8622 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.06, 151.9 APE9-dihe-na 143.33, 177.59 APE8-dihe-in -104.02, 127.84 APE8-rot-in 302.2 APE67-dihe-in -61.5, -18.42 -54.54, -50.36 APE12-dist-in 10.5716 APE11-dist-in 11.6739 APE10-dist-in 6.1102 APE9-dist-in 3.4836 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 D 301.0 287.0 12 30 28 2 [[183, 456]] 1.0 2oic Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4XS2B Q9NWZ3 161 459 460.0 42P:501 Type1 Active DFGin 7.0765 13.8865 BLAminus -139.83, 178.8 62.52, 89.3 -111.11, 32.77 305.23, 93.71 -72.57, -32.59 in-in in 8.756 Saltbr-in 3.1307 HRD-in -65.98, -47.74 71.13, 8.5 in-in-in SNCiii in-in ActLoopNT-in 2.9047 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.99, 146.9 APE9-dihe-na 152.01, -163.09 APE8-dihe-in -121.37, 101.63 APE8-rot-in 312.25 APE67-dihe-in -59.65, -26.7 -31.84, -51.61 APE12-dist-in 10.1773 APE11-dist-in 11.5738 APE10-dist-in 6.3629 APE9-dist-in 3.9021 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.73 0.265 0.285 B 301.0 281.0 18 30 23 7 [[183, 456]] 1.0 4xs2 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4YO6B Q9NWZ3 161 459 460.0 4GD:501 Type1 Active DFGin 6.9838 14.018 BLAminus -128.18, 178.21 60.04, 83.58 -106.22, 16.8 308.81, 100.39 -62.55, -37.23 in-in in 8.3444 Saltbr-in 3.3581 HRD-in -63.56, -52.38 78.12, -4.13 in-in-in SNCiii in-in ActLoopNT-in 2.8182 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.99, 155.41 APE9-dihe-na 134.98, -169.72 APE8-dihe-in -112.68, 114.11 APE8-rot-in 315.54 APE67-dihe-in -60.97, -21.48 -39.7, -53.59 APE12-dist-in 9.9188 APE11-dist-in 11.7342 APE10-dist-in 6.2806 APE9-dist-in 3.7727 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.32 0.199 0.225 B 301.0 280.0 19 30 24 6 [[183, 456]] 1.0 4yo6 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4YP8A Q9NWZ3 164 459 460.0 4GF:501 Type1 Active DFGin 6.842 14.1629 BLAminus -130.64, 178.89 61.7, 76.88 -103.53, 25.67 310.66, 96.36 -67.74, -31.55 in-in in 8.7784 Saltbr-in 3.5486 HRD-in -57.79, -50.73 76.7, -3.88 in-in-in SNCiii in-in ActLoopNT-in 2.7748 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.21, 150.97 APE9-dihe-na 140.01, -173.97 APE8-dihe-in -103.61, 115.43 APE8-rot-in 309.9 APE67-dihe-in -66.28, -16.88 -42.43, -50.13 APE12-dist-in 10.0082 APE11-dist-in 11.614 APE10-dist-in 6.3264 APE9-dist-in 3.9176 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 A 301.0 287.0 9 30 26 4 [[183, 456]] 1.0 4yp8 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4ZTLA Q9NWZ3 165 459 460.0 4S1:501 Type1 Active DFGin 7.2485 13.3584 BLAminus -117.91, 179.25 56.88, 97.36 -119.29, 25.75 307.86, 91.56 -68.49, -33.91 in-in in 8.0261 Saltbr-in 2.7435 HRD-in -66.32, -51.9 77.7, -4.43 in-in-in SNCiii in-in ActLoopNT-in 3.0325 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.4, 151.93 APE9-dihe-na 136.96, -167.86 APE8-dihe-in -115.05, 113.79 APE8-rot-in 311.31 APE67-dihe-in -63.05, -18.96 -38.32, -54.3 APE12-dist-in 9.9062 APE11-dist-in 11.7132 APE10-dist-in 6.3075 APE9-dist-in 3.7399 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.39 0.226 0.251 A 301.0 283.0 12 30 23 7 [[183, 456]] 1.0 4ztl Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4ZTLB Q9NWZ3 165 459 460.0 4S1:501 Type1 Active DFGin 7.3657 13.505 BLAminus -117.83, 179.65 56.5, 97.62 -119.39, 25.81 307.63, 91.72 -68.25, -34.25 in-in in 8.4246 Saltbr-in 2.8595 HRD-in -65.94, -51.9 77.53, -3.95 in-in-in SNCiii in-in ActLoopNT-in 3.0208 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.04, 153.48 APE9-dihe-na 136.39, -168.5 APE8-dihe-in -114.87, 114.24 APE8-rot-in 310.51 APE67-dihe-in -62.87, -18.96 -38.44, -53.72 APE12-dist-in 9.9024 APE11-dist-in 11.6832 APE10-dist-in 6.2716 APE9-dist-in 3.725 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.39 0.226 0.251 B 301.0 272.0 23 30 24 6 [[183, 456]] 1.0 4ztl Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4ZTLC Q9NWZ3 164 460 460.0 4S1:501 Type1 Active DFGin 7.1204 13.7358 BLAminus -116.77, 179.72 56.78, 97.16 -118.74, 26.23 307.1, 91.38 -67.56, -34.29 in-in in 8.5247 Saltbr-in 3.5919 HRD-in -66.63, -52.32 77.27, -3.33 in-in-in SNCiii in-in ActLoopNT-in 2.7645 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.73, 154.17 APE9-dihe-na 136.59, -168.35 APE8-dihe-in -115.05, 114.89 APE8-rot-in 308.8 APE67-dihe-in -61.95, -19.73 -39.55, -53.38 APE12-dist-in 9.6829 APE11-dist-in 11.6786 APE10-dist-in 6.2916 APE9-dist-in 3.7394 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.39 0.226 0.251 C 301.0 285.0 12 30 26 4 [[183, 456]] 1.0 4ztl Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4ZTMA Q9NWZ3 162 459 460.0 4S2:501 Type1 Active DFGin 6.8411 14.0035 BLAminus -126.65, 176.49 62.86, 88.68 -111.82, 16.17 306.42, 93.16 -61.8, -39.01 in-in in 8.6752 Saltbr-in 3.5039 HRD-in -66.09, -48.54 74.54, -1.58 in-in-in SNCiii in-in ActLoopNT-in 2.6621 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.13, 150.6 APE9-dihe-na 137.15, -172.25 APE8-dihe-in -111.72, 110.91 APE8-rot-in 308.99 APE67-dihe-in -63.61, -18.06 -39.97, -47.58 APE12-dist-in 9.7817 APE11-dist-in 11.6895 APE10-dist-in 6.2377 APE9-dist-in 3.84 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.66 0.195 0.226 A 301.0 290.0 8 30 27 3 [[183, 456]] 1.0 4ztm Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4ZTMB Q9NWZ3 161 459 460.0 4S2:501 Type1 Active DFGin 6.949 13.8532 BLAminus -125.14, 175.8 64.22, 86.81 -111.57, 16.58 307.7, 93.22 -64.41, -38.21 in-in in 8.1073 Saltbr-in 3.2761 HRD-in -68.42, -47.04 74.05, -1.81 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.65, 151.81 APE9-dihe-na 136.32, -173.24 APE8-dihe-in -111.48, 109.87 APE8-rot-in 308.84 APE67-dihe-in -65.88, -16.61 -38.33, -48.13 APE12-dist-in 9.8545 APE11-dist-in 11.6677 APE10-dist-in 6.2266 APE9-dist-in 3.8116 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.66 0.195 0.226 B 301.0 283.0 16 30 24 6 [[183, 456]] 1.0 4ztm Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4ZTMD Q9NWZ3 164 459 460.0 4S2:501 Type1 Active DFGin 7.3251 14.0535 BLAminus -123.99, 176.44 63.13, 88.09 -113.68, 22.11 303.38, 91.55 -67.04, -38.41 in-in in 8.4641 Saltbr-in 3.3579 HRD-in -67.68, -48.45 75.88, -3.34 in-in-in SNCiii in-in ActLoopNT-in 2.6773 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.43, 151.52 APE9-dihe-na 136.49, -173.1 APE8-dihe-in -111.23, 109.28 APE8-rot-in 305.91 APE67-dihe-in -63.51, -17.43 -35.93, -49.7 APE12-dist-in 9.8849 APE11-dist-in 11.7058 APE10-dist-in 6.2608 APE9-dist-in 3.8589 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.66 0.195 0.226 D 301.0 285.0 11 30 25 5 [[183, 456]] 1.0 4ztm Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4ZTNB Q9NWZ3 161 459 460.0 4S3:501 Type1 Active DFGin 7.1545 13.7575 BLAminus -131.99, 175.82 63.87, 82.48 -105.73, 21.47 308.39, 101.43 -66.39, -41.59 in-in in 8.5507 Saltbr-in 3.2983 HRD-in -64.32, -51.43 76.6, -0.44 in-in-in SNCiii in-in ActLoopNT-in 2.7675 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.02, 158.22 APE9-dihe-na 130.01, -170.09 APE8-dihe-in -112.61, 111.91 APE8-rot-in 309.6 APE67-dihe-in -62.86, -20.33 -37.78, -52.13 APE12-dist-in 9.8586 APE11-dist-in 11.7313 APE10-dist-in 6.2358 APE9-dist-in 3.8196 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.23 0.21 0.224 B 301.0 285.0 14 30 26 4 [[183, 456]] 1.0 4ztn Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5K72A Q9NWZ3 164 458 460.0 6QY:503 Type1 Active DFGin 6.8759 14.7895 BLAminus -129.6, 174.26 62.65, 87.42 -104.23, 19.84 308.29, 101.45 -64.94, -30.93 in-in in 8.9263 Saltbr-in 3.2928 HRD-in -66.84, -51.14 79.92, -9.54 in-in-in SNCiii in-in ActLoopNT-in 2.8541 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.42, 150.12 APE9-dihe-na 136.94, -172.18 APE8-dihe-in -106.38, 111.25 APE8-rot-in 311.69 APE67-dihe-in -67.35, -18.0 -44.33, -42.84 APE12-dist-in 10.1791 APE11-dist-in 11.8759 APE10-dist-in 6.4163 APE9-dist-in 4.057 None TPO345,SEP346 TPO345,SEP346 XRAY 2.22 0.215 0.225 A 301.0 279.0 16 30 23 7 [[183, 456]] 1.0 5k72 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5K72C Q9NWZ3 164 458 460.0 6QY:501 Type1 Active DFGin 6.8592 14.8448 BLAminus -130.1, 165.54 64.05, 88.04 -103.72, 18.66 308.67, 101.27 -64.81, -28.57 in-in in 9.1235 Saltbr-in 3.0215 HRD-in -67.68, -49.88 78.27, -10.5 in-in-in SNCiii in-in ActLoopNT-in 2.8443 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.88, 146.9 APE9-dihe-na 138.11, -173.71 APE8-dihe-in -107.12, 113.22 APE8-rot-in 310.36 APE67-dihe-in -67.72, -16.57 -43.16, -46.42 APE12-dist-in 10.0365 APE11-dist-in 11.8165 APE10-dist-in 6.3526 APE9-dist-in 4.0558 None TPO345,SEP346 TPO345,SEP346 XRAY 2.22 0.215 0.225 C 301.0 279.0 16 30 23 7 [[183, 456]] 1.0 5k72 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5K72D Q9NWZ3 164 458 460.0 6QY:501 Type1 Active DFGin 6.8499 14.806 BLAminus -126.68, 172.94 63.42, 86.83 -103.81, 18.76 308.64, 101.29 -64.45, -29.98 in-in in 9.1769 Saltbr-in 3.1013 HRD-in -66.74, -50.47 78.85, -9.74 in-in-in SNCiii in-in ActLoopNT-in 2.8486 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.97, 148.93 APE9-dihe-na 136.71, -173.44 APE8-dihe-in -107.04, 113.0 APE8-rot-in 309.77 APE67-dihe-in -66.49, -17.75 -42.69, -46.95 APE12-dist-in 10.1232 APE11-dist-in 11.894 APE10-dist-in 6.3939 APE9-dist-in 3.9898 None TPO345,SEP346 TPO345,SEP346 XRAY 2.22 0.215 0.225 D 301.0 278.0 17 30 23 7 [[183, 456]] 1.0 5k72 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5K75A Q9NWZ3 164 458 460.0 6QX:501 Type1 Active DFGin 6.9609 14.4664 BLAminus -129.66, 172.88 64.37, 85.54 -104.02, 19.65 309.39, 101.24 -65.12, -32.34 in-in in 8.9961 Saltbr-in 3.3638 HRD-in -66.74, -50.79 80.27, -9.49 in-in-in SNCiii in-in ActLoopNT-in 2.8428 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.74, 147.16 APE9-dihe-na 138.19, -172.64 APE8-dihe-in -106.01, 110.67 APE8-rot-in 312.95 APE67-dihe-in -63.15, -20.46 -40.66, -48.43 APE12-dist-in 10.1694 APE11-dist-in 11.8969 APE10-dist-in 6.4602 APE9-dist-in 4.0576 None TPO345,SEP346 TPO345,SEP346 XRAY 2.03 0.24 0.253 A 301.0 273.0 22 30 22 8 [[183, 456]] 1.0 5k75 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5K76B Q9NWZ3 164 458 460.0 6R1:501 Type1 Active DFGin 6.842 14.8465 BLAminus -120.86, 179.92 54.63, 86.6 -104.85, 21.84 304.89, 98.02 -65.03, -33.77 in-in in 8.8208 Saltbr-in 3.3542 HRD-in -64.93, -47.01 74.5, -8.88 in-in-in SNCiii in-in ActLoopNT-in 2.797 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.39, 155.1 APE9-dihe-na 131.16, -171.05 APE8-dihe-in -106.73, 112.96 APE8-rot-in 313.37 APE67-dihe-in -69.81, -11.83 -40.26, -47.81 APE12-dist-in 10.0469 APE11-dist-in 11.658 APE10-dist-in 6.1477 APE9-dist-in 3.681 None TPO345,SEP346 TPO345,SEP346 XRAY 2.74 0.218 0.246 B 301.0 283.0 12 30 23 7 [[183, 456]] 1.0 5k76 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5K7GA Q9NWZ3 164 458 460.0 6R0:503 Type1 Active DFGin 6.9273 14.5789 BLAminus -130.44, 172.6 63.09, 86.67 -104.49, 18.83 308.78, 101.81 -65.52, -32.04 in-in in 8.8776 Saltbr-in 3.3007 HRD-in -67.24, -50.39 78.51, -10.38 in-in-in SNCiii in-in ActLoopNT-in 2.8499 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.81, 145.66 APE9-dihe-na 138.88, -174.27 APE8-dihe-in -106.05, 110.69 APE8-rot-in 312.32 APE67-dihe-in -63.78, -20.0 -39.72, -49.62 APE12-dist-in 10.0827 APE11-dist-in 11.8705 APE10-dist-in 6.4292 APE9-dist-in 4.12 None TPO345,SEP346 TPO345,SEP346 XRAY 2.23 0.207 0.227 A 301.0 279.0 16 30 23 7 [[183, 456]] 1.0 5k7g Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5K7GC Q9NWZ3 164 458 460.0 6R0:501 Type1 Active DFGin 6.9575 14.4653 BLAminus -132.74, 161.94 65.76, 88.06 -104.31, 18.89 309.03, 102.17 -65.27, -31.9 in-in in 8.8581 Saltbr-in 2.8923 HRD-in -66.94, -50.37 77.56, -9.09 in-in-in SNCiii in-in ActLoopNT-in 2.8541 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.84, 146.49 APE9-dihe-na 138.07, -172.84 APE8-dihe-in -106.43, 110.54 APE8-rot-in 312.48 APE67-dihe-in -63.68, -20.75 -40.38, -49.26 APE12-dist-in 10.1719 APE11-dist-in 11.746 APE10-dist-in 6.3479 APE9-dist-in 4.1262 None TPO345,SEP346 TPO345,SEP346 XRAY 2.23 0.207 0.227 C 301.0 285.0 10 30 23 7 [[183, 456]] 1.0 5k7g Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5K7GD Q9NWZ3 164 458 460.0 6R0:502 Type1 Active DFGin 6.9139 14.4521 BLAminus -130.04, 170.31 63.99, 86.8 -104.75, 18.86 309.06, 102.0 -64.76, -32.56 in-in in 8.818 Saltbr-in 3.1217 HRD-in -66.7, -50.93 78.39, -9.43 in-in-in SNCiii in-in ActLoopNT-in 2.8521 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.67, 145.96 APE9-dihe-na 138.88, -173.03 APE8-dihe-in -106.21, 110.06 APE8-rot-in 312.19 APE67-dihe-in -64.22, -19.64 -40.02, -49.24 APE12-dist-in 10.0286 APE11-dist-in 11.7906 APE10-dist-in 6.3793 APE9-dist-in 4.1312 None TPO345,SEP346 TPO345,SEP346 XRAY 2.23 0.207 0.227 D 301.0 285.0 10 30 23 7 [[183, 456]] 1.0 5k7g Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5K7IA Q9NWZ3 164 458 460.0 6QZ:501 Type1 Active DFGin 6.8482 14.706 BLAminus -122.1, 174.72 61.52, 86.0 -106.72, 22.05 309.28, 97.65 -66.92, -32.98 in-in in 8.6948 Saltbr-in 3.1305 HRD-in -68.39, -48.54 78.53, -8.67 in-in-in SNCiii in-in ActLoopNT-in 2.8118 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.35, 153.63 APE9-dihe-na 131.32, 179.82 APE8-dihe-in -93.7, 123.26 APE8-rot-in 312.64 APE67-dihe-in -64.14, -19.99 -53.75, -46.67 APE12-dist-in 10.1861 APE11-dist-in 11.8474 APE10-dist-in 6.4429 APE9-dist-in 4.0857 None TPO345,SEP346 TPO345,SEP346 XRAY 2.31 0.221 0.257 A 301.0 274.0 21 30 23 7 [[183, 456]] 1.0 5k7i Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5K7IB Q9NWZ3 164 458 460.0 6QZ:502 Type1 Active DFGin 6.8645 14.5179 BLAminus -124.19, 174.89 61.8, 86.03 -106.67, 22.39 309.0, 97.79 -67.01, -31.74 in-in in 8.7394 Saltbr-in 2.7998 HRD-in -68.08, -49.13 78.29, -7.61 in-in-in SNCiii in-in ActLoopNT-in 2.806 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.12, 153.82 APE9-dihe-na 132.9, -179.87 APE8-dihe-in -93.91, 123.35 APE8-rot-in 313.14 APE67-dihe-in -65.54, -19.28 -54.52, -46.07 APE12-dist-in 10.1598 APE11-dist-in 11.6579 APE10-dist-in 6.3434 APE9-dist-in 4.1334 None TPO345,SEP346 TPO345,SEP346 XRAY 2.31 0.221 0.257 B 301.0 273.0 22 30 23 7 [[183, 456]] 1.0 5k7i Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5KX7B Q9NWZ3 163 459 460.0 6YD:9901 Type1 Active DFGin 6.8554 13.2518 BLAminus -138.07, 174.73 58.64, 80.86 -106.82, 34.07 322.11, 87.79 -71.78, -44.9 in-in in 8.6821 Saltbr-in 3.2371 HRD-in -69.76, -47.63 72.83, 1.05 in-in-in SNCiii in-in ActLoopNT-in 2.7592 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.02, 154.26 APE9-dihe-na 136.96, -175.89 APE8-dihe-in -105.94, 108.82 APE8-rot-in 305.34 APE67-dihe-in -58.95, -17.61 -32.77, -53.96 APE12-dist-in 9.941 APE11-dist-in 11.4956 APE10-dist-in 6.1747 APE9-dist-in 3.7173 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.8 0.213 0.25 B 301.0 289.0 8 30 26 4 [[183, 456]] 1.0 5kx7 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5KX8A Q9NWZ3 163 459 460.0 6YE:501 Type1 Active DFGin 6.7791 13.4576 BLAminus -136.36, -178.34 58.1, 85.73 -110.83, 15.69 315.13, 102.91 -62.12, -34.73 in-in in 8.5225 Saltbr-in 3.3223 HRD-in -62.27, -51.5 76.44, -1.78 in-in-in SNCiii in-in ActLoopNT-in 2.6572 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.83, 147.8 APE9-dihe-na 142.35, -171.73 APE8-dihe-in -109.78, 108.72 APE8-rot-in 309.05 APE67-dihe-in -63.27, -20.61 -34.23, -50.93 APE12-dist-in 9.9822 APE11-dist-in 11.7043 APE10-dist-in 6.474 APE9-dist-in 3.9523 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.671 0.206 0.233 A 301.0 288.0 9 30 26 4 [[183, 456]] 1.0 5kx8 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5KX8B Q9NWZ3 161 459 460.0 6YE:501 Type1 Active DFGin 6.8282 13.5255 BLAminus -135.84, -178.32 58.25, 85.42 -111.0, 16.47 315.08, 103.62 -62.58, -35.26 in-in in 8.5718 Saltbr-in 2.7685 HRD-in -60.81, -51.76 76.06, -1.89 in-in-in SNCiii in-in ActLoopNT-in 2.9656 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.8, 147.8 APE9-dihe-na 142.56, -171.32 APE8-dihe-in -109.67, 108.54 APE8-rot-in 308.6 APE67-dihe-in -62.57, -21.11 -33.86, -51.07 APE12-dist-in 9.7078 APE11-dist-in 11.7045 APE10-dist-in 6.4667 APE9-dist-in 3.945 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.671 0.206 0.233 B 301.0 281.0 18 30 24 6 [[183, 456]] 1.0 5kx8 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5KX8D Q9NWZ3 164 459 460.0 6YE:501 Type1 Active DFGin 6.8858 13.4854 BLAminus -135.91, -178.68 58.98, 85.41 -110.88, 16.35 315.61, 103.98 -63.33, -34.97 in-in in 8.1882 Saltbr-in 3.2202 HRD-in -64.45, -52.27 77.75, -2.01 in-in-in SNCiii in-in ActLoopNT-in 2.6653 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.53, 147.84 APE9-dihe-na 141.85, -171.68 APE8-dihe-in -109.93, 107.97 APE8-rot-in 309.23 APE67-dihe-in -62.28, -20.43 -33.87, -50.84 APE12-dist-in 10.0055 APE11-dist-in 11.708 APE10-dist-in 6.4759 APE9-dist-in 3.9673 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.671 0.206 0.233 D 301.0 286.0 10 30 25 5 [[183, 456]] 1.0 5kx8 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5T1SD Q9NWZ3 164 459 460.0 76Q:9901 Type1 Active DFGin 6.951 14.2485 BLAminus -130.82, 172.71 63.6, 85.49 -103.7, 19.85 304.96, 98.34 -62.88, -38.58 in-in in 8.7924 Saltbr-in 3.1253 HRD-in -67.81, -51.47 79.11, -4.9 in-in-in SNCiii in-in ActLoopNT-in 2.7702 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.3, 155.38 APE9-dihe-na 137.43, -168.44 APE8-dihe-in -112.84, 114.02 APE8-rot-in 311.54 APE67-dihe-in -62.52, -17.13 -40.93, -51.81 APE12-dist-in 9.9302 APE11-dist-in 11.6365 APE10-dist-in 6.235 APE9-dist-in 3.7867 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.207 0.223 D 301.0 284.0 12 30 25 5 [[183, 456]] 1.0 5t1s Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4Y73D Q9NWZ3 164 459 460.0 XPY:1000 Type1 Active DFGin 6.9462 13.9421 BLAminus -134.48, 179.63 58.03, 76.69 -96.29, 18.79 309.44, 97.62 -57.19, -32.63 in-in in 8.8874 Saltbr-in 3.1833 HRD-in -69.87, -49.37 75.0, -4.9 in-in-in SNCiii in-in ActLoopNT-in 2.7499 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.55, 154.63 APE9-dihe-na 135.98, -173.49 APE8-dihe-in -109.02, 111.96 APE8-rot-in 310.2 APE67-dihe-in -59.31, -19.91 -40.37, -53.91 APE12-dist-in 10.0238 APE11-dist-in 11.7099 APE10-dist-in 6.3725 APE9-dist-in 4.0774 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.14 0.196 0.217 D 302.0 291.0 5 30 25 5 [[183, 456]] 1.0 4y73 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6MOMA Q9NWZ3 164 460 460.0 JX4:500 Type1 Active DFGin 7.1288 13.3417 BLAminus -133.95, 172.65 70.74, 82.36 -107.03, 19.92 305.8, 92.98 -64.41, -27.6 in-in in 8.2554 Saltbr-in 3.009 HRD-in -79.36, -51.43 75.47, 2.41 in-in-in SNCiii in-in ActLoopNT-in 2.7127 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.06, 152.26 APE9-dihe-na 137.43, -179.57 APE8-dihe-in -101.68, 120.01 APE8-rot-in 303.6 APE67-dihe-in -63.77, -14.43 -53.86, -42.85 APE12-dist-in 10.3433 APE11-dist-in 12.1388 APE10-dist-in 7.3018 APE9-dist-in 4.7914 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.168 0.207 A 303.0 289.0 8 30 27 3 [[183, 456]] 1.0 6mom Homo sapiens TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6MOMC Q9NWZ3 163 460 460.0 JX4:500 Type1 Active DFGin 7.1322 13.3299 BLAminus -133.27, 172.2 69.98, 81.72 -106.08, 16.49 303.99, 96.21 -63.79, -25.79 in-in in 8.2366 Saltbr-in 2.78 HRD-in -77.9, -50.77 76.54, 1.38 in-in-in SNCiii in-in ActLoopNT-in 2.7171 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.08, 151.25 APE9-dihe-na 135.21, -179.82 APE8-dihe-in -101.82, 118.78 APE8-rot-in 306.47 APE67-dihe-in -63.2, -15.41 -53.95, -41.15 APE12-dist-in 10.3567 APE11-dist-in 12.0705 APE10-dist-in 7.0672 APE9-dist-in 4.647 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.168 0.207 C 303.0 292.0 6 30 27 3 [[183, 456]] 1.0 6mom Homo sapiens TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 9NA3A Q9NWZ3 164 458 460.0 A1BWX:501 Type1 Active DFGin 6.752 13.8599 BLAminus -133.1, 172.88 66.49, 85.44 -111.24, 22.95 310.94, 83.55 -69.24, -28.75 in-in in 8.6045 Saltbr-in 3.0051 HRD-in -73.29, -51.42 75.45, 6.3 in-in-in SNCiii in-in ActLoopNT-in 2.9071 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.49, 152.01 APE9-dihe-na 139.45, -179.34 APE8-dihe-in -101.95, 112.38 APE8-rot-in 313.22 APE67-dihe-in -64.69, -17.61 -61.03, -33.08 APE12-dist-in 9.927 APE11-dist-in 11.7302 APE10-dist-in 6.4552 APE9-dist-in 4.2549 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.245 0.277 A 304.0 284.0 11 30 25 5 [[183, 456]] 1.0 9na3 Homo sapiens TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 9NA3H0A0 Q9NWZ3 164 459 460.0 A1BWX:501 Type1 Active DFGin 6.5887 14.4287 BLAminus -128.39, 175.47 61.09, 89.59 -111.86, 22.39 307.69, 91.01 -72.62, -22.45 in-in in 9.0451 Saltbr-in 3.1983 HRD-in -69.35, -50.66 74.83, 1.0 in-in-in SNCiii in-in ActLoopNT-in 2.7258 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.08, 148.29 APE9-dihe-na 138.75, -172.51 APE8-dihe-in -111.34, 119.79 APE8-rot-in 307.77 APE67-dihe-in -65.4, -14.21 -55.78, -41.76 APE12-dist-in 9.9985 APE11-dist-in 11.593 APE10-dist-in 6.0692 APE9-dist-in 4.0699 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.245 0.277 H0A0 304.0 277.0 19 30 25 5 [[183, 456]] 1.0 9na3 Homo sapiens TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 9NA4A Q9NWZ3 164 459 460.0 A1BW1:501 Type1 Active DFGin 6.8128 14.3101 BLAminus -127.38, -174.41 53.31, 76.49 -96.02, 23.68 303.26, 85.02 -73.65, -19.1 in-in in 8.8284 Saltbr-in 2.8811 HRD-in -71.63, -47.62 74.26, 11.21 in-in-in SNCiii in-in ActLoopNT-in 2.7297 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.51, 136.05 APE9-dihe-na 160.84, -170.21 APE8-dihe-in -108.63, 109.57 APE8-rot-in 307.2 APE67-dihe-in -69.94, -9.11 -50.47, -38.9 APE12-dist-in 9.7732 APE11-dist-in 11.7326 APE10-dist-in 6.7006 APE9-dist-in 4.1292 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.33 0.227 0.273 A 304.0 283.0 13 30 25 5 [[183, 456]] 1.0 9na4 Homo sapiens TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 9NA4B Q9NWZ3 164 459 460.0 A1BW1:501 Type1 Active DFGin 6.8953 14.2573 BLAminus -128.47, -178.23 58.06, 81.63 -102.84, 25.74 297.67, 81.88 -71.22, -28.21 in-in in 8.905 Saltbr-in 3.1288 HRD-in -72.71, -43.84 74.71, -2.67 in-in-in SNCiii in-in ActLoopNT-in 2.7416 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.53, 162.66 APE9-dihe-na 130.06, -172.53 APE8-dihe-in -106.79, 115.27 APE8-rot-in 294.12 APE67-dihe-in -66.46, -17.91 -59.45, -33.75 APE12-dist-in 9.8798 APE11-dist-in 11.3984 APE10-dist-in 6.504 APE9-dist-in 4.2936 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.33 0.227 0.273 B 304.0 283.0 13 30 25 5 [[183, 456]] 1.0 9na4 Homo sapiens TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 9NA4C Q9NWZ3 164 459 460.0 A1BW1:501 Type1 Active DFGin 6.8619 13.9119 BLAminus -133.2, 178.13 56.03, 83.33 -103.05, 20.53 303.74, 87.67 -66.4, -20.44 in-in in 8.9563 Saltbr-in 2.982 HRD-in -79.23, -52.87 78.53, 5.04 in-in-in SNCiii in-in ActLoopNT-in 2.7295 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.71, 151.98 APE9-dihe-na 136.82, -178.5 APE8-dihe-in -102.72, 112.21 APE8-rot-in 308.82 APE67-dihe-in -65.51, -14.62 -58.09, -34.11 APE12-dist-in 10.1177 APE11-dist-in 11.7744 APE10-dist-in 6.7322 APE9-dist-in 4.3722 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.33 0.227 0.273 C 304.0 285.0 11 30 25 5 [[183, 456]] 1.0 9na4 Homo sapiens TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 9NA4D Q9NWZ3 165 459 460.0 A1BW1:501 Type1 Active DFGin 6.9821 14.1652 BLAminus -128.79, -176.45 53.3, 89.86 -110.92, 19.74 296.14, 90.51 -74.91, -26.5 in-in in 8.9318 Saltbr-in 2.6587 HRD-in -78.81, -47.02 77.11, -5.8 in-in-in SNCiii in-in ActLoopNT-in 2.7715 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.58, 166.79 APE9-dihe-na 117.7, -160.99 APE8-dihe-in -116.5, 117.73 APE8-rot-in 325.76 APE67-dihe-in -62.89, -19.72 -54.11, -37.62 APE12-dist-in 10.066 APE11-dist-in 11.5289 APE10-dist-in 6.5058 APE9-dist-in 4.3708 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.33 0.227 0.273 D 304.0 284.0 11 30 25 5 [[183, 456]] 1.0 9na4 Homo sapiens TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5W84A Q9NWZ3 165 459 460.0 9YY:4000 Type1 Active DFGin 7.2908 14.7392 BLAminus -116.66, -177.09 50.05, 80.29 -103.22, 13.06 304.5, 91.12 -69.66, -13.48 in-in in 8.6947 Saltbr-in 3.1553 HRD-in -58.29, -49.11 72.64, 6.83 in-in-in SNCiii in-in ActLoopNT-in 2.7779 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.65, 156.49 APE9-dihe-na 134.34, -164.03 APE8-dihe-in -112.68, 108.44 APE8-rot-in 309.9 APE67-dihe-inflip 85.12, -33.46 -56.68, 166.21 APE12-dist-in 10.3832 APE11-dist-in 11.9942 APE10-dist-in 6.7579 APE9-dist-in 3.6777 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.9 0.202 0.248 A 305.0 282.0 13 30 25 5 [[183, 456]] 1.0 5w84 Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8SCEB Q9NWZ3 164 458 460.0 ZVD:501 Type1 Active DFGin 6.8725 13.8448 BLAminus -128.59, -178.77 60.92, 81.27 -102.45, 15.1 307.63, 100.59 -60.68, -32.26 in-in in 8.6415 Saltbr-in 3.2068 HRD-in -69.44, -52.46 77.81, -3.32 in-in-in SNCiii in-in ActLoopNT-in 2.7901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.77, 152.58 APE9-dihe-na 139.09, -170.98 APE8-dihe-in -109.95, 109.6 APE8-rot-in 309.72 APE67-dihe-in -61.76, -17.48 -53.14, -40.37 APE12-dist-in 10.5158 APE11-dist-in 11.7603 APE10-dist-in 6.561 APE9-dist-in 4.2252 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.89 0.204 0.228 B 305.0 287.0 8 30 25 5 [[183, 456]] 1.0 8sce Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8SCED Q9NWZ3 161 459 460.0 ZVD:502 Type1 Active DFGin 6.7762 13.9041 BLAminus -121.43, -179.64 62.94, 81.94 -102.76, 13.61 305.86, 101.34 -60.3, -31.77 in-in in 8.6314 Saltbr-in 3.283 HRD-in -70.01, -51.91 77.74, -5.02 in-in-in SNCiii in-in ActLoopNT-in 2.7748 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.26, 152.99 APE9-dihe-na 137.91, -170.79 APE8-dihe-in -110.55, 110.46 APE8-rot-in 310.04 APE67-dihe-in -60.43, -17.98 -47.93, -46.75 APE12-dist-in 10.4381 APE11-dist-in 11.9081 APE10-dist-in 6.6649 APE9-dist-in 4.244 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.89 0.204 0.228 D 305.0 289.0 10 30 26 4 [[183, 456]] 1.0 8sce Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8SCEE Q9NWZ3 162 459 460.0 ZVD:503 Type1 Active DFGin 6.8879 13.9235 BLAminus -126.97, -179.73 60.71, 81.73 -102.64, 14.04 307.26, 101.4 -57.91, -39.49 in-in in 8.6754 Saltbr-in 3.5345 HRD-in -70.01, -51.05 77.24, -5.5 in-in-in SNCiii in-in ActLoopNT-in 2.7794 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.13, 152.08 APE9-dihe-na 138.21, -170.74 APE8-dihe-in -110.91, 109.01 APE8-rot-in 310.79 APE67-dihe-in -61.86, -16.65 -47.33, -46.49 APE12-dist-in 10.5153 APE11-dist-in 11.9011 APE10-dist-in 6.6318 APE9-dist-in 4.2245 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.89 0.204 0.228 E 305.0 285.0 13 30 26 4 [[183, 456]] 1.0 8sce Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8SCVA Q9NWZ3 163 458 460.0 ZVG:501 Type1 Active DFGin 7.184 13.9863 BLAminus -124.46, -179.76 59.49, 87.11 -109.26, 17.19 305.43, 95.33 -61.37, -28.15 in-in in 8.6029 Saltbr-in 2.786 HRD-in -70.57, -45.98 74.49, -10.35 in-in-in SNCiii in-in ActLoopNT-in 2.7225 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.75, 138.68 APE9-dihe-na 145.66, -163.91 APE8-dihe-in -109.56, 109.15 APE8-rot-in 316.1 APE67-dihe-in -55.77, -25.63 -52.88, -41.01 APE12-dist-in 11.5674 APE11-dist-in 11.7092 APE10-dist-in 6.5021 APE9-dist-in 4.3107 None SEP284,TPO345,SEP346 SEP284,TPO345,SEP346 XRAY 2.69 0.222 0.261 A 305.0 290.0 6 30 26 4 [[183, 456]] 1.0 8scv Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8SCWA Q9NWZ3 164 458 460.0 ZVA:502 Type1 Active DFGin 6.949 13.9554 BLAminus -127.98, -178.64 58.18, 81.05 -102.57, 16.55 304.99, 101.16 -62.35, -27.98 in-in in 8.6228 Saltbr-in 3.0695 HRD-in -64.77, -51.29 78.36, -5.77 in-in-in SNCiii in-in ActLoopNT-in 2.783 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.58, 147.29 APE9-dihe-na 136.17, -170.2 APE8-dihe-in -107.72, 107.21 APE8-rot-in 307.44 APE67-dihe-in -62.81, -21.07 -41.99, -38.76 APE12-dist-in 10.2887 APE11-dist-in 11.803 APE10-dist-in 6.5358 APE9-dist-in 4.1925 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.76 0.197 0.238 A 305.0 286.0 9 30 25 5 [[183, 456]] 1.0 8scw Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8SCWB Q9NWZ3 164 458 460.0 ZVA:503 Type1 Active DFGin 6.9168 13.9346 BLAminus -128.2, -178.62 57.88, 81.14 -102.7, 16.27 305.4, 99.65 -62.0, -27.36 in-in in 8.6796 Saltbr-in 3.1049 HRD-in -66.25, -47.62 74.19, -3.24 in-in-in SNCiii in-in ActLoopNT-in 2.8495 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.99, 148.79 APE9-dihe-na 138.79, -168.97 APE8-dihe-in -106.05, 107.42 APE8-rot-in 307.69 APE67-dihe-in -61.91, -21.89 -43.06, -38.9 APE12-dist-in 10.1493 APE11-dist-in 11.6777 APE10-dist-in 6.4467 APE9-dist-in 4.1736 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.76 0.197 0.238 B 305.0 286.0 9 30 25 5 [[183, 456]] 1.0 8scw Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8SCWC Q9NWZ3 164 458 460.0 ZVA:504 Type1 Active DFGin 6.9904 13.9574 BLAminus -128.34, -178.84 58.46, 80.95 -102.7, 17.0 305.11, 100.34 -60.28, -38.49 in-in in 8.6123 Saltbr-in 3.0779 HRD-in -64.94, -50.47 78.38, -7.14 in-in-in SNCiii in-in ActLoopNT-in 2.7877 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.26, 147.61 APE9-dihe-na 135.64, -170.98 APE8-dihe-in -106.84, 106.55 APE8-rot-in 307.9 APE67-dihe-in -62.95, -20.83 -41.66, -39.27 APE12-dist-in 10.2813 APE11-dist-in 11.9023 APE10-dist-in 6.5798 APE9-dist-in 4.1563 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.76 0.197 0.238 C 305.0 284.0 11 30 24 6 [[183, 456]] 1.0 8scw Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8SCWD Q9NWZ3 164 458 460.0 ZVA:503 Type1 Active DFGin 6.9301 13.9264 BLAminus -127.14, -178.48 58.45, 80.61 -102.69, 16.54 304.74, 100.68 -62.23, -29.15 in-in in 8.5743 Saltbr-in 3.051 HRD-in -64.31, -51.28 79.3, -9.6 in-in-in SNCiii in-in ActLoopNT-in 2.7763 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.27, 148.51 APE9-dihe-na 135.19, -171.01 APE8-dihe-in -107.16, 107.03 APE8-rot-in 307.56 APE67-dihe-in -62.12, -22.03 -41.61, -38.47 APE12-dist-in 10.2513 APE11-dist-in 11.8888 APE10-dist-in 6.5736 APE9-dist-in 4.1593 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.76 0.197 0.238 D 305.0 284.0 11 30 24 6 [[183, 456]] 1.0 8scw Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 2NRYC Q9NWZ3 164 458 460.0 STU:503 Type1 Active DFGin 7.3959 13.9911 BLAminus -129.87, 177.33 66.53, 79.75 -106.36, 3.08 302.75, 99.86 -41.96, -44.4 in-in in 9.0503 Saltbr-in 2.876 HRD-in -69.99, -46.9 74.7, -3.92 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.06, 166.37 APE9-dihe-na 122.8, -162.09 APE8-dihe-in -122.72, 120.05 APE8-rot-in 297.38 APE67-dihe-in -61.23, -20.14 -50.62, -47.6 APE12-dist-in 11.8451 APE11-dist-in 12.224 APE10-dist-in 6.9995 APE9-dist-in 3.8635 None TPO345 TPO345 XRAY 2.15 0.212 0.261 C 307.0 281.0 14 30 26 4 [[183, 456]] 1.0 2nry Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 2NRYD Q9NWZ3 164 460 460.0 STU:501 Type1 Active DFGin 7.1034 14.6012 BLAminus -126.69, 167.35 70.82, 64.69 -93.05, 43.05 345.42, 126.85 -89.85, -18.2 in-in in 9.1762 Saltbr-in 2.9498 HRD-in -59.6, -55.9 83.92, -5.49 in-in-in SNCiii in-in ActLoopNT-in 2.7235 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.15, 176.95 APE9-dihe-na 112.24, -167.34 APE8-dihe-in -128.61, 119.15 APE8-rot-in 302.8 APE67-dihe-in -66.3, -17.75 -48.9, -47.71 APE12-dist-in 10.0254 APE11-dist-in 11.6148 APE10-dist-in 6.2715 APE9-dist-in 3.5382 None TPO345 TPO345 XRAY 2.15 0.212 0.261 D 307.0 283.0 14 30 25 5 [[183, 456]] 1.0 2nry Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8TVMB Q9NWZ3 164 459 460.0 VDC:501 Type1 Active DFGin 6.7569 13.5478 BLAminus -140.59, 174.72 61.77, 69.23 -90.22, 25.09 318.9, 80.9 -70.23, -27.26 in-in in 8.9524 Saltbr-in 3.5122 HRD-in -71.78, -55.46 78.6, -2.38 in-in-in SNCiii in-in ActLoopNT-in 2.898 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.68, 151.46 APE9-dihe-na 150.0, -172.63 APE8-dihe-in -105.17, 113.19 APE8-rot-in 324.78 APE67-dihe-in -64.51, -17.83 -60.0, -33.31 APE12-dist-in 10.1836 APE11-dist-in 11.6186 APE10-dist-in 6.722 APE9-dist-in 4.1456 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.223 0.246 B 307.0 289.0 7 30 25 5 [[183, 456]] 1.0 8tvm Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8TVNA Q9NWZ3 167 459 460.0 VE9:501 Type1 Active DFGin 6.8013 14.5814 BLAminus -129.9, -179.17 62.87, 70.82 -90.97, 13.68 296.57, 88.9 -64.15, -18.87 in-in in 8.9586 Saltbr-in 3.5257 HRD-in -70.68, -50.01 73.53, -1.21 in-in-in SNCiii in-in ActLoopNT-in 2.8215 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.33, 162.7 APE9-dihe-na 136.65, 178.35 APE8-dihe-in -105.63, 112.36 APE8-rot-in 304.38 APE67-dihe-in -66.2, -13.47 -50.45, -42.66 APE12-dist-in 10.2672 APE11-dist-in 11.4969 APE10-dist-in 6.0672 APE9-dist-in 3.5946 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.95 0.208 0.242 A 307.0 282.0 11 30 24 6 [[183, 456]] 1.0 8tvn Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6THXA Q9NWZ3 164 458 460.0 N9Z:501 Type1 Active DFGin 6.5269 14.5293 BLAminus -127.56, 172.71 65.6, 83.21 -103.86, 30.76 312.6, 124.02 -71.9, -39.12 in-in in 8.4488 Saltbr-in 3.1272 HRD-in -68.51, -52.67 79.87, -7.09 in-in-in SNCiii in-in ActLoopNT-in 2.7729 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.98, 146.03 APE9-dihe-na 147.06, -173.06 APE8-dihe-in -104.96, 109.73 APE8-rot-in 309.29 APE67-dihe-in -62.88, -17.94 -53.78, -36.75 APE12-dist-in 10.1457 APE11-dist-in 11.8181 APE10-dist-in 6.4566 APE9-dist-in 4.0718 None TPO345,SEP346 TPO345,SEP346 XRAY 1.99 0.232 0.254 A 308.0 279.0 16 30 24 6 [[183, 456]] 1.0 6thx Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6THZA Q9NWZ3 165 458 460.0 NB5:501 Type1 Active DFGin 7.0352 14.6174 BLAminus -132.59, 174.22 64.51, 87.68 -105.41, 12.97 302.18, 105.06 -60.16, -39.11 in-in in 8.7311 Saltbr-in 3.5149 HRD-in -71.52, -47.24 73.49, 0.54 in-in-in SNCiii in-in ActLoopNT-in 2.7941 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.0, 149.74 APE9-dihe-na 142.66, -166.48 APE8-dihe-in -108.46, 106.97 APE8-rot-in 312.32 APE67-dihe-in -65.37, -19.1 -35.78, -49.68 APE12-dist-in 10.562 APE11-dist-in 12.0194 APE10-dist-in 6.8127 APE9-dist-in 4.1097 None TPO345,SEP346 TPO345,SEP346 XRAY 2.38 0.233 0.274 A 308.0 267.0 27 30 24 6 [[183, 456]] 1.0 6thz Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6TI8A Q9NWZ3 165 459 460.0 NBW:501 Type1 Active DFGin 6.4958 14.6874 BLAminus -132.22, 174.78 65.5, 84.55 -108.45, 28.29 312.44, 86.03 -64.97, -26.16 in-in in 8.3272 Saltbr-in 3.3681 HRD-in -64.49, -50.7 73.68, -1.41 in-in-in SNCiii in-in ActLoopNT-in 2.811 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.02, 143.49 APE9-dihe-na 153.75, -168.62 APE8-dihe-in -108.33, 109.09 APE8-rot-in 310.4 APE67-dihe-in -69.46, -9.13 -46.33, -44.33 APE12-dist-in 10.5795 APE11-dist-in 11.6962 APE10-dist-in 6.6386 APE9-dist-in 4.027 None TPO345,SEP346 TPO345,SEP346 XRAY 2.32 0.25 0.281 A 308.0 284.0 11 30 24 6 [[183, 456]] 1.0 6ti8 Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6TI8B Q9NWZ3 165 459 460.0 NBW:501 Type1 Active DFGin 6.8303 14.8598 BLAminus -122.99, 177.68 58.9, 84.31 -102.33, 16.41 302.19, 94.44 -63.27, -32.27 in-in in 8.5736 Saltbr-in 2.9774 HRD-in -64.71, -50.68 74.15, -2.22 in-in-in SNCiii in-in ActLoopNT-in 2.8108 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.3, 142.5 APE9-dihe-na 153.81, -169.31 APE8-dihe-in -108.96, 109.53 APE8-rot-in 310.52 APE67-dihe-in -69.44, -9.65 -46.25, -44.57 APE12-dist-in 10.5598 APE11-dist-in 11.7446 APE10-dist-in 6.6717 APE9-dist-in 4.0381 None TPO345,SEP346 TPO345,SEP346 XRAY 2.32 0.25 0.281 B 308.0 282.0 13 30 23 7 [[183, 456]] 1.0 6ti8 Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6TI8C Q9NWZ3 164 459 460.0 NBW:501 Type1 Active DFGin 6.6548 14.4556 BLAminus -124.84, 176.47 59.94, 83.94 -103.8, 22.42 311.19, 97.24 -66.26, -29.87 in-in in 8.6414 Saltbr-in 2.8322 HRD-in -65.72, -50.02 73.46, -0.5 in-in-in SNCiii in-in ActLoopNT-in 2.8056 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.4, 142.09 APE9-dihe-na 155.32, -168.59 APE8-dihe-in -109.34, 108.99 APE8-rot-in 310.65 APE67-dihe-in -68.15, -9.66 -46.14, -45.0 APE12-dist-in 10.5162 APE11-dist-in 11.6096 APE10-dist-in 6.577 APE9-dist-in 4.0295 None TPO345,SEP346 TPO345,SEP346 XRAY 2.32 0.25 0.281 C 308.0 285.0 11 30 23 7 [[183, 456]] 1.0 6ti8 Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6TI8D Q9NWZ3 164 458 460.0 NBW:501 Type1 Active DFGin 6.6646 14.2723 BLAminus -125.76, 177.59 59.54, 84.07 -104.02, 21.13 313.62, 95.57 -66.12, -29.76 in-in in 8.6145 Saltbr-in 3.0599 HRD-in -64.51, -50.99 73.54, -1.12 in-in-in SNCiii in-in ActLoopNT-in 2.803 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.51, 142.91 APE9-dihe-na 153.9, -168.19 APE8-dihe-in -108.74, 108.12 APE8-rot-in 312.3 APE67-dihe-in -68.08, -10.4 -45.75, -44.97 APE12-dist-in 10.5281 APE11-dist-in 11.6616 APE10-dist-in 6.6114 APE9-dist-in 4.0361 None TPO345,SEP346 TPO345,SEP346 XRAY 2.32 0.25 0.281 D 308.0 284.0 11 30 23 7 [[183, 456]] 1.0 6ti8 Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 7QG3A Q9NWZ3 164 458 460.0 B4U:501 Type1 Active DFGin 6.9181 15.1287 BLAminus -118.63, 175.18 58.47, 100.85 -117.38, 18.69 296.79, 96.31 -62.72, -22.67 in-in in 8.5187 Saltbr-in 2.81 HRD-in -67.79, -50.6 77.88, -8.47 in-in-in SNCiii in-in ActLoopNT-in 2.7837 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.78, 143.14 APE9-dihe-na 150.68, -166.83 APE8-dihe-in -109.63, 113.48 APE8-rot-in 315.93 APE67-dihe-in -63.55, -19.13 -55.1, -38.42 APE12-dist-in 10.8649 APE11-dist-in 11.7855 APE10-dist-in 6.7056 APE9-dist-in 4.2432 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.11 0.273 0.304 A 308.0 278.0 17 30 24 6 [[183, 456]] 1.0 7qg3 Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 9R9JA Q9NWZ3 161 458 460.0 A1JDR:501 Type1 Active DFGin 6.8659 14.3463 BLAminus -129.25, 179.93 58.23, 81.1 -101.74, 30.63 308.21, 100.29 -70.86, -33.46 in-in in 8.2604 Saltbr-in 2.7897 HRD-in -63.31, -48.65 74.54, -3.02 in-in-in SNCiii in-in ActLoopNT-in 2.7549 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.24, 156.68 APE9-dihe-na 136.68, -172.42 APE8-dihe-in -113.58, 112.35 APE8-rot-in 310.23 APE67-dihe-in -62.74, -18.52 -46.74, -43.52 APE12-dist-in 10.2203 APE11-dist-in 11.4894 APE10-dist-in 5.9896 APE9-dist-in 3.6231 None TPO345,SEP346 TPO345,SEP346 XRAY 2.39 0.223 0.263 A 308.0 286.0 12 30 26 4 [[183, 456]] 1.0 9r9j Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 9R9JB Q9NWZ3 161 458 460.0 A1JDR:501 Type1 Active DFGin 6.8465 14.6405 BLAminus -131.61, -178.04 51.54, 84.54 -96.41, 15.7 297.09, 102.18 -62.93, -32.93 in-in in 8.5012 Saltbr-in 2.6937 HRD-in -63.37, -52.47 76.18, 0.48 in-in-in SNCiii in-in ActLoopNT-in 2.8344 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.52, 156.28 APE9-dihe-na 136.33, -173.58 APE8-dihe-in -113.86, 111.72 APE8-rot-in 311.39 APE67-dihe-in -61.96, -19.34 -42.6, -47.27 APE12-dist-in 10.2039 APE11-dist-in 11.5149 APE10-dist-in 6.0235 APE9-dist-in 3.5595 None TPO345,SEP346 TPO345,SEP346 XRAY 2.39 0.223 0.263 B 308.0 288.0 10 30 26 4 [[183, 456]] 1.0 9r9j Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 9R9JC Q9NWZ3 164 458 460.0 A1JDR:501 Type1 Active DFGin 7.0778 14.5939 BLAminus -129.42, 175.26 60.25, 82.4 -97.97, 19.86 302.57, 101.34 -61.97, -34.27 in-in in 8.4059 Saltbr-in 2.7486 HRD-in -64.97, -49.19 74.55, -3.37 in-in-in SNCiii in-in ActLoopNT-in 2.8463 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.64, 156.94 APE9-dihe-na 136.07, -170.81 APE8-dihe-in -114.95, 112.8 APE8-rot-in 308.93 APE67-dihe-in -61.09, -18.92 -46.93, -44.09 APE12-dist-in 10.1321 APE11-dist-in 11.497 APE10-dist-in 6.0134 APE9-dist-in 3.654 None TPO345,SEP346 TPO345,SEP346 XRAY 2.39 0.223 0.263 C 308.0 286.0 9 30 26 4 [[183, 456]] 1.0 9r9j Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 9R9JD Q9NWZ3 164 458 460.0 A1JDR:501 Type1 Active DFGin 6.7491 14.2965 BLAminus -130.45, 174.51 61.25, 83.64 -101.39, 23.57 312.6, 100.72 -63.42, -32.89 in-in in 8.4166 Saltbr-in 2.754 HRD-in -65.01, -48.51 74.63, -4.34 in-in-in SNCiii in-in ActLoopNT-in 2.7552 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.48, 154.74 APE9-dihe-na 136.0, -172.13 APE8-dihe-in -115.41, 112.47 APE8-rot-in 309.74 APE67-dihe-in -62.04, -18.44 -44.31, -45.7 APE12-dist-in 10.3119 APE11-dist-in 11.6086 APE10-dist-in 6.0691 APE9-dist-in 3.6424 None TPO345,SEP346 TPO345,SEP346 XRAY 2.39 0.223 0.263 D 308.0 281.0 14 30 25 5 [[183, 456]] 1.0 9r9j Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 9R9KA Q9NWZ3 162 460 460.0 A1JDQ:501 Type1 Active DFGin 6.9262 14.0839 BLAminus -126.64, 177.21 56.19, 79.08 -95.18, 26.45 305.03, 89.52 -65.57, -28.51 in-in in 8.9061 Saltbr-in 3.1673 HRD-in -66.88, -49.66 78.32, -6.79 in-in-in SNCiii in-in ActLoopNT-in 2.8729 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.84, 161.94 APE9-dihe-na 133.27, -170.49 APE8-dihe-in -114.57, 114.37 APE8-rot-in 305.97 APE67-dihe-in -63.05, -13.23 -41.26, -51.52 APE12-dist-in 10.1327 APE11-dist-in 11.553 APE10-dist-in 6.1785 APE9-dist-in 3.6673 None TPO345,SEP346 TPO345,SEP346 XRAY 1.87 0.216 0.242 A 308.0 286.0 13 30 23 7 [[183, 456]] 1.0 9r9k Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 9R9KB Q9NWZ3 158 460 460.0 A1JDQ:501 Type1 Active DFGin 7.054 14.0094 BLAminus -121.37, 179.62 54.87, 78.76 -94.27, 23.12 304.61, 89.05 -66.48, -26.41 in-in in 9.139 Saltbr-in 3.5739 HRD-in -67.81, -49.8 79.17, -8.08 in-in-in SNCiii in-in ActLoopNT-in 2.8783 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.42, 161.33 APE9-dihe-na 132.97, -172.93 APE8-dihe-in -114.32, 113.72 APE8-rot-in 306.88 APE67-dihe-in -62.56, -13.28 -40.03, -52.35 APE12-dist-in 10.1603 APE11-dist-in 11.5171 APE10-dist-in 6.1401 APE9-dist-in 3.7276 None TPO345,SEP346 TPO345,SEP346 XRAY 1.87 0.216 0.242 B 308.0 290.0 13 30 23 7 [[183, 456]] 1.0 9r9k Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6O9DC Q9NWZ3 163 458 460.0 LTY:501 Type1 Active DFGin 6.9212 14.0549 BLAminus -144.04, 172.46 65.41, 89.1 -109.46, 16.79 309.79, 96.88 -60.57, -25.46 in-in in 8.6382 Saltbr-in 3.2434 HRD-in -67.13, -59.39 84.36, 2.8 in-in-in SNCiii in-in ActLoopNT-in 2.9172 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.08, 166.4 APE9-dihe-na 121.39, -170.65 APE8-dihe-in -111.39, 114.64 APE8-rot-in 323.79 APE67-dihe-in -65.1, -19.0 -57.03, -32.94 APE12-dist-in 10.0662 APE11-dist-in 11.8362 APE10-dist-in 6.5389 APE9-dist-in 4.0321 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.51 0.197 0.239 C 320.0 283.0 13 30 25 5 [[183, 456]] 1.0 6o9d Homo sapiens TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6UYAC Q9NWZ3 162 458 460.0 QL7:501 Type1 Active DFGin 6.469 14.031 BLAminus -122.12, 175.34 66.82, 92.98 -113.93, 10.94 305.64, 93.58 -60.94, -31.46 in-in in 8.6103 Saltbr-in 3.4686 HRD-in -67.21, -51.18 74.76, -5.57 in-in-in SNCiii in-in ActLoopNT-in 2.7611 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.27, 154.57 APE9-dihe-na 136.39, -174.77 APE8-dihe-in -105.71, 113.39 APE8-rot-in 307.95 APE67-dihe-in -62.18, -16.27 -43.76, -50.15 APE12-dist-in 9.8803 APE11-dist-in 12.0547 APE10-dist-in 6.6597 APE9-dist-in 4.1698 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.74 0.182 0.207 C 320.0 278.0 19 30 24 6 [[183, 456]] 1.0 6uya Homo sapiens TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8W3WA Q9NWZ3 162 460 460.0 A1AFO:501 Type1 Active DFGin 6.8581 14.0412 BLAminus -128.73, 174.74 62.23, 85.48 -101.5, 16.16 305.37, 100.31 -63.72, -27.31 in-in in 8.9043 Saltbr-in 3.2317 HRD-in -68.06, -48.89 74.72, -0.26 in-in-in SNCiii in-in ActLoopNT-in 2.8542 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.76, 159.98 APE9-dihe-na 131.71, -173.57 APE8-dihe-in -107.82, 112.48 APE8-rot-in 308.89 APE67-dihe-in -63.58, -17.69 -42.9, -48.96 APE12-dist-in 10.1032 APE11-dist-in 11.7358 APE10-dist-in 6.3675 APE9-dist-in 3.8724 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.976 0.193 0.213 A 323.0 299.0 0 30 30 0 [[183, 456]] 1.0 8w3w Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8W3WB Q9NWZ3 162 459 460.0 A1AFO:501 Type1 Active DFGin 6.7872 14.0994 BLAminus -127.88, 176.03 61.89, 85.58 -101.74, 15.62 305.04, 100.67 -63.48, -27.05 in-in in 8.8783 Saltbr-in 3.3871 HRD-in -68.38, -48.99 75.54, -0.65 in-in-in SNCiii in-in ActLoopNT-in 2.8671 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.98, 161.44 APE9-dihe-na 131.52, -174.84 APE8-dihe-in -106.58, 111.93 APE8-rot-in 306.6 APE67-dihe-in -64.29, -18.3 -40.73, -48.94 APE12-dist-in 10.0498 APE11-dist-in 11.763 APE10-dist-in 6.369 APE9-dist-in 3.796 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.976 0.193 0.213 B 323.0 289.0 9 30 25 5 [[183, 456]] 1.0 8w3w Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8W3WC Q9NWZ3 164 459 460.0 A1AFO:501 Type1 Active DFGin 6.9447 14.0277 BLAminus -131.5, 174.28 63.48, 84.98 -101.2, 15.78 305.71, 101.49 -64.51, -27.86 in-in in 9.1267 Saltbr-in 3.4906 HRD-in -68.01, -49.84 76.05, -0.43 in-in-in SNCiii in-in ActLoopNT-in 2.8494 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.49, 159.76 APE9-dihe-na 131.52, -174.5 APE8-dihe-in -107.14, 112.54 APE8-rot-in 309.3 APE67-dihe-in -64.01, -18.26 -41.84, -47.74 APE12-dist-in 10.0809 APE11-dist-in 11.8818 APE10-dist-in 6.4663 APE9-dist-in 3.8706 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.976 0.193 0.213 C 323.0 288.0 8 30 26 4 [[183, 456]] 1.0 8w3w Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8W3WD Q9NWZ3 164 459 460.0 A1AFO:501 Type1 Active DFGin 6.892 13.9874 BLAminus -130.3, 174.83 63.6, 85.05 -101.8, 16.17 305.68, 100.86 -64.29, -27.61 in-in in 8.9427 Saltbr-in 3.3493 HRD-in -68.44, -48.97 76.22, -0.96 in-in-in SNCiii in-in ActLoopNT-in 2.8502 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.54, 160.0 APE9-dihe-na 132.11, -172.93 APE8-dihe-in -108.54, 112.3 APE8-rot-in 308.85 APE67-dihe-in -64.64, -17.79 -42.26, -47.29 APE12-dist-in 9.9975 APE11-dist-in 11.755 APE10-dist-in 6.4015 APE9-dist-in 3.9192 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.976 0.193 0.213 D 323.0 287.0 9 30 26 4 [[183, 456]] 1.0 8w3w Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8ATLAAA Q9NWZ3 165 459 460.0 O6X:1001 Type1 Active DFGin 6.8629 14.0415 BLAminus -137.77, 171.28 65.58, 85.32 -106.59, 14.48 304.55, 90.88 -55.82, -34.42 in-in in 9.1164 Saltbr-in 3.5432 HRD-in -70.47, -58.64 81.65, 11.33 in-in-in SNCiii in-in ActLoopNT-in 2.8678 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.86, 150.6 APE9-dihe-na 144.35, -175.33 APE8-dihe-in -104.94, 114.45 APE8-rot-in 316.2 APE67-dihe-in -61.27, -24.68 -62.06, -32.75 APE12-dist-in 10.2616 APE11-dist-in 11.7876 APE10-dist-in 6.8529 APE9-dist-in 4.0524 K400A,E401A,E402A TPO345,SEP346 CSO240,TPO345,SEP346 XRAY 2.464 0.201 0.243 AAA 298.0 282.0 13 30 23 7 [[183, 456]] 1.0 8atl Homo sapiens TKL_IRAK4_HUMAN TKL 1.3e-83 286.6 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8ATLBBB Q9NWZ3 165 459 460.0 O6X:1001 Type1 Active DFGin 7.0962 13.9429 BLAminus -128.06, 169.98 67.88, 82.87 -108.63, 28.43 316.44, 98.21 -70.71, -32.03 in-in in 8.9827 Saltbr-in 2.8484 HRD-in -68.78, -54.88 81.51, -3.35 in-in-in SNCiii in-in ActLoopNT-in 3.0516 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.25, 137.09 APE9-dihe-na 154.06, -169.33 APE8-dihe-in -119.2, 107.5 APE8-rot-in 319.15 APE67-dihe-in -65.1, -18.02 -48.25, -46.08 APE12-dist-in 10.238 APE11-dist-in 11.6885 APE10-dist-in 6.5229 APE9-dist-in 4.3488 K400A,E401A,E402A TPO345,SEP346 TPO345,SEP346 XRAY 2.464 0.201 0.243 BBB 298.0 271.0 24 30 23 7 [[183, 456]] 1.0 8atl Homo sapiens TKL_IRAK4_HUMAN TKL 1.3e-83 286.6 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6EGEA Q9NWZ3 165 459 460.0 DL1:60501 Type1 Active DFGin 6.9399 14.5554 BLAminus -135.12, -165.28 63.61, 72.4 -102.34, 15.54 280.06, 84.72 -58.95, -24.98 in-in in 8.8526 Saltbr-in 2.8056 HRD-in -77.76, -48.68 75.86, 2.37 in-in-in SNCiii in-in ActLoopNT-in 2.7403 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.44, 145.15 APE9-dihe-na 161.1, -176.09 APE8-dihe-in -100.19, 114.19 APE8-rot-in 298.83 APE67-dihe-in -69.58, -10.0 -51.22, -43.25 APE12-dist-in 10.1892 APE11-dist-in 11.5967 APE10-dist-in 6.6726 APE9-dist-in 4.0972 None None None XRAY 1.401 0.179 0.201 A 302.0 270.0 25 30 19 11 [[183, 456]] 1.0 6ege Homo sapiens TKL_IRAK4_HUMAN TKL 2.6e-83 285.5 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5T1SB Q9NWZ3 161 459 460.0 76Q:9901 Type1.5_Back Active DFGin 6.8475 14.1018 BLAminus -131.29, 172.67 63.73, 85.01 -103.62, 20.27 304.8, 98.39 -63.0, -38.49 in-in in 8.7432 Saltbr-in 2.8534 HRD-in -68.0, -50.7 78.25, -4.83 in-in-in SNCiii in-in ActLoopNT-in 2.7693 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.12, 154.96 APE9-dihe-na 137.49, -168.77 APE8-dihe-in -112.44, 114.13 APE8-rot-in 311.51 APE67-dihe-in -62.57, -16.72 -41.02, -52.25 APE12-dist-in 9.8992 APE11-dist-in 11.6424 APE10-dist-in 6.2292 APE9-dist-in 3.7675 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.207 0.223 B 301.0 285.0 14 30 25 5 [[183, 456]] 1.0 5t1s Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 2OIDA Q9NWZ3 164 458 460.0 ANP:1 ATPlike Inactive DFGin 6.9661 14.6844 BLAminus -127.55, 175.38 65.24, 82.27 -102.22, 23.11 306.08, 83.19 -64.75, -29.47 out-out out 11.8323 Saltbr-out 5.6903 HRD-in -73.12, -50.9 80.09, -6.55 out-in-in SNCoii in-in ActLoopNT-in 2.8231 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.88, 151.66 APE9-dihe-na 147.16, -164.5 APE8-dihe-in -113.74, 115.19 APE8-rot-in 308.34 APE67-dihe-in -64.44, -17.27 -37.39, -54.71 APE12-dist-in 9.8258 APE11-dist-in 11.5381 APE10-dist-in 6.0721 APE9-dist-in 3.8073 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.244 0.295 A 301.0 266.0 29 30 26 4 [[183, 456]] 1.0 2oid Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 2OIDB Q9NWZ3 164 459 460.0 ANP:2 ATPlike Inactive DFGin 6.94 14.7103 BLAminus -122.34, 171.98 72.6, 82.12 -104.43, 15.54 299.16, 90.11 -59.64, -29.05 in-out in 8.9076 Saltbr-out 3.9298 HRD-in -75.58, -47.6 78.52, -5.87 out-in-in SNCoii in-in ActLoopNT-in 2.7304 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.71, 158.05 APE9-dihe-na 142.8, -157.21 APE8-dihe-in -121.23, 117.8 APE8-rot-in 309.19 APE67-dihe-in -67.67, -11.87 -44.28, -49.35 APE12-dist-in 10.1904 APE11-dist-in 11.7427 APE10-dist-in 6.5221 APE9-dist-in 3.7233 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.244 0.295 B 301.0 274.0 22 30 24 6 [[183, 456]] 1.0 2oid Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 2OIDC Q9NWZ3 166 458 460.0 ANP:3 ATPlike Inactive DFGin 6.806 13.9727 BLAminus -130.4, 175.52 61.07, 75.53 -96.05, 32.37 309.84, 82.72 -74.67, -28.22 in-out in 8.9014 Saltbr-out 4.0238 HRD-in -62.6, -55.98 80.8, 1.53 out-in-in SNCoii in-in ActLoopNT-in 3.032 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.92, 158.28 APE9-dihe-na 138.01, -176.06 APE8-dihe-in -106.21, 116.22 APE8-rot-in 304.08 APE67-dihe-in -63.21, -15.57 -55.27, -41.4 APE12-dist-in 9.6871 APE11-dist-in 11.4204 APE10-dist-in 6.3612 APE9-dist-in 3.8779 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.244 0.295 C 301.0 259.0 34 30 24 6 [[183, 456]] 1.0 2oid Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 7C2WA Q9NWZ3 164 458 460.0 YTH:345,FJ9:501 Allosteric,Type1 Inactive DFGin 7.0081 14.1007 BLAminus -138.82, 174.74 56.43, 93.02 -113.13, 26.12 310.56, 79.64 -63.58, -29.99 in-out in 8.5567 Saltbr-out 5.7898 HRD-in -76.31, -45.04 70.93, 17.16 out-in-in SNCoii in-in ActLoopNT-in 2.9224 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -98.24, 170.16 APE9-dihe-na 117.69, -175.19 APE8-dihe-in -120.66, 113.54 APE8-rot-in 311.23 APE67-dihe-in -56.83, -22.49 -39.44, -59.61 APE12-dist-in 9.3821 APE11-dist-in 11.4744 APE10-dist-in 6.0252 APE9-dist-in 3.9123 None SEP346 YTH345,SEP346 XRAY 3.2 0.266 0.355 A 296.0 295.0 0 30 30 0 [[183, 456]] 1.0 7c2w Homo sapiens TKL_IRAK4_HUMAN TKL 3.8e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 7C2WB Q9NWZ3 163 458 460.0 YTH:345,FJ9:501 Allosteric,Type1 Inactive DFGin 6.9785 14.6116 BLAminus -136.45, 162.53 68.37, 80.41 -104.06, 37.12 313.57, 98.38 -78.22, -38.45 in-out in 9.1185 Saltbr-out 6.5735 HRD-in -83.19, -43.83 70.57, 2.83 out-in-in SNCoii in-in ActLoopNT-in 2.6388 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.34, 141.77 APE9-dihe-na 153.89, -173.46 APE8-dihe-in -107.61, 111.76 APE8-rot-in 314.98 APE67-dihe-in -66.34, -21.87 -50.88, -45.35 APE12-dist-in 10.6643 APE11-dist-in 11.5527 APE10-dist-in 6.5733 APE9-dist-in 3.7907 None SEP346 YTH345,SEP346 XRAY 3.2 0.266 0.355 B 296.0 296.0 0 30 30 0 [[183, 456]] 1.0 7c2w Homo sapiens TKL_IRAK4_HUMAN TKL 3.8e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 7C2WC Q9NWZ3 164 458 460.0 YTH:345,FJ9:501 Allosteric,Type1 Inactive DFGin 6.572 14.2817 BLAminus -111.0, 169.93 74.2, 68.59 -90.48, 38.19 306.97, 110.28 -72.84, -29.79 in-out in 8.7988 Saltbr-out 5.1436 HRD-in -81.6, -51.31 75.53, 23.82 out-in-in SNCoii in-in ActLoopNT-in 3.0948 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.53, 139.11 APE9-dihe-na 144.09, -177.78 APE8-dihe-in -103.04, 109.59 APE8-rot-in 305.86 APE67-dihe-in -65.96, -16.53 -57.46, -35.15 APE12-dist-in 10.9103 APE11-dist-in 11.7507 APE10-dist-in 6.7479 APE9-dist-in 4.2238 None SEP346 YTH345,SEP346 XRAY 3.2 0.266 0.355 C 296.0 295.0 0 30 30 0 [[183, 456]] 1.0 7c2w Homo sapiens TKL_IRAK4_HUMAN TKL 3.8e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 7C2WD Q9NWZ3 164 458 460.0 YTH:345,FJ9:501 Allosteric,Type1 Inactive DFGin 7.1196 14.474 BLAminus -122.46, 161.89 73.23, 111.34 -132.13, 33.23 304.46, 95.4 -62.48, -38.96 in-out in 8.8964 Saltbr-out 3.7048 HRD-in -82.62, -42.53 65.68, 19.17 out-in-in SNCoii in-in ActLoopNT-in 2.4233 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.21, 150.63 APE9-dihe-na 117.03, -166.09 APE8-dihe-in -99.2, 111.11 APE8-rot-in 306.68 APE67-dihe-in -65.8, -26.71 -55.01, -29.38 APE12-dist-in 10.7708 APE11-dist-in 11.4005 APE10-dist-in 6.0408 APE9-dist-in 4.3734 None SEP346 YTH345,SEP346 XRAY 3.2 0.266 0.355 D 296.0 295.0 0 30 30 0 [[183, 456]] 1.0 7c2w Homo sapiens TKL_IRAK4_HUMAN TKL 3.8e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 2O8YA Q9NWZ3 165 459 460.0 No_ligand No_ligand Inactive DFGin 6.8416 14.5911 BLAminus -132.39, 177.22 66.07, 84.3 -105.54, 20.57 305.43, 80.78 -65.44, -21.01 in-out in 9.2203 Saltbr-out 5.2604 HRD-in -67.22, -51.44 76.47, -5.87 out-in-in SNCoii in-in ActLoopNT-in 2.6453 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.99, 161.49 APE9-dihe-na 137.04, -166.6 APE8-dihe-in -112.18, 123.59 APE8-rot-in 299.28 APE67-dihe-in -59.66, -14.58 -45.01, -56.42 APE12-dist-in 10.1061 APE11-dist-in 11.7981 APE10-dist-in 6.4734 APE9-dist-in 3.6984 None TPO342,TPO345 MSE192,MSE237,MSE265,MSE287,TPO342,MSE344,TPO345,MSE355,MSE418,MSE429,MSE457 XRAY 2.4 0.246 0.289 A 298.0 280.0 15 30 25 5 [[183, 456]] 1.0 2o8y Homo sapiens TKL_IRAK4_HUMAN TKL 3.9e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 2O8YB Q9NWZ3 165 459 460.0 No_ligand No_ligand Inactive DFGin 6.9821 14.8022 BLAminus -133.86, -178.63 62.43, 89.29 -111.36, 23.7 306.19, 76.11 -69.27, -12.74 in-out in 8.717 Saltbr-out 4.0968 HRD-in -66.08, -48.44 73.53, 0.66 out-in-in SNCoii in-in ActLoopNT-in 2.8454 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.84, 167.68 APE9-dihe-na 128.52, -172.33 APE8-dihe-in -109.54, 116.11 APE8-rot-in 303.67 APE67-dihe-in -57.63, -18.12 -43.35, -51.59 APE12-dist-in 10.3467 APE11-dist-in 11.6456 APE10-dist-in 6.2992 APE9-dist-in 3.8249 None TPO342,TPO345 MSE192,MSE237,MSE265,MSE287,TPO342,MSE344,TPO345,MSE355,MSE418,MSE429,MSE457 XRAY 2.4 0.246 0.289 B 298.0 277.0 18 30 26 4 [[183, 456]] 1.0 2o8y Homo sapiens TKL_IRAK4_HUMAN TKL 3.9e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 2OIBB Q9NWZ3 164 459 460.0 No_ligand No_ligand Inactive DFGin 6.9115 14.3665 BLAminus -130.73, 177.63 60.98, 89.06 -107.76, 18.75 304.42, 96.69 -61.49, -32.17 in-out in 8.7105 Saltbr-out 4.9735 HRD-in -73.5, -47.34 78.41, -6.88 out-in-in SNCoii in-in ActLoopNT-in 2.603 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.65, 163.49 APE9-dihe-na 129.0, -175.48 APE8-dihe-in -112.62, 115.8 APE8-rot-in 312.17 APE67-dihe-in -59.96, -17.14 -45.91, -50.69 APE12-dist-in 10.1468 APE11-dist-in 11.7665 APE10-dist-in 6.2429 APE9-dist-in 3.6764 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.0 0.224 0.27 B 301.0 280.0 16 30 25 5 [[183, 456]] 1.0 2oib Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 2OIBD Q9NWZ3 162 459 460.0 No_ligand No_ligand Inactive DFGin 6.869 14.1067 BLAminus -132.48, 179.0 58.57, 90.78 -108.79, 13.93 305.25, 93.63 -59.23, -27.46 in-out in 8.5749 Saltbr-out 3.9104 HRD-in -70.94, -53.7 84.55, -7.25 out-in-in SNCoii in-in ActLoopNT-in 2.7686 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.13, 162.11 APE9-dihe-na 127.99, -173.2 APE8-dihe-in -112.52, 109.59 APE8-rot-in 304.94 APE67-dihe-in -66.63, -13.02 -35.96, -52.59 APE12-dist-in 10.1459 APE11-dist-in 11.7056 APE10-dist-in 6.2291 APE9-dist-in 3.8573 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.0 0.224 0.27 D 301.0 291.0 7 30 30 0 [[183, 456]] 1.0 2oib Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6F3DA Q9NWZ3 164 458 460.0 CJT:502 Type1 Inactive DFGin 6.8568 14.9701 BLAminus -126.43, 173.85 60.13, 90.52 -108.92, 21.74 303.63, 100.05 -64.69, -33.45 in-out in 8.7483 Saltbr-out 7.0584 HRD-in -69.56, -52.85 80.84, -6.56 out-in-in SNCoii in-in ActLoopNT-in 2.7424 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.18, 157.03 APE9-dihe-na 132.14, -169.02 APE8-dihe-in -110.38, 114.0 APE8-rot-in 313.11 APE67-dihe-in -62.64, -17.73 -54.17, -36.33 APE12-dist-in 9.7838 APE11-dist-in 11.7103 APE10-dist-in 6.2087 APE9-dist-in 3.7231 None TPO345,SEP346 TPO345,SEP346 XRAY 2.38 0.199 0.227 A 295.0 279.0 16 30 23 7 [[183, 456]] 1.0 6f3d Homo sapiens TKL_IRAK4_HUMAN TKL 3.8e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6F3DB Q9NWZ3 164 458 460.0 CJT:502 Type1 Inactive DFGin 6.9062 14.8413 BLAminus -125.62, 174.19 59.72, 91.48 -109.06, 21.2 303.98, 99.18 -64.05, -33.92 in-out in 8.7272 Saltbr-out 6.88 HRD-in -68.72, -52.8 80.28, -5.29 out-in-in SNCoii in-in ActLoopNT-in 2.7186 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.53, 156.8 APE9-dihe-na 131.54, -170.51 APE8-dihe-in -110.25, 113.69 APE8-rot-in 313.84 APE67-dihe-in -63.36, -18.29 -54.74, -34.7 APE12-dist-in 9.7719 APE11-dist-in 11.4492 APE10-dist-in 5.984 APE9-dist-in 3.7841 None TPO345,SEP346 TPO345,SEP346 XRAY 2.38 0.199 0.227 B 295.0 285.0 10 30 23 7 [[183, 456]] 1.0 6f3d Homo sapiens TKL_IRAK4_HUMAN TKL 3.8e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6F3EA Q9NWZ3 164 458 460.0 CJQ:502 Type1 Inactive DFGin 6.9195 14.2196 BLAminus -136.23, 176.33 63.94, 83.09 -106.72, 21.4 311.25, 94.04 -69.13, -19.86 in-out in 8.6751 Saltbr-out 6.7089 HRD-in -63.75, -48.88 78.04, -8.73 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.08, 140.42 APE9-dihe-na 140.98, -176.61 APE8-dihe-in -92.66, 119.69 APE8-rot-in 314.49 APE67-dihe-in -63.0, -18.03 -56.97, -37.35 APE12-dist-in 10.5652 APE11-dist-in 11.8395 APE10-dist-in 6.6189 APE9-dist-in 4.1748 None TPO342,TPO345 TPO342,TPO345 XRAY 2.67 0.201 0.254 A 295.0 272.0 23 30 22 8 [[183, 456]] 1.0 6f3e Homo sapiens TKL_IRAK4_HUMAN TKL 3.8e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6F3EB Q9NWZ3 164 458 460.0 CJQ:501 Type1 Inactive DFGin 6.9236 14.146 BLAminus -136.52, 172.28 70.33, 84.0 -110.15, 21.49 311.14, 94.15 -69.02, -20.02 in-out in 8.6523 Saltbr-out 5.4897 HRD-in -63.87, -48.98 77.6, -8.2 out-in-in SNCoii in-in ActLoopNT-in 2.7351 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.45, 141.04 APE9-dihe-na 142.02, -175.79 APE8-dihe-in -93.38, 119.46 APE8-rot-in 315.35 APE67-dihe-in -63.37, -18.21 -57.51, -36.62 APE12-dist-in 10.4116 APE11-dist-in 11.628 APE10-dist-in 6.5015 APE9-dist-in 4.2208 None TPO342,TPO345 TPO342,TPO345 XRAY 2.67 0.201 0.254 B 295.0 284.0 11 30 25 5 [[183, 456]] 1.0 6f3e Homo sapiens TKL_IRAK4_HUMAN TKL 3.8e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6N8GB Q9NWZ3 164 459 460.0 KFD:501 Type1 Inactive DFGin 6.6281 14.1098 BLAminus -131.69, 166.82 75.96, 91.11 -108.83, 12.45 307.58, 107.24 -56.0, -36.28 in-out in 8.7951 Saltbr-out 3.6551 HRD-in -73.96, -48.59 79.13, -6.97 out-in-in SNCoii in-in ActLoopNT-in 2.8853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.24, 163.81 APE9-dihe-na 129.93, -172.68 APE8-dihe-in -114.06, 121.63 APE8-rot-in 306.03 APE67-dihe-in -58.98, -19.75 -56.52, -43.04 APE12-dist-in 9.8694 APE11-dist-in 12.0081 APE10-dist-in 6.4514 APE9-dist-in 3.6106 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.0 0.177 0.22 B 297.0 286.0 10 30 25 5 [[183, 456]] 1.0 6n8g Homo sapiens TKL_IRAK4_HUMAN TKL 3.9e-84 288.3 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8BR5AAA Q9NWZ3 163 459 460.0 R73:501 Type1 Inactive DFGin 6.8909 13.5487 BLAminus -135.64, 166.52 72.95, 87.11 -114.61, 20.95 314.97, 96.05 -63.79, -34.13 in-out in 8.5773 Saltbr-out 5.1263 HRD-in -65.01, -58.54 82.12, 4.04 out-in-in SNCoii in-in ActLoopNT-in 2.6426 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.82, 159.99 APE9-dihe-na 128.75, -171.24 APE8-dihe-in -115.19, 111.48 APE8-rot-in 311.1 APE67-dihe-in -62.63, -23.51 -40.08, -50.26 APE12-dist-in 9.8978 APE11-dist-in 11.8187 APE10-dist-in 6.2927 APE9-dist-in 3.5113 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.7 0.215 0.254 AAA 299.0 285.0 12 30 26 4 [[183, 456]] 1.0 8br5 Homo sapiens TKL_IRAK4_HUMAN TKL 4e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8BR5BBB Q9NWZ3 162 459 460.0 R73:501 Type1 Inactive DFGin 6.8575 13.7617 BLAminus -136.08, 166.61 73.3, 87.27 -114.6, 19.85 314.86, 95.64 -65.31, -30.39 in-out in 8.5226 Saltbr-out 3.7294 HRD-in -65.19, -58.29 82.32, 3.9 out-in-in SNCoii in-in ActLoopNT-in 3.1133 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.6, 159.09 APE9-dihe-na 128.61, -173.24 APE8-dihe-in -115.27, 111.19 APE8-rot-in 312.87 APE67-dihe-in -62.24, -23.3 -41.16, -49.65 APE12-dist-in 10.2149 APE11-dist-in 11.8096 APE10-dist-in 6.2677 APE9-dist-in 3.5494 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.7 0.215 0.254 BBB 299.0 286.0 12 30 25 5 [[183, 456]] 1.0 8br5 Homo sapiens TKL_IRAK4_HUMAN TKL 4e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8BR5CCC Q9NWZ3 163 459 460.0 R73:501 Type1 Inactive DFGin 6.708 13.7926 BLAminus -136.19, 166.86 72.98, 86.7 -114.08, 20.57 315.82, 89.7 -62.71, -31.97 in-out in 8.6814 Saltbr-out 3.7563 HRD-in -65.25, -58.07 82.96, 3.39 out-in-in SNCoii in-in ActLoopNT-in 2.958 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.36, 158.08 APE9-dihe-na 127.09, -172.58 APE8-dihe-in -114.98, 111.31 APE8-rot-in 311.74 APE67-dihe-in -61.49, -24.18 -41.35, -49.9 APE12-dist-in 10.074 APE11-dist-in 11.8248 APE10-dist-in 6.1654 APE9-dist-in 3.5104 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.7 0.215 0.254 CCC 299.0 284.0 13 30 24 6 [[183, 456]] 1.0 8br5 Homo sapiens TKL_IRAK4_HUMAN TKL 4e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8BR5DDD Q9NWZ3 164 459 460.0 R73:501 Type1 Inactive DFGin 6.9291 13.6331 BLAminus -135.77, 166.02 73.96, 87.25 -114.76, 19.82 314.36, 95.52 -65.27, -32.15 in-out in 8.387 Saltbr-out 3.6821 HRD-in -64.82, -58.41 82.56, 3.65 out-in-in SNCoii in-in ActLoopNT-in 2.6458 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.87, 159.3 APE9-dihe-na 128.38, -172.65 APE8-dihe-in -115.23, 111.34 APE8-rot-in 311.38 APE67-dihe-in -63.77, -22.78 -39.6, -50.55 APE12-dist-in 9.8784 APE11-dist-in 11.8965 APE10-dist-in 6.3607 APE9-dist-in 3.5306 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.7 0.215 0.254 DDD 299.0 285.0 11 30 26 4 [[183, 456]] 1.0 8br5 Homo sapiens TKL_IRAK4_HUMAN TKL 4e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4XS2A Q9NWZ3 163 459 460.0 42P:501 Type1 Inactive DFGin 6.9606 13.8175 BLAminus -139.83, 178.59 62.42, 89.38 -110.92, 32.37 305.3, 93.64 -72.26, -32.74 in-out in 8.1825 Saltbr-out 3.8869 HRD-in -66.15, -47.6 71.03, 8.51 out-in-in SNCoii in-in ActLoopNT-in 2.7232 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.97, 150.86 APE9-dihe-na 147.38, -162.61 APE8-dihe-in -121.73, 101.64 APE8-rot-in 312.4 APE67-dihe-in -60.48, -25.99 -31.6, -51.75 APE12-dist-in 10.2037 APE11-dist-in 11.5946 APE10-dist-in 6.3636 APE9-dist-in 3.8944 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.73 0.265 0.285 A 301.0 286.0 11 30 26 4 [[183, 456]] 1.0 4xs2 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4XS2C Q9NWZ3 164 460 460.0 42P:501 Type1 Inactive DFGin 7.0029 14.1829 BLAminus -139.75, 179.01 62.21, 89.32 -110.78, 33.07 304.95, 93.8 -72.17, -33.09 in-out in 8.9033 Saltbr-out 4.9313 HRD-in -66.02, -47.7 71.09, 8.03 out-in-in SNCoii in-in ActLoopNT-in 2.7233 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.28, 151.46 APE9-dihe-na 147.22, -162.81 APE8-dihe-in -121.29, 101.83 APE8-rot-in 312.18 APE67-dihe-in -59.63, -26.92 -31.63, -51.62 APE12-dist-in 10.0762 APE11-dist-in 11.6006 APE10-dist-in 6.3679 APE9-dist-in 3.8956 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.73 0.265 0.285 C 301.0 284.0 13 30 26 4 [[183, 456]] 1.0 4xs2 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4XS2D Q9NWZ3 164 459 460.0 42P:501 Type1 Inactive DFGin 7.0245 14.0469 BLAminus -139.44, 179.02 62.41, 89.35 -110.92, 32.6 305.38, 93.57 -72.63, -32.43 in-out in 8.8747 Saltbr-out 3.8974 HRD-in -65.82, -48.05 71.33, 8.53 out-in-in SNCoii in-in ActLoopNT-in 2.7249 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.39, 151.35 APE9-dihe-na 147.15, -162.94 APE8-dihe-in -121.47, 101.64 APE8-rot-in 312.23 APE67-dihe-in -59.77, -26.66 -31.67, -51.78 APE12-dist-in 10.2268 APE11-dist-in 11.5759 APE10-dist-in 6.3602 APE9-dist-in 3.9119 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.73 0.265 0.285 D 301.0 280.0 16 30 25 5 [[183, 456]] 1.0 4xs2 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4YO6A Q9NWZ3 163 459 460.0 4GD:501 Type1 Inactive DFGin 6.8617 13.9601 BLAminus -129.91, 177.67 60.76, 83.02 -105.78, 15.82 308.47, 100.26 -61.62, -37.54 in-out in 8.6354 Saltbr-out 3.7566 HRD-in -64.27, -52.67 78.0, -3.84 out-in-in SNCoii in-in ActLoopNT-in 2.6627 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.75, 154.49 APE9-dihe-na 134.67, -169.9 APE8-dihe-in -113.48, 114.93 APE8-rot-in 316.38 APE67-dihe-in -59.93, -21.93 -40.75, -53.54 APE12-dist-in 9.8108 APE11-dist-in 11.7169 APE10-dist-in 6.295 APE9-dist-in 3.7922 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.32 0.199 0.225 A 301.0 289.0 8 30 27 3 [[183, 456]] 1.0 4yo6 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4YO6C Q9NWZ3 164 460 460.0 4GD:501 Type1 Inactive DFGin 6.9084 14.067 BLAminus -128.29, 178.22 59.78, 82.76 -103.95, 17.07 307.43, 101.27 -61.63, -37.69 in-out in 8.812 Saltbr-out 4.7022 HRD-in -64.18, -52.59 77.65, -3.55 out-in-in SNCoii in-in ActLoopNT-in 2.6722 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.3, 157.9 APE9-dihe-na 134.38, -169.38 APE8-dihe-in -113.09, 114.58 APE8-rot-in 315.5 APE67-dihe-in -61.27, -21.5 -39.75, -52.67 APE12-dist-in 9.9432 APE11-dist-in 11.7304 APE10-dist-in 6.2981 APE9-dist-in 3.7593 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.32 0.199 0.225 C 301.0 289.0 8 30 25 5 [[183, 456]] 1.0 4yo6 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4YP8B Q9NWZ3 161 459 460.0 4GF:501 Type1 Inactive DFGin 6.9172 14.4445 BLAminus -129.86, 179.56 60.17, 77.95 -104.22, 26.32 310.53, 95.0 -66.78, -33.18 in-out in 8.6851 Saltbr-out 3.9622 HRD-in -57.85, -50.75 76.66, -4.15 out-in-in SNCoii in-in ActLoopNT-in 2.8535 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.74, 150.82 APE9-dihe-na 140.12, -173.75 APE8-dihe-in -103.4, 115.49 APE8-rot-in 310.63 APE67-dihe-in -65.34, -17.03 -41.64, -51.23 APE12-dist-in 10.0453 APE11-dist-in 11.5809 APE10-dist-in 6.3191 APE9-dist-in 3.9048 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 B 301.0 281.0 18 30 24 6 [[183, 456]] 1.0 4yp8 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4YP8C Q9NWZ3 164 460 460.0 4GF:501 Type1 Inactive DFGin 6.8212 14.4085 BLAminus -129.81, 179.51 59.35, 79.05 -103.24, 26.6 309.61, 96.69 -66.38, -34.02 in-out in 8.8507 Saltbr-out 4.6837 HRD-in -59.31, -50.52 77.45, -5.42 out-in-in SNCoii in-in ActLoopNT-in 2.7895 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.88, 150.51 APE9-dihe-na 141.79, -174.18 APE8-dihe-in -103.25, 114.63 APE8-rot-in 311.45 APE67-dihe-in -64.61, -17.76 -41.38, -51.75 APE12-dist-in 10.1488 APE11-dist-in 11.6263 APE10-dist-in 6.34 APE9-dist-in 3.9449 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 C 301.0 290.0 7 30 26 4 [[183, 456]] 1.0 4yp8 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4YP8D Q9NWZ3 164 459 460.0 4GF:501 Type1 Inactive DFGin 6.8543 14.3193 BLAminus -129.62, 178.91 61.84, 77.53 -103.67, 26.43 310.15, 95.74 -66.28, -34.21 in-out in 8.9151 Saltbr-out 3.8024 HRD-in -59.75, -49.91 75.93, -3.95 out-in-in SNCoii in-in ActLoopNT-in 2.7897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.59, 153.02 APE9-dihe-na 138.42, -174.86 APE8-dihe-in -103.4, 114.55 APE8-rot-in 310.75 APE67-dihe-in -64.11, -17.03 -41.21, -51.68 APE12-dist-in 10.0152 APE11-dist-in 11.5854 APE10-dist-in 6.3272 APE9-dist-in 3.9224 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 D 301.0 288.0 8 30 26 4 [[183, 456]] 1.0 4yp8 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4ZTLD Q9NWZ3 164 460 460.0 4S1:501 Type1 Inactive DFGin 7.408 13.8584 BLAminus -116.1, 179.03 57.27, 97.63 -119.15, 26.56 307.31, 90.9 -69.0, -33.74 in-out in 8.834 Saltbr-out 4.0326 HRD-in -66.21, -53.23 78.61, -4.19 out-in-in SNCoii in-in ActLoopNT-in 2.759 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.29, 153.79 APE9-dihe-na 136.38, -168.38 APE8-dihe-in -115.43, 114.11 APE8-rot-in 309.49 APE67-dihe-in -62.14, -19.04 -39.35, -53.51 APE12-dist-in 9.8775 APE11-dist-in 11.6541 APE10-dist-in 6.2719 APE9-dist-in 3.739 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.39 0.226 0.251 D 301.0 288.0 9 30 26 4 [[183, 456]] 1.0 4ztl Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4ZTMC Q9NWZ3 164 460 460.0 4S2:501 Type1 Inactive DFGin 7.0479 13.9738 BLAminus -126.04, 176.22 63.0, 87.68 -110.92, 16.43 306.51, 93.12 -61.69, -39.3 in-out in 8.6617 Saltbr-out 3.7253 HRD-in -70.81, -43.23 73.84, -1.89 out-in-in SNCoii in-in ActLoopNT-in 2.6646 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.63, 152.69 APE9-dihe-na 136.92, -172.96 APE8-dihe-in -111.3, 109.86 APE8-rot-in 307.24 APE67-dihe-in -64.59, -17.33 -36.72, -48.95 APE12-dist-in 9.9325 APE11-dist-in 11.7469 APE10-dist-in 6.2763 APE9-dist-in 3.8108 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.66 0.195 0.226 C 301.0 285.0 12 30 26 4 [[183, 456]] 1.0 4ztm Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4ZTNA Q9NWZ3 163 459 460.0 4S3:501 Type1 Inactive DFGin 6.9122 13.7481 BLAminus -132.76, 175.45 64.22, 82.16 -105.35, 20.86 308.35, 101.07 -66.05, -41.88 in-out in 8.6944 Saltbr-out 3.9124 HRD-in -63.92, -51.66 76.82, -0.35 out-in-in SNCoii in-in ActLoopNT-in 2.7616 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.06, 158.04 APE9-dihe-na 129.58, -170.0 APE8-dihe-in -113.45, 112.1 APE8-rot-in 310.07 APE67-dihe-in -62.7, -20.05 -38.09, -52.45 APE12-dist-in 9.814 APE11-dist-in 11.7179 APE10-dist-in 6.2346 APE9-dist-in 3.8197 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.23 0.21 0.224 A 301.0 289.0 8 30 26 4 [[183, 456]] 1.0 4ztn Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4ZTNC Q9NWZ3 164 460 460.0 4S3:501 Type1 Inactive DFGin 6.9885 13.9156 BLAminus -131.78, 175.79 64.01, 82.42 -105.46, 21.38 307.95, 100.83 -65.91, -41.86 in-out in 8.7626 Saltbr-out 5.2416 HRD-in -64.24, -51.41 76.71, -0.47 out-in-in SNCoii in-in ActLoopNT-in 2.7669 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.03, 158.37 APE9-dihe-na 130.24, -169.83 APE8-dihe-in -112.97, 111.72 APE8-rot-in 309.39 APE67-dihe-in -62.29, -20.6 -37.85, -52.05 APE12-dist-in 9.8427 APE11-dist-in 11.7416 APE10-dist-in 6.2439 APE9-dist-in 3.8114 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.23 0.21 0.224 C 301.0 287.0 10 30 25 5 [[183, 456]] 1.0 4ztn Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4ZTND Q9NWZ3 164 459 460.0 4S3:501 Type1 Inactive DFGin 6.9666 13.8616 BLAminus -131.47, 175.86 63.89, 82.53 -105.44, 21.0 308.32, 101.14 -65.65, -42.51 in-out in 8.5619 Saltbr-out 4.5879 HRD-in -64.48, -51.67 77.17, -0.49 out-in-in SNCoii in-in ActLoopNT-in 2.7672 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.0, 157.79 APE9-dihe-na 130.37, -169.74 APE8-dihe-in -112.98, 111.75 APE8-rot-in 309.39 APE67-dihe-in -62.26, -20.04 -38.34, -52.0 APE12-dist-in 9.8419 APE11-dist-in 11.7142 APE10-dist-in 6.2313 APE9-dist-in 3.8469 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.23 0.21 0.224 D 301.0 288.0 8 30 26 4 [[183, 456]] 1.0 4ztn Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5K75B Q9NWZ3 163 458 460.0 6QX:504 Type1 Inactive DFGin 6.9421 14.4597 BLAminus -128.01, 170.74 65.21, 84.11 -102.46, 21.31 309.47, 102.25 -65.48, -35.7 in-out in 8.9911 Saltbr-out 4.824 HRD-in -67.05, -49.26 79.32, -10.55 out-in-in SNCoii in-in ActLoopNT-in 2.8439 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.97, 151.22 APE9-dihe-na 136.05, -171.59 APE8-dihe-in -107.24, 112.63 APE8-rot-in 315.34 APE67-dihe-in -64.6, -19.05 -39.76, -49.9 APE12-dist-in 10.3108 APE11-dist-in 11.9727 APE10-dist-in 6.4513 APE9-dist-in 3.9883 None TPO345,SEP346 TPO345,SEP346 XRAY 2.03 0.24 0.253 B 301.0 276.0 20 30 24 6 [[183, 456]] 1.0 5k75 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5K75C Q9NWZ3 164 458 460.0 6QX:503 Type1 Inactive DFGin 6.8715 14.6093 BLAminus -129.83, 165.29 65.74, 85.81 -102.99, 19.43 308.09, 104.56 -63.96, -32.44 in-out in 9.2956 Saltbr-out 5.3423 HRD-in -68.14, -49.27 78.52, -10.11 out-in-in SNCoii in-in ActLoopNT-in 2.8545 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.89, 149.58 APE9-dihe-na 136.24, -173.39 APE8-dihe-in -107.03, 113.02 APE8-rot-in 310.39 APE67-dihe-in -64.46, -18.84 -41.97, -48.83 APE12-dist-in 10.2092 APE11-dist-in 11.9086 APE10-dist-in 6.4163 APE9-dist-in 3.9225 None TPO345,SEP346 TPO345,SEP346 XRAY 2.03 0.24 0.253 C 301.0 284.0 11 30 24 6 [[183, 456]] 1.0 5k75 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5K75D Q9NWZ3 164 458 460.0 6QX:503 Type1 Inactive DFGin 6.8707 14.653 BLAminus -129.48, 170.81 65.18, 85.95 -104.57, 20.05 308.12, 102.19 -64.37, -31.42 in-out in 9.3321 Saltbr-out 6.1167 HRD-in -68.05, -50.39 79.24, -8.5 out-in-in SNCoii in-in ActLoopNT-in 2.8485 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.04, 148.95 APE9-dihe-na 137.45, -171.0 APE8-dihe-in -108.28, 111.67 APE8-rot-in 312.02 APE67-dihe-in -64.11, -18.6 -47.87, -42.01 APE12-dist-in 10.0957 APE11-dist-in 11.8943 APE10-dist-in 6.4432 APE9-dist-in 4.0163 None TPO345,SEP346 TPO345,SEP346 XRAY 2.03 0.24 0.253 D 301.0 282.0 13 30 25 5 [[183, 456]] 1.0 5k75 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5K76A Q9NWZ3 165 458 460.0 6R1:501 Type1 Inactive DFGin 6.8534 14.8634 BLAminus -121.43, -179.95 54.49, 86.78 -104.23, 22.41 304.48, 98.38 -65.05, -34.55 in-out in 8.9195 Saltbr-out 3.6512 HRD-in -65.07, -46.83 74.96, -9.88 out-in-in SNCoii in-in ActLoopNT-in 2.8021 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.56, 155.66 APE9-dihe-na 131.31, -170.57 APE8-dihe-in -106.81, 113.19 APE8-rot-in 313.21 APE67-dihe-in -69.62, -11.45 -41.08, -46.98 APE12-dist-in 10.3096 APE11-dist-in 11.7027 APE10-dist-in 6.1775 APE9-dist-in 3.6795 None TPO345,SEP346 TPO345,SEP346 XRAY 2.74 0.218 0.246 A 301.0 272.0 22 30 24 6 [[183, 456]] 1.0 5k76 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5KX8C Q9NWZ3 164 460 460.0 6YE:501 Type1 Inactive DFGin 6.7104 13.6602 BLAminus -135.77, -177.74 57.62, 85.63 -110.73, 16.78 314.9, 103.1 -62.24, -34.76 in-out in 8.5149 Saltbr-out 5.49 HRD-in -63.77, -49.86 77.11, -1.48 out-in-in SNCoii in-in ActLoopNT-in 2.6554 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.71, 147.84 APE9-dihe-na 142.61, -171.78 APE8-dihe-in -109.37, 108.08 APE8-rot-in 308.72 APE67-dihe-in -61.99, -21.4 -33.87, -50.94 APE12-dist-in 9.982 APE11-dist-in 11.7199 APE10-dist-in 6.4828 APE9-dist-in 3.943 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.671 0.206 0.233 C 301.0 290.0 7 30 26 4 [[183, 456]] 1.0 5kx8 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5T1SA Q9NWZ3 163 459 460.0 76Q:9901 Type1 Inactive DFGin 6.9238 14.2156 BLAminus -131.2, 172.67 63.25, 85.32 -103.49, 19.58 304.94, 98.19 -62.83, -37.96 in-out in 8.3968 Saltbr-out 4.3357 HRD-in -67.98, -50.93 78.51, -4.97 out-in-in SNCoii in-in ActLoopNT-in 2.7268 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.42, 155.39 APE9-dihe-na 136.97, -168.9 APE8-dihe-in -113.04, 114.06 APE8-rot-in 312.08 APE67-dihe-in -62.34, -17.03 -41.2, -52.01 APE12-dist-in 10.2827 APE11-dist-in 11.6358 APE10-dist-in 6.2313 APE9-dist-in 3.7723 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.207 0.223 A 301.0 283.0 14 30 27 3 [[183, 456]] 1.0 5t1s Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5T1SC Q9NWZ3 164 460 460.0 76Q:9901 Type1 Inactive DFGin 6.925 14.585 BLAminus -131.08, 172.79 63.77, 84.62 -102.6, 19.98 305.07, 98.68 -62.65, -38.92 in-out in 9.0801 Saltbr-out 5.1382 HRD-in -67.96, -50.84 78.65, -4.29 out-in-in SNCoii in-in ActLoopNT-in 2.7708 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.17, 155.14 APE9-dihe-na 137.47, -168.59 APE8-dihe-in -112.75, 113.96 APE8-rot-in 311.75 APE67-dihe-in -62.32, -17.93 -40.65, -52.04 APE12-dist-in 9.7709 APE11-dist-in 11.6606 APE10-dist-in 6.2474 APE9-dist-in 3.771 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.207 0.223 C 301.0 287.0 10 30 25 5 [[183, 456]] 1.0 5t1s Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5T1TA Q9NWZ3 163 459 460.0 76P:9901 Type1 Inactive DFGin 6.887 13.9561 BLAminus -133.7, 176.64 67.32, 81.1 -107.48, 15.55 308.96, 93.07 -63.8, -32.84 in-out in 8.8561 Saltbr-out 4.6921 HRD-in -67.26, -50.15 75.88, -1.73 out-in-in SNCoii in-in ActLoopNT-in 2.7428 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.24, 158.51 APE9-dihe-na 129.02, -169.71 APE8-dihe-in -114.13, 114.14 APE8-rot-in 310.96 APE67-dihe-in -64.47, -17.8 -40.74, -50.47 APE12-dist-in 9.8476 APE11-dist-in 11.7553 APE10-dist-in 6.3662 APE9-dist-in 3.8797 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.34 0.207 0.228 A 301.0 286.0 11 30 24 6 [[183, 456]] 1.0 5t1t Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5T1TB Q9NWZ3 161 459 460.0 76P:9901 Type1 Inactive DFGin 6.9393 13.9935 BLAminus -132.8, 176.38 67.63, 80.73 -108.02, 15.73 309.33, 93.37 -64.25, -32.84 in-out in 8.925 Saltbr-out 4.0346 HRD-in -67.17, -50.18 76.11, -2.27 out-in-in SNCoii in-in ActLoopNT-in 2.7407 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.26, 158.14 APE9-dihe-na 129.32, -169.9 APE8-dihe-in -113.91, 113.67 APE8-rot-in 310.6 APE67-dihe-in -63.34, -18.99 -40.46, -50.32 APE12-dist-in 9.7898 APE11-dist-in 11.7618 APE10-dist-in 6.3647 APE9-dist-in 3.8778 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.34 0.207 0.228 B 301.0 283.0 16 30 25 5 [[183, 456]] 1.0 5t1t Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5T1TC Q9NWZ3 164 460 460.0 76P:9901 Type1 Inactive DFGin 6.9305 13.9526 BLAminus -133.8, 176.71 66.9, 81.1 -106.8, 16.35 308.8, 92.24 -64.12, -32.99 in-out in 8.9406 Saltbr-out 4.7923 HRD-in -66.05, -49.3 74.35, -2.18 out-in-in SNCoii in-in ActLoopNT-in 2.7376 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.21, 158.83 APE9-dihe-na 129.01, -170.01 APE8-dihe-in -113.41, 113.59 APE8-rot-in 310.43 APE67-dihe-in -64.34, -19.05 -39.55, -50.27 APE12-dist-in 9.7346 APE11-dist-in 11.7787 APE10-dist-in 6.3763 APE9-dist-in 3.8759 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.34 0.207 0.228 C 301.0 289.0 8 30 26 4 [[183, 456]] 1.0 5t1t Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5T1TD Q9NWZ3 164 459 460.0 76P:9901 Type1 Inactive DFGin 6.9694 13.9993 BLAminus -132.86, 176.93 67.54, 80.5 -108.06, 15.43 309.35, 93.29 -64.49, -32.38 in-out in 9.0752 Saltbr-out 4.2903 HRD-in -67.54, -50.03 76.03, -1.74 out-in-in SNCoii in-in ActLoopNT-in 2.7479 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.33, 157.65 APE9-dihe-na 129.81, -169.72 APE8-dihe-in -114.04, 113.72 APE8-rot-in 310.35 APE67-dihe-in -63.86, -17.96 -40.26, -50.55 APE12-dist-in 9.7798 APE11-dist-in 11.755 APE10-dist-in 6.3701 APE9-dist-in 3.8974 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.34 0.207 0.228 D 301.0 286.0 10 30 25 5 [[183, 456]] 1.0 5t1t Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4Y73A Q9NWZ3 163 459 460.0 XPY:1000 Type1 Inactive DFGin 6.7939 13.8816 BLAminus -135.22, 179.14 58.81, 74.84 -95.42, 16.11 309.59, 98.19 -56.86, -31.3 in-out in 8.6719 Saltbr-out 4.1966 HRD-in -65.11, -54.01 76.65, -4.03 out-in-in SNCoii in-in ActLoopNT-in 2.7411 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.98, 155.58 APE9-dihe-na 135.26, -172.46 APE8-dihe-in -110.18, 112.73 APE8-rot-in 310.78 APE67-dihe-in -61.03, -19.56 -40.26, -54.06 APE12-dist-in 10.1174 APE11-dist-in 11.6957 APE10-dist-in 6.3615 APE9-dist-in 4.0109 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.14 0.196 0.217 A 302.0 292.0 5 30 25 5 [[183, 456]] 1.0 4y73 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4Y73B Q9NWZ3 161 459 460.0 XPY:1000 Type1 Inactive DFGin 6.9031 13.8994 BLAminus -134.53, 179.53 58.2, 75.65 -95.32, 17.24 309.95, 97.89 -59.17, -23.79 in-out in 8.3394 Saltbr-out 3.7399 HRD-in -64.75, -51.42 74.08, -3.62 out-in-in SNCoii in-in ActLoopNT-in 2.8588 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.97, 155.19 APE9-dihe-na 135.01, -173.41 APE8-dihe-in -108.72, 112.77 APE8-rot-in 310.3 APE67-dihe-in -60.51, -19.8 -41.06, -53.91 APE12-dist-in 10.1439 APE11-dist-in 11.7409 APE10-dist-in 6.3534 APE9-dist-in 3.9692 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.14 0.196 0.217 B 302.0 292.0 7 30 23 7 [[183, 456]] 1.0 4y73 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4Y73C Q9NWZ3 164 460 460.0 XPY:1000 Type1 Inactive DFGin 6.9893 13.7959 BLAminus -135.91, 178.91 60.18, 74.45 -95.65, 17.31 309.71, 99.32 -57.1, -32.23 in-out in 8.4949 Saltbr-out 4.0135 HRD-in -67.33, -52.41 76.27, -4.09 out-in-in SNCoii in-in ActLoopNT-in 2.752 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.79, 155.49 APE9-dihe-na 134.48, -173.93 APE8-dihe-in -109.04, 112.55 APE8-rot-in 310.08 APE67-dihe-in -60.39, -19.29 -39.87, -53.77 APE12-dist-in 10.0164 APE11-dist-in 11.817 APE10-dist-in 6.4291 APE9-dist-in 3.9704 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.14 0.196 0.217 C 302.0 293.0 4 30 26 4 [[183, 456]] 1.0 4y73 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6MOMB Q9NWZ3 164 459 460.0 JX4:500 Type1 Inactive DFGin 7.1655 13.5154 BLAminus -127.54, 170.46 71.09, 82.13 -106.22, 20.82 305.71, 89.03 -65.5, -27.27 in-out in 8.5492 Saltbr-out 5.0881 HRD-in -79.93, -51.42 76.22, 2.24 out-in-in SNCoii in-in ActLoopNT-in 2.7756 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.82, 152.75 APE9-dihe-na 140.22, 179.97 APE8-dihe-in -102.97, 112.18 APE8-rot-in 307.34 APE67-dihe-in -63.75, -15.14 -58.52, -34.89 APE12-dist-in 10.1297 APE11-dist-in 12.031 APE10-dist-in 7.0099 APE9-dist-in 4.5624 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.168 0.207 B 303.0 289.0 7 30 26 4 [[183, 456]] 1.0 6mom Homo sapiens TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6MOMD Q9NWZ3 164 459 460.0 JX4:500 Type1 Inactive DFGin 6.9958 13.418 BLAminus -130.88, 172.79 70.38, 81.05 -105.81, 20.52 305.57, 94.51 -64.31, -26.67 in-out in 8.4879 Saltbr-out 4.6811 HRD-in -80.85, -51.58 75.47, 1.68 out-in-in SNCoii in-in ActLoopNT-in 2.8054 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.31, 153.05 APE9-dihe-na 140.98, -178.81 APE8-dihe-in -101.12, 113.96 APE8-rot-in 309.17 APE67-dihe-in -64.74, -14.89 -58.96, -36.24 APE12-dist-in 10.1507 APE11-dist-in 11.959 APE10-dist-in 7.0419 APE9-dist-in 4.5456 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.168 0.207 D 303.0 296.0 0 30 30 0 [[183, 456]] 1.0 6mom Homo sapiens TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 9NA2A Q9NWZ3 164 458 460.0 A1BW0:501 Type1 Inactive DFGin 6.8477 13.7307 BLAminus -129.5, 174.15 76.19, 82.37 -109.93, 12.46 306.46, 102.0 -68.06, -20.21 in-out in 8.946 Saltbr-out 6.2888 HRD-in -77.12, -53.15 78.59, 0.07 out-in-in SNCoii in-in ActLoopNT-in 2.704 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.31, 156.05 APE9-dihe-na 126.63, -176.29 APE8-dihe-in -108.96, 120.82 APE8-rot-in 296.98 APE67-dihe-in -64.68, -11.03 -61.41, -36.62 APE12-dist-in 9.905 APE11-dist-in 11.9527 APE10-dist-in 6.5317 APE9-dist-in 4.4021 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.99 0.206 0.246 A 304.0 293.0 2 30 28 2 [[183, 456]] 1.0 9na2 Homo sapiens TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 9NA2B Q9NWZ3 165 458 460.0 A1BW0:501 Type1 Inactive DFGin 6.9241 14.1302 BLAminus -134.63, 174.5 75.73, 83.38 -111.23, 11.86 301.94, 95.06 -63.77, -21.44 in-out in 8.971 Saltbr-out 6.13 HRD-in -76.54, -51.75 76.66, 1.42 out-in-in SNCoii in-in ActLoopNT-in 2.6237 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.09, 160.31 APE9-dihe-na 114.91, -171.81 APE8-dihe-in -114.31, 117.82 APE8-rot-in 292.46 APE67-dihe-in -63.01, -16.36 -51.36, -43.64 APE12-dist-in 10.1486 APE11-dist-in 11.9934 APE10-dist-in 6.6007 APE9-dist-in 4.4889 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.99 0.206 0.246 B 304.0 287.0 7 30 25 5 [[183, 456]] 1.0 9na2 Homo sapiens TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 9NA5A Q9NWZ3 162 458 460.0 A1BWY:501 Type1 Inactive DFGin 6.8573 13.7953 BLAminus -133.26, 171.01 69.04, 85.7 -105.99, 16.7 310.03, 99.89 -62.7, -22.3 in-out in 8.8572 Saltbr-out 4.4238 HRD-in -75.21, -50.97 79.25, -1.48 out-in-in SNCoii in-in ActLoopNT-in 2.6791 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.97, 159.53 APE9-dihe-na 136.23, -177.51 APE8-dihe-in -108.28, 116.32 APE8-rot-in 306.12 APE67-dihe-in -69.45, -13.91 -54.86, -39.45 APE12-dist-in 10.4537 APE11-dist-in 11.8359 APE10-dist-in 6.49 APE9-dist-in 3.958 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.73 0.19 0.227 A 304.0 291.0 6 30 26 4 [[183, 456]] 1.0 9na5 Homo sapiens TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 9NA5B Q9NWZ3 165 458 460.0 A1BWY:501 Type1 Inactive DFGin 6.876 13.9226 BLAminus -130.74, 172.07 71.17, 82.18 -107.01, 16.94 308.3, 95.76 -65.86, -22.74 in-out in 8.8818 Saltbr-out 4.1971 HRD-in -71.92, -49.38 75.44, -3.18 out-in-in SNCoii in-in ActLoopNT-in 2.6831 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.98, 162.05 APE9-dihe-na 124.64, -175.69 APE8-dihe-in -110.28, 114.32 APE8-rot-in 308.49 APE67-dihe-in -65.45, -14.65 -45.32, -47.37 APE12-dist-in 10.2616 APE11-dist-in 12.1034 APE10-dist-in 6.6156 APE9-dist-in 4.2001 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.73 0.19 0.227 B 304.0 284.0 10 30 26 4 [[183, 456]] 1.0 9na5 Homo sapiens TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 9NA5C Q9NWZ3 161 458 460.0 A1BWY:501 Type1 Inactive DFGin 6.8473 13.8139 BLAminus -130.66, 174.72 69.96, 81.61 -104.57, 15.46 307.74, 101.68 -63.81, -23.82 in-out in 8.9007 Saltbr-out 5.866 HRD-in -74.06, -49.12 75.91, 0.34 out-in-in SNCoii in-in ActLoopNT-in 2.6928 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.19, 157.89 APE9-dihe-na 134.71, -176.93 APE8-dihe-in -111.25, 115.39 APE8-rot-in 313.06 APE67-dihe-in -67.61, -11.6 -53.8, -44.56 APE12-dist-in 10.3174 APE11-dist-in 11.8345 APE10-dist-in 6.4403 APE9-dist-in 4.0253 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.73 0.19 0.227 C 304.0 291.0 7 30 25 5 [[183, 456]] 1.0 9na5 Homo sapiens TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 9NA5D Q9NWZ3 164 458 460.0 A1BWY:501 Type1 Inactive DFGin 6.9561 13.9047 BLAminus -133.93, 172.24 67.87, 81.49 -104.77, 16.45 307.07, 100.09 -65.52, -27.63 in-out in 8.6953 Saltbr-out 4.3303 HRD-in -70.04, -49.46 77.38, -3.43 out-in-in SNCoii in-in ActLoopNT-in 2.7008 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.14, 158.61 APE9-dihe-na 129.07, -176.96 APE8-dihe-in -107.72, 113.83 APE8-rot-in 313.13 APE67-dihe-in -66.94, -16.69 -45.61, -45.94 APE12-dist-in 10.2273 APE11-dist-in 12.0281 APE10-dist-in 6.5641 APE9-dist-in 4.0674 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.73 0.19 0.227 D 304.0 285.0 10 30 26 4 [[183, 456]] 1.0 9na5 Homo sapiens TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 9NA6A Q9NWZ3 164 458 460.0 A1BWZ:501 Type1 Inactive DFGin 6.721 13.6876 BLAminus -137.72, 177.76 61.95, 81.18 -105.84, 21.75 314.25, 92.68 -68.32, -23.98 in-out in 8.8626 Saltbr-out 4.8157 HRD-in -69.93, -48.99 73.89, 7.21 out-in-in SNCoii in-in ActLoopNT-in 2.5351 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.84, 156.52 APE9-dihe-na 129.68, 177.66 APE8-dihe-in -93.15, 117.82 APE8-rot-in 311.66 APE67-dihe-in -64.52, -19.34 -62.24, -34.28 APE12-dist-in 10.4305 APE11-dist-in 11.758 APE10-dist-in 6.6341 APE9-dist-in 4.201 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.14 0.215 0.246 A 304.0 285.0 10 30 24 6 [[183, 456]] 1.0 9na6 Homo sapiens TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 9NA6B Q9NWZ3 166 458 460.0 A1BWZ:501 Type1 Inactive DFGin 6.8899 13.6553 BLAminus -131.83, -177.82 57.71, 78.74 -101.25, 28.45 309.13, 97.45 -66.82, -49.29 in-out in 8.7208 Saltbr-out 4.4197 HRD-in -71.05, -48.89 69.34, 8.62 out-in-in SNCoii in-in ActLoopNT-in 2.4766 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.78, 144.51 APE9-dihe-na 141.43, -168.74 APE8-dihe-in -110.53, 118.7 APE8-rot-in 308.86 APE67-dihe-in -63.4, -17.18 -58.15, -40.7 APE12-dist-in 10.2018 APE11-dist-in 11.9098 APE10-dist-in 6.4955 APE9-dist-in 4.2297 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.14 0.215 0.246 B 304.0 276.0 17 30 25 5 [[183, 456]] 1.0 9na6 Homo sapiens TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 9NA6C Q9NWZ3 165 458 460.0 A1BWZ:501 Type1 Inactive DFGin 6.8296 13.8219 BLAminus -137.21, 175.52 61.39, 85.88 -109.71, 19.68 311.56, 94.94 -67.31, -23.31 in-out in 8.9623 Saltbr-out 4.2037 HRD-in -70.95, -51.5 74.46, 4.63 out-in-in SNCoii in-in ActLoopNT-in 2.6532 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.0, 159.33 APE9-dihe-na 132.78, -176.71 APE8-dihe-in -104.67, 119.95 APE8-rot-in 309.79 APE67-dihe-in -64.37, -16.17 -62.59, -40.04 APE12-dist-in 10.1583 APE11-dist-in 11.6635 APE10-dist-in 6.4426 APE9-dist-in 4.1281 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.14 0.215 0.246 C 304.0 286.0 8 30 25 5 [[183, 456]] 1.0 9na6 Homo sapiens TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 9NA6D Q9NWZ3 165 458 460.0 A1BWZ:501 Type1 Inactive DFGin 6.9431 13.6177 BLAminus -133.67, 176.88 60.25, 73.83 -97.87, 24.38 314.47, 96.87 -71.99, -35.94 in-out in 8.7921 Saltbr-out 5.2844 HRD-in -66.69, -50.31 69.34, 8.63 out-in-in SNCoii in-in ActLoopNT-in 2.6485 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.39, 147.5 APE9-dihe-na 142.28, -170.25 APE8-dihe-in -108.07, 118.9 APE8-rot-in 310.29 APE67-dihe-in -66.51, -20.67 -56.64, -38.87 APE12-dist-in 10.1932 APE11-dist-in 11.7368 APE10-dist-in 6.4753 APE9-dist-in 4.3319 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.14 0.215 0.246 D 304.0 277.0 17 30 26 4 [[183, 456]] 1.0 9na6 Homo sapiens TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6O8UA Q9NWZ3 164 458 460.0 LS7:501 Type1 Inactive DFGin 6.8496 13.9237 BLAminus -130.69, 173.07 63.01, 86.37 -108.36, 22.19 311.43, 95.51 -64.92, -32.76 in-out in 8.7449 Saltbr-out 5.5857 HRD-in -75.11, -49.45 74.88, -0.72 out-in-in SNCoii in-in ActLoopNT-in 2.8137 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.91, 157.66 APE9-dihe-na 128.13, 175.66 APE8-dihe-in -101.58, 115.34 APE8-rot-in 306.32 APE67-dihe-in -62.48, -19.12 -53.1, -39.45 APE12-dist-in 10.265 APE11-dist-in 11.8986 APE10-dist-in 6.3917 APE9-dist-in 3.9382 None TPO345,SEP346 TPO345,SEP346 XRAY 1.8 0.232 0.255 A 305.0 283.0 12 30 24 6 [[183, 456]] 1.0 6o8u Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6O8UB Q9NWZ3 160 458 460.0 LS7:501 Type1 Inactive DFGin 6.7464 14.3255 BLAminus -126.54, 176.56 64.22, 88.45 -115.23, 24.91 305.83, 84.08 -70.08, -44.03 in-out in 8.8874 Saltbr-out 4.6625 HRD-in -67.93, -50.14 73.94, 8.33 out-in-in SNCoii in-in ActLoopNT-in 2.8827 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.94, 156.88 APE9-dihe-na 130.39, -170.17 APE8-dihe-in -111.3, 117.6 APE8-rot-in 309.78 APE67-dihe-in -67.89, -15.82 -48.54, -45.93 APE12-dist-in 10.4025 APE11-dist-in 11.9103 APE10-dist-in 6.5663 APE9-dist-in 4.1608 None TPO345,SEP346 TPO345,SEP346 XRAY 1.8 0.232 0.255 B 305.0 286.0 13 30 23 7 [[183, 456]] 1.0 6o8u Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6O8UC Q9NWZ3 163 458 460.0 LS7:501 Type1 Inactive DFGin 6.7864 13.9031 BLAminus -128.29, 176.07 64.24, 85.11 -109.32, 20.81 312.79, 96.26 -63.76, -35.39 in-out in 8.9621 Saltbr-out 5.2152 HRD-in -75.57, -52.02 75.43, 8.91 out-in-in SNCoii in-in ActLoopNT-in 2.8058 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.09, 151.89 APE9-dihe-na 134.27, -175.85 APE8-dihe-in -100.31, 112.85 APE8-rot-in 307.74 APE67-dihe-in -64.12, -18.09 -55.7, -37.12 APE12-dist-in 9.9208 APE11-dist-in 12.0749 APE10-dist-in 7.1277 APE9-dist-in 4.8131 None TPO345,SEP346 TPO345,SEP346 XRAY 1.8 0.232 0.255 C 305.0 292.0 4 30 26 4 [[183, 456]] 1.0 6o8u Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6O8UD Q9NWZ3 162 458 460.0 LS7:501 Type1 Inactive DFGin 6.6865 13.956 BLAminus -123.57, 176.25 66.06, 85.61 -109.09, 18.14 308.14, 93.15 -62.5, -37.48 in-out in 9.0392 Saltbr-out 4.9797 HRD-in -73.18, -49.75 72.94, 10.03 out-in-in SNCoii in-in ActLoopNT-in 2.8474 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.37, 151.31 APE9-dihe-na 137.68, -175.61 APE8-dihe-in -104.71, 113.88 APE8-rot-in 306.99 APE67-dihe-in -63.19, -22.97 -60.18, -27.94 APE12-dist-in 9.9588 APE11-dist-in 11.8343 APE10-dist-in 6.9077 APE9-dist-in 4.6584 None TPO345,SEP346 TPO345,SEP346 XRAY 1.8 0.232 0.255 D 305.0 290.0 7 30 24 6 [[183, 456]] 1.0 6o8u Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5W85A Q9NWZ3 164 458 460.0 9YS:4000 Type1 Inactive DFGin 6.813 14.8006 BLAminus -119.69, 174.7 62.24, 92.17 -111.46, 11.32 305.63, 96.72 -63.25, -31.58 in-out in 8.9015 Saltbr-out 6.0751 HRD-in -63.97, -52.63 78.83, -4.43 out-in-in SNCoii in-in ActLoopNT-in 2.712 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.53, 155.64 APE9-dihe-na 132.02, -173.09 APE8-dihe-in -113.06, 114.4 APE8-rot-in 314.94 APE67-dihe-in -58.27, -22.42 -43.08, -51.51 APE12-dist-in 10.7433 APE11-dist-in 11.6775 APE10-dist-in 6.2108 APE9-dist-in 3.7715 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.25 0.227 0.251 A 305.0 281.0 14 30 25 5 [[183, 456]] 1.0 5w85 Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5W85B Q9NWZ3 164 459 460.0 9YS:4000 Type1 Inactive DFGin 6.7637 14.8223 BLAminus -118.77, 174.95 63.48, 91.76 -111.27, 11.84 305.7, 96.65 -62.41, -32.37 in-out in 8.9394 Saltbr-out 6.4178 HRD-in -63.31, -52.79 78.17, -3.31 out-in-in SNCoii in-in ActLoopNT-in 2.711 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.8, 156.56 APE9-dihe-na 131.61, -171.93 APE8-dihe-in -111.44, 113.82 APE8-rot-in 314.64 APE67-dihe-in -58.18, -22.16 -43.05, -51.43 APE12-dist-in 10.6394 APE11-dist-in 11.7542 APE10-dist-in 6.2542 APE9-dist-in 3.7207 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.25 0.227 0.251 B 305.0 282.0 14 30 26 4 [[183, 456]] 1.0 5w85 Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6LXYA Q9NWZ3 163 458 460.0 EXF:501 Type1 Inactive DFGin 6.9967 14.0491 BLAminus -130.85, 177.02 62.25, 85.69 -105.57, 13.21 307.3, 97.03 -58.17, -30.36 in-out in 8.9293 Saltbr-out 5.3622 HRD-in -67.47, -54.1 77.02, 0.48 out-in-in SNCoii in-in ActLoopNT-in 2.8192 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.95, 147.66 APE9-dihe-na 135.07, -175.38 APE8-dihe-in -106.14, 112.07 APE8-rot-in 312.29 APE67-dihe-in -59.29, -20.88 -52.35, -43.4 APE12-dist-in 10.1915 APE11-dist-in 11.7043 APE10-dist-in 6.4389 APE9-dist-in 4.3573 None TPO345,SEP346 TPO345,SEP346 XRAY 2.19 0.202 0.231 A 305.0 294.0 2 30 28 2 [[183, 456]] 1.0 6lxy Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6LXYD Q9NWZ3 162 459 460.0 EXF:502 Type1 Inactive DFGin 7.0024 14.1156 BLAminus -130.62, 177.55 62.4, 85.91 -106.35, 12.8 307.19, 98.16 -58.64, -30.18 in-out in 8.9428 Saltbr-out 5.3537 HRD-in -67.38, -53.42 77.14, -1.48 out-in-in SNCoii in-in ActLoopNT-in 2.7863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.01, 149.8 APE9-dihe-na 134.89, -175.28 APE8-dihe-in -104.95, 111.45 APE8-rot-in 311.34 APE67-dihe-in -58.57, -21.72 -44.58, -48.25 APE12-dist-in 10.314 APE11-dist-in 11.9545 APE10-dist-in 6.613 APE9-dist-in 4.2536 None TPO345,SEP346 TPO345,SEP346 XRAY 2.19 0.202 0.231 D 305.0 293.0 5 30 25 5 [[183, 456]] 1.0 6lxy Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6LXYE Q9NWZ3 164 458 460.0 EXF:502 Type1 Inactive DFGin 6.9536 14.1587 BLAminus -130.3, 176.57 62.62, 85.73 -105.89, 13.23 306.79, 97.59 -58.45, -29.69 in-out in 8.9309 Saltbr-out 5.3907 HRD-in -66.96, -52.89 76.03, -0.37 out-in-in SNCoii in-in ActLoopNT-in 2.7953 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.25, 150.73 APE9-dihe-na 134.77, -173.9 APE8-dihe-in -105.72, 111.9 APE8-rot-in 311.85 APE67-dihe-in -56.93, -22.86 -45.56, -48.25 APE12-dist-in 10.3091 APE11-dist-in 11.9048 APE10-dist-in 6.6072 APE9-dist-in 4.2918 None TPO345,SEP346 TPO345,SEP346 XRAY 2.19 0.202 0.231 E 305.0 288.0 7 30 23 7 [[183, 456]] 1.0 6lxy Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6VQLA Q9NWZ3 162 458 460.0 R7S:501 Type1 Inactive DFGin 6.9484 14.1016 BLAminus -128.89, 178.86 62.54, 89.32 -112.77, 19.41 307.7, 95.35 -67.01, -28.48 in-out in 8.8675 Saltbr-out 5.76 HRD-in -60.86, -51.23 73.74, 13.24 out-in-in SNCoii in-in ActLoopNT-in 2.8492 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.6, 156.29 APE9-dihe-na 133.29, -167.61 APE8-dihe-in -110.06, 117.8 APE8-rot-in 304.32 APE67-dihe-in -57.05, -22.07 -48.75, -46.61 APE12-dist-in 10.1761 APE11-dist-in 11.8072 APE10-dist-in 6.649 APE9-dist-in 4.2808 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.069 0.244 0.279 A 305.0 289.0 8 30 24 6 [[183, 456]] 1.0 6vql Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6VQLB Q9NWZ3 163 458 460.0 R7S:501 Type1 Inactive DFGin 6.8966 14.2148 BLAminus -126.69, 171.91 63.96, 89.58 -112.73, 19.19 306.74, 94.98 -66.69, -28.16 in-out in 8.9822 Saltbr-out 5.741 HRD-in -62.48, -51.55 75.13, -0.71 out-in-in SNCoii in-in ActLoopNT-in 2.8406 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.85, 155.05 APE9-dihe-na 137.23, -167.23 APE8-dihe-in -108.71, 118.9 APE8-rot-in 303.04 APE67-dihe-in -58.51, -22.41 -49.11, -44.93 APE12-dist-in 9.9848 APE11-dist-in 11.6612 APE10-dist-in 6.4733 APE9-dist-in 4.1617 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.069 0.244 0.279 B 305.0 286.0 10 30 24 6 [[183, 456]] 1.0 6vql Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6VQLC Q9NWZ3 163 458 460.0 R7S:501 Type1 Inactive DFGin 6.8553 14.2188 BLAminus -132.18, 176.88 62.56, 88.49 -111.96, 18.83 307.92, 94.58 -68.15, -27.83 in-out in 8.914 Saltbr-out 5.6384 HRD-in -60.2, -52.63 76.62, 2.47 out-in-in SNCoii in-in ActLoopNT-in 2.8512 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.63, 152.97 APE9-dihe-na 134.77, -170.05 APE8-dihe-in -109.39, 118.28 APE8-rot-in 304.2 APE67-dihe-in -58.39, -21.83 -47.95, -45.47 APE12-dist-in 10.3271 APE11-dist-in 11.87 APE10-dist-in 6.6051 APE9-dist-in 4.1155 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.069 0.244 0.279 C 305.0 287.0 9 30 26 4 [[183, 456]] 1.0 6vql Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6VQLD Q9NWZ3 164 458 460.0 R7S:501 Type1 Inactive DFGin 6.8992 14.2157 BLAminus -132.06, 177.07 63.58, 87.81 -112.09, 19.53 307.29, 95.54 -67.51, -28.65 in-out in 8.8824 Saltbr-out 5.7951 HRD-in -61.98, -52.71 76.16, 3.96 out-in-in SNCoii in-in ActLoopNT-in 2.8477 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.0, 154.7 APE9-dihe-na 133.81, -169.11 APE8-dihe-in -109.98, 117.79 APE8-rot-in 303.11 APE67-dihe-in -57.87, -22.08 -46.74, -46.13 APE12-dist-in 10.0605 APE11-dist-in 11.8494 APE10-dist-in 6.607 APE9-dist-in 4.1195 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.069 0.244 0.279 D 305.0 287.0 8 30 27 3 [[183, 456]] 1.0 6vql Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8SCEA Q9NWZ3 164 459 460.0 ZVD:501 Type1 Inactive DFGin 6.8097 14.0165 BLAminus -126.47, -178.7 59.91, 82.58 -102.13, 13.59 306.65, 101.09 -59.02, -31.96 in-out in 8.9343 Saltbr-out 3.9405 HRD-in -69.45, -51.74 77.12, -3.19 out-in-in SNCoii in-in ActLoopNT-in 2.7833 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.78, 152.45 APE9-dihe-na 139.2, -169.88 APE8-dihe-in -111.37, 109.73 APE8-rot-in 310.53 APE67-dihe-in -61.52, -17.0 -52.93, -40.4 APE12-dist-in 10.3682 APE11-dist-in 11.7487 APE10-dist-in 6.5372 APE9-dist-in 4.2328 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.89 0.204 0.228 A 305.0 286.0 10 30 25 5 [[183, 456]] 1.0 8sce Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8SCVB Q9NWZ3 165 459 460.0 ZVG:501 Type1 Inactive DFGin 7.1982 14.2281 BLAminus -124.98, -179.77 59.41, 86.09 -112.04, 18.78 306.72, 95.85 -65.24, -40.99 in-none in 8.6641 Saltbr-none 999.0 HRD-in -71.15, -45.18 73.66, -10.79 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aannn APEdist_ooon APE10-dihe-na -17.19, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -60.41, -44.69 999.0, 171.91 APE12-dist-out 20.2582 APE11-dist-out 21.893 APE10-dist-out 16.6393 APE9-dist-none 999.0 None TPO345,SEP346 TPO345,SEP346 XRAY 2.69 0.222 0.261 B 305.0 263.0 32 30 19 11 [[183, 456]] 1.0 8scv Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 2NRUA Q9NWZ3 164 458 460.0 T12:600 Type1 Inactive DFGin 6.8099 14.2068 BLAminus -144.52, 176.61 61.01, 85.78 -109.02, 12.36 305.24, 99.64 -69.12, -13.83 in-out in 8.9452 Saltbr-out 4.7125 HRD-in -72.42, -46.16 74.2, -6.12 out-in-in SNCoii in-in ActLoopNT-in 2.7294 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.65, 155.19 APE9-dihe-na 137.29, -171.31 APE8-dihe-in -118.15, 118.79 APE8-rot-in 298.95 APE67-dihe-in -68.17, -16.18 -56.18, -39.45 APE12-dist-in 9.9818 APE11-dist-in 12.0247 APE10-dist-in 6.3558 APE9-dist-in 3.6872 None TPO345,SEP346 TPO345,SEP346 XRAY 2.0 0.237 0.299 A 307.0 295.0 0 30 30 0 [[183, 456]] 1.0 2nru Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 2NRUB Q9NWZ3 163 458 460.0 T12:601 Type1 Inactive DFGin 6.9604 14.2106 BLAminus -137.22, 177.45 63.67, 76.5 -99.31, 24.17 313.64, 91.89 -66.38, -18.79 in-out in 8.9606 Saltbr-out 4.8485 HRD-in -79.32, -50.69 82.23, -1.29 out-in-in SNCoii in-in ActLoopNT-in 2.7826 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.97, 154.3 APE9-dihe-na 141.66, -169.29 APE8-dihe-in -112.44, 117.57 APE8-rot-in 305.42 APE67-dihe-in -56.19, -21.78 -44.47, -53.99 APE12-dist-in 10.0872 APE11-dist-in 11.8736 APE10-dist-in 6.2572 APE9-dist-in 3.7879 None TPO345,SEP346 TPO345,SEP346 XRAY 2.0 0.237 0.299 B 307.0 296.0 0 30 30 0 [[183, 456]] 1.0 2nru Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 2NRUC Q9NWZ3 164 458 460.0 T12:602 Type1 Inactive DFGin 6.8622 14.0444 BLAminus -133.27, -178.43 54.04, 81.31 -99.32, 21.09 309.78, 92.94 -44.33, -46.49 in-out in 9.1783 Saltbr-out 6.0489 HRD-in -65.42, -50.47 80.21, -0.92 out-in-in SNCoii in-in ActLoopNT-in 2.6841 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.9, 149.98 APE9-dihe-na 140.03, -170.94 APE8-dihe-in -117.58, 117.62 APE8-rot-in 307.34 APE67-dihe-in -53.9, -13.95 -48.73, -50.48 APE12-dist-in 9.9887 APE11-dist-in 11.9789 APE10-dist-in 6.1763 APE9-dist-in 3.6513 None TPO345,SEP346 TPO345,SEP346 XRAY 2.0 0.237 0.299 C 307.0 295.0 0 30 30 0 [[183, 456]] 1.0 2nru Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 2NRUD Q9NWZ3 164 458 460.0 T12:603 Type1 Inactive DFGin 6.9472 14.0982 BLAminus -135.72, 173.17 70.19, 87.19 -107.97, 13.86 307.81, 96.43 -64.39, -20.58 in-out in 9.1072 Saltbr-out 4.4888 HRD-in -69.73, -51.3 77.25, -2.09 out-in-in SNCoii in-in ActLoopNT-in 2.6621 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.08, 159.59 APE9-dihe-na 136.7, -170.84 APE8-dihe-in -116.97, 119.52 APE8-rot-in 299.39 APE67-dihe-in -65.53, -15.07 -56.41, -37.98 APE12-dist-in 9.9199 APE11-dist-in 11.8549 APE10-dist-in 6.2692 APE9-dist-in 3.6063 None TPO345,SEP346 TPO345,SEP346 XRAY 2.0 0.237 0.299 D 307.0 295.0 0 30 30 0 [[183, 456]] 1.0 2nru Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4RMZA Q9NWZ3 165 458 460.0 T20:501 Type1 Inactive DFGin 6.9177 13.9891 BLAminus -126.68, 170.9 71.61, 84.5 -108.32, 13.5 307.27, 99.22 -63.08, -23.58 in-out in 9.2564 Saltbr-out 5.0284 HRD-in -71.37, -54.68 82.53, 0.08 out-in-in SNCoii in-in ActLoopNT-in 2.6851 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.07, 154.46 APE9-dihe-na 140.89, -175.55 APE8-dihe-in -107.53, 124.9 APE8-rot-in 311.29 APE67-dihe-in -64.19, -16.01 -66.65, -36.99 APE12-dist-in 10.1681 APE11-dist-in 11.8109 APE10-dist-in 6.8502 APE9-dist-in 3.935 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.2 0.239 0.296 A 307.0 287.0 7 30 27 3 [[183, 456]] 1.0 4rmz Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4RMZB Q9NWZ3 165 458 460.0 T20:501 Type1 Inactive DFGin 6.6818 13.8372 BLAminus -127.34, 178.11 67.71, 81.3 -107.41, 14.46 311.78, 87.68 -59.65, -35.76 in-out in 9.1851 Saltbr-out 4.3576 HRD-in -77.65, -51.27 81.38, -11.53 out-in-in SNCoii in-in ActLoopNT-in 2.8032 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.02, 148.94 APE9-dihe-na 142.43, 179.5 APE8-dihe-in -98.65, 120.34 APE8-rot-in 323.49 APE67-dihe-in -67.37, -15.66 -55.22, -41.75 APE12-dist-in 10.2326 APE11-dist-in 12.0489 APE10-dist-in 6.7697 APE9-dist-in 4.476 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.2 0.239 0.296 B 307.0 284.0 10 30 24 6 [[183, 456]] 1.0 4rmz Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8TVMA Q9NWZ3 164 459 460.0 VDC:501 Type1 Inactive DFGin 7.0501 14.4498 BLAminus -132.18, 174.07 62.0, 72.94 -94.59, 26.48 308.28, 71.42 -66.42, -36.15 in-out in 9.0051 Saltbr-out 4.39 HRD-in -66.24, -53.38 76.43, -3.48 out-in-in SNCoii in-in ActLoopNT-in 2.6755 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.69, 149.04 APE9-dihe-na 147.68, -173.36 APE8-dihe-in -109.64, 107.78 APE8-rot-in 317.11 APE67-dihe-in -64.75, -17.49 -53.67, -37.13 APE12-dist-in 9.854 APE11-dist-in 11.9108 APE10-dist-in 6.7173 APE9-dist-in 4.1363 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.223 0.246 A 307.0 287.0 9 30 25 5 [[183, 456]] 1.0 8tvm Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8TVNB Q9NWZ3 164 459 460.0 VE9:501 Type1 Inactive DFGin 6.6028 14.4763 BLAminus -131.79, -173.84 61.55, 70.77 -94.0, 17.31 300.61, 97.59 -62.64, -29.8 in-out in 9.1406 Saltbr-out 4.7146 HRD-in -66.97, -49.93 68.76, 1.62 out-in-in SNCoii in-in ActLoopNT-in 2.9298 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.69, 158.15 APE9-dihe-na 141.52, -174.1 APE8-dihe-in -109.0, 120.89 APE8-rot-in 302.22 APE67-dihe-in -68.04, -9.84 -64.13, -33.08 APE12-dist-in 10.3621 APE11-dist-in 11.6165 APE10-dist-in 6.1182 APE9-dist-in 3.6145 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.95 0.208 0.242 B 307.0 286.0 10 30 24 6 [[183, 456]] 1.0 8tvn Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8TVNC Q9NWZ3 164 458 460.0 VE9:501 Type1 Inactive DFGin 6.8157 14.2711 BLAminus -134.87, -179.71 63.14, 78.0 -99.07, 16.75 311.05, 99.83 -68.52, -20.84 in-out in 8.9656 Saltbr-out 7.9858 HRD-in -73.64, -49.44 78.87, -3.37 out-in-in SNCoii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.92, 162.63 APE9-dihe-na 133.65, -178.49 APE8-dihe-in -106.73, 121.01 APE8-rot-in 304.08 APE67-dihe-in -68.08, -14.0 -59.46, -35.34 APE12-dist-in 10.0153 APE11-dist-in 11.7731 APE10-dist-in 6.3704 APE9-dist-in 3.7637 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.95 0.208 0.242 C 307.0 286.0 9 30 24 6 [[183, 456]] 1.0 8tvn Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8TX0A Q9NWZ3 164 459 460.0 VEU:501 Type1 Inactive DFGin 6.7893 13.9204 BLAminus -129.73, 176.59 65.6, 77.23 -99.3, 19.02 315.24, 98.72 -60.81, -34.53 in-out in 8.826 Saltbr-out 5.8696 HRD-in -69.7, -48.85 75.81, -2.36 out-in-in SNCoii in-in ActLoopNT-in 2.6468 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.63, 157.0 APE9-dihe-na 131.18, -179.13 APE8-dihe-in -106.66, 116.14 APE8-rot-in 293.2 APE67-dihe-in -65.42, -13.38 -58.15, -40.41 APE12-dist-in 9.8637 APE11-dist-in 11.8077 APE10-dist-in 6.5529 APE9-dist-in 4.2168 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.0 0.208 0.238 A 307.0 286.0 10 30 25 5 [[183, 456]] 1.0 8tx0 Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8TX0B Q9NWZ3 164 459 460.0 VEU:501 Type1 Inactive DFGin 6.8379 14.2966 BLAminus -129.72, 178.54 65.66, 76.17 -98.39, 13.53 305.13, 94.22 -63.2, -26.14 in-out in 9.2869 Saltbr-out 4.5523 HRD-in -70.22, -48.33 73.47, 0.05 out-in-in SNCoii in-in ActLoopNT-in 2.7242 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.02, 152.76 APE9-dihe-na 138.77, -175.43 APE8-dihe-in -104.24, 111.09 APE8-rot-in 310.05 APE67-dihe-in -64.51, -18.26 -47.53, -45.01 APE12-dist-in 9.9994 APE11-dist-in 12.0054 APE10-dist-in 7.0902 APE9-dist-in 4.8138 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.0 0.208 0.238 B 307.0 292.0 4 30 26 4 [[183, 456]] 1.0 8tx0 Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8UCBA Q9NWZ3 164 459 460.0 X1T:501 Type1 Inactive DFGin 6.5864 13.5726 BLAminus -133.38, -177.12 64.35, 68.66 -97.8, 16.07 315.98, 102.93 -65.68, -24.73 in-out in 8.6022 Saltbr-out 4.6911 HRD-in -74.88, -51.2 76.87, -1.43 out-in-in SNCoii in-in ActLoopNT-in 2.7607 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.62, 153.75 APE9-dihe-na 131.02, 179.21 APE8-dihe-in -98.2, 123.02 APE8-rot-in 308.0 APE67-dihe-in -65.09, -13.5 -58.01, -44.66 APE12-dist-in 10.2847 APE11-dist-in 12.061 APE10-dist-in 6.9488 APE9-dist-in 4.5201 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.85 0.209 0.243 A 307.0 289.0 7 30 26 4 [[183, 456]] 1.0 8ucb Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8UCBB Q9NWZ3 164 459 460.0 X1T:501 Type1 Inactive DFGin 6.6068 13.6491 BLAminus -133.65, -177.71 64.73, 70.02 -96.46, 15.08 312.24, 106.62 -64.34, -23.76 in-out in 8.4707 Saltbr-out 4.4017 HRD-in -75.17, -52.58 77.06, -2.05 out-in-in SNCoii in-in ActLoopNT-in 2.7252 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.68, 152.68 APE9-dihe-na 139.38, -177.32 APE8-dihe-in -102.85, 112.84 APE8-rot-in 315.95 APE67-dihe-in -69.47, -15.98 -65.94, -25.77 APE12-dist-in 10.0344 APE11-dist-in 12.218 APE10-dist-in 7.2634 APE9-dist-in 4.5061 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.85 0.209 0.243 B 307.0 288.0 8 30 24 6 [[183, 456]] 1.0 8ucb Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8UCBC Q9NWZ3 164 459 460.0 X1T:501 Type1 Inactive DFGin 6.8619 13.6822 BLAminus -134.97, -176.91 65.3, 70.16 -98.18, 15.85 309.36, 103.91 -62.86, -30.38 in-out in 8.58 Saltbr-out 4.6734 HRD-in -73.7, -52.09 76.17, -2.4 out-in-in SNCoii in-in ActLoopNT-in 2.7491 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.82, 155.19 APE9-dihe-na 136.02, -175.98 APE8-dihe-in -107.53, 111.71 APE8-rot-in 310.29 APE67-dihe-in -67.32, -13.57 -61.09, -32.68 APE12-dist-in 10.0286 APE11-dist-in 11.8791 APE10-dist-in 6.6271 APE9-dist-in 4.3453 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.85 0.209 0.243 C 307.0 287.0 9 30 24 6 [[183, 456]] 1.0 8ucb Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8UCBD Q9NWZ3 163 459 460.0 X1T:501 Type1 Inactive DFGin 6.6554 13.7707 BLAminus -133.17, -176.75 64.27, 71.56 -97.28, 15.93 311.73, 106.12 -63.94, -30.66 in-out in 8.6256 Saltbr-out 4.5655 HRD-in -70.95, -49.5 72.68, -1.18 out-in-in SNCoii in-in ActLoopNT-in 2.6741 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.88, 149.05 APE9-dihe-na 123.76, 174.28 APE8-dihe-in -91.74, 123.53 APE8-rot-in 308.1 APE67-dihe-in -62.24, -18.02 -60.37, -40.94 APE12-dist-in 10.2039 APE11-dist-in 11.968 APE10-dist-in 6.4738 APE9-dist-in 4.435 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.85 0.209 0.243 D 307.0 291.0 6 30 25 5 [[183, 456]] 1.0 8ucb Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8UCCA Q9NWZ3 160 459 460.0 WFQ:501 Type1 Inactive DFGin 7.0259 14.6998 BLAminus -131.7, 179.12 66.11, 75.99 -100.65, 16.62 301.91, 97.83 -63.53, -20.26 in-out in 9.3909 Saltbr-out 5.6136 HRD-in -75.53, -47.51 77.1, -4.78 out-in-in SNCoii in-in ActLoopNT-in 2.6824 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.27, 158.69 APE9-dihe-na 128.46, -168.51 APE8-dihe-in -116.14, 113.09 APE8-rot-in 308.41 APE67-dihe-in -66.69, -15.41 -48.67, -44.93 APE12-dist-in 10.0268 APE11-dist-in 11.9409 APE10-dist-in 6.614 APE9-dist-in 4.0809 None TPO345,SEP346 TPO345,SEP346 XRAY 1.8 0.21 0.24 A 307.0 295.0 5 30 25 5 [[183, 456]] 1.0 8ucc Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8UCCB Q9NWZ3 164 458 460.0 WFQ:501 Type1 Inactive DFGin 6.8793 13.8721 BLAminus -129.51, 162.92 70.33, 79.94 -104.55, 23.09 318.21, 95.61 -62.87, -26.0 in-out in 8.7684 Saltbr-out 6.0166 HRD-in -75.0, -48.09 77.72, -4.06 out-in-in SNCoii in-in ActLoopNT-in 2.7395 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.42, 156.86 APE9-dihe-na 134.29, 179.4 APE8-dihe-in -111.9, 115.53 APE8-rot-in 300.81 APE67-dihe-in -63.49, -15.46 -50.92, -46.75 APE12-dist-in 9.9358 APE11-dist-in 11.9321 APE10-dist-in 6.4043 APE9-dist-in 3.8041 None TPO345 TPO345 XRAY 1.8 0.21 0.24 B 307.0 286.0 9 30 25 5 [[183, 456]] 1.0 8ucc Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6THWA Q9NWZ3 164 458 460.0 NBK:501 Type1 Inactive DFGin 6.8204 14.6137 BLAminus -123.66, 168.11 62.81, 82.82 -101.09, 19.87 307.94, 110.85 -62.52, -25.01 in-out in 9.344 Saltbr-out 4.8967 HRD-in -67.46, -50.06 75.47, -3.2 out-in-none SNCoin in-none ActLoopNT-in 2.7816 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -124.8, 166.47 APE9-dihe-na 126.73, -169.13 APE8-dihe-in -110.99, 111.83 APE8-rot-in 308.93 APE67-dihe-in -62.57, -16.11 -43.52, -47.59 APE12-dist-none 999.0 APE11-dist-in 11.9165 APE10-dist-in 6.5636 APE9-dist-in 3.7607 None None None XRAY 2.44 0.242 0.271 A 308.0 277.0 18 30 18 12 [[183, 456]] 1.0 6thw Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6THWB Q9NWZ3 164 458 460.0 NBK:501 Type1 Inactive DFGin 7.0858 14.4327 BLAminus -140.9, 170.15 72.18, 81.33 -104.48, 18.05 307.7, 105.04 -67.72, -34.78 in-out in 9.1622 Saltbr-out 6.8487 HRD-in -62.52, -55.9 78.39, -2.11 out-in-none SNCoin in-none ActLoopNT-in 2.6548 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -148.04, 150.43 APE9-dihe-na 154.2, -168.3 APE8-dihe-in -105.53, 110.29 APE8-rot-in 314.35 APE67-dihe-in -55.79, -22.17 -55.77, -37.55 APE12-dist-none 999.0 APE11-dist-in 11.5075 APE10-dist-in 6.9992 APE9-dist-in 4.133 None None None XRAY 2.44 0.242 0.271 B 308.0 281.0 14 30 19 11 [[183, 456]] 1.0 6thw Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6THXB Q9NWZ3 164 458 460.0 N9Z:501 Type1 Inactive DFGin 6.7832 14.5032 BLAminus -130.3, 173.53 69.43, 82.81 -102.19, 17.11 308.42, 101.98 -60.44, -37.77 in-out in 9.0557 Saltbr-out 6.7422 HRD-in -69.56, -52.62 80.33, -6.88 out-in-in SNCoii in-in ActLoopNT-in 2.7756 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.94, 145.34 APE9-dihe-na 147.73, -171.87 APE8-dihe-in -106.02, 110.0 APE8-rot-in 309.88 APE67-dihe-in -61.74, -18.4 -54.4, -36.6 APE12-dist-in 10.54 APE11-dist-in 11.7168 APE10-dist-in 6.4037 APE9-dist-in 4.1021 None TPO345,SEP346 TPO345,SEP346 XRAY 1.99 0.232 0.254 B 308.0 283.0 12 30 25 5 [[183, 456]] 1.0 6thx Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6THZB Q9NWZ3 164 458 460.0 NB5:501 Type1 Inactive DFGin 6.8838 14.4002 BLAminus -139.08, 176.87 64.46, 76.57 -96.2, 11.73 309.97, 94.63 -53.15, -40.13 in-out in 8.8775 Saltbr-out 7.0047 HRD-in -73.05, -47.74 74.11, -0.28 out-in-in SNCoii in-in ActLoopNT-in 2.79 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.96, 150.22 APE9-dihe-na 143.37, -165.81 APE8-dihe-in -109.46, 106.81 APE8-rot-in 312.76 APE67-dihe-in -65.57, -18.06 -35.96, -49.66 APE12-dist-in 10.5033 APE11-dist-in 11.8757 APE10-dist-in 6.7528 APE9-dist-in 4.1586 None TPO345,SEP346 TPO345,SEP346 XRAY 2.38 0.233 0.274 B 308.0 283.0 12 30 25 5 [[183, 456]] 1.0 6thz Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 7QG2A Q9NWZ3 164 458 460.0 B6I:501 Type1 Inactive DFGin 6.7297 14.1053 BLAminus -125.05, 176.88 61.14, 81.6 -102.86, 19.43 311.58, 97.65 -64.22, -24.25 in-out in 8.7049 Saltbr-out 4.5606 HRD-in -63.97, -47.98 75.86, -3.25 out-in-in SNCoii in-in ActLoopNT-in 2.8469 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.2, 151.19 APE9-dihe-na 136.66, 178.88 APE8-dihe-in -97.77, 114.51 APE8-rot-in 305.46 APE67-dihe-in -59.4, -19.06 -44.01, -48.1 APE12-dist-in 10.052 APE11-dist-in 11.4971 APE10-dist-in 6.1997 APE9-dist-in 3.9271 None TPO345,SEP346 TPO345,SEP346 XRAY 3.031 0.227 0.274 A 308.0 281.0 14 30 24 6 [[183, 456]] 1.0 7qg2 Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 7QG2B Q9NWZ3 165 458 460.0 B6I:501 Type1 Inactive DFGin 6.7217 14.5967 BLAminus -126.18, -179.5 55.73, 88.47 -114.93, 34.76 304.62, 86.87 -76.5, -21.59 in-out in 9.0083 Saltbr-out 4.1411 HRD-in -59.71, -48.0 76.59, -4.26 out-in-in SNCoii in-in ActLoopNT-in 2.8364 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.23, 151.56 APE9-dihe-na 136.82, 177.58 APE8-dihe-in -97.3, 113.73 APE8-rot-in 307.05 APE67-dihe-in -59.8, -18.2 -41.32, -48.97 APE12-dist-in 10.0594 APE11-dist-in 11.5265 APE10-dist-in 6.3643 APE9-dist-in 3.9131 None TPO345,SEP346 TPO345,SEP346 XRAY 3.031 0.227 0.274 B 308.0 275.0 19 30 22 8 [[183, 456]] 1.0 7qg2 Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 7QG2C Q9NWZ3 164 458 460.0 B6I:501 Type1 Inactive DFGin 6.9577 14.1725 BLAminus -123.88, 179.51 55.6, 95.37 -116.47, 22.24 302.05, 94.49 -66.41, -26.71 in-out in 8.9488 Saltbr-out 4.3168 HRD-in -60.39, -48.1 75.35, -2.7 out-in-in SNCoii in-in ActLoopNT-in 2.8488 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.09, 152.33 APE9-dihe-na 135.79, 177.88 APE8-dihe-in -96.73, 114.77 APE8-rot-in 307.98 APE67-dihe-in -59.31, -19.42 -43.08, -47.58 APE12-dist-in 10.1175 APE11-dist-in 11.6603 APE10-dist-in 6.4245 APE9-dist-in 3.9036 None TPO345,SEP346 TPO345,SEP346 XRAY 3.031 0.227 0.274 C 308.0 284.0 11 30 23 7 [[183, 456]] 1.0 7qg2 Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 7QG2D Q9NWZ3 164 458 460.0 B6I:501 Type1 Inactive DFGin 6.8695 14.5085 BLAminus -124.89, 178.48 57.48, 94.84 -118.64, 27.39 301.07, 100.0 -70.03, -20.47 in-out in 8.921 Saltbr-out 4.276 HRD-in -61.48, -47.48 76.38, -5.16 out-in-in SNCoii in-in ActLoopNT-in 2.8424 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.84, 151.37 APE9-dihe-na 137.51, 176.91 APE8-dihe-in -97.58, 114.3 APE8-rot-in 305.98 APE67-dihe-in -59.32, -18.8 -41.34, -49.0 APE12-dist-in 9.8967 APE11-dist-in 11.6128 APE10-dist-in 6.4087 APE9-dist-in 3.9216 None TPO345,SEP346 TPO345,SEP346 XRAY 3.031 0.227 0.274 D 308.0 280.0 15 30 23 7 [[183, 456]] 1.0 7qg2 Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 7QG3B Q9NWZ3 164 458 460.0 B4U:501 Type1 Inactive DFGin 6.8462 14.6838 BLAminus -132.44, 171.27 64.36, 88.43 -111.84, 26.31 313.62, 91.35 -71.36, -21.35 in-out in 8.677 Saltbr-out 5.0214 HRD-in -67.36, -50.82 78.83, -8.31 out-in-in SNCoii in-in ActLoopNT-in 2.7775 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.2, 142.27 APE9-dihe-na 152.04, -166.56 APE8-dihe-in -110.23, 113.93 APE8-rot-in 316.42 APE67-dihe-in -63.34, -18.6 -57.19, -37.15 APE12-dist-in 10.7684 APE11-dist-in 11.7378 APE10-dist-in 6.6852 APE9-dist-in 4.2629 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.11 0.273 0.304 B 308.0 283.0 12 30 24 6 [[183, 456]] 1.0 7qg3 Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 7QG5A Q9NWZ3 165 458 460.0 B7R:501 Type1 Inactive DFGin 6.578 14.4932 BLAminus -124.15, 174.43 61.08, 84.14 -101.81, 21.99 311.05, 99.37 -64.51, -29.58 in-out in 8.8835 Saltbr-out 3.9488 HRD-in -68.99, -49.5 76.63, -2.55 out-in-in SNCoii in-in ActLoopNT-in 2.8887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.94, 161.62 APE9-dihe-na 129.5, -173.09 APE8-dihe-in -108.69, 116.59 APE8-rot-in 312.95 APE67-dihe-in -65.31, -14.05 -47.57, -46.29 APE12-dist-in 9.9238 APE11-dist-in 11.7586 APE10-dist-in 6.4022 APE9-dist-in 3.9224 None TPO345,SEP346 TPO345,SEP346 XRAY 2.3 0.249 0.275 A 308.0 270.0 24 30 24 6 [[183, 456]] 1.0 7qg5 Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 7QG5B Q9NWZ3 164 458 460.0 B7R:501 Type1 Inactive DFGin 7.0578 14.3827 BLAminus -131.21, 172.38 65.67, 86.88 -104.52, 23.37 306.02, 106.65 -68.49, -29.45 in-out in 8.8038 Saltbr-out 3.9184 HRD-in -70.17, -49.03 75.63, -1.79 out-in-in SNCoii in-in ActLoopNT-in 2.8968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.87, 162.12 APE9-dihe-na 129.84, -172.51 APE8-dihe-in -109.04, 117.43 APE8-rot-in 313.01 APE67-dihe-in -64.34, -13.55 -51.38, -43.59 APE12-dist-in 10.0182 APE11-dist-in 11.6188 APE10-dist-in 6.3383 APE9-dist-in 3.9707 None TPO345,SEP346 TPO345,SEP346 XRAY 2.3 0.249 0.275 B 308.0 281.0 14 30 24 6 [[183, 456]] 1.0 7qg5 Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 9R9GA Q9NWZ3 163 458 460.0 Y9T:501 Type1 Inactive DFGin 6.948 14.2471 BLAminus -130.74, 175.0 63.76, 86.61 -108.65, 17.69 308.07, 98.94 -62.62, -29.22 in-out in 8.7339 Saltbr-out 4.8435 HRD-in -68.25, -50.26 77.88, -4.02 out-in-in SNCoii in-in ActLoopNT-in 2.8599 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.63, 160.85 APE9-dihe-na 132.15, -171.04 APE8-dihe-in -115.27, 115.04 APE8-rot-in 308.73 APE67-dihe-in -62.64, -15.32 -49.18, -44.92 APE12-dist-in 9.8967 APE11-dist-in 11.8568 APE10-dist-in 6.4089 APE9-dist-in 3.6889 None TPO345,SEP346 TPO345,SEP346 XRAY 1.88 0.204 0.228 A 308.0 286.0 10 30 25 5 [[183, 456]] 1.0 9r9g Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 9R9GB Q9NWZ3 163 458 460.0 Y9T:501 Type1 Inactive DFGin 6.9319 14.2655 BLAminus -125.04, 172.39 63.91, 85.11 -106.57, 17.26 306.3, 94.34 -62.58, -32.77 in-out in 8.6918 Saltbr-out 4.0108 HRD-in -67.99, -51.01 79.32, -6.48 out-in-in SNCoii in-in ActLoopNT-in 2.8491 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.63, 159.54 APE9-dihe-na 133.41, -171.38 APE8-dihe-in -115.54, 114.65 APE8-rot-in 308.5 APE67-dihe-in -62.16, -14.91 -45.99, -48.35 APE12-dist-in 9.9025 APE11-dist-in 11.9461 APE10-dist-in 6.482 APE9-dist-in 3.7204 None TPO345,SEP346 TPO345,SEP346 XRAY 1.88 0.204 0.228 B 308.0 286.0 10 30 25 5 [[183, 456]] 1.0 9r9g Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 9R9GC Q9NWZ3 164 458 460.0 Y9T:501 Type1 Inactive DFGin 7.0674 14.0996 BLAminus -129.01, 170.18 68.19, 86.48 -108.0, 15.16 307.09, 99.37 -62.89, -29.47 in-out in 8.5991 Saltbr-out 4.7702 HRD-in -67.95, -50.9 79.35, -5.74 out-in-in SNCoii in-in ActLoopNT-in 2.8497 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.34, 160.8 APE9-dihe-na 132.4, -171.76 APE8-dihe-in -114.85, 114.71 APE8-rot-in 307.49 APE67-dihe-in -61.59, -16.4 -48.9, -45.19 APE12-dist-in 9.893 APE11-dist-in 11.8233 APE10-dist-in 6.3745 APE9-dist-in 3.6951 None TPO345,SEP346 TPO345,SEP346 XRAY 1.88 0.204 0.228 C 308.0 286.0 9 30 25 5 [[183, 456]] 1.0 9r9g Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 9R9GD Q9NWZ3 164 458 460.0 Y9T:501 Type1 Inactive DFGin 7.0205 13.9212 BLAminus -128.78, 173.52 64.74, 84.24 -108.04, 17.03 309.57, 97.28 -63.17, -27.35 in-out in 8.6739 Saltbr-out 5.7794 HRD-in -67.79, -51.04 79.66, -6.4 out-in-in SNCoii in-in ActLoopNT-in 2.8362 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.94, 160.1 APE9-dihe-na 133.16, -172.19 APE8-dihe-in -114.51, 114.26 APE8-rot-in 307.76 APE67-dihe-in -62.14, -15.82 -42.97, -50.29 APE12-dist-in 9.8576 APE11-dist-in 11.8526 APE10-dist-in 6.3769 APE9-dist-in 3.6866 None TPO345,SEP346 TPO345,SEP346 XRAY 1.88 0.204 0.228 D 308.0 286.0 9 30 24 6 [[183, 456]] 1.0 9r9g Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 9R9KD Q9NWZ3 164 459 460.0 A1JDQ:501 Type1 Inactive DFGin 7.2627 13.9086 BLAminus -127.82, -173.62 51.62, 79.16 -94.28, 25.38 306.25, 90.36 -67.69, -32.97 in-out in 9.2191 Saltbr-out 3.6855 HRD-in -67.18, -49.93 79.82, -9.59 out-in-in SNCoii in-in ActLoopNT-in 2.8601 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.33, 161.69 APE9-dihe-na 131.99, -171.77 APE8-dihe-in -113.49, 115.43 APE8-rot-in 306.97 APE67-dihe-in -64.18, -12.29 -42.85, -50.18 APE12-dist-in 10.2285 APE11-dist-in 11.6612 APE10-dist-in 6.2577 APE9-dist-in 3.6952 None TPO345,SEP346 TPO345,SEP346 XRAY 1.87 0.216 0.242 D 308.0 287.0 9 30 25 5 [[183, 456]] 1.0 9r9k Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6O94A Q9NWZ3 163 458 460.0 LRS:502 Type1 Inactive DFGin 6.9797 13.9567 BLAminus -123.25, 179.18 58.62, 91.23 -110.31, 12.12 305.58, 96.78 -63.69, -27.63 in-out in 9.1142 Saltbr-out 5.0245 HRD-in -68.39, -52.68 75.29, -1.68 out-in-in SNCoii in-in ActLoopNT-in 2.8366 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.99, 140.47 APE9-dihe-na 148.46, -177.74 APE8-dihe-in -101.2, 107.55 APE8-rot-in 306.34 APE67-dihe-in -55.1, -20.47 -45.77, -47.94 APE12-dist-in 10.0718 APE11-dist-in 12.0661 APE10-dist-in 7.3254 APE9-dist-in 5.2183 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.98 0.184 0.215 A 320.0 292.0 4 30 26 4 [[183, 456]] 1.0 6o94 Homo sapiens TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6O94B Q9NWZ3 162 458 460.0 LRS:502 Type1 Inactive DFGin 6.899 14.0279 BLAminus -122.58, 179.95 63.12, 86.64 -108.65, 9.89 303.71, 93.33 -58.6, -27.16 in-out in 8.998 Saltbr-out 4.9134 HRD-in -65.66, -51.1 74.78, 1.16 out-in-in SNCoii in-in ActLoopNT-in 2.8194 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.21, 144.66 APE9-dihe-na 140.06, 177.25 APE8-dihe-in -95.53, 110.29 APE8-rot-in 309.4 APE67-dihe-in -63.88, -19.8 -59.96, -25.96 APE12-dist-in 10.2683 APE11-dist-in 12.0988 APE10-dist-in 7.0791 APE9-dist-in 4.8461 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.98 0.184 0.215 B 320.0 293.0 4 30 26 4 [[183, 456]] 1.0 6o94 Homo sapiens TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6O94C Q9NWZ3 163 458 460.0 LRS:501 Type1 Inactive DFGin 6.5899 14.128 BLAminus -121.22, 176.46 62.3, 93.01 -113.1, 16.55 308.78, 90.13 -63.81, -32.68 in-out in 8.6856 Saltbr-out 4.062 HRD-in -68.33, -51.83 77.7, -5.17 out-in-in SNCoii in-in ActLoopNT-in 2.7983 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.28, 149.13 APE9-dihe-na 136.69, -178.03 APE8-dihe-in -101.68, 113.37 APE8-rot-in 311.59 APE67-dihe-in -65.13, -21.18 -43.64, -46.59 APE12-dist-in 9.9441 APE11-dist-in 12.0198 APE10-dist-in 6.6751 APE9-dist-in 4.3492 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.98 0.184 0.215 C 320.0 286.0 10 30 26 4 [[183, 456]] 1.0 6o94 Homo sapiens TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6O94D Q9NWZ3 163 458 460.0 LRS:501 Type1 Inactive DFGin 7.0029 14.0207 BLAminus -126.53, 176.59 61.66, 94.12 -114.42, 13.3 307.72, 104.0 -58.57, -29.78 in-out in 8.9166 Saltbr-out 4.8918 HRD-in -70.14, -50.46 72.65, -1.5 out-in-in SNCoii in-in ActLoopNT-in 2.7844 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.81, 156.44 APE9-dihe-na 122.83, -176.0 APE8-dihe-in -107.14, 110.01 APE8-rot-in 318.74 APE67-dihe-in -57.74, -23.07 -42.07, -49.71 APE12-dist-in 10.2874 APE11-dist-in 12.0683 APE10-dist-in 6.673 APE9-dist-in 4.3687 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.98 0.184 0.215 D 320.0 285.0 11 30 25 5 [[183, 456]] 1.0 6o94 Homo sapiens TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6O95A Q9NWZ3 162 459 460.0 LSV:502 Type1 Inactive DFGin 6.5143 14.1644 BLAminus -124.69, 178.36 63.9, 85.02 -104.54, 7.03 304.14, 94.6 -57.19, -35.8 in-out in 8.8719 Saltbr-out 4.6326 HRD-in -66.91, -51.29 74.49, -0.76 out-in-in SNCoii in-in ActLoopNT-in 2.8041 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.02, 155.29 APE9-dihe-na 132.54, -175.83 APE8-dihe-in -104.27, 113.04 APE8-rot-in 302.9 APE67-dihe-in -57.84, -19.71 -40.16, -52.66 APE12-dist-in 10.0524 APE11-dist-in 12.0481 APE10-dist-in 6.8824 APE9-dist-in 4.3628 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.77 0.19 0.217 A 320.0 291.0 7 30 25 5 [[183, 456]] 1.0 6o95 Homo sapiens TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6O95B Q9NWZ3 163 458 460.0 LSV:501 Type1 Inactive DFGin 7.047 13.9336 BLAminus -128.69, 178.37 64.78, 86.4 -106.95, 10.27 304.55, 103.52 -56.04, -36.05 in-out in 8.6869 Saltbr-out 5.348 HRD-in -68.16, -49.56 73.95, -1.69 out-in-in SNCoii in-in ActLoopNT-in 2.8208 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.52, 156.12 APE9-dihe-na 128.25, -179.73 APE8-dihe-in -105.09, 111.99 APE8-rot-in 310.32 APE67-dihe-in -60.91, -16.95 -44.72, -45.17 APE12-dist-in 10.1353 APE11-dist-in 12.0602 APE10-dist-in 6.4328 APE9-dist-in 4.0004 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.77 0.19 0.217 B 320.0 279.0 17 30 25 5 [[183, 456]] 1.0 6o95 Homo sapiens TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6O95C Q9NWZ3 165 458 460.0 LSV:501 Type1 Inactive DFGin 6.9177 13.9296 BLAminus -128.33, 177.09 66.35, 90.72 -113.17, 15.76 309.56, 95.89 -60.57, -32.1 in-out in 8.9463 Saltbr-out 4.8251 HRD-in -67.67, -54.03 77.11, 0.43 out-in-in SNCoii in-in ActLoopNT-in 2.8077 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.77, 148.25 APE9-dihe-na 141.05, -171.27 APE8-dihe-in -106.42, 112.41 APE8-rot-in 303.07 APE67-dihe-in -59.27, -17.89 -44.67, -47.52 APE12-dist-in 10.0305 APE11-dist-in 12.0003 APE10-dist-in 7.1669 APE9-dist-in 4.8503 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.77 0.19 0.217 C 320.0 286.0 8 30 25 5 [[183, 456]] 1.0 6o95 Homo sapiens TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6O95D Q9NWZ3 161 458 460.0 LSV:503 Type1 Inactive DFGin 6.7141 13.781 BLAminus -126.14, -178.81 60.46, 90.73 -111.09, 9.64 304.76, 99.65 -59.01, -30.48 in-out in 8.9078 Saltbr-out 4.9695 HRD-in -67.54, -51.97 72.39, 2.38 out-in-in SNCoii in-in ActLoopNT-in 2.8137 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.99, 146.99 APE9-dihe-na 137.73, 178.81 APE8-dihe-in -100.23, 111.63 APE8-rot-in 301.88 APE67-dihe-in -63.03, -17.06 -59.78, -27.35 APE12-dist-in 10.1677 APE11-dist-in 11.9475 APE10-dist-in 6.7267 APE9-dist-in 4.7161 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.77 0.19 0.217 D 320.0 292.0 6 30 24 6 [[183, 456]] 1.0 6o95 Homo sapiens TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6O9DA Q9NWZ3 162 458 460.0 LTY:501 Type1 Inactive DFGin 6.7066 14.4556 BLAminus -127.76, -176.84 57.79, 87.99 -106.68, 3.04 297.04, 103.76 -53.04, -31.02 in-out in 8.3352 Saltbr-out 3.6179 HRD-in -61.91, -55.52 80.82, -6.22 out-in-in SNCoii in-in ActLoopNT-in 2.7956 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.17, 155.38 APE9-dihe-na 127.36, -176.8 APE8-dihe-in -102.61, 119.68 APE8-rot-in 323.19 APE67-dihe-in -59.01, -22.88 -47.44, -49.99 APE12-dist-in 9.9006 APE11-dist-in 11.5992 APE10-dist-in 6.2466 APE9-dist-in 3.9113 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.51 0.197 0.239 A 320.0 286.0 11 30 26 4 [[183, 456]] 1.0 6o9d Homo sapiens TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6O9DB Q9NWZ3 163 458 460.0 LTY:501 Type1 Inactive DFGin 7.0573 13.9514 BLAminus -143.03, -179.16 58.94, 82.95 -104.14, 17.08 307.96, 103.48 -62.26, -32.09 in-out in 8.6875 Saltbr-out 4.2071 HRD-in -62.85, -48.11 75.04, -10.08 out-in-in SNCoii in-in ActLoopNT-in 2.9311 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.13, 158.27 APE9-dihe-na 134.69, -173.08 APE8-dihe-in -118.39, 112.91 APE8-rot-in 312.26 APE67-dihe-in -64.54, -21.64 -47.5, -39.01 APE12-dist-in 10.1336 APE11-dist-in 11.7619 APE10-dist-in 6.3028 APE9-dist-in 4.0783 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.51 0.197 0.239 B 320.0 284.0 12 30 25 5 [[183, 456]] 1.0 6o9d Homo sapiens TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6O9DD Q9NWZ3 164 458 460.0 LTY:501 Type1 Inactive DFGin 6.8994 14.3177 BLAminus -134.66, 178.58 59.54, 82.94 -104.76, 14.4 302.36, 96.51 -59.1, -33.56 in-out in 8.7304 Saltbr-out 4.0778 HRD-in -68.8, -51.26 82.92, -3.16 out-in-in SNCoii in-in ActLoopNT-in 2.7865 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.38, 156.72 APE9-dihe-na 130.79, 174.85 APE8-dihe-in -97.61, 110.6 APE8-rot-in 318.14 APE67-dihe-in -67.31, -17.64 -49.18, -44.21 APE12-dist-in 10.2848 APE11-dist-in 11.7694 APE10-dist-in 6.4018 APE9-dist-in 4.2439 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.51 0.197 0.239 D 320.0 284.0 11 30 27 3 [[183, 456]] 1.0 6o9d Homo sapiens TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6UYAA Q9NWZ3 163 458 460.0 QL7:501 Type1 Inactive DFGin 6.9118 14.0613 BLAminus -130.83, 174.58 66.33, 88.53 -109.61, 11.93 305.77, 104.97 -60.29, -30.37 in-out in 8.9208 Saltbr-out 5.3891 HRD-in -66.32, -52.06 75.53, -1.71 out-in-in SNCoii in-in ActLoopNT-in 2.7571 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.77, 155.18 APE9-dihe-na 131.38, -176.71 APE8-dihe-in -108.73, 111.35 APE8-rot-in 311.67 APE67-dihe-in -54.65, -22.72 -39.48, -51.06 APE12-dist-in 10.4706 APE11-dist-in 12.0745 APE10-dist-in 6.6655 APE9-dist-in 4.1482 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.74 0.182 0.207 A 320.0 288.0 8 30 25 5 [[183, 456]] 1.0 6uya Homo sapiens TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6UYAB Q9NWZ3 165 458 460.0 QL7:502 Type1 Inactive DFGin 6.893 13.9843 BLAminus -128.71, 175.35 66.38, 92.59 -112.91, 7.52 303.04, 106.99 -58.83, -29.06 in-out in 9.0 Saltbr-out 5.0833 HRD-in -69.36, -50.91 73.85, 5.13 out-in-in SNCoii in-in ActLoopNT-in 2.8239 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.22, 142.0 APE9-dihe-na 152.09, 178.07 APE8-dihe-in -98.25, 109.05 APE8-rot-in 300.26 APE67-dihe-in -55.26, -18.41 -44.33, -48.88 APE12-dist-in 10.1551 APE11-dist-in 11.9953 APE10-dist-in 7.2576 APE9-dist-in 5.0479 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.74 0.182 0.207 B 320.0 290.0 4 30 26 4 [[183, 456]] 1.0 6uya Homo sapiens TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6UYAD Q9NWZ3 162 458 460.0 QL7:501 Type1 Inactive DFGin 6.8191 13.7579 BLAminus -128.37, 176.07 66.47, 90.2 -111.03, 7.65 306.44, 101.65 -54.58, -29.97 in-out in 8.9183 Saltbr-out 4.6606 HRD-in -66.75, -50.48 73.09, -0.55 out-in-in SNCoii in-in ActLoopNT-in 2.8044 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.42, 146.21 APE9-dihe-na 142.04, -178.31 APE8-dihe-in -100.42, 112.16 APE8-rot-in 302.67 APE67-dihe-in -61.72, -16.37 -57.08, -31.92 APE12-dist-in 10.0883 APE11-dist-in 11.9674 APE10-dist-in 6.9354 APE9-dist-in 4.7438 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.74 0.182 0.207 D 320.0 291.0 6 30 24 6 [[183, 456]] 1.0 6uya Homo sapiens TKL_IRAK4_HUMAN TKL 5.1e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6F3IA Q9NWZ3 165 458 460.0 CKN:501 Type1 Inactive DFGin 7.0541 14.3219 BLAminus -123.52, -179.8 60.09, 89.16 -112.89, 21.06 305.23, 95.52 -66.66, -30.45 in-out in 8.6589 Saltbr-out 8.1067 HRD-in -71.48, -51.41 77.44, -5.11 out-in-in SNCoii in-in ActLoopNT-in 2.7963 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.09, 147.59 APE9-dihe-na 131.67, -176.65 APE8-dihe-in -98.22, 114.27 APE8-rot-in 316.92 APE67-dihe-in -58.79, -21.5 -51.79, -39.53 APE12-dist-in 10.2249 APE11-dist-in 12.0072 APE10-dist-in 6.5371 APE9-dist-in 4.3271 None TPO345,SEP346 TPO345,SEP346 XRAY 2.14 0.237 0.27 A 322.0 260.0 34 30 23 7 [[183, 456]] 1.0 6f3i Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6F3IB Q9NWZ3 164 458 460.0 CKN:502 Type1 Inactive DFGin 7.0734 14.7278 BLAminus -124.14, 177.7 62.74, 84.47 -108.24, 21.83 305.38, 94.82 -65.48, -30.96 in-out in 9.2285 Saltbr-out 6.0168 HRD-in -71.3, -51.64 77.0, -4.42 out-in-in SNCoii in-in ActLoopNT-in 2.8027 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.51, 147.67 APE9-dihe-na 131.82, -176.31 APE8-dihe-in -97.78, 113.9 APE8-rot-in 318.2 APE67-dihe-in -58.63, -21.1 -51.98, -39.95 APE12-dist-in 10.2485 APE11-dist-in 11.8868 APE10-dist-in 6.4604 APE9-dist-in 4.3589 None TPO345,SEP346 TPO345,SEP346 XRAY 2.14 0.237 0.27 B 322.0 281.0 14 30 23 7 [[183, 456]] 1.0 6f3i Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6RFIA Q9NWZ3 165 458 460.0 K1H:502 Type1 Inactive DFGin 6.9898 14.3021 BLAminus -129.16, 176.7 63.09, 88.81 -109.76, 14.57 309.19, 95.71 -60.71, -34.41 in-out in 8.9539 Saltbr-out 4.6447 HRD-in -64.1, -51.33 77.3, -1.49 out-in-in SNCoii in-in ActLoopNT-in 2.9423 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.51, 158.58 APE9-dihe-na 128.54, -171.69 APE8-dihe-in -107.47, 116.44 APE8-rot-in 316.16 APE67-dihe-in -66.19, -16.15 -43.18, -47.25 APE12-dist-in 10.0116 APE11-dist-in 11.8198 APE10-dist-in 6.3514 APE9-dist-in 3.7063 None TPO345,SEP346 TPO345,SEP346 XRAY 2.31 0.211 0.236 A 322.0 275.0 19 30 25 5 [[183, 456]] 1.0 6rfi Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6RFIB Q9NWZ3 164 458 460.0 K1H:502 Type1 Inactive DFGin 7.0642 14.0503 BLAminus -129.63, 173.33 61.36, 88.99 -110.28, 17.12 308.46, 99.08 -63.95, -28.47 in-out in 8.8564 Saltbr-out 4.3159 HRD-in -66.26, -50.83 78.99, -1.16 out-in-in SNCoii in-in ActLoopNT-in 2.7779 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.66, 154.17 APE9-dihe-na 132.35, -169.11 APE8-dihe-in -111.83, 120.53 APE8-rot-in 311.0 APE67-dihe-in -70.4, -14.87 -59.89, -31.07 APE12-dist-in 10.04 APE11-dist-in 11.875 APE10-dist-in 6.3304 APE9-dist-in 3.7215 None TPO345,SEP346 TPO345,SEP346 XRAY 2.31 0.211 0.236 B 322.0 280.0 15 30 22 8 [[183, 456]] 1.0 6rfi Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6RFJA Q9NWZ3 165 458 460.0 K1E:501 Type1 Inactive DFGin 6.7312 14.2145 BLAminus -138.26, 177.45 62.01, 88.8 -111.36, 12.54 307.73, 96.46 -63.8, -18.03 in-out in 8.9085 Saltbr-out 4.5689 HRD-in -70.21, -47.87 75.12, -3.47 out-in-in SNCoii in-in ActLoopNT-in 2.7494 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.34, 157.08 APE9-dihe-na 130.62, -174.05 APE8-dihe-in -112.58, 112.94 APE8-rot-in 303.06 APE67-dihe-in -64.16, -16.63 -45.12, -46.37 APE12-dist-in 9.991 APE11-dist-in 11.846 APE10-dist-in 6.2324 APE9-dist-in 3.6713 None TPO345,SEP346 TPO345,SEP346 XRAY 2.61 0.245 0.254 A 322.0 268.0 26 30 23 7 [[183, 456]] 1.0 6rfj Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6RFJB Q9NWZ3 164 458 460.0 K1E:502 Type1 Inactive DFGin 6.98 14.2477 BLAminus -131.73, 178.64 60.17, 79.36 -102.97, 22.96 313.3, 93.8 -64.31, -22.35 in-out in 9.0016 Saltbr-out 4.973 HRD-in -70.9, -51.42 81.49, -4.07 out-in-in SNCoii in-in ActLoopNT-in 2.7843 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.43, 154.68 APE9-dihe-na 135.37, -174.43 APE8-dihe-in -109.42, 116.51 APE8-rot-in 308.77 APE67-dihe-in -61.15, -17.08 -52.21, -44.98 APE12-dist-in 10.1202 APE11-dist-in 11.8217 APE10-dist-in 6.2407 APE9-dist-in 3.8303 None TPO345,SEP346 TPO345,SEP346 XRAY 2.61 0.245 0.254 B 322.0 279.0 16 30 22 8 [[183, 456]] 1.0 6rfj Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 7QG1A Q9NWZ3 165 458 460.0 B8I:501 Type1 Inactive DFGin 7.02 14.3894 BLAminus -118.81, -178.64 55.1, 76.86 -97.97, 21.19 305.6, 72.54 -63.87, -32.47 in-out in 8.4699 Saltbr-out 5.3619 HRD-in -68.86, -48.74 75.05, -2.97 out-in-in SNCoii in-in ActLoopNT-in 2.8001 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.97, 148.67 APE9-dihe-na 139.86, -177.08 APE8-dihe-in -100.51, 118.37 APE8-rot-in 305.34 APE67-dihe-in -60.75, -17.99 -59.84, -38.95 APE12-dist-in 10.0839 APE11-dist-in 11.8182 APE10-dist-in 6.3351 APE9-dist-in 4.0571 None TPO345,SEP346 TPO345,SEP346 XRAY 2.07 0.249 0.285 A 322.0 266.0 28 30 23 7 [[183, 456]] 1.0 7qg1 Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 7QG1B Q9NWZ3 164 458 460.0 B8I:501 Type1 Inactive DFGin 7.2031 14.7406 BLAminus -127.97, 179.77 66.68, 77.1 -104.37, 20.94 303.7, 91.21 -70.61, -31.96 in-out in 8.7539 Saltbr-out 4.3527 HRD-in -69.99, -48.76 75.97, -2.57 out-in-in SNCoii in-in ActLoopNT-in 2.773 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.49, 147.07 APE9-dihe-na 141.42, -176.13 APE8-dihe-in -101.1, 117.88 APE8-rot-in 306.31 APE67-dihe-in -60.31, -17.27 -61.18, -38.28 APE12-dist-in 10.0926 APE11-dist-in 11.7254 APE10-dist-in 6.2972 APE9-dist-in 4.1112 None TPO345,SEP346 TPO345,SEP346 XRAY 2.07 0.249 0.285 B 322.0 282.0 13 30 23 7 [[183, 456]] 1.0 7qg1 Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5UIQA Q9NWZ3 164 459 460.0 8BV:501 Type1 Inactive DFGin 6.9307 14.3095 BLAminus -127.76, 177.14 59.33, 95.8 -119.34, 15.89 308.77, 95.83 -65.11, -29.47 in-out in 8.6504 Saltbr-out 4.3022 HRD-in -67.28, -50.5 79.56, -0.59 out-in-in SNCoii in-in ActLoopNT-in 2.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.14, 152.7 APE9-dihe-na 138.15, -166.94 APE8-dihe-in -116.13, 111.27 APE8-rot-in 312.43 APE67-dihe-in -63.93, -18.01 -42.44, -46.16 APE12-dist-in 9.8691 APE11-dist-in 11.872 APE10-dist-in 6.4418 APE9-dist-in 3.9304 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.64 0.199 0.226 A 323.0 271.0 25 30 26 4 [[183, 456]] 1.0 5uiq Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5UIQB Q9NWZ3 164 458 460.0 8BV:501 Type1 Inactive DFGin 6.8044 14.3759 BLAminus -130.56, -176.5 54.94, 94.68 -118.91, 16.72 307.57, 95.93 -64.01, -29.62 in-out in 8.8285 Saltbr-out 4.3856 HRD-in -70.9, -49.5 78.92, -1.32 out-in-in SNCoii in-in ActLoopNT-in 2.8073 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.36, 153.22 APE9-dihe-na 140.63, -165.78 APE8-dihe-in -116.87, 110.95 APE8-rot-in 311.97 APE67-dihe-in -63.22, -18.39 -42.29, -46.59 APE12-dist-in 9.9707 APE11-dist-in 11.8372 APE10-dist-in 6.4033 APE9-dist-in 3.9043 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.64 0.199 0.226 B 323.0 275.0 20 30 25 5 [[183, 456]] 1.0 5uiq Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5UIQC Q9NWZ3 164 458 460.0 8BV:501 Type1 Inactive DFGin 6.9897 14.0885 BLAminus -129.3, 173.99 64.73, 91.59 -115.5, 16.73 307.85, 97.93 -64.38, -30.3 in-out in 8.7851 Saltbr-out 4.4015 HRD-in -65.88, -50.65 76.92, 0.42 out-in-in SNCoii in-in ActLoopNT-in 2.7926 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.19, 152.87 APE9-dihe-na 139.13, -167.26 APE8-dihe-in -115.65, 111.65 APE8-rot-in 310.37 APE67-dihe-in -63.01, -19.88 -42.68, -46.48 APE12-dist-in 9.6424 APE11-dist-in 11.8309 APE10-dist-in 6.3933 APE9-dist-in 3.8996 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.64 0.199 0.226 C 323.0 283.0 12 30 26 4 [[183, 456]] 1.0 5uiq Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5UIQD Q9NWZ3 164 458 460.0 8BV:501 Type1 Inactive DFGin 6.9589 14.2657 BLAminus -119.1, 174.77 64.33, 95.9 -120.23, 16.26 309.43, 94.98 -65.41, -29.0 in-out in 8.6314 Saltbr-out 4.2615 HRD-in -57.37, -47.98 74.72, -2.81 out-in-in SNCoii in-in ActLoopNT-in 2.9316 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.96, 150.91 APE9-dihe-na 138.88, -168.68 APE8-dihe-in -114.25, 111.41 APE8-rot-in 310.92 APE67-dihe-in -61.78, -19.41 -45.33, -46.22 APE12-dist-in 9.6136 APE11-dist-in 11.7923 APE10-dist-in 6.3731 APE9-dist-in 3.99 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.64 0.199 0.226 D 323.0 274.0 21 30 24 6 [[183, 456]] 1.0 5uiq Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5UIRA Q9NWZ3 165 458 460.0 8BY:800 Type1 Inactive DFGin 6.9354 14.1138 BLAminus -136.3, 170.5 69.87, 91.85 -112.04, 22.11 309.32, 96.71 -72.39, -36.2 in-out in 8.9664 Saltbr-out 3.7468 HRD-in -63.83, -51.01 78.63, 2.17 out-in-in SNCoii in-in ActLoopNT-in 2.7969 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.87, 150.35 APE9-dihe-na 136.71, -173.51 APE8-dihe-in -100.71, 112.33 APE8-rot-in 315.74 APE67-dihe-in -65.12, -20.89 -48.07, -45.69 APE12-dist-in 9.847 APE11-dist-in 11.5689 APE10-dist-in 6.4183 APE9-dist-in 4.3194 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.64 0.222 0.277 A 323.0 272.0 22 30 22 8 [[183, 456]] 1.0 5uir Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5UIRB Q9NWZ3 164 458 460.0 8BY:801 Type1 Inactive DFGin 6.9002 14.2024 BLAminus -136.36, 170.65 70.05, 91.83 -112.72, 22.02 309.43, 96.93 -72.89, -36.25 in-out in 8.8243 Saltbr-out 3.616 HRD-in -62.53, -51.23 78.89, 1.88 out-in-in SNCoii in-in ActLoopNT-in 2.7897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.66, 150.06 APE9-dihe-na 137.27, -173.33 APE8-dihe-in -99.83, 112.61 APE8-rot-in 313.76 APE67-dihe-in -66.01, -19.75 -48.02, -45.39 APE12-dist-in 9.8686 APE11-dist-in 11.6908 APE10-dist-in 6.4823 APE9-dist-in 4.2738 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.64 0.222 0.277 B 323.0 276.0 19 30 25 5 [[183, 456]] 1.0 5uir Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5UISA Q9NWZ3 165 458 460.0 8C1:800 Type1 Inactive DFGin 7.1118 14.0398 BLAminus -129.58, 176.58 61.82, 86.42 -113.89, 16.49 308.82, 94.47 -62.9, -34.09 in-out in 8.541 Saltbr-out 5.5548 HRD-in -63.14, -50.87 76.52, -0.1 out-in-in SNCoii in-in ActLoopNT-in 2.7767 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.1, 153.54 APE9-dihe-na 136.54, -173.47 APE8-dihe-in -104.82, 108.83 APE8-rot-in 309.6 APE67-dihe-in -61.86, -20.01 -38.21, -50.94 APE12-dist-in 10.0387 APE11-dist-in 11.8275 APE10-dist-in 6.4632 APE9-dist-in 3.9028 None TPO342,TPO345 TPO342,TPO345 XRAY 2.5 0.235 0.25 A 323.0 270.0 24 30 22 8 [[183, 456]] 1.0 5uis Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5UISB Q9NWZ3 165 458 460.0 8C1:801 Type1 Inactive DFGin 7.1692 13.9676 BLAminus -129.92, 177.17 60.99, 86.93 -113.16, 17.11 308.88, 93.79 -61.36, -35.46 in-out in 8.7441 Saltbr-out 6.5207 HRD-in -63.03, -51.01 76.25, -0.93 out-in-in SNCoii in-in ActLoopNT-in 2.7744 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.05, 154.43 APE9-dihe-na 135.24, -173.1 APE8-dihe-in -105.0, 108.25 APE8-rot-in 310.98 APE67-dihe-in -62.29, -20.41 -37.93, -50.24 APE12-dist-in 10.0863 APE11-dist-in 11.8055 APE10-dist-in 6.4182 APE9-dist-in 3.8972 None TPO342,TPO345 TPO342,TPO345 XRAY 2.5 0.235 0.25 B 323.0 275.0 19 30 23 7 [[183, 456]] 1.0 5uis Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5UISC Q9NWZ3 162 458 460.0 8C1:501 Type1 Inactive DFGin 7.0074 14.3874 BLAminus -130.49, 177.24 60.84, 87.43 -113.94, 16.73 308.87, 94.61 -62.1, -34.09 in-out in 8.8684 Saltbr-out 5.5617 HRD-in -63.44, -49.93 76.07, -0.4 out-in-in SNCoii in-in ActLoopNT-in 2.7889 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.1, 154.4 APE9-dihe-na 135.33, -172.81 APE8-dihe-in -104.91, 108.2 APE8-rot-in 311.65 APE67-dihe-in -62.59, -19.93 -37.82, -50.44 APE12-dist-in 10.0518 APE11-dist-in 11.9322 APE10-dist-in 6.5257 APE9-dist-in 3.8867 None TPO342,TPO345 TPO342,TPO345 XRAY 2.5 0.235 0.25 C 323.0 271.0 26 30 22 8 [[183, 456]] 1.0 5uis Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5UISD Q9NWZ3 165 458 460.0 8C1:501 Type1 Inactive DFGin 6.9195 14.3084 BLAminus -130.03, 177.09 61.04, 87.02 -113.16, 16.71 309.14, 94.51 -62.12, -34.57 in-out in 8.8176 Saltbr-out 6.5419 HRD-in -64.13, -50.74 76.91, 0.02 out-in-in SNCoii in-in ActLoopNT-in 2.7878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.65, 153.91 APE9-dihe-na 135.71, -173.08 APE8-dihe-in -105.05, 108.68 APE8-rot-in 311.81 APE67-dihe-in -63.27, -19.62 -38.27, -49.96 APE12-dist-in 10.0324 APE11-dist-in 11.8269 APE10-dist-in 6.4561 APE9-dist-in 3.9118 None TPO342,TPO345 TPO342,TPO345 XRAY 2.5 0.235 0.25 D 323.0 251.0 43 30 22 8 [[183, 456]] 1.0 5uis Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5UITA Q9NWZ3 162 458 460.0 8CD:501 Type1 Inactive DFGin 6.7656 14.1309 BLAminus -128.38, 174.25 65.21, 85.43 -108.44, 15.88 303.94, 92.71 -57.19, -35.46 in-out in 8.8471 Saltbr-out 4.6146 HRD-in -70.51, -45.47 75.95, -8.98 out-in-in SNCoii in-in ActLoopNT-in 2.7454 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.37, 160.28 APE9-dihe-na 137.06, -174.06 APE8-dihe-in -107.79, 113.28 APE8-rot-in 302.72 APE67-dihe-in -66.32, -7.6 -45.31, -45.85 APE12-dist-in 9.8884 APE11-dist-in 11.6608 APE10-dist-in 6.1877 APE9-dist-in 3.6535 None TPO345,SEP346 TPO345,SEP346 XRAY 1.84 0.183 0.218 A 323.0 286.0 11 30 25 5 [[183, 456]] 1.0 5uit Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5UITB Q9NWZ3 164 458 460.0 8CD:501 Type1 Inactive DFGin 6.9737 13.9393 BLAminus -129.91, 176.45 70.0, 83.22 -107.54, 18.86 303.43, 95.85 -65.97, -22.62 in-out in 8.6891 Saltbr-out 5.2639 HRD-in -66.11, -49.66 75.87, -4.01 out-in-in SNCoii in-in ActLoopNT-in 2.615 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.66, 166.35 APE9-dihe-na 133.13, -174.76 APE8-dihe-in -106.63, 115.01 APE8-rot-in 307.0 APE67-dihe-in -65.75, -11.97 -51.76, -39.05 APE12-dist-in 9.7232 APE11-dist-in 11.7832 APE10-dist-in 6.5251 APE9-dist-in 3.674 None TPO345,SEP346 TPO345,SEP346 XRAY 1.84 0.183 0.218 B 323.0 285.0 10 30 25 5 [[183, 456]] 1.0 5uit Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5UIUA Q9NWZ3 165 458 460.0 8CG:4000 Type1 Inactive DFGin 7.0714 14.1912 BLAminus -128.0, 178.75 57.4, 86.68 -103.61, 15.12 305.49, 98.8 -59.8, -27.73 in-out in 9.029 Saltbr-out 3.9038 HRD-in -69.77, -50.91 79.77, -5.91 out-in-in SNCoii in-in ActLoopNT-in 2.7343 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.31, 159.24 APE9-dihe-na 132.22, -173.23 APE8-dihe-in -109.61, 111.77 APE8-rot-in 308.77 APE67-dihe-in -62.44, -17.23 -49.55, -40.12 APE12-dist-in 10.0557 APE11-dist-in 11.9469 APE10-dist-in 6.4345 APE9-dist-in 3.8865 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.02 0.186 0.204 A 323.0 289.0 5 30 25 5 [[183, 456]] 1.0 5uiu Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5UIUB Q9NWZ3 164 458 460.0 8CG:4000 Type1 Inactive DFGin 7.0024 14.0448 BLAminus -130.9, 173.2 66.57, 85.65 -106.49, 15.18 305.82, 98.74 -60.25, -27.45 in-out in 9.0772 Saltbr-out 4.1991 HRD-in -69.82, -51.52 78.72, -3.57 out-in-in SNCoii in-in ActLoopNT-in 2.7287 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.42, 157.5 APE9-dihe-na 132.2, -173.12 APE8-dihe-in -109.05, 111.57 APE8-rot-in 309.25 APE67-dihe-in -61.49, -18.85 -44.37, -45.98 APE12-dist-in 10.1021 APE11-dist-in 11.9995 APE10-dist-in 6.4787 APE9-dist-in 3.9707 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.02 0.186 0.204 B 323.0 290.0 5 30 25 5 [[183, 456]] 1.0 5uiu Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8W3XA Q9NWZ3 162 460 460.0 A1AFH:501 Type1 Inactive DFGin 6.7631 14.0864 BLAminus -129.8, 175.53 62.33, 85.97 -101.36, 14.33 304.54, 100.12 -62.52, -27.4 in-out in 8.8657 Saltbr-out 4.4893 HRD-in -68.21, -49.93 76.52, -2.3 out-in-in SNCoii in-in ActLoopNT-in 2.8548 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.65, 160.15 APE9-dihe-na 133.09, -174.82 APE8-dihe-in -108.97, 112.7 APE8-rot-in 305.97 APE67-dihe-in -63.54, -15.82 -41.12, -50.5 APE12-dist-in 9.9893 APE11-dist-in 11.7283 APE10-dist-in 6.3538 APE9-dist-in 3.8624 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.765 0.191 0.212 A 323.0 289.0 10 30 25 5 [[183, 456]] 1.0 8w3x Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8W3XB Q9NWZ3 162 459 460.0 A1AFH:501 Type1 Inactive DFGin 6.7194 14.083 BLAminus -131.86, 175.94 61.72, 86.86 -102.91, 14.0 304.56, 100.34 -62.32, -27.57 in-out in 8.8165 Saltbr-out 4.434 HRD-in -69.04, -50.02 77.17, -2.0 out-in-in SNCoii in-in ActLoopNT-in 2.8469 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.36, 162.06 APE9-dihe-na 132.25, -173.81 APE8-dihe-in -109.37, 111.4 APE8-rot-in 305.14 APE67-dihe-in -62.67, -15.91 -40.92, -50.44 APE12-dist-in 10.0144 APE11-dist-in 11.7727 APE10-dist-in 6.3777 APE9-dist-in 3.7844 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.765 0.191 0.212 B 323.0 289.0 9 30 25 5 [[183, 456]] 1.0 8w3x Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8W3XC Q9NWZ3 164 459 460.0 A1AFH:501 Type1 Inactive DFGin 6.9712 14.0541 BLAminus -133.25, 171.05 66.34, 84.83 -102.34, 14.62 305.45, 100.45 -62.92, -27.96 in-out in 8.9904 Saltbr-out 4.5117 HRD-in -68.29, -50.47 77.57, -3.07 out-in-in SNCoii in-in ActLoopNT-in 2.837 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.14, 159.95 APE9-dihe-na 132.75, -174.83 APE8-dihe-in -108.93, 112.47 APE8-rot-in 307.06 APE67-dihe-in -62.79, -16.23 -41.81, -49.04 APE12-dist-in 10.0996 APE11-dist-in 11.9677 APE10-dist-in 6.5219 APE9-dist-in 3.8336 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.765 0.191 0.212 C 323.0 288.0 8 30 26 4 [[183, 456]] 1.0 8w3x Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8W3XD Q9NWZ3 164 459 460.0 A1AFH:501 Type1 Inactive DFGin 6.9677 13.9927 BLAminus -130.92, 172.36 64.58, 86.68 -103.48, 14.54 305.1, 100.07 -62.66, -26.7 in-out in 8.8521 Saltbr-out 4.3981 HRD-in -69.41, -50.81 77.69, -1.46 out-in-in SNCoii in-in ActLoopNT-in 2.843 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.51, 160.43 APE9-dihe-na 133.04, -172.94 APE8-dihe-in -110.16, 111.74 APE8-rot-in 305.95 APE67-dihe-in -63.06, -15.81 -41.04, -49.97 APE12-dist-in 9.9983 APE11-dist-in 11.7911 APE10-dist-in 6.4283 APE9-dist-in 3.8999 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.765 0.191 0.212 D 323.0 287.0 9 30 26 4 [[183, 456]] 1.0 8w3x Homo sapiens TKL_IRAK4_HUMAN TKL 5.2e-84 287.9 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8V1OA Q9NWZ3 163 459 460.0 Y9T:501 Type1 Inactive DFGin 6.8549 14.2482 BLAminus -140.64, 168.57 69.95, 86.27 -108.05, 19.4 305.86, 96.59 -62.38, -30.29 in-out in 8.9505 Saltbr-out 4.347 HRD-in -60.57, -58.78 78.86, 6.37 out-in-in SNCoii in-in ActLoopNT-in 2.7463 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.84, 152.18 APE9-dihe-na 140.36, 176.78 APE8-dihe-in -102.6, 111.09 APE8-rot-in 311.94 APE67-dihe-in -57.16, -25.0 -36.59, -53.2 APE12-dist-in 9.9458 APE11-dist-in 11.7778 APE10-dist-in 6.4265 APE9-dist-in 3.6969 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.92 0.219 0.266 A 327.0 290.0 7 30 27 3 [[183, 456]] 1.0 8v1o Homo sapiens TKL_IRAK4_HUMAN TKL 5.5e-84 287.8 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8V1OB Q9NWZ3 164 459 460.0 Y9T:501 Type1 Inactive DFGin 6.8614 14.2977 BLAminus -140.52, 168.93 69.44, 87.06 -107.94, 19.45 305.05, 96.72 -62.6, -30.13 in-out in 8.769 Saltbr-out 3.6904 HRD-in -60.51, -59.01 78.22, 6.98 out-in-in SNCoii in-in ActLoopNT-in 2.7706 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.06, 153.17 APE9-dihe-na 139.34, 176.48 APE8-dihe-in -102.52, 110.93 APE8-rot-in 310.58 APE67-dihe-in -54.87, -25.59 -38.21, -52.86 APE12-dist-in 10.0158 APE11-dist-in 11.6891 APE10-dist-in 6.2662 APE9-dist-in 3.6553 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.92 0.219 0.266 B 327.0 289.0 7 30 27 3 [[183, 456]] 1.0 8v1o Homo sapiens TKL_IRAK4_HUMAN TKL 5.5e-84 287.8 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8V1OC Q9NWZ3 163 459 460.0 Y9T:501 Type1 Inactive DFGin 6.9152 14.164 BLAminus -140.19, 169.04 68.79, 87.36 -108.28, 19.76 305.21, 96.76 -61.62, -32.73 in-out in 8.8991 Saltbr-out 4.0595 HRD-in -60.61, -59.09 78.04, 8.77 out-in-in SNCoii in-in ActLoopNT-in 2.776 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.34, 152.45 APE9-dihe-na 142.6, 179.16 APE8-dihe-in -102.2, 110.2 APE8-rot-in 311.46 APE67-dihe-in -56.49, -25.16 -38.09, -52.95 APE12-dist-in 9.9908 APE11-dist-in 11.5248 APE10-dist-in 6.209 APE9-dist-in 3.69 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.92 0.219 0.266 C 327.0 292.0 5 30 30 0 [[183, 456]] 1.0 8v1o Homo sapiens TKL_IRAK4_HUMAN TKL 5.5e-84 287.8 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8V1OD Q9NWZ3 163 459 460.0 Y9T:501 Type1 Inactive DFGin 6.8497 14.2684 BLAminus -140.2, 169.66 70.3, 86.25 -107.86, 18.94 306.2, 96.68 -63.07, -30.17 in-out in 8.7571 Saltbr-out 4.0511 HRD-in -61.84, -59.06 77.97, 8.8 out-in-in SNCoii in-in ActLoopNT-in 2.7789 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.76, 152.94 APE9-dihe-na 140.97, 176.36 APE8-dihe-in -102.92, 110.82 APE8-rot-in 311.53 APE67-dihe-in -56.93, -25.15 -39.7, -51.03 APE12-dist-in 10.0789 APE11-dist-in 11.7528 APE10-dist-in 6.4009 APE9-dist-in 3.6968 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.92 0.219 0.266 D 327.0 288.0 9 30 25 5 [[183, 456]] 1.0 8v1o Homo sapiens TKL_IRAK4_HUMAN TKL 5.5e-84 287.8 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8V2FA Q9NWZ3 163 459 460.0 YJU:60501 Type1 Inactive DFGin 6.8702 13.9122 BLAminus -130.46, 167.87 71.07, 88.15 -105.99, 14.17 306.33, 105.04 -63.43, -29.84 in-out in 8.7525 Saltbr-out 6.6469 HRD-in -75.59, -51.25 77.14, -1.53 out-in-in SNCoii in-in ActLoopNT-in 2.7595 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.46, 160.72 APE9-dihe-na 130.93, -172.56 APE8-dihe-in -109.8, 115.15 APE8-rot-in 307.79 APE67-dihe-in -64.1, -12.85 -49.44, -45.85 APE12-dist-in 9.9997 APE11-dist-in 11.6907 APE10-dist-in 6.2636 APE9-dist-in 3.8414 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.09 0.17 0.208 A 327.0 297.0 0 30 30 0 [[183, 456]] 1.0 8v2f Homo sapiens TKL_IRAK4_HUMAN TKL 5.5e-84 287.8 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8V2FB Q9NWZ3 162 459 460.0 YJU:60501 Type1 Inactive DFGin 6.791 13.9203 BLAminus -128.51, 168.52 71.95, 86.21 -105.97, 13.84 307.27, 104.55 -61.45, -29.65 in-out in 8.6134 Saltbr-out 4.6866 HRD-in -73.0, -49.88 77.29, -2.9 out-in-in SNCoii in-in ActLoopNT-in 2.7666 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.29, 159.97 APE9-dihe-na 133.0, -176.78 APE8-dihe-in -107.14, 116.65 APE8-rot-in 305.27 APE67-dihe-in -65.9, -12.4 -47.02, -47.36 APE12-dist-in 9.8602 APE11-dist-in 11.7515 APE10-dist-in 6.2634 APE9-dist-in 3.7427 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.09 0.17 0.208 B 327.0 298.0 0 30 30 0 [[183, 456]] 1.0 8v2f Homo sapiens TKL_IRAK4_HUMAN TKL 5.5e-84 287.8 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8V2FC Q9NWZ3 160 459 460.0 YJU:60501 Type1 Inactive DFGin 6.7489 13.9597 BLAminus -128.52, 169.77 69.32, 87.03 -106.73, 13.85 307.97, 104.15 -62.29, -28.75 in-out in 8.627 Saltbr-out 4.5488 HRD-in -75.43, -50.45 76.09, 0.63 out-in-in SNCoii in-in ActLoopNT-in 2.7812 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.14, 162.06 APE9-dihe-na 130.19, -174.89 APE8-dihe-in -108.77, 116.12 APE8-rot-in 305.67 APE67-dihe-in -65.6, -13.25 -47.01, -47.42 APE12-dist-in 9.8432 APE11-dist-in 11.6233 APE10-dist-in 6.0978 APE9-dist-in 3.7165 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.09 0.17 0.208 C 327.0 300.0 0 30 30 0 [[183, 456]] 1.0 8v2f Homo sapiens TKL_IRAK4_HUMAN TKL 5.5e-84 287.8 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8V2FD Q9NWZ3 163 459 460.0 YJU:60501 Type1 Inactive DFGin 6.86 14.0001 BLAminus -128.26, 168.26 72.7, 86.48 -106.33, 14.33 307.69, 103.31 -60.7, -31.69 in-out in 8.8572 Saltbr-out 6.2889 HRD-in -76.04, -50.4 78.3, -1.88 out-in-in SNCoii in-in ActLoopNT-in 2.7509 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.81, 159.65 APE9-dihe-na 129.85, -177.51 APE8-dihe-in -108.36, 116.16 APE8-rot-in 308.63 APE67-dihe-in -62.97, -13.61 -47.53, -48.41 APE12-dist-in 10.0513 APE11-dist-in 11.8961 APE10-dist-in 6.3897 APE9-dist-in 3.7603 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.09 0.17 0.208 D 327.0 294.0 3 30 27 3 [[183, 456]] 1.0 8v2f Homo sapiens TKL_IRAK4_HUMAN TKL 5.5e-84 287.8 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8V2LA Q9NWZ3 164 459 460.0 YK0:501 Type1 Inactive DFGin 6.6037 13.4056 BLAminus -121.21, 172.86 64.77, 85.79 -107.22, 18.27 310.33, 96.01 -58.61, -41.96 in-out in 8.0401 Saltbr-out 4.2802 HRD-in -62.46, -51.84 78.02, 3.1 out-in-in SNCoii in-in ActLoopNT-in 2.6112 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.97, 166.5 APE9-dihe-na 120.32, -177.29 APE8-dihe-in -108.05, 112.93 APE8-rot-in 310.64 APE67-dihe-in -64.75, -16.58 -36.82, -53.61 APE12-dist-in 9.3452 APE11-dist-in 11.3313 APE10-dist-in 5.8782 APE9-dist-in 3.2645 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.43 0.255 0.302 A 327.0 291.0 5 30 25 5 [[183, 456]] 1.0 8v2l Homo sapiens TKL_IRAK4_HUMAN TKL 5.5e-84 287.8 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8V2LB Q9NWZ3 163 459 460.0 YK0:501 Type1 Inactive DFGin 6.6197 13.3492 BLAminus -120.96, 172.67 64.91, 85.77 -106.56, 17.9 310.1, 96.45 -58.62, -41.82 in-out in 7.9848 Saltbr-out 3.8758 HRD-in -62.59, -51.36 77.4, 3.79 out-in-in SNCoii in-in ActLoopNT-in 2.6128 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.09, 166.75 APE9-dihe-na 122.3, -175.29 APE8-dihe-in -107.71, 112.62 APE8-rot-in 309.44 APE67-dihe-in -64.15, -17.62 -36.19, -53.73 APE12-dist-in 9.2748 APE11-dist-in 11.2494 APE10-dist-in 5.7935 APE9-dist-in 3.2243 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.43 0.255 0.302 B 327.0 292.0 5 30 25 5 [[183, 456]] 1.0 8v2l Homo sapiens TKL_IRAK4_HUMAN TKL 5.5e-84 287.8 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8V2LC Q9NWZ3 164 459 460.0 YK0:501 Type1 Inactive DFGin 6.5519 13.5417 BLAminus -121.25, 173.26 64.05, 86.32 -106.85, 17.63 309.75, 95.82 -58.65, -40.64 in-out in 7.9726 Saltbr-out 3.8686 HRD-in -62.33, -51.39 77.94, 3.4 out-in-in SNCoii in-in ActLoopNT-in 2.607 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.03, 167.23 APE9-dihe-na 120.49, -177.04 APE8-dihe-in -107.34, 112.53 APE8-rot-in 310.89 APE67-dihe-in -65.65, -16.07 -36.38, -53.95 APE12-dist-in 9.2763 APE11-dist-in 11.2987 APE10-dist-in 5.8444 APE9-dist-in 3.232 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.43 0.255 0.302 C 327.0 291.0 5 30 25 5 [[183, 456]] 1.0 8v2l Homo sapiens TKL_IRAK4_HUMAN TKL 5.5e-84 287.8 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8V2LD Q9NWZ3 164 459 460.0 YK0:501 Type1 Inactive DFGin 6.5695 13.4784 BLAminus -121.17, 172.07 65.62, 86.14 -107.29, 16.86 310.43, 82.27 -58.81, -41.47 in-out in 7.8793 Saltbr-out 3.8558 HRD-in -62.38, -51.53 78.2, 3.12 out-in-in SNCoii in-in ActLoopNT-in 2.6133 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.11, 167.04 APE9-dihe-na 120.53, -178.59 APE8-dihe-in -107.42, 112.59 APE8-rot-in 311.17 APE67-dihe-in -65.49, -16.09 -36.28, -53.87 APE12-dist-in 9.5025 APE11-dist-in 11.3431 APE10-dist-in 5.9014 APE9-dist-in 3.2603 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.43 0.255 0.302 D 327.0 291.0 5 30 25 5 [[183, 456]] 1.0 8v2l Homo sapiens TKL_IRAK4_HUMAN TKL 5.5e-84 287.8 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8ATBAAA Q9NWZ3 165 459 460.0 O0H:501 Type1 Inactive DFGin 6.9325 14.0449 BLAminus -121.47, 173.79 68.09, 102.5 -125.51, 19.89 306.28, 88.96 -63.31, -35.55 in-out in 9.0143 Saltbr-out 4.7306 HRD-in -76.64, -56.17 81.36, 1.11 out-in-in SNCoii in-in ActLoopNT-in 2.7117 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.25, 147.68 APE9-dihe-na 138.07, -176.27 APE8-dihe-in -102.25, 110.92 APE8-rot-in 311.13 APE67-dihe-in -58.31, -27.03 -61.07, -35.05 APE12-dist-in 10.3429 APE11-dist-in 11.7734 APE10-dist-in 6.4836 APE9-dist-in 4.0423 K400A,E401A,E402A TPO345,SEP346 CSO240,CSO289,TPO345,SEP346 XRAY 2.35 0.214 0.26 AAA 298.0 280.0 15 30 22 8 [[183, 456]] 1.0 8atb Homo sapiens TKL_IRAK4_HUMAN TKL 1.3e-83 286.6 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8ATBBBB Q9NWZ3 165 459 460.0 O0H:501 Type1 Inactive DFGin 7.2148 13.7854 BLAminus -128.79, 170.66 65.65, 84.73 -111.53, 16.19 311.14, 85.88 -77.86, -13.48 in-out in 8.5669 Saltbr-out 7.2399 HRD-in -72.73, -56.78 83.28, 0.6 out-in-in SNCoii in-in ActLoopNT-in 2.6798 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.97, 161.24 APE9-dihe-na 134.69, -177.34 APE8-dihe-in -106.53, 101.49 APE8-rot-in 315.43 APE67-dihe-in -62.03, -21.88 -37.43, -49.3 APE12-dist-in 10.6974 APE11-dist-in 12.0305 APE10-dist-in 7.3801 APE9-dist-in 4.3329 K400A,E401A,E402A TPO345,SEP346 CSO240,CSO289,TPO345,SEP346 XRAY 2.35 0.214 0.26 BBB 298.0 282.0 13 30 24 6 [[183, 456]] 1.0 8atb Homo sapiens TKL_IRAK4_HUMAN TKL 1.3e-83 286.6 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8ATNAAA Q9NWZ3 165 459 460.0 O06:1001 Type1 Inactive DFGin 6.7239 14.2081 BLAminus -117.77, 176.24 64.77, 96.31 -125.83, 10.5 313.57, 103.82 -69.05, -5.63 in-out in 8.6317 Saltbr-out 4.5649 HRD-in -69.73, -51.11 77.51, -5.14 out-in-in SNCoii in-in ActLoopNT-in 2.8391 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.0, 157.33 APE9-dihe-na 133.5, -162.12 APE8-dihe-in -121.39, 112.47 APE8-rot-in 318.21 APE67-dihe-in -71.32, -7.35 -41.66, -51.09 APE12-dist-in 9.9019 APE11-dist-in 12.0467 APE10-dist-in 7.0691 APE9-dist-in 3.8594 K400A,E401A,E402A TPO345,SEP346 TPO345,SEP346 XRAY 2.171 0.242 0.306 AAA 298.0 282.0 13 30 25 5 [[183, 456]] 1.0 8atn Homo sapiens TKL_IRAK4_HUMAN TKL 1.3e-83 286.6 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8ATNBBB Q9NWZ3 165 459 460.0 O06:1001 Type1 Inactive DFGin 6.4704 14.0241 BLAminus -130.98, 162.78 71.1, 84.67 -104.49, 21.53 314.64, 81.97 -66.59, -34.68 in-out in 8.5199 Saltbr-out 5.3387 HRD-in -69.18, -52.19 77.12, 4.45 out-in-in SNCoii in-in ActLoopNT-in 2.5999 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.72, 153.2 APE9-dihe-na 145.05, 176.75 APE8-dihe-in -102.56, 117.31 APE8-rot-in 320.99 APE67-dihe-in -62.43, -13.54 -50.51, -47.21 APE12-dist-in 9.7364 APE11-dist-in 11.5133 APE10-dist-in 6.4449 APE9-dist-in 4.1015 K400A,E401A,E402A TPO345,SEP346 TPO345,SEP346 XRAY 2.171 0.242 0.306 BBB 298.0 286.0 9 30 27 3 [[183, 456]] 1.0 8atn Homo sapiens TKL_IRAK4_HUMAN TKL 1.3e-83 286.6 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8BR6AAA Q9NWZ3 165 459 460.0 R6I:1001 Type1 Inactive DFGin 6.9174 13.8173 BLAminus -129.66, 170.0 69.62, 98.1 -122.85, 19.7 306.96, 88.76 -58.16, -37.07 in-out in 8.8089 Saltbr-out 7.4707 HRD-in -72.91, -58.78 84.26, 5.42 out-in-in SNCoii in-in ActLoopNT-in 2.7532 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.53, 152.76 APE9-dihe-na 145.18, -171.68 APE8-dihe-in -111.26, 112.24 APE8-rot-in 315.6 APE67-dihe-in -61.85, -25.79 -58.99, -34.36 APE12-dist-in 9.9925 APE11-dist-in 11.9713 APE10-dist-in 6.8577 APE9-dist-in 3.9736 K400A,E401A,E402A TPO345,SEP346 TPO345,SEP346 XRAY 2.167 0.215 0.251 AAA 298.0 288.0 7 30 23 7 [[183, 456]] 1.0 8br6 Homo sapiens TKL_IRAK4_HUMAN TKL 1.3e-83 286.6 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8BR6BBB Q9NWZ3 165 459 460.0 R6I:1001 Type1 Inactive DFGin 7.2141 14.1156 BLAminus -122.04, 169.11 67.87, 99.68 -120.93, 27.62 310.0, 104.06 -68.88, -33.21 in-out in 9.2138 Saltbr-out 4.1674 HRD-in -70.69, -55.19 81.72, -1.09 out-in-in SNCoii in-in ActLoopNT-in 3.038 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.8, 91.66 APE9-dihe-na -148.3, -158.25 APE8-dihe-in -114.14, 110.31 APE8-rot-in 308.07 APE67-dihe-in -68.26, -15.15 -42.56, -51.42 APE12-dist-in 10.1107 APE11-dist-in 11.7081 APE10-dist-in 6.6862 APE9-dist-in 3.8899 K400A,E401A,E402A TPO345,SEP346 TPO345,SEP346 XRAY 2.167 0.215 0.251 BBB 298.0 278.0 17 30 24 6 [[183, 456]] 1.0 8br6 Homo sapiens TKL_IRAK4_HUMAN TKL 1.3e-83 286.6 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8BR7AAA Q9NWZ3 165 458 460.0 R6R:501 Type1 Inactive DFGin 6.7483 13.7843 BLAminus -121.68, 175.13 64.52, 68.33 -88.96, 4.22 313.41, 97.24 -60.18, 142.14 in-out in 8.2357 Saltbr-out 7.7831 HRD-in -69.56, -54.74 85.52, -4.41 out-in-in SNCoii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.26, 163.97 APE9-dihe-na 117.6, -170.85 APE8-dihe-in -114.4, 114.65 APE8-rot-in 314.25 APE67-dihe-in -62.57, -14.8 -45.12, -53.09 APE12-dist-in 9.6098 APE11-dist-in 11.5218 APE10-dist-in 6.0807 APE9-dist-in 3.6881 K400A,E401A,E402A TPO345,SEP346 TPO345,SEP346 XRAY 2.119 0.241 0.288 AAA 298.0 273.0 21 30 24 6 [[183, 456]] 1.0 8br7 Homo sapiens TKL_IRAK4_HUMAN TKL 1.3e-83 286.6 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8BR7BBB Q9NWZ3 165 458 460.0 R6R:501 Type1 Inactive DFGin 6.7251 14.0843 BLAminus -127.23, 169.57 70.93, 84.26 -111.93, 23.51 310.86, 94.87 -67.5, -27.24 in-out in 9.0787 Saltbr-out 4.6695 HRD-in -74.15, -52.75 85.58, -3.83 out-in-in SNCoii in-in ActLoopNT-in 2.7055 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.6, 148.06 APE9-dihe-na 139.81, -171.92 APE8-dihe-in -112.09, 123.4 APE8-rot-in 327.06 APE67-dihe-in -62.8, -13.81 -52.63, -52.65 APE12-dist-in 10.0265 APE11-dist-in 11.8292 APE10-dist-in 6.6234 APE9-dist-in 3.9928 K400A,E401A,E402A TPO345,SEP346 TPO345,SEP346 XRAY 2.119 0.241 0.288 BBB 298.0 278.0 16 30 25 5 [[183, 456]] 1.0 8br7 Homo sapiens TKL_IRAK4_HUMAN TKL 1.3e-83 286.6 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8DKSA Q9NWZ3 165 459 460.0 SO9:501 Type1 Inactive DFGin 6.9825 14.0197 BLAminus -134.64, 178.03 63.45, 86.35 -110.27, 29.73 310.97, 98.17 -70.79, -35.85 in-out in 8.2912 Saltbr-out 4.4467 HRD-in -75.38, -48.79 72.8, 5.5 out-in-in SNCoii in-in ActLoopNT-in 2.9065 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.77, 162.36 APE9-dihe-na 128.07, -167.6 APE8-dihe-in -119.72, 111.55 APE8-rot-in 307.86 APE67-dihe-in -64.51, -15.13 -57.7, -32.23 APE12-dist-in 9.8577 APE11-dist-in 11.5245 APE10-dist-in 6.2214 APE9-dist-in 3.6652 None SEP346 SEP346 XRAY 2.45 0.215 0.267 A 460.0 283.0 12 30 23 7 [[183, 456]] 1.0 8dks Homo sapiens TKL_IRAK4_HUMAN TKL 1.6e-83 286.6 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8DKSB Q9NWZ3 164 459 460.0 SO9:501 Type1 Inactive DFGin 7.0195 14.2623 BLAminus -133.36, 172.32 69.94, 86.94 -110.0, 21.28 306.52, 104.01 -69.01, -36.15 in-out in 8.4475 Saltbr-out 4.2848 HRD-in -74.58, -51.41 77.38, 3.56 out-in-in SNCoii in-in ActLoopNT-in 2.6651 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.18, 157.32 APE9-dihe-na 125.46, -172.72 APE8-dihe-in -116.19, 115.21 APE8-rot-in 297.6 APE67-dihe-in -69.09, -18.07 -48.21, -41.4 APE12-dist-in 10.1058 APE11-dist-in 11.7004 APE10-dist-in 6.2871 APE9-dist-in 3.8575 None SEP346 SEP346 XRAY 2.45 0.215 0.267 B 460.0 278.0 18 30 24 6 [[183, 456]] 1.0 8dks Homo sapiens TKL_IRAK4_HUMAN TKL 1.6e-83 286.6 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8WTFA Q9NWZ3 165 458 460.0 8CG:501 Type1 Inactive DFGin 7.0053 14.5963 BLAminus -130.8, 171.92 71.01, 81.99 -105.62, 21.38 296.99, 92.96 -66.19, -26.61 in-out in 9.1924 Saltbr-out 4.6295 HRD-in -70.42, -54.47 79.43, 6.51 out-in-in SNCoii in-in ActLoopNT-in 2.8134 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.2, 140.94 APE9-dihe-na 161.87, -178.6 APE8-dihe-in -106.43, 100.35 APE8-rot-in 315.83 APE67-dihe-in -65.34, -20.2 -65.65, -27.46 APE12-dist-in 12.77 APE11-dist-in 10.937 APE10-dist-in 6.8234 APE9-dist-in 4.6698 None None None XRAY 2.0 0.183 0.236 A 297.0 291.0 3 30 30 0 [[183, 456]] 1.0 8wtf Homo sapiens TKL_IRAK4_HUMAN TKL 2.5e-83 285.6 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6EGDD Q9NWZ3 164 458 460.0 J87:60501 Type1 Inactive DFGin 6.9187 14.3644 BLAminus -149.78, -167.55 62.28, 69.57 -94.25, 14.81 300.14, 101.17 -61.64, -25.96 in-out in 9.0927 Saltbr-out 3.605 HRD-in -74.47, -53.77 75.51, 2.5 out-in-none SNCoin in-none ActLoopNT-in 2.7234 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -71.85, -7.72 999.0, -32.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.184 0.23 D 302.0 274.0 21 30 14 16 [[183, 456]] 1.0 6egd Homo sapiens TKL_IRAK4_HUMAN TKL 2.6e-83 285.5 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4YO6D Q9NWZ3 164 459 460.0 4GD:501,4GD:502 Type1,Allosteric Inactive DFGin 7.0074 13.7987 BLAminus -128.52, 178.14 61.39, 82.47 -106.01, 15.47 309.65, 100.13 -63.32, -35.07 in-out in 8.3085 Saltbr-out 4.1986 HRD-in -64.44, -53.47 79.17, -4.29 out-in-in SNCoii in-in ActLoopNT-in 2.6719 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.23, 153.2 APE9-dihe-na 136.75, -169.98 APE8-dihe-in -112.74, 114.12 APE8-rot-in 314.47 APE67-dihe-in -60.31, -19.69 -40.21, -53.83 APE12-dist-in 9.9637 APE11-dist-in 11.7421 APE10-dist-in 6.3209 APE9-dist-in 3.8609 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.32 0.199 0.225 D 301.0 288.0 8 30 26 4 [[183, 456]] 1.0 4yo6 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6TIAA Q9NWZ3 163 459 460.0 ND2:501,ND2:502,ND2:503,ND2:504 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 7.0563 14.7895 BLAminus -140.42, -178.87 56.13, 87.79 -104.25, 13.99 300.74, 95.94 -61.47, -11.04 in-out in 9.4587 Saltbr-out 6.4913 HRD-in -66.38, -48.88 73.85, 2.56 out-in-in SNCoii in-in ActLoopNT-in 2.803 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.91, 156.52 APE9-dihe-na 134.49, -171.44 APE8-dihe-in -101.75, 121.09 APE8-rot-in 313.72 APE67-dihe-in -68.2, -12.58 -55.04, -41.75 APE12-dist-in 10.3144 APE11-dist-in 11.8851 APE10-dist-in 6.4879 APE9-dist-in 3.5476 None TPO345,SEP346 TPO345,SEP346 XRAY 2.52 0.218 0.261 A 308.0 288.0 9 30 24 6 [[183, 456]] 1.0 6tia Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6TIAB Q9NWZ3 164 459 460.0 ND2:501,ND2:502,ND2:503,ND2:504 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 7.0823 14.767 BLAminus -129.53, 179.91 56.34, 87.3 -105.34, 14.83 301.91, 95.46 -60.96, -19.27 in-out in 9.2422 Saltbr-out 7.2036 HRD-in -65.06, -49.58 73.65, 2.87 out-in-in SNCoii in-in ActLoopNT-in 2.8143 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.9, 155.88 APE9-dihe-na 135.29, -171.62 APE8-dihe-in -102.71, 120.99 APE8-rot-in 315.19 APE67-dihe-in -67.65, -13.42 -54.79, -41.81 APE12-dist-in 10.2844 APE11-dist-in 11.9206 APE10-dist-in 6.518 APE9-dist-in 3.6049 None TPO345,SEP346 TPO345,SEP346 XRAY 2.52 0.218 0.261 B 308.0 287.0 9 30 24 6 [[183, 456]] 1.0 6tia Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 9R9KC Q9NWZ3 164 460 460.0 A1JDQ:501 Type1 Inactive DFGin 5.4273 13.7003 BLAplus -121.4, 174.92 52.96, 52.1 -113.08, 22.09 63.11, 100.55 -82.15, -34.43 in-in in 9.0044 Saltbr-in 3.5643 HRD-in -66.7, -51.75 79.98, -9.1 in-in-out SNCiio in-out ActLoopNT-in 2.8767 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -121.02, 159.56 APE9-dihe-na 135.26, -175.03 APE8-dihe-in -112.94, 115.11 APE8-rot-in 304.94 APE67-dihe-in -64.76, -11.9 -41.19, -51.22 APE12-dist-in 11.5011 APE11-dist-in 13.5883 APE10-dist-out 8.3502 APE9-dist-in 3.7071 None TPO345,SEP346 TPO345,SEP346 XRAY 1.87 0.216 0.242 C 308.0 287.0 10 30 25 5 [[183, 456]] 1.0 9r9k Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 2NRYA Q9NWZ3 164 458 460.0 STU:504 Type1 Inactive DFGin 7.0388 13.8495 BLBminus -119.68, 177.11 59.06, 71.69 -112.23, -126.05 350.98, 70.79 78.1, -70.69 in-in in 9.0302 Saltbr-in 2.7579 HRD-in -65.27, -50.09 77.33, -7.45 in-in-in SNCiii in-in ActLoopNT-in 2.7537 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.61, 161.22 APE9-dihe-na 128.42, -175.43 APE8-dihe-in -120.1, 117.97 APE8-rot-in 299.02 APE67-dihe-in -57.48, -21.15 -43.86, -55.05 APE12-dist-in 10.9882 APE11-dist-in 13.0534 APE10-dist-in 7.6703 APE9-dist-in 3.6824 None TPO345 TPO345 XRAY 2.15 0.212 0.261 A 307.0 287.0 8 30 25 5 [[183, 456]] 1.0 2nry Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 2NRYB Q9NWZ3 164 458 460.0 STU:502 Type1 Inactive DFGin 7.3303 14.2109 BLBminus -121.91, 179.32 63.59, 83.43 -104.91, -160.11 313.36, 100.13 93.41, -69.05 in-out in 8.9923 Saltbr-out 3.7751 HRD-in -74.38, -53.26 85.42, -10.52 out-in-in SNCoii in-in ActLoopNT-in 2.61 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.77, 162.03 APE9-dihe-na 124.37, -168.49 APE8-dihe-in -121.78, 111.1 APE8-rot-in 307.1 APE67-dihe-in -48.86, -28.56 -36.36, -56.5 APE12-dist-in 9.9324 APE11-dist-in 12.1379 APE10-dist-in 6.4849 APE9-dist-in 3.62 None TPO345 TPO345 XRAY 2.15 0.212 0.261 B 307.0 287.0 8 30 25 5 [[183, 456]] 1.0 2nry Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6EGFB Q9NWZ3 164 460 460.0 ANP:501 ATPlike Inactive DFGin 5.6133 16.8833 BLBtrans -116.63, 167.73 64.0, 27.84 -68.07, 138.11 161.96, 71.15 80.16, -16.86 out-out out 13.6461 Saltbr-out 13.3901 HRD-in -72.08, -42.87 70.74, 1.24 out-out-out SNCooo out-out ActLoopNT-out 6.1127 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 31.47 APE8-rot-out 178.98 APE67-dihe-in -65.08, -16.47 -76.23, -17.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.61 0.206 0.229 B 302.0 285.0 12 30 18 12 [[183, 456]] 1.0 6egf Homo sapiens TKL_IRAK4_HUMAN TKL 2.6e-83 285.5 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8TVMD Q9NWZ3 164 459 460.0 VDC:501 Type1 Inactive DFGin 7.8031 14.7146 None -126.76, 170.55 55.84, 64.27 -89.21, 999.0 333.58, 116.07 999.0, 999.0 in-out in 9.0975 Saltbr-out 4.7491 HRD-in -67.23, -50.36 76.24, -8.64 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na -109.51, 116.74 APE9-dihe-na 179.74, -172.21 APE8-dihe-in -111.79, 118.52 APE8-rot-out 41.22 APE67-dihe-in -67.21, -19.62 -56.37, -42.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.276 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.223 0.246 D 307.0 277.0 19 30 19 11 [[183, 456]] 1.0 8tvm Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4U97B Q9NWZ3 166 458 460.0 STU:501 Type1 Inactive DFGin 5.2944 14.2173 None -136.34, -175.59 46.99, 62.58 -120.73, 999.0 61.34, 86.78 999.0, 999.0 in-in in 9.393 Saltbr-in 2.9962 HRD-in -71.9, -50.3 83.45, -13.24 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -128.91, -19.36 APE9-dihe-na -55.91, 145.79 APE8-dihe-in -64.15, 91.3 APE8-rot-in 291.9 APE67-dihe-in -57.49, -34.64 -51.29, -30.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.1454 D311N None None XRAY 2.65 0.206 0.251 B 312.0 270.0 23 30 18 12 [[183, 456]] 1.0 4u97 Homo sapiens TKL_IRAK4_HUMAN TKL 3e-83 285.4 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4U9AB Q9NWZ3 166 458 460.0 STU:501 Type1 Inactive DFGin 5.6327 14.406 None -136.0, 173.79 77.97, 80.6 -165.88, 999.0 67.94, 103.04 999.0, 999.0 in-in in 9.4018 Saltbr-in 2.9242 HRD-in -69.54, -47.75 75.57, 5.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -138.84, -18.64 APE9-dihe-na -63.49, 153.65 APE8-dihe-in -64.27, 92.38 APE8-rot-in 304.32 APE67-dihe-in -63.41, -26.11 -54.68, -17.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.3588 D311N None None XRAY 2.8 0.185 0.24 B 312.0 270.0 23 30 18 12 [[183, 456]] 1.0 4u9a Homo sapiens TKL_IRAK4_HUMAN TKL 3e-83 285.4 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6EG9A Q9NWZ3 164 459 460.0 0LI:501 Type2 Inactive DFGout 14.0712 10.7156 None -127.45, 167.3 -138.69, 101.47 -85.85, 140.23 309.7, 100.41 -43.19, 999.0 in-out in 9.0273 Saltbr-out 6.6465 HRD-in -71.51, -48.43 70.86, -5.67 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 6.91 APE9-dihe-na 158.59, -165.8 APE8-dihe-in -114.99, 116.82 APE8-rot-in 299.55 APE67-dihe-in -67.65, -20.43 -63.19, -29.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.972 None None None XRAY 2.414 0.224 0.249 A 312.0 276.0 20 30 13 17 [[183, 456]] 1.0 6eg9 Homo sapiens TKL_IRAK4_HUMAN TKL 4.6e-84 288.0 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6EG9B Q9NWZ3 165 459 460.0 0LI:501 Type2 Inactive DFGout 14.2443 9.3953 None -135.81, 174.82 -152.29, 126.78 -163.75, 999.0 33.58, 60.29 999.0, 999.0 in-in in 8.9787 Saltbr-in 3.0904 HRD-in -69.81, -51.27 77.39, -7.02 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 146.5 APE9-dihe-na 95.5, 175.38 APE8-dihe-in -117.78, 118.94 APE8-rot-in 307.93 APE67-dihe-in -67.02, -18.64 -61.22, -30.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.6297 None None None XRAY 2.414 0.224 0.249 B 312.0 274.0 21 30 12 18 [[183, 456]] 1.0 6eg9 Homo sapiens TKL_IRAK4_HUMAN TKL 4.6e-84 288.0 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6EGAA Q9NWZ3 166 459 460.0 J8A:501 Type2 Inactive DFGout 14.8372 9.221 None -132.87, 171.64 -143.22, 111.2 -89.3, 999.0 283.17, 56.87 999.0, 999.0 in-in in 8.4692 Saltbr-in 2.523 HRD-in -60.76, -42.87 73.04, -12.28 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnni APE10-dihe-na 999.0, -143.73 APE9-dihe-na -70.15, -161.11 APE8-dihe-out -111.74, -12.32 APE8-rot-in 304.14 APE67-dihe-out -73.29, -17.17 93.23, -43.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.6219 None None None XRAY 2.512 0.232 0.267 A 312.0 266.0 28 30 12 18 [[183, 456]] 1.0 6ega Homo sapiens TKL_IRAK4_HUMAN TKL 4.6e-84 288.0 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6EGAB Q9NWZ3 164 459 460.0 J8A:501 Type2 Inactive DFGout 14.7494 10.183 None -139.75, 175.22 -156.01, 106.42 -83.08, 999.0 308.29, 92.5 999.0, 999.0 in-in in 8.7604 Saltbr-in 3.3724 HRD-in -65.42, -48.57 72.61, -7.89 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, -76.21 APE9-dihe-na 148.93, -171.19 APE8-dihe-in -115.49, 130.35 APE8-rot-in 312.15 APE67-dihe-in -70.04, -13.16 -55.8, -40.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.7443 None None None XRAY 2.512 0.232 0.267 B 312.0 269.0 27 30 12 18 [[183, 456]] 1.0 6ega Homo sapiens TKL_IRAK4_HUMAN TKL 4.6e-84 288.0 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5KX7A Q9NWZ3 192 459 460.0 No_ligand No_ligand Inactive None 7.5134 999.0 None -138.26, 174.6 58.57, 81.01 -106.91, 34.11 322.12, 87.89 -72.06, -44.46 none-none none 999.0 Saltbr-none 999.0 HRD-in -69.47, -47.61 72.64, 1.38 none-in-in SNCnii in-in ActLoopNT-in 2.7601 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.3, 154.34 APE9-dihe-na 136.56, -175.85 APE8-dihe-in -106.22, 109.07 APE8-rot-in 305.46 APE67-dihe-in -59.17, -17.42 -32.79, -54.17 APE12-dist-in 9.9579 APE11-dist-in 11.4997 APE10-dist-in 6.1778 APE9-dist-in 3.7121 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.8 0.213 0.25 A 301.0 240.0 45 30 26 4 [[183, 456]] 1.0 5kx7 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8TVND Q9NWZ3 165 459 460.0 VE9:501 Type1 Inactive None 999.0 999.0 None -128.0, 174.48 59.07, 74.82 -91.46, 22.14 999.0, 999.0 -68.15, -32.2 in-in in 8.7182 Saltbr-in 3.5248 HRD-in -66.97, -47.07 77.91, -9.26 in-in-in SNCiii in-in ActLoopNT-in 2.7388 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.76, 163.35 APE9-dihe-na 134.11, -178.04 APE8-dihe-in -111.72, 122.92 APE8-rot-in 303.39 APE67-dihe-in -72.86, -10.54 -60.52, -36.73 APE12-dist-in 9.9407 APE11-dist-in 11.4617 APE10-dist-in 5.9919 APE9-dist-in 3.5874 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 1.95 0.208 0.242 D 307.0 286.0 9 30 24 6 [[183, 456]] 1.0 8tvn Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 2OICC Q9NWZ3 161 458 460.0 STU:3 Type1 None DFGin 7.6419 14.5124 BLAminus -134.38, -175.33 55.45, 88.83 -103.9, 2.57 299.42, 100.27 -42.77, 999.0 in-in in 9.1756 Saltbr-in 3.2966 HRD-in -70.98, -49.49 84.28, -16.44 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na -109.35, 145.04 APE9-dihe-na 142.04, -179.34 APE8-dihe-in -123.52, 118.39 APE8-rot-in 307.07 APE67-dihe-in -69.67, -21.31 -65.38, -24.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.5672 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 C 301.0 280.0 18 30 20 10 [[183, 456]] 1.0 2oic Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5K72B Q9NWZ3 165 458 460.0 6QY:504 Type1 None DFGin 6.9184 14.7968 BLAminus -126.83, 172.54 63.1, 86.46 -103.47, 19.92 308.93, 101.56 -64.92, -35.48 in-in in 8.8719 Saltbr-in 3.0871 HRD-in -67.63, -51.12 79.83, -9.89 in-in-none SNCiin in-none ActLoopNT-in 2.8692 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 146.4 APE9-dihe-na 138.09, -173.14 APE8-dihe-in -106.76, 111.81 APE8-rot-in 311.41 APE67-dihe-in -65.66, -17.88 -41.88, -47.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.4064 APE9-dist-in 4.0839 None TPO345,SEP346 TPO345,SEP346 XRAY 2.22 0.215 0.225 B 301.0 267.0 27 30 16 14 [[183, 456]] 1.0 5k72 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5K7GB Q9NWZ3 165 458 460.0 6R0:503 Type1 None DFGin 6.9828 14.5764 BLAminus -125.44, 169.29 65.46, 85.11 -103.67, 20.54 309.11, 102.13 -65.88, -35.43 in-in in 8.8953 Saltbr-in 3.1333 HRD-in -66.71, -50.75 79.24, -11.2 in-in-none SNCiin in-none ActLoopNT-in 2.8554 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 145.13 APE9-dihe-na 139.01, -174.96 APE8-dihe-in -106.13, 110.24 APE8-rot-in 312.27 APE67-dihe-in -64.1, -19.47 -39.24, -50.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.428 APE9-dist-in 4.132 None TPO345,SEP346 TPO345,SEP346 XRAY 2.23 0.207 0.227 B 301.0 275.0 19 30 16 14 [[183, 456]] 1.0 5k7g Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 5W84B Q9NWZ3 168 459 460.0 9YY:4000 Type1 None DFGin 6.9172 14.7775 BLAminus -117.28, -176.87 50.45, 80.34 -103.74, 13.5 304.16, 91.69 -70.56, -13.43 in-none in 8.5423 Saltbr-none 999.0 HRD-in -59.01, -48.84 73.66, 4.88 none-in-in SNCnii in-in ActLoopNT-in 2.7863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.28, 157.08 APE9-dihe-na 134.47, -164.72 APE8-dihe-in -110.39, 105.06 APE8-rot-in 309.52 APE67-dihe-in -62.58, -18.58 -39.91, -49.41 APE12-dist-in 9.8472 APE11-dist-in 12.1046 APE10-dist-in 6.8178 APE9-dist-in 3.6538 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.9 0.202 0.248 B 305.0 264.0 28 30 25 5 [[183, 456]] 1.0 5w84 Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6LXYB Q9NWZ3 163 459 460.0 EXF:502 Type1 None DFGin 6.9731 14.1366 BLAminus -129.45, 177.84 61.74, 86.54 -106.07, 12.43 306.08, 97.48 -57.61, -29.04 in-none in 9.0982 Saltbr-none 999.0 HRD-in -68.65, -53.21 75.68, 1.0 none-in-in SNCnii in-in ActLoopNT-in 2.8068 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.47, 149.33 APE9-dihe-na 135.3, -175.41 APE8-dihe-in -105.49, 112.4 APE8-rot-in 312.11 APE67-dihe-in -59.55, -21.17 -51.5, -42.55 APE12-dist-in 10.1894 APE11-dist-in 11.6864 APE10-dist-in 6.444 APE9-dist-in 4.3325 None TPO345,SEP346 TPO345,SEP346 XRAY 2.19 0.202 0.231 B 305.0 297.0 0 30 30 0 [[183, 456]] 1.0 6lxy Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 8TVMC Q9NWZ3 160 458 460.0 VDC:501 Type1 None DFGin 6.907 14.6736 BLAminus -124.23, 176.14 60.41, 68.85 -88.16, 21.88 308.01, 97.71 -66.33, -43.48 in-none in 8.8732 Saltbr-none 999.0 HRD-in -71.38, -49.64 77.01, -7.35 none-in-in SNCnii in-in ActLoopNT-in 2.6838 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.63, 156.99 APE9-dihe-na 140.7, -171.01 APE8-dihe-in -113.25, 123.93 APE8-rot-in 312.17 APE67-dihe-in -64.66, -21.4 -62.46, -37.14 APE12-dist-in 9.7991 APE11-dist-in 11.1869 APE10-dist-in 6.2459 APE9-dist-in 3.9943 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.223 0.246 C 307.0 281.0 18 30 24 6 [[183, 456]] 1.0 8tvm Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6EGDA Q9NWZ3 165 458 460.0 J87:60501 Type1 None DFGin 6.8485 14.1837 BLAminus -141.24, -173.92 62.73, 75.05 -96.24, 8.11 294.89, 87.75 -42.03, -35.64 in-in in 8.8336 Saltbr-in 3.375 HRD-in -75.12, -50.55 72.64, 0.08 in-in-none SNCiin in-none ActLoopNT-in 2.6778 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -63.37, -20.6 999.0, -46.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.184 0.23 A 302.0 268.0 26 30 14 16 [[183, 456]] 1.0 6egd Homo sapiens TKL_IRAK4_HUMAN TKL 2.6e-83 285.5 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 6EGED Q9NWZ3 164 457 460.0 DL1:60501 Type1 None DFGin 6.4849 13.7691 BLAminus -131.26, -173.55 62.72, 71.71 -99.41, 12.5 304.64, 98.46 -67.05, -20.52 in-in in 8.9822 Saltbr-in 2.9789 HRD-in -74.07, -47.83 71.86, 0.89 in-in-none SNCiin in-none ActLoopNT-in 2.6901 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -66.83, -16.12 999.0, -13.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.401 0.179 0.201 D 302.0 282.0 12 30 25 5 [[183, 456]] 1.0 6ege Homo sapiens TKL_IRAK4_HUMAN TKL 2.6e-83 285.5 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4U97A Q9NWZ3 166 458 460.0 STU:501 Type1 None DFGin 7.218 14.4948 BLAminus -133.4, -177.52 44.45, 65.76 -75.86, 30.58 295.34, 78.33 -61.24, -17.68 in-in in 9.1113 Saltbr-in 2.7963 HRD-in -81.28, -51.43 74.22, 0.69 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.32, 150.98 APE9-dihe-na 154.49, -177.45 APE8-dihe-in -96.07, 115.4 APE8-rot-in 303.66 APE67-dihe-in -67.54, -17.85 -61.65, -28.02 APE12-dist-in 9.909 APE11-dist-in 11.8395 APE10-dist-in 7.0324 APE9-dist-in 3.8244 D311N None None XRAY 2.65 0.206 0.251 A 312.0 272.0 21 30 22 8 [[183, 456]] 1.0 4u97 Homo sapiens TKL_IRAK4_HUMAN TKL 3e-83 285.4 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
IRAK4 IRAK4_HUMAN 4U9AA Q9NWZ3 166 458 460.0 STU:501 Type1 None DFGin 7.0448 14.9069 BLAminus -101.08, -157.39 29.3, 88.18 -95.05, 25.51 282.71, 82.79 -64.14, 4.87 in-in in 8.9978 Saltbr-in 3.2256 HRD-in -68.43, -44.05 62.5, 13.64 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.36, 146.03 APE9-dihe-na 162.68, -156.1 APE8-dihe-in -121.4, 112.37 APE8-rot-in 316.45 APE67-dihe-in -59.48, -18.83 -58.3, -38.15 APE12-dist-in 9.9834 APE11-dist-in 11.9507 APE10-dist-in 7.2186 APE9-dist-in 3.878 D311N None None XRAY 2.8 0.185 0.24 A 312.0 272.0 21 30 22 8 [[183, 456]] 1.0 4u9a Homo sapiens TKL_IRAK4_HUMAN TKL 3e-83 285.4 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4

TKL_IRAK4 (Interleukin-1 receptor-associated kinase 4)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name