PDB: 6N8G — TKL IRAK4_HUMAN

Total number of chains: 4
Active chains: 3
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6N8GC

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TKL IRAK4 IRAK4_HUMAN 6N8GA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KFD Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6N8GB 2.0 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii KFD Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6N8GC 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KFD Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6N8GD 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KFD Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4

PDB: 6N8G — TKL IRAK4_HUMAN

Total number of chains: 4
Active chains: 3
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6N8GC

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TKL IRAK4 IRAK4_HUMAN 6N8GA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KFD Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 6N8GB 2.0 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii KFD Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 6N8GC 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KFD Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 6N8GD 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KFD Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens

PDB: 6N8G — TKL IRAK4_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism